-- dump date 20140619_234301 -- class Genbank::misc_feature -- table misc_feature_note -- id note 756272000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 756272000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272000003 Walker A motif; other site 756272000004 ATP binding site [chemical binding]; other site 756272000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 756272000006 DnaA box-binding interface [nucleotide binding]; other site 756272000007 xylose isomerase; Provisional; Region: PRK05474 756272000008 xylose isomerase; Region: xylose_isom_A; TIGR02630 756272000009 PhoD-like phosphatase; Region: PhoD; pfam09423 756272000010 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 756272000011 putative active site [active] 756272000012 putative metal binding site [ion binding]; other site 756272000013 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 756272000014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 756272000015 active site 756272000016 motif I; other site 756272000017 motif II; other site 756272000018 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 756272000019 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 756272000020 putative ADP-binding pocket [chemical binding]; other site 756272000021 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 756272000022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 756272000023 active site 756272000024 motif I; other site 756272000025 motif II; other site 756272000026 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 756272000027 trehalose synthase; Region: treS_nterm; TIGR02456 756272000028 active site 756272000029 catalytic site [active] 756272000030 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 756272000031 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 756272000032 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 756272000033 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 756272000034 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 756272000035 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 756272000036 lipoyl attachment site [posttranslational modification]; other site 756272000037 pyrroline-5-carboxylate reductase; Region: PLN02688 756272000038 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 756272000039 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 756272000040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272000041 ATP binding site [chemical binding]; other site 756272000042 putative Mg++ binding site [ion binding]; other site 756272000043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272000044 nucleotide binding region [chemical binding]; other site 756272000045 ATP-binding site [chemical binding]; other site 756272000046 Helicase associated domain (HA2); Region: HA2; pfam04408 756272000047 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 756272000048 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 756272000049 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 756272000050 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 756272000051 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 756272000052 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 756272000053 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 756272000054 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 756272000055 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 756272000056 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 756272000057 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 756272000058 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 756272000059 6-phosphogluconate dehydratase; Region: edd; TIGR01196 756272000060 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 756272000061 active site 756272000062 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 756272000063 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 756272000064 NAD(P) binding site [chemical binding]; other site 756272000065 catalytic residues [active] 756272000066 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 756272000067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 756272000068 ABC-ATPase subunit interface; other site 756272000069 dimer interface [polypeptide binding]; other site 756272000070 putative PBP binding regions; other site 756272000071 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 756272000072 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 756272000073 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 756272000074 active site 756272000075 hydrophilic channel; other site 756272000076 dimerization interface [polypeptide binding]; other site 756272000077 catalytic residues [active] 756272000078 active site lid [active] 756272000079 Ribonuclease P; Region: Ribonuclease_P; pfam00825 756272000080 Haemolytic domain; Region: Haemolytic; pfam01809 756272000081 hypothetical protein; Reviewed; Region: PRK09588 756272000082 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 756272000083 Transposase IS200 like; Region: Y1_Tnp; cl00848 756272000084 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 756272000085 active site 756272000086 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 756272000087 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 756272000088 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 756272000089 tRNA; other site 756272000090 putative tRNA binding site [nucleotide binding]; other site 756272000091 putative NADP binding site [chemical binding]; other site 756272000092 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 756272000093 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 756272000094 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 756272000095 active site 756272000096 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 756272000097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272000098 motif II; other site 756272000099 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 756272000100 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 756272000101 putative RNA binding site [nucleotide binding]; other site 756272000102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272000103 S-adenosylmethionine binding site [chemical binding]; other site 756272000104 Predicted amidohydrolase [General function prediction only]; Region: COG0388 756272000105 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 756272000106 active site 756272000107 catalytic triad [active] 756272000108 dimer interface [polypeptide binding]; other site 756272000109 SpoVR like protein; Region: SpoVR; pfam04293 756272000110 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 756272000111 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 756272000112 putative active site [active] 756272000113 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272000114 metal ion-dependent adhesion site (MIDAS); other site 756272000115 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 756272000116 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 756272000117 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 756272000118 active site 756272000119 dimer interface [polypeptide binding]; other site 756272000120 metal binding site [ion binding]; metal-binding site 756272000121 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272000122 Leucine-rich repeats; other site 756272000123 Substrate binding site [chemical binding]; other site 756272000124 Leucine rich repeat; Region: LRR_8; pfam13855 756272000125 Leucine rich repeat; Region: LRR_8; pfam13855 756272000126 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 756272000127 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272000128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272000129 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272000130 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272000131 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 756272000132 amidase catalytic site [active] 756272000133 Zn binding residues [ion binding]; other site 756272000134 substrate binding site [chemical binding]; other site 756272000135 AAA-like domain; Region: AAA_10; pfam12846 756272000136 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 756272000137 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 756272000138 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 756272000139 nudix motif; other site 756272000140 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 756272000141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272000142 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 756272000143 Sulfate transporter family; Region: Sulfate_transp; pfam00916 756272000144 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 756272000145 Sulfate transporter family; Region: Sulfate_transp; pfam00916 756272000146 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 756272000147 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 756272000148 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 756272000149 purine nucleoside phosphorylase; Provisional; Region: PRK08202 756272000150 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 756272000151 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 756272000152 active site 756272000153 DNA binding site [nucleotide binding] 756272000154 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 756272000155 Active_site [active] 756272000156 FMN-binding domain; Region: FMN_bind; pfam04205 756272000157 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 756272000158 Uncharacterized conserved protein [Function unknown]; Region: COG5361 756272000159 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 756272000160 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 756272000161 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 756272000162 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000163 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000164 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272000165 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272000166 DNA binding residues [nucleotide binding] 756272000167 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 756272000168 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 756272000169 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000170 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000171 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 756272000172 Strictosidine synthase; Region: Str_synth; pfam03088 756272000173 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272000174 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 756272000175 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272000176 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272000177 Metal-binding active site; metal-binding site 756272000178 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272000179 Sulfatase; Region: Sulfatase; pfam00884 756272000180 Sulfatase; Region: Sulfatase; cl17466 756272000181 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 756272000182 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 756272000183 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 756272000184 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 756272000185 putative active site [active] 756272000186 Zn binding site [ion binding]; other site 756272000187 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 756272000188 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 756272000189 metal binding site [ion binding]; metal-binding site 756272000190 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272000191 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 756272000192 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 756272000193 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 756272000194 NADP binding site [chemical binding]; other site 756272000195 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 756272000196 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 756272000197 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 756272000198 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 756272000199 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 756272000200 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 756272000201 Surface antigen; Region: Bac_surface_Ag; pfam01103 756272000202 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 756272000203 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 756272000204 dimerization interface [polypeptide binding]; other site 756272000205 active site 756272000206 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 756272000207 Cysteine-rich domain; Region: CCG; pfam02754 756272000208 Cysteine-rich domain; Region: CCG; pfam02754 756272000209 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 756272000210 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 756272000211 CAP-like domain; other site 756272000212 active site 756272000213 primary dimer interface [polypeptide binding]; other site 756272000214 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272000215 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 756272000216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272000217 ATP binding site [chemical binding]; other site 756272000218 Mg2+ binding site [ion binding]; other site 756272000219 G-X-G motif; other site 756272000220 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 756272000221 anchoring element; other site 756272000222 dimer interface [polypeptide binding]; other site 756272000223 ATP binding site [chemical binding]; other site 756272000224 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 756272000225 active site 756272000226 metal binding site [ion binding]; metal-binding site 756272000227 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 756272000228 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 756272000229 trimer interface [polypeptide binding]; other site 756272000230 active site 756272000231 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272000232 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272000233 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272000234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272000235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272000236 protein binding site [polypeptide binding]; other site 756272000237 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 756272000238 Ca2+ binding site [ion binding]; other site 756272000239 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 756272000240 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272000241 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272000242 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272000243 Cytochrome c; Region: Cytochrom_C; pfam00034 756272000244 Cytochrome c; Region: Cytochrom_C; pfam00034 756272000245 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 756272000246 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272000247 anti sigma factor interaction site; other site 756272000248 regulatory phosphorylation site [posttranslational modification]; other site 756272000249 Type II/IV secretion system protein; Region: T2SE; pfam00437 756272000250 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272000251 Walker A motif; other site 756272000252 ATP binding site [chemical binding]; other site 756272000253 Walker B motif; other site 756272000254 cell division protein MraZ; Reviewed; Region: PRK00326 756272000255 MraZ protein; Region: MraZ; pfam02381 756272000256 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 756272000257 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 756272000258 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 756272000259 Cation transport protein; Region: TrkH; cl17365 756272000260 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 756272000261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 756272000262 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 756272000263 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 756272000264 hypothetical protein; Provisional; Region: PRK13665 756272000265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272000266 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272000267 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272000268 Trp docking motif [polypeptide binding]; other site 756272000269 PQQ-like domain; Region: PQQ_2; pfam13360 756272000270 active site 756272000271 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 756272000272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272000273 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 756272000274 active site 756272000275 metal binding site [ion binding]; metal-binding site 756272000276 Predicted permease [General function prediction only]; Region: COG2985 756272000277 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 756272000278 TrkA-C domain; Region: TrkA_C; pfam02080 756272000279 TrkA-C domain; Region: TrkA_C; pfam02080 756272000280 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 756272000281 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 756272000282 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 756272000283 oligomer interface; other site 756272000284 ligand binding site; other site 756272000285 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 756272000286 dimer interface [polypeptide binding]; other site 756272000287 N-terminal domain interface [polypeptide binding]; other site 756272000288 sulfate 1 binding site; other site 756272000289 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272000290 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272000291 phosphopeptide binding site; other site 756272000292 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 756272000293 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272000294 Walker A motif; other site 756272000295 ATP binding site [chemical binding]; other site 756272000296 Walker B motif; other site 756272000297 ECF sigma factor; Region: Sigma70_ECF; pfam07638 756272000298 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 756272000299 TM2 domain; Region: TM2; pfam05154 756272000300 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 756272000301 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 756272000302 Flagellar protein FliS; Region: FliS; cl00654 756272000303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 756272000304 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 756272000305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 756272000306 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 756272000307 TPR repeat; Region: TPR_11; pfam13414 756272000308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000309 binding surface 756272000310 TPR motif; other site 756272000311 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 756272000312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000313 binding surface 756272000314 TPR motif; other site 756272000315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272000316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272000317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272000318 S-adenosylmethionine binding site [chemical binding]; other site 756272000319 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272000320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000321 binding surface 756272000322 TPR motif; other site 756272000323 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 756272000324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000325 binding surface 756272000326 TPR motif; other site 756272000327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000328 binding surface 756272000329 TPR motif; other site 756272000330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000331 binding surface 756272000332 TPR motif; other site 756272000333 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 756272000334 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272000335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272000336 active site 756272000337 ATP binding site [chemical binding]; other site 756272000338 substrate binding site [chemical binding]; other site 756272000339 activation loop (A-loop); other site 756272000340 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 756272000341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272000342 active site 756272000343 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 756272000344 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272000345 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272000346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000347 active site 756272000348 phosphorylation site [posttranslational modification] 756272000349 intermolecular recognition site; other site 756272000350 dimerization interface [polypeptide binding]; other site 756272000351 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 756272000352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272000353 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272000354 DNA binding residues [nucleotide binding] 756272000355 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 756272000356 Fasciclin domain; Region: Fasciclin; pfam02469 756272000357 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 756272000358 DNA binding residues [nucleotide binding] 756272000359 B12 binding domain; Region: B12-binding_2; pfam02607 756272000360 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 756272000361 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 756272000362 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 756272000363 putative NAD(P) binding site [chemical binding]; other site 756272000364 putative active site [active] 756272000365 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 756272000366 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000367 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272000368 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272000369 DNA interaction; other site 756272000370 Metal-binding active site; metal-binding site 756272000371 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 756272000372 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 756272000373 active site 756272000374 catalytic triad [active] 756272000375 oxyanion hole [active] 756272000376 TPR repeat; Region: TPR_11; pfam13414 756272000377 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 756272000378 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 756272000379 protein binding site [polypeptide binding]; other site 756272000380 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 756272000381 Catalytic dyad [active] 756272000382 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 756272000383 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 756272000384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272000385 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 756272000386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272000387 DNA binding residues [nucleotide binding] 756272000388 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 756272000389 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 756272000390 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 756272000391 hypothetical protein; Reviewed; Region: PRK12497 756272000392 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 756272000393 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272000394 Cytochrome c; Region: Cytochrom_C; cl11414 756272000395 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272000396 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272000397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000399 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 756272000400 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 756272000401 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 756272000402 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272000403 Sulfatase; Region: Sulfatase; pfam00884 756272000404 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 756272000405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 756272000406 Divergent AAA domain; Region: AAA_4; pfam04326 756272000407 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 756272000408 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 756272000409 active site 756272000410 intersubunit interface [polypeptide binding]; other site 756272000411 zinc binding site [ion binding]; other site 756272000412 Na+ binding site [ion binding]; other site 756272000413 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272000414 Chlorite dismutase; Region: Chlor_dismutase; cl01280 756272000415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272000416 non-specific DNA binding site [nucleotide binding]; other site 756272000417 salt bridge; other site 756272000418 sequence-specific DNA binding site [nucleotide binding]; other site 756272000419 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 756272000420 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 756272000421 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 756272000422 Global regulator protein family; Region: CsrA; cl00670 756272000423 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 756272000424 AAA domain; Region: AAA_24; pfam13479 756272000425 Protein of unknown function (DUF669); Region: DUF669; pfam05037 756272000426 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 756272000427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272000428 ATP binding site [chemical binding]; other site 756272000429 putative Mg++ binding site [ion binding]; other site 756272000430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272000431 nucleotide binding region [chemical binding]; other site 756272000432 ATP-binding site [chemical binding]; other site 756272000433 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 756272000434 polymerase nucleotide-binding site; other site 756272000435 DNA-binding residues [nucleotide binding]; DNA binding site 756272000436 nucleotide binding site [chemical binding]; other site 756272000437 primase nucleotide-binding site [nucleotide binding]; other site 756272000438 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 756272000439 Homeodomain-like domain; Region: HTH_23; cl17451 756272000440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272000441 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 756272000442 Terminase-like family; Region: Terminase_6; pfam03237 756272000443 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 756272000444 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 756272000445 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 756272000446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 756272000447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272000448 salt bridge; other site 756272000449 non-specific DNA binding site [nucleotide binding]; other site 756272000450 sequence-specific DNA binding site [nucleotide binding]; other site 756272000451 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 756272000452 Ligand Binding Site [chemical binding]; other site 756272000453 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272000454 active site 756272000455 catalytic residues [active] 756272000456 DNA binding site [nucleotide binding] 756272000457 Int/Topo IB signature motif; other site 756272000458 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 756272000459 potential frameshift: common BLAST hit: gi|283780428|ref|YP_003371183.1| von Willebrand factor A 756272000460 von Willebrand factor type A domain; Region: VWA_2; pfam13519 756272000461 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 756272000462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272000463 ATP binding site [chemical binding]; other site 756272000464 putative Mg++ binding site [ion binding]; other site 756272000465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272000466 nucleotide binding region [chemical binding]; other site 756272000467 ATP-binding site [chemical binding]; other site 756272000468 DEAD/H associated; Region: DEAD_assoc; pfam08494 756272000469 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 756272000470 FtsZ protein binding site [polypeptide binding]; other site 756272000471 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 756272000472 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 756272000473 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 756272000474 Pectic acid lyase; Region: Pec_lyase; pfam09492 756272000475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272000476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272000477 putative substrate translocation pore; other site 756272000478 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000479 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000480 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 756272000481 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 756272000482 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 756272000483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 756272000484 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 756272000485 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 756272000486 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 756272000487 putative RNA binding site [nucleotide binding]; other site 756272000488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272000489 S-adenosylmethionine binding site [chemical binding]; other site 756272000490 Methyltransferase domain; Region: Methyltransf_25; pfam13649 756272000491 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000492 Predicted membrane protein [Function unknown]; Region: COG2860 756272000493 UPF0126 domain; Region: UPF0126; pfam03458 756272000494 UPF0126 domain; Region: UPF0126; pfam03458 756272000495 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 756272000496 ApbE family; Region: ApbE; pfam02424 756272000497 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272000498 Uncharacterized conserved protein [Function unknown]; Region: COG1262 756272000499 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 756272000500 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000502 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000503 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000504 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272000505 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 756272000506 TrkA-N domain; Region: TrkA_N; pfam02254 756272000507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272000508 Coenzyme A binding pocket [chemical binding]; other site 756272000509 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 756272000510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272000511 motif II; other site 756272000512 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 756272000513 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 756272000514 Ligand binding site; other site 756272000515 DXD motif; other site 756272000516 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 756272000517 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 756272000518 Conserved membrane protein YqhR; Region: YqhR; pfam11085 756272000519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272000520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272000521 dimer interface [polypeptide binding]; other site 756272000522 phosphorylation site [posttranslational modification] 756272000523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272000524 ATP binding site [chemical binding]; other site 756272000525 Mg2+ binding site [ion binding]; other site 756272000526 G-X-G motif; other site 756272000527 Response regulator receiver domain; Region: Response_reg; pfam00072 756272000528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000529 active site 756272000530 phosphorylation site [posttranslational modification] 756272000531 intermolecular recognition site; other site 756272000532 dimerization interface [polypeptide binding]; other site 756272000533 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272000534 Protein of unknown function (DUF229); Region: DUF229; pfam02995 756272000535 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272000536 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272000537 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272000538 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 756272000539 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 756272000540 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 756272000541 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 756272000542 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 756272000543 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 756272000544 MraW methylase family; Region: Methyltransf_5; cl17771 756272000545 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272000546 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272000547 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272000548 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272000549 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 756272000550 threonyl-tRNA synthetase; Region: thrS; TIGR00418 756272000551 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 756272000552 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272000553 motif 1; other site 756272000554 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 756272000555 active site 756272000556 motif 2; other site 756272000557 motif 3; other site 756272000558 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 756272000559 anticodon binding site; other site 756272000560 trigger factor; Region: tig; TIGR00115 756272000561 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 756272000562 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272000563 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 756272000564 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 756272000565 active site 756272000566 Int/Topo IB signature motif; other site 756272000567 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 756272000568 dimer interface [polypeptide binding]; other site 756272000569 Citrate synthase; Region: Citrate_synt; pfam00285 756272000570 active site 756272000571 citrylCoA binding site [chemical binding]; other site 756272000572 oxalacetate/citrate binding site [chemical binding]; other site 756272000573 coenzyme A binding site [chemical binding]; other site 756272000574 catalytic triad [active] 756272000575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 756272000576 EVE domain; Region: EVE; cl00728 756272000577 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 756272000578 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 756272000579 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 756272000580 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 756272000581 hexamer interface [polypeptide binding]; other site 756272000582 ligand binding site [chemical binding]; other site 756272000583 putative active site [active] 756272000584 NAD(P) binding site [chemical binding]; other site 756272000585 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 756272000586 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 756272000587 HflX GTPase family; Region: HflX; cd01878 756272000588 G1 box; other site 756272000589 GTP/Mg2+ binding site [chemical binding]; other site 756272000590 Switch I region; other site 756272000591 G2 box; other site 756272000592 G3 box; other site 756272000593 Switch II region; other site 756272000594 G4 box; other site 756272000595 G5 box; other site 756272000596 sulfite reductase subunit beta; Provisional; Region: PRK13504 756272000597 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 756272000598 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 756272000599 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272000600 anti sigma factor interaction site; other site 756272000601 regulatory phosphorylation site [posttranslational modification]; other site 756272000602 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272000603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000604 active site 756272000605 phosphorylation site [posttranslational modification] 756272000606 intermolecular recognition site; other site 756272000607 dimerization interface [polypeptide binding]; other site 756272000608 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 756272000609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 756272000610 PAS fold; Region: PAS_4; pfam08448 756272000611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272000612 putative active site [active] 756272000613 heme pocket [chemical binding]; other site 756272000614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272000615 dimer interface [polypeptide binding]; other site 756272000616 phosphorylation site [posttranslational modification] 756272000617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272000618 ATP binding site [chemical binding]; other site 756272000619 Mg2+ binding site [ion binding]; other site 756272000620 G-X-G motif; other site 756272000621 Response regulator receiver domain; Region: Response_reg; pfam00072 756272000622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000623 active site 756272000624 phosphorylation site [posttranslational modification] 756272000625 intermolecular recognition site; other site 756272000626 dimerization interface [polypeptide binding]; other site 756272000627 Response regulator receiver domain; Region: Response_reg; pfam00072 756272000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000629 active site 756272000630 phosphorylation site [posttranslational modification] 756272000631 intermolecular recognition site; other site 756272000632 dimerization interface [polypeptide binding]; other site 756272000633 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 756272000634 putative binding surface; other site 756272000635 active site 756272000636 cytochrome c-550; Provisional; Region: psbV; cl17239 756272000637 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272000638 dihydroorotase; Provisional; Region: PRK07575 756272000639 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 756272000640 active site 756272000641 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 756272000642 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 756272000643 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 756272000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272000645 putative substrate translocation pore; other site 756272000646 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000647 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272000648 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 756272000649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272000650 binding surface 756272000651 TPR motif; other site 756272000652 TPR repeat; Region: TPR_11; pfam13414 756272000653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272000654 binding surface 756272000655 TPR motif; other site 756272000656 TPR repeat; Region: TPR_11; pfam13414 756272000657 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 756272000658 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 756272000659 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 756272000660 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272000661 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 756272000662 putative active site [active] 756272000663 putative metal binding site [ion binding]; other site 756272000664 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 756272000665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272000666 S-adenosylmethionine binding site [chemical binding]; other site 756272000667 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 756272000668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272000669 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 756272000670 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 756272000671 active site 756272000672 intracellular protease, PfpI family; Region: PfpI; TIGR01382 756272000673 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 756272000674 conserved cys residue [active] 756272000675 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000676 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 756272000678 putative acyl-acceptor binding pocket; other site 756272000679 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 756272000680 homotrimer interaction site [polypeptide binding]; other site 756272000681 active site 756272000682 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 756272000683 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 756272000684 dimer interface [polypeptide binding]; other site 756272000685 PYR/PP interface [polypeptide binding]; other site 756272000686 TPP binding site [chemical binding]; other site 756272000687 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 756272000688 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 756272000689 TPP-binding site [chemical binding]; other site 756272000690 dimer interface [polypeptide binding]; other site 756272000691 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 756272000692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 756272000693 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 756272000694 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 756272000695 putative NAD(P) binding site [chemical binding]; other site 756272000696 catalytic Zn binding site [ion binding]; other site 756272000697 structural Zn binding site [ion binding]; other site 756272000698 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 756272000699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272000700 FeS/SAM binding site; other site 756272000701 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272000702 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272000703 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272000704 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 756272000705 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272000706 putative catalytic site [active] 756272000707 putative metal binding site [ion binding]; other site 756272000708 putative phosphate binding site [ion binding]; other site 756272000709 haloalkane dehalogenase; Provisional; Region: PRK03204 756272000710 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 756272000711 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 756272000712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272000713 catalytic residue [active] 756272000714 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 756272000715 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 756272000716 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 756272000717 active site 756272000718 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 756272000719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 756272000720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272000721 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000722 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 756272000723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272000724 active site 756272000725 HIGH motif; other site 756272000726 nucleotide binding site [chemical binding]; other site 756272000727 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272000728 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 756272000729 KMSKS motif; other site 756272000730 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 756272000731 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000732 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000733 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272000734 CAAX protease self-immunity; Region: Abi; pfam02517 756272000735 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272000736 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272000737 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 756272000738 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272000739 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272000740 Sulfatase; Region: Sulfatase; cl17466 756272000741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 756272000742 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 756272000743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272000744 dimer interface [polypeptide binding]; other site 756272000745 phosphorylation site [posttranslational modification] 756272000746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272000747 ATP binding site [chemical binding]; other site 756272000748 Mg2+ binding site [ion binding]; other site 756272000749 G-X-G motif; other site 756272000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000751 Response regulator receiver domain; Region: Response_reg; pfam00072 756272000752 active site 756272000753 phosphorylation site [posttranslational modification] 756272000754 intermolecular recognition site; other site 756272000755 dimerization interface [polypeptide binding]; other site 756272000756 Global regulator protein family; Region: CsrA; pfam02599 756272000757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272000758 Response regulator receiver domain; Region: Response_reg; pfam00072 756272000759 active site 756272000760 phosphorylation site [posttranslational modification] 756272000761 intermolecular recognition site; other site 756272000762 dimerization interface [polypeptide binding]; other site 756272000763 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 756272000764 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 756272000765 ATP binding site [chemical binding]; other site 756272000766 Mg++ binding site [ion binding]; other site 756272000767 motif III; other site 756272000768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272000769 nucleotide binding region [chemical binding]; other site 756272000770 ATP-binding site [chemical binding]; other site 756272000771 FtsH Extracellular; Region: FtsH_ext; pfam06480 756272000772 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 756272000773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272000774 Walker A motif; other site 756272000775 ATP binding site [chemical binding]; other site 756272000776 Walker B motif; other site 756272000777 arginine finger; other site 756272000778 Peptidase family M41; Region: Peptidase_M41; pfam01434 756272000779 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 756272000780 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 756272000781 Ligand binding site; other site 756272000782 Putative Catalytic site; other site 756272000783 DXD motif; other site 756272000784 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 756272000785 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 756272000786 GTP binding site; other site 756272000787 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 756272000788 active site 756272000789 8-oxo-dGMP binding site [chemical binding]; other site 756272000790 nudix motif; other site 756272000791 metal binding site [ion binding]; metal-binding site 756272000792 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 756272000793 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 756272000794 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 756272000795 active site 756272000796 dimer interface [polypeptide binding]; other site 756272000797 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 756272000798 Ligand Binding Site [chemical binding]; other site 756272000799 Molecular Tunnel; other site 756272000800 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 756272000801 active site residue [active] 756272000802 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272000803 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272000804 active site 756272000805 catalytic tetrad [active] 756272000806 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 756272000807 short chain dehydrogenase; Validated; Region: PRK08264 756272000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272000809 NAD(P) binding site [chemical binding]; other site 756272000810 active site 756272000811 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272000812 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 756272000813 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 756272000814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 756272000815 MarR family; Region: MarR_2; cl17246 756272000816 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272000817 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 756272000818 Outer membrane efflux protein; Region: OEP; pfam02321 756272000819 Outer membrane efflux protein; Region: OEP; pfam02321 756272000820 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 756272000821 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 756272000822 GIY-YIG motif/motif A; other site 756272000823 active site 756272000824 catalytic site [active] 756272000825 putative DNA binding site [nucleotide binding]; other site 756272000826 metal binding site [ion binding]; metal-binding site 756272000827 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 756272000828 Protein of unknown function (DUF3550/UPF0682); Region: DUF3550; pfam12070 756272000829 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 756272000830 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 756272000831 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 756272000832 Catalytic site [active] 756272000833 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 756272000834 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 756272000835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272000836 Zn2+ binding site [ion binding]; other site 756272000837 Mg2+ binding site [ion binding]; other site 756272000838 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 756272000839 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272000840 metal ion-dependent adhesion site (MIDAS); other site 756272000841 TadE-like protein; Region: TadE; pfam07811 756272000842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272000843 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272000844 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272000845 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272000846 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272000847 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272000848 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272000849 Predicted membrane protein [Function unknown]; Region: COG2259 756272000850 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 756272000851 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272000852 Uncharacterized conserved protein [Function unknown]; Region: COG3391 756272000853 NHL repeat; Region: NHL; pfam01436 756272000854 NHL repeat; Region: NHL; pfam01436 756272000855 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 756272000856 putative metal binding site [ion binding]; other site 756272000857 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 756272000858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272000859 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 756272000860 putative metal binding site [ion binding]; other site 756272000861 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 756272000862 tandem repeat interface [polypeptide binding]; other site 756272000863 oligomer interface [polypeptide binding]; other site 756272000864 active site residues [active] 756272000865 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 756272000866 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 756272000867 tandem repeat interface [polypeptide binding]; other site 756272000868 oligomer interface [polypeptide binding]; other site 756272000869 active site residues [active] 756272000870 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 756272000871 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 756272000872 dimerization interface [polypeptide binding]; other site 756272000873 ATP binding site [chemical binding]; other site 756272000874 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 756272000875 dimerization interface [polypeptide binding]; other site 756272000876 ATP binding site [chemical binding]; other site 756272000877 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 756272000878 Peptidase family M50; Region: Peptidase_M50; pfam02163 756272000879 active site 756272000880 putative substrate binding region [chemical binding]; other site 756272000881 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 756272000882 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 756272000883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272000884 catalytic residues [active] 756272000885 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 756272000886 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 756272000887 active site 756272000888 Zn binding site [ion binding]; other site 756272000889 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 756272000890 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 756272000891 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 756272000892 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 756272000893 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000894 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272000895 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272000896 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272000897 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272000898 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272000899 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272000900 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272000901 maltose O-acetyltransferase; Provisional; Region: PRK10092 756272000902 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 756272000903 active site 756272000904 substrate binding site [chemical binding]; other site 756272000905 trimer interface [polypeptide binding]; other site 756272000906 CoA binding site [chemical binding]; other site 756272000907 Sulfatase; Region: Sulfatase; cl17466 756272000908 Sulfatase; Region: Sulfatase; cl17466 756272000909 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272000910 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272000911 hypothetical protein; Provisional; Region: PRK02227 756272000912 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 756272000913 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 756272000914 G1 box; other site 756272000915 putative GEF interaction site [polypeptide binding]; other site 756272000916 GTP/Mg2+ binding site [chemical binding]; other site 756272000917 Switch I region; other site 756272000918 G2 box; other site 756272000919 G3 box; other site 756272000920 Switch II region; other site 756272000921 G4 box; other site 756272000922 G5 box; other site 756272000923 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 756272000924 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 756272000925 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 756272000926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272000927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272000928 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 756272000929 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 756272000930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 756272000931 E3 interaction surface; other site 756272000932 lipoyl attachment site [posttranslational modification]; other site 756272000933 e3 binding domain; Region: E3_binding; pfam02817 756272000934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 756272000935 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 756272000936 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272000937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272000938 Walker A/P-loop; other site 756272000939 ATP binding site [chemical binding]; other site 756272000940 Q-loop/lid; other site 756272000941 ABC transporter signature motif; other site 756272000942 Walker B; other site 756272000943 D-loop; other site 756272000944 H-loop/switch region; other site 756272000945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 756272000946 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 756272000947 substrate binding site [chemical binding]; other site 756272000948 oxyanion hole (OAH) forming residues; other site 756272000949 trimer interface [polypeptide binding]; other site 756272000950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272000951 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 756272000952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 756272000953 Coenzyme A binding pocket [chemical binding]; other site 756272000954 Predicted integral membrane protein [Function unknown]; Region: COG5616 756272000955 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 756272000956 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 756272000957 active site 756272000958 Int/Topo IB signature motif; other site 756272000959 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272000960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 756272000961 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 756272000962 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 756272000963 Walker A/P-loop; other site 756272000964 ATP binding site [chemical binding]; other site 756272000965 Q-loop/lid; other site 756272000966 ABC transporter signature motif; other site 756272000967 Walker B; other site 756272000968 D-loop; other site 756272000969 H-loop/switch region; other site 756272000970 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 756272000971 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 756272000972 phosphate binding site [ion binding]; other site 756272000973 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 756272000974 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 756272000975 catalytic site [active] 756272000976 putative active site [active] 756272000977 putative substrate binding site [chemical binding]; other site 756272000978 HRDC domain; Region: HRDC; pfam00570 756272000979 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 756272000980 arginine-tRNA ligase; Region: PLN02286 756272000981 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 756272000982 active site 756272000983 HIGH motif; other site 756272000984 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 756272000985 KMSK motif region; other site 756272000986 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 756272000987 tRNA binding surface [nucleotide binding]; other site 756272000988 anticodon binding site; other site 756272000989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 756272000990 active site 756272000991 dimerization interface [polypeptide binding]; other site 756272000992 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 756272000993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 756272000994 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272000995 putative catalytic site [active] 756272000996 putative metal binding site [ion binding]; other site 756272000997 putative phosphate binding site [ion binding]; other site 756272000998 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 756272000999 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 756272001000 Domain of unknown function (DUF966); Region: DUF966; pfam06136 756272001001 Oligomerisation domain; Region: Oligomerisation; pfam02410 756272001002 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 756272001003 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272001004 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 756272001005 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 756272001006 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272001007 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272001008 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 756272001009 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 756272001010 glutamine binding [chemical binding]; other site 756272001011 catalytic triad [active] 756272001012 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 756272001013 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 756272001014 Walker A/P-loop; other site 756272001015 ATP binding site [chemical binding]; other site 756272001016 Q-loop/lid; other site 756272001017 ABC transporter signature motif; other site 756272001018 Walker B; other site 756272001019 D-loop; other site 756272001020 H-loop/switch region; other site 756272001021 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 756272001022 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272001023 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 756272001024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272001025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272001026 active site 756272001027 ATP binding site [chemical binding]; other site 756272001028 substrate binding site [chemical binding]; other site 756272001029 activation loop (A-loop); other site 756272001030 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 756272001031 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 756272001032 domain interfaces; other site 756272001033 active site 756272001034 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 756272001035 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 756272001036 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 756272001037 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 756272001038 active site 756272001039 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 756272001040 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 756272001041 carboxyltransferase (CT) interaction site; other site 756272001042 biotinylation site [posttranslational modification]; other site 756272001043 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 756272001044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272001045 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 756272001046 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 756272001047 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 756272001048 phosphofructokinase; Region: PFK_mixed; TIGR02483 756272001049 active site 756272001050 ADP/pyrophosphate binding site [chemical binding]; other site 756272001051 dimerization interface [polypeptide binding]; other site 756272001052 allosteric effector site; other site 756272001053 fructose-1,6-bisphosphate binding site; other site 756272001054 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272001055 shikimate kinase; Reviewed; Region: aroK; PRK00131 756272001056 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 756272001057 ADP binding site [chemical binding]; other site 756272001058 magnesium binding site [ion binding]; other site 756272001059 putative shikimate binding site; other site 756272001060 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 756272001061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 756272001062 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 756272001063 active site 756272001064 2-isopropylmalate synthase; Validated; Region: PRK00915 756272001065 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 756272001066 active site 756272001067 catalytic residues [active] 756272001068 metal binding site [ion binding]; metal-binding site 756272001069 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 756272001070 Predicted transcriptional regulators [Transcription]; Region: COG1695 756272001071 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 756272001072 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 756272001073 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 756272001074 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 756272001075 Putative esterase; Region: Esterase; pfam00756 756272001076 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 756272001077 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 756272001078 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 756272001079 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 756272001080 NADP-binding site; other site 756272001081 homotetramer interface [polypeptide binding]; other site 756272001082 substrate binding site [chemical binding]; other site 756272001083 homodimer interface [polypeptide binding]; other site 756272001084 active site 756272001085 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 756272001086 ThiC family; Region: ThiC; pfam01964 756272001087 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 756272001088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272001089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 756272001090 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 756272001091 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 756272001092 G1 box; other site 756272001093 GTP/Mg2+ binding site [chemical binding]; other site 756272001094 Switch I region; other site 756272001095 G2 box; other site 756272001096 Switch II region; other site 756272001097 G3 box; other site 756272001098 G4 box; other site 756272001099 G5 box; other site 756272001100 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 756272001101 G1 box; other site 756272001102 GTP/Mg2+ binding site [chemical binding]; other site 756272001103 Switch I region; other site 756272001104 G2 box; other site 756272001105 G3 box; other site 756272001106 Switch II region; other site 756272001107 G4 box; other site 756272001108 G5 box; other site 756272001109 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 756272001110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272001111 catalytic residue [active] 756272001112 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 756272001113 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 756272001114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272001115 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 756272001116 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 756272001117 Ion transport protein; Region: Ion_trans; pfam00520 756272001118 Ion channel; Region: Ion_trans_2; pfam07885 756272001119 NMT1/THI5 like; Region: NMT1; pfam09084 756272001120 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 756272001121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272001122 Coenzyme A binding pocket [chemical binding]; other site 756272001123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272001124 anti sigma factor interaction site; other site 756272001125 regulatory phosphorylation site [posttranslational modification]; other site 756272001126 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272001127 PQQ-like domain; Region: PQQ_2; pfam13360 756272001128 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272001129 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272001130 Trp docking motif [polypeptide binding]; other site 756272001131 active site 756272001132 PQQ-like domain; Region: PQQ_2; pfam13360 756272001133 Response regulator receiver domain; Region: Response_reg; pfam00072 756272001134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272001135 active site 756272001136 phosphorylation site [posttranslational modification] 756272001137 intermolecular recognition site; other site 756272001138 dimerization interface [polypeptide binding]; other site 756272001139 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 756272001140 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 756272001141 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 756272001142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272001143 Zn2+ binding site [ion binding]; other site 756272001144 Mg2+ binding site [ion binding]; other site 756272001145 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 756272001146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272001147 active site 756272001148 motif I; other site 756272001149 motif II; other site 756272001150 glycogen synthase; Provisional; Region: glgA; PRK00654 756272001151 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 756272001152 ADP-binding pocket [chemical binding]; other site 756272001153 homodimer interface [polypeptide binding]; other site 756272001154 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 756272001155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272001156 ATP binding site [chemical binding]; other site 756272001157 putative Mg++ binding site [ion binding]; other site 756272001158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272001159 nucleotide binding region [chemical binding]; other site 756272001160 ATP-binding site [chemical binding]; other site 756272001161 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 756272001162 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 756272001163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 756272001164 acyl-activating enzyme (AAE) consensus motif; other site 756272001165 AMP binding site [chemical binding]; other site 756272001166 active site 756272001167 CoA binding site [chemical binding]; other site 756272001168 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 756272001169 ATP-NAD kinase; Region: NAD_kinase; pfam01513 756272001170 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 756272001171 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 756272001172 peptide chain release factor 1; Validated; Region: prfA; PRK00591 756272001173 PCRF domain; Region: PCRF; pfam03462 756272001174 RF-1 domain; Region: RF-1; pfam00472 756272001175 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 756272001176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272001177 S-adenosylmethionine binding site [chemical binding]; other site 756272001178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 756272001179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 756272001180 hinge; other site 756272001181 active site 756272001182 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 756272001183 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 756272001184 dimer interface [polypeptide binding]; other site 756272001185 anticodon binding site; other site 756272001186 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 756272001187 homodimer interface [polypeptide binding]; other site 756272001188 motif 1; other site 756272001189 active site 756272001190 motif 2; other site 756272001191 GAD domain; Region: GAD; pfam02938 756272001192 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272001193 active site 756272001194 motif 3; other site 756272001195 enoyl-CoA hydratase; Validated; Region: PRK08139 756272001196 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 756272001197 substrate binding site [chemical binding]; other site 756272001198 oxyanion hole (OAH) forming residues; other site 756272001199 trimer interface [polypeptide binding]; other site 756272001200 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 756272001201 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 756272001202 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272001203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272001204 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272001205 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 756272001206 Peptidase family M50; Region: Peptidase_M50; pfam02163 756272001207 active site 756272001208 putative substrate binding region [chemical binding]; other site 756272001209 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 756272001210 dihydropteroate synthase; Region: DHPS; TIGR01496 756272001211 substrate binding pocket [chemical binding]; other site 756272001212 dimer interface [polypeptide binding]; other site 756272001213 inhibitor binding site; inhibition site 756272001214 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272001215 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272001216 DNA interaction; other site 756272001217 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272001218 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272001219 EF-hand domain pair; Region: EF_hand_5; pfam13499 756272001220 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272001221 fructuronate transporter; Provisional; Region: PRK10034; cl15264 756272001222 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 756272001223 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 756272001224 active site 756272001225 substrate binding site [chemical binding]; other site 756272001226 metal binding site [ion binding]; metal-binding site 756272001227 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 756272001228 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 756272001229 NodB motif; other site 756272001230 putative active site [active] 756272001231 putative catalytic site [active] 756272001232 putative Zn binding site [ion binding]; other site 756272001233 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272001234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001235 NAD(P) binding site [chemical binding]; other site 756272001236 active site 756272001237 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272001238 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 756272001239 NAD binding site [chemical binding]; other site 756272001240 putative substrate binding site 2 [chemical binding]; other site 756272001241 putative substrate binding site 1 [chemical binding]; other site 756272001242 active site 756272001243 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272001244 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 756272001245 putative NAD(P) binding site [chemical binding]; other site 756272001246 active site 756272001247 putative substrate binding site [chemical binding]; other site 756272001248 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 756272001249 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 756272001250 substrate binding site; other site 756272001251 tetramer interface; other site 756272001252 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272001253 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272001254 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 756272001255 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 756272001256 ligand binding site [chemical binding]; other site 756272001257 NAD binding site [chemical binding]; other site 756272001258 dimerization interface [polypeptide binding]; other site 756272001259 catalytic site [active] 756272001260 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 756272001261 putative L-serine binding site [chemical binding]; other site 756272001262 BON domain; Region: BON; pfam04972 756272001263 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 756272001264 active site 756272001265 dimerization interface [polypeptide binding]; other site 756272001266 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272001267 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272001268 phosphopeptide binding site; other site 756272001269 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272001270 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272001271 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272001272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272001273 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272001274 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001275 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272001276 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001277 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001278 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272001279 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001280 Transposase IS200 like; Region: Y1_Tnp; cl00848 756272001281 hypothetical protein; Provisional; Region: PRK08201 756272001282 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 756272001283 metal binding site [ion binding]; metal-binding site 756272001284 putative dimer interface [polypeptide binding]; other site 756272001285 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 756272001286 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 756272001287 CAAX protease self-immunity; Region: Abi; pfam02517 756272001288 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 756272001289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272001290 Walker A/P-loop; other site 756272001291 ATP binding site [chemical binding]; other site 756272001292 Q-loop/lid; other site 756272001293 ABC transporter signature motif; other site 756272001294 Walker B; other site 756272001295 D-loop; other site 756272001296 H-loop/switch region; other site 756272001297 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272001298 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 756272001299 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 756272001300 TrkA-N domain; Region: TrkA_N; pfam02254 756272001301 TrkA-C domain; Region: TrkA_C; pfam02080 756272001302 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 756272001303 Cation transport protein; Region: TrkH; pfam02386 756272001304 hypothetical protein; Provisional; Region: PRK12378 756272001305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272001306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 756272001307 active site 756272001308 metal binding site [ion binding]; metal-binding site 756272001309 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 756272001310 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 756272001311 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 756272001312 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 756272001313 DEAD/DEAH box helicase; Region: DEAD; pfam00270 756272001314 ATP binding site [chemical binding]; other site 756272001315 putative Mg++ binding site [ion binding]; other site 756272001316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272001317 nucleotide binding region [chemical binding]; other site 756272001318 ATP-binding site [chemical binding]; other site 756272001319 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 756272001320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272001321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 756272001322 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 756272001323 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 756272001324 active site 756272001325 dimer interface [polypeptide binding]; other site 756272001326 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 756272001327 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 756272001328 active site 756272001329 FMN binding site [chemical binding]; other site 756272001330 substrate binding site [chemical binding]; other site 756272001331 3Fe-4S cluster binding site [ion binding]; other site 756272001332 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 756272001333 domain interface; other site 756272001334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 756272001335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 756272001336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 756272001337 dimerization interface [polypeptide binding]; other site 756272001338 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 756272001339 active site lid residues [active] 756272001340 substrate binding pocket [chemical binding]; other site 756272001341 catalytic residues [active] 756272001342 substrate-Mg2+ binding site; other site 756272001343 aspartate-rich region 1; other site 756272001344 aspartate-rich region 2; other site 756272001345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272001346 dimer interface [polypeptide binding]; other site 756272001347 phosphorylation site [posttranslational modification] 756272001348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272001349 ATP binding site [chemical binding]; other site 756272001350 G-X-G motif; other site 756272001351 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 756272001352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001353 TPR motif; other site 756272001354 binding surface 756272001355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001356 binding surface 756272001357 TPR motif; other site 756272001358 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 756272001359 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001360 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001361 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 756272001362 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 756272001363 catalytic triad [active] 756272001364 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 756272001365 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 756272001366 dimer interface [polypeptide binding]; other site 756272001367 substrate binding site [chemical binding]; other site 756272001368 metal binding sites [ion binding]; metal-binding site 756272001369 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 756272001370 Fatty acid desaturase; Region: FA_desaturase; pfam00487 756272001371 putative di-iron ligands [ion binding]; other site 756272001372 GTP-binding protein LepA; Provisional; Region: PRK05433 756272001373 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 756272001374 G1 box; other site 756272001375 putative GEF interaction site [polypeptide binding]; other site 756272001376 GTP/Mg2+ binding site [chemical binding]; other site 756272001377 Switch I region; other site 756272001378 G2 box; other site 756272001379 G3 box; other site 756272001380 Switch II region; other site 756272001381 G4 box; other site 756272001382 G5 box; other site 756272001383 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 756272001384 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 756272001385 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 756272001386 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 756272001387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 756272001388 minor groove reading motif; other site 756272001389 helix-hairpin-helix signature motif; other site 756272001390 substrate binding pocket [chemical binding]; other site 756272001391 active site 756272001392 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 756272001393 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 756272001394 DNA binding and oxoG recognition site [nucleotide binding] 756272001395 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 756272001396 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 756272001397 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 756272001398 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 756272001399 Rhomboid family; Region: Rhomboid; pfam01694 756272001400 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 756272001401 ParB-like nuclease domain; Region: ParB; smart00470 756272001402 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 756272001403 PB1 interaction surface [polypeptide binding]; other site 756272001404 PB1 interaction site [polypeptide binding]; other site 756272001405 PB1 interaction site [polypeptide binding]; other site 756272001406 PB1 interaction surface [polypeptide binding]; other site 756272001407 PB1 interaction surface [polypeptide binding]; other site 756272001408 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 756272001409 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 756272001410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272001411 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 756272001412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272001413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001414 NAD(P) binding site [chemical binding]; other site 756272001415 active site 756272001416 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 756272001417 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 756272001418 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 756272001419 Putative addiction module component; Region: Unstab_antitox; pfam09720 756272001420 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 756272001421 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272001422 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272001423 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272001424 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272001425 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272001426 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 756272001427 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 756272001428 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 756272001429 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 756272001430 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 756272001431 NADP binding site [chemical binding]; other site 756272001432 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 756272001433 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 756272001434 active site 756272001435 (T/H)XGH motif; other site 756272001436 enolase; Provisional; Region: eno; PRK00077 756272001437 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 756272001438 dimer interface [polypeptide binding]; other site 756272001439 metal binding site [ion binding]; metal-binding site 756272001440 substrate binding pocket [chemical binding]; other site 756272001441 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 756272001442 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 756272001443 substrate binding site [chemical binding]; other site 756272001444 glutamase interaction surface [polypeptide binding]; other site 756272001445 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001446 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 756272001447 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 756272001448 catalytic residue [active] 756272001449 putative FPP diphosphate binding site; other site 756272001450 putative FPP binding hydrophobic cleft; other site 756272001451 dimer interface [polypeptide binding]; other site 756272001452 putative IPP diphosphate binding site; other site 756272001453 Global regulator protein family; Region: CsrA; pfam02599 756272001454 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 756272001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272001456 putative substrate translocation pore; other site 756272001457 mechanosensitive channel MscS; Provisional; Region: PRK10334 756272001458 Conserved TM helix; Region: TM_helix; pfam05552 756272001459 Mechanosensitive ion channel; Region: MS_channel; pfam00924 756272001460 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 756272001461 L11 interface [polypeptide binding]; other site 756272001462 putative EF-Tu interaction site [polypeptide binding]; other site 756272001463 putative EF-G interaction site [polypeptide binding]; other site 756272001464 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 756272001465 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 756272001466 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272001467 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272001468 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 756272001469 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 756272001470 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 756272001471 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 756272001472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272001473 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 