-- dump date 20140619_234355 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521674000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 521674000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674000003 AAA domain; Region: AAA_22; pfam13401 521674000004 Walker A motif; other site 521674000005 ATP binding site [chemical binding]; other site 521674000006 Walker B motif; other site 521674000007 arginine finger; other site 521674000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521674000009 DnaA box-binding interface [nucleotide binding]; other site 521674000010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674000011 HAMP domain; Region: HAMP; pfam00672 521674000012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674000013 dimer interface [polypeptide binding]; other site 521674000014 phosphorylation site [posttranslational modification] 521674000015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674000016 ATP binding site [chemical binding]; other site 521674000017 Mg2+ binding site [ion binding]; other site 521674000018 G-X-G motif; other site 521674000019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521674000020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674000021 active site 521674000022 phosphorylation site [posttranslational modification] 521674000023 intermolecular recognition site; other site 521674000024 dimerization interface [polypeptide binding]; other site 521674000025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521674000026 DNA binding site [nucleotide binding] 521674000027 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674000028 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674000029 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674000030 Ferredoxin [Energy production and conversion]; Region: COG1146 521674000031 4Fe-4S binding domain; Region: Fer4; cl02805 521674000032 ECF sigma factor; Region: Sigma70_ECF; pfam07638 521674000033 Protein kinase domain; Region: Pkinase; pfam00069 521674000034 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674000035 active site 521674000036 ATP binding site [chemical binding]; other site 521674000037 substrate binding site [chemical binding]; other site 521674000038 activation loop (A-loop); other site 521674000039 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521674000040 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 521674000041 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674000042 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521674000043 FAD binding domain; Region: FAD_binding_4; pfam01565 521674000044 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521674000045 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 521674000046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674000047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674000048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674000049 dimerization interface [polypeptide binding]; other site 521674000050 putative DNA binding site [nucleotide binding]; other site 521674000051 putative Zn2+ binding site [ion binding]; other site 521674000052 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 521674000053 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 521674000054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674000055 Zn2+ binding site [ion binding]; other site 521674000056 Mg2+ binding site [ion binding]; other site 521674000057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674000058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521674000059 dimerization interface [polypeptide binding]; other site 521674000060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674000061 dimer interface [polypeptide binding]; other site 521674000062 phosphorylation site [posttranslational modification] 521674000063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674000064 ATP binding site [chemical binding]; other site 521674000065 Mg2+ binding site [ion binding]; other site 521674000066 G-X-G motif; other site 521674000067 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 521674000068 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674000069 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 521674000070 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 521674000071 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 521674000072 putative rRNA binding site [nucleotide binding]; other site 521674000073 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 521674000074 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 521674000075 dimer interface [polypeptide binding]; other site 521674000076 motif 1; other site 521674000077 active site 521674000078 motif 2; other site 521674000079 motif 3; other site 521674000080 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521674000081 anticodon binding site; other site 521674000082 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 521674000083 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000084 NPCBM/NEW2 domain; Region: NPCBM; cl07060 521674000085 NPCBM/NEW2 domain; Region: NPCBM; cl07060 521674000086 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674000087 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 521674000088 HEAT repeats; Region: HEAT_2; pfam13646 521674000089 HEAT repeats; Region: HEAT_2; pfam13646 521674000090 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674000091 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521674000092 Putative zinc ribbon domain; Region: DUF164; pfam02591 521674000093 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000094 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000095 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 521674000096 conserved cys residue [active] 521674000097 N-formylglutamate amidohydrolase; Region: FGase; cl01522 521674000098 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521674000099 DNA polymerase III subunit beta; Validated; Region: PRK05643 521674000100 putative DNA binding surface [nucleotide binding]; other site 521674000101 dimer interface [polypeptide binding]; other site 521674000102 beta-clamp/clamp loader binding surface; other site 521674000103 beta-clamp/translesion DNA polymerase binding surface; other site 521674000104 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674000105 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674000106 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674000107 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 521674000108 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674000109 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 521674000110 active site 521674000111 catalytic site [active] 521674000112 substrate binding site [chemical binding]; other site 521674000113 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 521674000114 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 521674000115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674000116 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 521674000117 putative active site [active] 521674000118 putative metal binding site [ion binding]; other site 521674000119 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674000120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674000121 S-adenosylmethionine binding site [chemical binding]; other site 521674000122 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674000123 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674000124 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 521674000125 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 521674000126 active site 521674000127 dimer interface [polypeptide binding]; other site 521674000128 metal binding site [ion binding]; metal-binding site 521674000129 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521674000130 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 521674000131 DNA protecting protein DprA; Region: dprA; TIGR00732 521674000132 Repair protein; Region: Repair_PSII; pfam04536 521674000133 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674000134 metal ion-dependent adhesion site (MIDAS); other site 521674000135 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 521674000136 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 521674000137 glutamine binding [chemical binding]; other site 521674000138 catalytic triad [active] 521674000139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521674000140 RNA binding surface [nucleotide binding]; other site 521674000141 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 521674000142 IHF dimer interface [polypeptide binding]; other site 521674000143 IHF - DNA interface [nucleotide binding]; other site 521674000144 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674000145 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674000146 phosphopeptide binding site; other site 521674000147 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 521674000148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674000149 S-adenosylmethionine binding site [chemical binding]; other site 521674000150 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 521674000151 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 521674000152 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 521674000153 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 521674000154 AIR carboxylase; Region: AIRC; smart01001 521674000155 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521674000156 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521674000157 active site 521674000158 ADP/pyrophosphate binding site [chemical binding]; other site 521674000159 dimerization interface [polypeptide binding]; other site 521674000160 allosteric effector site; other site 521674000161 fructose-1,6-bisphosphate binding site; other site 521674000162 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 521674000163 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521674000164 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 521674000165 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 521674000166 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 521674000167 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521674000168 carboxyltransferase (CT) interaction site; other site 521674000169 biotinylation site [posttranslational modification]; other site 521674000170 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521674000171 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521674000172 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 521674000173 active site 521674000174 MMPL family; Region: MMPL; pfam03176 521674000175 FtsH Extracellular; Region: FtsH_ext; pfam06480 521674000176 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521674000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674000178 Walker A motif; other site 521674000179 ATP binding site [chemical binding]; other site 521674000180 Walker B motif; other site 521674000181 arginine finger; other site 521674000182 Peptidase family M41; Region: Peptidase_M41; pfam01434 521674000183 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 521674000184 Double zinc ribbon; Region: DZR; pfam12773 521674000185 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 521674000186 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521674000187 transmembrane helices; other site 521674000188 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521674000189 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521674000190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674000191 Walker A/P-loop; other site 521674000192 ATP binding site [chemical binding]; other site 521674000193 Q-loop/lid; other site 521674000194 ABC transporter signature motif; other site 521674000195 Walker B; other site 521674000196 D-loop; other site 521674000197 H-loop/switch region; other site 521674000198 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 521674000199 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000200 urease subunit alpha; Reviewed; Region: ureC; PRK13207 521674000201 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 521674000202 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 521674000203 Cell division protein FtsA; Region: FtsA; pfam14450 521674000204 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 521674000205 isocitrate dehydrogenase; Validated; Region: PRK06451 521674000206 PSP1 C-terminal conserved region; Region: PSP1; cl00770 521674000207 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 521674000208 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521674000209 active site 521674000210 (T/H)XGH motif; other site 521674000211 Type II/IV secretion system protein; Region: T2SE; pfam00437 521674000212 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521674000213 Walker A motif; other site 521674000214 ATP binding site [chemical binding]; other site 521674000215 Walker B motif; other site 521674000216 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674000217 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000218 Uncharacterized conserved protein [Function unknown]; Region: COG3350 521674000219 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 521674000220 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521674000221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674000222 motif II; other site 521674000223 NIPSNAP; Region: NIPSNAP; pfam07978 521674000224 Outer membrane efflux protein; Region: OEP; pfam02321 521674000225 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521674000226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521674000227 metal binding site [ion binding]; metal-binding site 521674000228 active site 521674000229 I-site; other site 521674000230 2-isopropylmalate synthase; Validated; Region: PRK00915 521674000231 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 521674000232 active site 521674000233 catalytic residues [active] 521674000234 metal binding site [ion binding]; metal-binding site 521674000235 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 521674000236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674000237 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 521674000238 dimer interface [polypeptide binding]; other site 521674000239 putative metal binding site [ion binding]; other site 521674000240 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 521674000241 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521674000242 putative active site [active] 521674000243 FtsX-like permease family; Region: FtsX; pfam02687 521674000244 FtsX-like permease family; Region: FtsX; pfam02687 521674000245 hydroxyglutarate oxidase; Provisional; Region: PRK11728 521674000246 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 521674000247 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 521674000248 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521674000249 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 521674000250 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 521674000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674000252 Mg2+ binding site [ion binding]; other site 521674000253 G-X-G motif; other site 521674000254 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521674000255 anchoring element; other site 521674000256 dimer interface [polypeptide binding]; other site 521674000257 ATP binding site [chemical binding]; other site 521674000258 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 521674000259 active site 521674000260 metal binding site [ion binding]; metal-binding site 521674000261 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521674000262 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 521674000263 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521674000264 CAP-like domain; other site 521674000265 active site 521674000266 primary dimer interface [polypeptide binding]; other site 521674000267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674000268 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674000269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674000270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674000271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 521674000272 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674000273 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674000274 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 521674000275 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 521674000276 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 521674000277 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521674000278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674000279 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 521674000280 PAS fold; Region: PAS_4; pfam08448 521674000281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000282 putative active site [active] 521674000283 heme pocket [chemical binding]; other site 521674000284 PAS fold; Region: PAS_3; pfam08447 521674000285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000286 putative active site [active] 521674000287 heme pocket [chemical binding]; other site 521674000288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000289 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674000290 putative active site [active] 521674000291 heme pocket [chemical binding]; other site 521674000292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000293 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674000294 putative active site [active] 521674000295 heme pocket [chemical binding]; other site 521674000296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000297 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674000298 putative active site [active] 521674000299 heme pocket [chemical binding]; other site 521674000300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000301 putative active site [active] 521674000302 heme pocket [chemical binding]; other site 521674000303 PAS fold; Region: PAS_4; pfam08448 521674000304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000305 putative active site [active] 521674000306 heme pocket [chemical binding]; other site 521674000307 PAS domain; Region: PAS_9; pfam13426 521674000308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674000309 putative active site [active] 521674000310 heme pocket [chemical binding]; other site 521674000311 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521674000312 PAS domain; Region: PAS; smart00091 521674000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674000314 dimer interface [polypeptide binding]; other site 521674000315 phosphorylation site [posttranslational modification] 521674000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674000317 ATP binding site [chemical binding]; other site 521674000318 Mg2+ binding site [ion binding]; other site 521674000319 G-X-G motif; other site 521674000320 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674000321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674000322 active site 521674000323 phosphorylation site [posttranslational modification] 521674000324 intermolecular recognition site; other site 521674000325 dimerization interface [polypeptide binding]; other site 521674000326 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674000327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521674000328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 521674000329 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521674000330 DinB superfamily; Region: DinB_2; pfam12867 521674000331 metal-dependent hydrolase; Provisional; Region: PRK13291 521674000332 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521674000333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674000334 FtsX-like permease family; Region: FtsX; pfam02687 521674000335 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674000336 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 521674000337 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674000338 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674000339 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674000340 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 521674000341 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 521674000342 trimer interface [polypeptide binding]; other site 521674000343 dimer interface [polypeptide binding]; other site 521674000344 putative active site [active] 521674000345 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 521674000346 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 521674000347 phosphate binding site [ion binding]; other site 521674000348 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 521674000349 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 521674000350 aspartate aminotransferase; Provisional; Region: PRK05764 521674000351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674000352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674000353 homodimer interface [polypeptide binding]; other site 521674000354 catalytic residue [active] 521674000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674000356 putative substrate translocation pore; other site 521674000357 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 521674000358 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521674000359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674000360 Walker A motif; other site 521674000361 ATP binding site [chemical binding]; other site 521674000362 Walker B motif; other site 521674000363 arginine finger; other site 521674000364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674000365 HEAT repeats; Region: HEAT_2; pfam13646 521674000366 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 521674000367 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674000368 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674000369 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 521674000370 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 521674000371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674000372 FeS/SAM binding site; other site 521674000373 HemN C-terminal domain; Region: HemN_C; pfam06969 521674000374 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 521674000375 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 521674000376 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 521674000377 Carbon starvation protein CstA; Region: CstA; pfam02554 521674000378 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 521674000379 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521674000380 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521674000381 substrate binding pocket [chemical binding]; other site 521674000382 chain length determination region; other site 521674000383 substrate-Mg2+ binding site; other site 521674000384 catalytic residues [active] 521674000385 aspartate-rich region 1; other site 521674000386 active site lid residues [active] 521674000387 aspartate-rich region 2; other site 521674000388 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 521674000389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521674000390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674000391 anti sigma factor interaction site; other site 521674000392 regulatory phosphorylation site [posttranslational modification]; other site 521674000393 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 521674000394 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521674000395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000397 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 521674000398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674000399 motif II; other site 521674000400 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 521674000401 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 521674000402 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521674000403 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521674000404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674000405 Walker A motif; other site 521674000406 ATP binding site [chemical binding]; other site 521674000407 Walker B motif; other site 521674000408 arginine finger; other site 521674000409 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521674000410 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000411 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000412 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000413 GMP synthase; Reviewed; Region: guaA; PRK00074 521674000414 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521674000415 AMP/PPi binding site [chemical binding]; other site 521674000416 candidate oxyanion hole; other site 521674000417 catalytic triad [active] 521674000418 potential glutamine specificity residues [chemical binding]; other site 521674000419 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521674000420 ATP Binding subdomain [chemical binding]; other site 521674000421 Ligand Binding sites [chemical binding]; other site 521674000422 Dimerization subdomain; other site 521674000423 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674000424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 521674000425 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 521674000426 ATP synthase A chain; Region: ATP-synt_A; cl00413 521674000427 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 521674000428 ATP synthase subunit C; Region: ATP-synt_C; cl00466 521674000429 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 521674000430 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 521674000431 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 521674000432 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 521674000433 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 521674000434 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521674000435 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 521674000436 beta subunit interaction interface [polypeptide binding]; other site 521674000437 Walker A motif; other site 521674000438 ATP binding site [chemical binding]; other site 521674000439 Walker B motif; other site 521674000440 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521674000441 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 521674000442 core domain interface [polypeptide binding]; other site 521674000443 delta subunit interface [polypeptide binding]; other site 521674000444 epsilon subunit interface [polypeptide binding]; other site 521674000445 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 521674000446 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521674000447 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 521674000448 alpha subunit interaction interface [polypeptide binding]; other site 521674000449 Walker A motif; other site 521674000450 ATP binding site [chemical binding]; other site 521674000451 Walker B motif; other site 521674000452 inhibitor binding site; inhibition site 521674000453 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521674000454 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 521674000455 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 521674000456 gamma subunit interface [polypeptide binding]; other site 521674000457 epsilon subunit interface [polypeptide binding]; other site 521674000458 LBP interface [polypeptide binding]; other site 521674000459 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 521674000460 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 521674000461 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 521674000462 signal recognition particle protein; Provisional; Region: PRK10867 521674000463 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 521674000464 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521674000465 P loop; other site 521674000466 GTP binding site [chemical binding]; other site 521674000467 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521674000468 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 521674000469 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 521674000470 P loop; other site 521674000471 Nucleotide binding site [chemical binding]; other site 521674000472 DTAP/Switch II; other site 521674000473 Switch I; other site 521674000474 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 521674000475 DTAP/Switch II; other site 521674000476 Switch I; other site 521674000477 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 521674000478 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521674000479 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521674000480 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 521674000481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674000482 S-adenosylmethionine binding site [chemical binding]; other site 521674000483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521674000484 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674000485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521674000486 Magnesium ion binding site [ion binding]; other site 521674000487 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 521674000488 DEAD/DEAH box helicase; Region: DEAD; pfam00270 521674000489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674000490 nucleotide binding region [chemical binding]; other site 521674000491 helicase superfamily c-terminal domain; Region: HELICc2; smart00491 521674000492 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674000493 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 521674000494 active site 521674000495 cosubstrate binding site; other site 521674000496 substrate binding site [chemical binding]; other site 521674000497 catalytic site [active] 521674000498 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 521674000499 putative active site [active] 521674000500 Zn binding site [ion binding]; other site 521674000501 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 521674000502 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 521674000503 dimerization interface [polypeptide binding]; other site 521674000504 active site 521674000505 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 521674000506 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 521674000507 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 521674000508 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 521674000509 GAF domain; Region: GAF_3; pfam13492 521674000510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674000511 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521674000512 Walker A motif; other site 521674000513 ATP binding site [chemical binding]; other site 521674000514 Walker B motif; other site 521674000515 arginine finger; other site 521674000516 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674000517 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 521674000518 Maf-like protein; Region: Maf; pfam02545 521674000519 putative active site [active] 521674000520 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 521674000521 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521674000522 FMN binding site [chemical binding]; other site 521674000523 active site 521674000524 catalytic residues [active] 521674000525 substrate binding site [chemical binding]; other site 521674000526 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 521674000527 Fe-S cluster binding site [ion binding]; other site 521674000528 active site 521674000529 lysophospholipid transporter LplT; Provisional; Region: PRK11195 521674000530 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 521674000531 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674000532 putative catalytic residue [active] 521674000533 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521674000534 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521674000535 active site 521674000536 homodimer interface [polypeptide binding]; other site 521674000537 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674000538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674000539 NAD(P) binding site [chemical binding]; other site 521674000540 active site 521674000541 PilZ domain; Region: PilZ; pfam07238 521674000542 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674000543 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674000544 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674000545 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 521674000546 HEAT repeats; Region: HEAT_2; pfam13646 521674000547 protein binding surface [polypeptide binding]; other site 521674000548 CHC2 zinc finger; Region: zf-CHC2; cl17510 521674000549 DNA primase; Validated; Region: dnaG; PRK05667 521674000550 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521674000551 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521674000552 active site 521674000553 metal binding site [ion binding]; metal-binding site 521674000554 interdomain interaction site; other site 521674000555 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 521674000556 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 521674000557 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521674000558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674000559 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521674000560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674000561 DNA binding residues [nucleotide binding] 521674000562 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521674000563 ABC-2 type transporter; Region: ABC2_membrane; cl17235 521674000564 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 521674000565 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 521674000566 Cu(I) binding site [ion binding]; other site 521674000567 Protein of unknown function (DUF420); Region: DUF420; pfam04238 521674000568 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674000569 Trp docking motif [polypeptide binding]; other site 521674000570 PQQ-like domain; Region: PQQ_2; pfam13360 521674000571 active site 521674000572 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674000573 metal ion-dependent adhesion site (MIDAS); other site 521674000574 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 521674000575 TadE-like protein; Region: TadE; pfam07811 521674000576 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 521674000577 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521674000578 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674000579 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674000580 active site 521674000581 ATP binding site [chemical binding]; other site 521674000582 substrate binding site [chemical binding]; other site 521674000583 activation loop (A-loop); other site 521674000584 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674000585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674000586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 521674000587 DNA binding residues [nucleotide binding] 521674000588 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 521674000589 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 521674000590 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 521674000591 ribonuclease III; Reviewed; Region: rnc; PRK00102 521674000592 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521674000593 dimerization interface [polypeptide binding]; other site 521674000594 active site 521674000595 metal binding site [ion binding]; metal-binding site 521674000596 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521674000597 