756272001474 active site 756272001475 metal binding site [ion binding]; metal-binding site 756272001476 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 756272001477 galactarate dehydratase; Region: galactar-dH20; TIGR03248 756272001478 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 756272001479 CHC2 zinc finger; Region: zf-CHC2; cl17510 756272001480 DNA primase; Validated; Region: dnaG; PRK05667 756272001481 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 756272001482 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 756272001483 active site 756272001484 metal binding site [ion binding]; metal-binding site 756272001485 interdomain interaction site; other site 756272001486 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 756272001487 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 756272001488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272001489 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 756272001490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272001491 DNA binding residues [nucleotide binding] 756272001492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272001493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272001494 S-adenosylmethionine binding site [chemical binding]; other site 756272001495 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272001496 Sulfatase; Region: Sulfatase; pfam00884 756272001497 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272001498 putative catalytic site [active] 756272001499 putative metal binding site [ion binding]; other site 756272001500 putative phosphate binding site [ion binding]; other site 756272001501 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272001502 GTPase RsgA; Reviewed; Region: PRK00098 756272001503 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 756272001504 RNA binding site [nucleotide binding]; other site 756272001505 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 756272001506 GTPase/Zn-binding domain interface [polypeptide binding]; other site 756272001507 GTP/Mg2+ binding site [chemical binding]; other site 756272001508 G4 box; other site 756272001509 G5 box; other site 756272001510 G1 box; other site 756272001511 Switch I region; other site 756272001512 G2 box; other site 756272001513 G3 box; other site 756272001514 Switch II region; other site 756272001515 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272001516 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272001517 phosphopeptide binding site; other site 756272001518 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272001519 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001520 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 756272001521 active site 756272001522 ribulose/triose binding site [chemical binding]; other site 756272001523 phosphate binding site [ion binding]; other site 756272001524 substrate (anthranilate) binding pocket [chemical binding]; other site 756272001525 product (indole) binding pocket [chemical binding]; other site 756272001526 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 756272001527 putative active site [active] 756272001528 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 756272001529 ferrochelatase; Reviewed; Region: hemH; PRK00035 756272001530 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 756272001531 C-terminal domain interface [polypeptide binding]; other site 756272001532 active site 756272001533 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 756272001534 active site 756272001535 N-terminal domain interface [polypeptide binding]; other site 756272001536 Fatty acid desaturase; Region: FA_desaturase; pfam00487 756272001537 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 756272001538 Di-iron ligands [ion binding]; other site 756272001539 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 756272001540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272001541 S-adenosylmethionine binding site [chemical binding]; other site 756272001542 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 756272001543 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 756272001544 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 756272001545 FMN binding site [chemical binding]; other site 756272001546 active site 756272001547 catalytic residues [active] 756272001548 substrate binding site [chemical binding]; other site 756272001549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 756272001550 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272001551 catalytic residues [active] 756272001552 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 756272001553 transcription termination factor Rho; Provisional; Region: PRK12608 756272001554 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 756272001555 RNA binding site [nucleotide binding]; other site 756272001556 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272001557 Walker A motif; other site 756272001558 ATP binding site [chemical binding]; other site 756272001559 Walker B motif; other site 756272001560 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 756272001561 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 756272001562 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 756272001563 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 756272001564 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 756272001565 S-adenosylmethionine synthetase; Validated; Region: PRK05250 756272001566 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 756272001567 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 756272001568 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 756272001569 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 756272001570 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 756272001571 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272001572 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 756272001573 dimer interface [polypeptide binding]; other site 756272001574 active site 756272001575 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272001576 Sulfatase; Region: Sulfatase; pfam00884 756272001577 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 756272001578 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272001579 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272001580 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272001581 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272001582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272001583 S-adenosylmethionine binding site [chemical binding]; other site 756272001584 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 756272001585 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 756272001586 N- and C-terminal domain interface [polypeptide binding]; other site 756272001587 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 756272001588 active site 756272001589 putative catalytic site [active] 756272001590 metal binding site [ion binding]; metal-binding site 756272001591 ATP binding site [chemical binding]; other site 756272001592 carbohydrate binding site [chemical binding]; other site 756272001593 FOG: CBS domain [General function prediction only]; Region: COG0517 756272001594 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 756272001595 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 756272001596 Fe-S cluster binding site [ion binding]; other site 756272001597 active site 756272001598 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 756272001599 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 756272001600 Protein export membrane protein; Region: SecD_SecF; cl14618 756272001601 Preprotein translocase subunit; Region: YajC; pfam02699 756272001602 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 756272001603 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 756272001604 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 756272001605 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 756272001606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272001607 FeS/SAM binding site; other site 756272001608 TRAM domain; Region: TRAM; cl01282 756272001609 elongation factor P; Validated; Region: PRK00529 756272001610 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 756272001611 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 756272001612 RNA binding site [nucleotide binding]; other site 756272001613 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 756272001614 RNA binding site [nucleotide binding]; other site 756272001615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272001616 Radical SAM superfamily; Region: Radical_SAM; pfam04055 756272001617 FeS/SAM binding site; other site 756272001618 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 756272001619 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272001620 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 756272001621 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272001622 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272001623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001624 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272001625 Pectic acid lyase; Region: Pec_lyase; pfam09492 756272001626 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 756272001627 Uncharacterized conserved protein [Function unknown]; Region: COG5361 756272001628 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 756272001629 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 756272001630 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 756272001631 Isochorismatase family; Region: Isochorismatase; pfam00857 756272001632 catalytic triad [active] 756272001633 conserved cis-peptide bond; other site 756272001634 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 756272001635 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 756272001636 minor groove reading motif; other site 756272001637 helix-hairpin-helix signature motif; other site 756272001638 substrate binding pocket [chemical binding]; other site 756272001639 active site 756272001640 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 756272001641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 756272001642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272001643 Coenzyme A binding pocket [chemical binding]; other site 756272001644 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 756272001645 hydrophobic ligand binding site; other site 756272001646 Phospholipid methyltransferase; Region: PEMT; pfam04191 756272001647 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 756272001648 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 756272001649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 756272001650 hydrophobic ligand binding site; other site 756272001651 putative hydrolase; Provisional; Region: PRK11460 756272001652 Predicted esterase [General function prediction only]; Region: COG0400 756272001653 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 756272001654 hydrophobic ligand binding site; other site 756272001655 Predicted transcriptional regulator [Transcription]; Region: COG2378 756272001656 HTH domain; Region: HTH_11; pfam08279 756272001657 WYL domain; Region: WYL; pfam13280 756272001658 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 756272001659 Penicillinase repressor; Region: Pencillinase_R; pfam03965 756272001660 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 756272001661 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272001662 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 756272001663 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 756272001664 putative active site [active] 756272001665 putative metal-binding site [ion binding]; other site 756272001666 Part of AAA domain; Region: AAA_19; pfam13245 756272001667 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 756272001668 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 756272001669 metal ion-dependent adhesion site (MIDAS); other site 756272001670 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272001671 structural tetrad; other site 756272001672 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272001673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272001674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272001675 active site 756272001676 ATP binding site [chemical binding]; other site 756272001677 substrate binding site [chemical binding]; other site 756272001678 activation loop (A-loop); other site 756272001679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001680 TPR motif; other site 756272001681 binding surface 756272001682 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 756272001683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001684 short chain dehydrogenase; Validated; Region: PRK08264 756272001685 NAD(P) binding site [chemical binding]; other site 756272001686 active site 756272001687 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272001688 Predicted transcriptional regulators [Transcription]; Region: COG1733 756272001689 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 756272001690 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272001691 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001692 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272001693 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272001694 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 756272001695 RNAase interaction site [polypeptide binding]; other site 756272001696 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 756272001697 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 756272001698 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 756272001699 active site 756272001700 Ecdysteroid kinase; Region: EcKinase; cl17738 756272001701 Phosphotransferase enzyme family; Region: APH; pfam01636 756272001702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 756272001703 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272001704 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001705 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272001706 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 756272001707 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 756272001708 putative NAD(P) binding site [chemical binding]; other site 756272001709 Isochorismatase family; Region: Isochorismatase; pfam00857 756272001710 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 756272001711 catalytic triad [active] 756272001712 dimer interface [polypeptide binding]; other site 756272001713 conserved cis-peptide bond; other site 756272001714 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 756272001715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272001716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272001717 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 756272001718 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 756272001719 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 756272001720 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 756272001721 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 756272001722 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272001723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001724 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272001725 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 756272001726 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 756272001727 short chain dehydrogenase; Provisional; Region: PRK12937 756272001728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001729 NAD(P) binding site [chemical binding]; other site 756272001730 active site 756272001731 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 756272001732 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 756272001733 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 756272001734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001735 binding surface 756272001736 TPR motif; other site 756272001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001738 binding surface 756272001739 TPR motif; other site 756272001740 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 756272001741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272001742 binding surface 756272001743 TPR motif; other site 756272001744 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 756272001745 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 756272001746 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 756272001747 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 756272001748 putative RNA binding site [nucleotide binding]; other site 756272001749 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 756272001750 homopentamer interface [polypeptide binding]; other site 756272001751 active site 756272001752 transcription termination factor Rho; Provisional; Region: rho; PRK09376 756272001753 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 756272001754 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 756272001755 RNA binding site [nucleotide binding]; other site 756272001756 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 756272001757 multimer interface [polypeptide binding]; other site 756272001758 Walker A motif; other site 756272001759 ATP binding site [chemical binding]; other site 756272001760 Walker B motif; other site 756272001761 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 756272001762 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 756272001763 CoA-binding site [chemical binding]; other site 756272001764 ATP-binding [chemical binding]; other site 756272001765 Phosphoglycerate kinase; Region: PGK; pfam00162 756272001766 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 756272001767 substrate binding site [chemical binding]; other site 756272001768 hinge regions; other site 756272001769 ADP binding site [chemical binding]; other site 756272001770 catalytic site [active] 756272001771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001772 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 756272001773 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272001774 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272001775 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272001776 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 756272001777 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 756272001778 Cl binding site [ion binding]; other site 756272001779 oligomer interface [polypeptide binding]; other site 756272001780 Uncharacterized conserved protein [Function unknown]; Region: COG5361 756272001781 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 756272001782 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 756272001783 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 756272001784 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 756272001785 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272001786 Zn2+ binding site [ion binding]; other site 756272001787 Mg2+ binding site [ion binding]; other site 756272001788 AAA domain; Region: AAA_33; pfam13671 756272001789 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 756272001790 RNA ligase; Region: RNA_ligase; pfam09414 756272001791 SEC-C motif; Region: SEC-C; pfam02810 756272001792 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 756272001793 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 756272001794 DNA methylase; Region: N6_N4_Mtase; pfam01555 756272001795 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 756272001796 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 756272001797 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 756272001798 catalytic center binding site [active] 756272001799 ATP binding site [chemical binding]; other site 756272001800 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 756272001801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272001802 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272001803 putative active site [active] 756272001804 heme pocket [chemical binding]; other site 756272001805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272001806 putative active site [active] 756272001807 heme pocket [chemical binding]; other site 756272001808 PAS fold; Region: PAS_4; pfam08448 756272001809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272001810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272001811 dimer interface [polypeptide binding]; other site 756272001812 phosphorylation site [posttranslational modification] 756272001813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272001814 ATP binding site [chemical binding]; other site 756272001815 Mg2+ binding site [ion binding]; other site 756272001816 G-X-G motif; other site 756272001817 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 756272001818 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 756272001819 TPP-binding site [chemical binding]; other site 756272001820 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 756272001821 dimer interface [polypeptide binding]; other site 756272001822 PYR/PP interface [polypeptide binding]; other site 756272001823 TPP binding site [chemical binding]; other site 756272001824 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 756272001825 putative substrate binding site [chemical binding]; other site 756272001826 putative ATP binding site [chemical binding]; other site 756272001827 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 756272001828 MG2 domain; Region: A2M_N; pfam01835 756272001829 Alpha-2-macroglobulin family; Region: A2M; pfam00207 756272001830 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 756272001831 surface patch; other site 756272001832 thioester region; other site 756272001833 specificity defining residues; other site 756272001834 AsmA family; Region: AsmA; pfam05170 756272001835 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 756272001836 active site 756272001837 catalytic site [active] 756272001838 substrate binding site [chemical binding]; other site 756272001839 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 756272001840 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272001841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272001842 Walker A motif; other site 756272001843 ATP binding site [chemical binding]; other site 756272001844 Walker B motif; other site 756272001845 arginine finger; other site 756272001846 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272001847 anti sigma factor interaction site; other site 756272001848 regulatory phosphorylation site [posttranslational modification]; other site 756272001849 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 756272001850 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 756272001851 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 756272001852 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 756272001853 Predicted membrane protein [Function unknown]; Region: COG4325 756272001854 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 756272001855 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 756272001856 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 756272001857 Predicted permease; Region: DUF318; cl17795 756272001858 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 756272001859 Part of AAA domain; Region: AAA_19; pfam13245 756272001860 AAA domain; Region: AAA_14; pfam13173 756272001861 Family description; Region: UvrD_C_2; pfam13538 756272001862 Tic20-like protein; Region: Tic20; pfam09685 756272001863 Short C-terminal domain; Region: SHOCT; pfam09851 756272001864 Tic20-like protein; Region: Tic20; pfam09685 756272001865 Tic20-like protein; Region: Tic20; pfam09685 756272001866 Protein of unknown function (DUF817); Region: DUF817; pfam05675 756272001867 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 756272001868 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 756272001869 putative active site [active] 756272001870 catalytic triad [active] 756272001871 putative dimer interface [polypeptide binding]; other site 756272001872 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 756272001873 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 756272001874 dimer interface [polypeptide binding]; other site 756272001875 putative functional site; other site 756272001876 putative MPT binding site; other site 756272001877 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 756272001878 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 756272001879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272001880 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 756272001881 Walker A/P-loop; other site 756272001882 ATP binding site [chemical binding]; other site 756272001883 Q-loop/lid; other site 756272001884 ABC transporter signature motif; other site 756272001885 Walker B; other site 756272001886 D-loop; other site 756272001887 H-loop/switch region; other site 756272001888 MASE1; Region: MASE1; cl17823 756272001889 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 756272001890 TrkA-N domain; Region: TrkA_N; pfam02254 756272001891 NAD-dependent deacetylase; Provisional; Region: PRK00481 756272001892 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 756272001893 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 756272001894 FMN binding site [chemical binding]; other site 756272001895 dimer interface [polypeptide binding]; other site 756272001896 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272001897 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272001898 Sulfatase; Region: Sulfatase; cl17466 756272001899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272001900 Coenzyme A binding pocket [chemical binding]; other site 756272001901 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 756272001902 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 756272001903 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 756272001904 Walker A/P-loop; other site 756272001905 ATP binding site [chemical binding]; other site 756272001906 Q-loop/lid; other site 756272001907 ABC transporter signature motif; other site 756272001908 Walker B; other site 756272001909 D-loop; other site 756272001910 H-loop/switch region; other site 756272001911 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 756272001912 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 756272001913 dimerization interface [polypeptide binding]; other site 756272001914 DPS ferroxidase diiron center [ion binding]; other site 756272001915 ion pore; other site 756272001916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 756272001917 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 756272001918 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 756272001919 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 756272001920 catalytic residues [active] 756272001921 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 756272001922 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 756272001923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272001924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272001925 DNA binding residues [nucleotide binding] 756272001926 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 756272001927 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272001928 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272001929 phosphopeptide binding site; other site 756272001930 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 756272001931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001932 NAD(P) binding site [chemical binding]; other site 756272001933 active site 756272001934 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272001935 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272001936 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 756272001937 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 756272001938 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 756272001939 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 756272001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272001941 ATP binding site [chemical binding]; other site 756272001942 putative Mg++ binding site [ion binding]; other site 756272001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272001944 nucleotide binding region [chemical binding]; other site 756272001945 ATP-binding site [chemical binding]; other site 756272001946 TRCF domain; Region: TRCF; pfam03461 756272001947 Transposase IS200 like; Region: Y1_Tnp; cl00848 756272001948 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272001949 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 756272001950 Substrate binding site; other site 756272001951 Mg++ binding site; other site 756272001952 Methane oxygenase PmoA; Region: PmoA; pfam14100 756272001953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272001954 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 756272001955 NAD(P) binding site [chemical binding]; other site 756272001956 active site 756272001957 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 756272001958 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 756272001959 heme-binding site [chemical binding]; other site 756272001960 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 756272001961 FAD binding pocket [chemical binding]; other site 756272001962 FAD binding motif [chemical binding]; other site 756272001963 phosphate binding motif [ion binding]; other site 756272001964 beta-alpha-beta structure motif; other site 756272001965 NAD binding pocket [chemical binding]; other site 756272001966 Heme binding pocket [chemical binding]; other site 756272001967 Rrf2 family protein; Region: rrf2_super; TIGR00738 756272001968 Transcriptional regulator; Region: Rrf2; pfam02082 756272001969 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272001970 Trp docking motif [polypeptide binding]; other site 756272001971 PQQ-like domain; Region: PQQ_2; pfam13360 756272001972 active site 756272001973 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272001974 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272001975 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272001976 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 756272001977 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 756272001978 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 756272001979 RNA binding site [nucleotide binding]; other site 756272001980 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 756272001981 RNA binding site [nucleotide binding]; other site 756272001982 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 756272001983 RNA binding site [nucleotide binding]; other site 756272001984 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 756272001985 RNA binding site [nucleotide binding]; other site 756272001986 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 756272001987 RNA binding site [nucleotide binding]; other site 756272001988 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 756272001989 RNA binding site [nucleotide binding]; other site 756272001990 domain interface; other site 756272001991 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 756272001992 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 756272001993 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 756272001994 acetyl-CoA synthetase; Provisional; Region: PRK00174 756272001995 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 756272001996 active site 756272001997 CoA binding site [chemical binding]; other site 756272001998 acyl-activating enzyme (AAE) consensus motif; other site 756272001999 AMP binding site [chemical binding]; other site 756272002000 acetate binding site [chemical binding]; other site 756272002001 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 756272002002 putative active site [active] 756272002003 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 756272002004 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 756272002005 Walker A motif; other site 756272002006 Fe-S metabolism associated domain; Region: SufE; cl00951 756272002007 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 756272002008 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 756272002009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272002010 catalytic residue [active] 756272002011 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272002012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272002013 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272002014 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272002015 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 756272002016 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 756272002017 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 756272002018 generic binding surface II; other site 756272002019 generic binding surface I; other site 756272002020 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 756272002021 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 756272002022 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 756272002023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272002024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272002025 homodimer interface [polypeptide binding]; other site 756272002026 catalytic residue [active] 756272002027 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 756272002028 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 756272002029 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 756272002030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272002031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272002032 DNA binding residues [nucleotide binding] 756272002033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002034 putative active site [active] 756272002035 PAS fold; Region: PAS_3; pfam08447 756272002036 heme pocket [chemical binding]; other site 756272002037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002038 PAS domain; Region: PAS_9; pfam13426 756272002039 putative active site [active] 756272002040 heme pocket [chemical binding]; other site 756272002041 PAS domain; Region: PAS; smart00091 756272002042 PAS domain; Region: PAS_9; pfam13426 756272002043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002044 PAS domain; Region: PAS_9; pfam13426 756272002045 putative active site [active] 756272002046 heme pocket [chemical binding]; other site 756272002047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272002048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272002049 dimer interface [polypeptide binding]; other site 756272002050 phosphorylation site [posttranslational modification] 756272002051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272002052 ATP binding site [chemical binding]; other site 756272002053 Mg2+ binding site [ion binding]; other site 756272002054 G-X-G motif; other site 756272002055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272002056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272002057 active site 756272002058 phosphorylation site [posttranslational modification] 756272002059 intermolecular recognition site; other site 756272002060 dimerization interface [polypeptide binding]; other site 756272002061 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 756272002062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272002063 FeS/SAM binding site; other site 756272002064 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 756272002065 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 756272002066 Uncharacterized conserved protein [Function unknown]; Region: COG3189 756272002067 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272002068 Methyltransferase domain; Region: Methyltransf_12; pfam08242 756272002069 S-adenosylmethionine binding site [chemical binding]; other site 756272002070 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 756272002071 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 756272002072 Walker A/P-loop; other site 756272002073 ATP binding site [chemical binding]; other site 756272002074 Q-loop/lid; other site 756272002075 ABC transporter signature motif; other site 756272002076 Walker B; other site 756272002077 D-loop; other site 756272002078 H-loop/switch region; other site 756272002079 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 756272002080 putative carbohydrate binding site [chemical binding]; other site 756272002081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002082 S-adenosylmethionine binding site [chemical binding]; other site 756272002083 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 756272002084 glutamine synthetase, type I; Region: GlnA; TIGR00653 756272002085 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 756272002086 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 756272002087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272002088 Coenzyme A binding pocket [chemical binding]; other site 756272002089 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 756272002090 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 756272002091 Protein of unknown function (DUF497); Region: DUF497; cl01108 756272002092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272002093 non-specific DNA binding site [nucleotide binding]; other site 756272002094 salt bridge; other site 756272002095 sequence-specific DNA binding site [nucleotide binding]; other site 756272002096 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272002097 Sulfatase; Region: Sulfatase; pfam00884 756272002098 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 756272002099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272002100 Coenzyme A binding pocket [chemical binding]; other site 756272002101 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272002102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272002103 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 756272002104 N- and C-terminal domain interface [polypeptide binding]; other site 756272002105 D-xylulose kinase; Region: XylB; TIGR01312 756272002106 active site 756272002107 MgATP binding site [chemical binding]; other site 756272002108 catalytic site [active] 756272002109 metal binding site [ion binding]; metal-binding site 756272002110 xylulose binding site [chemical binding]; other site 756272002111 homodimer interface [polypeptide binding]; other site 756272002112 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 756272002113 TPR repeat; Region: TPR_11; pfam13414 756272002114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002115 binding surface 756272002116 TPR motif; other site 756272002117 aminotransferase; Validated; Region: PRK08175 756272002118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272002119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272002120 homodimer interface [polypeptide binding]; other site 756272002121 catalytic residue [active] 756272002122 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002123 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 756272002124 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272002125 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272002126 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272002127 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 756272002128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 756272002129 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 756272002130 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272002131 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 756272002132 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272002133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272002134 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 756272002135 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 756272002136 iron-sulfur cluster [ion binding]; other site 756272002137 [2Fe-2S] cluster binding site [ion binding]; other site 756272002138 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 756272002139 nucleotide binding site [chemical binding]; other site 756272002140 substrate binding site [chemical binding]; other site 756272002141 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002142 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002143 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002144 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002145 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272002146 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272002147 active site 756272002148 metal binding site [ion binding]; metal-binding site 756272002149 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 756272002150 putative ligand binding site [chemical binding]; other site 756272002151 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002152 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 756272002153 Uncharacterized conserved protein [Function unknown]; Region: COG0432 756272002154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272002155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272002156 active site 756272002157 ATP binding site [chemical binding]; other site 756272002158 substrate binding site [chemical binding]; other site 756272002159 activation loop (A-loop); other site 756272002160 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272002161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272002162 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272002163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272002164 DNA binding residues [nucleotide binding] 756272002165 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272002166 Fungal symportin 1 (syo1) and similar proteins; Region: Syo1_like; cd13394 756272002167 SprT homologues; Region: SprT; cl01182 756272002168 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 756272002169 PGAP1-like protein; Region: PGAP1; pfam07819 756272002170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272002171 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 756272002172 Cytochrome P450; Region: p450; cl12078 756272002173 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 756272002174 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 756272002175 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 756272002176 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272002177 Protein export membrane protein; Region: SecD_SecF; cl14618 756272002178 Global regulator protein family; Region: CsrA; pfam02599 756272002179 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272002180 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 756272002181 E3 interaction surface; other site 756272002182 lipoyl attachment site [posttranslational modification]; other site 756272002183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 756272002184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 756272002185 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 756272002186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 756272002187 active site 756272002188 DNA binding site [nucleotide binding] 756272002189 Int/Topo IB signature motif; other site 756272002190 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 756272002191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272002192 Walker A motif; other site 756272002193 ATP binding site [chemical binding]; other site 756272002194 Walker B motif; other site 756272002195 arginine finger; other site 756272002196 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 756272002197 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 756272002198 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 756272002199 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272002200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002201 S-adenosylmethionine binding site [chemical binding]; other site 756272002202 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272002203 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 756272002204 active site 756272002205 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 756272002206 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 756272002207 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 756272002208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 756272002209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272002210 non-specific DNA binding site [nucleotide binding]; other site 756272002211 salt bridge; other site 756272002212 sequence-specific DNA binding site [nucleotide binding]; other site 756272002213 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 756272002214 HsdM N-terminal domain; Region: HsdM_N; pfam12161 756272002215 Methyltransferase domain; Region: Methyltransf_26; pfam13659 756272002216 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 756272002217 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 756272002218 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 756272002219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272002220 ATP binding site [chemical binding]; other site 756272002221 putative Mg++ binding site [ion binding]; other site 756272002222 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 756272002223 Protein of unknown function DUF45; Region: DUF45; pfam01863 756272002224 Uncharacterized conserved protein [Function unknown]; Region: COG1479 756272002225 Protein of unknown function DUF262; Region: DUF262; pfam03235 756272002226 Uncharacterized conserved protein [Function unknown]; Region: COG3472 756272002227 Divergent AAA domain; Region: AAA_4; pfam04326 756272002228 DNA polymerase II large subunit; Validated; Region: PRK04023 756272002229 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272002230 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272002231 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272002232 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 756272002233 DNA binding residues [nucleotide binding] 756272002234 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 756272002235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002236 DNA methylase; Region: N6_N4_Mtase; cl17433 756272002237 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 756272002238 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 756272002239 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 756272002240 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 756272002241 ParB-like nuclease domain; Region: ParB; smart00470 756272002242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002243 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 756272002244 DNA methylase; Region: N6_N4_Mtase; pfam01555 756272002245 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272002246 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 756272002247 catalytic residues [active] 756272002248 catalytic nucleophile [active] 756272002249 Recombinase; Region: Recombinase; pfam07508 756272002250 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 756272002251 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 756272002252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002253 binding surface 756272002254 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272002255 TPR motif; other site 756272002256 TPR repeat; Region: TPR_11; pfam13414 756272002257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002258 TPR motif; other site 756272002259 binding surface 756272002260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002261 binding surface 756272002262 TPR motif; other site 756272002263 TPR repeat; Region: TPR_11; pfam13414 756272002264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002265 TPR motif; other site 756272002266 binding surface 756272002267 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272002268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002269 binding surface 756272002270 TPR motif; other site 756272002271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002272 TPR motif; other site 756272002273 binding surface 756272002274 TPR repeat; Region: TPR_11; pfam13414 756272002275 TPR repeat; Region: TPR_11; pfam13414 756272002276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002277 binding surface 756272002278 TPR motif; other site 756272002279 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272002280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272002281 binding surface 756272002282 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272002283 TPR motif; other site 756272002284 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 756272002285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272002286 ATP binding site [chemical binding]; other site 756272002287 Walker A motif; other site 756272002288 Walker B motif; other site 756272002289 arginine finger; other site 756272002290 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 756272002291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 756272002292 Predicted transcriptional regulators [Transcription]; Region: COG1733 756272002293 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 756272002294 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 756272002295 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 756272002296 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 756272002297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272002298 putative DNA binding site [nucleotide binding]; other site 756272002299 putative Zn2+ binding site [ion binding]; other site 756272002300 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 756272002301 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 756272002302 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 756272002303 P loop; other site 756272002304 Nucleotide binding site [chemical binding]; other site 756272002305 DTAP/Switch II; other site 756272002306 Switch I; other site 756272002307 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 756272002308 DTAP/Switch II; other site 756272002309 Switch I; other site 756272002310 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 756272002311 Low molecular weight phosphatase family; Region: LMWPc; cd00115 756272002312 active site 756272002313 Acyltransferase family; Region: Acyl_transf_3; pfam01757 756272002314 GAF domain; Region: GAF_3; pfam13492 756272002315 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 756272002316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272002317 Walker A motif; other site 756272002318 ATP binding site [chemical binding]; other site 756272002319 Walker B motif; other site 756272002320 arginine finger; other site 756272002321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272002322 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 756272002323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272002324 FeS/SAM binding site; other site 756272002325 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 756272002326 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 756272002327 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 756272002328 Substrate binding site; other site 756272002329 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 756272002330 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 756272002331 Carbon starvation protein CstA; Region: CstA; pfam02554 756272002332 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 756272002333 carbon storage regulator; Provisional; Region: PRK01712 756272002334 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 756272002335 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 756272002336 PAS fold; Region: PAS_4; pfam08448 756272002337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002338 PAS domain; Region: PAS_9; pfam13426 756272002339 putative active site [active] 756272002340 heme pocket [chemical binding]; other site 756272002341 PAS fold; Region: PAS_4; pfam08448 756272002342 PAS domain S-box; Region: sensory_box; TIGR00229 756272002343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002344 putative active site [active] 756272002345 heme pocket [chemical binding]; other site 756272002346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272002347 GAF domain; Region: GAF; pfam01590 756272002348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272002349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272002350 dimer interface [polypeptide binding]; other site 756272002351 phosphorylation site [posttranslational modification] 756272002352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272002353 ATP binding site [chemical binding]; other site 756272002354 Mg2+ binding site [ion binding]; other site 756272002355 G-X-G motif; other site 756272002356 Response regulator receiver domain; Region: Response_reg; pfam00072 756272002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272002358 active site 756272002359 phosphorylation site [posttranslational modification] 756272002360 intermolecular recognition site; other site 756272002361 dimerization interface [polypeptide binding]; other site 756272002362 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 756272002363 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 756272002364 protein binding site [polypeptide binding]; other site 756272002365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272002366 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 756272002367 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 756272002368 active site 756272002369 NAD binding site [chemical binding]; other site 756272002370 metal binding site [ion binding]; metal-binding site 756272002371 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 756272002372 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 756272002373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272002374 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272002375 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 756272002376 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272002377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272002378 structural tetrad; other site 756272002379 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272002380 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 756272002381 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272002382 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272002383 PAS fold; Region: PAS_4; pfam08448 756272002384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272002385 putative active site [active] 756272002386 heme pocket [chemical binding]; other site 756272002387 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272002388 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272002389 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272002390 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 756272002391 Leishmanolysin; Region: Peptidase_M8; pfam01457 756272002392 Right handed beta helix region; Region: Beta_helix; pfam13229 756272002393 Right handed beta helix region; Region: Beta_helix; pfam13229 756272002394 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272002395 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 756272002396 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 756272002397 Probable Catalytic site; other site 756272002398 metal-binding site 756272002399 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 756272002400 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 756272002401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272002402 active site 756272002403 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 756272002404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 756272002405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272002406 Walker A/P-loop; other site 756272002407 ATP binding site [chemical binding]; other site 756272002408 Q-loop/lid; other site 756272002409 ABC transporter signature motif; other site 756272002410 Walker B; other site 756272002411 D-loop; other site 756272002412 H-loop/switch region; other site 756272002413 RibD C-terminal domain; Region: RibD_C; cl17279 756272002414 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 756272002415 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 756272002416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 756272002417 DinB family; Region: DinB; cl17821 756272002418 DinB superfamily; Region: DinB_2; pfam12867 756272002419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 756272002420 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 756272002421 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 756272002422 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 756272002423 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 756272002424 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272002425 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272002426 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272002427 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272002428 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272002429 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 756272002430 putative sialic acid transporter; Provisional; Region: PRK12307 756272002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272002432 putative substrate translocation pore; other site 756272002433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272002434 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 756272002435 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 756272002436 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272002437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272002438 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 756272002439 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 756272002440 homodimer interface [polypeptide binding]; other site 756272002441 substrate-cofactor binding pocket; other site 756272002442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272002443 catalytic residue [active] 756272002444 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 756272002445 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272002446 Sulfatase; Region: Sulfatase; pfam00884 756272002447 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272002448 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272002449 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 756272002450 OmpA family; Region: OmpA; pfam00691 756272002451 ligand binding site [chemical binding]; other site 756272002452 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 756272002453 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 756272002454 generic binding surface II; other site 756272002455 ssDNA binding site; other site 756272002456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272002457 ATP binding site [chemical binding]; other site 756272002458 putative Mg++ binding site [ion binding]; other site 756272002459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272002460 nucleotide binding region [chemical binding]; other site 756272002461 ATP-binding site [chemical binding]; other site 756272002462 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272002463 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 756272002464 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 756272002465 DNA binding site [nucleotide binding] 756272002466 catalytic residue [active] 756272002467 H2TH interface [polypeptide binding]; other site 756272002468 putative catalytic residues [active] 756272002469 turnover-facilitating residue; other site 756272002470 intercalation triad [nucleotide binding]; other site 756272002471 8OG recognition residue [nucleotide binding]; other site 756272002472 putative reading head residues; other site 756272002473 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 756272002474 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 756272002475 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 756272002476 CsbD-like; Region: CsbD; pfam05532 756272002477 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 756272002478 Alphavirus E2 glycoprotein; Region: Alpha_E2_glycop; pfam00943 756272002479 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 756272002480 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272002481 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272002482 Sulfatase; Region: Sulfatase; cl17466 756272002483 biotin synthase; Validated; Region: PRK06256 756272002484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272002485 FeS/SAM binding site; other site 756272002486 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 756272002487 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 756272002488 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 756272002489 NAD(P) binding site [chemical binding]; other site 756272002490 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002491 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 756272002492 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 756272002493 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 756272002494 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 756272002495 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 756272002496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272002497 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272002498 NAD(P) binding site [chemical binding]; other site 756272002499 active site 756272002500 glutamine synthetase, type I; Region: GlnA; TIGR00653 756272002501 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 756272002502 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 756272002503 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 756272002504 IHF - DNA interface [nucleotide binding]; other site 756272002505 IHF dimer interface [polypeptide binding]; other site 756272002506 Global regulator protein family; Region: CsrA; pfam02599 756272002507 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 756272002508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272002509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272002510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272002511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272002512 active site 756272002513 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 756272002514 Ubiquitin-like proteins; Region: UBQ; cl00155 756272002515 charged pocket; other site 756272002516 hydrophobic patch; other site 756272002517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 756272002518 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 756272002519 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 756272002520 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 756272002521 PglZ domain; Region: PglZ; pfam08665 756272002522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272002523 nucleotide binding region [chemical binding]; other site 756272002524 ATP-binding site [chemical binding]; other site 756272002525 DNA methylase; Region: N6_N4_Mtase; cl17433 756272002526 AAA domain; Region: AAA_30; pfam13604 756272002527 AAA domain; Region: AAA_22; pfam13401 756272002528 Family description; Region: UvrD_C_2; pfam13538 756272002529 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 756272002530 AAA domain; Region: AAA_14; pfam13173 756272002531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272002532 non-specific DNA binding site [nucleotide binding]; other site 756272002533 salt bridge; other site 756272002534 sequence-specific DNA binding site [nucleotide binding]; other site 756272002535 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 756272002536 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 756272002537 Protein of unknown function, DUF462; Region: DUF462; cl01190 756272002538 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 756272002539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272002540 Walker A motif; other site 756272002541 ATP binding site [chemical binding]; other site 756272002542 Walker B motif; other site 756272002543 arginine finger; other site 756272002544 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 756272002545 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 756272002546 active site 756272002547 Int/Topo IB signature motif; other site 756272002548 DNA binding site [nucleotide binding] 756272002549 DsrE/DsrF-like family; Region: DrsE; pfam02635 756272002550 SprT-like family; Region: SprT-like; pfam10263 756272002551 SprT homologues; Region: SprT; cl01182 756272002552 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 756272002553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272002554 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272002555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272002556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272002557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272002558 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272002559 active site 756272002560 ATP binding site [chemical binding]; other site 756272002561 substrate binding site [chemical binding]; other site 756272002562 activation loop (A-loop); other site 756272002563 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272002564 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272002565 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 756272002566 catalytic residues [active] 756272002567 catalytic nucleophile [active] 756272002568 Recombinase; Region: Recombinase; pfam07508 756272002569 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 756272002570 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 756272002571 Phage Terminase; Region: Terminase_1; pfam03354 756272002572 Terminase-like family; Region: Terminase_6; pfam03237 756272002573 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 756272002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 756272002575 Walker A/P-loop; other site 756272002576 ATP binding site [chemical binding]; other site 756272002577 Q-loop/lid; other site 756272002578 ABC transporter signature motif; other site 756272002579 Walker B; other site 756272002580 D-loop; other site 756272002581 H-loop/switch region; other site 756272002582 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 756272002583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 756272002584 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 756272002585 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 756272002586 ATP binding site [chemical binding]; other site 756272002587 substrate interface [chemical binding]; other site 756272002588 ATP synthase A chain; Region: ATP-synt_A; cl00413 756272002589 ATP synthase subunit C; Region: ATP-synt_C; cl00466 756272002590 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 756272002591 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 756272002592 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 756272002593 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 756272002594 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 756272002595 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 756272002596 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 756272002597 beta subunit interaction interface [polypeptide binding]; other site 756272002598 Walker A motif; other site 756272002599 ATP binding site [chemical binding]; other site 756272002600 Walker B motif; other site 756272002601 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 756272002602 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 756272002603 core domain interface [polypeptide binding]; other site 756272002604 delta subunit interface [polypeptide binding]; other site 756272002605 epsilon subunit interface [polypeptide binding]; other site 756272002606 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 756272002607 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 756272002608 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 756272002609 alpha subunit interaction interface [polypeptide binding]; other site 756272002610 Walker A motif; other site 756272002611 ATP binding site [chemical binding]; other site 756272002612 Walker B motif; other site 756272002613 inhibitor binding site; inhibition site 756272002614 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 756272002615 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 756272002616 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 756272002617 gamma subunit interface [polypeptide binding]; other site 756272002618 epsilon subunit interface [polypeptide binding]; other site 756272002619 LBP interface [polypeptide binding]; other site 756272002620 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 756272002621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272002622 non-specific DNA binding site [nucleotide binding]; other site 756272002623 salt bridge; other site 756272002624 sequence-specific DNA binding site [nucleotide binding]; other site 756272002625 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272002626 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 756272002627 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272002628 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272002629 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272002630 NPCBM/NEW2 domain; Region: NPCBM; cl07060 756272002631 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 756272002632 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272002633 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 756272002634 HEAT repeats; Region: HEAT_2; pfam13646 756272002635 HEAT repeats; Region: HEAT_2; pfam13646 756272002636 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272002637 Cytochrome c; Region: Cytochrom_C; pfam00034 756272002638 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 756272002639 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 756272002640 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272002641 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272002642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272002643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272002644 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272002645 Uncharacterized conserved protein [Function unknown]; Region: COG1432 756272002646 LabA_like proteins; Region: LabA_like/DUF88; cl10034 756272002647 putative metal binding site [ion binding]; other site 756272002648 OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872 756272002649 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002650 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002651 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 756272002652 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 756272002653 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 756272002654 putative active site [active] 756272002655 substrate binding site [chemical binding]; other site 756272002656 putative cosubstrate binding site; other site 756272002657 catalytic site [active] 756272002658 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 756272002659 substrate binding site [chemical binding]; other site 756272002660 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 756272002661 active site 756272002662 catalytic residues [active] 756272002663 metal binding site [ion binding]; metal-binding site 756272002664 glycyl-tRNA synthetase; Provisional; Region: PRK04173 756272002665 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272002666 motif 1; other site 756272002667 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 756272002668 active site 756272002669 motif 2; other site 756272002670 motif 3; other site 756272002671 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 756272002672 anticodon binding site; other site 756272002673 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 756272002674 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 756272002675 endonuclease IV; Provisional; Region: PRK01060 756272002676 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 756272002677 AP (apurinic/apyrimidinic) site pocket; other site 756272002678 DNA interaction; other site 756272002679 Metal-binding active site; metal-binding site 756272002680 hypothetical protein; Provisional; Region: PRK11281 756272002681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272002682 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 756272002683 putative ADP-binding pocket [chemical binding]; other site 756272002684 PQQ-like domain; Region: PQQ_2; pfam13360 756272002685 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272002686 Trp docking motif [polypeptide binding]; other site 756272002687 active site 756272002688 PQQ-like domain; Region: PQQ_2; pfam13360 756272002689 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272002690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272002691 active site 756272002692 ATP binding site [chemical binding]; other site 756272002693 substrate binding site [chemical binding]; other site 756272002694 activation loop (A-loop); other site 756272002695 AAA ATPase domain; Region: AAA_16; pfam13191 756272002696 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002697 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002698 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272002699 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 756272002700 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272002701 Cytochrome c; Region: Cytochrom_C; pfam00034 756272002702 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 756272002703 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 756272002704 putative dimer interface [polypeptide binding]; other site 756272002705 putative anticodon binding site; other site 756272002706 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 756272002707 homodimer interface [polypeptide binding]; other site 756272002708 motif 1; other site 756272002709 motif 2; other site 756272002710 active site 756272002711 motif 3; other site 756272002712 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 756272002713 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 756272002714 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 756272002715 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272002716 protein binding site [polypeptide binding]; other site 756272002717 PA14 domain; Region: PA14; cl08459 756272002718 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 756272002719 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 756272002720 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 756272002721 ligand binding site [chemical binding]; other site 756272002722 dimerization interface [polypeptide binding]; other site 756272002723 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 756272002724 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 756272002725 Walker A/P-loop; other site 756272002726 ATP binding site [chemical binding]; other site 756272002727 Q-loop/lid; other site 756272002728 ABC transporter signature motif; other site 756272002729 Walker B; other site 756272002730 D-loop; other site 756272002731 H-loop/switch region; other site 756272002732 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 756272002733 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 756272002734 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 756272002735 GatB domain; Region: GatB_Yqey; smart00845 756272002736 NAD synthetase; Provisional; Region: PRK13981 756272002737 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 756272002738 multimer interface [polypeptide binding]; other site 756272002739 active site 756272002740 catalytic triad [active] 756272002741 protein interface 1 [polypeptide binding]; other site 756272002742 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 756272002743 homodimer interface [polypeptide binding]; other site 756272002744 NAD binding pocket [chemical binding]; other site 756272002745 ATP binding pocket [chemical binding]; other site 756272002746 Mg binding site [ion binding]; other site 756272002747 active-site loop [active] 756272002748 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 756272002749 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 756272002750 ATP binding site [chemical binding]; other site 756272002751 active site 756272002752 substrate binding site [chemical binding]; other site 756272002753 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 756272002754 ligand binding site [chemical binding]; other site 756272002755 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 756272002756 Peptidase family M28; Region: Peptidase_M28; pfam04389 756272002757 metal binding site [ion binding]; metal-binding site 756272002758 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272002759 Sulfatase; Region: Sulfatase; cl17466 756272002760 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 756272002761 tetramer interfaces [polypeptide binding]; other site 756272002762 binuclear metal-binding site [ion binding]; other site 756272002763 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 756272002764 Trm112p-like protein; Region: Trm112p; pfam03966 756272002765 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272002766 Secretin and TonB N terminus short domain; Region: STN; pfam07660 756272002767 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272002769 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272002770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 756272002771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 756272002772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 756272002773 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 756272002774 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 756272002775 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272002776 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 756272002777 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 756272002778 NAD binding site [chemical binding]; other site 756272002779 homotetramer interface [polypeptide binding]; other site 756272002780 homodimer interface [polypeptide binding]; other site 756272002781 substrate binding site [chemical binding]; other site 756272002782 active site 756272002783 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 756272002784 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 756272002785 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 756272002786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272002787 FeS/SAM binding site; other site 756272002788 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272002789 Substrate binding site [chemical binding]; other site 756272002790 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 756272002791 AIR carboxylase; Region: AIRC; smart01001 756272002792 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 756272002793 active site 756272002794 catalytic residues [active] 756272002795 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 756272002796 MerC mercury resistance protein; Region: MerC; pfam03203 756272002797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272002798 Coenzyme A binding pocket [chemical binding]; other site 756272002799 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 756272002800 active site 756272002801 Protein of unknown function (DUF998); Region: DUF998; pfam06197 756272002802 PQQ-like domain; Region: PQQ_2; pfam13360 756272002803 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272002804 active site 756272002805 Trp docking motif [polypeptide binding]; other site 756272002806 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272002807 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272002808 Trehalose utilisation; Region: ThuA; pfam06283 756272002809 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272002810 PQQ-like domain; Region: PQQ_2; pfam13360 756272002811 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272002812 Trp docking motif [polypeptide binding]; other site 756272002813 active site 756272002814 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272002815 Trp docking motif [polypeptide binding]; other site 756272002816 active site 756272002817 PQQ-like domain; Region: PQQ_2; pfam13360 756272002818 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 756272002819 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 756272002820 intersubunit interface [polypeptide binding]; other site 756272002821 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 756272002822 substrate binding site; other site 756272002823 dimer interface; other site 756272002824 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 756272002825 serine O-acetyltransferase; Region: cysE; TIGR01172 756272002826 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 756272002827 trimer interface [polypeptide binding]; other site 756272002828 active site 756272002829 substrate binding site [chemical binding]; other site 756272002830 CoA binding site [chemical binding]; other site 756272002831 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 756272002832 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 756272002833 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 756272002834 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 756272002835 nucleotide binding site [chemical binding]; other site 756272002836 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 756272002837 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272002838 anti sigma factor interaction site; other site 756272002839 regulatory phosphorylation site [posttranslational modification]; other site 756272002840 Domain of unknown function (DUF368); Region: DUF368; pfam04018 756272002841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 756272002842 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 756272002843 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 756272002844 CAAX protease self-immunity; Region: Abi; pfam02517 756272002845 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 756272002846 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 756272002847 Walker A/P-loop; other site 756272002848 ATP binding site [chemical binding]; other site 756272002849 Q-loop/lid; other site 756272002850 ABC transporter signature motif; other site 756272002851 Walker B; other site 756272002852 D-loop; other site 756272002853 H-loop/switch region; other site 756272002854 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 756272002855 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 756272002856 substrate-cofactor binding pocket; other site 756272002857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272002858 catalytic residue [active] 756272002859 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 756272002860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272002861 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272002862 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 756272002863 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272002864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272002866 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 756272002867 putative ADP-binding pocket [chemical binding]; other site 756272002868 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272002869 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 756272002870 metal-binding site 756272002871 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 756272002872 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 756272002873 NADP binding site [chemical binding]; other site 756272002874 active site 756272002875 putative substrate binding site [chemical binding]; other site 756272002876 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 756272002877 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 756272002878 NADP-binding site; other site 756272002879 homotetramer interface [polypeptide binding]; other site 756272002880 substrate binding site [chemical binding]; other site 756272002881 homodimer interface [polypeptide binding]; other site 756272002882 active site 756272002883 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 756272002884 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 756272002885 dimerization interface 3.5A [polypeptide binding]; other site 756272002886 active site 756272002887 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272002888 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 756272002889 Predicted flavoprotein [General function prediction only]; Region: COG0431 756272002890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 756272002891 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272002892 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 756272002893 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 756272002894 active site 756272002895 HIGH motif; other site 756272002896 KMSKS motif; other site 756272002897 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 756272002898 anticodon binding site; other site 756272002899 tRNA binding surface [nucleotide binding]; other site 756272002900 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 756272002901 dimer interface [polypeptide binding]; other site 756272002902 putative tRNA-binding site [nucleotide binding]; other site 756272002903 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 756272002904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272002905 catalytic residue [active] 756272002906 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 756272002907 BON domain; Region: BON; pfam04972 756272002908 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 756272002909 Mechanosensitive ion channel; Region: MS_channel; pfam00924 756272002910 Domain of unknown function DUF21; Region: DUF21; pfam01595 756272002911 FOG: CBS domain [General function prediction only]; Region: COG0517 756272002912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 756272002913 Transporter associated domain; Region: CorC_HlyC; smart01091 756272002914 Clp protease; Region: CLP_protease; pfam00574 756272002915 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 756272002916 oligomer interface [polypeptide binding]; other site 756272002917 active site residues [active] 756272002918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 756272002919 Clp protease; Region: CLP_protease; pfam00574 756272002920 oligomer interface [polypeptide binding]; other site 756272002921 active site residues [active] 756272002922 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 756272002923 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 756272002924 Catalytic site [active] 756272002925 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 756272002926 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 756272002927 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 756272002928 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 756272002929 Recombination protein O N terminal; Region: RecO_N; pfam11967 756272002930 Recombination protein O C terminal; Region: RecO_C; pfam02565 756272002931 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 756272002932 UbiA prenyltransferase family; Region: UbiA; pfam01040 756272002933 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 756272002934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272002935 FeS/SAM binding site; other site 756272002936 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 756272002937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272002938 dimer interface [polypeptide binding]; other site 756272002939 putative metal binding site [ion binding]; other site 756272002940 argininosuccinate lyase; Provisional; Region: PRK00855 756272002941 