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 521674000598 Fe-S metabolism associated domain; Region: SufE; cl00951 521674000599 PQQ-like domain; Region: PQQ_2; pfam13360 521674000600 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674000601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674000602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 521674000603 DNA binding residues [nucleotide binding] 521674000604 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 521674000605 Serine hydrolase (FSH1); Region: FSH1; pfam03959 521674000606 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674000607 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674000608 phosphopeptide binding site; other site 521674000609 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674000610 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 521674000611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674000612 ATP binding site [chemical binding]; other site 521674000613 Mg2+ binding site [ion binding]; other site 521674000614 G-X-G motif; other site 521674000615 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 521674000616 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674000617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674000618 TPR motif; other site 521674000619 binding surface 521674000620 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521674000621 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521674000622 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521674000623 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521674000624 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521674000625 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674000626 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521674000627 catalytic residues [active] 521674000628 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 521674000629 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 521674000630 Permutation of conserved domain; other site 521674000631 active site 521674000632 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 521674000633 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521674000634 active site 521674000635 catalytic residues [active] 521674000636 metal binding site [ion binding]; metal-binding site 521674000637 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 521674000638 thiS-thiF/thiG interaction site; other site 521674000639 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 521674000640 active site 521674000641 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674000642 active site 521674000643 PQQ-like domain; Region: PQQ_2; pfam13360 521674000644 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674000645 Trp docking motif [polypeptide binding]; other site 521674000646 active site 521674000647 Alpha C protein N terminal; Region: AlphaC_N; pfam08829 521674000648 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 521674000649 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 521674000650 Uncharacterized conserved protein [Function unknown]; Region: COG0432 521674000651 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521674000652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521674000653 Walker A/P-loop; other site 521674000654 ATP binding site [chemical binding]; other site 521674000655 Q-loop/lid; other site 521674000656 ABC transporter signature motif; other site 521674000657 Walker B; other site 521674000658 D-loop; other site 521674000659 H-loop/switch region; other site 521674000660 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 521674000661 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674000662 Trp docking motif [polypeptide binding]; other site 521674000663 PQQ-like domain; Region: PQQ_2; pfam13360 521674000664 active site 521674000665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521674000666 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 521674000667 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 521674000668 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521674000669 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521674000670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674000671 motif II; other site 521674000672 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521674000673 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521674000674 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 521674000675 catalytic residue [active] 521674000676 putative FPP diphosphate binding site; other site 521674000677 putative FPP binding hydrophobic cleft; other site 521674000678 dimer interface [polypeptide binding]; other site 521674000679 putative IPP diphosphate binding site; other site 521674000680 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 521674000681 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 521674000682 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 521674000683 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 521674000684 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 521674000685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674000686 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 521674000687 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 521674000688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674000689 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 521674000690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674000691 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 521674000692 HEAT repeats; Region: HEAT_2; pfam13646 521674000693 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 521674000694 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521674000695 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674000696 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 521674000697 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674000698 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 521674000699 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674000700 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 521674000701 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674000702 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674000703 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 521674000704 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674000705 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674000706 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674000707 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 521674000708 photolyase PhrII; Region: phr2; TIGR00591 521674000709 DNA photolyase; Region: DNA_photolyase; pfam00875 521674000710 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 521674000711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674000712 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674000713 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 521674000714 agmatinase; Region: agmatinase; TIGR01230 521674000715 oligomer interface [polypeptide binding]; other site 521674000716 putative active site [active] 521674000717 Mn binding site [ion binding]; other site 521674000718 AAA domain; Region: AAA_13; pfam13166 521674000719 dihydroorotase; Provisional; Region: PRK07575 521674000720 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 521674000721 active site 521674000722 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 521674000723 A new structural DNA glycosylase; Region: AlkD_like; cd06561 521674000724 active site 521674000725 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 521674000726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521674000727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521674000728 active site 521674000729 catalytic tetrad [active] 521674000730 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521674000731 classical (c) SDRs; Region: SDR_c; cd05233 521674000732 NAD(P) binding site [chemical binding]; other site 521674000733 active site 521674000734 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674000735 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000736 DNA polymerase IV; Reviewed; Region: PRK03103 521674000737 Y-family of DNA polymerases; Region: PolY; cd00424 521674000738 active site 521674000739 DNA binding site [nucleotide binding] 521674000740 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 521674000741 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 521674000742 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674000743 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674000744 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 521674000745 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 521674000746 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 521674000747 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 521674000748 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 521674000749 active site 521674000750 Zn binding site [ion binding]; other site 521674000751 Global regulator protein family; Region: CsrA; pfam02599 521674000752 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 521674000753 ligand-binding site [chemical binding]; other site 521674000754 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 521674000755 RNA polymerase sigma factor; Provisional; Region: PRK12513 521674000756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674000757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674000758 DNA binding residues [nucleotide binding] 521674000759 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 521674000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674000761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674000762 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 521674000763 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 521674000764 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 521674000765 substrate binding site [chemical binding]; other site 521674000766 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521674000767 putative active site [active] 521674000768 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 521674000769 substrate binding site [chemical binding]; other site 521674000770 ligand binding site [chemical binding]; other site 521674000771 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521674000772 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521674000773 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674000774 dimerization interface [polypeptide binding]; other site 521674000775 putative DNA binding site [nucleotide binding]; other site 521674000776 putative Zn2+ binding site [ion binding]; other site 521674000777 Protein of unknown function (DUF423); Region: DUF423; pfam04241 521674000778 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 521674000779 intracellular protease, PfpI family; Region: PfpI; TIGR01382 521674000780 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 521674000781 conserved cys residue [active] 521674000782 cytidylate kinase; Provisional; Region: cmk; PRK00023 521674000783 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521674000784 CMP-binding site; other site 521674000785 The sites determining sugar specificity; other site 521674000786 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521674000787 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 521674000788 active site 521674000789 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 521674000790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674000791 Zn2+ binding site [ion binding]; other site 521674000792 Mg2+ binding site [ion binding]; other site 521674000793 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 521674000794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521674000795 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 521674000796 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 521674000797 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521674000798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674000799 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 521674000800 IMP binding site; other site 521674000801 dimer interface [polypeptide binding]; other site 521674000802 interdomain contacts; other site 521674000803 partial ornithine binding site; other site 521674000804 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674000805 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674000806 putative acetyltransferase; Provisional; Region: PRK03624 521674000807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674000808 Coenzyme A binding pocket [chemical binding]; other site 521674000809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674000810 Coenzyme A binding pocket [chemical binding]; other site 521674000811 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521674000812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521674000813 PYR/PP interface [polypeptide binding]; other site 521674000814 dimer interface [polypeptide binding]; other site 521674000815 TPP binding site [chemical binding]; other site 521674000816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521674000817 transketolase; Reviewed; Region: PRK05899 521674000818 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521674000819 TPP-binding site [chemical binding]; other site 521674000820 dimer interface [polypeptide binding]; other site 521674000821 Global regulator protein family; Region: CsrA; pfam02599 521674000822 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 521674000823 putative active site [active] 521674000824 Zn binding site [ion binding]; other site 521674000825 Divergent AAA domain; Region: AAA_4; pfam04326 521674000826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521674000827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674000828 active site 521674000829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 521674000830 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521674000831 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 521674000832 active site 521674000833 catalytic triad [active] 521674000834 oxyanion hole [active] 521674000835 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674000836 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 521674000837 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674000838 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674000839 Sulfatase; Region: Sulfatase; pfam00884 521674000840 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 521674000841 putative active site [active] 521674000842 putative metal binding site [ion binding]; other site 521674000843 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 521674000844 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 521674000845 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 521674000846 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 521674000847 homodimer interface [polypeptide binding]; other site 521674000848 oligonucleotide binding site [chemical binding]; other site 521674000849 Ribonuclease P; Region: Ribonuclease_P; cl00457 521674000850 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 521674000851 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521674000852 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521674000853 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521674000854 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521674000855 dimerization domain swap beta strand [polypeptide binding]; other site 521674000856 regulatory protein interface [polypeptide binding]; other site 521674000857 active site 521674000858 regulatory phosphorylation site [posttranslational modification]; other site 521674000859 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521674000860 active site 521674000861 phosphorylation site [posttranslational modification] 521674000862 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 521674000863 30S subunit binding site; other site 521674000864 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 521674000865 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 521674000866 putative NAD(P) binding site [chemical binding]; other site 521674000867 active site 521674000868 putative substrate binding site [chemical binding]; other site 521674000869 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 521674000870 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521674000871 Peptidase family M50; Region: Peptidase_M50; pfam02163 521674000872 active site 521674000873 putative substrate binding region [chemical binding]; other site 521674000874 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674000875 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674000876 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 521674000877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674000878 ATP binding site [chemical binding]; other site 521674000879 putative Mg++ binding site [ion binding]; other site 521674000880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674000881 nucleotide binding region [chemical binding]; other site 521674000882 ATP-binding site [chemical binding]; other site 521674000883 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 521674000884 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 521674000885 Active Sites [active] 521674000886 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 521674000887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674000888 S-adenosylmethionine binding site [chemical binding]; other site 521674000889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521674000890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674000891 active site 521674000892 phosphorylation site [posttranslational modification] 521674000893 intermolecular recognition site; other site 521674000894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521674000895 DNA binding residues [nucleotide binding] 521674000896 dimerization interface [polypeptide binding]; other site 521674000897 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521674000898 Histidine kinase; Region: HisKA_3; pfam07730 521674000899 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 521674000900 ATP binding site [chemical binding]; other site 521674000901 Mg2+ binding site [ion binding]; other site 521674000902 G-X-G motif; other site 521674000903 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000904 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 521674000905 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000906 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674000907 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674000908 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674000909 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674000910 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521674000911 16S/18S rRNA binding site [nucleotide binding]; other site 521674000912 S13e-L30e interaction site [polypeptide binding]; other site 521674000913 25S rRNA binding site [nucleotide binding]; other site 521674000914 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521674000915 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521674000916 RNase E interface [polypeptide binding]; other site 521674000917 trimer interface [polypeptide binding]; other site 521674000918 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521674000919 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521674000920 RNase E interface [polypeptide binding]; other site 521674000921 trimer interface [polypeptide binding]; other site 521674000922 active site 521674000923 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521674000924 putative nucleic acid binding region [nucleotide binding]; other site 521674000925 G-X-X-G motif; other site 521674000926 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521674000927 RNA binding site [nucleotide binding]; other site 521674000928 domain interface; other site 521674000929 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674000930 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 521674000931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674000932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674000933 DNA binding residues [nucleotide binding] 521674000934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674000935 Coenzyme A binding pocket [chemical binding]; other site 521674000936 endonuclease IV; Provisional; Region: PRK01060 521674000937 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 521674000938 AP (apurinic/apyrimidinic) site pocket; other site 521674000939 DNA interaction; other site 521674000940 Metal-binding active site; metal-binding site 521674000941 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 521674000942 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674000943 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674000944 Domain of unknown function DUF59; Region: DUF59; pfam01883 521674000945 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521674000946 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 521674000947 Walker A motif; other site 521674000948 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 521674000949 putative NAD(P) binding site [chemical binding]; other site 521674000950 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 521674000951 conserved repeat domain; Region: B_ant_repeat; TIGR01451 521674000952 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 521674000953 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521674000954 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000955 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000956 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 521674000957 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521674000958 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521674000959 Walker A motif; other site 521674000960 ATP binding site [chemical binding]; other site 521674000961 Walker B motif; other site 521674000962 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 521674000963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674000964 Walker A motif; other site 521674000965 ATP binding site [chemical binding]; other site 521674000966 Walker B motif; other site 521674000967 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521674000968 type II secretion system protein E; Region: type_II_gspE; TIGR02533 521674000969 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521674000970 Walker A motif; other site 521674000971 ATP binding site [chemical binding]; other site 521674000972 Walker B motif; other site 521674000973 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 521674000974 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 521674000975 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 521674000976 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 521674000977 catalytic site [active] 521674000978 active site 521674000979 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 521674000980 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 521674000981 CsbD-like; Region: CsbD; cl17424 521674000982 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 521674000983 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521674000984 DHH family; Region: DHH; pfam01368 521674000985 DHHA1 domain; Region: DHHA1; pfam02272 521674000986 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 521674000987 iron-sulfur cluster [ion binding]; other site 521674000988 [2Fe-2S] cluster binding site [ion binding]; other site 521674000989 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 521674000990 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 521674000991 heme bH binding site [chemical binding]; other site 521674000992 intrachain domain interface; other site 521674000993 heme bL binding site [chemical binding]; other site 521674000994 interchain domain interface [polypeptide binding]; other site 521674000995 Qo binding site; other site 521674000996 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521674000997 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000998 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674000999 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 521674001000 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521674001001 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521674001002 Walker A motif; other site 521674001003 ATP binding site [chemical binding]; other site 521674001004 Walker B motif; other site 521674001005 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674001006 anti sigma factor interaction site; other site 521674001007 regulatory phosphorylation site [posttranslational modification]; other site 521674001008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674001009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001010 active site 521674001011 phosphorylation site [posttranslational modification] 521674001012 intermolecular recognition site; other site 521674001013 dimerization interface [polypeptide binding]; other site 521674001014 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521674001015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674001016 dimer interface [polypeptide binding]; other site 521674001017 phosphorylation site [posttranslational modification] 521674001018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674001019 ATP binding site [chemical binding]; other site 521674001020 Mg2+ binding site [ion binding]; other site 521674001021 G-X-G motif; other site 521674001022 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 521674001023 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 521674001024 generic binding surface II; other site 521674001025 generic binding surface I; other site 521674001026 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 521674001027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001028 TPR motif; other site 521674001029 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674001030 binding surface 521674001031 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674001032 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674001033 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674001034 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 521674001035 active site 521674001036 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521674001037 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521674001038 Catalytic site [active] 521674001039 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521674001040 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521674001041 elongation factor Tu; Reviewed; Region: PRK12735 521674001042 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521674001043 G1 box; other site 521674001044 GEF interaction site [polypeptide binding]; other site 521674001045 GTP/Mg2+ binding site [chemical binding]; other site 521674001046 Switch I region; other site 521674001047 G2 box; other site 521674001048 G3 box; other site 521674001049 Switch II region; other site 521674001050 G4 box; other site 521674001051 G5 box; other site 521674001052 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521674001053 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521674001054 Antibiotic Binding Site [chemical binding]; other site 521674001055 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 521674001056 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 521674001057 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 521674001058 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521674001059 putative homodimer interface [polypeptide binding]; other site 521674001060 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 521674001061 heterodimer interface [polypeptide binding]; other site 521674001062 homodimer interface [polypeptide binding]; other site 521674001063 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521674001064 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521674001065 23S rRNA interface [nucleotide binding]; other site 521674001066 L7/L12 interface [polypeptide binding]; other site 521674001067 putative thiostrepton binding site; other site 521674001068 L25 interface [polypeptide binding]; other site 521674001069 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521674001070 mRNA/rRNA interface [nucleotide binding]; other site 521674001071 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521674001072 23S rRNA interface [nucleotide binding]; other site 521674001073 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521674001074 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521674001075 peripheral dimer interface [polypeptide binding]; other site 521674001076 core dimer interface [polypeptide binding]; other site 521674001077 L10 interface [polypeptide binding]; other site 521674001078 L11 interface [polypeptide binding]; other site 521674001079 putative EF-Tu interaction site [polypeptide binding]; other site 521674001080 putative EF-G interaction site [polypeptide binding]; other site 521674001081 DNA-directed RNA polymerase subunit B''; Validated; Region: PRK09606 521674001082 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 521674001083 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 521674001084 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521674001085 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 521674001086 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521674001087 RPB3 interaction site [polypeptide binding]; other site 521674001088 RPB1 interaction site [polypeptide binding]; other site 521674001089 RPB11 interaction site [polypeptide binding]; other site 521674001090 RPB10 interaction site [polypeptide binding]; other site 521674001091 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 521674001092 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 521674001093 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 521674001094 Ligand binding site; other site 521674001095 Putative Catalytic site; other site 521674001096 DXD motif; other site 521674001097 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 521674001098 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 521674001099 putative active site [active] 521674001100 catalytic site [active] 521674001101 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 521674001102 putative active site [active] 521674001103 catalytic site [active] 521674001104 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 521674001105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001106 Walker A motif; other site 521674001107 ATP binding site [chemical binding]; other site 521674001108 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 521674001109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674001110 Mg2+ binding site [ion binding]; other site 521674001111 G-X-G motif; other site 521674001112 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521674001113 anchoring element; other site 521674001114 dimer interface [polypeptide binding]; other site 521674001115 ATP binding site [chemical binding]; other site 521674001116 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 521674001117 active site 521674001118 putative metal-binding site [ion binding]; other site 521674001119 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521674001120 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521674001121 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521674001122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674001123 active site 521674001124 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 521674001125 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521674001126 catalytic residue [active] 521674001127 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674001128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674001129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674001130 DNA binding residues [nucleotide binding] 521674001131 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 521674001132 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 521674001133 Leishmanolysin; Region: Peptidase_M8; pfam01457 521674001134 active site 521674001135 Right handed beta helix region; Region: Beta_helix; pfam13229 521674001136 Response regulator receiver domain; Region: Response_reg; pfam00072 521674001137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001138 active site 521674001139 phosphorylation site [posttranslational modification] 521674001140 intermolecular recognition site; other site 521674001141 dimerization interface [polypeptide binding]; other site 521674001142 hypothetical protein; Reviewed; Region: PRK12497 521674001143 Global regulator protein family; Region: CsrA; cl00670 521674001144 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 521674001145 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521674001146 active site 521674001147 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 521674001148 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521674001149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 521674001150 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 521674001151 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 521674001152 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 521674001153 putative NADP binding site [chemical binding]; other site 521674001154 active site 521674001155 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 521674001156 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 521674001157 FMN binding site [chemical binding]; other site 521674001158 substrate binding site [chemical binding]; other site 521674001159 putative catalytic residue [active] 521674001160 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 521674001161 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 521674001162 malonyl-CoA binding site [chemical binding]; other site 521674001163 dimer interface [polypeptide binding]; other site 521674001164 active site 521674001165 product binding site; other site 521674001166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521674001167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521674001168 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 521674001169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674001170 FtsX-like permease family; Region: FtsX; pfam02687 521674001171 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674001172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674001173 Walker A/P-loop; other site 521674001174 ATP binding site [chemical binding]; other site 521674001175 Q-loop/lid; other site 521674001176 ABC transporter signature motif; other site 521674001177 Walker B; other site 521674001178 D-loop; other site 521674001179 H-loop/switch region; other site 521674001180 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521674001181 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 521674001182 carboxyltransferase (CT) interaction site; other site 521674001183 biotinylation site [posttranslational modification]; other site 521674001184 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 521674001185 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674001186 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 521674001187 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521674001188 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 521674001189 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521674001190 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521674001191 