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 756272002942 active sites [active] 756272002943 tetramer interface [polypeptide binding]; other site 756272002944 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 756272002945 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272002946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272002947 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272002948 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 756272002949 Bacterial sugar transferase; Region: Bac_transf; pfam02397 756272002950 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272002951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272002952 S-adenosylmethionine binding site [chemical binding]; other site 756272002953 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 756272002954 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 756272002955 Ligand binding site; other site 756272002956 Putative Catalytic site; other site 756272002957 DXD motif; other site 756272002958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272002959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 756272002960 active site 756272002961 OsmC-like protein; Region: OsmC; pfam02566 756272002962 Peptidase family M48; Region: Peptidase_M48; pfam01435 756272002963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272002964 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 756272002965 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 756272002966 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 756272002967 FeoA domain; Region: FeoA; pfam04023 756272002968 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 756272002969 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 756272002970 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272002971 active site 756272002972 ATP binding site [chemical binding]; other site 756272002973 substrate binding site [chemical binding]; other site 756272002974 activation loop (A-loop); other site 756272002975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 756272002976 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272002977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272002978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272002979 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 756272002980 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 756272002981 homoserine dehydrogenase; Provisional; Region: PRK06349 756272002982 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 756272002983 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 756272002984 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 756272002985 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272002986 Sulfatase; Region: Sulfatase; pfam00884 756272002987 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272002988 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272002989 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272002990 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272002991 Cupin domain; Region: Cupin_2; pfam07883 756272002992 Transcriptional regulators [Transcription]; Region: MarR; COG1846 756272002993 MarR family; Region: MarR_2; pfam12802 756272002994 Glucokinase; Region: Glucokinase; pfam02685 756272002995 glucokinase, proteobacterial type; Region: glk; TIGR00749 756272002996 fumarate hydratase; Reviewed; Region: fumC; PRK00485 756272002997 Class II fumarases; Region: Fumarase_classII; cd01362 756272002998 active site 756272002999 tetramer interface [polypeptide binding]; other site 756272003000 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 756272003001 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 756272003002 oligomeric interface; other site 756272003003 putative active site [active] 756272003004 homodimer interface [polypeptide binding]; other site 756272003005 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 756272003006 KpsF/GutQ family protein; Region: kpsF; TIGR00393 756272003007 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 756272003008 putative active site [active] 756272003009 CBS domain; Region: CBS; pfam00571 756272003010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 756272003011 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 756272003012 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 756272003013 Ligand Binding Site [chemical binding]; other site 756272003014 HEAT repeats; Region: HEAT_2; pfam13646 756272003015 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 756272003016 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 756272003017 Global regulator protein family; Region: CsrA; pfam02599 756272003018 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272003019 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272003020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 756272003021 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272003022 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272003023 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272003024 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272003025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003026 TPR motif; other site 756272003027 binding surface 756272003028 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 756272003029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003030 binding surface 756272003031 TPR motif; other site 756272003032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003033 binding surface 756272003034 TPR motif; other site 756272003035 TPR repeat; Region: TPR_11; pfam13414 756272003036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003037 binding surface 756272003038 TPR motif; other site 756272003039 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272003040 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 756272003041 active site 756272003042 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 756272003043 homotrimer interaction site [polypeptide binding]; other site 756272003044 putative active site [active] 756272003045 recombination factor protein RarA; Reviewed; Region: PRK13342 756272003046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003047 Walker A motif; other site 756272003048 ATP binding site [chemical binding]; other site 756272003049 Walker B motif; other site 756272003050 arginine finger; other site 756272003051 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 756272003052 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272003053 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272003054 Metal-binding active site; metal-binding site 756272003055 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 756272003056 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 756272003057 glutaminase active site [active] 756272003058 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 756272003059 dimer interface [polypeptide binding]; other site 756272003060 active site 756272003061 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 756272003062 dimer interface [polypeptide binding]; other site 756272003063 active site 756272003064 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003065 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 756272003066 feedback inhibition sensing region; other site 756272003067 homohexameric interface [polypeptide binding]; other site 756272003068 nucleotide binding site [chemical binding]; other site 756272003069 N-acetyl-L-glutamate binding site [chemical binding]; other site 756272003070 acetylornithine aminotransferase; Provisional; Region: PRK02627 756272003071 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 756272003072 inhibitor-cofactor binding pocket; inhibition site 756272003073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272003074 catalytic residue [active] 756272003075 ornithine carbamoyltransferase; Provisional; Region: PRK00779 756272003076 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 756272003077 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 756272003078 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 756272003079 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 756272003080 purine monophosphate binding site [chemical binding]; other site 756272003081 dimer interface [polypeptide binding]; other site 756272003082 putative catalytic residues [active] 756272003083 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 756272003084 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 756272003085 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272003086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272003087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272003088 Domain of unknown function DUF11; Region: DUF11; cl17728 756272003089 PQQ-like domain; Region: PQQ_2; pfam13360 756272003090 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272003091 Trp docking motif [polypeptide binding]; other site 756272003092 active site 756272003093 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272003094 GAF domain; Region: GAF; pfam01590 756272003095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272003096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003097 active site 756272003098 phosphorylation site [posttranslational modification] 756272003099 intermolecular recognition site; other site 756272003100 dimerization interface [polypeptide binding]; other site 756272003101 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 756272003102 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 756272003103 FHIPEP family; Region: FHIPEP; pfam00771 756272003104 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 756272003105 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272003106 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 756272003107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272003108 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 756272003109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272003110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272003111 DNA binding residues [nucleotide binding] 756272003112 BNR repeat-like domain; Region: BNR_2; pfam13088 756272003113 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 756272003114 catalytic site [active] 756272003115 Asp-box motif; other site 756272003116 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 756272003117 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003119 binding surface 756272003120 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272003121 TPR motif; other site 756272003122 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272003123 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 756272003124 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 756272003125 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 756272003126 Uncharacterized conserved protein [Function unknown]; Region: COG4717 756272003127 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272003128 metal binding site [ion binding]; metal-binding site 756272003129 Protein of unknown function DUF58; Region: DUF58; pfam01882 756272003130 pteridine reductase; Provisional; Region: PRK09135 756272003131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272003132 NAD(P) binding site [chemical binding]; other site 756272003133 active site 756272003134 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 756272003135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 756272003136 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 756272003137 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 756272003138 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 756272003139 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 756272003140 intersubunit interface [polypeptide binding]; other site 756272003141 Ycf46; Provisional; Region: ycf46; CHL00195 756272003142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003143 Walker A motif; other site 756272003144 ATP binding site [chemical binding]; other site 756272003145 Walker B motif; other site 756272003146 arginine finger; other site 756272003147 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 756272003148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272003149 S-adenosylmethionine binding site [chemical binding]; other site 756272003150 DNA polymerase I; Provisional; Region: PRK05755 756272003151 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 756272003152 active site 756272003153 metal binding site 1 [ion binding]; metal-binding site 756272003154 putative 5' ssDNA interaction site; other site 756272003155 metal binding site 3; metal-binding site 756272003156 metal binding site 2 [ion binding]; metal-binding site 756272003157 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 756272003158 putative DNA binding site [nucleotide binding]; other site 756272003159 putative metal binding site [ion binding]; other site 756272003160 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 756272003161 active site 756272003162 catalytic site [active] 756272003163 substrate binding site [chemical binding]; other site 756272003164 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 756272003165 active site 756272003166 DNA binding site [nucleotide binding] 756272003167 catalytic site [active] 756272003168 Ion transport protein; Region: Ion_trans; pfam00520 756272003169 Ion channel; Region: Ion_trans_2; pfam07885 756272003170 Uncharacterized conserved protein [Function unknown]; Region: COG0327 756272003171 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 756272003172 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272003173 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272003174 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 756272003175 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 756272003176 active site 756272003177 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 756272003178 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 756272003179 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 756272003180 Walker A/P-loop; other site 756272003181 ATP binding site [chemical binding]; other site 756272003182 Q-loop/lid; other site 756272003183 ABC transporter signature motif; other site 756272003184 Walker B; other site 756272003185 D-loop; other site 756272003186 H-loop/switch region; other site 756272003187 peptidase T; Region: peptidase-T; TIGR01882 756272003188 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 756272003189 metal binding site [ion binding]; metal-binding site 756272003190 dimer interface [polypeptide binding]; other site 756272003191 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 756272003192 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 756272003193 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 756272003194 metal ion-dependent adhesion site (MIDAS); other site 756272003195 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 756272003196 TadE-like protein; Region: TadE; pfam07811 756272003197 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 756272003198 TadE-like protein; Region: TadE; pfam07811 756272003199 PhoD-like phosphatase; Region: PhoD; pfam09423 756272003200 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 756272003201 putative active site [active] 756272003202 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272003203 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 756272003204 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 756272003205 FMN binding site [chemical binding]; other site 756272003206 active site 756272003207 catalytic residues [active] 756272003208 substrate binding site [chemical binding]; other site 756272003209 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 756272003210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272003211 Zn2+ binding site [ion binding]; other site 756272003212 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 756272003213 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 756272003214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 756272003215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 756272003216 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 756272003217 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 756272003218 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 756272003219 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 756272003220 HsdM N-terminal domain; Region: HsdM_N; pfam12161 756272003221 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 756272003222 Methyltransferase domain; Region: Methyltransf_26; pfam13659 756272003223 ParB-like nuclease domain; Region: ParBc; pfam02195 756272003224 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272003225 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272003226 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272003227 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 756272003228 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272003229 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272003230 calcium mediated ligand binding site; other site 756272003231 intermolecular salt bridges; other site 756272003232 Mu-like prophage protein [General function prediction only]; Region: COG3941 756272003233 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 756272003234 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 756272003235 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 756272003236 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 756272003237 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 756272003238 Phage capsid family; Region: Phage_capsid; pfam05065 756272003239 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 756272003240 Phage portal protein; Region: Phage_portal; pfam04860 756272003241 Phage-related protein [Function unknown]; Region: COG4695; cl01923 756272003242 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 756272003243 Phage terminase, small subunit; Region: Terminase_4; pfam05119 756272003244 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 756272003245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 756272003246 active site 756272003247 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272003248 catalytic residues [active] 756272003249 Int/Topo IB signature motif; other site 756272003250 DNA binding site [nucleotide binding] 756272003251 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 756272003252 active site 756272003253 catalytic residues [active] 756272003254 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 756272003255 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 756272003256 active site clefts [active] 756272003257 zinc binding site [ion binding]; other site 756272003258 dimer interface [polypeptide binding]; other site 756272003259 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 756272003260 Protein of unknown function DUF91; Region: DUF91; cl00709 756272003261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272003262 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 756272003263 Coenzyme A binding pocket [chemical binding]; other site 756272003264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272003265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272003266 active site 756272003267 ATP binding site [chemical binding]; other site 756272003268 substrate binding site [chemical binding]; other site 756272003269 activation loop (A-loop); other site 756272003270 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003271 Cytochrome c [Energy production and conversion]; Region: COG3258 756272003272 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 756272003273 DinB family; Region: DinB; cl17821 756272003274 DinB superfamily; Region: DinB_2; pfam12867 756272003275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 756272003276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 756272003277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 756272003278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 756272003279 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 756272003280 SnoaL-like domain; Region: SnoaL_2; pfam12680 756272003281 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003282 Sulfatase; Region: Sulfatase; pfam00884 756272003283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272003284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272003285 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 756272003286 putative hydrolase; Provisional; Region: PRK02113 756272003287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003288 binding surface 756272003289 TPR motif; other site 756272003290 TPR repeat; Region: TPR_11; pfam13414 756272003291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003292 binding surface 756272003293 Tetratricopeptide repeat; Region: TPR_9; pfam13371 756272003294 TPR motif; other site 756272003295 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 756272003296 Protein of unknown function DUF58; Region: DUF58; pfam01882 756272003297 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 756272003298 metal ion-dependent adhesion site (MIDAS); other site 756272003299 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272003300 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272003301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003302 TPR motif; other site 756272003303 binding surface 756272003304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272003305 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 756272003306 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 756272003307 active site 756272003308 PHP Thumb interface [polypeptide binding]; other site 756272003309 metal binding site [ion binding]; metal-binding site 756272003310 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 756272003311 generic binding surface II; other site 756272003312 generic binding surface I; other site 756272003313 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003314 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 756272003315 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 756272003316 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 756272003317 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 756272003318 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 756272003319 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 756272003320 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272003321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 756272003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003323 active site 756272003324 phosphorylation site [posttranslational modification] 756272003325 intermolecular recognition site; other site 756272003326 dimerization interface [polypeptide binding]; other site 756272003327 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 756272003328 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 756272003329 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 756272003330 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272003331 Trp docking motif [polypeptide binding]; other site 756272003332 PQQ-like domain; Region: PQQ_2; pfam13360 756272003333 active site 756272003334 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 756272003335 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272003336 putative catalytic residue [active] 756272003337 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 756272003338 Global regulator protein family; Region: CsrA; pfam02599 756272003339 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 756272003340 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 756272003341 Class I aldolases; Region: Aldolase_Class_I; cl17187 756272003342 catalytic residue [active] 756272003343 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272003344 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 756272003345 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 756272003346 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272003347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003348 binding surface 756272003349 TPR repeat; Region: TPR_11; pfam13414 756272003350 TPR motif; other site 756272003351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272003352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272003353 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 756272003354 nucleoside/Zn binding site; other site 756272003355 dimer interface [polypeptide binding]; other site 756272003356 catalytic motif [active] 756272003357 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 756272003358 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 756272003359 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 756272003360 helicase 45; Provisional; Region: PTZ00424 756272003361 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 756272003362 ATP binding site [chemical binding]; other site 756272003363 Mg++ binding site [ion binding]; other site 756272003364 motif III; other site 756272003365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272003366 nucleotide binding region [chemical binding]; other site 756272003367 ATP-binding site [chemical binding]; other site 756272003368 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003369 Sulfatase; Region: Sulfatase; pfam00884 756272003370 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 756272003371 putative active site pocket [active] 756272003372 dimerization interface [polypeptide binding]; other site 756272003373 putative catalytic residue [active] 756272003374 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 756272003375 putative NAD(P) binding site [chemical binding]; other site 756272003376 active site 756272003377 putative substrate binding site [chemical binding]; other site 756272003378 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 756272003379 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 756272003380 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 756272003381 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 756272003382 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 756272003383 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 756272003384 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 756272003385 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 756272003386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 756272003387 catalytic loop [active] 756272003388 iron binding site [ion binding]; other site 756272003389 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 756272003390 FAD binding pocket [chemical binding]; other site 756272003391 FAD binding motif [chemical binding]; other site 756272003392 phosphate binding motif [ion binding]; other site 756272003393 beta-alpha-beta structure motif; other site 756272003394 NAD binding pocket [chemical binding]; other site 756272003395 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 756272003396 ApbE family; Region: ApbE; pfam02424 756272003397 Protein of unknown function (DUF539); Region: DUF539; cl01129 756272003398 Predicted dehydrogenase [General function prediction only]; Region: COG0579 756272003399 hydroxyglutarate oxidase; Provisional; Region: PRK11728 756272003400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272003401 dimerization interface [polypeptide binding]; other site 756272003402 putative DNA binding site [nucleotide binding]; other site 756272003403 putative Zn2+ binding site [ion binding]; other site 756272003404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 756272003405 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 756272003406 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 756272003407 Domain of unknown function DUF20; Region: UPF0118; pfam01594 756272003408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 756272003409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272003410 Coenzyme A binding pocket [chemical binding]; other site 756272003411 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 756272003412 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 756272003413 multifunctional aminopeptidase A; Provisional; Region: PRK00913 756272003414 interface (dimer of trimers) [polypeptide binding]; other site 756272003415 Substrate-binding/catalytic site; other site 756272003416 Zn-binding sites [ion binding]; other site 756272003417 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 756272003418 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 756272003419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 756272003420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 756272003421 Walker A/P-loop; other site 756272003422 ATP binding site [chemical binding]; other site 756272003423 Q-loop/lid; other site 756272003424 ABC transporter signature motif; other site 756272003425 Walker B; other site 756272003426 D-loop; other site 756272003427 H-loop/switch region; other site 756272003428 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 756272003429 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 756272003430 DHH family; Region: DHH; pfam01368 756272003431 DHHA1 domain; Region: DHHA1; pfam02272 756272003432 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 756272003433 putative hydrophobic ligand binding site [chemical binding]; other site 756272003434 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 756272003435 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 756272003436 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 756272003437 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 756272003438 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 756272003439 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 756272003440 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 756272003441 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 756272003442 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 756272003443 Ligand binding site; other site 756272003444 Putative Catalytic site; other site 756272003445 DXD motif; other site 756272003446 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 756272003447 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 756272003448 active site 756272003449 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272003450 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272003451 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272003452 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272003453 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 756272003454 molybdopterin cofactor binding site; other site 756272003455 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 756272003456 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 756272003457 putative ribose interaction site [chemical binding]; other site 756272003458 putative ADP binding site [chemical binding]; other site 756272003459 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 756272003460 active site 756272003461 nucleotide binding site [chemical binding]; other site 756272003462 HIGH motif; other site 756272003463 KMSKS motif; other site 756272003464 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 756272003465 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 756272003466 putative active site [active] 756272003467 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003468 Sulfatase; Region: Sulfatase; pfam00884 756272003469 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 756272003470 DNA binding residues [nucleotide binding] 756272003471 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272003472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 756272003473 active site 756272003474 phosphorylation site [posttranslational modification] 756272003475 intermolecular recognition site; other site 756272003476 dimerization interface [polypeptide binding]; other site 756272003477 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 756272003478 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 756272003479 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272003480 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 756272003481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003482 TPR motif; other site 756272003483 binding surface 756272003484 Tetratricopeptide repeat; Region: TPR_9; pfam13371 756272003485 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272003486 Peptidase family C4; Region: Peptidase_C4; pfam00863 756272003487 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272003488 protein binding site [polypeptide binding]; other site 756272003489 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 756272003490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 756272003491 catalytic core [active] 756272003492 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 756272003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 756272003494 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003495 Sulfatase; Region: Sulfatase; pfam00884 756272003496 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003497 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272003498 active site 756272003499 PQQ-like domain; Region: PQQ_2; pfam13360 756272003500 Trp docking motif [polypeptide binding]; other site 756272003501 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272003502 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003503 Sulfatase; Region: Sulfatase; pfam00884 756272003504 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 756272003505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272003506 motif II; other site 756272003507 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 756272003508 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 756272003509 inhibitor-cofactor binding pocket; inhibition site 756272003510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272003511 catalytic residue [active] 756272003512 Bacterial sugar transferase; Region: Bac_transf; pfam02397 756272003513 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 756272003514 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 756272003515 putative trimer interface [polypeptide binding]; other site 756272003516 putative CoA binding site [chemical binding]; other site 756272003517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272003518 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 756272003519 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 756272003520 active site 756272003521 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 756272003522 homodimer interface [polypeptide binding]; other site 756272003523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272003524 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272003525 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 756272003526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 756272003527 acyl-activating enzyme (AAE) consensus motif; other site 756272003528 active site 756272003529 AMP binding site [chemical binding]; other site 756272003530 CoA binding site [chemical binding]; other site 756272003531 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 756272003532 putative trimer interface [polypeptide binding]; other site 756272003533 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 756272003534 putative CoA binding site [chemical binding]; other site 756272003535 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 756272003536 putative trimer interface [polypeptide binding]; other site 756272003537 putative active site [active] 756272003538 putative substrate binding site [chemical binding]; other site 756272003539 putative CoA binding site [chemical binding]; other site 756272003540 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272003541 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272003542 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272003543 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 756272003544 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 756272003545 inhibitor-cofactor binding pocket; inhibition site 756272003546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272003547 catalytic residue [active] 756272003548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272003549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272003550 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272003551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272003552 metal ion-dependent adhesion site (MIDAS); other site 756272003553 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 756272003554 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272003555 metal ion-dependent adhesion site (MIDAS); other site 756272003556 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272003557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003558 active site 756272003559 phosphorylation site [posttranslational modification] 756272003560 intermolecular recognition site; other site 756272003561 dimerization interface [polypeptide binding]; other site 756272003562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003563 Walker A motif; other site 756272003564 ATP binding site [chemical binding]; other site 756272003565 Walker B motif; other site 756272003566 arginine finger; other site 756272003567 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272003568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272003569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 756272003570 dimerization interface [polypeptide binding]; other site 756272003571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272003572 dimer interface [polypeptide binding]; other site 756272003573 phosphorylation site [posttranslational modification] 756272003574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272003575 ATP binding site [chemical binding]; other site 756272003576 G-X-G motif; other site 756272003577 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003578 TrkA-C domain; Region: TrkA_C; pfam02080 756272003579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272003580 PAS fold; Region: PAS_3; pfam08447 756272003581 putative active site [active] 756272003582 heme pocket [chemical binding]; other site 756272003583 PAS domain S-box; Region: sensory_box; TIGR00229 756272003584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272003585 putative active site [active] 756272003586 heme pocket [chemical binding]; other site 756272003587 PAS domain; Region: PAS_9; pfam13426 756272003588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272003589 putative active site [active] 756272003590 heme pocket [chemical binding]; other site 756272003591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272003592 PAS domain; Region: PAS_9; pfam13426 756272003593 putative active site [active] 756272003594 heme pocket [chemical binding]; other site 756272003595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272003596 dimer interface [polypeptide binding]; other site 756272003597 phosphorylation site [posttranslational modification] 756272003598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272003599 ATP binding site [chemical binding]; other site 756272003600 Mg2+ binding site [ion binding]; other site 756272003601 G-X-G motif; other site 756272003602 Response regulator receiver domain; Region: Response_reg; pfam00072 756272003603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272003604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003605 active site 756272003606 phosphorylation site [posttranslational modification] 756272003607 intermolecular recognition site; other site 756272003608 dimerization interface [polypeptide binding]; other site 756272003609 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 756272003610 GH3 auxin-responsive promoter; Region: GH3; pfam03321 756272003611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 756272003612 glycerol kinase; Provisional; Region: glpK; PRK00047 756272003613 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 756272003614 N- and C-terminal domain interface [polypeptide binding]; other site 756272003615 active site 756272003616 MgATP binding site [chemical binding]; other site 756272003617 catalytic site [active] 756272003618 metal binding site [ion binding]; metal-binding site 756272003619 glycerol binding site [chemical binding]; other site 756272003620 homotetramer interface [polypeptide binding]; other site 756272003621 homodimer interface [polypeptide binding]; other site 756272003622 FBP binding site [chemical binding]; other site 756272003623 protein IIAGlc interface [polypeptide binding]; other site 756272003624 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 756272003625 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003626 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 756272003627 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272003629 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 756272003630 Trehalase; Region: Trehalase; cl17346 756272003631 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 756272003632 MPT binding site; other site 756272003633 trimer interface [polypeptide binding]; other site 756272003634 HEAT repeats; Region: HEAT_2; pfam13646 756272003635 HEAT repeats; Region: HEAT_2; pfam13646 756272003636 TPR repeat; Region: TPR_11; pfam13414 756272003637 TPR repeat; Region: TPR_11; pfam13414 756272003638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003639 binding surface 756272003640 TPR motif; other site 756272003641 TPR repeat; Region: TPR_11; pfam13414 756272003642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003643 binding surface 756272003644 TPR motif; other site 756272003645 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 756272003646 dimer interface [polypeptide binding]; other site 756272003647 active site 756272003648 ADP-ribose binding site [chemical binding]; other site 756272003649 nudix motif; other site 756272003650 metal binding site [ion binding]; metal-binding site 756272003651 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 756272003652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272003653 putative catalytic residue [active] 756272003654 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 756272003655 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 756272003656 active site 756272003657 (T/H)XGH motif; other site 756272003658 PAS fold; Region: PAS_4; pfam08448 756272003659 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 756272003660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272003661 dimer interface [polypeptide binding]; other site 756272003662 phosphorylation site [posttranslational modification] 756272003663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272003664 ATP binding site [chemical binding]; other site 756272003665 Mg2+ binding site [ion binding]; other site 756272003666 G-X-G motif; other site 756272003667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272003668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003669 active site 756272003670 phosphorylation site [posttranslational modification] 756272003671 intermolecular recognition site; other site 756272003672 dimerization interface [polypeptide binding]; other site 756272003673 Type II/IV secretion system protein; Region: T2SE; pfam00437 756272003674 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 756272003675 Walker A motif; other site 756272003676 ATP binding site [chemical binding]; other site 756272003677 Walker B motif; other site 756272003678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003679 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 756272003680 Walker A motif; other site 756272003681 ATP binding site [chemical binding]; other site 756272003682 Walker B motif; other site 756272003683 arginine finger; other site 756272003684 PSP1 C-terminal conserved region; Region: PSP1; cl00770 756272003685 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 756272003686 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 756272003687 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272003688 Leucine-rich repeats; other site 756272003689 Leucine rich repeat; Region: LRR_8; pfam13855 756272003690 Substrate binding site [chemical binding]; other site 756272003691 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 756272003692 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 756272003693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272003694 NAD(P) binding site [chemical binding]; other site 756272003695 active site 756272003696 elongation factor G; Reviewed; Region: PRK00007 756272003697 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 756272003698 G1 box; other site 756272003699 putative GEF interaction site [polypeptide binding]; other site 756272003700 GTP/Mg2+ binding site [chemical binding]; other site 756272003701 Switch I region; other site 756272003702 G2 box; other site 756272003703 G3 box; other site 756272003704 Switch II region; other site 756272003705 G4 box; other site 756272003706 G5 box; other site 756272003707 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 756272003708 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 756272003709 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 756272003710 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272003711 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272003712 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272003713 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272003714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003715 binding surface 756272003716 TPR motif; other site 756272003717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272003718 binding surface 756272003719 TPR motif; other site 756272003720 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 756272003721 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 756272003722 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 756272003723 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003724 Sulfatase; Region: Sulfatase; pfam00884 756272003725 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 756272003726 SnoaL-like domain; Region: SnoaL_3; pfam13474 756272003727 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003728 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 756272003729 NAD(P) binding site [chemical binding]; other site 756272003730 catalytic residues [active] 756272003731 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 756272003732 Disaggregatase related; Region: Disaggr_assoc; pfam08480 756272003733 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 756272003734 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272003735 Protein of unknown function (DUF962); Region: DUF962; cl01879 756272003736 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272003737 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272003738 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272003739 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272003740 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003741 Sulfatase; Region: Sulfatase; pfam00884 756272003742 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 756272003743 active site 756272003744 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003745 Sulfatase; Region: Sulfatase; pfam00884 756272003746 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 756272003747 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 756272003748 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 756272003749 Uncharacterized conserved protein [Function unknown]; Region: COG2308 756272003750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 756272003751 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 756272003752 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 756272003753 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 756272003754 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 756272003755 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 756272003756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 756272003757 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 756272003758 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 756272003759 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 756272003760 putative major fimbrial protein SthE; Provisional; Region: PRK15292 756272003761 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 756272003762 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 756272003763 AAA domain; Region: AAA_31; pfam13614 756272003764 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 756272003765 P-loop; other site 756272003766 Magnesium ion binding site [ion binding]; other site 756272003767 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 756272003768 Magnesium ion binding site [ion binding]; other site 756272003769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272003770 active site residue [active] 756272003771 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 756272003772 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 756272003773 GTP-binding protein YchF; Reviewed; Region: PRK09601 756272003774 YchF GTPase; Region: YchF; cd01900 756272003775 G1 box; other site 756272003776 GTP/Mg2+ binding site [chemical binding]; other site 756272003777 Switch I region; other site 756272003778 G2 box; other site 756272003779 Switch II region; other site 756272003780 G3 box; other site 756272003781 G4 box; other site 756272003782 G5 box; other site 756272003783 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 756272003784 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272003785 putative catalytic site [active] 756272003786 putative metal binding site [ion binding]; other site 756272003787 putative phosphate binding site [ion binding]; other site 756272003788 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 756272003789 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 756272003790 active site 756272003791 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 756272003792 Sulfatase; Region: Sulfatase; cl17466 756272003793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003794 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003795 Sulfatase; Region: Sulfatase; cl17466 756272003796 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272003797 Sulfatase; Region: Sulfatase; cl17466 756272003798 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272003799 active site 756272003800 ATP binding site [chemical binding]; other site 756272003801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272003802 substrate binding site [chemical binding]; other site 756272003803 activation loop (A-loop); other site 756272003804 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272003805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272003806 binding surface 756272003807 TPR motif; other site 756272003808 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 756272003809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272003810 metal ion-dependent adhesion site (MIDAS); other site 756272003811 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 756272003812 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272003813 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003814 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 756272003815 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 756272003816 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 756272003817 putative active site [active] 756272003818 catalytic site [active] 756272003819 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 756272003820 putative active site [active] 756272003821 catalytic site [active] 756272003822 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 756272003823 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 756272003824 active site 756272003825 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 756272003826 Transposase IS200 like; Region: Y1_Tnp; cl00848 756272003827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 756272003828 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272003829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272003830 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272003831 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272003832 PQQ-like domain; Region: PQQ_2; pfam13360 756272003833 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272003834 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272003835 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272003836 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272003837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272003838 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272003839 substrate binding pocket [chemical binding]; other site 756272003840 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272003841 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 756272003842 phosphopeptide binding site; other site 756272003843 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 756272003844 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 756272003845 Protein of unknown function (DUF770); Region: DUF770; pfam05591 756272003846 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 756272003847 Protein of unknown function (DUF877); Region: DUF877; pfam05943 756272003848 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 756272003849 Protein of unknown function (DUF877); Region: DUF877; pfam05943 756272003850 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 756272003851 ImpE protein; Region: ImpE; pfam07024 756272003852 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 756272003853 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 756272003854 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 756272003855 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 756272003856 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 756272003857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003858 Walker A motif; other site 756272003859 ATP binding site [chemical binding]; other site 756272003860 Walker B motif; other site 756272003861 arginine finger; other site 756272003862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272003863 Walker A motif; other site 756272003864 ATP binding site [chemical binding]; other site 756272003865 Walker B motif; other site 756272003866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 756272003867 Protein of unknown function (DUF796); Region: DUF796; pfam05638 756272003868 Protein of unknown function (DUF796); Region: DUF796; cl01226 756272003869 Protein of unknown function (DUF796); Region: DUF796; pfam05638 756272003870 Protein of unknown function (DUF796); Region: DUF796; cl01226 756272003871 Protein of unknown function (DUF796); Region: DUF796; pfam05638 756272003872 Protein of unknown function (DUF796); Region: DUF796; pfam05638 756272003873 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 756272003874 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 756272003875 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 756272003876 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 756272003877 PAAR motif; Region: PAAR_motif; pfam05488 756272003878 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 756272003879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272003880 S-adenosylmethionine binding site [chemical binding]; other site 756272003881 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 756272003882 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 756272003883 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 756272003884 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 756272003885 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 756272003886 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 756272003887 CsbD-like; Region: CsbD; cl17424 756272003888 short chain dehydrogenase; Provisional; Region: PRK06701 756272003889 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 756272003890 NAD binding site [chemical binding]; other site 756272003891 metal binding site [ion binding]; metal-binding site 756272003892 active site 756272003893 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 756272003894 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 756272003895 G1 box; other site 756272003896 GTP/Mg2+ binding site [chemical binding]; other site 756272003897 G2 box; other site 756272003898 Switch I region; other site 756272003899 G3 box; other site 756272003900 Switch II region; other site 756272003901 G4 box; other site 756272003902 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 756272003903 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 756272003904 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272003905 anti sigma factor interaction site; other site 756272003906 regulatory phosphorylation site [posttranslational modification]; other site 756272003907 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 756272003908 thymidylate kinase; Provisional; Region: PRK13975; cl17243 756272003909 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 756272003910 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272003911 catalytic triad [active] 756272003912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 756272003913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 756272003914 metal binding site [ion binding]; metal-binding site 756272003915 active site 756272003916 I-site; other site 756272003917 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 756272003918 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 756272003919 TrkA-C domain; Region: TrkA_C; pfam02080 756272003920 TrkA-C domain; Region: TrkA_C; pfam02080 756272003921 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 756272003922 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 756272003923 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 756272003924 active site 756272003925 putative lithium-binding site [ion binding]; other site 756272003926 substrate binding site [chemical binding]; other site 756272003927 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 756272003928 Ligand binding site; other site 756272003929 Putative Catalytic site; other site 756272003930 DXD motif; other site 756272003931 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 756272003932 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 756272003933 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 756272003934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272003935 S-adenosylmethionine binding site [chemical binding]; other site 756272003936 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 756272003937 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 756272003938 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 756272003939 metal binding site [ion binding]; metal-binding site 756272003940 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272003941 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 756272003942 Amidohydrolase; Region: Amidohydro_4; pfam13147 756272003943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 756272003944 active site 756272003945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272003946 Coenzyme A binding pocket [chemical binding]; other site 756272003947 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 756272003948 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 756272003949 MOSC domain; Region: MOSC; pfam03473 756272003950 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 756272003951 putative ADP-ribose binding site [chemical binding]; other site 756272003952 putative active site [active] 756272003953 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 756272003954 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 756272003955 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 756272003956 Response regulator receiver domain; Region: Response_reg; pfam00072 756272003957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003958 active site 756272003959 phosphorylation site [posttranslational modification] 756272003960 intermolecular recognition site; other site 756272003961 dimerization interface [polypeptide binding]; other site 756272003962 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 756272003963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272003964 active site 756272003965 phosphorylation site [posttranslational modification] 756272003966 intermolecular recognition site; other site 756272003967 dimerization interface [polypeptide binding]; other site 756272003968 CheB methylesterase; Region: CheB_methylest; pfam01339 756272003969 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 756272003970 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 756272003971 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 756272003972 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 756272003973 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 756272003974 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 756272003975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 756272003976 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 756272003977 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 756272003978 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272003979 O-Antigen ligase; Region: Wzy_C; pfam04932 756272003980 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 756272003981 Chain length determinant protein; Region: Wzz; pfam02706 756272003982 Chain length determinant protein; Region: Wzz; cl15801 756272003983 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 756272003984 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272003985 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 756272003986 SLBB domain; Region: SLBB; pfam10531 756272003987 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 756272003988 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272003989 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 756272003990 UbiA prenyltransferase family; Region: UbiA; pfam01040 756272003991 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 756272003992 Competence protein; Region: Competence; pfam03772 756272003993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 756272003994 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272003995 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272003996 Metal-binding active site; metal-binding site 756272003997 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 756272003998 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 756272003999 transmembrane helices; other site 756272004000 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272004001 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 756272004002 lipoyl synthase; Provisional; Region: PRK05481 756272004003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272004004 FeS/SAM binding site; other site 756272004005 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 756272004006 E3 interaction surface; other site 756272004007 lipoyl attachment site [posttranslational modification]; other site 756272004008 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 756272004009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272004010 ATP-grasp domain; Region: ATP-grasp; pfam02222 756272004011 AIR carboxylase; Region: AIRC; pfam00731 756272004012 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 756272004013 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 756272004014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 756272004015 dimerization interface [polypeptide binding]; other site 756272004016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272004017 dimer interface [polypeptide binding]; other site 756272004018 phosphorylation site [posttranslational modification] 756272004019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272004020 ATP binding site [chemical binding]; other site 756272004021 Mg2+ binding site [ion binding]; other site 756272004022 G-X-G motif; other site 756272004023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272004024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272004025 putative substrate translocation pore; other site 756272004026 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 756272004027 GTP/Mg2+ binding site [chemical binding]; other site 756272004028 G4 box; other site 756272004029 G5 box; other site 756272004030 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 756272004031 G1 box; other site 756272004032 G1 box; other site 756272004033 GTP/Mg2+ binding site [chemical binding]; other site 756272004034 Switch I region; other site 756272004035 G2 box; other site 756272004036 G2 box; other site 756272004037 Switch I region; other site 756272004038 G3 box; other site 756272004039 G3 box; other site 756272004040 Switch II region; other site 756272004041 G4 box; other site 756272004042 G5 box; other site 756272004043 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 756272004044 Bacterial PH domain; Region: DUF304; pfam03703 756272004045 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 756272004046 Domain of unknown function DUF20; Region: UPF0118; pfam01594 756272004047 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 756272004048 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 756272004049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 756272004050 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272004051 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 756272004052 dimer interface [polypeptide binding]; other site 756272004053 active site 756272004054 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272004055 HEAT repeats; Region: HEAT_2; pfam13646 756272004056 Cytochrome c; Region: Cytochrom_C; cl11414 756272004057 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272004058 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 756272004059 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 756272004060 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 756272004061 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 756272004062 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272004063 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272004064 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272004065 substrate binding pocket [chemical binding]; other site 756272004066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272004067 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 756272004068 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 756272004069 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 756272004070 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 756272004071 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272004072 Sulfatase; Region: Sulfatase; pfam00884 756272004073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 756272004074 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 756272004075 putative active site [active] 756272004076 TRAM domain; Region: TRAM; cl01282 756272004077 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 756272004078 GIY-YIG motif/motif A; other site 756272004079 putative active site [active] 756272004080 putative metal binding site [ion binding]; other site 756272004081 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 756272004082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272004084 dimer interface [polypeptide binding]; other site 756272004085 phosphorylation site [posttranslational modification] 756272004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272004087 ATP binding site [chemical binding]; other site 756272004088 Mg2+ binding site [ion binding]; other site 756272004089 G-X-G motif; other site 756272004090 Response regulator receiver domain; Region: Response_reg; pfam00072 756272004091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272004092 active site 756272004093 phosphorylation site [posttranslational modification] 756272004094 intermolecular recognition site; other site 756272004095 dimerization interface [polypeptide binding]; other site 756272004096 circadian clock protein KaiC; Reviewed; Region: PRK09302 756272004097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272004098 Walker A motif; other site 756272004099 ATP binding site [chemical binding]; other site 756272004100 Walker B motif; other site 756272004101 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272004102 Walker A motif; other site 756272004103 ATP binding site [chemical binding]; other site 756272004104 Walker B motif; other site 756272004105 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 756272004106 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 756272004107 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 756272004108 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 756272004109 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 756272004110 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 756272004111 putative dimer interface [polypeptide binding]; other site 756272004112 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 756272004113 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 756272004114 putative dimer interface [polypeptide binding]; other site 756272004115 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 756272004116 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 756272004117 putative dimer interface [polypeptide binding]; other site 756272004118 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 756272004119 Ca2+ binding site [ion binding]; other site 756272004120 Predicted periplasmic protein [Function unknown]; Region: COG3904 756272004121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272004122 TPR motif; other site 756272004123 binding surface 756272004124 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 756272004125 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 756272004126 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 756272004127 putative active site [active] 756272004128 PhoH-like protein; Region: PhoH; pfam02562 756272004129 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272004130 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 756272004131 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 756272004132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272004133 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272004134 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 756272004135 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 756272004136 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 756272004137 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272004138 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272004139 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272004140 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272004141 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272004142 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272004143 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272004144 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 756272004145 apolar tunnel; other site 756272004146 heme binding site [chemical binding]; other site 756272004147 dimerization interface [polypeptide binding]; other site 756272004148 Uncharacterized conserved protein [Function unknown]; Region: COG0397 756272004149 hypothetical protein; Validated; Region: PRK00029 756272004150 Cupin domain; Region: Cupin_2; cl17218 756272004151 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272004152 putative catalytic site [active] 756272004153 putative metal binding site [ion binding]; other site 756272004154 putative phosphate binding site [ion binding]; other site 756272004155 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272004156 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272004157 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272004158 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272004159 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 756272004160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272004161 dimer interface [polypeptide binding]; other site 756272004162 conserved gate region; other site 756272004163 putative PBP binding loops; other site 756272004164 ABC-ATPase subunit interface; other site 756272004165 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 756272004166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 756272004167 helix-hairpin-helix signature motif; other site 756272004168 substrate binding pocket [chemical binding]; other site 756272004169 active site 756272004170 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 756272004171 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 756272004172 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 756272004173 PhnA protein; Region: PhnA; pfam03831 756272004174 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 756272004175 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 756272004176 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272004177 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272004179 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 756272004180 putative ligand binding site [chemical binding]; other site 756272004181 putative dimerization interface [polypeptide binding]; other site 756272004182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272004183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272004184 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004185 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004186 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004187 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004188 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272004189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272004190 active site 756272004191 phosphorylation site [posttranslational modification] 756272004192 intermolecular recognition site; other site 756272004193 dimerization interface [polypeptide binding]; other site 756272004194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272004195 Walker A motif; other site 756272004196 ATP binding site [chemical binding]; other site 756272004197 Walker B motif; other site 756272004198 arginine finger; other site 756272004199 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272004200 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 756272004201 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 756272004202 substrate binding site [chemical binding]; other site 756272004203 active site 756272004204 catalytic residues [active] 756272004205 heterodimer interface [polypeptide binding]; other site 756272004206 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 756272004207 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 756272004208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272004209 catalytic residue [active] 756272004210 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 756272004211 SOUL heme-binding protein; Region: SOUL; pfam04832 756272004212 Glucose dehydrogenase; Region: glucose_DH; cd08230 756272004213 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 756272004214 NADP binding site [chemical binding]; other site 756272004215 catalytic Zn binding site [ion binding]; other site 756272004216 structural Zn binding site [ion binding]; other site 756272004217 dimer interface [polypeptide binding]; other site 756272004218 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 756272004219 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 756272004220 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 756272004221 DNA binding site [nucleotide binding] 756272004222 active site 756272004223 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272004224 anti sigma factor interaction site; other site 756272004225 regulatory phosphorylation site [posttranslational modification]; other site 756272004226 methionine sulfoxide reductase A; Provisional; Region: PRK14054 756272004227 methionine sulfoxide reductase B; Provisional; Region: PRK00222 756272004228 SelR domain; Region: SelR; pfam01641 756272004229 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272004230 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 756272004231 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 756272004232 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 756272004233 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 756272004234 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 756272004235 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 756272004236 putative NAD(P) binding site [chemical binding]; other site 756272004237 catalytic Zn binding site [ion binding]; other site 756272004238 structural Zn binding site [ion binding]; other site 756272004239 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272004240 Sulfatase; Region: Sulfatase; pfam00884 756272004241 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272004242 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272004243 inhibitor site; inhibition site 756272004244 active site 756272004245 dimer interface [polypeptide binding]; other site 756272004246 catalytic residue [active] 756272004247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272004248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272004249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272004250 binding surface 756272004251 TPR motif; other site 756272004252 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 756272004253 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 756272004254 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 756272004255 Mechanosensitive ion channel; Region: MS_channel; pfam00924 756272004256 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 756272004257 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 756272004258 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 756272004259 active site 756272004260 substrate-binding site [chemical binding]; other site 756272004261 metal-binding site [ion binding] 756272004262 ATP binding site [chemical binding]; other site 756272004263 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 756272004264 Protein of unknown function DUF58; Region: DUF58; pfam01882 756272004265 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 756272004266 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272004267 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272004268 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 756272004269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 756272004270 nucleotide binding site [chemical binding]; other site 756272004271 Type III pantothenate kinase; Region: Pan_kinase; cl17198 756272004272 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272004273 Trp docking motif [polypeptide binding]; other site 756272004274 active site 756272004275 PQQ-like domain; Region: PQQ_2; pfam13360 756272004276 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 756272004277 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 756272004278 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 756272004279 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 756272004280 P loop; other site 756272004281 GTP binding site [chemical binding]; other site 756272004282 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 756272004283 DEAD/DEAH box helicase; Region: DEAD; pfam00270 756272004284 DEAD_2; Region: DEAD_2; pfam06733 756272004285 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 756272004286 HEAT repeats; Region: HEAT_2; pfam13646 756272004287 HEAT repeats; Region: HEAT_2; pfam13646 756272004288 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 756272004289 protein binding surface [polypeptide binding]; other site 756272004290 HEAT repeats; Region: HEAT_2; pfam13646 756272004291 HEAT repeats; Region: HEAT_2; pfam13646 756272004292 HEAT repeats; Region: HEAT_2; pfam13646 756272004293 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 756272004294 HEAT repeats; Region: HEAT_2; pfam13646 756272004295 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272004296 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272004297 structural tetrad; other site 756272004298 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272004299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272004300 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272004301 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272004302 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272004303 DDE superfamily endonuclease; Region: DDE_3; pfam13358 756272004304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 756272004305 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272004306 TPR repeat; Region: TPR_11; pfam13414 756272004307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272004308 TPR motif; other site 756272004309 binding surface 756272004310 TPR repeat; Region: TPR_11; pfam13414 756272004311 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272004312 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272004313 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004314 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 756272004315 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 756272004316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 756272004317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 756272004318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 756272004319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 756272004320 Reovirus RNA-dependent RNA polymerase lambda 3; Region: RdRP_5; pfam07925 756272004321 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 756272004322 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 756272004323 active site 756272004324 Zn binding site [ion binding]; other site 756272004325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272004326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272004327 active site 756272004328 ATP binding site [chemical binding]; other site 756272004329 substrate binding site [chemical binding]; other site 756272004330 activation loop (A-loop); other site 756272004331 aconitate hydratase; Validated; Region: PRK09277 756272004332 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 756272004333 substrate binding site [chemical binding]; other site 756272004334 ligand binding site [chemical binding]; other site 756272004335 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 756272004336 substrate binding site [chemical binding]; other site 756272004337 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272004338 protein binding site [polypeptide binding]; other site 756272004339 PilZ domain; Region: PilZ; pfam07238 756272004340 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 756272004341 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 756272004342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 756272004343 RNA binding surface [nucleotide binding]; other site 756272004344 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 756272004345 active site 756272004346 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 756272004347 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 756272004348 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 756272004349 ligand binding site [chemical binding]; other site 756272004350 NAD binding site [chemical binding]; other site 756272004351 catalytic site [active] 756272004352 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272004353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272004354 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 756272004355 periplasmic chaperone; Provisional; Region: PRK10780 756272004356 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 756272004357 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 756272004358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272004359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272004360 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272004361 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 756272004362 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 756272004363 heme binding site [chemical binding]; other site 756272004364 ferroxidase pore; other site 756272004365 ferroxidase diiron center [ion binding]; other site 756272004366 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 756272004367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272004368 ABC transporter; Region: ABC_tran_2; pfam12848 756272004369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272004370 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 756272004371 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 756272004372 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272004373 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 756272004374 putative NAD(P) binding site [chemical binding]; other site 756272004375 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 756272004376 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 756272004377 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 756272004378 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272004379 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 756272004380 active site 756272004381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 756272004382 Pirin-related protein [General function prediction only]; Region: COG1741 756272004383 Pirin; Region: Pirin; pfam02678 756272004384 Predicted membrane protein [Function unknown]; Region: COG2259 756272004385 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 756272004386 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 756272004387 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 756272004388 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 756272004389 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 756272004390 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 756272004391 generic binding surface II; other site 756272004392 generic binding surface I; other site 756272004393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272004394 Zn2+ binding site [ion binding]; other site 756272004395 Mg2+ binding site [ion binding]; other site 756272004396 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 756272004397 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 756272004398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272004399 catalytic residue [active] 756272004400 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 756272004401 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 756272004402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272004403 tetramer interface [polypeptide binding]; other site 756272004404 catalytic residue [active] 756272004405 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 756272004406 lipoyl attachment site [posttranslational modification]; other site 756272004407 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 756272004408 Low molecular weight phosphatase family; Region: LMWPc; cd00115 756272004409 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 756272004410 active site 756272004411 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 756272004412 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 756272004413 active site 756272004414 PRC-barrel domain; Region: PRC; pfam05239 756272004415 Peptidase family M50; Region: Peptidase_M50; pfam02163 756272004416 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 756272004417 active site 756272004418 putative substrate binding region [chemical binding]; other site 756272004419 