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 521674001192 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521674001193 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521674001194 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521674001195 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521674001196 DNA binding site [nucleotide binding] 521674001197 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521674001198 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521674001199 S17 interaction site [polypeptide binding]; other site 521674001200 S8 interaction site; other site 521674001201 16S rRNA interaction site [nucleotide binding]; other site 521674001202 streptomycin interaction site [chemical binding]; other site 521674001203 23S rRNA interaction site [nucleotide binding]; other site 521674001204 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521674001205 30S ribosomal protein S7; Validated; Region: PRK05302 521674001206 elongation factor G; Reviewed; Region: PRK00007 521674001207 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521674001208 G1 box; other site 521674001209 putative GEF interaction site [polypeptide binding]; other site 521674001210 GTP/Mg2+ binding site [chemical binding]; other site 521674001211 Switch I region; other site 521674001212 G2 box; other site 521674001213 G3 box; other site 521674001214 Switch II region; other site 521674001215 G4 box; other site 521674001216 G5 box; other site 521674001217 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521674001218 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 521674001219 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521674001220 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 521674001221 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 521674001222 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 521674001223 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 521674001224 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521674001225 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521674001226 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521674001227 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 521674001228 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521674001229 putative translocon binding site; other site 521674001230 protein-rRNA interface [nucleotide binding]; other site 521674001231 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521674001232 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521674001233 G-X-X-G motif; other site 521674001234 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521674001235 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521674001236 23S rRNA interface [nucleotide binding]; other site 521674001237 5S rRNA interface [nucleotide binding]; other site 521674001238 putative antibiotic binding site [chemical binding]; other site 521674001239 L25 interface [polypeptide binding]; other site 521674001240 L27 interface [polypeptide binding]; other site 521674001241 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521674001242 putative translocon interaction site; other site 521674001243 23S rRNA interface [nucleotide binding]; other site 521674001244 signal recognition particle (SRP54) interaction site; other site 521674001245 L23 interface [polypeptide binding]; other site 521674001246 trigger factor interaction site; other site 521674001247 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 521674001248 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 521674001249 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521674001250 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 521674001251 RNA binding site [nucleotide binding]; other site 521674001252 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521674001253 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521674001254 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521674001255 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 521674001256 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 521674001257 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521674001258 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521674001259 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521674001260 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521674001261 23S rRNA interface [nucleotide binding]; other site 521674001262 L21e interface [polypeptide binding]; other site 521674001263 5S rRNA interface [nucleotide binding]; other site 521674001264 L27 interface [polypeptide binding]; other site 521674001265 L5 interface [polypeptide binding]; other site 521674001266 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 521674001267 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521674001268 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521674001269 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 521674001270 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521674001271 SecY translocase; Region: SecY; pfam00344 521674001272 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521674001273 30S ribosomal protein S13; Region: bact_S13; TIGR03631 521674001274 30S ribosomal protein S11; Validated; Region: PRK05309 521674001275 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521674001276 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521674001277 alphaNTD homodimer interface [polypeptide binding]; other site 521674001278 alphaNTD - beta interaction site [polypeptide binding]; other site 521674001279 alphaNTD - beta' interaction site [polypeptide binding]; other site 521674001280 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521674001281 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 521674001282 HEAT repeats; Region: HEAT_2; pfam13646 521674001283 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 521674001284 TROVE domain; Region: TROVE; pfam05731 521674001285 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674001286 metal ion-dependent adhesion site (MIDAS); other site 521674001287 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 521674001288 four helix bundle protein; Region: TIGR02436 521674001289 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 521674001290 RNA ligase; Region: RNA_ligase; pfam09414 521674001291 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 521674001292 Active_site [active] 521674001293 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 521674001294 four helix bundle protein; Region: TIGR02436 521674001295 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521674001296 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 521674001297 proposed catalytic triad [active] 521674001298 active site nucleophile [active] 521674001299 PAS fold; Region: PAS_4; pfam08448 521674001300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674001301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521674001302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674001303 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674001304 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674001305 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674001306 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674001307 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674001308 Sulfatase; Region: Sulfatase; cl17466 521674001309 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674001310 metal ion-dependent adhesion site (MIDAS); other site 521674001311 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674001312 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674001313 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674001314 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 521674001315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674001316 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674001317 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674001318 AAA domain; Region: AAA_26; pfam13500 521674001319 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 521674001320 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 521674001321 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 521674001322 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 521674001323 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674001324 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 521674001325 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 521674001326 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 521674001327 recombination factor protein RarA; Reviewed; Region: PRK13342 521674001328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001329 Walker A motif; other site 521674001330 ATP binding site [chemical binding]; other site 521674001331 Walker B motif; other site 521674001332 arginine finger; other site 521674001333 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 521674001334 AhpC/TSA family; Region: AhpC-TSA; pfam00578 521674001335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674001336 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674001337 active site 521674001338 ATP binding site [chemical binding]; other site 521674001339 substrate binding site [chemical binding]; other site 521674001340 activation loop (A-loop); other site 521674001341 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674001342 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 521674001343 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674001344 active site 521674001345 metal binding site [ion binding]; metal-binding site 521674001346 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 521674001347 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521674001348 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521674001349 active site 521674001350 catalytic tetrad [active] 521674001351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 521674001352 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 521674001353 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674001354 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 521674001355 GTPase RsgA; Reviewed; Region: PRK00098 521674001356 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521674001357 RNA binding site [nucleotide binding]; other site 521674001358 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521674001359 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521674001360 GTP/Mg2+ binding site [chemical binding]; other site 521674001361 G4 box; other site 521674001362 G5 box; other site 521674001363 G1 box; other site 521674001364 Switch I region; other site 521674001365 G2 box; other site 521674001366 G3 box; other site 521674001367 Switch II region; other site 521674001368 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674001369 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521674001370 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 521674001371 substrate binding site [chemical binding]; other site 521674001372 ATP binding site [chemical binding]; other site 521674001373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521674001374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521674001375 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674001376 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674001377 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674001378 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521674001379 CoA binding domain; Region: CoA_binding_2; pfam13380 521674001380 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 521674001381 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521674001382 substrate binding site [chemical binding]; other site 521674001383 ATP binding site [chemical binding]; other site 521674001384 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521674001385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674001386 Zn2+ binding site [ion binding]; other site 521674001387 Mg2+ binding site [ion binding]; other site 521674001388 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674001389 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674001390 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 521674001391 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 521674001392 putative NAD(P) binding site [chemical binding]; other site 521674001393 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 521674001394 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 521674001395 active site 521674001396 FMN binding site [chemical binding]; other site 521674001397 substrate binding site [chemical binding]; other site 521674001398 homotetramer interface [polypeptide binding]; other site 521674001399 catalytic residue [active] 521674001400 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674001401 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 521674001402 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674001403 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674001404 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674001405 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 521674001406 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674001407 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674001408 Sulfatase; Region: Sulfatase; pfam00884 521674001409 Uncharacterized conserved protein [Function unknown]; Region: COG1315 521674001410 Uncharacterized conserved protein [Function unknown]; Region: COG1315 521674001411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674001412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674001413 active site 521674001414 ATP binding site [chemical binding]; other site 521674001415 substrate binding site [chemical binding]; other site 521674001416 activation loop (A-loop); other site 521674001417 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674001418 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674001419 structural tetrad; other site 521674001420 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674001421 structural tetrad; other site 521674001422 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674001423 WD domain, G-beta repeat; Region: WD40; pfam00400 521674001424 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674001425 structural tetrad; other site 521674001426 Protein of unknown function (DUF493); Region: DUF493; pfam04359 521674001427 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 521674001428 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521674001429 putative NAD(P) binding site [chemical binding]; other site 521674001430 catalytic Zn binding site [ion binding]; other site 521674001431 structural Zn binding site [ion binding]; other site 521674001432 HEAT repeats; Region: HEAT_2; pfam13646 521674001433 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 521674001434 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674001435 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 521674001436 DinB superfamily; Region: DinB_2; pfam12867 521674001437 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521674001438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674001439 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674001440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521674001441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521674001442 metal binding site [ion binding]; metal-binding site 521674001443 active site 521674001444 I-site; other site 521674001445 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521674001446 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 521674001447 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 521674001448 active site 521674001449 Zn binding site [ion binding]; other site 521674001450 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674001451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674001452 catalytic residues [active] 521674001453 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521674001454 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 521674001455 motif 1; other site 521674001456 dimer interface [polypeptide binding]; other site 521674001457 active site 521674001458 motif 2; other site 521674001459 motif 3; other site 521674001460 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674001461 PQQ-like domain; Region: PQQ_2; pfam13360 521674001462 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674001463 active site 521674001464 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521674001465 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 521674001466 putative active site [active] 521674001467 metal binding site [ion binding]; metal-binding site 521674001468 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 521674001469 Stage II sporulation protein; Region: SpoIID; pfam08486 521674001470 TPR repeat; Region: TPR_11; pfam13414 521674001471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001472 binding surface 521674001473 TPR motif; other site 521674001474 TPR repeat; Region: TPR_11; pfam13414 521674001475 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521674001476 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521674001477 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521674001478 Clp amino terminal domain; Region: Clp_N; pfam02861 521674001479 Clp amino terminal domain; Region: Clp_N; pfam02861 521674001480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001481 Walker A motif; other site 521674001482 ATP binding site [chemical binding]; other site 521674001483 Walker B motif; other site 521674001484 arginine finger; other site 521674001485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001486 Walker A motif; other site 521674001487 ATP binding site [chemical binding]; other site 521674001488 Walker B motif; other site 521674001489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521674001490 