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 756272004420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272004421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272004422 homodimer interface [polypeptide binding]; other site 756272004423 catalytic residue [active] 756272004424 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 756272004425 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 756272004426 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 756272004427 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 756272004428 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 756272004429 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 756272004430 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 756272004431 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 756272004432 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 756272004433 DNA binding site [nucleotide binding] 756272004434 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 756272004435 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 756272004436 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 756272004437 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 756272004438 RPB11 interaction site [polypeptide binding]; other site 756272004439 RPB12 interaction site [polypeptide binding]; other site 756272004440 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 756272004441 RPB3 interaction site [polypeptide binding]; other site 756272004442 RPB1 interaction site [polypeptide binding]; other site 756272004443 RPB11 interaction site [polypeptide binding]; other site 756272004444 RPB10 interaction site [polypeptide binding]; other site 756272004445 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 756272004446 peripheral dimer interface [polypeptide binding]; other site 756272004447 core dimer interface [polypeptide binding]; other site 756272004448 L10 interface [polypeptide binding]; other site 756272004449 L11 interface [polypeptide binding]; other site 756272004450 putative EF-Tu interaction site [polypeptide binding]; other site 756272004451 putative EF-G interaction site [polypeptide binding]; other site 756272004452 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 756272004453 23S rRNA interface [nucleotide binding]; other site 756272004454 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 756272004455 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 756272004456 mRNA/rRNA interface [nucleotide binding]; other site 756272004457 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 756272004458 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 756272004459 23S rRNA interface [nucleotide binding]; other site 756272004460 L7/L12 interface [polypeptide binding]; other site 756272004461 putative thiostrepton binding site; other site 756272004462 L25 interface [polypeptide binding]; other site 756272004463 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 756272004464 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 756272004465 putative homodimer interface [polypeptide binding]; other site 756272004466 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 756272004467 heterodimer interface [polypeptide binding]; other site 756272004468 homodimer interface [polypeptide binding]; other site 756272004469 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 756272004470 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 756272004471 elongation factor Tu; Reviewed; Region: PRK00049 756272004472 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 756272004473 G1 box; other site 756272004474 GEF interaction site [polypeptide binding]; other site 756272004475 GTP/Mg2+ binding site [chemical binding]; other site 756272004476 Switch I region; other site 756272004477 G2 box; other site 756272004478 G3 box; other site 756272004479 Switch II region; other site 756272004480 G4 box; other site 756272004481 G5 box; other site 756272004482 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 756272004483 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 756272004484 Antibiotic Binding Site [chemical binding]; other site 756272004485 HEAT repeats; Region: HEAT_2; pfam13646 756272004486 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272004487 Trp docking motif [polypeptide binding]; other site 756272004488 active site 756272004489 PQQ-like domain; Region: PQQ_2; pfam13360 756272004490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272004491 Coenzyme A binding pocket [chemical binding]; other site 756272004492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 756272004493 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272004494 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272004495 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 756272004496 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 756272004497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272004498 catalytic residues [active] 756272004499 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 756272004500 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 756272004501 active site 756272004502 substrate binding site [chemical binding]; other site 756272004503 cosubstrate binding site; other site 756272004504 catalytic site [active] 756272004505 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 756272004506 Uncharacterized conserved protein [Function unknown]; Region: COG1262 756272004507 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272004508 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 756272004509 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 756272004510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272004511 S-adenosylmethionine binding site [chemical binding]; other site 756272004512 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 756272004513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272004514 S-adenosylmethionine binding site [chemical binding]; other site 756272004515 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 756272004516 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 756272004517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272004518 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 756272004519 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 756272004520 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 756272004521 HemN C-terminal domain; Region: HemN_C; pfam06969 756272004522 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272004523 Trp docking motif [polypeptide binding]; other site 756272004524 active site 756272004525 PQQ-like domain; Region: PQQ_2; pfam13360 756272004526 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 756272004527 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 756272004528 active site 756272004529 metal binding site [ion binding]; metal-binding site 756272004530 PQQ-like domain; Region: PQQ_2; pfam13360 756272004531 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272004532 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272004533 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272004534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272004535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272004536 active site 756272004537 catalytic tetrad [active] 756272004538 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 756272004539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272004540 S-adenosylmethionine binding site [chemical binding]; other site 756272004541 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 756272004542 homotrimer interaction site [polypeptide binding]; other site 756272004543 putative active site [active] 756272004544 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 756272004545 active site 756272004546 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 756272004547 active site 756272004548 Ycf48-like protein; Provisional; Region: PRK13684 756272004549 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 756272004550 putative ligand binding site [chemical binding]; other site 756272004551 TPR repeat; Region: TPR_11; pfam13414 756272004552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272004553 binding surface 756272004554 TPR motif; other site 756272004555 TPR repeat; Region: TPR_11; pfam13414 756272004556 TPR repeat; Region: TPR_11; pfam13414 756272004557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272004558 binding surface 756272004559 TPR motif; other site 756272004560 seryl-tRNA synthetase; Provisional; Region: PRK05431 756272004561 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 756272004562 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 756272004563 dimer interface [polypeptide binding]; other site 756272004564 active site 756272004565 motif 1; other site 756272004566 motif 2; other site 756272004567 motif 3; other site 756272004568 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 756272004569 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272004570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272004571 catalytic residue [active] 756272004572 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 756272004573 RNA/DNA hybrid binding site [nucleotide binding]; other site 756272004574 active site 756272004575 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 756272004576 rRNA binding site [nucleotide binding]; other site 756272004577 predicted 30S ribosome binding site; other site 756272004578 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 756272004579 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 756272004580 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 756272004581 molybdopterin cofactor binding site; other site 756272004582 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 756272004583 molybdopterin cofactor binding site; other site 756272004584 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 756272004585 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 756272004586 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 756272004587 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 756272004588 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 756272004589 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 756272004590 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 756272004591 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 756272004592 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 756272004593 putative translocon binding site; other site 756272004594 protein-rRNA interface [nucleotide binding]; other site 756272004595 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 756272004596 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 756272004597 G-X-X-G motif; other site 756272004598 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 756272004599 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 756272004600 23S rRNA interface [nucleotide binding]; other site 756272004601 5S rRNA interface [nucleotide binding]; other site 756272004602 putative antibiotic binding site [chemical binding]; other site 756272004603 L25 interface [polypeptide binding]; other site 756272004604 L27 interface [polypeptide binding]; other site 756272004605 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 756272004606 23S rRNA interface [nucleotide binding]; other site 756272004607 putative translocon interaction site; other site 756272004608 signal recognition particle (SRP54) interaction site; other site 756272004609 L23 interface [polypeptide binding]; other site 756272004610 trigger factor interaction site; other site 756272004611 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 756272004612 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 756272004613 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 756272004614 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 756272004615 RNA binding site [nucleotide binding]; other site 756272004616 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 756272004617 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 756272004618 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 756272004619 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 756272004620 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 756272004621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 756272004622 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 756272004623 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 756272004624 5S rRNA interface [nucleotide binding]; other site 756272004625 23S rRNA interface [nucleotide binding]; other site 756272004626 L5 interface [polypeptide binding]; other site 756272004627 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 756272004628 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 756272004629 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 756272004630 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 756272004631 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 756272004632 SecY translocase; Region: SecY; pfam00344 756272004633 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 756272004634 active site 756272004635 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 756272004636 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 756272004637 30S ribosomal protein S13; Region: bact_S13; TIGR03631 756272004638 30S ribosomal protein S11; Validated; Region: PRK05309 756272004639 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 756272004640 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 756272004641 alphaNTD homodimer interface [polypeptide binding]; other site 756272004642 alphaNTD - beta interaction site [polypeptide binding]; other site 756272004643 alphaNTD - beta' interaction site [polypeptide binding]; other site 756272004644 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 756272004645 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 756272004646 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 756272004647 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 756272004648 active site 756272004649 SAM binding site [chemical binding]; other site 756272004650 homodimer interface [polypeptide binding]; other site 756272004651 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 756272004652 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 756272004653 active site 756272004654 YHYH protein; Region: YHYH; pfam14240 756272004655 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272004656 Sulfatase; Region: Sulfatase; pfam00884 756272004657 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272004658 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272004659 Metal-binding active site; metal-binding site 756272004660 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 756272004661 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272004662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272004663 Sulfatase; Region: Sulfatase; cl17466 756272004664 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272004665 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 756272004666 putative ADP-ribose binding site [chemical binding]; other site 756272004667 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 756272004668 Predicted membrane protein [Function unknown]; Region: COG2323 756272004669 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 756272004670 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272004671 catalytic residues [active] 756272004672 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 756272004673 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 756272004674 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 756272004675 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 756272004676 FAD binding pocket [chemical binding]; other site 756272004677 FAD binding motif [chemical binding]; other site 756272004678 phosphate binding motif [ion binding]; other site 756272004679 beta-alpha-beta structure motif; other site 756272004680 NAD binding pocket [chemical binding]; other site 756272004681 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 756272004682 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 756272004683 domain interfaces; other site 756272004684 active site 756272004685 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 756272004686 dimer interface [polypeptide binding]; other site 756272004687 putative tRNA-binding site [nucleotide binding]; other site 756272004688 HDOD domain; Region: HDOD; pfam08668 756272004689 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272004690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272004691 active site 756272004692 ATP binding site [chemical binding]; other site 756272004693 substrate binding site [chemical binding]; other site 756272004694 activation loop (A-loop); other site 756272004695 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 756272004696 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 756272004697 dimerization interface [polypeptide binding]; other site 756272004698 active site 756272004699 metal binding site [ion binding]; metal-binding site 756272004700 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 756272004701 dsRNA binding site [nucleotide binding]; other site 756272004702 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 756272004703 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272004704 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272004705 protein binding site [polypeptide binding]; other site 756272004706 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272004707 protein binding site [polypeptide binding]; other site 756272004708 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 756272004709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272004710 catalytic residues [active] 756272004711 universal stress protein UspE; Provisional; Region: PRK11175 756272004712 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 756272004713 Ligand Binding Site [chemical binding]; other site 756272004714 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 756272004715 Ligand Binding Site [chemical binding]; other site 756272004716 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272004717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272004718 active site 756272004719 phosphorylation site [posttranslational modification] 756272004720 intermolecular recognition site; other site 756272004721 dimerization interface [polypeptide binding]; other site 756272004722 AAA ATPase domain; Region: AAA_16; pfam13191 756272004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272004724 Walker A motif; other site 756272004725 ATP binding site [chemical binding]; other site 756272004726 Walker B motif; other site 756272004727 arginine finger; other site 756272004728 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 756272004729 DNA-binding interface [nucleotide binding]; DNA binding site 756272004730 acetylornithine deacetylase; Provisional; Region: PRK07522 756272004731 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 756272004732 metal binding site [ion binding]; metal-binding site 756272004733 putative dimer interface [polypeptide binding]; other site 756272004734 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 756272004735 Isochorismatase family; Region: Isochorismatase; pfam00857 756272004736 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 756272004737 catalytic triad [active] 756272004738 dimer interface [polypeptide binding]; other site 756272004739 conserved cis-peptide bond; other site 756272004740 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 756272004741 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 756272004742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272004743 FeS/SAM binding site; other site 756272004744 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272004745 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272004746 active site 756272004747 ATP binding site [chemical binding]; other site 756272004748 substrate binding site [chemical binding]; other site 756272004749 activation loop (A-loop); other site 756272004750 histidyl-tRNA synthetase; Region: hisS; TIGR00442 756272004751 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 756272004752 dimer interface [polypeptide binding]; other site 756272004753 motif 1; other site 756272004754 active site 756272004755 motif 2; other site 756272004756 motif 3; other site 756272004757 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 756272004758 anticodon binding site; other site 756272004759 Flagellin N-methylase; Region: FliB; cl00497 756272004760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272004761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272004762 Walker A/P-loop; other site 756272004763 ATP binding site [chemical binding]; other site 756272004764 Q-loop/lid; other site 756272004765 ABC transporter signature motif; other site 756272004766 Walker B; other site 756272004767 D-loop; other site 756272004768 H-loop/switch region; other site 756272004769 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 756272004770 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272004771 Outer membrane efflux protein; Region: OEP; pfam02321 756272004772 chaperone protein DnaJ; Provisional; Region: PRK14299 756272004773 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 756272004774 HSP70 interaction site [polypeptide binding]; other site 756272004775 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 756272004776 substrate binding site [polypeptide binding]; other site 756272004777 dimer interface [polypeptide binding]; other site 756272004778 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 756272004779 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 756272004780 aminoacyl-tRNA ligase; Region: PLN02563 756272004781 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 756272004782 HIGH motif; other site 756272004783 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 756272004784 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272004785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272004786 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272004787 active site 756272004788 KMSKS motif; other site 756272004789 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 756272004790 tRNA binding surface [nucleotide binding]; other site 756272004791 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 756272004792 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 756272004793 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 756272004794 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 756272004795 putative active site [active] 756272004796 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 756272004797 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 756272004798 dimer interface [polypeptide binding]; other site 756272004799 putative anticodon binding site; other site 756272004800 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272004801 motif 1; other site 756272004802 dimer interface [polypeptide binding]; other site 756272004803 active site 756272004804 motif 2; other site 756272004805 motif 3; other site 756272004806 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 756272004807 FtsX-like permease family; Region: FtsX; pfam02687 756272004808 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272004809 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272004810 Walker A/P-loop; other site 756272004811 ATP binding site [chemical binding]; other site 756272004812 Q-loop/lid; other site 756272004813 ABC transporter signature motif; other site 756272004814 Walker B; other site 756272004815 D-loop; other site 756272004816 H-loop/switch region; other site 756272004817 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 756272004818 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 756272004819 homodimer interface [polypeptide binding]; other site 756272004820 substrate-cofactor binding pocket; other site 756272004821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272004822 catalytic residue [active] 756272004823 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 756272004824 oligomerization interface [polypeptide binding]; other site 756272004825 active site 756272004826 metal binding site [ion binding]; metal-binding site 756272004827 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 756272004828 metal binding site [ion binding]; metal-binding site 756272004829 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 756272004830 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 756272004831 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 756272004832 RNA binding surface [nucleotide binding]; other site 756272004833 Uncharacterized conserved protein [Function unknown]; Region: COG1262 756272004834 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272004835 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004836 Protein of unknown function, DUF606; Region: DUF606; pfam04657 756272004837 Predicted transcriptional regulator [Transcription]; Region: COG2378 756272004838 HTH domain; Region: HTH_11; pfam08279 756272004839 WYL domain; Region: WYL; pfam13280 756272004840 FOG: CBS domain [General function prediction only]; Region: COG0517 756272004841 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 756272004842 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 756272004843 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 756272004844 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 756272004845 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 756272004846 trimer interface I [polypeptide binding]; other site 756272004847 putative substrate binding pocket [chemical binding]; other site 756272004848 trimer interface II [polypeptide binding]; other site 756272004849 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 756272004850 HEAT repeats; Region: HEAT_2; pfam13646 756272004851 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 756272004852 AAA domain; Region: AAA_23; pfam13476 756272004853 Walker A/P-loop; other site 756272004854 ATP binding site [chemical binding]; other site 756272004855 Q-loop/lid; other site 756272004856 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 756272004857 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 756272004858 ABC transporter signature motif; other site 756272004859 Walker B; other site 756272004860 D-loop; other site 756272004861 H-loop/switch region; other site 756272004862 Transposase; Region: DEDD_Tnp_IS110; pfam01548 756272004863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 756272004864 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 756272004865 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 756272004866 Predicted integral membrane protein [Function unknown]; Region: COG5615 756272004867 arginine decarboxylase; Provisional; Region: PRK05354 756272004868 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 756272004869 dimer interface [polypeptide binding]; other site 756272004870 active site 756272004871 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 756272004872 catalytic residues [active] 756272004873 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 756272004874 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272004875 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272004876 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272004877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272004878 active site 756272004879 phosphorylation site [posttranslational modification] 756272004880 intermolecular recognition site; other site 756272004881 dimerization interface [polypeptide binding]; other site 756272004882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272004883 Walker A motif; other site 756272004884 ATP binding site [chemical binding]; other site 756272004885 Walker B motif; other site 756272004886 arginine finger; other site 756272004887 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 756272004888 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 756272004889 Hpt domain; Region: Hpt; pfam01627 756272004890 putative binding surface; other site 756272004891 active site 756272004892 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 756272004893 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 756272004894 NAD(P) binding site [chemical binding]; other site 756272004895 catalytic residues [active] 756272004896 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 756272004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272004898 FeS/SAM binding site; other site 756272004899 SpoVG; Region: SpoVG; pfam04026 756272004900 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 756272004901 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 756272004902 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272004903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272004904 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 756272004905 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 756272004906 TM-ABC transporter signature motif; other site 756272004907 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 756272004908 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 756272004909 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 756272004910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 756272004911 nucleotide binding site [chemical binding]; other site 756272004912 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 756272004913 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 756272004914 GAF domain; Region: GAF_3; pfam13492 756272004915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 756272004916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 756272004917 metal binding site [ion binding]; metal-binding site 756272004918 active site 756272004919 I-site; other site 756272004920 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272004921 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 756272004922 Ligand binding site; other site 756272004923 Putative Catalytic site; other site 756272004924 DXD motif; other site 756272004925 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272004926 Sulfatase; Region: Sulfatase; pfam00884 756272004927 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272004928 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272004929 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272004930 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 756272004931 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 756272004932 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272004933 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272004934 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272004935 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 756272004936 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 756272004937 GDP-binding site [chemical binding]; other site 756272004938 ACT binding site; other site 756272004939 IMP binding site; other site 756272004940 PQQ-like domain; Region: PQQ_2; pfam13360 756272004941 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272004942 PQQ-like domain; Region: PQQ_2; pfam13360 756272004943 active site 756272004944 PQQ-like domain; Region: PQQ_2; pfam13360 756272004945 PQQ-like domain; Region: PQQ_2; pfam13360 756272004946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272004947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272004948 PGAP1-like protein; Region: PGAP1; pfam07819 756272004949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272004950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272004951 ATP binding site [chemical binding]; other site 756272004952 Mg2+ binding site [ion binding]; other site 756272004953 G-X-G motif; other site 756272004954 short chain dehydrogenase; Provisional; Region: PRK06181 756272004955 classical (c) SDRs; Region: SDR_c; cd05233 756272004956 NAD(P) binding site [chemical binding]; other site 756272004957 active site 756272004958 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 756272004959 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272004960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272004961 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 756272004962 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 756272004963 NAD(P) binding site [chemical binding]; other site 756272004964 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272004965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272004966 S-adenosylmethionine binding site [chemical binding]; other site 756272004967 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 756272004968 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 756272004969 ligand binding site [chemical binding]; other site 756272004970 flexible hinge region; other site 756272004971 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 756272004972 putative switch regulator; other site 756272004973 non-specific DNA interactions [nucleotide binding]; other site 756272004974 DNA binding site [nucleotide binding] 756272004975 sequence specific DNA binding site [nucleotide binding]; other site 756272004976 putative cAMP binding site [chemical binding]; other site 756272004977 Putative zinc-finger; Region: zf-HC2; pfam13490 756272004978 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 756272004979 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 756272004980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272004981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272004982 active site 756272004983 ATP binding site [chemical binding]; other site 756272004984 substrate binding site [chemical binding]; other site 756272004985 activation loop (A-loop); other site 756272004986 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272004987 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 756272004988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272004989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272004990 DNA binding residues [nucleotide binding] 756272004991 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272004992 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272004993 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272004994 structural tetrad; other site 756272004995 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272004996 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272004997 structural tetrad; other site 756272004998 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272004999 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005000 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272005001 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 756272005002 Walker A motif; other site 756272005003 ATP binding site [chemical binding]; other site 756272005004 Walker B motif; other site 756272005005 arginine finger; other site 756272005006 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272005007 active site 756272005008 catalytic triad [active] 756272005009 oxyanion hole [active] 756272005010 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005011 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 756272005012 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272005013 HEAT repeats; Region: HEAT_2; pfam13646 756272005014 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272005015 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272005016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272005017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272005018 S-adenosylmethionine binding site [chemical binding]; other site 756272005019 hypothetical protein; Provisional; Region: PHA02880 756272005020 hypothetical protein; Provisional; Region: PRK00106 756272005021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272005022 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 756272005023 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 756272005024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 756272005025 Beta-Casp domain; Region: Beta-Casp; smart01027 756272005026 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 756272005027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272005028 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 756272005029 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 756272005030 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 756272005031 Cl- selectivity filter; other site 756272005032 Cl- binding residues [ion binding]; other site 756272005033 pore gating glutamate residue; other site 756272005034 dimer interface [polypeptide binding]; other site 756272005035 FOG: CBS domain [General function prediction only]; Region: COG0517 756272005036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 756272005037 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 756272005038 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272005039 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 756272005040 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272005041 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272005042 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 756272005043 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 756272005044 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 756272005045 active site 756272005046 Zn binding site [ion binding]; other site 756272005047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272005048 metal ion-dependent adhesion site (MIDAS); other site 756272005049 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272005050 metal ion-dependent adhesion site (MIDAS); other site 756272005051 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 756272005052 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 756272005053 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 756272005054 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 756272005055 dimer interface [polypeptide binding]; other site 756272005056 active site residues [active] 756272005057 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 756272005058 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 756272005059 ligand binding site; other site 756272005060 oligomer interface; other site 756272005061 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 756272005062 dimer interface [polypeptide binding]; other site 756272005063 N-terminal domain interface [polypeptide binding]; other site 756272005064 sulfate 1 binding site; other site 756272005065 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005066 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 756272005067 ACT domain-containing protein [General function prediction only]; Region: COG4747 756272005068 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 756272005069 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272005070 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 756272005071 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 756272005072 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 756272005073 Ligand binding site; other site 756272005074 Putative Catalytic site; other site 756272005075 DXD motif; other site 756272005076 Domain of unknown function (DUF955); Region: DUF955; pfam06114 756272005077 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 756272005078 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 756272005079 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272005080 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 756272005081 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 756272005082 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 756272005083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 756272005084 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 756272005085 DnaA box-binding interface [nucleotide binding]; other site 756272005086 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 756272005087 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 756272005088 active site 756272005089 FMN binding site [chemical binding]; other site 756272005090 substrate binding site [chemical binding]; other site 756272005091 putative catalytic residue [active] 756272005092 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 756272005093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272005094 NAD(P) binding site [chemical binding]; other site 756272005095 active site 756272005096 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 756272005097 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 756272005098 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 756272005099 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272005100 putative active site [active] 756272005101 putative metal binding site [ion binding]; other site 756272005102 Domain of unknown function (DUF367); Region: DUF367; pfam04034 756272005103 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 756272005104 chemotaxis protein CheA; Provisional; Region: PRK10547 756272005105 putative binding surface; other site 756272005106 active site 756272005107 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 756272005108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272005109 ATP binding site [chemical binding]; other site 756272005110 Mg2+ binding site [ion binding]; other site 756272005111 G-X-G motif; other site 756272005112 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 756272005113 CheW-like domain; Region: CheW; pfam01584 756272005114 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272005115 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 756272005116 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 756272005117 heme-binding site [chemical binding]; other site 756272005118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005119 PAS domain; Region: PAS_9; pfam13426 756272005120 putative active site [active] 756272005121 heme pocket [chemical binding]; other site 756272005122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 756272005123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 756272005124 dimer interface [polypeptide binding]; other site 756272005125 putative CheW interface [polypeptide binding]; other site 756272005126 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 756272005127 B3/4 domain; Region: B3_4; pfam03483 756272005128 tRNA synthetase B5 domain; Region: B5; smart00874 756272005129 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272005130 motif 1; other site 756272005131 dimer interface [polypeptide binding]; other site 756272005132 active site 756272005133 motif 2; other site 756272005134 motif 3; other site 756272005135 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 756272005136 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 756272005137 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 756272005138 active site 756272005139 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 756272005140 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 756272005141 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 756272005142 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 756272005143 homodimer interface [polypeptide binding]; other site 756272005144 NADP binding site [chemical binding]; other site 756272005145 substrate binding site [chemical binding]; other site 756272005146 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 756272005147 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 756272005148 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 756272005149 UbiA prenyltransferase family; Region: UbiA; pfam01040 756272005150 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 756272005151 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 756272005152 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 756272005153 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168 756272005154 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 756272005155 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 756272005156 Cytochrome c; Region: Cytochrom_C; pfam00034 756272005157 Cytochrome c; Region: Cytochrom_C; pfam00034 756272005158 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 756272005159 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 756272005160 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 756272005161 G1 box; other site 756272005162 GTP/Mg2+ binding site [chemical binding]; other site 756272005163 G2 box; other site 756272005164 Switch I region; other site 756272005165 G3 box; other site 756272005166 Switch II region; other site 756272005167 G4 box; other site 756272005168 G5 box; other site 756272005169 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 756272005170 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 756272005171 Acylphosphatase; Region: Acylphosphatase; pfam00708 756272005172 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 756272005173 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 756272005174 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 756272005175 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272005176 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 756272005177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272005178 metal ion-dependent adhesion site (MIDAS); other site 756272005179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005180 PAS fold; Region: PAS_3; pfam08447 756272005181 putative active site [active] 756272005182 heme pocket [chemical binding]; other site 756272005183 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 756272005184 dimer interface [polypeptide binding]; other site 756272005185 phosphorylation site [posttranslational modification] 756272005186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272005187 ATP binding site [chemical binding]; other site 756272005188 Mg2+ binding site [ion binding]; other site 756272005189 G-X-G motif; other site 756272005190 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 756272005191 classical (c) SDRs; Region: SDR_c; cd05233 756272005192 NAD(P) binding site [chemical binding]; other site 756272005193 active site 756272005194 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 756272005195 hydrophobic ligand binding site; other site 756272005196 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 756272005197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272005198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272005199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 756272005200 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272005201 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272005202 MAEBL; Provisional; Region: PTZ00121 756272005203 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 756272005204 Noggin; Region: Noggin; pfam05806 756272005205 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 756272005206 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 756272005207 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 756272005208 substrate binding pocket [chemical binding]; other site 756272005209 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 756272005210 B12 binding site [chemical binding]; other site 756272005211 cobalt ligand [ion binding]; other site 756272005212 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 756272005213 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 756272005214 FAD binding site [chemical binding]; other site 756272005215 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 756272005216 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 756272005217 homotetramer interface [polypeptide binding]; other site 756272005218 ligand binding site [chemical binding]; other site 756272005219 catalytic site [active] 756272005220 NAD binding site [chemical binding]; other site 756272005221 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 756272005222 GcpE protein; Region: GcpE; pfam04551 756272005223 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 756272005224 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272005225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272005226 NAD(P) binding site [chemical binding]; other site 756272005227 active site 756272005228 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 756272005229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 756272005230 homodimer interface [polypeptide binding]; other site 756272005231 metal binding site [ion binding]; metal-binding site 756272005232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 756272005233 homodimer interface [polypeptide binding]; other site 756272005234 active site 756272005235 putative chemical substrate binding site [chemical binding]; other site 756272005236 metal binding site [ion binding]; metal-binding site 756272005237 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272005238 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 756272005239 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 756272005240 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272005241 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272005242 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272005243 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 756272005244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272005245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272005246 FtsX-like permease family; Region: FtsX; pfam02687 756272005247 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272005248 FtsX-like permease family; Region: FtsX; pfam02687 756272005249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272005250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272005251 Walker A/P-loop; other site 756272005252 ATP binding site [chemical binding]; other site 756272005253 Q-loop/lid; other site 756272005254 ABC transporter signature motif; other site 756272005255 Walker B; other site 756272005256 D-loop; other site 756272005257 H-loop/switch region; other site 756272005258 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 756272005259 active site 756272005260 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 756272005261 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 756272005262 Na binding site [ion binding]; other site 756272005263 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 756272005264 active site 756272005265 dimer interface [polypeptide binding]; other site 756272005266 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 756272005267 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 756272005268 Zn binding site [ion binding]; other site 756272005269 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 756272005270 isocitrate dehydrogenase; Validated; Region: PRK06451 756272005271 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272005272 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 756272005273 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 756272005274 putative active site [active] 756272005275 catalytic site [active] 756272005276 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 756272005277 putative active site [active] 756272005278 catalytic site [active] 756272005279 Maf-like protein; Region: Maf; pfam02545 756272005280 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 756272005281 active site 756272005282 dimer interface [polypeptide binding]; other site 756272005283 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272005284 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272005285 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 756272005286 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272005287 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272005288 FtsX-like permease family; Region: FtsX; pfam02687 756272005289 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272005290 PQQ-like domain; Region: PQQ_2; pfam13360 756272005291 Trp docking motif [polypeptide binding]; other site 756272005292 active site 756272005293 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 756272005294 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 756272005295 NAD(P) binding site [chemical binding]; other site 756272005296 homodimer interface [polypeptide binding]; other site 756272005297 substrate binding site [chemical binding]; other site 756272005298 active site 756272005299 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 756272005300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272005301 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 756272005302 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272005303 Sulfatase; Region: Sulfatase; cl17466 756272005304 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272005305 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 756272005306 dimer interface [polypeptide binding]; other site 756272005307 active site 756272005308 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 756272005309 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 756272005310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 756272005311 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 756272005312 active site 756272005313 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 756272005314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272005315 S-adenosylmethionine binding site [chemical binding]; other site 756272005316 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 756272005317 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 756272005318 putative active site [active] 756272005319 putative NTP binding site [chemical binding]; other site 756272005320 putative nucleic acid binding site [nucleotide binding]; other site 756272005321 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 756272005322 active site 756272005323 ADP/pyrophosphate binding site [chemical binding]; other site 756272005324 dimerization interface [polypeptide binding]; other site 756272005325 allosteric effector site; other site 756272005326 fructose-1,6-bisphosphate binding site; other site 756272005327 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 756272005328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272005329 motif II; other site 756272005330 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 756272005331 active site 756272005332 catalytic triad [active] 756272005333 oxyanion hole [active] 756272005334 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 756272005335 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 756272005336 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 756272005337 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 756272005338 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005339 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272005340 acetolactate synthase; Region: PLN02470 756272005341 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 756272005342 PYR/PP interface [polypeptide binding]; other site 756272005343 dimer interface [polypeptide binding]; other site 756272005344 TPP binding site [chemical binding]; other site 756272005345 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 756272005346 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 756272005347 TPP-binding site [chemical binding]; other site 756272005348 dimer interface [polypeptide binding]; other site 756272005349 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272005350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272005351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272005352 putative substrate translocation pore; other site 756272005353 SurA N-terminal domain; Region: SurA_N_3; cl07813 756272005354 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 756272005355 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 756272005356 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272005357 phosphopeptide binding site; other site 756272005358 B-Box C-terminal domain; Region: BBC; smart00502 756272005359 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 756272005360 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 756272005361 putative NAD(P) binding site [chemical binding]; other site 756272005362 catalytic Zn binding site [ion binding]; other site 756272005363 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 756272005364 DNA polymerase III subunit beta; Validated; Region: PRK05643 756272005365 putative DNA binding surface [nucleotide binding]; other site 756272005366 dimer interface [polypeptide binding]; other site 756272005367 beta-clamp/clamp loader binding surface; other site 756272005368 beta-clamp/translesion DNA polymerase binding surface; other site 756272005369 Protein of unknown function (DUF721); Region: DUF721; pfam05258 756272005370 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 756272005371 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 756272005372 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 756272005373 anchoring element; other site 756272005374 dimer interface [polypeptide binding]; other site 756272005375 ATP binding site [chemical binding]; other site 756272005376 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 756272005377 active site 756272005378 metal binding site [ion binding]; metal-binding site 756272005379 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 756272005380 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 756272005381 putative FMN binding site [chemical binding]; other site 756272005382 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272005383 Protein export membrane protein; Region: SecD_SecF; cl14618 756272005384 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272005385 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272005386 thiamine monophosphate kinase; Provisional; Region: PRK05731 756272005387 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 756272005388 ATP binding site [chemical binding]; other site 756272005389 dimerization interface [polypeptide binding]; other site 756272005390 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272005391 Sulfatase; Region: Sulfatase; cl17466 756272005392 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 756272005393 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 756272005394 hinge; other site 756272005395 active site 756272005396 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 756272005397 trimer interface [polypeptide binding]; other site 756272005398 dimer interface [polypeptide binding]; other site 756272005399 putative active site [active] 756272005400 Global regulator protein family; Region: CsrA; pfam02599 756272005401 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 756272005402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272005403 FeS/SAM binding site; other site 756272005404 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 756272005405 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 756272005406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272005407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272005408 homodimer interface [polypeptide binding]; other site 756272005409 catalytic residue [active] 756272005410 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 756272005411 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 756272005412 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 756272005413 putative DNA binding site [nucleotide binding]; other site 756272005414 catalytic residue [active] 756272005415 putative H2TH interface [polypeptide binding]; other site 756272005416 putative catalytic residues [active] 756272005417 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 756272005418 primosome assembly protein PriA; Validated; Region: PRK05580 756272005419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272005420 ATP binding site [chemical binding]; other site 756272005421 putative Mg++ binding site [ion binding]; other site 756272005422 helicase superfamily c-terminal domain; Region: HELICc; smart00490 756272005423 nucleotide binding region [chemical binding]; other site 756272005424 ATP-binding site [chemical binding]; other site 756272005425 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272005426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272005427 DNA binding residues [nucleotide binding] 756272005428 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 756272005429 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 756272005430 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 756272005431 LexA repressor; Validated; Region: PRK00215 756272005432 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 756272005433 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 756272005434 Catalytic site [active] 756272005435 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 756272005436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272005437 dihydropteroate synthase-related protein; Region: TIGR00284 756272005438 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 756272005439 substrate binding pocket [chemical binding]; other site 756272005440 dimer interface [polypeptide binding]; other site 756272005441 inhibitor binding site; inhibition site 756272005442 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 756272005443 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 756272005444 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 756272005445 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 756272005446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005447 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272005448 putative active site [active] 756272005449 heme pocket [chemical binding]; other site 756272005450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005451 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272005452 putative active site [active] 756272005453 heme pocket [chemical binding]; other site 756272005454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005455 putative active site [active] 756272005456 heme pocket [chemical binding]; other site 756272005457 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272005458 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272005459 PAS domain S-box; Region: sensory_box; TIGR00229 756272005460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005461 putative active site [active] 756272005462 heme pocket [chemical binding]; other site 756272005463 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272005464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005465 putative active site [active] 756272005466 heme pocket [chemical binding]; other site 756272005467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272005468 putative active site [active] 756272005469 heme pocket [chemical binding]; other site 756272005470 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272005471 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272005472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272005473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272005474 dimer interface [polypeptide binding]; other site 756272005475 phosphorylation site [posttranslational modification] 756272005476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272005477 ATP binding site [chemical binding]; other site 756272005478 Mg2+ binding site [ion binding]; other site 756272005479 G-X-G motif; other site 756272005480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272005481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272005482 active site 756272005483 phosphorylation site [posttranslational modification] 756272005484 intermolecular recognition site; other site 756272005485 dimerization interface [polypeptide binding]; other site 756272005486 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272005487 classical (c) SDRs; Region: SDR_c; cd05233 756272005488 NAD(P) binding site [chemical binding]; other site 756272005489 active site 756272005490 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272005491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272005492 catalytic residue [active] 756272005493 Herpesvirus tegument protein, N-terminal conserved region; Region: Herpes_teg_N; pfam04843 756272005494 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 756272005495 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 756272005496 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 756272005497 inhibitor-cofactor binding pocket; inhibition site 756272005498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272005499 catalytic residue [active] 756272005500 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 756272005501 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 756272005502 P-loop; other site 756272005503 Magnesium ion binding site [ion binding]; other site 756272005504 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 756272005505 Magnesium ion binding site [ion binding]; other site 756272005506 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 756272005507 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 756272005508 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 756272005509 ATP binding site [chemical binding]; other site 756272005510 Walker A motif; other site 756272005511 hexamer interface [polypeptide binding]; other site 756272005512 Walker B motif; other site 756272005513 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 756272005514 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272005515 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 756272005516 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272005517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 756272005518 DNA-binding site [nucleotide binding]; DNA binding site 756272005519 RNA-binding motif; other site 756272005520 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 756272005521 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 756272005522 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 756272005523 Rhomboid family; Region: Rhomboid; pfam01694 756272005524 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 756272005525 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 756272005526 putative ligand binding site [chemical binding]; other site 756272005527 putative NAD binding site [chemical binding]; other site 756272005528 catalytic site [active] 756272005529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272005530 active site 756272005531 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 756272005532 active site 756272005533 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 756272005534 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 756272005535 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 756272005536 SmpB-tmRNA interface; other site 756272005537 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 756272005538 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 756272005539 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272005540 PQQ-like domain; Region: PQQ_2; pfam13360 756272005541 CHAD domain; Region: CHAD; pfam05235 756272005542 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 756272005543 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272005544 putative catalytic residues [active] 756272005545 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272005546 Sulfatase; Region: Sulfatase; pfam00884 756272005547 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272005548 Sulfatase; Region: Sulfatase; pfam00884 756272005549 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 756272005550 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 756272005551 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 756272005552 substrate binding site [chemical binding]; other site 756272005553 active site 756272005554 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 756272005555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272005556 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272005557 Walker A motif; other site 756272005558 ATP binding site [chemical binding]; other site 756272005559 Walker B motif; other site 756272005560 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 756272005561 dihydrodipicolinate synthase; Region: dapA; TIGR00674 756272005562 dimer interface [polypeptide binding]; other site 756272005563 active site 756272005564 catalytic residue [active] 756272005565 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 756272005566 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 756272005567 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 756272005568 Part of AAA domain; Region: AAA_19; pfam13245 756272005569 Family description; Region: UvrD_C_2; pfam13538 756272005570 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272005571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272005572 active site 756272005573 ATP binding site [chemical binding]; other site 756272005574 substrate binding site [chemical binding]; other site 756272005575 activation loop (A-loop); other site 756272005576 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 756272005577 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 756272005578 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 756272005579 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 756272005580 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 756272005581 substrate binding site [chemical binding]; other site 756272005582 hexamer interface [polypeptide binding]; other site 756272005583 metal binding site [ion binding]; metal-binding site 756272005584 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272005585 Trp docking motif [polypeptide binding]; other site 756272005586 active site 756272005587 PQQ-like domain; Region: PQQ_2; pfam13360 756272005588 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 756272005589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272005590 Walker A motif; other site 756272005591 ATP binding site [chemical binding]; other site 756272005592 Walker B motif; other site 756272005593 arginine finger; other site 756272005594 Peptidase family M41; Region: Peptidase_M41; pfam01434 756272005595 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 756272005596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272005597 active site 756272005598 phosphorylation site [posttranslational modification] 756272005599 intermolecular recognition site; other site 756272005600 dimerization interface [polypeptide binding]; other site 756272005601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 756272005602 DNA binding site [nucleotide binding] 756272005603 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 756272005604 PhoU domain; Region: PhoU; pfam01895 756272005605 PhoU domain; Region: PhoU; pfam01895 756272005606 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 756272005607 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 756272005608 Walker A/P-loop; other site 756272005609 ATP binding site [chemical binding]; other site 756272005610 Q-loop/lid; other site 756272005611 ABC transporter signature motif; other site 756272005612 Walker B; other site 756272005613 D-loop; other site 756272005614 H-loop/switch region; other site 756272005615 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 756272005616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272005617 dimer interface [polypeptide binding]; other site 756272005618 conserved gate region; other site 756272005619 putative PBP binding loops; other site 756272005620 ABC-ATPase subunit interface; other site 756272005621 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 756272005622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272005623 dimer interface [polypeptide binding]; other site 756272005624 conserved gate region; other site 756272005625 putative PBP binding loops; other site 756272005626 ABC-ATPase subunit interface; other site 756272005627 PBP superfamily domain; Region: PBP_like_2; cl17296 756272005628 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272005630 S-adenosylmethionine binding site [chemical binding]; other site 756272005631 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 756272005632 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 756272005633 RNA binding site [nucleotide binding]; other site 756272005634 active site 756272005635 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 756272005636 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 756272005637 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 756272005638 PilZ domain; Region: PilZ; pfam07238 756272005639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272005640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272005641 active site 756272005642 catalytic tetrad [active] 756272005643 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 756272005644 active site 756272005645 Zn binding site [ion binding]; other site 756272005646 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 756272005647 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272005648 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272005649 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272005650 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 756272005651 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 756272005652 HEAT repeats; Region: HEAT_2; pfam13646 756272005653 HEAT repeats; Region: HEAT_2; pfam13646 756272005654 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 756272005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272005656 Walker A motif; other site 756272005657 ATP binding site [chemical binding]; other site 756272005658 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 756272005659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 756272005660 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 756272005661 active site 756272005662 HslU subunit interaction site [polypeptide binding]; other site 756272005663 SlyX; Region: SlyX; pfam04102 756272005664 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272005665 Trp docking motif [polypeptide binding]; other site 756272005666 PQQ-like domain; Region: PQQ_2; pfam13360 756272005667 active site 756272005668 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 756272005669 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 756272005670 Cysteine-rich domain; Region: CCG; pfam02754 756272005671 Cysteine-rich domain; Region: CCG; pfam02754 756272005672 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 756272005673 Domain of unknown function DUF21; Region: DUF21; pfam01595 756272005674 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 756272005675 Transporter associated domain; Region: CorC_HlyC; smart01091 756272005676 Domain of unknown function DUF21; Region: DUF21; pfam01595 756272005677 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 756272005678 RDD family; Region: RDD; pfam06271 756272005679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272005680 TPR motif; other site 756272005681 binding surface 756272005682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272005683 binding surface 756272005684 TPR motif; other site 756272005685 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 756272005686 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 756272005687 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 756272005688 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 756272005689 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 756272005690 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 756272005691 FliG C-terminal domain; Region: FliG_C; pfam01706 756272005692 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 756272005693 Flagellar assembly protein FliH; Region: FliH; pfam02108 756272005694 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 756272005695 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 756272005696 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 756272005697 Walker A motif/ATP binding site; other site 756272005698 Walker B motif; other site 756272005699 MgtE intracellular N domain; Region: MgtE_N; cl15244 756272005700 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 756272005701 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 756272005702 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 756272005703 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 756272005704 Flagellar protein (FlbD); Region: FlbD; pfam06289 756272005705 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 756272005706 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 756272005707 flagellar motor protein MotB; Validated; Region: motB; PRK06667 756272005708 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 756272005709 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 756272005710 ligand binding site [chemical binding]; other site 756272005711 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 756272005712 flagellar motor switch protein FliN; Region: fliN; TIGR02480 756272005713 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 756272005714 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 756272005715 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 756272005716 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 756272005717 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 756272005718 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 756272005719 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 756272005720 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 756272005721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272005722 Zn2+ binding site [ion binding]; other site 756272005723 Mg2+ binding site [ion binding]; other site 756272005724 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 756272005725 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 756272005726 active site 756272005727 dimer interface [polypeptide binding]; other site 756272005728 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 756272005729 Ligand Binding Site [chemical binding]; other site 756272005730 Molecular Tunnel; other site 756272005731 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 756272005732 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 756272005733 NADP binding site [chemical binding]; other site 756272005734 active site 756272005735 putative substrate binding site [chemical binding]; other site 756272005736 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 756272005737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272005738 active site 756272005739 HIGH motif; other site 756272005740 nucleotide binding site [chemical binding]; other site 756272005741 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 756272005742 KMSKS motif; other site 756272005743 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 756272005744 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 756272005745 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 756272005746 HIGH motif; other site 756272005747 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 756272005748 active site 756272005749 KMSKS motif; other site 756272005750 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 756272005751 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 756272005752 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 756272005753 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 756272005754 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 756272005755 metal-dependent hydrolase; Provisional; Region: PRK00685 756272005756 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 756272005757 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272005758 Zn2+ binding site [ion binding]; other site 756272005759 Mg2+ binding site [ion binding]; other site 756272005760 PAS domain; Region: PAS_9; pfam13426 756272005761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 756272005762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 756272005763 metal binding site [ion binding]; metal-binding site 756272005764 active site 756272005765 I-site; other site 756272005766 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272005767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272005768 S-adenosylmethionine binding site [chemical binding]; other site 756272005769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272005770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272005771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272005772 dimerization interface [polypeptide binding]; other site 756272005773 putative DNA binding site [nucleotide binding]; other site 756272005774 putative Zn2+ binding site [ion binding]; other site 756272005775 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272005776 active site residue [active] 756272005777 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 756272005778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 756272005779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272005780 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272005781 active site residue [active] 756272005782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272005783 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 756272005784 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272005785 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272005786 active site residue [active] 756272005787 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 756272005788 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 756272005789 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 756272005790 DsrE/DsrF-like family; Region: DrsE; pfam02635 756272005791 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272005792 Sulfatase; Region: Sulfatase; pfam00884 756272005793 Protein of unknown function (DUF502); Region: DUF502; cl01107 756272005794 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 756272005795 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272005796 dimer interface [polypeptide binding]; other site 756272005797 active site 756272005798 acyl carrier protein; Provisional; Region: acpP; PRK00982 756272005799 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005800 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005801 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005802 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005803 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 756272005804 dimerization interface [polypeptide binding]; other site 756272005805 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 756272005806 intracellular protease, PfpI family; Region: PfpI; TIGR01382 756272005807 proposed catalytic triad [active] 756272005808 conserved cys residue [active] 756272005809 [acyl-carrier protein] S-malonyltransferase; Region: PLN02752 756272005810 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 756272005811 putative phosphate acyltransferase; Provisional; Region: PRK05331 756272005812 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 756272005813 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 756272005814 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 756272005815 active site 756272005816 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 756272005817 Kelch motif; Region: Kelch_1; pfam01344 756272005818 Kelch domain; Region: Kelch; smart00612 756272005819 Kelch domain; Region: Kelch; smart00612 756272005820 Kelch motif; Region: Kelch_1; pfam01344 756272005821 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005822 Hemin uptake protein hemP; Region: hemP; pfam10636 756272005823 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 756272005824 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 756272005825 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272005826 GAF domain; Region: GAF_3; pfam13492 756272005827 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272005828 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272005829 Response regulator receiver domain; Region: Response_reg; pfam00072 756272005830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272005831 active site 756272005832 phosphorylation site [posttranslational modification] 756272005833 intermolecular recognition site; other site 756272005834 dimerization interface [polypeptide binding]; other site 756272005835 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 756272005836 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 756272005837 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 756272005838 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 756272005839 putative catalytic cysteine [active] 756272005840 Flagellin N-methylase; Region: FliB; pfam03692 756272005841 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 756272005842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272005843 active site 756272005844 phosphorylation site [posttranslational modification] 756272005845 intermolecular recognition site; other site 756272005846 dimerization interface [polypeptide binding]; other site 756272005847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272005848 DNA binding residues [nucleotide binding] 756272005849 dimerization interface [polypeptide binding]; other site 756272005850 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 756272005851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272005852 ATP binding site [chemical binding]; other site 756272005853 Walker B motif; other site 756272005854 arginine finger; other site 756272005855 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 756272005856 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 756272005857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272005858 putative substrate translocation pore; other site 756272005859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 756272005860 putative acyl-acceptor binding pocket; other site 756272005861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 756272005862 acyl-activating enzyme (AAE) consensus motif; other site 756272005863 AMP binding site [chemical binding]; other site 756272005864 active site 756272005865 CoA binding site [chemical binding]; other site 756272005866 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272005867 inhibitor site; inhibition site 756272005868 active site 756272005869 dimer interface [polypeptide binding]; other site 756272005870 catalytic residue [active] 756272005871 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 756272005872 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 756272005873 Predicted amidohydrolase [General function prediction only]; Region: COG0388 756272005874 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 756272005875 putative active site [active] 756272005876 catalytic triad [active] 756272005877 putative dimer interface [polypeptide binding]; other site 756272005878 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 756272005879 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 756272005880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272005881 Walker A/P-loop; other site 756272005882 ATP binding site [chemical binding]; other site 756272005883 Q-loop/lid; other site 756272005884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272005885 ABC transporter signature motif; other site 756272005886 Walker B; other site 756272005887 D-loop; other site 756272005888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272005889 threonine synthase; Validated; Region: PRK06260 756272005890 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 756272005891 homodimer interface [polypeptide binding]; other site 756272005892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272005893 