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 521674001491 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 521674001492 thiamine phosphate binding site [chemical binding]; other site 521674001493 active site 521674001494 pyrophosphate binding site [ion binding]; other site 521674001495 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 521674001496 SnoaL-like domain; Region: SnoaL_3; pfam13474 521674001497 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521674001498 EamA-like transporter family; Region: EamA; pfam00892 521674001499 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521674001500 GcpE protein; Region: GcpE; pfam04551 521674001501 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521674001502 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 521674001503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521674001504 homodimer interface [polypeptide binding]; other site 521674001505 substrate-cofactor binding pocket; other site 521674001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674001507 catalytic residue [active] 521674001508 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521674001509 trimer interface [polypeptide binding]; other site 521674001510 active site 521674001511 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521674001512 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521674001513 minor groove reading motif; other site 521674001514 helix-hairpin-helix signature motif; other site 521674001515 substrate binding pocket [chemical binding]; other site 521674001516 active site 521674001517 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 521674001518 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674001519 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674001520 metal ion-dependent adhesion site (MIDAS); other site 521674001521 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674001522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001523 Walker A motif; other site 521674001524 ATP binding site [chemical binding]; other site 521674001525 Walker B motif; other site 521674001526 arginine finger; other site 521674001527 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 521674001528 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674001529 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 521674001530 Leucine rich repeat; Region: LRR_8; pfam13855 521674001531 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 521674001532 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521674001533 E3 interaction surface; other site 521674001534 lipoyl attachment site [posttranslational modification]; other site 521674001535 e3 binding domain; Region: E3_binding; pfam02817 521674001536 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521674001537 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 521674001538 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 521674001539 TPP-binding site [chemical binding]; other site 521674001540 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 521674001541 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 521674001542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 521674001543 PilZ domain; Region: PilZ; pfam07238 521674001544 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521674001545 nucleotide binding site [chemical binding]; other site 521674001546 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674001547 SBD interface [polypeptide binding]; other site 521674001548 DNA-K related protein; Region: DUF3731; pfam12531 521674001549 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674001550 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674001551 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521674001552 MarR family; Region: MarR_2; cl17246 521674001553 Pirin-related protein [General function prediction only]; Region: COG1741 521674001554 Pirin; Region: Pirin; pfam02678 521674001555 Predicted membrane protein [Function unknown]; Region: COG2259 521674001556 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674001557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521674001558 active site 521674001559 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 521674001560 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674001561 Bacterial sugar transferase; Region: Bac_transf; pfam02397 521674001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674001563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674001564 active site 521674001565 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 521674001566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674001567 putative ADP-binding pocket [chemical binding]; other site 521674001568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674001569 S-adenosylmethionine binding site [chemical binding]; other site 521674001570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674001571 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 521674001572 putative ADP-binding pocket [chemical binding]; other site 521674001573 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521674001574 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521674001575 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521674001576 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521674001577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674001578 catalytic residue [active] 521674001579 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674001580 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674001581 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 521674001582 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 521674001583 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 521674001584 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 521674001585 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521674001586 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 521674001587 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 521674001588 substrate binding site [chemical binding]; other site 521674001589 hexamer interface [polypeptide binding]; other site 521674001590 metal binding site [ion binding]; metal-binding site 521674001591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521674001592 catalytic core [active] 521674001593 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 521674001594 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 521674001595 Sulfatase; Region: Sulfatase; cl17466 521674001596 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674001597 IncA protein; Region: IncA; pfam04156 521674001598 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 521674001599 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 521674001600 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 521674001601 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 521674001602 TPR repeat; Region: TPR_11; pfam13414 521674001603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001604 TPR motif; other site 521674001605 binding surface 521674001606 TPR repeat; Region: TPR_11; pfam13414 521674001607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001608 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674001609 binding surface 521674001610 TPR motif; other site 521674001611 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674001612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674001613 S-adenosylmethionine binding site [chemical binding]; other site 521674001614 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674001615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674001616 S-adenosylmethionine binding site [chemical binding]; other site 521674001617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674001618 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521674001619 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 521674001620 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521674001621 Ligand binding site; other site 521674001622 Putative Catalytic site; other site 521674001623 DXD motif; other site 521674001624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521674001625 Sel1-like repeats; Region: SEL1; smart00671 521674001626 Sel1-like repeats; Region: SEL1; smart00671 521674001627 Sel1-like repeats; Region: SEL1; smart00671 521674001628 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521674001629 Sel1-like repeats; Region: SEL1; smart00671 521674001630 Sel1-like repeats; Region: SEL1; smart00671 521674001631 Sel1-like repeats; Region: SEL1; smart00671 521674001632 Sel1-like repeats; Region: SEL1; smart00671 521674001633 TPR repeat; Region: TPR_11; pfam13414 521674001634 C-terminal peptidase (prc); Region: prc; TIGR00225 521674001635 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521674001636 protein binding site [polypeptide binding]; other site 521674001637 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521674001638 Catalytic dyad [active] 521674001639 chaperone protein DnaJ; Provisional; Region: PRK14299 521674001640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674001641 HSP70 interaction site [polypeptide binding]; other site 521674001642 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521674001643 substrate binding site [polypeptide binding]; other site 521674001644 dimer interface [polypeptide binding]; other site 521674001645 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 521674001646 active site 521674001647 catalytic triad [active] 521674001648 oxyanion hole [active] 521674001649 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674001650 HEAT repeats; Region: HEAT_2; pfam13646 521674001651 HEAT repeats; Region: HEAT_2; pfam13646 521674001652 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674001653 Cytochrome c; Region: Cytochrom_C; pfam00034 521674001654 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 521674001655 Protein export membrane protein; Region: SecD_SecF; cl14618 521674001656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674001657 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 521674001658 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674001659 ribonuclease D; Region: rnd; TIGR01388 521674001660 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 521674001661 catalytic site [active] 521674001662 putative active site [active] 521674001663 putative substrate binding site [chemical binding]; other site 521674001664 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 521674001665 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521674001666 DHH family; Region: DHH; pfam01368 521674001667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001668 TPR motif; other site 521674001669 binding surface 521674001670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674001671 binding surface 521674001672 TPR motif; other site 521674001673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674001674 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674001675 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 521674001676 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521674001677 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 521674001678 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 521674001679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 521674001680 PAS domain S-box; Region: sensory_box; TIGR00229 521674001681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674001682 putative active site [active] 521674001683 heme pocket [chemical binding]; other site 521674001684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674001685 dimer interface [polypeptide binding]; other site 521674001686 phosphorylation site [posttranslational modification] 521674001687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674001688 ATP binding site [chemical binding]; other site 521674001689 Mg2+ binding site [ion binding]; other site 521674001690 G-X-G motif; other site 521674001691 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674001692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001693 active site 521674001694 phosphorylation site [posttranslational modification] 521674001695 intermolecular recognition site; other site 521674001696 dimerization interface [polypeptide binding]; other site 521674001697 Response regulator receiver domain; Region: Response_reg; pfam00072 521674001698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001699 active site 521674001700 phosphorylation site [posttranslational modification] 521674001701 intermolecular recognition site; other site 521674001702 dimerization interface [polypeptide binding]; other site 521674001703 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 521674001704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001705 active site 521674001706 phosphorylation site [posttranslational modification] 521674001707 intermolecular recognition site; other site 521674001708 dimerization interface [polypeptide binding]; other site 521674001709 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674001710 Zn2+ binding site [ion binding]; other site 521674001711 Mg2+ binding site [ion binding]; other site 521674001712 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521674001713 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 521674001714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674001715 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521674001716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521674001717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674001718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674001719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674001720 Walker A/P-loop; other site 521674001721 ATP binding site [chemical binding]; other site 521674001722 Q-loop/lid; other site 521674001723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674001724 ABC transporter signature motif; other site 521674001725 Walker B; other site 521674001726 D-loop; other site 521674001727 H-loop/switch region; other site 521674001728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674001729 Walker A/P-loop; other site 521674001730 ATP binding site [chemical binding]; other site 521674001731 Q-loop/lid; other site 521674001732 ABC transporter signature motif; other site 521674001733 Walker B; other site 521674001734 D-loop; other site 521674001735 H-loop/switch region; other site 521674001736 glutamine synthetase, type I; Region: GlnA; TIGR00653 521674001737 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521674001738 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521674001739 HEAT repeats; Region: HEAT_2; pfam13646 521674001740 Domain of unknown function DUF11; Region: DUF11; cl17728 521674001741 Domain of unknown function DUF11; Region: DUF11; pfam01345 521674001742 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674001743 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 521674001744 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 521674001745 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 521674001746 active site 521674001747 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 521674001748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674001749 FeS/SAM binding site; other site 521674001750 HemN C-terminal domain; Region: HemN_C; pfam06969 521674001751 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 521674001752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001753 Walker A motif; other site 521674001754 ATP binding site [chemical binding]; other site 521674001755 Walker B motif; other site 521674001756 arginine finger; other site 521674001757 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 521674001758 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 521674001759 recombination protein RecR; Reviewed; Region: recR; PRK00076 521674001760 RecR protein; Region: RecR; pfam02132 521674001761 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 521674001762 putative active site [active] 521674001763 putative metal-binding site [ion binding]; other site 521674001764 tetramer interface [polypeptide binding]; other site 521674001765 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 521674001766 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 521674001767 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 521674001768 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 521674001769 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674001770 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521674001771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674001772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674001773 DNA binding residues [nucleotide binding] 521674001774 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674001775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001776 active site 521674001777 phosphorylation site [posttranslational modification] 521674001778 intermolecular recognition site; other site 521674001779 dimerization interface [polypeptide binding]; other site 521674001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001781 Walker A motif; other site 521674001782 ATP binding site [chemical binding]; other site 521674001783 Walker B motif; other site 521674001784 arginine finger; other site 521674001785 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 521674001786 active site 521674001787 catalytic residues [active] 521674001788 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 521674001789 active site 521674001790 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 521674001791 RNA/DNA hybrid binding site [nucleotide binding]; other site 521674001792 active site 521674001793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674001794 Sulfatase; Region: Sulfatase; cl17466 521674001795 Sulfatase; Region: Sulfatase; cl17466 521674001796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521674001797 MarR family; Region: MarR_2; pfam12802 521674001798 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521674001799 Putative esterase; Region: Esterase; pfam00756 521674001800 hypothetical protein; Provisional; Region: PRK11239 521674001801 Protein of unknown function, DUF480; Region: DUF480; cl01209 521674001802 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 521674001803 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 521674001804 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 521674001805 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 521674001806 active site 521674001807 Riboflavin kinase; Region: Flavokinase; pfam01687 521674001808 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 521674001809 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 521674001810 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 521674001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674001812 active site 521674001813 phosphorylation site [posttranslational modification] 521674001814 intermolecular recognition site; other site 521674001815 dimerization interface [polypeptide binding]; other site 521674001816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674001817 Walker A motif; other site 521674001818 ATP binding site [chemical binding]; other site 521674001819 Walker B motif; other site 521674001820 arginine finger; other site 521674001821 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 521674001822 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 521674001823 putative binding surface; other site 521674001824 active site 521674001825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521674001826 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521674001827 putative acyl-acceptor binding pocket; other site 521674001828 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 521674001829 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521674001830 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 521674001831 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 521674001832 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 521674001833 N- and C-terminal domain interface [polypeptide binding]; other site 521674001834 D-xylulose kinase; Region: XylB; TIGR01312 521674001835 active site 521674001836 MgATP binding site [chemical binding]; other site 521674001837 catalytic site [active] 521674001838 metal binding site [ion binding]; metal-binding site 521674001839 xylulose binding site [chemical binding]; other site 521674001840 homodimer interface [polypeptide binding]; other site 521674001841 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 521674001842 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 521674001843 Recombination protein O N terminal; Region: RecO_N; pfam11967 521674001844 Recombination protein O C terminal; Region: RecO_C; pfam02565 521674001845 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 521674001846 Lipopolysaccharide-assembly; Region: LptE; pfam04390 521674001847 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 521674001848 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 521674001849 NADP binding site [chemical binding]; other site 521674001850 dimer interface [polypeptide binding]; other site 521674001851 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 521674001852 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 521674001853 dimer interface [polypeptide binding]; other site 521674001854 active site residues [active] 521674001855 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 521674001856 SET domain; Region: SET; pfam00856 521674001857 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 521674001858 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521674001859 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521674001860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521674001861 RNA binding surface [nucleotide binding]; other site 521674001862 adenylate kinase; Region: adk; TIGR01351 521674001863 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521674001864 AMP-binding site [chemical binding]; other site 521674001865 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521674001866 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521674001867 putative active site [active] 521674001868 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521674001869 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 521674001870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674001871 FeS/SAM binding site; other site 521674001872 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 521674001873 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 521674001874 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 521674001875 dimer interface [polypeptide binding]; other site 521674001876 putative tRNA-binding site [nucleotide binding]; other site 521674001877 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 521674001878 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 521674001879 dimerization interface [polypeptide binding]; other site 521674001880 putative ATP binding site [chemical binding]; other site 521674001881 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 521674001882 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521674001883 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674001884 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521674001885 Walker A/P-loop; other site 521674001886 ATP binding site [chemical binding]; other site 521674001887 Q-loop/lid; other site 521674001888 ABC transporter signature motif; other site 521674001889 Walker B; other site 521674001890 D-loop; other site 521674001891 H-loop/switch region; other site 521674001892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521674001893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674001894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674001895 Walker A/P-loop; other site 521674001896 ATP binding site [chemical binding]; other site 521674001897 Q-loop/lid; other site 521674001898 ABC transporter signature motif; other site 521674001899 Walker B; other site 521674001900 D-loop; other site 521674001901 H-loop/switch region; other site 521674001902 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674001903 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 521674001904 Haem-binding domain; Region: Haem_bd; pfam14376 521674001905 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 521674001906 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 521674001907 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674001908 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521674001909 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521674001910 metal binding site 2 [ion binding]; metal-binding site 521674001911 putative DNA binding helix; other site 521674001912 metal binding site 1 [ion binding]; metal-binding site 521674001913 dimer interface [polypeptide binding]; other site 521674001914 structural Zn2+ binding site [ion binding]; other site 521674001915 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 521674001916 homodecamer interface [polypeptide binding]; other site 521674001917 GTP cyclohydrolase I; Provisional; Region: PLN03044 521674001918 active site 521674001919 putative catalytic site residues [active] 521674001920 zinc binding site [ion binding]; other site 521674001921 GTP-CH-I/GFRP interaction surface; other site 521674001922 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674001923 anti sigma factor interaction site; other site 521674001924 regulatory phosphorylation site [posttranslational modification]; other site 521674001925 Type II/IV secretion system protein; Region: T2SE; pfam00437 521674001926 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674001927 Walker A motif; other site 521674001928 ATP binding site [chemical binding]; other site 521674001929 Walker B motif; other site 521674001930 putative cation:proton antiport protein; Provisional; Region: PRK10669 521674001931 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521674001932 TrkA-N domain; Region: TrkA_N; pfam02254 521674001933 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 521674001934 putative cation:proton antiport protein; Provisional; Region: PRK10669 521674001935 TrkA-N domain; Region: TrkA_N; pfam02254 521674001936 TrkA-C domain; Region: TrkA_C; pfam02080 521674001937 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521674001938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521674001939 nucleotide binding site [chemical binding]; other site 521674001940 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674001941 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674001942 structural tetrad; other site 521674001943 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 521674001944 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 521674001945 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 521674001946 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 521674001947 UvrB/uvrC motif; Region: UVR; pfam02151 521674001948 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 521674001949 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 521674001950 ADP binding site [chemical binding]; other site 521674001951 phosphagen binding site; other site 521674001952 substrate specificity loop; other site 521674001953 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 521674001954 substrate binding site; other site 521674001955 dimer interface; other site 521674001956 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 521674001957 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 521674001958 FTR, proximal lobe; Region: FTR_C; pfam02741 521674001959 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521674001960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674001961 Walker A/P-loop; other site 521674001962 ATP binding site [chemical binding]; other site 521674001963 Q-loop/lid; other site 521674001964 ABC transporter signature motif; other site 521674001965 Walker B; other site 521674001966 D-loop; other site 521674001967 H-loop/switch region; other site 521674001968 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 521674001969 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 521674001970 CAAX protease self-immunity; Region: Abi; pfam02517 521674001971 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521674001972 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521674001973 active site 521674001974 HIGH motif; other site 521674001975 dimer interface [polypeptide binding]; other site 521674001976 KMSKS motif; other site 521674001977 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 521674001978 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 521674001979 heterodimer interface [polypeptide binding]; other site 521674001980 active site 521674001981 FMN binding site [chemical binding]; other site 521674001982 homodimer interface [polypeptide binding]; other site 521674001983 substrate binding site [chemical binding]; other site 521674001984 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 521674001985 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 521674001986 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 521674001987 putative dimerization interface [polypeptide binding]; other site 521674001988 putative ligand binding site [chemical binding]; other site 521674001989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521674001990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674001991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521674001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674001993 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674001994 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674001995 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674001996 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674001997 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 521674001998 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 521674001999 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 521674002000 ligand binding site [chemical binding]; other site 521674002001 dimerization interface [polypeptide binding]; other site 521674002002 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521674002003 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521674002004 Walker A/P-loop; other site 521674002005 ATP binding site [chemical binding]; other site 521674002006 Q-loop/lid; other site 521674002007 ABC transporter signature motif; other site 521674002008 Walker B; other site 521674002009 D-loop; other site 521674002010 H-loop/switch region; other site 521674002011 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521674002012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521674002013 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521674002014 TM-ABC transporter signature motif; other site 521674002015 MutL protein; Region: MutL; pfam13941 521674002016 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 521674002017 active site 521674002018 Zn binding site [ion binding]; other site 521674002019 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674002020 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674002021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521674002022 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521674002023 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674002024 Sulfatase; Region: Sulfatase; cl17466 521674002025 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 521674002026 active site 521674002027 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 521674002028 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674002029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674002030 active site 521674002031 phosphorylation site [posttranslational modification] 521674002032 intermolecular recognition site; other site 521674002033 dimerization interface [polypeptide binding]; other site 521674002034 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521674002035 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 521674002036 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 521674002037 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 521674002038 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674002039 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 521674002040 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521674002041 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 521674002042 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 521674002043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521674002044 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521674002045 active site 521674002046 catalytic tetrad [active] 521674002047 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 521674002048 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674002049 metal ion-dependent adhesion site (MIDAS); other site 521674002050 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 521674002051 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 521674002052 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 521674002053 dimer interface [polypeptide binding]; other site 521674002054 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521674002055 catalytic triad [active] 521674002056 peroxidatic and resolving cysteines [active] 521674002057 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674002058 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 521674002059 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 521674002060 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 521674002061 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674002062 GAF domain; Region: GAF; pfam01590 521674002063 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674002064 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674002065 Peptidase C26; Region: Peptidase_C26; pfam07722 521674002066 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 521674002067 catalytic triad [active] 521674002068 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 521674002069 RF-1 domain; Region: RF-1; pfam00472 521674002070 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674002071 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674002072 DinB superfamily; Region: DinB_2; pfam12867 521674002073 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521674002074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674002075 active site 521674002076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674002077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674002078 active site 521674002079 ATP binding site [chemical binding]; other site 521674002080 substrate binding site [chemical binding]; other site 521674002081 activation loop (A-loop); other site 521674002082 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674002083 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674002084 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674002085 metal ion-dependent adhesion site (MIDAS); other site 521674002086 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 521674002087 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 521674002088 Flagellin N-methylase; Region: FliB; pfam03692 521674002089 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 521674002090 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 521674002091 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674002092 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 521674002093 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521674002094 