catalytic residue [active] 756272005894 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 756272005895 Uncharacterized conserved protein [Function unknown]; Region: COG3379 756272005896 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 756272005897 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 756272005898 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 756272005899 DinB superfamily; Region: DinB_2; pfam12867 756272005900 Tic20-like protein; Region: Tic20; pfam09685 756272005901 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 756272005902 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 756272005903 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272005904 phosphopeptide binding site; other site 756272005905 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 756272005906 cyclase homology domain; Region: CHD; cd07302 756272005907 nucleotidyl binding site; other site 756272005908 metal binding site [ion binding]; metal-binding site 756272005909 dimer interface [polypeptide binding]; other site 756272005910 DNA gyrase subunit A; Validated; Region: PRK05560 756272005911 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 756272005912 CAP-like domain; other site 756272005913 active site 756272005914 primary dimer interface [polypeptide binding]; other site 756272005915 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272005916 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272005917 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272005918 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272005919 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 756272005920 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 756272005921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272005922 putative ADP-binding pocket [chemical binding]; other site 756272005923 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 756272005924 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272005925 active site 756272005926 metal binding site [ion binding]; metal-binding site 756272005927 homotetramer interface [polypeptide binding]; other site 756272005928 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 756272005929 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 756272005930 putative active site pocket [active] 756272005931 metal binding site [ion binding]; metal-binding site 756272005932 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 756272005933 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 756272005934 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 756272005935 Walker A motif; other site 756272005936 ATP binding site [chemical binding]; other site 756272005937 Walker B motif; other site 756272005938 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 756272005939 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272005940 Walker A motif; other site 756272005941 ATP binding site [chemical binding]; other site 756272005942 Walker B motif; other site 756272005943 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 756272005944 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 756272005945 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 756272005946 Walker A motif; other site 756272005947 ATP binding site [chemical binding]; other site 756272005948 Walker B motif; other site 756272005949 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 756272005950 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272005951 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272005952 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 756272005953 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 756272005954 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 756272005955 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272005956 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 756272005957 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272005958 metal ion-dependent adhesion site (MIDAS); other site 756272005959 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 756272005960 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 756272005961 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272005962 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272005963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272005964 active site 756272005965 ATP binding site [chemical binding]; other site 756272005966 substrate binding site [chemical binding]; other site 756272005967 activation loop (A-loop); other site 756272005968 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 756272005969 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 756272005970 putative metal binding site [ion binding]; other site 756272005971 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 756272005972 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272005973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272005974 S-adenosylmethionine binding site [chemical binding]; other site 756272005975 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 756272005976 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 756272005977 Nitrogen regulatory protein P-II; Region: P-II; smart00938 756272005978 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 756272005979 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 756272005980 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 756272005981 motif 1; other site 756272005982 active site 756272005983 motif 2; other site 756272005984 motif 3; other site 756272005985 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 756272005986 DHHA1 domain; Region: DHHA1; pfam02272 756272005987 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272005988 Trp docking motif [polypeptide binding]; other site 756272005989 active site 756272005990 PQQ-like domain; Region: PQQ_2; pfam13360 756272005991 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 756272005992 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 756272005993 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 756272005994 dimer interface [polypeptide binding]; other site 756272005995 motif 1; other site 756272005996 active site 756272005997 motif 2; other site 756272005998 motif 3; other site 756272005999 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 756272006000 23S rRNA binding site [nucleotide binding]; other site 756272006001 L21 binding site [polypeptide binding]; other site 756272006002 L13 binding site [polypeptide binding]; other site 756272006003 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 756272006004 translation initiation factor IF-3; Region: infC; TIGR00168 756272006005 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 756272006006 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 756272006007 TPR repeat; Region: TPR_11; pfam13414 756272006008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006009 binding surface 756272006010 TPR motif; other site 756272006011 TPR repeat; Region: TPR_11; pfam13414 756272006012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006013 binding surface 756272006014 TPR motif; other site 756272006015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006016 binding surface 756272006017 TPR motif; other site 756272006018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272006019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006020 binding surface 756272006021 TPR motif; other site 756272006022 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272006023 YacP-like NYN domain; Region: NYN_YacP; cl01491 756272006024 Predicted amidohydrolase [General function prediction only]; Region: COG0388 756272006025 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 756272006026 active site 756272006027 catalytic triad [active] 756272006028 dimer interface [polypeptide binding]; other site 756272006029 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 756272006030 Permease; Region: Permease; pfam02405 756272006031 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 756272006032 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 756272006033 Walker A/P-loop; other site 756272006034 ATP binding site [chemical binding]; other site 756272006035 Q-loop/lid; other site 756272006036 ABC transporter signature motif; other site 756272006037 Walker B; other site 756272006038 D-loop; other site 756272006039 H-loop/switch region; other site 756272006040 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 756272006041 mce related protein; Region: MCE; pfam02470 756272006042 Haem-binding domain; Region: Haem_bd; pfam14376 756272006043 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272006044 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272006045 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272006046 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272006047 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272006048 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272006049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272006050 TIGR01777 family protein; Region: yfcH 756272006051 NAD(P) binding site [chemical binding]; other site 756272006052 active site 756272006053 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 756272006054 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 756272006055 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 756272006056 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 756272006057 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 756272006058 FAD binding domain; Region: FAD_binding_4; pfam01565 756272006059 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 756272006060 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 756272006061 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 756272006062 Zn binding site [ion binding]; other site 756272006063 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272006064 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272006065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 756272006066 Cytochrome P450; Region: p450; cl12078 756272006067 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 756272006068 Protein phosphatase 2C; Region: PP2C; pfam00481 756272006069 active site 756272006070 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 756272006071 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 756272006072 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 756272006073 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 756272006074 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 756272006075 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 756272006076 heterotetramer interface [polypeptide binding]; other site 756272006077 active site pocket [active] 756272006078 cleavage site 756272006079 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 756272006080 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 756272006081 substrate binding pocket [chemical binding]; other site 756272006082 chain length determination region; other site 756272006083 substrate-Mg2+ binding site; other site 756272006084 catalytic residues [active] 756272006085 aspartate-rich region 1; other site 756272006086 active site lid residues [active] 756272006087 aspartate-rich region 2; other site 756272006088 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 756272006089 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 756272006090 TPP-binding site; other site 756272006091 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 756272006092 PYR/PP interface [polypeptide binding]; other site 756272006093 dimer interface [polypeptide binding]; other site 756272006094 TPP binding site [chemical binding]; other site 756272006095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 756272006096 Cupin-like domain; Region: Cupin_8; pfam13621 756272006097 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 756272006098 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 756272006099 Ligand Binding Site [chemical binding]; other site 756272006100 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272006101 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272006102 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 756272006103 hydroxyglutarate oxidase; Provisional; Region: PRK11728 756272006104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 756272006105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 756272006106 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 756272006107 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 756272006108 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 756272006109 Part of AAA domain; Region: AAA_19; pfam13245 756272006110 Family description; Region: UvrD_C_2; pfam13538 756272006111 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 756272006112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272006113 S-adenosylmethionine binding site [chemical binding]; other site 756272006114 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272006115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272006116 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272006117 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272006118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006119 active site 756272006120 phosphorylation site [posttranslational modification] 756272006121 intermolecular recognition site; other site 756272006122 dimerization interface [polypeptide binding]; other site 756272006123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006124 Walker A motif; other site 756272006125 ATP binding site [chemical binding]; other site 756272006126 Walker B motif; other site 756272006127 arginine finger; other site 756272006128 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272006129 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 756272006130 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 756272006131 protein binding site [polypeptide binding]; other site 756272006132 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 756272006133 Catalytic dyad [active] 756272006134 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 756272006135 Proline dehydrogenase; Region: Pro_dh; cl03282 756272006136 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 756272006137 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 756272006138 Glutamate binding site [chemical binding]; other site 756272006139 homodimer interface [polypeptide binding]; other site 756272006140 NAD binding site [chemical binding]; other site 756272006141 catalytic residues [active] 756272006142 Deoxyhypusine synthase; Region: DS; cl00826 756272006143 deoxyhypusine synthase; Region: dhys; TIGR00321 756272006144 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 756272006145 metal binding site 2 [ion binding]; metal-binding site 756272006146 putative DNA binding helix; other site 756272006147 metal binding site 1 [ion binding]; metal-binding site 756272006148 dimer interface [polypeptide binding]; other site 756272006149 structural Zn2+ binding site [ion binding]; other site 756272006150 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 756272006151 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 756272006152 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 756272006153 active site 756272006154 catalytic site [active] 756272006155 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 756272006156 Lumazine binding domain; Region: Lum_binding; pfam00677 756272006157 Lumazine binding domain; Region: Lum_binding; pfam00677 756272006158 AAA domain; Region: AAA_21; pfam13304 756272006159 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272006160 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272006161 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 756272006162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272006163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272006164 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 756272006165 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 756272006166 putative active site [active] 756272006167 Zn binding site [ion binding]; other site 756272006168 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 756272006169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272006170 TrkA-C domain; Region: TrkA_C; pfam02080 756272006171 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272006172 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 756272006173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272006174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 756272006175 dimerization interface [polypeptide binding]; other site 756272006176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272006177 dimer interface [polypeptide binding]; other site 756272006178 phosphorylation site [posttranslational modification] 756272006179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272006180 ATP binding site [chemical binding]; other site 756272006181 Mg2+ binding site [ion binding]; other site 756272006182 G-X-G motif; other site 756272006183 FOG: WD40-like repeat [Function unknown]; Region: COG1520 756272006184 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272006185 active site 756272006186 Trp docking motif [polypeptide binding]; other site 756272006187 PQQ-like domain; Region: PQQ_2; pfam13360 756272006188 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 756272006189 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 756272006190 PhoH-like protein; Region: PhoH; pfam02562 756272006191 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 756272006192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272006193 Zn2+ binding site [ion binding]; other site 756272006194 Mg2+ binding site [ion binding]; other site 756272006195 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 756272006196 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 756272006197 SPFH domain / Band 7 family; Region: Band_7; pfam01145 756272006198 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 756272006199 SPFH domain / Band 7 family; Region: Band_7; pfam01145 756272006200 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 756272006201 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 756272006202 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 756272006203 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272006204 active site 756272006205 ATP binding site [chemical binding]; other site 756272006206 substrate binding site [chemical binding]; other site 756272006207 activation loop (A-loop); other site 756272006208 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 756272006209 active site 756272006210 multimer interface [polypeptide binding]; other site 756272006211 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 756272006212 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 756272006213 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 756272006214 catalytic site [active] 756272006215 subunit interface [polypeptide binding]; other site 756272006216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272006217 dimerization interface [polypeptide binding]; other site 756272006218 putative DNA binding site [nucleotide binding]; other site 756272006219 putative Zn2+ binding site [ion binding]; other site 756272006220 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006221 Sulfatase; Region: Sulfatase; pfam00884 756272006222 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272006223 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 756272006224 Glucuronate isomerase; Region: UxaC; cl00829 756272006225 elongation factor G; Reviewed; Region: PRK00007 756272006226 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 756272006227 G1 box; other site 756272006228 putative GEF interaction site [polypeptide binding]; other site 756272006229 GTP/Mg2+ binding site [chemical binding]; other site 756272006230 Switch I region; other site 756272006231 G2 box; other site 756272006232 G3 box; other site 756272006233 Switch II region; other site 756272006234 G4 box; other site 756272006235 G5 box; other site 756272006236 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 756272006237 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 756272006238 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 756272006239 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 756272006240 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 756272006241 active site 756272006242 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 756272006243 C-terminal peptidase (prc); Region: prc; TIGR00225 756272006244 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 756272006245 protein binding site [polypeptide binding]; other site 756272006246 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 756272006247 Catalytic dyad [active] 756272006248 UGMP family protein; Validated; Region: PRK09604 756272006249 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 756272006250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272006251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272006252 dimer interface [polypeptide binding]; other site 756272006253 phosphorylation site [posttranslational modification] 756272006254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272006255 ATP binding site [chemical binding]; other site 756272006256 Mg2+ binding site [ion binding]; other site 756272006257 G-X-G motif; other site 756272006258 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272006259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006260 Response regulator receiver domain; Region: Response_reg; pfam00072 756272006261 active site 756272006262 phosphorylation site [posttranslational modification] 756272006263 intermolecular recognition site; other site 756272006264 dimerization interface [polypeptide binding]; other site 756272006265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 756272006266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 756272006267 nucleotide binding site [chemical binding]; other site 756272006268 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 756272006269 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 756272006270 polyphosphate kinase; Provisional; Region: PRK05443 756272006271 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 756272006272 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 756272006273 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 756272006274 putative domain interface [polypeptide binding]; other site 756272006275 putative active site [active] 756272006276 catalytic site [active] 756272006277 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 756272006278 putative domain interface [polypeptide binding]; other site 756272006279 putative active site [active] 756272006280 catalytic site [active] 756272006281 hypothetical protein; Provisional; Region: PRK13665 756272006282 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 756272006283 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 756272006284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272006285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272006286 DNA binding residues [nucleotide binding] 756272006287 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272006288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272006289 S-adenosylmethionine binding site [chemical binding]; other site 756272006290 potassium/proton antiporter; Reviewed; Region: PRK05326 756272006291 TrkA-C domain; Region: TrkA_C; pfam02080 756272006292 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006293 Sulfatase; Region: Sulfatase; pfam00884 756272006294 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 756272006295 recombinase A; Provisional; Region: recA; PRK09354 756272006296 hexamer interface [polypeptide binding]; other site 756272006297 Walker A motif; other site 756272006298 ATP binding site [chemical binding]; other site 756272006299 Walker B motif; other site 756272006300 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 756272006301 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272006302 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272006303 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 756272006304 dimer interface [polypeptide binding]; other site 756272006305 HEAT repeats; Region: HEAT_2; pfam13646 756272006306 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 756272006307 dinuclear metal binding motif [ion binding]; other site 756272006308 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 756272006309 Putative peptidase family; Region: Metallopep; pfam12044 756272006310 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 756272006311 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 756272006312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272006313 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272006314 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272006315 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272006316 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 756272006317 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272006318 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272006319 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272006320 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272006321 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 756272006322 TPR repeat; Region: TPR_11; pfam13414 756272006323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006324 binding surface 756272006325 TPR motif; other site 756272006326 TPR repeat; Region: TPR_11; pfam13414 756272006327 FOG: CBS domain [General function prediction only]; Region: COG0517 756272006328 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 756272006329 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 756272006330 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 756272006331 trmE is a tRNA modification GTPase; Region: trmE; cd04164 756272006332 G1 box; other site 756272006333 GTP/Mg2+ binding site [chemical binding]; other site 756272006334 Switch I region; other site 756272006335 G2 box; other site 756272006336 Switch II region; other site 756272006337 G3 box; other site 756272006338 G4 box; other site 756272006339 G5 box; other site 756272006340 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 756272006341 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272006342 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 756272006343 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 756272006344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272006345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272006346 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 756272006347 IMP binding site; other site 756272006348 dimer interface [polypeptide binding]; other site 756272006349 interdomain contacts; other site 756272006350 partial ornithine binding site; other site 756272006351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272006352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272006353 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 756272006354 L-aspartate oxidase; Provisional; Region: PRK06175 756272006355 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 756272006356 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 756272006357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272006358 classical (c) SDRs; Region: SDR_c; cd05233 756272006359 NAD(P) binding site [chemical binding]; other site 756272006360 active site 756272006361 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 756272006362 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 756272006363 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 756272006364 putative hydrophobic ligand binding site [chemical binding]; other site 756272006365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272006366 TIGR01777 family protein; Region: yfcH 756272006367 NAD(P) binding site [chemical binding]; other site 756272006368 active site 756272006369 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272006370 active site 756272006371 catalytic triad [active] 756272006372 oxyanion hole [active] 756272006373 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272006374 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272006375 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272006376 anti sigma factor interaction site; other site 756272006377 regulatory phosphorylation site [posttranslational modification]; other site 756272006378 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 756272006379 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 756272006380 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 756272006381 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 756272006382 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272006383 active site 756272006384 HIGH motif; other site 756272006385 nucleotide binding site [chemical binding]; other site 756272006386 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 756272006387 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 756272006388 active site 756272006389 KMSKS motif; other site 756272006390 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 756272006391 tRNA binding surface [nucleotide binding]; other site 756272006392 anticodon binding site; other site 756272006393 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 756272006394 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 756272006395 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 756272006396 active site 756272006397 catalytic residues [active] 756272006398 metal binding site [ion binding]; metal-binding site 756272006399 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 756272006400 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 756272006401 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 756272006402 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 756272006403 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 756272006404 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 756272006405 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 756272006406 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 756272006407 Walker A/P-loop; other site 756272006408 ATP binding site [chemical binding]; other site 756272006409 Q-loop/lid; other site 756272006410 ABC transporter signature motif; other site 756272006411 Walker B; other site 756272006412 D-loop; other site 756272006413 H-loop/switch region; other site 756272006414 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272006415 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 756272006416 Cytochrome c; Region: Cytochrom_C; pfam00034 756272006417 Cytochrome c; Region: Cytochrom_C; pfam00034 756272006418 dihydroorotase; Validated; Region: pyrC; PRK09357 756272006419 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 756272006420 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 756272006421 active site 756272006422 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 756272006423 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 756272006424 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 756272006425 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 756272006426 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 756272006427 DNA-binding site [nucleotide binding]; DNA binding site 756272006428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 756272006429 RNA binding surface [nucleotide binding]; other site 756272006430 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 756272006431 Fatty acid desaturase; Region: FA_desaturase; pfam00487 756272006432 putative di-iron ligands [ion binding]; other site 756272006433 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 756272006434 Serine hydrolase (FSH1); Region: FSH1; pfam03959 756272006435 Predicted esterase [General function prediction only]; Region: COG0400 756272006436 ABC1 family; Region: ABC1; cl17513 756272006437 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 756272006438 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 756272006439 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 756272006440 active site 756272006441 Riboflavin kinase; Region: Flavokinase; pfam01687 756272006442 CAAX protease self-immunity; Region: Abi; pfam02517 756272006443 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272006444 putative catalytic site [active] 756272006445 putative metal binding site [ion binding]; other site 756272006446 putative phosphate binding site [ion binding]; other site 756272006447 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 756272006448 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272006449 active site 756272006450 nucleotide binding site [chemical binding]; other site 756272006451 HIGH motif; other site 756272006452 KMSKS motif; other site 756272006453 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 756272006454 Domain of unknown function (DUF303); Region: DUF303; pfam03629 756272006455 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 756272006456 Zn binding site [ion binding]; other site 756272006457 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 756272006458 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 756272006459 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 756272006460 dimer interface [polypeptide binding]; other site 756272006461 decamer (pentamer of dimers) interface [polypeptide binding]; other site 756272006462 catalytic triad [active] 756272006463 peroxidatic and resolving cysteines [active] 756272006464 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 756272006465 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 756272006466 nucleophile elbow; other site 756272006467 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006468 Sulfatase; Region: Sulfatase; pfam00884 756272006469 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 756272006470 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 756272006471 FTR, proximal lobe; Region: FTR_C; pfam02741 756272006472 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 756272006473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006474 active site 756272006475 phosphorylation site [posttranslational modification] 756272006476 intermolecular recognition site; other site 756272006477 dimerization interface [polypeptide binding]; other site 756272006478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272006479 DNA binding residues [nucleotide binding] 756272006480 dimerization interface [polypeptide binding]; other site 756272006481 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 756272006482 homotrimer interaction site [polypeptide binding]; other site 756272006483 putative active site [active] 756272006484 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272006485 Trp docking motif [polypeptide binding]; other site 756272006486 active site 756272006487 PQQ-like domain; Region: PQQ_2; pfam13360 756272006488 ribonuclease R; Region: RNase_R; TIGR02063 756272006489 RNB domain; Region: RNB; pfam00773 756272006490 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 756272006491 RNA binding site [nucleotide binding]; other site 756272006492 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 756272006493 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 756272006494 generic binding surface II; other site 756272006495 generic binding surface I; other site 756272006496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272006497 Zn2+ binding site [ion binding]; other site 756272006498 Mg2+ binding site [ion binding]; other site 756272006499 prolyl-tRNA synthetase; Provisional; Region: PRK09194 756272006500 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272006501 motif 1; other site 756272006502 dimer interface [polypeptide binding]; other site 756272006503 active site 756272006504 motif 2; other site 756272006505 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 756272006506 putative deacylase active site [active] 756272006507 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272006508 active site 756272006509 motif 3; other site 756272006510 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 756272006511 anticodon binding site; other site 756272006512 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272006513 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272006514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272006515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272006516 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 756272006517 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 756272006518 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 756272006519 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272006520 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272006521 phosphopeptide binding site; other site 756272006522 GAF domain; Region: GAF_3; pfam13492 756272006523 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 756272006524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006525 Walker A motif; other site 756272006526 ATP binding site [chemical binding]; other site 756272006527 Walker B motif; other site 756272006528 arginine finger; other site 756272006529 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272006530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 756272006531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 756272006532 ligand binding site [chemical binding]; other site 756272006533 flexible hinge region; other site 756272006534 glutamate dehydrogenase; Region: PLN02477 756272006535 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 756272006536 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 756272006537 NAD(P) binding site [chemical binding]; other site 756272006538 TIGR03546 family protein; Region: TIGR03546 756272006539 TIGR03545 family protein; Region: TIGR03545 756272006540 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 756272006541 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 756272006542 NAD binding site [chemical binding]; other site 756272006543 substrate binding site [chemical binding]; other site 756272006544 homodimer interface [polypeptide binding]; other site 756272006545 active site 756272006546 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 756272006547 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 756272006548 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 756272006549 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 756272006550 peptide chain release factor 2; Validated; Region: prfB; PRK00578 756272006551 PCRF domain; Region: PCRF; pfam03462 756272006552 RF-1 domain; Region: RF-1; pfam00472 756272006553 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272006554 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272006555 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 756272006556 peptidase T-like protein; Region: PepT-like; TIGR01883 756272006557 metal binding site [ion binding]; metal-binding site 756272006558 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 756272006559 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 756272006560 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 756272006561 active site 756272006562 homodimer interface [polypeptide binding]; other site 756272006563 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 756272006564 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 756272006565 active site 756272006566 HIGH motif; other site 756272006567 dimer interface [polypeptide binding]; other site 756272006568 KMSKS motif; other site 756272006569 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272006570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272006571 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272006572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 756272006573 putative acyl-acceptor binding pocket; other site 756272006574 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 756272006575 iron-sulfur cluster [ion binding]; other site 756272006576 [2Fe-2S] cluster binding site [ion binding]; other site 756272006577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272006578 binding surface 756272006579 TPR motif; other site 756272006580 TPR repeat; Region: TPR_11; pfam13414 756272006581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006582 binding surface 756272006583 TPR motif; other site 756272006584 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272006585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272006586 binding surface 756272006587 TPR motif; other site 756272006588 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 756272006589 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 756272006590 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 756272006591 prephenate dehydrogenase; Validated; Region: PRK08507 756272006592 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 756272006593 Clp amino terminal domain; Region: Clp_N; pfam02861 756272006594 Clp amino terminal domain; Region: Clp_N; pfam02861 756272006595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006596 Walker A motif; other site 756272006597 ATP binding site [chemical binding]; other site 756272006598 Walker B motif; other site 756272006599 arginine finger; other site 756272006600 UvrB/uvrC motif; Region: UVR; pfam02151 756272006601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006602 Walker A motif; other site 756272006603 ATP binding site [chemical binding]; other site 756272006604 Walker B motif; other site 756272006605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 756272006606 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 756272006607 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 756272006608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006609 Walker A motif; other site 756272006610 ATP binding site [chemical binding]; other site 756272006611 Walker B motif; other site 756272006612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 756272006613 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 756272006614 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272006615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272006616 active site 756272006617 ATP binding site [chemical binding]; other site 756272006618 substrate binding site [chemical binding]; other site 756272006619 activation loop (A-loop); other site 756272006620 PQQ-like domain; Region: PQQ_2; pfam13360 756272006621 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272006622 Trp docking motif [polypeptide binding]; other site 756272006623 active site 756272006624 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272006625 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272006626 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272006627 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 756272006628 metal-binding site [ion binding] 756272006629 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272006630 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272006631 active site 756272006632 ATP binding site [chemical binding]; other site 756272006633 substrate binding site [chemical binding]; other site 756272006634 activation loop (A-loop); other site 756272006635 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 756272006636 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 756272006637 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272006638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272006639 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 756272006640 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 756272006641 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 756272006642 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 756272006643 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 756272006644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272006645 Walker A motif; other site 756272006646 ATP binding site [chemical binding]; other site 756272006647 Walker B motif; other site 756272006648 arginine finger; other site 756272006649 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272006650 Maf-like protein; Region: Maf; pfam02545 756272006651 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 756272006652 active site 756272006653 dimer interface [polypeptide binding]; other site 756272006654 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 756272006655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272006656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272006657 catalytic residue [active] 756272006658 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 756272006659 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 756272006660 putative acyl-acceptor binding pocket; other site 756272006661 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272006662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272006663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272006664 DNA binding residues [nucleotide binding] 756272006665 Type II/IV secretion system protein; Region: T2SE; pfam00437 756272006666 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272006667 Walker A motif; other site 756272006668 ATP binding site [chemical binding]; other site 756272006669 Walker B motif; other site 756272006670 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 756272006671 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272006672 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 756272006673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272006674 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272006675 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272006676 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272006677 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 756272006678 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 756272006679 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272006680 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 756272006681 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272006682 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272006683 phosphopeptide binding site; other site 756272006684 Protein kinase domain; Region: Pkinase; pfam00069 756272006685 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272006686 active site 756272006687 ATP binding site [chemical binding]; other site 756272006688 substrate binding site [chemical binding]; other site 756272006689 activation loop (A-loop); other site 756272006690 KaiC; Region: KaiC; pfam06745 756272006691 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272006692 Walker A motif; other site 756272006693 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 756272006694 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 756272006695 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 756272006696 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 756272006697 catalytic motif [active] 756272006698 Zn binding site [ion binding]; other site 756272006699 RibD C-terminal domain; Region: RibD_C; cl17279 756272006700 SEC-C motif; Region: SEC-C; pfam02810 756272006701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272006702 Walker A/P-loop; other site 756272006703 ATP binding site [chemical binding]; other site 756272006704 Q-loop/lid; other site 756272006705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272006706 ABC transporter signature motif; other site 756272006707 Walker B; other site 756272006708 D-loop; other site 756272006709 H-loop/switch region; other site 756272006710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272006711 Walker A/P-loop; other site 756272006712 ATP binding site [chemical binding]; other site 756272006713 Q-loop/lid; other site 756272006714 ABC transporter signature motif; other site 756272006715 Walker B; other site 756272006716 D-loop; other site 756272006717 H-loop/switch region; other site 756272006718 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 756272006719 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 756272006720 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 756272006721 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 756272006722 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 756272006723 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 756272006724 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272006725 active site 756272006726 metal binding site [ion binding]; metal-binding site 756272006727 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 756272006728 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 756272006729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272006730 S-adenosylmethionine binding site [chemical binding]; other site 756272006731 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 756272006732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 756272006733 active site 756272006734 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 756272006735 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 756272006736 Na binding site [ion binding]; other site 756272006737 Protein of unknown function, DUF485; Region: DUF485; pfam04341 756272006738 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 756272006739 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272006740 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 756272006741 dimer interface [polypeptide binding]; other site 756272006742 active site 756272006743 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 756272006744 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 756272006745 active site 756272006746 dimer interface [polypeptide binding]; other site 756272006747 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 756272006748 Ligand Binding Site [chemical binding]; other site 756272006749 Molecular Tunnel; other site 756272006750 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272006751 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272006752 active site 756272006753 catalytic tetrad [active] 756272006754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 756272006755 catalytic core [active] 756272006756 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 756272006757 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 756272006758 active site 756272006759 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 756272006760 cytidylate kinase; Provisional; Region: cmk; PRK00023 756272006761 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 756272006762 CMP-binding site; other site 756272006763 The sites determining sugar specificity; other site 756272006764 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 756272006765 Sodium Bile acid symporter family; Region: SBF; cl17470 756272006766 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 756272006767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272006768 S-adenosylmethionine binding site [chemical binding]; other site 756272006769 aromatic acid decarboxylase; Validated; Region: PRK05920 756272006770 Flavoprotein; Region: Flavoprotein; pfam02441 756272006771 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272006772 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272006773 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 756272006774 Bifunctional nuclease; Region: DNase-RNase; pfam02577 756272006775 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 756272006776 Protein of unknown function (DUF493); Region: DUF493; pfam04359 756272006777 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 756272006778 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 756272006779 TPP-binding site [chemical binding]; other site 756272006780 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 756272006781 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 756272006782 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 756272006783 dimer interface [polypeptide binding]; other site 756272006784 PYR/PP interface [polypeptide binding]; other site 756272006785 TPP binding site [chemical binding]; other site 756272006786 substrate binding site [chemical binding]; other site 756272006787 Ion channel; Region: Ion_trans_2; pfam07885 756272006788 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 756272006789 TrkA-N domain; Region: TrkA_N; pfam02254 756272006790 TrkA-C domain; Region: TrkA_C; pfam02080 756272006791 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 756272006792 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 756272006793 CoA-ligase; Region: Ligase_CoA; pfam00549 756272006794 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006795 Sulfatase; Region: Sulfatase; pfam00884 756272006796 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 756272006797 CoA binding domain; Region: CoA_binding; smart00881 756272006798 CoA-ligase; Region: Ligase_CoA; pfam00549 756272006799 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 756272006800 distal heme binding site [chemical binding]; other site 756272006801 proximal heme binding site [chemical binding]; other site 756272006802 putative dimer interface [polypeptide binding]; other site 756272006803 putative Iron-sulfur protein interface [polypeptide binding]; other site 756272006804 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 756272006805 L-aspartate oxidase; Provisional; Region: PRK06175 756272006806 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 756272006807 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 756272006808 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 756272006809 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 756272006810 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 756272006811 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 756272006812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 756272006813 classical (c) SDRs; Region: SDR_c; cd05233 756272006814 NAD(P) binding site [chemical binding]; other site 756272006815 active site 756272006816 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272006817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272006818 active site 756272006819 ATP binding site [chemical binding]; other site 756272006820 substrate binding site [chemical binding]; other site 756272006821 activation loop (A-loop); other site 756272006822 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 756272006823 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 756272006824 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 756272006825 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 756272006826 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 756272006827 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272006828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272006829 catalytic residue [active] 756272006830 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272006831 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272006832 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272006833 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 756272006834 Colicin V production protein; Region: Colicin_V; pfam02674 756272006835 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 756272006836 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 756272006837 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 756272006838 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 756272006839 putative active site; other site 756272006840 catalytic triad [active] 756272006841 putative dimer interface [polypeptide binding]; other site 756272006842 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272006843 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272006844 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272006845 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272006846 anti sigma factor interaction site; other site 756272006847 regulatory phosphorylation site [posttranslational modification]; other site 756272006848 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 756272006849 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 756272006850 dimer interface [polypeptide binding]; other site 756272006851 active site 756272006852 glycine-pyridoxal phosphate binding site [chemical binding]; other site 756272006853 folate binding site [chemical binding]; other site 756272006854 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 756272006855 Dimer interface [polypeptide binding]; other site 756272006856 BRCT sequence motif; other site 756272006857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 756272006858 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 756272006859 DNA binding residues [nucleotide binding] 756272006860 TPR repeat; Region: TPR_11; pfam13414 756272006861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272006862 TPR motif; other site 756272006863 TPR repeat; Region: TPR_11; pfam13414 756272006864 binding surface 756272006865 TPR repeat; Region: TPR_11; pfam13414 756272006866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272006867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272006868 active site 756272006869 ATP binding site [chemical binding]; other site 756272006870 substrate binding site [chemical binding]; other site 756272006871 activation loop (A-loop); other site 756272006872 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006873 Sulfatase; Region: Sulfatase; pfam00884 756272006874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 756272006875 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 756272006876 substrate binding site [chemical binding]; other site 756272006877 oxyanion hole (OAH) forming residues; other site 756272006878 trimer interface [polypeptide binding]; other site 756272006879 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 756272006880 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 756272006881 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 756272006882 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 756272006883 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 756272006884 dimer interface [polypeptide binding]; other site 756272006885 active site 756272006886 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 756272006887 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 756272006888 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 756272006889 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 756272006890 putative active site [active] 756272006891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 756272006892 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 756272006893 metal binding triad; other site 756272006894 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 756272006895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 756272006896 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272006897 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 756272006898 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 756272006899 Nitrogen regulatory protein P-II; Region: P-II; smart00938 756272006900 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 756272006901 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272006902 Family of unknown function (DUF695); Region: DUF695; pfam05117 756272006903 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272006904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272006905 S-adenosylmethionine binding site [chemical binding]; other site 756272006906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 756272006907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 756272006908 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272006909 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272006910 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272006911 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272006912 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 756272006913 Peptidase S8 family domain in Tripeptidyl aminopeptidases_II; Region: Peptidases_S8_Tripeptidyl_Aminopeptidase_II; cd04857 756272006914 putative active site [active] 756272006915 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 756272006916 putative catalytic triad [active] 756272006917 Tripeptidyl peptidase II; Region: TPPII; pfam12580 756272006918 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 756272006919 active site 756272006920 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 756272006921 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 756272006922 Active Sites [active] 756272006923 ZIP Zinc transporter; Region: Zip; pfam02535 756272006924 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 756272006925 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 756272006926 homodecamer interface [polypeptide binding]; other site 756272006927 GTP cyclohydrolase I; Provisional; Region: PLN03044 756272006928 active site 756272006929 putative catalytic site residues [active] 756272006930 zinc binding site [ion binding]; other site 756272006931 GTP-CH-I/GFRP interaction surface; other site 756272006932 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 756272006933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272006934 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 756272006935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 756272006936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 756272006937 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 756272006938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272006939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272006940 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272006941 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272006942 Protein export membrane protein; Region: SecD_SecF; cl14618 756272006943 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 756272006944 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 756272006945 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 756272006946 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 756272006947 TrkA-N domain; Region: TrkA_N; pfam02254 756272006948 TrkA-C domain; Region: TrkA_C; pfam02080 756272006949 PAS fold; Region: PAS_4; pfam08448 756272006950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272006951 putative active site [active] 756272006952 heme pocket [chemical binding]; other site 756272006953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272006954 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272006955 putative active site [active] 756272006956 heme pocket [chemical binding]; other site 756272006957 PAS domain S-box; Region: sensory_box; TIGR00229 756272006958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272006959 putative active site [active] 756272006960 heme pocket [chemical binding]; other site 756272006961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272006962 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 756272006963 putative active site [active] 756272006964 heme pocket [chemical binding]; other site 756272006965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272006966 dimer interface [polypeptide binding]; other site 756272006967 phosphorylation site [posttranslational modification] 756272006968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272006969 ATP binding site [chemical binding]; other site 756272006970 Mg2+ binding site [ion binding]; other site 756272006971 G-X-G motif; other site 756272006972 Response regulator receiver domain; Region: Response_reg; pfam00072 756272006973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006974 active site 756272006975 phosphorylation site [posttranslational modification] 756272006976 intermolecular recognition site; other site 756272006977 dimerization interface [polypeptide binding]; other site 756272006978 Response regulator receiver domain; Region: Response_reg; pfam00072 756272006979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006980 active site 756272006981 phosphorylation site [posttranslational modification] 756272006982 intermolecular recognition site; other site 756272006983 dimerization interface [polypeptide binding]; other site 756272006984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272006985 dimer interface [polypeptide binding]; other site 756272006986 phosphorylation site [posttranslational modification] 756272006987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272006988 ATP binding site [chemical binding]; other site 756272006989 Mg2+ binding site [ion binding]; other site 756272006990 G-X-G motif; other site 756272006991 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272006992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272006993 active site 756272006994 phosphorylation site [posttranslational modification] 756272006995 intermolecular recognition site; other site 756272006996 dimerization interface [polypeptide binding]; other site 756272006997 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272006998 Sulfatase; Region: Sulfatase; pfam00884 756272006999 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 756272007000 malate dehydrogenase; Provisional; Region: PRK05442 756272007001 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 756272007002 NAD(P) binding site [chemical binding]; other site 756272007003 dimer interface [polypeptide binding]; other site 756272007004 malate binding site [chemical binding]; other site 756272007005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272007006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 756272007007 active site 756272007008 metal binding site [ion binding]; metal-binding site 756272007009 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 756272007010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272007011 Zn2+ binding site [ion binding]; other site 756272007012 Mg2+ binding site [ion binding]; other site 756272007013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272007014 ATP binding site [chemical binding]; other site 756272007015 putative Mg++ binding site [ion binding]; other site 756272007016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272007017 nucleotide binding region [chemical binding]; other site 756272007018 ATP-binding site [chemical binding]; other site 756272007019 CTP synthetase; Validated; Region: pyrG; PRK05380 756272007020 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 756272007021 Catalytic site [active] 756272007022 active site 756272007023 UTP binding site [chemical binding]; other site 756272007024 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 756272007025 active site 756272007026 putative oxyanion hole; other site 756272007027 catalytic triad [active] 756272007028 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 756272007029 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 756272007030 Ligand binding site; other site 756272007031 oligomer interface; other site 756272007032 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272007033 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 756272007034 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 756272007035 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 756272007036 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 756272007037 aromatic arch; other site 756272007038 DCoH dimer interaction site [polypeptide binding]; other site 756272007039 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 756272007040 DCoH tetramer interaction site [polypeptide binding]; other site 756272007041 substrate binding site [chemical binding]; other site 756272007042 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272007043 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272007044 phosphopeptide binding site; other site 756272007045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272007046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272007047 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 756272007048 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272007049 dimer interface [polypeptide binding]; other site 756272007050 active site 756272007051 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 756272007052 acyl carrier protein; Provisional; Region: acpP; PRK00982 756272007053 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 756272007054 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 756272007055 NAD(P) binding site [chemical binding]; other site 756272007056 homotetramer interface [polypeptide binding]; other site 756272007057 homodimer interface [polypeptide binding]; other site 756272007058 active site 756272007059 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 756272007060 Uncharacterized conserved protein [Function unknown]; Region: COG1262 756272007061 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272007062 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 756272007063 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 756272007064 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 756272007065 dimerization interface [polypeptide binding]; other site 756272007066 putative ATP binding site [chemical binding]; other site 756272007067 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 756272007068 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 756272007069 tandem repeat interface [polypeptide binding]; other site 756272007070 oligomer interface [polypeptide binding]; other site 756272007071 active site residues [active] 756272007072 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272007073 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272007074 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272007075 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 756272007076 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272007077 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 756272007078 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 756272007079 Sulfate transporter family; Region: Sulfate_transp; pfam00916 756272007080 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 756272007081 active site clefts [active] 756272007082 zinc binding site [ion binding]; other site 756272007083 dimer interface [polypeptide binding]; other site 756272007084 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272007085 active site 756272007086 Int/Topo IB signature motif; other site 756272007087 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272007088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272007089 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272007090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 756272007091 dimerization interface [polypeptide binding]; other site 756272007092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007093 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 756272007094 putative active site [active] 756272007095 heme pocket [chemical binding]; other site 756272007096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007097 dimer interface [polypeptide binding]; other site 756272007098 phosphorylation site [posttranslational modification] 756272007099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007100 ATP binding site [chemical binding]; other site 756272007101 Mg2+ binding site [ion binding]; other site 756272007102 G-X-G motif; other site 756272007103 Response regulator receiver domain; Region: Response_reg; pfam00072 756272007104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007105 active site 756272007106 phosphorylation site [posttranslational modification] 756272007107 intermolecular recognition site; other site 756272007108 dimerization interface [polypeptide binding]; other site 756272007109 FecR protein; Region: FecR; pfam04773 756272007110 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272007111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007112 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007113 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007114 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007115 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 756272007116 putative catalytic site [active] 756272007117 putative metal binding site [ion binding]; other site 756272007118 putative phosphate binding site [ion binding]; other site 756272007119 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 756272007120 catalytic nucleophile [active] 756272007121 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272007122 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272007123 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272007124 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272007125 Sulfatase; Region: Sulfatase; cl17466 756272007126 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007127 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007128 Sulfatase; Region: Sulfatase; pfam00884 756272007129 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272007130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272007131 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272007132 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007133 Sulfatase; Region: Sulfatase; cl17466 756272007134 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007135 Sulfatase; Region: Sulfatase; pfam00884 756272007136 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007137 Sulfatase; Region: Sulfatase; pfam00884 756272007138 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007139 Sulfatase; Region: Sulfatase; pfam00884 756272007140 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007141 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272007142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272007144 DNA binding residues [nucleotide binding] 756272007145 FecR protein; Region: FecR; pfam04773 756272007146 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272007147 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272007148 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 756272007149 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 756272007150 Domain of unknown function (DUF303); Region: DUF303; pfam03629 756272007151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272007152 NADH(P)-binding; Region: NAD_binding_10; pfam13460 756272007153 NAD(P) binding site [chemical binding]; other site 756272007154 active site 756272007155 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007156 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007157 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007158 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007159 FecR protein; Region: FecR; pfam04773 756272007160 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272007161 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272007162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007163 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 756272007164 DNA binding residues [nucleotide binding] 756272007165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272007166 dimerization interface [polypeptide binding]; other site 756272007167 putative DNA binding site [nucleotide binding]; other site 756272007168 putative Zn2+ binding site [ion binding]; other site 756272007169 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 756272007170 arsenical-resistance protein; Region: acr3; TIGR00832 756272007171 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 756272007172 Low molecular weight phosphatase family; Region: LMWPc; cd00115 756272007173 active site 756272007174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272007175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272007176 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 756272007177 active site 756272007178 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 756272007180 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 756272007181 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272007182 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272007183 Cytochrome c; Region: Cytochrom_C; pfam00034 756272007184 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007185 Sulfatase; Region: Sulfatase; cl17466 756272007186 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007187 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007188 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007189 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272007190 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007191 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272007192 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272007193 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272007194 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272007195 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272007196 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 756272007197 DNA Polymerase Y-family; Region: PolY_like; cd03468 756272007198 active site 756272007199 DNA binding site [nucleotide binding] 756272007200 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 756272007201 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 756272007202 putative active site [active] 756272007203 putative PHP Thumb interface [polypeptide binding]; other site 756272007204 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 756272007205 generic binding surface I; other site 756272007206 generic binding surface II; other site 756272007207 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272007208 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272007209 active site 756272007210 metal binding site [ion binding]; metal-binding site 756272007211 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 756272007212 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 756272007213 V-type ATP synthase subunit A; Provisional; Region: PRK04192 756272007214 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 756272007215 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 756272007216 Walker A motif/ATP binding site; other site 756272007217 Walker B motif; other site 756272007218 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 756272007219 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 756272007220 V-type ATP synthase subunit E; Provisional; Region: PRK01558 756272007221 V-type ATP synthase subunit K; Provisional; Region: PRK09621 756272007222 V-type ATP synthase subunit I; Validated; Region: PRK05771 756272007223 ATP synthase subunit D; Region: ATP-synt_D; cl00613 756272007224 V-type ATP synthase subunit B; Provisional; Region: PRK02118 756272007225 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 756272007226 Walker A motif homologous position; other site 756272007227 Walker B motif; other site 756272007228 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272007229 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272007230 active site 756272007231 ATP binding site [chemical binding]; other site 756272007232 substrate binding site [chemical binding]; other site 756272007233 activation loop (A-loop); other site 756272007234 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 756272007235 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 756272007236 putative ligand binding site [chemical binding]; other site 756272007237 Right handed beta helix region; Region: Beta_helix; pfam13229 756272007238 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 756272007239 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 756272007240 Uncharacterized conserved protein [Function unknown]; Region: COG5276 756272007241 LVIVD repeat; Region: LVIVD; pfam08309 756272007242 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 756272007243 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 756272007244 Soluble P-type ATPase [General function prediction only]; Region: COG4087 756272007245 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272007246 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272007247 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272007248 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272007249 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272007250 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272007251 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 756272007252 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 756272007253 active site 756272007254 catalytic residues [active] 756272007255 probable purple acid phosphatase; Region: PLN02533 756272007256 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 756272007257 active site 756272007258 metal binding site [ion binding]; metal-binding site 756272007259 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 756272007260 Na binding site [ion binding]; other site 756272007261 putative glycosylation site [posttranslational modification]; other site 756272007262 putative glycosylation site [posttranslational modification]; other site 756272007263 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 756272007264 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 756272007265 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 756272007266 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 756272007267 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 756272007268 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 756272007269 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 756272007270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 756272007271 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 756272007272 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 756272007273 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 756272007274 TspO/MBR family; Region: TspO_MBR; pfam03073 756272007275 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 756272007276 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272007277 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 756272007278 active site 756272007279 catalytic triad [active] 756272007280 oxyanion hole [active] 756272007281 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 756272007282 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 756272007283 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 756272007284 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 756272007285 metal-binding site [ion binding] 756272007286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 756272007287 Soluble P-type ATPase [General function prediction only]; Region: COG4087 756272007288 Family description; Region: DsbD_2; pfam13386 756272007289 FixH; Region: FixH; pfam05751 756272007290 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 756272007291 4Fe-4S binding domain; Region: Fer4_5; pfam12801 756272007292 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 756272007293 Cytochrome c; Region: Cytochrom_C; cl11414 756272007294 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 756272007295 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 756272007296 Low-spin heme binding site [chemical binding]; other site 756272007297 Putative water exit pathway; other site 756272007298 Binuclear center (active site) [active] 756272007299 Putative proton exit pathway; other site 756272007300 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 756272007301 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272007302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007303 active site 756272007304 phosphorylation site [posttranslational modification] 756272007305 intermolecular recognition site; other site 756272007306 dimerization interface [polypeptide binding]; other site 756272007307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272007308 Walker A motif; other site 756272007309 ATP binding site [chemical binding]; other site 756272007310 Walker B motif; other site 756272007311 arginine finger; other site 756272007312 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272007313 Response regulator receiver domain; Region: Response_reg; pfam00072 756272007314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007315 active site 756272007316 phosphorylation site [posttranslational modification] 756272007317 intermolecular recognition site; other site 756272007318 dimerization interface [polypeptide binding]; other site 756272007319 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 756272007320 heme-binding site [chemical binding]; other site 756272007321 GAF domain; Region: GAF_3; pfam13492 756272007322 PAS domain; Region: PAS_9; pfam13426 756272007323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007324 putative active site [active] 756272007325 heme pocket [chemical binding]; other site 756272007326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007328 dimer interface [polypeptide binding]; other site 756272007329 phosphorylation site [posttranslational modification] 756272007330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007331 ATP binding site [chemical binding]; other site 756272007332 Mg2+ binding site [ion binding]; other site 756272007333 G-X-G motif; other site 756272007334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272007335 active site 756272007336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 756272007337 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 756272007338 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 756272007339 Ligand Binding Site [chemical binding]; other site 756272007340 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 756272007341 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007342 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 756272007343 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272007344 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 756272007345 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007346 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 756272007347 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 756272007348 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007349 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007350 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007351 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272007352 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272007353 structural tetrad; other site 756272007354 PAS domain; Region: PAS_9; pfam13426 756272007355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007356 putative active site [active] 756272007357 heme pocket [chemical binding]; other site 756272007358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007360 dimer interface [polypeptide binding]; other site 756272007361 phosphorylation site [posttranslational modification] 756272007362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007363 ATP binding site [chemical binding]; other site 756272007364 Mg2+ binding site [ion binding]; other site 756272007365 G-X-G motif; other site 756272007366 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272007367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007368 active site 756272007369 phosphorylation site [posttranslational modification] 756272007370 intermolecular recognition site; other site 756272007371 dimerization interface [polypeptide binding]; other site 756272007372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272007373 Walker A motif; other site 756272007374 ATP binding site [chemical binding]; other site 756272007375 Walker B motif; other site 756272007376 arginine finger; other site 756272007377 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 756272007378 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 756272007379 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007380 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007381 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007382 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007383 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272007384 Transcriptional regulator [Transcription]; Region: IclR; COG1414 756272007385 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 756272007386 Bacterial transcriptional regulator; Region: IclR; pfam01614 756272007387 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007388 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007389 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007390 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007391 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007392 Sulfatase; Region: Sulfatase; pfam00884 756272007393 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007394 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272007395 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272007396 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272007397 Amidohydrolase; Region: Amidohydro_2; pfam04909 756272007398 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 756272007399 active site 756272007400 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272007401 active site 756272007402 catalytic triad [active] 756272007403 oxyanion hole [active] 756272007404 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272007405 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 756272007406 Cytochrome c; Region: Cytochrom_C; pfam00034 756272007407 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272007408 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007409 Sulfatase; Region: Sulfatase; pfam00884 756272007410 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272007411 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 756272007412 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272007413 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272007414 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 756272007415 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007416 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007417 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 756272007418 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007419 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 756272007420 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007421 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007422 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007423 Sulfatase; Region: Sulfatase; cl17466 756272007424 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272007425 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272007426 active site 756272007427 metal binding site [ion binding]; metal-binding site 756272007428 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 756272007429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272007430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272007431 binding surface 756272007432 TPR motif; other site 756272007433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272007434 binding surface 756272007435 TPR motif; other site 756272007436 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007437 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007438 Uncharacterized conserved protein [Function unknown]; Region: COG1432 756272007439 LabA_like proteins; Region: LabA_like; cd06167 756272007440 putative metal binding site [ion binding]; other site 756272007441 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 756272007442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 756272007443 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 756272007444 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 756272007445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272007446 Helix-turn-helix domain; Region: HTH_18; pfam12833 756272007447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272007448 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 756272007449 active site 756272007450 Zn binding site [ion binding]; other site 756272007451 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 756272007452 intracellular protease, PfpI family; Region: PfpI; TIGR01382 756272007453 conserved cys residue [active] 756272007454 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007455 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007456 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272007457 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 756272007458 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272007459 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 756272007461 DNA binding residues [nucleotide binding] 756272007462 FecR protein; Region: FecR; pfam04773 756272007463 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007464 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007465 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007466 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007467 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007468 TROVE domain; Region: TROVE; pfam05731 756272007469 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 756272007470 metal ion-dependent adhesion site (MIDAS); other site 756272007471 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272007472 FtsX-like permease family; Region: FtsX; pfam02687 756272007473 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 756272007474 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272007475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272007476 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272007477 Walker A/P-loop; other site 756272007478 ATP binding site [chemical binding]; other site 756272007479 Q-loop/lid; other site 756272007480 ABC transporter signature motif; other site 756272007481 Walker B; other site 756272007482 D-loop; other site 756272007483 H-loop/switch region; other site 756272007484 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 756272007485 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272007486 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272007487 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272007488 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 756272007489 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272007490 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007491 Sulfatase; Region: Sulfatase; pfam00884 756272007492 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 756272007493 intersubunit interface [polypeptide binding]; other site 756272007494 active site 756272007495 Zn2+ binding site [ion binding]; other site 756272007496 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 756272007497 active site 756272007498 intersubunit interface [polypeptide binding]; other site 756272007499 Zn2+ binding site [ion binding]; other site 756272007500 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 756272007501 N- and C-terminal domain interface [polypeptide binding]; other site 756272007502 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 756272007503 active site 756272007504 putative catalytic site [active] 756272007505 metal binding site [ion binding]; metal-binding site 756272007506 ATP binding site [chemical binding]; other site 756272007507 carbohydrate binding site [chemical binding]; other site 756272007508 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 756272007509 L-rhamnose isomerase; Provisional; Region: PRK01076 756272007510 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 756272007511 transcriptional activator RhaR; Provisional; Region: PRK13502 756272007512 Cupin domain; Region: Cupin_2; pfam07883 756272007513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272007514 BNR repeat-like domain; Region: BNR_2; pfam13088 756272007515 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 756272007516 Galactose oxidase, central domain; Region: Kelch_3; cl02701 756272007517 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 756272007518 Na binding site [ion binding]; other site 756272007519 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272007520 Class I aldolases; Region: Aldolase_Class_I; cl17187 756272007521 catalytic residue [active] 756272007522 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 756272007523 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272007524 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 756272007525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272007526 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 756272007527 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 756272007528 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272007529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272007530 Utp11 protein; Region: Utp11; cl02164 756272007531 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272007532 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 756272007533 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 756272007534 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 756272007535 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 756272007536 active site 756272007537 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 756272007538 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 756272007539 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 756272007540 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 756272007541 KR domain; Region: KR; pfam08659 756272007542 putative NADP binding site [chemical binding]; other site 756272007543 active site 756272007544 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 756272007545 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 756272007546 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 756272007547 active site 756272007548 Acyl transferase domain; Region: Acyl_transf_1; cl08282 756272007549 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 756272007550 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 756272007551 acyl-activating enzyme (AAE) consensus motif; other site 756272007552 putative AMP binding site [chemical binding]; other site 756272007553 putative active site [active] 756272007554 putative CoA binding site [chemical binding]; other site 756272007555 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 756272007556 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 756272007557 active sites [active] 756272007558 tetramer interface [polypeptide binding]; other site 756272007559 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007560 Sulfatase; Region: Sulfatase; pfam00884 756272007561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272007562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 756272007563 DNA binding site [nucleotide binding] 756272007564 domain linker motif; other site 756272007565 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 756272007566 dimerization interface [polypeptide binding]; other site 756272007567 ligand binding site [chemical binding]; other site 756272007568 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 756272007569 active site 756272007570 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 756272007571 active site 756272007572 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 756272007573 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 756272007574 substrate binding site [chemical binding]; other site 756272007575 dimer interface [polypeptide binding]; other site 756272007576 ATP binding site [chemical binding]; other site 756272007577 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 756272007578 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 756272007579 ligand binding site [chemical binding]; other site 756272007580 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 756272007581 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 756272007582 Walker A/P-loop; other site 756272007583 ATP binding site [chemical binding]; other site 756272007584 Q-loop/lid; other site 756272007585 ABC transporter signature motif; other site 756272007586 Walker B; other site 756272007587 D-loop; other site 756272007588 H-loop/switch region; other site 756272007589 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 756272007590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 756272007591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 756272007592 TM-ABC transporter signature motif; other site 756272007593 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 756272007594 active site 756272007595 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 756272007596 active site 756272007597 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007598 Sulfatase; Region: Sulfatase; pfam00884 756272007599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007600 Sulfatase; Region: Sulfatase; pfam00884 756272007601 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272007602 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 756272007603 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 756272007604 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 756272007605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272007606 putative substrate translocation pore; other site 756272007607 Sulfatase; Region: Sulfatase; cl17466 756272007608 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007609 Sulfatase; Region: Sulfatase; pfam00884 756272007610 Sulfatase; Region: Sulfatase; cl17466 756272007611 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 756272007612 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 756272007613 putative active site [active] 756272007614 catalytic site [active] 756272007615 putative metal binding site [ion binding]; other site 756272007616 Sulfatase; Region: Sulfatase; cl17466 756272007617 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007618 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007619 Sulfatase; Region: Sulfatase; pfam00884 756272007620 Domain of unknown function DUF20; Region: UPF0118; pfam01594 756272007621 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 756272007622 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272007623 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272007624 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272007625 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272007626 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 756272007627 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 756272007628 active site 756272007629 intersubunit interface [polypeptide binding]; other site 756272007630 catalytic residue [active] 756272007631 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 756272007632 dimer interface [polypeptide binding]; other site 756272007633 type II secretion system protein D; Region: type_II_gspD; TIGR02517 756272007634 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007635 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007636 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007637 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 756272007638 type II secretion system protein E; Region: type_II_gspE; TIGR02533 756272007639 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 756272007640 Walker A motif; other site 756272007641 ATP binding site [chemical binding]; other site 756272007642 Walker B motif; other site 756272007643 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 756272007644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272007645 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272007646 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 756272007647 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 756272007648 type II secretion system protein I; Region: gspI; TIGR01707 756272007649 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 756272007650 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 756272007651 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 756272007652 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 756272007653 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007654 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007655 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007656 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 756272007657 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 756272007658 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 756272007659 BON domain; Region: BON; pfam04972 756272007660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272007661 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272007662 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 756272007663 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 756272007664 oligomer interface [polypeptide binding]; other site 756272007665 metal binding site [ion binding]; metal-binding site 756272007666 metal binding site [ion binding]; metal-binding site 756272007667 Cl binding site [ion binding]; other site 756272007668 aspartate ring; other site 756272007669 basic sphincter; other site 756272007670 putative hydrophobic gate; other site 756272007671 periplasmic entrance; other site 756272007672 Predicted permease; Region: DUF318; cl17795 756272007673 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 756272007674 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 756272007675 ligand binding site [chemical binding]; other site 756272007676 flexible hinge region; other site 756272007677 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007678 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007679 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007680 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007681 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007682 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 756272007683 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 756272007684 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 756272007685 shikimate binding site; other site 756272007686 NAD(P) binding site [chemical binding]; other site 756272007687 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 756272007688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272007689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272007690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272007691 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 756272007692 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272007693 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272007694 Cytochrome c; Region: Cytochrom_C; pfam00034 756272007695 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007696 Sulfatase; Region: Sulfatase; pfam00884 756272007697 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272007698 Sulfatase; Region: Sulfatase; cl17466 756272007699 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007700 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007701 Sulfatase; Region: Sulfatase; pfam00884 756272007702 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007703 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007704 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007705 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007706 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007707 Sulfatase; Region: Sulfatase; cl17466 756272007708 FecR protein; Region: FecR; pfam04773 756272007709 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272007710 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272007711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007712 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007713 Sulfatase; Region: Sulfatase; cl17466 756272007714 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007715 Sulfatase; Region: Sulfatase; pfam00884 756272007716 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 756272007717 putative dimerization interface [polypeptide binding]; other site 756272007718 putative ligand binding site [chemical binding]; other site 756272007719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272007720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272007721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272007722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272007723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272007724 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272007725 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 756272007726 putative active site [active] 756272007727 putative metal binding site [ion binding]; other site 756272007728 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272007729 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 756272007730 intracellular protease, PfpI family; Region: PfpI; TIGR01382 756272007731 conserved cys residue [active] 756272007732 high affinity sulphate transporter 1; Region: sulP; TIGR00815 756272007733 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 756272007734 Sulfate transporter family; Region: Sulfate_transp; pfam00916 756272007735 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 756272007736 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 756272007737 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 756272007738 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 756272007739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007741 dimer interface [polypeptide binding]; other site 756272007742 phosphorylation site [posttranslational modification] 756272007743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007744 ATP binding site [chemical binding]; other site 756272007745 Mg2+ binding site [ion binding]; other site 756272007746 G-X-G motif; other site 756272007747 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007749 active site 756272007750 phosphorylation site [posttranslational modification] 756272007751 intermolecular recognition site; other site 756272007752 dimerization interface [polypeptide binding]; other site 756272007753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272007754 Walker A motif; other site 756272007755 ATP binding site [chemical binding]; other site 756272007756 Walker B motif; other site 756272007757 arginine finger; other site 756272007758 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272007759 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 756272007760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272007761 DNA binding residues [nucleotide binding] 756272007762 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272007763 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272007764 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272007765 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272007766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007767 Sulfatase; Region: Sulfatase; pfam00884 756272007768 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272007769 HEAT repeats; Region: HEAT_2; pfam13646 756272007770 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272007771 Cytochrome c; Region: Cytochrom_C; pfam00034 756272007772 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272007773 Sulfatase; Region: Sulfatase; pfam00884 756272007774 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 756272007775 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272007776 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272007777 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 756272007778 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 756272007779 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272007780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272007781 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272007782 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272007783 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272007784 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272007785 active site 756272007786 ATP binding site [chemical binding]; other site 756272007787 substrate binding site [chemical binding]; other site 756272007788 activation loop (A-loop); other site 756272007789 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 756272007790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007791 active site 756272007792 phosphorylation site [posttranslational modification] 756272007793 intermolecular recognition site; other site 756272007794 dimerization interface [polypeptide binding]; other site 756272007795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272007796 DNA binding residues [nucleotide binding] 756272007797 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 756272007798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007799 putative active site [active] 756272007800 heme pocket [chemical binding]; other site 756272007801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007802 dimer interface [polypeptide binding]; other site 756272007803 phosphorylation site [posttranslational modification] 756272007804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007805 ATP binding site [chemical binding]; other site 756272007806 Mg2+ binding site [ion binding]; other site 756272007807 G-X-G motif; other site 756272007808 sulfite reductase; Provisional; Region: PRK06214 756272007809 Putative Fe-S cluster; Region: FeS; cl17515 756272007810 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 756272007811 FAD binding pocket [chemical binding]; other site 756272007812 FAD binding motif [chemical binding]; other site 756272007813 catalytic residues [active] 756272007814 NAD binding pocket [chemical binding]; other site 756272007815 phosphate binding motif [ion binding]; other site 756272007816 beta-alpha-beta structure motif; other site 756272007817 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 756272007818 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 756272007819 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 756272007820 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 756272007821 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 756272007822 [4Fe-4S] binding site [ion binding]; other site 756272007823 molybdopterin cofactor binding site; other site 756272007824 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 756272007825 molybdopterin cofactor binding site; other site 756272007826 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 756272007827 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 756272007828 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 756272007829 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 756272007830 Walker A/P-loop; other site 756272007831 ATP binding site [chemical binding]; other site 756272007832 Q-loop/lid; other site 756272007833 ABC transporter signature motif; other site 756272007834 Walker B; other site 756272007835 D-loop; other site 756272007836 H-loop/switch region; other site 756272007837 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 756272007838 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 756272007839 Walker A/P-loop; other site 756272007840 ATP binding site [chemical binding]; other site 756272007841 Q-loop/lid; other site 756272007842 ABC transporter signature motif; other site 756272007843 Walker B; other site 756272007844 D-loop; other site 756272007845 H-loop/switch region; other site 756272007846 Reactive mitochondrial oxygen species modulator 1; Region: Romo1; pfam10247 756272007847 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 756272007848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272007849 dimer interface [polypeptide binding]; other site 756272007850 conserved gate region; other site 756272007851 putative PBP binding loops; other site 756272007852 ABC-ATPase subunit interface; other site 756272007853 NMT1-like family; Region: NMT1_2; pfam13379 756272007854 NMT1/THI5 like; Region: NMT1; pfam09084 756272007855 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 756272007856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272007857 classical (c) SDRs; Region: SDR_c; cd05233 756272007858 NAD(P) binding site [chemical binding]; other site 756272007859 active site 756272007860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007861 PAS fold; Region: PAS_3; pfam08447 756272007862 putative active site [active] 756272007863 heme pocket [chemical binding]; other site 756272007864 PAS domain S-box; Region: sensory_box; TIGR00229 756272007865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007866 putative active site [active] 756272007867 heme pocket [chemical binding]; other site 756272007868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007870 phosphorylation site [posttranslational modification] 756272007871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007872 ATP binding site [chemical binding]; other site 756272007873 Mg2+ binding site [ion binding]; other site 756272007874 G-X-G motif; other site 756272007875 Response regulator receiver domain; Region: Response_reg; pfam00072 756272007876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007877 active site 756272007878 phosphorylation site [posttranslational modification] 756272007879 intermolecular recognition site; other site 756272007880 dimerization interface [polypeptide binding]; other site 756272007881 Hpt domain; Region: Hpt; pfam01627 756272007882 putative binding surface; other site 756272007883 active site 756272007884 Response regulator receiver domain; Region: Response_reg; pfam00072 756272007885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007886 active site 756272007887 phosphorylation site [posttranslational modification] 756272007888 intermolecular recognition site; other site 756272007889 dimerization interface [polypeptide binding]; other site 756272007890 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 756272007891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007892 active site 756272007893 phosphorylation site [posttranslational modification] 756272007894 intermolecular recognition site; other site 756272007895 dimerization interface [polypeptide binding]; other site 756272007896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272007897 DNA binding residues [nucleotide binding] 756272007898 dimerization interface [polypeptide binding]; other site 756272007899 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 756272007900 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 756272007901 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 756272007902 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 756272007903 ATP binding site [chemical binding]; other site 756272007904 Walker A motif; other site 756272007905 hexamer interface [polypeptide binding]; other site 756272007906 Walker B motif; other site 756272007907 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 756272007908 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272007909 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 756272007910 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272007911 PAS fold; Region: PAS; pfam00989 756272007912 PAS domain; Region: PAS; smart00091 756272007913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007914 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272007915 putative active site [active] 756272007916 heme pocket [chemical binding]; other site 756272007917 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272007918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007919 putative active site [active] 756272007920 heme pocket [chemical binding]; other site 756272007921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007922 PAS fold; Region: PAS_3; pfam08447 756272007923 putative active site [active] 756272007924 heme pocket [chemical binding]; other site 756272007925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272007926 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272007927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007929 dimer interface [polypeptide binding]; other site 756272007930 phosphorylation site [posttranslational modification] 756272007931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007932 ATP binding site [chemical binding]; other site 756272007933 Mg2+ binding site [ion binding]; other site 756272007934 G-X-G motif; other site 756272007935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007937 active site 756272007938 phosphorylation site [posttranslational modification] 756272007939 intermolecular recognition site; other site 756272007940 dimerization interface [polypeptide binding]; other site 756272007941 Predicted transcriptional regulator [Transcription]; Region: COG2345 756272007942 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 756272007943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272007944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 756272007945 DNA binding residues [nucleotide binding] 756272007946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272007947 active site 756272007948 ATP binding site [chemical binding]; other site 756272007949 substrate binding site [chemical binding]; other site 756272007950 activation loop (A-loop); other site 756272007951 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272007952 anti sigma factor interaction site; other site 756272007953 regulatory phosphorylation site [posttranslational modification]; other site 756272007954 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272007955 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272007956 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272007957 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272007958 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272007959 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272007960 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272007961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007962 PAS domain; Region: PAS_9; pfam13426 756272007963 putative active site [active] 756272007964 heme pocket [chemical binding]; other site 756272007965 GAF domain; Region: GAF_3; pfam13492 756272007966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007967 PAS fold; Region: PAS_3; pfam08447 756272007968 putative active site [active] 756272007969 heme pocket [chemical binding]; other site 756272007970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007971 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272007972 putative active site [active] 756272007973 heme pocket [chemical binding]; other site 756272007974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272007975 putative active site [active] 756272007976 heme pocket [chemical binding]; other site 756272007977 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272007978 GAF domain; Region: GAF_2; pfam13185 756272007979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272007980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272007981 dimer interface [polypeptide binding]; other site 756272007982 phosphorylation site [posttranslational modification] 756272007983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272007984 ATP binding site [chemical binding]; other site 756272007985 Mg2+ binding site [ion binding]; other site 756272007986 G-X-G motif; other site 756272007987 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272007988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272007989 active site 756272007990 phosphorylation site [posttranslational modification] 756272007991 intermolecular recognition site; other site 756272007992 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 756272007993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272007994 FeS/SAM binding site; other site 756272007995 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 756272007996 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 756272007997 Fe-S cluster binding site [ion binding]; other site 756272007998 active site 756272007999 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 756272008000 classical (c) SDRs; Region: SDR_c; cd05233 756272008001 NAD(P) binding site [chemical binding]; other site 756272008002 active site 756272008003 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 756272008004 hydroperoxidase II; Provisional; Region: katE; PRK11249 756272008005 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 756272008006 heme binding pocket [chemical binding]; other site 756272008007 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 756272008008 domain interactions; other site 756272008009 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 756272008010 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 756272008011 putative ADP-binding pocket [chemical binding]; other site 756272008012 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 756272008013 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 756272008014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272008015 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 756272008016 putative ADP-binding pocket [chemical binding]; other site 756272008017 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 756272008018 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 756272008019 Response regulator receiver domain; Region: Response_reg; pfam00072 756272008020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008021 active site 756272008022 phosphorylation site [posttranslational modification] 756272008023 intermolecular recognition site; other site 756272008024 dimerization interface [polypeptide binding]; other site 756272008025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272008026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008027 ATP binding site [chemical binding]; other site 756272008028 Mg2+ binding site [ion binding]; other site 756272008029 G-X-G motif; other site 756272008030 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008031 Sulfatase; Region: Sulfatase; cl17466 756272008032 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272008033 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008034 Sulfatase; Region: Sulfatase; pfam00884 756272008035 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008036 Sulfatase; Region: Sulfatase; pfam00884 756272008037 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 756272008038 active site 756272008039 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 756272008040 Na binding site [ion binding]; other site 756272008041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 756272008042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272008043 Coenzyme A binding pocket [chemical binding]; other site 756272008044 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 756272008045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 756272008046 inhibitor-cofactor binding pocket; inhibition site 756272008047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272008048 catalytic residue [active] 756272008049 Ectoine synthase; Region: Ectoine_synth; pfam06339 756272008050 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 756272008051 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 756272008052 MarR family; Region: MarR_2; cl17246 756272008053 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 756272008054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 756272008055 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 756272008056 Walker A/P-loop; other site 756272008057 ATP binding site [chemical binding]; other site 756272008058 Q-loop/lid; other site 756272008059 ABC transporter signature motif; other site 756272008060 Walker B; other site 756272008061 D-loop; other site 756272008062 H-loop/switch region; other site 756272008063 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008064 Sulfatase; Region: Sulfatase; cl17466 756272008065 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008066 Sulfatase; Region: Sulfatase; cl17466 756272008067 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272008068 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 756272008069 polymerase nucleotide-binding site; other site 756272008070 DNA-binding residues [nucleotide binding]; DNA binding site 756272008071 nucleotide binding site [chemical binding]; other site 756272008072 primase nucleotide-binding site [nucleotide binding]; other site 756272008073 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 756272008074 AAA domain; Region: AAA_25; pfam13481 756272008075 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 756272008076 ATP binding site [chemical binding]; other site 756272008077 Walker B motif; other site 756272008078 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 756272008079 oligomer interface [polypeptide binding]; other site 756272008080 Clp protease; Region: CLP_protease; pfam00574 756272008081 active site residues [active] 756272008082 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 756272008083 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 756272008084 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 756272008085 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272008086 active site 756272008087 catalytic residues [active] 756272008088 DNA binding site [nucleotide binding] 756272008089 Int/Topo IB signature motif; other site 756272008090 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 756272008091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272008092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272008093 DNA binding residues [nucleotide binding] 756272008094 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 756272008095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272008096 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272008097 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 756272008098 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 756272008099 catalytic residues [active] 756272008100 dimer interface [polypeptide binding]; other site 756272008101 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272008102 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272008103 structural tetrad; other site 756272008104 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272008105 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 756272008106 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272008107 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272008108 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 756272008109 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 756272008110 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272008111 Methyltransferase domain; Region: Methyltransf_26; pfam13659 756272008112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272008113 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 756272008114 dimerization interface [polypeptide binding]; other site 756272008115 putative tRNAtyr binding site [nucleotide binding]; other site 756272008116 putative active site [active] 756272008117 Response regulator receiver domain; Region: Response_reg; pfam00072 756272008118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008119 active site 756272008120 phosphorylation site [posttranslational modification] 756272008121 intermolecular recognition site; other site 756272008122 dimerization interface [polypeptide binding]; other site 756272008123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272008124 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272008125 active site 756272008126 ATP binding site [chemical binding]; other site 756272008127 substrate binding site [chemical binding]; other site 756272008128 activation loop (A-loop); other site 756272008129 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272008130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272008131 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 756272008132 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 756272008133 active site 756272008134 NTP binding site [chemical binding]; other site 756272008135 metal binding triad [ion binding]; metal-binding site 756272008136 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 756272008137 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 756272008138 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 756272008139 Filamin/ABP280 repeat; Region: Filamin; pfam00630 756272008140 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 756272008141 CARDB; Region: CARDB; pfam07705 756272008142 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 756272008143 [2Fe-2S] cluster binding site [ion binding]; other site 756272008144 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 756272008145 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 756272008146 FeS assembly protein SufD; Region: sufD; TIGR01981 756272008147 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 756272008148 FeS assembly protein SufB; Region: sufB; TIGR01980 756272008149 FeS assembly ATPase SufC; Region: sufC; TIGR01978 756272008150 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 756272008151 Walker A/P-loop; other site 756272008152 ATP binding site [chemical binding]; other site 756272008153 Q-loop/lid; other site 756272008154 ABC transporter signature motif; other site 756272008155 Walker B; other site 756272008156 D-loop; other site 756272008157 H-loop/switch region; other site 756272008158 Predicted transcriptional regulator [Transcription]; Region: COG2345 756272008159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272008160 putative DNA binding site [nucleotide binding]; other site 756272008161 putative Zn2+ binding site [ion binding]; other site 756272008162 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 756272008163 Na2 binding site [ion binding]; other site 756272008164 substrate binding site 1 [chemical binding]; other site 756272008165 Na binding site 1 [ion binding]; other site 756272008166 substrate binding site 2 [chemical binding]; other site 756272008167 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272008168 Protein export membrane protein; Region: SecD_SecF; cl14618 756272008169 Protein export membrane protein; Region: SecD_SecF; cl14618 756272008170 Methane oxygenase PmoA; Region: PmoA; pfam14100 756272008171 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272008172 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272008173 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 756272008174 active site 756272008175 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 756272008176 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 756272008177 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 756272008178 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 756272008179 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 756272008180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 756272008181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 756272008182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272008183 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 756272008184 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 756272008185 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 756272008186 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272008187 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 756272008188 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 756272008189 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 756272008190 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272008191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272008192 S-adenosylmethionine binding site [chemical binding]; other site 756272008193 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 756272008194 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272008195 catalytic residues [active] 756272008196 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 756272008197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272008198 putative catalytic residue [active] 756272008199 Haem-binding domain; Region: Haem_bd; pfam14376 756272008200 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 756272008201 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 756272008202 Protein export membrane protein; Region: SecD_SecF; cl14618 756272008203 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 756272008204 GIY-YIG motif/motif A; other site 756272008205 putative active site [active] 756272008206 putative metal binding site [ion binding]; other site 756272008207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272008208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 756272008209 DNA binding site [nucleotide binding] 756272008210 domain linker motif; other site 756272008211 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 756272008212 dimerization interface [polypeptide binding]; other site 756272008213 ligand binding site [chemical binding]; other site 756272008214 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 756272008215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 756272008216 active site 756272008217 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 756272008218 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 756272008219 active site 756272008220 trimer interface [polypeptide binding]; other site 756272008221 allosteric site; other site 756272008222 active site lid [active] 756272008223 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272008224 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272008225 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272008226 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 756272008227 Ligand binding site; other site 756272008228 Putative Catalytic site; other site 756272008229 DXD motif; other site 756272008230 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008231 Sulfatase; Region: Sulfatase; pfam00884 756272008232 BNR repeat-like domain; Region: BNR_2; pfam13088 756272008233 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 756272008234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 756272008235 TM-ABC transporter signature motif; other site 756272008236 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 756272008237 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 756272008238 putative active site pocket [active] 756272008239 4-fold oligomerization interface [polypeptide binding]; other site 756272008240 metal binding residues [ion binding]; metal-binding site 756272008241 3-fold/trimer interface [polypeptide binding]; other site 756272008242 MutL protein; Region: MutL; pfam13941 756272008243 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 756272008244 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272008245 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 756272008246 putative rRNA binding site [nucleotide binding]; other site 756272008247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272008248 Methyltransferase domain; Region: Methyltransf_31; pfam13847 756272008249 S-adenosylmethionine binding site [chemical binding]; other site 756272008250 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 756272008251 UvrB/uvrC motif; Region: UVR; pfam02151 756272008252 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 756272008253 putative active site [active] 756272008254 putative metal binding residues [ion binding]; other site 756272008255 signature motif; other site 756272008256 putative triphosphate binding site [ion binding]; other site 756272008257 dimer interface [polypeptide binding]; other site 756272008258 Protein of unknown function (DUF971); Region: DUF971; pfam06155 756272008259 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272008260 active site 756272008261 metal binding site [ion binding]; metal-binding site 756272008262 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 756272008263 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 756272008264 O-Antigen ligase; Region: Wzy_C; pfam04932 756272008265 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 756272008266 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 756272008267 Mg++ binding site [ion binding]; other site 756272008268 putative catalytic motif [active] 756272008269 substrate binding site [chemical binding]; other site 756272008270 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008271 Sulfatase; Region: Sulfatase; cl17466 756272008272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272008273 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272008274 phosphopeptide binding site; other site 756272008275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272008276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272008277 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272008278 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272008279 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 756272008280 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 756272008281 transmembrane helices; other site 756272008282 HDOD domain; Region: HDOD; pfam08668 756272008283 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 756272008284 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 756272008285 metal binding site [ion binding]; metal-binding site 756272008286 active site 756272008287 I-site; other site 756272008288 Response regulator receiver domain; Region: Response_reg; pfam00072 756272008289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008290 active site 756272008291 phosphorylation site [posttranslational modification] 756272008292 intermolecular recognition site; other site 756272008293 dimerization interface [polypeptide binding]; other site 756272008294 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 756272008295 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 756272008296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 756272008297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272008298 DNA binding residues [nucleotide binding] 756272008299 dimerization interface [polypeptide binding]; other site 756272008300 AAA domain; Region: AAA_22; pfam13401 756272008301 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 756272008302 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 756272008303 Protein phosphatase 2C; Region: PP2C; pfam00481 756272008304 active site 756272008305 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 756272008306 TPR repeat; Region: TPR_11; pfam13414 756272008307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272008308 binding surface 756272008309 TPR motif; other site 756272008310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272008311 TPR motif; other site 756272008312 TPR repeat; Region: TPR_11; pfam13414 756272008313 binding surface 756272008314 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 756272008315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008316 ATP binding site [chemical binding]; other site 756272008317 Mg2+ binding site [ion binding]; other site 756272008318 G-X-G motif; other site 756272008319 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 756272008320 ATP binding site [chemical binding]; other site 756272008321 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 756272008322 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 756272008323 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 756272008324 Ligand Binding Site [chemical binding]; other site 756272008325 ribonuclease Y; Region: RNase_Y; TIGR03319 756272008326 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272008327 Zn2+ binding site [ion binding]; other site 756272008328 Mg2+ binding site [ion binding]; other site 756272008329 anthranilate synthase component I; Provisional; Region: PRK13565 756272008330 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 756272008331 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 756272008332 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 756272008333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272008334 FeS/SAM binding site; other site 756272008335 HemN C-terminal domain; Region: HemN_C; pfam06969 756272008336 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 756272008337 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 756272008338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272008339 FeS/SAM binding site; other site 756272008340 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 756272008341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 756272008342 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 756272008343 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 756272008344 active site 756272008345 dimer interface [polypeptide binding]; other site 756272008346 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 756272008347 Ligand Binding Site [chemical binding]; other site 756272008348 Molecular Tunnel; other site 756272008349 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 756272008350 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 756272008351 putative ADP-binding pocket [chemical binding]; other site 756272008352 TPR repeat; Region: TPR_11; pfam13414 756272008353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272008354 binding surface 756272008355 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272008356 TPR motif; other site 756272008357 TPR repeat; Region: TPR_11; pfam13414 756272008358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272008359 TPR repeat; Region: TPR_11; pfam13414 756272008360 binding surface 756272008361 TPR motif; other site 756272008362 TPR repeat; Region: TPR_11; pfam13414 756272008363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272008364 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 756272008365 DNA protecting protein DprA; Region: dprA; TIGR00732 756272008366 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 756272008367 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 756272008368 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 756272008369 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 756272008370 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 756272008371 MOFRL family; Region: MOFRL; pfam05161 756272008372 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 756272008373 Haem-binding domain; Region: Haem_bd; pfam14376 756272008374 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 756272008375 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 756272008376 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272008377 Walker A/P-loop; other site 756272008378 ATP binding site [chemical binding]; other site 756272008379 Q-loop/lid; other site 756272008380 ABC transporter signature motif; other site 756272008381 Walker B; other site 756272008382 D-loop; other site 756272008383 H-loop/switch region; other site 756272008384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 756272008385 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 756272008386 ABC-ATPase subunit interface; other site 756272008387 dimer interface [polypeptide binding]; other site 756272008388 putative PBP binding regions; other site 756272008389 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 756272008390 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 756272008391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272008392 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 756272008393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272008394 DNA binding residues [nucleotide binding] 756272008395 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 756272008396 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008397 Sulfatase; Region: Sulfatase; pfam00884 756272008398 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272008399 HEAT repeats; Region: HEAT_2; pfam13646 756272008400 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008401 Sulfatase; Region: Sulfatase; pfam00884 756272008402 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 756272008403 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 756272008404 active site 756272008405 interdomain interaction site; other site 756272008406 putative metal-binding site [ion binding]; other site 756272008407 nucleotide binding site [chemical binding]; other site 756272008408 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 756272008409 domain I; other site 756272008410 phosphate binding site [ion binding]; other site 756272008411 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 756272008412 domain II; other site 756272008413 domain III; other site 756272008414 nucleotide binding site [chemical binding]; other site 756272008415 DNA binding groove [nucleotide binding] 756272008416 catalytic site [active] 756272008417 domain IV; other site 756272008418 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 756272008419 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 756272008420 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 756272008421 periplasmic folding chaperone; Provisional; Region: PRK10788 756272008422 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272008423 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272008424 phosphopeptide binding site; other site 756272008425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 756272008426 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 756272008427 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 756272008428 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 756272008429 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 756272008430 dimer interface [polypeptide binding]; other site 756272008431 active site 756272008432 FeoA domain; Region: FeoA; pfam04023 756272008433 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 756272008434 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 756272008435 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 756272008436 G1 box; other site 756272008437 GTP/Mg2+ binding site [chemical binding]; other site 756272008438 Switch I region; other site 756272008439 G2 box; other site 756272008440 G3 box; other site 756272008441 Switch II region; other site 756272008442 G4 box; other site 756272008443 G5 box; other site 756272008444 Nucleoside recognition; Region: Gate; pfam07670 756272008445 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 756272008446 Nucleoside recognition; Region: Gate; pfam07670 756272008447 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 756272008448 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 756272008449 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 756272008450 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 756272008451 nucleotide binding site [chemical binding]; other site 756272008452 putative NEF/HSP70 interaction site [polypeptide binding]; other site 756272008453 SBD interface [polypeptide binding]; other site 756272008454 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 756272008455 Sulfatase; Region: Sulfatase; pfam00884 756272008456 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272008457 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 756272008458 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 756272008459 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 756272008460 active site 756272008461 catalytic site [active] 756272008462 Predicted permeases [General function prediction only]; Region: COG0795 756272008463 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 756272008464 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 756272008465 putative binding surface; other site 756272008466 active site 756272008467 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272008468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272008469 NAD(P) binding site [chemical binding]; other site 756272008470 active site 756272008471 replicative DNA helicase; Region: DnaB; TIGR00665 756272008472 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 756272008473 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 756272008474 Walker A motif; other site 756272008475 ATP binding site [chemical binding]; other site 756272008476 Walker B motif; other site 756272008477 DNA binding loops [nucleotide binding] 756272008478 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 756272008479 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 756272008480 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 756272008481 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 756272008482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 756272008483 dimer interface [polypeptide binding]; other site 756272008484 ssDNA binding site [nucleotide binding]; other site 756272008485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 756272008486 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 756272008487 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 756272008488 putative active site [active] 756272008489 catalytic residue [active] 756272008490 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 756272008491 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 756272008492 5S rRNA interface [nucleotide binding]; other site 756272008493 CTC domain interface [polypeptide binding]; other site 756272008494 L16 interface [polypeptide binding]; other site 756272008495 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 756272008496 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 756272008497 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 756272008498 Ligand binding site; other site 756272008499 Putative Catalytic site; other site 756272008500 DXD motif; other site 756272008501 Predicted membrane protein [Function unknown]; Region: COG2246 756272008502 GtrA-like protein; Region: GtrA; pfam04138 756272008503 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272008504 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272008505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272008506 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272008507 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272008508 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 756272008509 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 756272008510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272008511 Walker A/P-loop; other site 756272008512 ATP binding site [chemical binding]; other site 756272008513 Q-loop/lid; other site 756272008514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272008515 ABC transporter signature motif; other site 756272008516 Walker B; other site 756272008517 D-loop; other site 756272008518 H-loop/switch region; other site 756272008519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272008520 Walker A/P-loop; other site 756272008521 ATP binding site [chemical binding]; other site 756272008522 Q-loop/lid; other site 756272008523 ABC transporter signature motif; other site 756272008524 Walker B; other site 756272008525 D-loop; other site 756272008526 H-loop/switch region; other site 756272008527 ScpA/B protein; Region: ScpA_ScpB; cl00598 756272008528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272008529 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272008530 FtsX-like permease family; Region: FtsX; pfam02687 756272008531 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272008532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272008533 Walker A/P-loop; other site 756272008534 ATP binding site [chemical binding]; other site 756272008535 Q-loop/lid; other site 756272008536 ABC transporter signature motif; other site 756272008537 Walker B; other site 756272008538 D-loop; other site 756272008539 H-loop/switch region; other site 756272008540 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 756272008541 DNA photolyase; Region: DNA_photolyase; pfam00875 756272008542 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 756272008543 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 756272008544 putative valine binding site [chemical binding]; other site 756272008545 dimer interface [polypeptide binding]; other site 756272008546 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 756272008547 ketol-acid reductoisomerase; Provisional; Region: PRK05479 756272008548 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 756272008549 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 756272008550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 756272008551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272008552 DNA binding residues [nucleotide binding] 756272008553 dimerization interface [polypeptide binding]; other site 756272008554 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 756272008555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008556 active site 756272008557 phosphorylation site [posttranslational modification] 756272008558 intermolecular recognition site; other site 756272008559 dimerization interface [polypeptide binding]; other site 756272008560 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 756272008561 dimerization interface [polypeptide binding]; other site 756272008562 DNA binding residues [nucleotide binding] 756272008563 PAS fold; Region: PAS_4; pfam08448 756272008564 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 756272008565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272008566 dimer interface [polypeptide binding]; other site 756272008567 phosphorylation site [posttranslational modification] 756272008568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008569 ATP binding site [chemical binding]; other site 756272008570 Mg2+ binding site [ion binding]; other site 756272008571 G-X-G motif; other site 756272008572 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 756272008573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272008574 putative catalytic residue [active] 756272008575 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 756272008576 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 756272008577 FAD binding domain; Region: FAD_binding_4; pfam01565 756272008578 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 756272008579 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272008580 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 756272008581 active site 756272008582 phosphorylation site [posttranslational modification] 756272008583 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272008584 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272008585 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 756272008586 GTP1/OBG; Region: GTP1_OBG; pfam01018 756272008587 Obg GTPase; Region: Obg; cd01898 756272008588 G1 box; other site 756272008589 GTP/Mg2+ binding site [chemical binding]; other site 756272008590 Switch I region; other site 756272008591 G2 box; other site 756272008592 G3 box; other site 756272008593 Switch II region; other site 756272008594 G4 box; other site 756272008595 G5 box; other site 756272008596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272008597 Walker A/P-loop; other site 756272008598 ATP binding site [chemical binding]; other site 756272008599 Q-loop/lid; other site 756272008600 ABC transporter signature motif; other site 756272008601 D-loop; other site 756272008602 H-loop/switch region; other site 756272008603 Protein of unknown function (DUF447); Region: DUF447; pfam04289 756272008604 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 756272008605 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 756272008606 Ycf46; Provisional; Region: ycf46; CHL00195 756272008607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272008608 Walker A motif; other site 756272008609 ATP binding site [chemical binding]; other site 756272008610 Walker B motif; other site 756272008611 arginine finger; other site 756272008612 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 756272008613 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 756272008614 active site 756272008615 catalytic residue [active] 756272008616 dimer interface [polypeptide binding]; other site 756272008617 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 756272008618 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 756272008619 shikimate binding site; other site 756272008620 NAD(P) binding site [chemical binding]; other site 756272008621 shikimate kinase; Reviewed; Region: aroK; PRK00131 756272008622 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 756272008623 ADP binding site [chemical binding]; other site 756272008624 magnesium binding site [ion binding]; other site 756272008625 putative shikimate binding site; other site 756272008626 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 756272008627 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 756272008628 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 756272008629 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 756272008630 putative active site [active] 756272008631 oxyanion strand; other site 756272008632 catalytic triad [active] 756272008633 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 756272008634 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 756272008635 catalytic residues [active] 756272008636 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 756272008637 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 756272008638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008639 Mg2+ binding site [ion binding]; other site 756272008640 G-X-G motif; other site 756272008641 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 756272008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 756272008643 Mg2+ binding site [ion binding]; other site 756272008644 G-X-G motif; other site 756272008645 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272008646 anti sigma factor interaction site; other site 756272008647 regulatory phosphorylation site [posttranslational modification]; other site 756272008648 Uncharacterized conserved protein [Function unknown]; Region: COG4850 756272008649 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 756272008650 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272008651 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 756272008652 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 756272008653 homodimer interface [polypeptide binding]; other site 756272008654 substrate-cofactor binding pocket; other site 756272008655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272008656 catalytic residue [active] 756272008657 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272008658 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272008659 phosphopeptide binding site; other site 756272008660 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 756272008661 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272008662 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272008663 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272008664 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272008665 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 756272008666 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 756272008667 PA/protease or protease-like domain interface [polypeptide binding]; other site 756272008668 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 756272008669 Peptidase family M28; Region: Peptidase_M28; pfam04389 756272008670 metal binding site [ion binding]; metal-binding site 756272008671 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272008672 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 756272008673 active site lid residues [active] 756272008674 substrate binding pocket [chemical binding]; other site 756272008675 catalytic residues [active] 756272008676 substrate-Mg2+ binding site; other site 756272008677 aspartate-rich region 1; other site 756272008678 aspartate-rich region 2; other site 756272008679 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 756272008680 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 756272008681 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 756272008682 active site 756272008683 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 756272008684 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 756272008685 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 756272008686 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 756272008687 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 756272008688 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 756272008689 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 756272008690 PA/protease or protease-like domain interface [polypeptide binding]; other site 756272008691 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 756272008692 Peptidase family M28; Region: Peptidase_M28; pfam04389 756272008693 metal binding site [ion binding]; metal-binding site 756272008694 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272008695 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 756272008696 Ligand binding site; other site 756272008697 Putative Catalytic site; other site 756272008698 DXD motif; other site 756272008699 epoxyqueuosine reductase; Region: TIGR00276 756272008700 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 756272008701 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 756272008702 histidinol dehydrogenase; Region: hisD; TIGR00069 756272008703 NAD binding site [chemical binding]; other site 756272008704 dimerization interface [polypeptide binding]; other site 756272008705 product binding site; other site 756272008706 substrate binding site [chemical binding]; other site 756272008707 zinc binding site [ion binding]; other site 756272008708 catalytic residues [active] 756272008709 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 756272008710 active site 756272008711 dimer interface [polypeptide binding]; other site 756272008712 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 756272008713 dimer interface [polypeptide binding]; other site 756272008714 active site 756272008715 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 756272008716 MutS domain I; Region: MutS_I; pfam01624 756272008717 MutS domain II; Region: MutS_II; pfam05188 756272008718 MutS domain III; Region: MutS_III; pfam05192 756272008719 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 756272008720 Walker A/P-loop; other site 756272008721 ATP binding site [chemical binding]; other site 756272008722 Q-loop/lid; other site 756272008723 ABC transporter signature motif; other site 756272008724 Walker B; other site 756272008725 D-loop; other site 756272008726 H-loop/switch region; other site 756272008727 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272008728 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272008729 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 756272008730 active site 756272008731 catalytic residues [active] 756272008732 Competence-damaged protein; Region: CinA; pfam02464 756272008733 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 756272008734 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 756272008735 tetramer interface [polypeptide binding]; other site 756272008736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272008737 catalytic residue [active] 756272008738 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272008739 Leucine-rich repeats; other site 756272008740 Substrate binding site [chemical binding]; other site 756272008741 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 756272008742 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 756272008743 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272008744 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272008745 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 756272008746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272008747 active site 756272008748 HIGH motif; other site 756272008749 nucleotide binding site [chemical binding]; other site 756272008750 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 756272008751 active site 756272008752 KMSKS motif; other site 756272008753 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 756272008754 tRNA binding surface [nucleotide binding]; other site 756272008755 anticodon binding site; other site 756272008756 transcription termination factor NusA; Region: NusA; TIGR01953 756272008757 NusA N-terminal domain; Region: NusA_N; pfam08529 756272008758 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 756272008759 RNA binding site [nucleotide binding]; other site 756272008760 homodimer interface [polypeptide binding]; other site 756272008761 NusA-like KH domain; Region: KH_5; pfam13184 756272008762 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 756272008763 G-X-X-G motif; other site 756272008764 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 756272008765 translation initiation factor IF-2; Region: IF-2; TIGR00487 756272008766 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 756272008767 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 756272008768 G1 box; other site 756272008769 putative GEF interaction site [polypeptide binding]; other site 756272008770 GTP/Mg2+ binding site [chemical binding]; other site 756272008771 Switch I region; other site 756272008772 G2 box; other site 756272008773 G3 box; other site 756272008774 Switch II region; other site 756272008775 G4 box; other site 756272008776 G5 box; other site 756272008777 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 756272008778 Translation-initiation factor 2; Region: IF-2; pfam11987 756272008779 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 756272008780 Ribosome-binding factor A; Region: RBFA; pfam02033 756272008781 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 756272008782 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272008783 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272008784 active site 756272008785 metal binding site [ion binding]; metal-binding site 756272008786 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 756272008787 Putative zinc ribbon domain; Region: DUF164; pfam02591 756272008788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272008789 active site 756272008790 DinB superfamily; Region: DinB_2; pfam12867 756272008791 metal-dependent hydrolase; Provisional; Region: PRK13291 756272008792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 756272008793 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 756272008794 putative NAD(P) binding site [chemical binding]; other site 756272008795 catalytic Zn binding site [ion binding]; other site 756272008796 structural Zn binding site [ion binding]; other site 756272008797 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 756272008798 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 756272008799 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 756272008800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 756272008801 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 756272008802 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 756272008803 putative ADP-binding pocket [chemical binding]; other site 756272008804 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 756272008805 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 756272008806 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 756272008807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272008808 aspartate kinase; Provisional; Region: PRK07431 756272008809 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 756272008810 putative catalytic residues [active] 756272008811 putative nucleotide binding site [chemical binding]; other site 756272008812 putative aspartate binding site [chemical binding]; other site 756272008813 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 756272008814 putative allosteric regulatory site; other site 756272008815 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 756272008816 putative allosteric regulatory residue; other site 756272008817 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 756272008818 putative allosteric regulatory site; other site 756272008819 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 756272008820 putative allosteric regulatory residue; other site 756272008821 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 756272008822 4Fe-4S binding domain; Region: Fer4; cl02805 756272008823 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 756272008824 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 756272008825 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 756272008826 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 756272008827 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 756272008828 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 756272008829 Na binding site [ion binding]; other site 756272008830 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 756272008831 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 756272008832 catalytic triad [active] 756272008833 serine/threonine protein kinase; Provisional; Region: PRK12274 756272008834 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 756272008835 AzlC protein; Region: AzlC; cl00570 756272008836 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 756272008837 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 756272008838 pyruvate carboxylase; Reviewed; Region: PRK12999 756272008839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 756272008840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272008841 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 756272008842 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 756272008843 active site 756272008844 catalytic residues [active] 756272008845 metal binding site [ion binding]; metal-binding site 756272008846 homodimer binding site [polypeptide binding]; other site 756272008847 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 756272008848 carboxyltransferase (CT) interaction site; other site 756272008849 biotinylation site [posttranslational modification]; other site 756272008850 PQQ-like domain; Region: PQQ_2; pfam13360 756272008851 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272008852 active site 756272008853 Trp docking motif [polypeptide binding]; other site 756272008854 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272008855 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272008856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008857 active site 756272008858 phosphorylation site [posttranslational modification] 756272008859 intermolecular recognition site; other site 756272008860 dimerization interface [polypeptide binding]; other site 756272008861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272008862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272008863 dimer interface [polypeptide binding]; other site 756272008864 phosphorylation site [posttranslational modification] 756272008865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008866 ATP binding site [chemical binding]; other site 756272008867 Mg2+ binding site [ion binding]; other site 756272008868 G-X-G motif; other site 756272008869 Response regulator receiver domain; Region: Response_reg; pfam00072 756272008870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008871 active site 756272008872 phosphorylation site [posttranslational modification] 756272008873 intermolecular recognition site; other site 756272008874 dimerization interface [polypeptide binding]; other site 756272008875 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 756272008876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008877 active site 756272008878 phosphorylation site [posttranslational modification] 756272008879 intermolecular recognition site; other site 756272008880 dimerization interface [polypeptide binding]; other site 756272008881 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 756272008882 GAF domain; Region: GAF; pfam01590 756272008883 Phytochrome region; Region: PHY; pfam00360 756272008884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272008885 dimer interface [polypeptide binding]; other site 756272008886 phosphorylation site [posttranslational modification] 756272008887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272008888 ATP binding site [chemical binding]; other site 756272008889 Mg2+ binding site [ion binding]; other site 756272008890 G-X-G motif; other site 756272008891 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 756272008892 heme binding pocket [chemical binding]; other site 756272008893 heme ligand [chemical binding]; other site 756272008894 ABC transporter ATPase component; Reviewed; Region: PRK11147 756272008895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272008896 ABC transporter; Region: ABC_tran_2; pfam12848 756272008897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 756272008898 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 756272008899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 756272008900 pyruvate phosphate dikinase; Provisional; Region: PRK09279 756272008901 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 756272008902 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 756272008903 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 756272008904 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 756272008905 Methyltransferase domain; Region: Methyltransf_25; pfam13649 756272008906 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 756272008907 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 756272008908 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272008909 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 756272008910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272008911 dimer interface [polypeptide binding]; other site 756272008912 conserved gate region; other site 756272008913 putative PBP binding loops; other site 756272008914 ABC-ATPase subunit interface; other site 756272008915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272008916 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 756272008917 Walker A/P-loop; other site 756272008918 ATP binding site [chemical binding]; other site 756272008919 Q-loop/lid; other site 756272008920 ABC transporter signature motif; other site 756272008921 Walker B; other site 756272008922 D-loop; other site 756272008923 H-loop/switch region; other site 756272008924 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 756272008925 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 756272008926 Global regulator protein family; Region: CsrA; pfam02599 756272008927 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 756272008928 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272008929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272008930 active site 756272008931 metal binding site [ion binding]; metal-binding site 756272008932 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272008933 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272008934 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272008935 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272008936 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272008937 PAS fold; Region: PAS_4; pfam08448 756272008938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272008939 putative active site [active] 756272008940 heme pocket [chemical binding]; other site 756272008941 Helix-turn-helix domain; Region: HTH_18; pfam12833 756272008942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272008943 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 756272008944 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 756272008945 OPT oligopeptide transporter protein; Region: OPT; pfam03169 756272008946 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 756272008947 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 756272008948 FMN binding site [chemical binding]; other site 756272008949 active site 756272008950 substrate binding site [chemical binding]; other site 756272008951 catalytic residue [active] 756272008952 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 756272008953 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 756272008954 putative NAD(P) binding site [chemical binding]; other site 756272008955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 756272008956 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 756272008957 hypothetical protein; Provisional; Region: PRK05409 756272008958 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 756272008959 nucleoside/Zn binding site; other site 756272008960 dimer interface [polypeptide binding]; other site 756272008961 catalytic motif [active] 756272008962 Peptidase family M41; Region: Peptidase_M41; pfam01434 756272008963 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 756272008964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 756272008965 ATP-dependent DNA ligase; Validated; Region: PRK09247 756272008966 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 756272008967 active site 756272008968 DNA binding site [nucleotide binding] 756272008969 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 756272008970 DNA binding site [nucleotide binding] 756272008971 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 756272008972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272008973 ATP binding site [chemical binding]; other site 756272008974 putative Mg++ binding site [ion binding]; other site 756272008975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272008976 nucleotide binding region [chemical binding]; other site 756272008977 ATP-binding site [chemical binding]; other site 756272008978 DEAD/H associated; Region: DEAD_assoc; pfam08494 756272008979 metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123 756272008980 active site 756272008981 metal binding site [ion binding]; metal-binding site 756272008982 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 756272008983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272008984 active site 756272008985 phosphorylation site [posttranslational modification] 756272008986 intermolecular recognition site; other site 756272008987 dimerization interface [polypeptide binding]; other site 756272008988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272008989 Zn2+ binding site [ion binding]; other site 756272008990 Mg2+ binding site [ion binding]; other site 756272008991 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 756272008992 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 756272008993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272008994 putative active site [active] 756272008995 heme pocket [chemical binding]; other site 756272008996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272008997 dimer interface [polypeptide binding]; other site 756272008998 phosphorylation site [posttranslational modification] 756272008999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272009000 ATP binding site [chemical binding]; other site 756272009001 Mg2+ binding site [ion binding]; other site 756272009002 G-X-G motif; other site 756272009003 Response regulator receiver domain; Region: Response_reg; pfam00072 756272009004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272009005 active site 756272009006 phosphorylation site [posttranslational modification] 756272009007 intermolecular recognition site; other site 756272009008 dimerization interface [polypeptide binding]; other site 756272009009 Response regulator receiver domain; Region: Response_reg; pfam00072 756272009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272009011 active site 756272009012 phosphorylation site [posttranslational modification] 756272009013 intermolecular recognition site; other site 756272009014 dimerization interface [polypeptide binding]; other site 756272009015 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 756272009016 putative binding surface; other site 756272009017 active site 756272009018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272009019 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272009021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272009022 Walker A/P-loop; other site 756272009023 ATP binding site [chemical binding]; other site 756272009024 Q-loop/lid; other site 756272009025 ABC transporter signature motif; other site 756272009026 Walker B; other site 756272009027 D-loop; other site 756272009028 H-loop/switch region; other site 756272009029 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272009030 FtsX-like permease family; Region: FtsX; pfam02687 756272009031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 756272009032 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 756272009033 P-loop containing region of AAA domain; Region: AAA_29; cl17516 756272009034 AAA domain; Region: AAA_27; pfam13514 756272009035 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 756272009036 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 756272009037 active site 756272009038 metal binding site [ion binding]; metal-binding site 756272009039 DNA binding site [nucleotide binding] 756272009040 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 756272009041 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009042 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 756272009043 Protein export membrane protein; Region: SecD_SecF; cl14618 756272009044 NHL repeat; Region: NHL; pfam01436 756272009045 NHL repeat; Region: NHL; pfam01436 756272009046 Family description; Region: VCBS; pfam13517 756272009047 Family description; Region: VCBS; pfam13517 756272009048 Family description; Region: VCBS; pfam13517 756272009049 Family description; Region: VCBS; pfam13517 756272009050 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 756272009051 acid-resistance membrane protein; Provisional; Region: PRK10209 756272009052 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272009053 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272009054 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 756272009055 Ligand Binding Site [chemical binding]; other site 756272009056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 756272009057 PAS domain; Region: PAS_9; pfam13426 756272009058 putative active site [active] 756272009059 heme pocket [chemical binding]; other site 756272009060 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 756272009061 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272009062 purine nucleoside phosphorylase; Provisional; Region: PRK08202 756272009063 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 756272009064 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009065 Sulfatase; Region: Sulfatase; pfam00884 756272009066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 756272009067 Cupin-like domain; Region: Cupin_8; pfam13621 756272009068 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 756272009069 23S rRNA interface [nucleotide binding]; other site 756272009070 L3 interface [polypeptide binding]; other site 756272009071 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 756272009072 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 756272009073 MgtE intracellular N domain; Region: MgtE_N; pfam03448 756272009074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 756272009075 Divalent cation transporter; Region: MgtE; cl00786 756272009076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 756272009077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 756272009078 dimerization interface [polypeptide binding]; other site 756272009079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272009080 putative active site [active] 756272009081 heme pocket [chemical binding]; other site 756272009082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272009083 dimer interface [polypeptide binding]; other site 756272009084 phosphorylation site [posttranslational modification] 756272009085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272009086 ATP binding site [chemical binding]; other site 756272009087 Mg2+ binding site [ion binding]; other site 756272009088 G-X-G motif; other site 756272009089 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272009090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272009091 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 756272009092 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 756272009093 putative ligand binding site [chemical binding]; other site 756272009094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 756272009095 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 756272009096 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272009097 active site 756272009098 catalytic residues [active] 756272009099 DNA binding site [nucleotide binding] 756272009100 Int/Topo IB signature motif; other site 756272009101 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 756272009102 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 756272009103 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 756272009104 active site 756272009105 metal binding site [ion binding]; metal-binding site 756272009106 interdomain interaction site; other site 756272009107 D5 N terminal like; Region: D5_N; pfam08706 756272009108 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 756272009109 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272009110 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 756272009111 classical (c) SDRs; Region: SDR_c; cd05233 756272009112 NAD(P) binding site [chemical binding]; other site 756272009113 active site 756272009114 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272009115 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272009116 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 756272009117 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272009118 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272009119 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272009120 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272009121 structural tetrad; other site 756272009122 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272009123 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272009124 structural tetrad; other site 756272009125 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 756272009126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272009127 AAA domain; Region: AAA_26; pfam13500 756272009128 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 756272009129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 756272009130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 756272009131 active site 756272009132 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 756272009133 adenylate kinase; Reviewed; Region: adk; PRK00279 756272009134 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 756272009135 AMP-binding site [chemical binding]; other site 756272009136 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 756272009137 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 756272009138 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 756272009139 active site 756272009140 catalytic residue [active] 756272009141 dimer interface [polypeptide binding]; other site 756272009142 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 756272009143 NAD(P) binding site [chemical binding]; other site 756272009144 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 756272009145 EamA-like transporter family; Region: EamA; pfam00892 756272009146 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 756272009147 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 756272009148 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 756272009149 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 756272009150 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272009151 metal ion-dependent adhesion site (MIDAS); other site 756272009152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009153 binding surface 756272009154 TPR motif; other site 756272009155 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 756272009156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272009157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272009158 DNA binding residues [nucleotide binding] 756272009159 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 756272009160 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 756272009161 oligomerisation interface [polypeptide binding]; other site 756272009162 mobile loop; other site 756272009163 roof hairpin; other site 756272009164 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 756272009165 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 756272009166 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272009167 active site 756272009168 catalytic residues [active] 756272009169 DNA binding site [nucleotide binding] 756272009170 Int/Topo IB signature motif; other site 756272009171 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272009172 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 756272009173 Sel1 repeat; Region: Sel1; pfam08238 756272009174 Sel1-like repeats; Region: SEL1; smart00671 756272009175 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 756272009176 Helix-turn-helix domain; Region: HTH_38; pfam13936 756272009177 Integrase core domain; Region: rve; pfam00665 756272009178 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 756272009179 HEAT repeats; Region: HEAT_2; pfam13646 756272009180 protein binding surface [polypeptide binding]; other site 756272009181 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 756272009182 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 756272009183 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 756272009184 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 756272009185 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 756272009186 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 756272009187 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 756272009188 active site 756272009189 zinc binding site [ion binding]; other site 756272009190 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 756272009191 Caspase domain; Region: Peptidase_C14; pfam00656 756272009192 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272009193 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272009194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009196 binding surface 756272009197 TPR motif; other site 756272009198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009202 binding surface 756272009203 TPR motif; other site 756272009204 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009205 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 756272009206 protein binding site [polypeptide binding]; other site 756272009207 CHAT domain; Region: CHAT; pfam12770 756272009208 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272009209 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 756272009210 Caspase domain; Region: Peptidase_C14; pfam00656 756272009211 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 756272009212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009214 binding surface 756272009215 TPR motif; other site 756272009216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009217 TPR motif; other site 756272009218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009219 binding surface 756272009220 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009221 CHAT domain; Region: CHAT; pfam12770 756272009222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009226 binding surface 756272009227 TPR motif; other site 756272009228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272009231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009232 TPR motif; other site 756272009233 binding surface 756272009234 CHAT domain; Region: CHAT; cl17868 756272009235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009236 CHAT domain; Region: CHAT; pfam12770 756272009237 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 756272009238 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272009239 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009240 protein binding site [polypeptide binding]; other site 756272009241 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009242 ThiF family; Region: ThiF; pfam00899 756272009243 ATP binding site [chemical binding]; other site 756272009244 Ubiquitin-like proteins; Region: UBQ; cl00155 756272009245 charged pocket; other site 756272009246 hydrophobic patch; other site 756272009247 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 756272009248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272009249 non-specific DNA binding site [nucleotide binding]; other site 756272009250 salt bridge; other site 756272009251 sequence-specific DNA binding site [nucleotide binding]; other site 756272009252 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 756272009253 catalytic residues [active] 756272009254 catalytic nucleophile [active] 756272009255 Recombinase; Region: Recombinase; pfam07508 756272009256 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272009257 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009258 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272009259 HEAT repeats; Region: HEAT_2; pfam13646 756272009260 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272009261 Cytochrome c; Region: Cytochrom_C; pfam00034 756272009262 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 756272009263 proposed catalytic triad [active] 756272009264 active site nucleophile [active] 756272009265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272009266 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 756272009267 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 756272009268 Zn binding site [ion binding]; other site 756272009269 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 756272009270 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272009271 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009272 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 756272009273 reactive center loop; other site 756272009274 Caspase domain; Region: Peptidase_C14; pfam00656 756272009275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272009276 protein binding site [polypeptide binding]; other site 756272009277 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 756272009278 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272009279 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 756272009280 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 756272009281 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 756272009282 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 756272009283 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 756272009284 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272009285 Sulfatase; Region: Sulfatase; cl17466 756272009286 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272009287 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272009288 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272009289 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272009290 active site 756272009291 PQQ-like domain; Region: PQQ_2; pfam13360 756272009292 Trp docking motif [polypeptide binding]; other site 756272009293 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 756272009294 Ca2+ binding site [ion binding]; other site 756272009295 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009296 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009297 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 756272009298 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 756272009299 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 756272009300 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 756272009301 active site 756272009302 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009303 Sulfatase; Region: Sulfatase; pfam00884 756272009304 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009305 Sulfatase; Region: Sulfatase; pfam00884 756272009306 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 756272009307 active site 756272009308 catalytic residues [active] 756272009309 putative transporter; Provisional; Region: PRK10484 756272009310 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 756272009311 Na binding site [ion binding]; other site 756272009312 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 756272009313 classical (c) SDRs; Region: SDR_c; cd05233 756272009314 NAD(P) binding site [chemical binding]; other site 756272009315 active site 756272009316 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009317 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 756272009318 putative dimerization interface [polypeptide binding]; other site 756272009319 putative ligand binding site [chemical binding]; other site 756272009320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272009321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272009323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009324 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 756272009325 putative dimerization interface [polypeptide binding]; other site 756272009326 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 756272009327 putative ligand binding site [chemical binding]; other site 756272009328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272009330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009331 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 756272009332 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272009333 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272009334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272009335 Family description; Region: VCBS; pfam13517 756272009336 Family description; Region: VCBS; pfam13517 756272009337 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 756272009338 Uncharacterized conserved protein [Function unknown]; Region: COG1262 756272009339 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 756272009340 haloalkane dehalogenase; Provisional; Region: PRK00870 756272009341 EF hand; Region: EF_hand_3; pfam13202 756272009342 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 756272009343 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272009344 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 756272009345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272009346 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 756272009347 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272009348 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272009349 substrate binding pocket [chemical binding]; other site 756272009350 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009351 Sulfatase; Region: Sulfatase; pfam00884 756272009352 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 756272009353 Ca2+ binding site [ion binding]; other site 756272009354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272009355 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272009356 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272009357 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 756272009358 Ca2+ binding site [ion binding]; other site 756272009359 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 756272009360 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272009361 putative catalytic residue [active] 756272009362 Haem-binding domain; Region: Haem_bd; pfam14376 756272009363 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 756272009364 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 756272009365 EF-hand domain pair; Region: EF_hand_5; pfam13499 756272009366 Ca2+ binding site [ion binding]; other site 756272009367 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272009368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272009369 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272009370 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 756272009371 ATP binding site [chemical binding]; other site 756272009372 AAA-like domain; Region: AAA_10; pfam12846 756272009373 Ubiquitin-like proteins; Region: UBQ; cl00155 756272009374 charged pocket; other site 756272009375 hydrophobic patch; other site 756272009376 Ycf46; Provisional; Region: ycf46; CHL00195 756272009377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272009378 Walker A motif; other site 756272009379 ATP binding site [chemical binding]; other site 756272009380 Walker B motif; other site 756272009381 arginine finger; other site 756272009382 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 756272009383 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 756272009384 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272009385 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 756272009386 catalytic residues [active] 756272009387 catalytic nucleophile [active] 756272009388 Recombinase; Region: Recombinase; pfam07508 756272009389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 756272009390 Helix-turn-helix domain; Region: HTH_17; cl17695 756272009391 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 756272009392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 756272009393 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 756272009394 active site 756272009395 catalytic residues [active] 756272009396 DNA binding site [nucleotide binding] 756272009397 Int/Topo IB signature motif; other site 756272009398 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009399 Sulfatase; Region: Sulfatase; pfam00884 756272009400 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009401 Sulfatase; Region: Sulfatase; pfam00884 756272009402 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 756272009403 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 756272009404 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 756272009405 Peptidase family M50; Region: Peptidase_M50; pfam02163 756272009406 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 756272009407 active site 756272009408 putative substrate binding region [chemical binding]; other site 756272009409 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272009410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272009411 GAF domain; Region: GAF; pfam01590 756272009412 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272009413 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009414 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 756272009415 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 756272009416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 756272009417 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272009418 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009419 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 756272009420 Ligand Binding Site [chemical binding]; other site 756272009421 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 756272009422 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 756272009423 cobalamin binding residues [chemical binding]; other site 756272009424 putative BtuC binding residues; other site 756272009425 dimer interface [polypeptide binding]; other site 756272009426 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 756272009427 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 756272009428 metal binding site [ion binding]; metal-binding site 756272009429 active site 756272009430 I-site; other site 756272009431 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 756272009432 putative heme binding site [chemical binding]; other site 756272009433 putative substrate binding site [chemical binding]; other site 756272009434 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 756272009435 amino acid transporter; Region: 2A0306; TIGR00909 756272009436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 756272009437 MOSC domain; Region: MOSC; pfam03473 756272009438 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 756272009439 AMP binding site [chemical binding]; other site 756272009440 metal binding site [ion binding]; metal-binding site 756272009441 active site 756272009442 transketolase; Reviewed; Region: PRK05899 756272009443 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 756272009444 TPP-binding site [chemical binding]; other site 756272009445 dimer interface [polypeptide binding]; other site 756272009446 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 756272009447 PYR/PP interface [polypeptide binding]; other site 756272009448 dimer interface [polypeptide binding]; other site 756272009449 TPP binding site [chemical binding]; other site 756272009450 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 756272009451 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 756272009452 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 756272009453 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 756272009454 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 756272009455 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 756272009456 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 756272009457 active site 756272009458 DNA binding site [nucleotide binding] 756272009459 Int/Topo IB signature motif; other site 756272009460 catalytic residues [active] 756272009461 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 756272009462 nucleotide binding site/active site [active] 756272009463 HIT family signature motif; other site 756272009464 catalytic residue [active] 756272009465 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272009466 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 756272009467 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 756272009468 active site 756272009469 cosubstrate binding site; other site 756272009470 substrate binding site [chemical binding]; other site 756272009471 catalytic site [active] 756272009472 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 756272009473 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 756272009474 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272009475 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272009476 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 756272009477 catalytic residues [active] 756272009478 catalytic nucleophile [active] 756272009479 Presynaptic Site I dimer interface [polypeptide binding]; other site 756272009480 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 756272009481 Synaptic Flat tetramer interface [polypeptide binding]; other site 756272009482 Synaptic Site I dimer interface [polypeptide binding]; other site 756272009483 DNA binding site [nucleotide binding] 756272009484 Recombinase; Region: Recombinase; pfam07508 756272009485 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272009486 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272009487 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272009488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 756272009489 DNA-binding site [nucleotide binding]; DNA binding site 756272009490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272009491 non-specific DNA binding site [nucleotide binding]; other site 756272009492 salt bridge; other site 756272009493 sequence-specific DNA binding site [nucleotide binding]; other site 756272009494 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 756272009495 Ubiquitin-like proteins; Region: UBQ; cl00155 756272009496 charged pocket; other site 756272009497 hydrophobic patch; other site 756272009498 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 756272009499 ThiF family; Region: ThiF; pfam00899 756272009500 ATP binding site [chemical binding]; other site 756272009501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272009502 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 756272009503 active site 1 [active] 756272009504 dimer interface [polypeptide binding]; other site 756272009505 hexamer interface [polypeptide binding]; other site 756272009506 active site 2 [active] 756272009507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 756272009508 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 756272009509 NADP binding site [chemical binding]; other site 756272009510 substrate binding site [chemical binding]; other site 756272009511 active site 756272009512 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 756272009513 Helix-turn-helix domain; Region: HTH_18; pfam12833 756272009514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009515 Uncharacterized conserved protein [Function unknown]; Region: COG5361 756272009516 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 756272009517 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 756272009518 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009519 Sulfatase; Region: Sulfatase; pfam00884 756272009520 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 756272009521 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009522 Sulfatase; Region: Sulfatase; pfam00884 756272009523 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272009524 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009525 Sulfatase; Region: Sulfatase; pfam00884 756272009526 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009527 Sulfatase; Region: Sulfatase; pfam00884 756272009528 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272009529 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 756272009530 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 756272009531 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 756272009532 HNH endonuclease; Region: HNH; pfam01844 756272009533 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 756272009534 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 756272009535 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 756272009536 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 756272009537 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 756272009538 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 756272009539 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 756272009540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 756272009541 DDE superfamily endonuclease; Region: DDE_3; pfam13358 756272009542 hypothetical protein; Validated; Region: PRK07668 756272009543 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 756272009544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 756272009545 motif II; other site 756272009546 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 756272009547 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 756272009548 putative active site [active] 756272009549 metal binding site [ion binding]; metal-binding site 756272009550 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 756272009551 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 756272009552 putative active site [active] 756272009553 putative metal binding site [ion binding]; other site 756272009554 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 756272009555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272009556 non-specific DNA binding site [nucleotide binding]; other site 756272009557 salt bridge; other site 756272009558 sequence-specific DNA binding site [nucleotide binding]; other site 756272009559 Cupin domain; Region: Cupin_2; pfam07883 756272009560 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 756272009561 hydroxyglutarate oxidase; Provisional; Region: PRK11728 756272009562 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 756272009563 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272009564 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272009565 Trp docking motif [polypeptide binding]; other site 756272009566 active site 756272009567 PQQ-like domain; Region: PQQ_2; pfam13360 756272009568 Sulfatase; Region: Sulfatase; cl17466 756272009569 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009570 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272009571 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272009572 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272009573 PQQ-like domain; Region: PQQ_2; pfam13360 756272009574 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272009575 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272009576 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 756272009577 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 756272009578 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272009579 Penicillinase repressor; Region: Pencillinase_R; pfam03965 756272009580 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009581 Sulfatase; Region: Sulfatase; cl17466 756272009582 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009583 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 756272009584 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 756272009585 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 756272009586 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009587 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 756272009588 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 756272009589 putative NAD(P) binding site [chemical binding]; other site 756272009590 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 756272009591 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 756272009592 dimer interface [polypeptide binding]; other site 756272009593 active site 756272009594 heme binding site [chemical binding]; other site 756272009595 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 756272009596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 756272009597 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 756272009598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 756272009599 ligand binding site [chemical binding]; other site 756272009600 flexible hinge region; other site 756272009601 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 756272009602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 756272009603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272009604 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 756272009605 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272009606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272009607 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 756272009608 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272009609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272009610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272009611 DNA binding residues [nucleotide binding] 756272009612 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 756272009613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 756272009614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272009615 active site 756272009616 phosphorylation site [posttranslational modification] 756272009617 intermolecular recognition site; other site 756272009618 dimerization interface [polypeptide binding]; other site 756272009619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 756272009620 DNA binding site [nucleotide binding] 756272009621 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 756272009622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 756272009623 dimerization interface [polypeptide binding]; other site 756272009624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272009625 dimer interface [polypeptide binding]; other site 756272009626 phosphorylation site [posttranslational modification] 756272009627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272009628 ATP binding site [chemical binding]; other site 756272009629 Mg2+ binding site [ion binding]; other site 756272009630 G-X-G motif; other site 756272009631 Outer membrane efflux protein; Region: OEP; pfam02321 756272009632 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272009633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272009634 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009635 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 756272009636 Protein export membrane protein; Region: SecD_SecF; cl14618 756272009637 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272009638 NPCBM/NEW2 domain; Region: NPCBM; cl07060 756272009639 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272009640 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009641 Sulfatase; Region: Sulfatase; pfam00884 756272009642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 756272009643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272009644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272009645 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272009646 active site 756272009647 catalytic triad [active] 756272009648 oxyanion hole [active] 756272009649 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272009650 HEAT repeats; Region: HEAT_2; pfam13646 756272009651 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 756272009652 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 756272009653 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272009654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272009655 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272009656 active site 756272009657 catalytic tetrad [active] 756272009658 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 756272009659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 756272009660 putative NAD(P) binding site [chemical binding]; other site 756272009661 catalytic Zn binding site [ion binding]; other site 756272009662 structural Zn binding site [ion binding]; other site 756272009663 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272009664 D-mannonate oxidoreductase; Provisional; Region: PRK08277 756272009665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272009666 NAD(P) binding site [chemical binding]; other site 756272009667 active site 756272009668 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 756272009669 Amidohydrolase; Region: Amidohydro_2; pfam04909 756272009670 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272009671 Sulfatase; Region: Sulfatase; cl17466 756272009672 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272009674 FG-GAP repeat; Region: FG-GAP; pfam01839 756272009675 Family description; Region: VCBS; pfam13517 756272009676 Family description; Region: VCBS; pfam13517 756272009677 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009678 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009679 Sulfatase; Region: Sulfatase; pfam00884 756272009680 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009681 Sulfatase; Region: Sulfatase; pfam00884 756272009682 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009683 Sulfatase; Region: Sulfatase; cl17466 756272009684 Sulfatase; Region: Sulfatase; cl17466 756272009685 Cupin domain; Region: Cupin_2; pfam07883 756272009686 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 756272009687 Uncharacterized conserved protein [Function unknown]; Region: COG2128 756272009688 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 756272009689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 756272009690 DNA-binding site [nucleotide binding]; DNA binding site 756272009691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272009692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272009693 homodimer interface [polypeptide binding]; other site 756272009694 catalytic residue [active] 756272009695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 756272009696 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272009697 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272009698 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 756272009699 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 756272009700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272009701 Walker A motif; other site 756272009702 ATP binding site [chemical binding]; other site 756272009703 Walker B motif; other site 756272009704 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 756272009705 Cupin domain; Region: Cupin_2; pfam07883 756272009706 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 756272009707 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 756272009708 catalytic site [active] 756272009709 BNR repeat-like domain; Region: BNR_2; pfam13088 756272009710 Asp-box motif; other site 756272009711 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 756272009712 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 756272009713 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 756272009714 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272009715 catalytic residues [active] 756272009716 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 756272009717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272009718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 756272009719 Predicted integral membrane protein [Function unknown]; Region: COG5660 756272009720 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272009721 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272009722 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272009723 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 756272009724 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 756272009725 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 756272009726 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 756272009727 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 756272009728 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 756272009729 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 756272009730 Tetramer interface [polypeptide binding]; other site 756272009731 active site 756272009732 FMN-binding site [chemical binding]; other site 756272009733 aspartate aminotransferase; Provisional; Region: PRK05764 756272009734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272009735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272009736 homodimer interface [polypeptide binding]; other site 756272009737 catalytic residue [active] 756272009738 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 756272009739 MoaE homodimer interface [polypeptide binding]; other site 756272009740 MoaD interaction [polypeptide binding]; other site 756272009741 active site residues [active] 756272009742 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 756272009743 MoaE interaction surface [polypeptide binding]; other site 756272009744 MoeB interaction surface [polypeptide binding]; other site 756272009745 thiocarboxylated glycine; other site 756272009746 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 756272009747 FAD binding domain; Region: FAD_binding_4; pfam01565 756272009748 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 756272009749 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 756272009750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272009751 ATP binding site [chemical binding]; other site 756272009752 putative Mg++ binding site [ion binding]; other site 756272009753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272009754 nucleotide binding region [chemical binding]; other site 756272009755 ATP-binding site [chemical binding]; other site 756272009756 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 756272009757 HRDC domain; Region: HRDC; pfam00570 756272009758 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 756272009759 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 756272009760 putative active site [active] 756272009761 catalytic triad [active] 756272009762 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272009763 Methyltransferase domain; Region: Methyltransf_11; pfam08241 756272009764 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272009765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272009766 S-adenosylmethionine binding site [chemical binding]; other site 756272009767 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272009768 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 756272009769 putative metal binding site; other site 756272009770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 756272009771 Methyltransferase domain; Region: Methyltransf_24; pfam13578 756272009772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272009773 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272009774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272009775 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272009776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272009777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272009778 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 756272009779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 756272009780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272009781 Walker A/P-loop; other site 756272009782 ATP binding site [chemical binding]; other site 756272009783 Q-loop/lid; other site 756272009784 ABC transporter signature motif; other site 756272009785 Walker B; other site 756272009786 D-loop; other site 756272009787 H-loop/switch region; other site 756272009788 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272009789 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272009790 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272009791 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272009792 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 756272009793 Domain of unknown function (DUF329); Region: DUF329; cl01144 756272009794 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 756272009795 GrpE; Region: GrpE; pfam01025 756272009796 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 756272009797 dimer interface [polypeptide binding]; other site 756272009798 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 756272009799 chaperone protein DnaJ; Provisional; Region: PRK10767 756272009800 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 756272009801 HSP70 interaction site [polypeptide binding]; other site 756272009802 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 756272009803 Zn binding sites [ion binding]; other site 756272009804 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 756272009805 dimer interface [polypeptide binding]; other site 756272009806 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 756272009807 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 756272009808 ring oligomerisation interface [polypeptide binding]; other site 756272009809 ATP/Mg binding site [chemical binding]; other site 756272009810 stacking interactions; other site 756272009811 hinge regions; other site 756272009812 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 756272009813 oligomerisation interface [polypeptide binding]; other site 756272009814 mobile loop; other site 756272009815 roof hairpin; other site 756272009816 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 756272009817 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 756272009818 ring oligomerisation interface [polypeptide binding]; other site 756272009819 ATP/Mg binding site [chemical binding]; other site 756272009820 stacking interactions; other site 756272009821 hinge regions; other site 756272009822 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 756272009823 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 756272009824 Sulfatase; Region: Sulfatase; cl17466 756272009825 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272009826 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 756272009827 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 756272009828 ring oligomerisation interface [polypeptide binding]; other site 756272009829 ATP/Mg binding site [chemical binding]; other site 756272009830 stacking interactions; other site 756272009831 hinge regions; other site 756272009832 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 756272009833 oligomerisation interface [polypeptide binding]; other site 756272009834 mobile loop; other site 756272009835 roof hairpin; other site 756272009836 RF-1 domain; Region: RF-1; pfam00472 756272009837 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 756272009838 hypothetical protein; Provisional; Region: PRK04194 756272009839 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 756272009840 tartrate dehydrogenase; Region: TTC; TIGR02089 756272009841 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 756272009842 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 756272009843 DXD motif; other site 756272009844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272009845 S-adenosylmethionine binding site [chemical binding]; other site 756272009846 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 756272009847 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 756272009848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272009849 Coenzyme A binding pocket [chemical binding]; other site 756272009850 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272009851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009852 binding surface 756272009853 TPR repeat; Region: TPR_11; pfam13414 756272009854 TPR motif; other site 756272009855 TPR repeat; Region: TPR_11; pfam13414 756272009856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272009857 binding surface 756272009858 TPR motif; other site 756272009859 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 756272009860 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 756272009861 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 756272009862 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 756272009863 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 756272009864 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272009865 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272009866 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 756272009867 Sodium Bile acid symporter family; Region: SBF; cl17470 756272009868 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 756272009869 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 756272009870 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 756272009871 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 756272009872 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 756272009873 putative dimer interface [polypeptide binding]; other site 756272009874 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 756272009875 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 756272009876 putative dimer interface [polypeptide binding]; other site 756272009877 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 756272009878 dimer interface [polypeptide binding]; other site 756272009879 allosteric magnesium binding site [ion binding]; other site 756272009880 active site 756272009881 aspartate-rich active site metal binding site; other site 756272009882 Schiff base residues; other site 756272009883 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 756272009884 metal binding triad; other site 756272009885 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 756272009886 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272009887 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272009888 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 756272009889 metal binding triad; other site 756272009890 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 756272009891 RNA methyltransferase, RsmE family; Region: TIGR00046 756272009892 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 756272009893 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 756272009894 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 756272009895 Domain of unknown function DUF20; Region: UPF0118; pfam01594 756272009896 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 756272009897 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 756272009898 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 756272009899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272009900 active site 756272009901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 756272009902 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 756272009903 catalytic residue [active] 756272009904 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 756272009905 RNA binding site [nucleotide binding]; other site 756272009906 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 756272009907 RNA binding site [nucleotide binding]; other site 756272009908 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 756272009909 RNA binding site [nucleotide binding]; other site 756272009910 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 756272009911 RNA binding site [nucleotide binding]; other site 756272009912 domain interface; other site 756272009913 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 756272009914 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 756272009915 minor groove reading motif; other site 756272009916 helix-hairpin-helix signature motif; other site 756272009917 substrate binding pocket [chemical binding]; other site 756272009918 active site 756272009919 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 756272009920 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 756272009921 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 756272009922 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 756272009923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272009924 catalytic residues [active] 756272009925 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 756272009926 ThiS interaction site; other site 756272009927 putative active site [active] 756272009928 tetramer interface [polypeptide binding]; other site 756272009929 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 756272009930 thiS-thiF/thiG interaction site; other site 756272009931 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 756272009932 TrkA-N domain; Region: TrkA_N; pfam02254 756272009933 TrkA-C domain; Region: TrkA_C; pfam02080 756272009934 TrkA-N domain; Region: TrkA_N; pfam02254 756272009935 TrkA-C domain; Region: TrkA_C; pfam02080 756272009936 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 756272009937 active site 756272009938 DinB superfamily; Region: DinB_2; pfam12867 756272009939 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272009940 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272009941 Peptidase C26; Region: Peptidase_C26; pfam07722 756272009942 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 756272009943 catalytic triad [active] 756272009944 GAF domain; Region: GAF; cl17456 756272009945 Outer membrane efflux protein; Region: OEP; pfam02321 756272009946 Outer membrane efflux protein; Region: OEP; pfam02321 756272009947 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 756272009948 nucleotide binding site/active site [active] 756272009949 HIT family signature motif; other site 756272009950 catalytic residue [active] 756272009951 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272009952 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 756272009953 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 756272009954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272009955 putative active site [active] 756272009956 heme pocket [chemical binding]; other site 756272009957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272009958 dimer interface [polypeptide binding]; other site 756272009959 phosphorylation site [posttranslational modification] 756272009960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272009961 ATP binding site [chemical binding]; other site 756272009962 Mg2+ binding site [ion binding]; other site 756272009963 G-X-G motif; other site 756272009964 YTV; Region: YTV; pfam07639 756272009965 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 756272009966 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 756272009967 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 756272009968 active site 756272009969 substrate binding site [chemical binding]; other site 756272009970 metal binding site [ion binding]; metal-binding site 756272009971 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272009972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272009973 active site 756272009974 ATP binding site [chemical binding]; other site 756272009975 substrate binding site [chemical binding]; other site 756272009976 activation loop (A-loop); other site 756272009977 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272009978 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272009979 structural tetrad; other site 756272009980 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272009981 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272009982 structural tetrad; other site 756272009983 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272009984 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272009985 structural tetrad; other site 756272009986 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 756272009987 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 756272009988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272009989 active site 756272009990 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272009991 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272009992 phosphopeptide binding site; other site 756272009993 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 756272009994 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 756272009995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272009996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272009997 ATP binding site [chemical binding]; other site 756272009998 Mg2+ binding site [ion binding]; other site 756272009999 G-X-G motif; other site 756272010000 DNA polymerase IV; Reviewed; Region: PRK03103 756272010001 Y-family of DNA polymerases; Region: PolY; cd00424 756272010002 active site 756272010003 DNA binding site [nucleotide binding] 756272010004 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 756272010005 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 756272010006 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 756272010007 homodimer interface [polypeptide binding]; other site 756272010008 oligonucleotide binding site [chemical binding]; other site 756272010009 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 756272010010 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010011 Sulfatase; Region: Sulfatase; pfam00884 756272010012 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 756272010013 Cell division protein FtsA; Region: FtsA; pfam14450 756272010014 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 756272010015 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 756272010016 thiamine phosphate binding site [chemical binding]; other site 756272010017 active site 756272010018 pyrophosphate binding site [ion binding]; other site 756272010019 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272010020 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272010021 active site residue [active] 756272010022 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272010023 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 756272010024 FOG: WD40 repeat [General function prediction only]; Region: COG2319 756272010025 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 756272010026 structural tetrad; other site 756272010027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 756272010028 MarR family; Region: MarR_2; pfam12802 756272010029 Predicted membrane protein [Function unknown]; Region: COG3463 756272010030 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 756272010031 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 756272010032 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 756272010033 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 756272010034 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 756272010035 Propanediol utilisation protein PduL; Region: PduL; pfam06130 756272010036 Propanediol utilisation protein PduL; Region: PduL; pfam06130 756272010037 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 756272010038 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 756272010039 Hexamer interface [polypeptide binding]; other site 756272010040 Hexagonal pore residue; other site 756272010041 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 756272010042 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 756272010043 Hexamer interface [polypeptide binding]; other site 756272010044 Hexagonal pore residue; other site 756272010045 Acetokinase family; Region: Acetate_kinase; cl17229 756272010046 propionate/acetate kinase; Provisional; Region: PRK12379 756272010047 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 756272010048 Hexamer/Pentamer interface [polypeptide binding]; other site 756272010049 central pore; other site 756272010050 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 756272010051 putative catalytic cysteine [active] 756272010052 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 756272010053 four helix bundle protein; Region: TIGR02436 756272010054 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 756272010055 Hexamer/Pentamer interface [polypeptide binding]; other site 756272010056 central pore; other site 756272010057 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 756272010058 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 756272010059 Hexamer/Pentamer interface [polypeptide binding]; other site 756272010060 central pore; other site 756272010061 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 756272010062 intersubunit interface [polypeptide binding]; other site 756272010063 active site 756272010064 Zn2+ binding site [ion binding]; other site 756272010065 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272010066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272010067 Walker A motif; other site 756272010068 ATP binding site [chemical binding]; other site 756272010069 Walker B motif; other site 756272010070 arginine finger; other site 756272010071 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 756272010072 putative ligand binding site [chemical binding]; other site 756272010073 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 756272010074 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 756272010075 dimer interface [polypeptide binding]; other site 756272010076 active site 756272010077 CoA binding pocket [chemical binding]; other site 756272010078 Pantoate-beta-alanine ligase; Region: PanC; cd00560 756272010079 pantoate--beta-alanine ligase; Region: panC; TIGR00018 756272010080 active site 756272010081 ATP-binding site [chemical binding]; other site 756272010082 pantoate-binding site; other site 756272010083 HXXH motif; other site 756272010084 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 756272010085 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 756272010086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272010087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272010088 DNA binding residues [nucleotide binding] 756272010089 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 756272010090 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 756272010091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 756272010092 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010093 Sulfatase; Region: Sulfatase; pfam00884 756272010094 PQQ-like domain; Region: PQQ_2; pfam13360 756272010095 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272010096 active site 756272010097 Trp docking motif [polypeptide binding]; other site 756272010098 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 756272010099 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272010100 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 756272010101 catalytic residues [active] 756272010102 catalytic nucleophile [active] 756272010103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 756272010104 non-specific DNA binding site [nucleotide binding]; other site 756272010105 salt bridge; other site 756272010106 sequence-specific DNA binding site [nucleotide binding]; other site 756272010107 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 756272010108 Ubiquitin-like proteins; Region: UBQ; cl00155 756272010109 charged pocket; other site 756272010110 hydrophobic patch; other site 756272010111 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 756272010112 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 756272010113 ATP binding site [chemical binding]; other site 756272010114 substrate interface [chemical binding]; other site 756272010115 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 756272010116 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 756272010117 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 756272010118 HNH endonuclease; Region: HNH; pfam01844 756272010119 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 756272010120 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 756272010121 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 756272010122 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 756272010123 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 756272010124 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 756272010125 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 756272010126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 756272010127 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272010128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272010129 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272010130 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010131 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 756272010132 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 756272010133 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 756272010134 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 756272010135 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 756272010136 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 756272010137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 756272010138 G1 box; other site 756272010139 GTP/Mg2+ binding site [chemical binding]; other site 756272010140 G2 box; other site 756272010141 Switch I region; other site 756272010142 G3 box; other site 756272010143 Switch II region; other site 756272010144 G4 box; other site 756272010145 G5 box; other site 756272010146 Nucleoside recognition; Region: Gate; pfam07670 756272010147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 756272010148 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 756272010149 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 756272010150 Walker A/P-loop; other site 756272010151 ATP binding site [chemical binding]; other site 756272010152 Q-loop/lid; other site 756272010153 ABC transporter signature motif; other site 756272010154 Walker B; other site 756272010155 D-loop; other site 756272010156 H-loop/switch region; other site 756272010157 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 756272010158 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 756272010159 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 756272010160 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 756272010161 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 756272010162 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010163 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272010164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272010165 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272010166 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 756272010167 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 756272010168 CAAX protease self-immunity; Region: Abi; pfam02517 756272010169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272010170 dimerization interface [polypeptide binding]; other site 756272010171 putative DNA binding site [nucleotide binding]; other site 756272010172 putative Zn2+ binding site [ion binding]; other site 756272010173 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 756272010174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 756272010175 active site residue [active] 756272010176 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 756272010177 active site residue [active] 756272010178 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 756272010179 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 756272010180 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 756272010181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272010182 dimer interface [polypeptide binding]; other site 756272010183 conserved gate region; other site 756272010184 putative PBP binding loops; other site 756272010185 ABC-ATPase subunit interface; other site 756272010186 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 756272010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272010188 dimer interface [polypeptide binding]; other site 756272010189 conserved gate region; other site 756272010190 putative PBP binding loops; other site 756272010191 ABC-ATPase subunit interface; other site 756272010192 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 756272010193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 756272010194 Walker A/P-loop; other site 756272010195 ATP binding site [chemical binding]; other site 756272010196 Q-loop/lid; other site 756272010197 ABC transporter signature motif; other site 756272010198 Walker B; other site 756272010199 D-loop; other site 756272010200 H-loop/switch region; other site 756272010201 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 756272010202 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 756272010203 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 756272010204 metal binding site 2 [ion binding]; metal-binding site 756272010205 putative DNA binding helix; other site 756272010206 metal binding site 1 [ion binding]; metal-binding site 756272010207 dimer interface [polypeptide binding]; other site 756272010208 structural Zn2+ binding site [ion binding]; other site 756272010209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272010210 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272010211 Walker A/P-loop; other site 756272010212 ATP binding site [chemical binding]; other site 756272010213 Q-loop/lid; other site 756272010214 ABC transporter signature motif; other site 756272010215 Walker B; other site 756272010216 D-loop; other site 756272010217 H-loop/switch region; other site 756272010218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272010219 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 756272010220 FtsX-like permease family; Region: FtsX; pfam02687 756272010221 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 756272010222 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 756272010223 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 756272010224 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 756272010225 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010226 Sulfatase; Region: Sulfatase; pfam00884 756272010227 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 756272010228 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010229 Sulfatase; Region: Sulfatase; pfam00884 756272010230 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272010231 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 756272010232 NAD binding site [chemical binding]; other site 756272010233 putative substrate binding site 2 [chemical binding]; other site 756272010234 putative substrate binding site 1 [chemical binding]; other site 756272010235 active site 756272010236 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 756272010237 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 756272010238 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 756272010239 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 756272010240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010241 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 756272010242 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 756272010243 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 756272010244 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 756272010245 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 756272010246 Walker A/P-loop; other site 756272010247 ATP binding site [chemical binding]; other site 756272010248 Q-loop/lid; other site 756272010249 ABC transporter signature motif; other site 756272010250 Walker B; other site 756272010251 D-loop; other site 756272010252 H-loop/switch region; other site 756272010253 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 756272010254 putative carbohydrate binding site [chemical binding]; other site 756272010255 Methyltransferase domain; Region: Methyltransf_24; pfam13578 756272010256 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272010257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010258 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 756272010259 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 756272010260 GDP-Fucose binding site [chemical binding]; other site 756272010261 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 756272010262 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: COG2074 756272010263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272010264 active site 756272010265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010266 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272010267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010268 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272010269 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 756272010270 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 756272010271 active site 756272010272 Methyltransferase domain; Region: Methyltransf_23; pfam13489 756272010273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272010274 S-adenosylmethionine binding site [chemical binding]; other site 756272010275 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272010276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 756272010277 active site 756272010278 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 756272010279 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272010280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 756272010281 active site 756272010282 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 756272010283 active site 756272010284 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 756272010285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 756272010286 active site 756272010287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010288 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272010289 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272010290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010291 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 756272010292 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 756272010294 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 756272010295 putative ADP-binding pocket [chemical binding]; other site 756272010296 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 756272010297 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 756272010298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272010299 TPR motif; other site 756272010300 binding surface 756272010301 putative acyl transferase; Provisional; Region: PRK10502 756272010302 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 756272010303 putative trimer interface [polypeptide binding]; other site 756272010304 putative active site [active] 756272010305 putative substrate binding site [chemical binding]; other site 756272010306 putative CoA binding site [chemical binding]; other site 756272010307 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 756272010308 putative active site [active] 756272010309 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 756272010310 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 756272010311 O-Antigen ligase; Region: Wzy_C; pfam04932 756272010312 Tetratricopeptide repeat; Region: TPR_16; pfam13432 756272010313 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 756272010314 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 756272010315 Mg++ binding site [ion binding]; other site 756272010316 putative catalytic motif [active] 756272010317 substrate binding site [chemical binding]; other site 756272010318 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 756272010319 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 756272010320 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 756272010321 NADP binding site [chemical binding]; other site 756272010322 active site 756272010323 putative substrate binding site [chemical binding]; other site 756272010324 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 756272010325 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 756272010326 NADP-binding site; other site 756272010327 homotetramer interface [polypeptide binding]; other site 756272010328 substrate binding site [chemical binding]; other site 756272010329 homodimer interface [polypeptide binding]; other site 756272010330 active site 756272010331 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 756272010332 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 756272010333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272010334 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 756272010335 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 756272010336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272010337 TPR motif; other site 756272010338 binding surface 756272010339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272010340 TPR motif; other site 756272010341 binding surface 756272010342 TPR repeat; Region: TPR_11; pfam13414 756272010343 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 756272010344 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010345 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 756272010346 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 756272010347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 756272010348 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 756272010349 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 756272010350 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 756272010351 intersubunit interface [polypeptide binding]; other site 756272010352 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010353 Right handed beta helix region; Region: Beta_helix; pfam13229 756272010354 Right handed beta helix region; Region: Beta_helix; pfam13229 756272010355 FecR protein; Region: FecR; pfam04773 756272010356 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272010357 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272010358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272010359 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010360 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010361 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010362 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010363 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272010364 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272010365 DNA interaction; other site 756272010366 Metal-binding active site; metal-binding site 756272010367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272010368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272010369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 756272010370 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272010371 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272010372 inhibitor site; inhibition site 756272010373 active site 756272010374 dimer interface [polypeptide binding]; other site 756272010375 catalytic residue [active] 756272010376 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 756272010377 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 756272010378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010380 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 756272010381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272010382 Walker A motif; other site 756272010383 ATP binding site [chemical binding]; other site 756272010384 Walker B motif; other site 756272010385 arginine finger; other site 756272010386 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 756272010387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 756272010388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 756272010389 DNA-binding site [nucleotide binding]; DNA binding site 756272010390 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 756272010391 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272010392 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272010393 inhibitor site; inhibition site 756272010394 active site 756272010395 dimer interface [polypeptide binding]; other site 756272010396 catalytic residue [active] 756272010397 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 756272010398 Na binding site [ion binding]; other site 756272010399 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010400 Sulfatase; Region: Sulfatase; pfam00884 756272010401 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010402 Sulfatase; Region: Sulfatase; pfam00884 756272010403 Family description; Region: VCBS; pfam13517 756272010404 FG-GAP repeat; Region: FG-GAP; pfam01839 756272010405 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 756272010406 BNR repeat-like domain; Region: BNR_2; pfam13088 756272010407 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010408 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272010409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272010410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272010411 DNA binding residues [nucleotide binding] 756272010412 FecR protein; Region: FecR; pfam04773 756272010413 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272010414 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010415 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010416 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010417 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010418 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 756272010419 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 756272010420 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 756272010421 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 756272010422 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 756272010423 DXD motif; other site 756272010424 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 756272010425 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 756272010426 SnoaL-like domain; Region: SnoaL_3; pfam13474 756272010427 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 756272010428 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272010429 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272010430 Walker A/P-loop; other site 756272010431 ATP binding site [chemical binding]; other site 756272010432 Q-loop/lid; other site 756272010433 ABC transporter signature motif; other site 756272010434 Walker B; other site 756272010435 D-loop; other site 756272010436 H-loop/switch region; other site 756272010437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272010438 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272010439 FtsX-like permease family; Region: FtsX; pfam02687 756272010440 FtsX-like permease family; Region: FtsX; pfam02687 756272010441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272010442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 756272010443 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 756272010444 Walker A/P-loop; other site 756272010445 ATP binding site [chemical binding]; other site 756272010446 Q-loop/lid; other site 756272010447 ABC transporter signature motif; other site 756272010448 Walker B; other site 756272010449 D-loop; other site 756272010450 H-loop/switch region; other site 756272010451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 756272010452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 756272010453 FtsX-like permease family; Region: FtsX; pfam02687 756272010454 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010455 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 756272010456 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010457 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010458 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010459 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010460 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 756272010462 DNA-binding site [nucleotide binding]; DNA binding site 756272010463 Transcriptional regulators [Transcription]; Region: GntR; COG1802 756272010464 FCD domain; Region: FCD; pfam07729 756272010465 galactonate dehydratase; Provisional; Region: PRK14017 756272010466 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 756272010467 metal binding site [ion binding]; metal-binding site 756272010468 substrate binding pocket [chemical binding]; other site 756272010469 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 756272010470 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272010471 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272010472 inhibitor site; inhibition site 756272010473 active site 756272010474 dimer interface [polypeptide binding]; other site 756272010475 catalytic residue [active] 756272010476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272010477 D-galactonate transporter; Region: 2A0114; TIGR00893 756272010478 putative substrate translocation pore; other site 756272010479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 756272010480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272010481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272010482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010483 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 756272010484 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 756272010485 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 756272010486 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 756272010487 active site 756272010488 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 756272010489 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 756272010490 catalytic triad [active] 756272010491 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 756272010492 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272010493 conserved cys residue [active] 756272010494 Beta-lactamase; Region: Beta-lactamase; pfam00144 756272010495 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 756272010496 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 756272010497 Sulfatase; Region: Sulfatase; pfam00884 756272010498 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010499 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272010500 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010501 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 756272010502 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 756272010503 conserved cys residue [active] 756272010504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010506 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 756272010507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 756272010508 dimer interface [polypeptide binding]; other site 756272010509 conserved gate region; other site 756272010510 putative PBP binding loops; other site 756272010511 ABC-ATPase subunit interface; other site 756272010512 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 756272010513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 756272010514 substrate binding pocket [chemical binding]; other site 756272010515 membrane-bound complex binding site; other site 756272010516 hinge residues; other site 756272010517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 756272010518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 756272010519 Walker A/P-loop; other site 756272010520 ATP binding site [chemical binding]; other site 756272010521 Q-loop/lid; other site 756272010522 ABC transporter signature motif; other site 756272010523 Walker B; other site 756272010524 D-loop; other site 756272010525 H-loop/switch region; other site 756272010526 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 756272010527 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 756272010528 inhibitor-cofactor binding pocket; inhibition site 756272010529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272010530 catalytic residue [active] 756272010531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 756272010532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 756272010533 active site 756272010534 catalytic tetrad [active] 756272010535 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 756272010536 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 756272010537 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 756272010538 conserved cys residue [active] 756272010539 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 756272010540 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272010541 conserved cys residue [active] 756272010542 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 756272010543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272010544 putative metal binding site [ion binding]; other site 756272010545 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 756272010546 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 756272010547 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010548 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010549 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 756272010550 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010551 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010552 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010553 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010554 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010555 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 756272010556 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010557 Prostaglandin dehydrogenases; Region: PGDH; cd05288 756272010558 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 756272010559 NAD(P) binding site [chemical binding]; other site 756272010560 substrate binding site [chemical binding]; other site 756272010561 dimer interface [polypeptide binding]; other site 756272010562 Trehalose utilisation; Region: ThuA; pfam06283 756272010563 conserved cys residue [active] 756272010564 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272010565 HEAT repeats; Region: HEAT_2; pfam13646 756272010566 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 756272010567 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272010568 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 756272010569 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 756272010570 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272010572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272010573 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 756272010575 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 756272010576 putative dimerization interface [polypeptide binding]; other site 756272010577 putative ligand binding site [chemical binding]; other site 756272010578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 756272010580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 756272010581 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272010582 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 756272010583 DNA interaction; other site 756272010584 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272010585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272010586 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 756272010587 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 756272010588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 756272010589 Predicted permease; Region: DUF318; cl17795 756272010590 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 756272010591 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272010592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272010593 Walker B motif; other site 756272010594 arginine finger; other site 756272010595 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 756272010596 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 756272010597 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 756272010598 Protein of unknown function DUF58; Region: DUF58; pfam01882 756272010599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272010600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 756272010601 active site 756272010602 ATP binding site [chemical binding]; other site 756272010603 substrate binding site [chemical binding]; other site 756272010604 activation loop (A-loop); other site 756272010605 PAS domain S-box; Region: sensory_box; TIGR00229 756272010606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272010607 putative active site [active] 756272010608 heme pocket [chemical binding]; other site 756272010609 PAS domain S-box; Region: sensory_box; TIGR00229 756272010610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 756272010611 putative active site [active] 756272010612 heme pocket [chemical binding]; other site 756272010613 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 756272010614 putative active site [active] 756272010615 putative metal binding site [ion binding]; other site 756272010616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 756272010617 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010618 Sulfatase; Region: Sulfatase; pfam00884 756272010619 Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198 756272010620 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 756272010621 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 756272010622 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 756272010623 Cytochrome c552; Region: Cytochrom_C552; pfam02335 756272010624 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010625 Sulfatase; Region: Sulfatase; pfam00884 756272010626 BNR repeat-like domain; Region: BNR_2; pfam13088 756272010627 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272010628 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272010629 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272010630 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272010631 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 756272010632 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 756272010633 DNA binding residues [nucleotide binding] 756272010634 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 756272010635 dimer interface [polypeptide binding]; other site 756272010636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272010637 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 756272010638 SnoaL-like domain; Region: SnoaL_3; pfam13474 756272010639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 756272010640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 756272010641 YCII-related domain; Region: YCII; cl00999 756272010642 DoxX-like family; Region: DoxX_2; pfam13564 756272010643 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 756272010644 putative dimer interface [polypeptide binding]; other site 756272010645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 756272010646 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 756272010647 succinylarginine dihydrolase; Provisional; Region: PRK13281 756272010648 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 756272010649 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 756272010650 NAD(P) binding site [chemical binding]; other site 756272010651 catalytic residues [active] 756272010652 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 756272010653 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 756272010654 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 756272010655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 756272010656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272010657 catalytic residue [active] 756272010658 hypothetical protein; Provisional; Region: PRK07338 756272010659 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 756272010660 metal binding site [ion binding]; metal-binding site 756272010661 dimer interface [polypeptide binding]; other site 756272010662 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272010663 Sulfatase; Region: Sulfatase; cl17466 756272010664 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 756272010665 B12 binding site [chemical binding]; other site 756272010666 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 756272010667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272010668 FeS/SAM binding site; other site 756272010669 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 756272010670 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 756272010671 Asp-box motif; other site 756272010672 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 756272010673 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 756272010674 motif 1; other site 756272010675 dimer interface [polypeptide binding]; other site 756272010676 active site 756272010677 motif 2; other site 756272010678 motif 3; other site 756272010679 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 756272010680 ATP cone domain; Region: ATP-cone; pfam03477 756272010681 ATP cone domain; Region: ATP-cone; pfam03477 756272010682 Class I ribonucleotide reductase; Region: RNR_I; cd01679 756272010683 active site 756272010684 dimer interface [polypeptide binding]; other site 756272010685 catalytic residues [active] 756272010686 effector binding site; other site 756272010687 R2 peptide binding site; other site 756272010688 GxxExxY protein; Region: GxxExxY; TIGR04256 756272010689 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 756272010690 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 756272010691 dimer interface [polypeptide binding]; other site 756272010692 putative radical transfer pathway; other site 756272010693 diiron center [ion binding]; other site 756272010694 tyrosyl radical; other site 756272010695 ribonuclease PH; Reviewed; Region: rph; PRK00173 756272010696 Ribonuclease PH; Region: RNase_PH_bact; cd11362 756272010697 hexamer interface [polypeptide binding]; other site 756272010698 active site 756272010699 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 756272010700 rRNA interaction site [nucleotide binding]; other site 756272010701 S8 interaction site; other site 756272010702 putative laminin-1 binding site; other site 756272010703 elongation factor Ts; Provisional; Region: tsf; PRK09377 756272010704 UBA/TS-N domain; Region: UBA; pfam00627 756272010705 Elongation factor TS; Region: EF_TS; pfam00889 756272010706 Elongation factor TS; Region: EF_TS; pfam00889 756272010707 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 756272010708 putative nucleotide binding site [chemical binding]; other site 756272010709 uridine monophosphate binding site [chemical binding]; other site 756272010710 homohexameric interface [polypeptide binding]; other site 756272010711 ribosome recycling factor; Reviewed; Region: frr; PRK00083 756272010712 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 756272010713 hinge region; other site 756272010714 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 756272010715 HDOD domain; Region: HDOD; pfam08668 756272010716 HDOD domain; Region: HDOD; pfam08668 756272010717 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 756272010718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272010719 S-adenosylmethionine binding site [chemical binding]; other site 756272010720 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 756272010721 DHH family; Region: DHH; pfam01368 756272010722 DHHA1 domain; Region: DHHA1; pfam02272 756272010723 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 756272010724 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272010725 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272010726 Cytochrome c; Region: Cytochrom_C; pfam00034 756272010727 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 756272010728 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 756272010729 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 756272010730 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 756272010731 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 756272010732 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 756272010733 inhibitor site; inhibition site 756272010734 active site 756272010735 dimer interface [polypeptide binding]; other site 756272010736 catalytic residue [active] 756272010737 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 756272010738 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 756272010739 triosephosphate isomerase; Provisional; Region: PRK14567 756272010740 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 756272010741 substrate binding site [chemical binding]; other site 756272010742 dimer interface [polypeptide binding]; other site 756272010743 catalytic triad [active] 756272010744 hypothetical protein; Provisional; Region: PRK11820 756272010745 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 756272010746 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 756272010747 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 756272010748 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 756272010749 catalytic site [active] 756272010750 G-X2-G-X-G-K; other site 756272010751 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 756272010752 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 756272010753 Flavoprotein; Region: Flavoprotein; pfam02441 756272010754 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 756272010755 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 756272010756 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 756272010757 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 756272010758 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 756272010759 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 756272010760 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272010761 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 756272010762 phosphopeptide binding site; other site 756272010763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 756272010764 FAD binding domain; Region: FAD_binding_4; pfam01565 756272010765 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 756272010766 Uncharacterized conserved protein [Function unknown]; Region: COG1359 756272010767 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 756272010768 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 756272010769 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 756272010770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 756272010771 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272010772 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272010773 active site 756272010774 ATP binding site [chemical binding]; other site 756272010775 substrate binding site [chemical binding]; other site 756272010776 activation loop (A-loop); other site 756272010777 Right handed beta helix region; Region: Beta_helix; pfam13229 756272010778 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 756272010779 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 756272010780 homodimer interface [polypeptide binding]; other site 756272010781 substrate-cofactor binding pocket; other site 756272010782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272010783 catalytic residue [active] 756272010784 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 756272010785 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 756272010786 Cu(I) binding site [ion binding]; other site 756272010787 Protein of unknown function (DUF420); Region: DUF420; pfam04238 756272010788 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 756272010789 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 756272010790 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 756272010791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272010792 active site 756272010793 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 756272010794 gamma-glutamyl kinase; Provisional; Region: PRK05429 756272010795 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 756272010796 nucleotide binding site [chemical binding]; other site 756272010797 homotetrameric interface [polypeptide binding]; other site 756272010798 putative phosphate binding site [ion binding]; other site 756272010799 putative allosteric binding site; other site 756272010800 PUA domain; Region: PUA; pfam01472 756272010801 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 756272010802 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 756272010803 dimer interface [polypeptide binding]; other site 756272010804 NADP binding site [chemical binding]; other site 756272010805 catalytic residues [active] 756272010806 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272010807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272010808 active site 756272010809 ATP binding site [chemical binding]; other site 756272010810 substrate binding site [chemical binding]; other site 756272010811 activation loop (A-loop); other site 756272010812 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272010813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272010814 Walker A motif; other site 756272010815 ATP binding site [chemical binding]; other site 756272010816 Walker B motif; other site 756272010817 RNA dependent RNA polymerase; Region: RdRP_2; pfam00978 756272010818 arginine finger; other site 756272010819 Outer membrane efflux protein; Region: OEP; pfam02321 756272010820 Outer membrane efflux protein; Region: OEP; pfam02321 756272010821 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 756272010822 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272010823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 756272010824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272010825 Walker A/P-loop; other site 756272010826 ATP binding site [chemical binding]; other site 756272010827 Q-loop/lid; other site 756272010828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272010829 Walker B; other site 756272010830 D-loop; other site 756272010831 H-loop/switch region; other site 756272010832 Rhomboid family; Region: Rhomboid; pfam01694 756272010833 TPR repeat; Region: TPR_11; pfam13414 756272010834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 756272010835 binding surface 756272010836 TPR motif; other site 756272010837 Predicted membrane protein [Function unknown]; Region: COG2323 756272010838 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 756272010839 MgtC family; Region: MgtC; pfam02308 756272010840 Protein of unknown function (DUF805); Region: DUF805; pfam05656 756272010841 Protein of unknown function (DUF805); Region: DUF805; pfam05656 756272010842 Protein of unknown function (DUF805); Region: DUF805; pfam05656 756272010843 Protein of unknown function (DUF805); Region: DUF805; pfam05656 756272010844 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 756272010845 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 756272010846 nucleotide binding pocket [chemical binding]; other site 756272010847 K-X-D-G motif; other site 756272010848 catalytic site [active] 756272010849 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 756272010850 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 756272010851 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 756272010852 Dimer interface [polypeptide binding]; other site 756272010853 BRCT sequence motif; other site 756272010854 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 756272010855 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 756272010856 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 756272010857 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 756272010858 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 756272010859 active site 756272010860 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 756272010861 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 756272010862 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272010863 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 756272010864 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 756272010865 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272010866 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 756272010867 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 756272010868 active site 756272010869 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 756272010870 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 756272010871 Zn2+ binding site [ion binding]; other site 756272010872 Mg2+ binding site [ion binding]; other site 756272010873 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 756272010874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272010875 ATP binding site [chemical binding]; other site 756272010876 putative Mg++ binding site [ion binding]; other site 756272010877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272010878 nucleotide binding region [chemical binding]; other site 756272010879 ATP-binding site [chemical binding]; other site 756272010880 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 756272010881 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 756272010882 MraZ protein; Region: MraZ; pfam02381 756272010883 cell division protein MraZ; Reviewed; Region: PRK00326 756272010884 MraZ protein; Region: MraZ; pfam02381 756272010885 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272010886 active site 756272010887 catalytic triad [active] 756272010888 oxyanion hole [active] 756272010889 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272010890 HEAT repeats; Region: HEAT_2; pfam13646 756272010891 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272010892 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272010893 HsdM N-terminal domain; Region: HsdM_N; pfam12161 756272010894 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 756272010895 Methyltransferase domain; Region: Methyltransf_26; pfam13659 756272010896 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 756272010897 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 756272010898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 756272010899 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 756272010900 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 756272010901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272010902 ATP binding site [chemical binding]; other site 756272010903 putative Mg++ binding site [ion binding]; other site 756272010904 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 756272010905 NPCBM/NEW2 domain; Region: NPCBM; cl07060 756272010906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272010907 Response regulator receiver domain; Region: Response_reg; pfam00072 756272010908 active site 756272010909 phosphorylation site [posttranslational modification] 756272010910 intermolecular recognition site; other site 756272010911 dimerization interface [polypeptide binding]; other site 756272010912 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272010913 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272010914 Trp docking motif [polypeptide binding]; other site 756272010915 PQQ-like domain; Region: PQQ_2; pfam13360 756272010916 active site 756272010917 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 756272010918 S17 interaction site [polypeptide binding]; other site 756272010919 S8 interaction site; other site 756272010920 16S rRNA interaction site [nucleotide binding]; other site 756272010921 streptomycin interaction site [chemical binding]; other site 756272010922 23S rRNA interaction site [nucleotide binding]; other site 756272010923 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 756272010924 30S ribosomal protein S7; Validated; Region: PRK05302 756272010925 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 756272010926 putative active site [active] 756272010927 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 756272010928 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 756272010929 active site 756272010930 ATP binding site [chemical binding]; other site 756272010931 substrate binding site [chemical binding]; other site 756272010932 activation loop (A-loop); other site 756272010933 phosphodiesterase; Provisional; Region: PRK12704 756272010934 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 756272010935 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 756272010936 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 756272010937 ADP-glucose phosphorylase; Region: PLN02643 756272010938 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 756272010939 nucleotide binding site/active site [active] 756272010940 HIT family signature motif; other site 756272010941 catalytic residue [active] 756272010942 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 756272010943 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 756272010944 active site 756272010945 catalytic site [active] 756272010946 homodimer interface [polypeptide binding]; other site 756272010947 Lid 1; other site 756272010948 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 756272010949 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 756272010950 Chain length determinant protein; Region: Wzz; cl15801 756272010951 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 756272010952 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 756272010953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272010954 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 756272010955 NAD binding site [chemical binding]; other site 756272010956 substrate binding site [chemical binding]; other site 756272010957 homodimer interface [polypeptide binding]; other site 756272010958 active site 756272010959 Domain of unknown function (DUF303); Region: DUF303; pfam03629 756272010960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 756272010961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 756272010962 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 756272010963 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 756272010964 dimerization interface [polypeptide binding]; other site 756272010965 metal binding site [ion binding]; metal-binding site 756272010966 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 756272010967 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 756272010968 NAD(P) binding site [chemical binding]; other site 756272010969 catalytic residues [active] 756272010970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272010971 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 756272010972 NAD(P) binding site [chemical binding]; other site 756272010973 active site 756272010974 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 756272010975 putative active site [active] 756272010976 redox center [active] 756272010977 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 756272010978 RNA pol II promoter Fmp27 protein domain; Region: Fmp27_WPPW; pfam10359 756272010979 Dodecin; Region: Dodecin; pfam07311 756272010980 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 756272010981 active site residue [active] 756272010982 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 756272010983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272010984 active site 756272010985 phosphorylation site [posttranslational modification] 756272010986 intermolecular recognition site; other site 756272010987 dimerization interface [polypeptide binding]; other site 756272010988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 756272010989 DNA binding residues [nucleotide binding] 756272010990 dimerization interface [polypeptide binding]; other site 756272010991 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 756272010992 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 756272010993 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 756272010994 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 756272010995 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 756272010996 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 756272010997 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 756272010998 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 756272010999 active site 756272011000 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 756272011001 protein binding site [polypeptide binding]; other site 756272011002 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 756272011003 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 756272011004 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 756272011005 putative substrate binding region [chemical binding]; other site 756272011006 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 756272011007 anti sigma factor interaction site; other site 756272011008 regulatory phosphorylation site [posttranslational modification]; other site 756272011009 glycogen branching enzyme; Provisional; Region: PRK12313 756272011010 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 756272011011 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 756272011012 active site 756272011013 catalytic site [active] 756272011014 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 756272011015 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 756272011016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 756272011017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272011018 homodimer interface [polypeptide binding]; other site 756272011019 catalytic residue [active] 756272011020 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 756272011021 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 756272011022 Domain of unknown function DUF11; Region: DUF11; pfam01345 756272011023 Domain of unknown function DUF11; Region: DUF11; cl17728 756272011024 Helix-turn-helix domain; Region: HTH_17; pfam12728 756272011025 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 756272011026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272011027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 756272011028 DNA binding residues [nucleotide binding] 756272011029 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 756272011030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272011031 Response regulator receiver domain; Region: Response_reg; pfam00072 756272011032 active site 756272011033 phosphorylation site [posttranslational modification] 756272011034 intermolecular recognition site; other site 756272011035 dimerization interface [polypeptide binding]; other site 756272011036 HDOD domain; Region: HDOD; pfam08668 756272011037 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 756272011038 ATP cone domain; Region: ATP-cone; pfam03477 756272011039 GMP synthase; Reviewed; Region: guaA; PRK00074 756272011040 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 756272011041 AMP/PPi binding site [chemical binding]; other site 756272011042 candidate oxyanion hole; other site 756272011043 catalytic triad [active] 756272011044 potential glutamine specificity residues [chemical binding]; other site 756272011045 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 756272011046 ATP Binding subdomain [chemical binding]; other site 756272011047 Ligand Binding sites [chemical binding]; other site 756272011048 Dimerization subdomain; other site 756272011049 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 756272011050 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 756272011051 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 756272011052 argininosuccinate synthase; Provisional; Region: PRK13820 756272011053 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 756272011054 ANP binding site [chemical binding]; other site 756272011055 Substrate Binding Site II [chemical binding]; other site 756272011056 Substrate Binding Site I [chemical binding]; other site 756272011057 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 756272011058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 756272011059 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272011060 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 756272011061 Metal-binding active site; metal-binding site 756272011062 HTH domain; Region: HTH_11; cl17392 756272011063 Predicted transcriptional regulator [Transcription]; Region: COG2378 756272011064 WYL domain; Region: WYL; pfam13280 756272011065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272011066 dimer interface [polypeptide binding]; other site 756272011067 phosphorylation site [posttranslational modification] 756272011068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272011069 ATP binding site [chemical binding]; other site 756272011070 Mg2+ binding site [ion binding]; other site 756272011071 G-X-G motif; other site 756272011072 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 756272011073 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 756272011074 RNase E interface [polypeptide binding]; other site 756272011075 trimer interface [polypeptide binding]; other site 756272011076 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 756272011077 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 756272011078 RNase E interface [polypeptide binding]; other site 756272011079 trimer interface [polypeptide binding]; other site 756272011080 active site 756272011081 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 756272011082 putative nucleic acid binding region [nucleotide binding]; other site 756272011083 G-X-X-G motif; other site 756272011084 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 756272011085 RNA binding site [nucleotide binding]; other site 756272011086 domain interface; other site 756272011087 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 756272011088 16S/18S rRNA binding site [nucleotide binding]; other site 756272011089 S13e-L30e interaction site [polypeptide binding]; other site 756272011090 25S rRNA binding site [nucleotide binding]; other site 756272011091 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011092 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272011093 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272011094 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272011095 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 756272011096 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 756272011097 active site 756272011098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272011099 active site 756272011100 Cation efflux family; Region: Cation_efflux; pfam01545 756272011101 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 756272011102 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 756272011103 PQQ-like domain; Region: PQQ_2; pfam13360 756272011104 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 756272011105 Trp docking motif [polypeptide binding]; other site 756272011106 active site 756272011107 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 756272011108 HEAT repeats; Region: HEAT_2; pfam13646 756272011109 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 756272011110 active site 756272011111 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 756272011112 metal ion-dependent adhesion site (MIDAS); other site 756272011113 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 756272011114 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 756272011115 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 756272011116 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 756272011117 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 756272011118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272011119 active site 756272011120 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 756272011121 Leucine rich repeat; Region: LRR_8; pfam13855 756272011122 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 756272011123 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 756272011124 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 756272011125 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 756272011126 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 756272011127 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 756272011128 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 756272011129 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 756272011130 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272011131 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 756272011132 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 756272011133 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 756272011134 PQQ-like domain; Region: PQQ_2; pfam13360 756272011135 DinB superfamily; Region: DinB_2; pfam12867 756272011136 DinB family; Region: DinB; cl17821 756272011137 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 756272011138 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 756272011140 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011141 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272011142 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 756272011143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272011144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272011145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272011146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272011147 putative substrate translocation pore; other site 756272011148 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 756272011149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 756272011150 RNA binding surface [nucleotide binding]; other site 756272011151 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 756272011152 active site 756272011153 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 756272011154 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 756272011155 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 756272011156 dimer interface [polypeptide binding]; other site 756272011157 TPP-binding site [chemical binding]; other site 756272011158 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 756272011159 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 756272011160 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 756272011161 E3 interaction surface; other site 756272011162 lipoyl attachment site [posttranslational modification]; other site 756272011163 e3 binding domain; Region: E3_binding; pfam02817 756272011164 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 756272011165 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 756272011166 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 756272011167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 756272011168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 756272011169 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 756272011170 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 756272011171 FAD binding pocket [chemical binding]; other site 756272011172 FAD binding motif [chemical binding]; other site 756272011173 phosphate binding motif [ion binding]; other site 756272011174 beta-alpha-beta structure motif; other site 756272011175 NAD binding pocket [chemical binding]; other site 756272011176 Iron coordination center [ion binding]; other site 756272011177 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 756272011178 IHF dimer interface [polypeptide binding]; other site 756272011179 IHF - DNA interface [nucleotide binding]; other site 756272011180 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 756272011181 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 756272011182 heterodimer interface [polypeptide binding]; other site 756272011183 active site 756272011184 FMN binding site [chemical binding]; other site 756272011185 homodimer interface [polypeptide binding]; other site 756272011186 substrate binding site [chemical binding]; other site 756272011187 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 756272011188 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 756272011189 active site 756272011190 HIGH motif; other site 756272011191 dimer interface [polypeptide binding]; other site 756272011192 KMSKS motif; other site 756272011193 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 756272011194 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272011195 hypothetical protein; Provisional; Region: PRK08609 756272011196 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 756272011197 active site 756272011198 primer binding site [nucleotide binding]; other site 756272011199 NTP binding site [chemical binding]; other site 756272011200 metal binding triad [ion binding]; metal-binding site 756272011201 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 756272011202 active site 756272011203 BON domain; Region: BON; pfam04972 756272011204 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011205 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 756272011206 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 756272011207 Ligand Binding Site [chemical binding]; other site 756272011208 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 756272011209 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 756272011210 ADP binding site [chemical binding]; other site 756272011211 phosphagen binding site; other site 756272011212 substrate specificity loop; other site 756272011213 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 756272011214 active site 756272011215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 756272011216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 756272011217 Coenzyme A binding pocket [chemical binding]; other site 756272011218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 756272011219 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 756272011220 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 756272011221 active site 756272011222 Zn binding site [ion binding]; other site 756272011223 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272011224 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 756272011225 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272011226 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 756272011227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 756272011228 FeS/SAM binding site; other site 756272011229 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 756272011230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272011231 putative substrate translocation pore; other site 756272011232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272011233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272011234 putative substrate translocation pore; other site 756272011235 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 756272011236 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 756272011237 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 756272011238 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 756272011239 active site 756272011240 catalytic triad [active] 756272011241 oxyanion hole [active] 756272011242 rod shape-determining protein MreB; Provisional; Region: PRK13930 756272011243 MreB and similar proteins; Region: MreB_like; cd10225 756272011244 nucleotide binding site [chemical binding]; other site 756272011245 Mg binding site [ion binding]; other site 756272011246 putative protofilament interaction site [polypeptide binding]; other site 756272011247 RodZ interaction site [polypeptide binding]; other site 756272011248 rod shape-determining protein MreC; Provisional; Region: PRK13922 756272011249 rod shape-determining protein MreC; Region: MreC; pfam04085 756272011250 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 756272011251 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 756272011252 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011253 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 756272011254 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 756272011255 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 756272011256 trimer interface [polypeptide binding]; other site 756272011257 active site 756272011258 UDP-GlcNAc binding site [chemical binding]; other site 756272011259 lipid binding site [chemical binding]; lipid-binding site 756272011260 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 756272011261 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 756272011262 phosphopeptide binding site; other site 756272011263 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 756272011264 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 756272011265 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 756272011266 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 756272011267 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 756272011268 homotrimer interaction site [polypeptide binding]; other site 756272011269 zinc binding site [ion binding]; other site 756272011270 CDP-binding sites; other site 756272011271 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 756272011272 active site 756272011273 putative DNA-binding cleft [nucleotide binding]; other site 756272011274 dimer interface [polypeptide binding]; other site 756272011275 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 756272011276 Methane oxygenase PmoA; Region: PmoA; pfam14100 756272011277 CoA binding domain; Region: CoA_binding_2; pfam13380 756272011278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 756272011279 FIST N domain; Region: FIST; pfam08495 756272011280 FIST C domain; Region: FIST_C; pfam10442 756272011281 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 756272011282 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 756272011283 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 756272011284 Rod binding protein; Region: Rod-binding; pfam10135 756272011285 Flagellar P-ring protein; Region: FlgI; pfam02119 756272011286 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 756272011287 Flagellar L-ring protein; Region: FlgH; cl17277 756272011288 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 756272011289 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 756272011290 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 756272011291 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 756272011292 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 756272011293 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 756272011294 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 756272011295 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 756272011296 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 756272011297 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011298 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 756272011299 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011300 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 756272011301 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011302 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011303 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011304 CHAT domain; Region: CHAT; cl17868 756272011305 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 756272011306 active site 756272011307 catalytic triad [active] 756272011308 oxyanion hole [active] 756272011309 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 756272011310 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 756272011311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 756272011312 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 756272011313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 756272011314 S-adenosylmethionine binding site [chemical binding]; other site 756272011315 conserved repeat domain; Region: B_ant_repeat; TIGR01451 756272011316 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 756272011317 ligand-binding site [chemical binding]; other site 756272011318 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 756272011319 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 756272011320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 756272011321 catalytic residue [active] 756272011322 Fatty acid desaturase; Region: FA_desaturase; pfam00487 756272011323 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 756272011324 Di-iron ligands [ion binding]; other site 756272011325 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 756272011326 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 756272011327 active site 756272011328 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272011329 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272011330 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 756272011331 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272011332 rhodanese superfamily protein; Provisional; Region: PRK05320 756272011333 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 756272011334 active site residue [active] 756272011335 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 756272011336 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 756272011337 active site 756272011338 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 756272011339 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 756272011340 inhibitor-cofactor binding pocket; inhibition site 756272011341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272011342 catalytic residue [active] 756272011343 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 756272011344 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 756272011345 Ligand binding site; other site 756272011346 Putative Catalytic site; other site 756272011347 DXD motif; other site 756272011348 Transcriptional regulators [Transcription]; Region: FadR; COG2186 756272011349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 756272011350 DNA-binding site [nucleotide binding]; DNA binding site 756272011351 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 756272011352 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 756272011353 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272011354 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272011355 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272011356 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272011357 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 756272011358 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 756272011359 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 756272011360 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 756272011361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272011362 active site 756272011363 phosphorylation site [posttranslational modification] 756272011364 intermolecular recognition site; other site 756272011365 dimerization interface [polypeptide binding]; other site 756272011366 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 756272011367 Protein of unknown function DUF116; Region: DUF116; pfam01976 756272011368 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 756272011369 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 756272011370 substrate binding pocket [chemical binding]; other site 756272011371 chain length determination region; other site 756272011372 substrate-Mg2+ binding site; other site 756272011373 catalytic residues [active] 756272011374 aspartate-rich region 1; other site 756272011375 active site lid residues [active] 756272011376 aspartate-rich region 2; other site 756272011377 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 756272011378 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 756272011379 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 756272011380 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 756272011381 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 756272011382 Mechanosensitive ion channel; Region: MS_channel; pfam00924 756272011383 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 756272011384 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 756272011385 Mg++ binding site [ion binding]; other site 756272011386 putative catalytic motif [active] 756272011387 putative substrate binding site [chemical binding]; other site 756272011388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 756272011389 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 756272011390 domain_subunit interface; other site 756272011391 peptide synthase; Provisional; Region: PRK09274 756272011392 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 756272011393 acyl-activating enzyme (AAE) consensus motif; other site 756272011394 putative AMP binding site [chemical binding]; other site 756272011395 putative active site [active] 756272011396 putative CoA binding site [chemical binding]; other site 756272011397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 756272011398 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 756272011399 NAD(P) binding site [chemical binding]; other site 756272011400 active site 756272011401 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272011402 Sulfatase; Region: Sulfatase; pfam00884 756272011403 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 756272011404 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 756272011405 putative ligand binding site [chemical binding]; other site 756272011406 putative NAD binding site [chemical binding]; other site 756272011407 catalytic site [active] 756272011408 signal recognition particle protein; Provisional; Region: PRK10867 756272011409 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 756272011410 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 756272011411 P loop; other site 756272011412 GTP binding site [chemical binding]; other site 756272011413 Signal peptide binding domain; Region: SRP_SPB; pfam02978 756272011414 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 756272011415 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 756272011416 tetramer interface [polypeptide binding]; other site 756272011417 active site 756272011418 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 756272011419 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011420 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011421 protein binding site [polypeptide binding]; other site 756272011422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011423 TPR motif; other site 756272011424 TPR repeat; Region: TPR_11; pfam13414 756272011425 binding surface 756272011426 TPR repeat; Region: TPR_11; pfam13414 756272011427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011428 binding surface 756272011429 TPR motif; other site 756272011430 TPR repeat; Region: TPR_11; pfam13414 756272011431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011432 binding surface 756272011433 TPR motif; other site 756272011434 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 756272011435 TPP-binding site [chemical binding]; other site 756272011436 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 756272011437 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 756272011438 PYR/PP interface [polypeptide binding]; other site 756272011439 dimer interface [polypeptide binding]; other site 756272011440 TPP binding site [chemical binding]; other site 756272011441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 756272011442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 756272011443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 756272011444 Walker A/P-loop; other site 756272011445 ATP binding site [chemical binding]; other site 756272011446 Q-loop/lid; other site 756272011447 ABC transporter signature motif; other site 756272011448 Walker B; other site 756272011449 D-loop; other site 756272011450 H-loop/switch region; other site 756272011451 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 756272011452 classical (c) SDRs; Region: SDR_c; cd05233 756272011453 NAD(P) binding site [chemical binding]; other site 756272011454 active site 756272011455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272011456 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 756272011457 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 756272011458 heme-binding residues [chemical binding]; other site 756272011459 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 756272011460 molybdopterin cofactor binding site; other site 756272011461 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 756272011462 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 756272011463 4Fe-4S binding domain; Region: Fer4; cl02805 756272011464 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 756272011465 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 756272011466 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 756272011467 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 756272011468 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 756272011469 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 756272011470 Cu(I) binding site [ion binding]; other site 756272011471 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 756272011472 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 756272011473 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 756272011474 Cytochrome c; Region: Cytochrom_C; cl11414 756272011475 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 756272011476 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 756272011477 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 756272011478 Subunit I/III interface [polypeptide binding]; other site 756272011479 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 756272011480 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 756272011481 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 756272011482 Subunit I/III interface [polypeptide binding]; other site 756272011483 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 756272011484 Asp-box motif; other site 756272011485 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 756272011486 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272011487 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011488 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 756272011489 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011490 protein binding site [polypeptide binding]; other site 756272011491 Bacitracin resistance protein BacA; Region: BacA; pfam02673 756272011492 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 756272011493 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 756272011494 active site 756272011495 dimerization interface [polypeptide binding]; other site 756272011496 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 756272011497 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 756272011498 dimerization interface [polypeptide binding]; other site 756272011499 ligand binding site [chemical binding]; other site 756272011500 NADP binding site [chemical binding]; other site 756272011501 catalytic site [active] 756272011502 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 756272011503 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 756272011504 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 756272011505 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 756272011506 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 756272011507 ATP binding site [chemical binding]; other site 756272011508 Walker A motif; other site 756272011509 hexamer interface [polypeptide binding]; other site 756272011510 Walker B motif; other site 756272011511 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 756272011512 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272011513 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 756272011514 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 756272011515 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 756272011516 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 756272011517 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 756272011518 dimerization interface [polypeptide binding]; other site 756272011519 active site 756272011520 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 756272011521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272011522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 756272011523 excinuclease ABC subunit B; Provisional; Region: PRK05298 756272011524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 756272011525 ATP binding site [chemical binding]; other site 756272011526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 756272011527 nucleotide binding region [chemical binding]; other site 756272011528 ATP-binding site [chemical binding]; other site 756272011529 Ultra-violet resistance protein B; Region: UvrB; pfam12344 756272011530 UvrB/uvrC motif; Region: UVR; pfam02151 756272011531 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 756272011532 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011533 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011534 protein binding site [polypeptide binding]; other site 756272011535 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011536 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011537 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 756272011538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 756272011539 metal ion-dependent adhesion site (MIDAS); other site 756272011540 MG2 domain; Region: A2M_N; pfam01835 756272011541 Aerotolerance regulator N-terminal; Region: BatA; cl06567 756272011542 CARDB; Region: CARDB; pfam07705 756272011543 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272011544 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 756272011545 Protein of unknown function DUF58; Region: DUF58; pfam01882 756272011546 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 756272011547 metal ion-dependent adhesion site (MIDAS); other site 756272011548 MoxR-like ATPases [General function prediction only]; Region: COG0714 756272011549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272011550 Walker A motif; other site 756272011551 ATP binding site [chemical binding]; other site 756272011552 Walker B motif; other site 756272011553 arginine finger; other site 756272011554 Protein of unknown function, DUF480; Region: DUF480; cl01209 756272011555 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 756272011556 30S subunit binding site; other site 756272011557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 756272011558 active site 756272011559 phosphorylation site [posttranslational modification] 756272011560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 756272011561 dimerization domain swap beta strand [polypeptide binding]; other site 756272011562 regulatory protein interface [polypeptide binding]; other site 756272011563 active site 756272011564 regulatory phosphorylation site [posttranslational modification]; other site 756272011565 Predicted membrane protein [Function unknown]; Region: COG4270 756272011566 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 756272011567 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 756272011568 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 756272011569 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 756272011570 recombination protein RecR; Reviewed; Region: recR; PRK00076 756272011571 RecR protein; Region: RecR; pfam02132 756272011572 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 756272011573 putative active site [active] 756272011574 putative metal-binding site [ion binding]; other site 756272011575 tetramer interface [polypeptide binding]; other site 756272011576 hypothetical protein; Validated; Region: PRK00153 756272011577 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 756272011578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272011579 Walker A motif; other site 756272011580 ATP binding site [chemical binding]; other site 756272011581 Walker B motif; other site 756272011582 arginine finger; other site 756272011583 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 756272011584 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 756272011585 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 756272011586 active site 756272011587 Domain of unknown function (DUF309); Region: DUF309; pfam03745 756272011588 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272011589 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272011590 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272011591 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 756272011592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 756272011593 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 756272011594 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272011595 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272011596 diaminopimelate decarboxylase; Region: lysA; TIGR01048 756272011597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 756272011598 active site 756272011599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 756272011600 substrate binding site [chemical binding]; other site 756272011601 catalytic residues [active] 756272011602 dimer interface [polypeptide binding]; other site 756272011603 NIPSNAP; Region: NIPSNAP; pfam07978 756272011604 NIPSNAP; Region: NIPSNAP; pfam07978 756272011605 Transport protein; Region: actII; TIGR00833 756272011606 Transport protein; Region: actII; TIGR00833 756272011607 Quinolinate synthetase A protein; Region: NadA; pfam02445 756272011608 Resolvase, N terminal domain; Region: Resolvase; smart00857 756272011609 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 756272011610 catalytic residues [active] 756272011611 Recombinase; Region: Recombinase; pfam07508 756272011612 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 756272011613 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272011614 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 756272011615 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 756272011616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 756272011617 nucleotide binding region [chemical binding]; other site 756272011618 ATP-binding site [chemical binding]; other site 756272011619 GAF domain; Region: GAF_3; pfam13492 756272011620 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 756272011621 Peptidase family M50; Region: Peptidase_M50; pfam02163 756272011622 active site 756272011623 putative substrate binding region [chemical binding]; other site 756272011624 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 756272011625 HlyD family secretion protein; Region: HlyD_3; pfam13437 756272011626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011627 TPR motif; other site 756272011628 TPR repeat; Region: TPR_11; pfam13414 756272011629 binding surface 756272011630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011631 binding surface 756272011632 TPR motif; other site 756272011633 TPR repeat; Region: TPR_11; pfam13414 756272011634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011635 binding surface 756272011636 TPR motif; other site 756272011637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011638 binding surface 756272011639 TPR motif; other site 756272011640 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 756272011641 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 756272011642 Ca2+ binding site [ion binding]; other site 756272011643 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 756272011644 active site 756272011645 catalytic triad [active] 756272011646 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 756272011647 Sulfatase; Region: Sulfatase; pfam00884 756272011648 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 756272011649 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 756272011650 Asp-box motif; other site 756272011651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 756272011652 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 756272011653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272011654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272011655 ATP binding site [chemical binding]; other site 756272011656 Mg2+ binding site [ion binding]; other site 756272011657 G-X-G motif; other site 756272011658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 756272011659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272011660 active site 756272011661 phosphorylation site [posttranslational modification] 756272011662 intermolecular recognition site; other site 756272011663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 756272011664 dimerization interface [polypeptide binding]; other site 756272011665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 756272011666 dimer interface [polypeptide binding]; other site 756272011667 phosphorylation site [posttranslational modification] 756272011668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 756272011669 ATP binding site [chemical binding]; other site 756272011670 Mg2+ binding site [ion binding]; other site 756272011671 G-X-G motif; other site 756272011672 Response regulator receiver domain; Region: Response_reg; pfam00072 756272011673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 756272011674 active site 756272011675 phosphorylation site [posttranslational modification] 756272011676 intermolecular recognition site; other site 756272011677 dimerization interface [polypeptide binding]; other site 756272011678 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575 756272011679 putative ligand binding site [chemical binding]; other site 756272011680 putative catalytic site [active] 756272011681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 756272011682 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 756272011683 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 756272011684 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 756272011685 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011686 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 756272011687 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 756272011688 ApbE family; Region: ApbE; pfam02424 756272011689 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 756272011690 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 756272011691 substrate binding site [chemical binding]; other site 756272011692 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 756272011693 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 756272011694 substrate binding site [chemical binding]; other site 756272011695 ligand binding site [chemical binding]; other site 756272011696 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 756272011697 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 756272011698 putative NAD(P) binding site [chemical binding]; other site 756272011699 putative substrate binding site [chemical binding]; other site 756272011700 catalytic Zn binding site [ion binding]; other site 756272011701 structural Zn binding site [ion binding]; other site 756272011702 dimer interface [polypeptide binding]; other site 756272011703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 756272011704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 756272011705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 756272011706 dimerization interface [polypeptide binding]; other site 756272011707 Protein of unknown function (DUF1308); Region: DUF1308; pfam07000 756272011708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 756272011709 putative Zn2+ binding site [ion binding]; other site 756272011710 putative DNA binding site [nucleotide binding]; other site 756272011711 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 756272011712 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 756272011713 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 756272011714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 756272011715 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 756272011716 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 756272011717 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 756272011718 catalytic residues [active] 756272011719 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011720 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 756272011721 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 756272011722 dimer interface [polypeptide binding]; other site 756272011723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272011724 catalytic residue [active] 756272011725 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 756272011726 DinB family; Region: DinB; cl17821 756272011727 DinB superfamily; Region: DinB_2; pfam12867 756272011728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 756272011729 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 756272011730 inhibitor-cofactor binding pocket; inhibition site 756272011731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 756272011732 catalytic residue [active] 756272011733 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 756272011734 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 756272011735 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 756272011736 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011737 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 756272011738 protein binding site [polypeptide binding]; other site 756272011739 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 756272011740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 756272011741 active site 756272011742 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 756272011743 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 756272011744 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 756272011745 Domain of unknown function DUF20; Region: UPF0118; pfam01594 756272011746 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 756272011747 active site 756272011748 catalytic triad [active] 756272011749 oxyanion hole [active] 756272011750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011751 TPR motif; other site 756272011752 binding surface 756272011753 TPR repeat; Region: TPR_11; pfam13414 756272011754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011755 binding surface 756272011756 TPR motif; other site 756272011757 TPR repeat; Region: TPR_11; pfam13414 756272011758 TPR repeat; Region: TPR_11; pfam13414 756272011759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 756272011760 TPR motif; other site 756272011761 TPR repeat; Region: TPR_11; pfam13414 756272011762 binding surface 756272011763 TPR repeat; Region: TPR_11; pfam13414 756272011764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 756272011765 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 756272011766 nudix motif; other site 756272011767 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272011768 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 756272011769 HEAT repeats; Region: HEAT_2; pfam13646 756272011770 HEAT repeats; Region: HEAT_2; pfam13646 756272011771 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272011772 Cytochrome c; Region: Cytochrom_C; pfam00034 756272011773 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 756272011774 Sulfatase; Region: Sulfatase; cl17466 756272011775 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 756272011776 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 756272011777 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 756272011778 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 756272011779 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 756272011780 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 756272011781 sugar binding site [chemical binding]; other site 756272011782 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 756272011783 HEAT repeats; Region: HEAT_2; pfam13646 756272011784 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 756272011785 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 756272011786 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 756272011787 substrate binding site [chemical binding]; other site 756272011788 ATP binding site [chemical binding]; other site 756272011789 Chorismate mutase type II; Region: CM_2; smart00830 756272011790 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 756272011791 Prephenate dehydratase; Region: PDT; pfam00800 756272011792 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 756272011793 putative L-Phe binding site [chemical binding]; other site 756272011794 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 756272011795 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 756272011796 nucleotide binding site [chemical binding]; other site 756272011797 NEF interaction site [polypeptide binding]; other site 756272011798 SBD interface [polypeptide binding]; other site 756272011799 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 756272011800 Clp amino terminal domain; Region: Clp_N; pfam02861 756272011801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272011802 Walker A motif; other site 756272011803 ATP binding site [chemical binding]; other site 756272011804 Walker B motif; other site 756272011805 arginine finger; other site 756272011806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 756272011807 Walker A motif; other site 756272011808 ATP binding site [chemical binding]; other site 756272011809 Walker B motif; other site 756272011810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 756272011811 Predicted metalloprotease [General function prediction only]; Region: COG2321 756272011812 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 756272011813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 756272011814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 756272011815 putative substrate translocation pore; other site 756272011816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 756272011817 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 756272011818 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 756272011819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 756272011820 Walker A/P-loop; other site 756272011821 ATP binding site [chemical binding]; other site 756272011822 Q-loop/lid; other site 756272011823 ABC transporter signature motif; other site 756272011824 Walker B; other site 756272011825 D-loop; other site 756272011826 H-loop/switch region; other site 756272011827 carboxy-terminal protease; Provisional; Region: PRK11186 756272011828 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 756272011829 protein binding site [polypeptide binding]; other site 756272011830 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 756272011831 Catalytic dyad [active] 756272011832 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 756272011833 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 756272011834 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 756272011835 ATP-grasp domain; Region: ATP-grasp_4; cl17255 756272011836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 756272011837 Acetyltransferases [General function prediction only]; Region: RimI; COG0456