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 521674002095 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 521674002096 inhibitor-cofactor binding pocket; inhibition site 521674002097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674002098 catalytic residue [active] 521674002099 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 521674002100 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 521674002101 dimer interface [polypeptide binding]; other site 521674002102 putative anticodon binding site; other site 521674002103 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 521674002104 motif 1; other site 521674002105 active site 521674002106 motif 2; other site 521674002107 motif 3; other site 521674002108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674002109 metal ion-dependent adhesion site (MIDAS); other site 521674002110 CARDB; Region: CARDB; pfam07705 521674002111 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674002112 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 521674002113 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521674002114 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521674002115 dimerization interface 3.5A [polypeptide binding]; other site 521674002116 active site 521674002117 seryl-tRNA synthetase; Provisional; Region: PRK05431 521674002118 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521674002119 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 521674002120 dimer interface [polypeptide binding]; other site 521674002121 active site 521674002122 motif 1; other site 521674002123 motif 2; other site 521674002124 motif 3; other site 521674002125 hypothetical protein; Provisional; Region: PRK08201 521674002126 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 521674002127 metal binding site [ion binding]; metal-binding site 521674002128 putative dimer interface [polypeptide binding]; other site 521674002129 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002130 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 521674002131 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 521674002132 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 521674002133 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521674002134 Part of AAA domain; Region: AAA_19; pfam13245 521674002135 Family description; Region: UvrD_C_2; pfam13538 521674002136 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 521674002137 fumarate hydratase; Reviewed; Region: fumC; PRK00485 521674002138 Class II fumarases; Region: Fumarase_classII; cd01362 521674002139 active site 521674002140 tetramer interface [polypeptide binding]; other site 521674002141 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 521674002142 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 521674002143 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 521674002144 hypothetical protein; Provisional; Region: PRK13665 521674002145 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 521674002146 Peptidase family M28; Region: Peptidase_M28; pfam04389 521674002147 metal binding site [ion binding]; metal-binding site 521674002148 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 521674002149 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674002150 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 521674002151 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 521674002152 MoaE homodimer interface [polypeptide binding]; other site 521674002153 MoaD interaction [polypeptide binding]; other site 521674002154 active site residues [active] 521674002155 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 521674002156 MoaE interaction surface [polypeptide binding]; other site 521674002157 MoeB interaction surface [polypeptide binding]; other site 521674002158 thiocarboxylated glycine; other site 521674002159 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 521674002160 FAD binding domain; Region: FAD_binding_4; pfam01565 521674002161 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521674002162 Cysteine-rich domain; Region: CCG; pfam02754 521674002163 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674002164 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674002165 active site 521674002166 metal binding site [ion binding]; metal-binding site 521674002167 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674002168 metal ion-dependent adhesion site (MIDAS); other site 521674002169 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 521674002170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674002171 PGAP1-like protein; Region: PGAP1; pfam07819 521674002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 521674002173 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521674002174 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 521674002175 catalytic center binding site [active] 521674002176 ATP binding site [chemical binding]; other site 521674002177 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 521674002178 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002179 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 521674002180 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674002181 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674002182 phosphopeptide binding site; other site 521674002183 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521674002184 classical (c) SDRs; Region: SDR_c; cd05233 521674002185 NAD(P) binding site [chemical binding]; other site 521674002186 active site 521674002187 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 521674002188 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 521674002189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674002190 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521674002191 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521674002192 Transposase IS200 like; Region: Y1_Tnp; pfam01797 521674002193 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 521674002194 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 521674002195 dimer interface [polypeptide binding]; other site 521674002196 PYR/PP interface [polypeptide binding]; other site 521674002197 TPP binding site [chemical binding]; other site 521674002198 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 521674002199 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 521674002200 TPP-binding site [chemical binding]; other site 521674002201 dimer interface [polypeptide binding]; other site 521674002202 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 521674002203 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 521674002204 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 521674002205 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521674002206 Ligand binding site; other site 521674002207 DXD motif; other site 521674002208 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 521674002209 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 521674002210 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521674002211 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 521674002212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674002213 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521674002214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674002215 DNA binding residues [nucleotide binding] 521674002216 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 521674002217 dimer interface [polypeptide binding]; other site 521674002218 Citrate synthase; Region: Citrate_synt; pfam00285 521674002219 active site 521674002220 citrylCoA binding site [chemical binding]; other site 521674002221 oxalacetate/citrate binding site [chemical binding]; other site 521674002222 coenzyme A binding site [chemical binding]; other site 521674002223 catalytic triad [active] 521674002224 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 521674002225 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 521674002226 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 521674002227 putative ribose interaction site [chemical binding]; other site 521674002228 putative ADP binding site [chemical binding]; other site 521674002229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674002230 active site 521674002231 nucleotide binding site [chemical binding]; other site 521674002232 HIGH motif; other site 521674002233 KMSKS motif; other site 521674002234 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 521674002235 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 521674002236 putative active site [active] 521674002237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674002238 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521674002239 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 521674002240 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 521674002241 active site 521674002242 catalytic triad [active] 521674002243 oxyanion hole [active] 521674002244 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674002245 HEAT repeats; Region: HEAT_2; pfam13646 521674002246 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674002247 Cytochrome c; Region: Cytochrom_C; pfam00034 521674002248 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 521674002249 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 521674002250 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 521674002251 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521674002252 ApbE family; Region: ApbE; pfam02424 521674002253 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674002254 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674002255 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 521674002256 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 521674002257 generic binding surface II; other site 521674002258 ssDNA binding site; other site 521674002259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002260 ATP binding site [chemical binding]; other site 521674002261 putative Mg++ binding site [ion binding]; other site 521674002262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002263 nucleotide binding region [chemical binding]; other site 521674002264 ATP-binding site [chemical binding]; other site 521674002265 ACT domain-containing protein [General function prediction only]; Region: COG4747 521674002266 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674002267 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674002268 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 521674002269 Fasciclin domain; Region: Fasciclin; pfam02469 521674002270 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674002271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674002272 DNA binding residues [nucleotide binding] 521674002273 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 521674002274 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674002275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674002276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674002277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674002278 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 521674002279 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 521674002280 active site 521674002281 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 521674002282 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 521674002283 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 521674002284 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 521674002285 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521674002286 PCRF domain; Region: PCRF; pfam03462 521674002287 RF-1 domain; Region: RF-1; pfam00472 521674002288 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 521674002289 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 521674002290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674002291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521674002292 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 521674002293 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521674002294 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 521674002295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521674002296 catalytic core [active] 521674002297 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674002298 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674002299 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 521674002300 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674002301 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674002302 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674002303 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 521674002304 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674002305 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674002306 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 521674002307 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521674002308 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521674002309 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521674002310 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521674002311 NAD(P) binding site [chemical binding]; other site 521674002312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674002313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674002314 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521674002315 Walker A/P-loop; other site 521674002316 ATP binding site [chemical binding]; other site 521674002317 Q-loop/lid; other site 521674002318 ABC transporter signature motif; other site 521674002319 Walker B; other site 521674002320 D-loop; other site 521674002321 H-loop/switch region; other site 521674002322 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674002323 Sulfatase; Region: Sulfatase; pfam00884 521674002324 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 521674002325 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 521674002326 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674002327 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002328 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674002329 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002330 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 521674002331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 521674002332 DNA binding site [nucleotide binding] 521674002333 active site 521674002334 GH3 auxin-responsive promoter; Region: GH3; pfam03321 521674002335 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 521674002336 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521674002337 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521674002338 Na binding site [ion binding]; other site 521674002339 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002340 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002341 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 521674002342 putative hydrophobic ligand binding site [chemical binding]; other site 521674002343 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 521674002344 TIGR01777 family protein; Region: yfcH 521674002345 putative NAD(P) binding site [chemical binding]; other site 521674002346 putative active site [active] 521674002347 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 521674002348 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 521674002349 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 521674002350 excinuclease ABC subunit B; Provisional; Region: PRK05298 521674002351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002352 ATP binding site [chemical binding]; other site 521674002353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002354 nucleotide binding region [chemical binding]; other site 521674002355 ATP-binding site [chemical binding]; other site 521674002356 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521674002357 UvrB/uvrC motif; Region: UVR; pfam02151 521674002358 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674002359 Trp docking motif [polypeptide binding]; other site 521674002360 PQQ-like domain; Region: PQQ_2; pfam13360 521674002361 active site 521674002362 PQQ-like domain; Region: PQQ_2; pfam13360 521674002363 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674002364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674002365 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674002366 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674002367 active site 521674002368 ATP binding site [chemical binding]; other site 521674002369 substrate binding site [chemical binding]; other site 521674002370 activation loop (A-loop); other site 521674002371 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674002372 structural tetrad; other site 521674002373 PQQ-like domain; Region: PQQ_2; pfam13360 521674002374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 521674002375 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 521674002376 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 521674002377 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674002378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674002379 binding surface 521674002380 TPR motif; other site 521674002381 TPR repeat; Region: TPR_11; pfam13414 521674002382 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 521674002383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674002384 Walker A/P-loop; other site 521674002385 ATP binding site [chemical binding]; other site 521674002386 Q-loop/lid; other site 521674002387 ABC transporter signature motif; other site 521674002388 Walker B; other site 521674002389 D-loop; other site 521674002390 H-loop/switch region; other site 521674002391 FtsX-like permease family; Region: FtsX; pfam02687 521674002392 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674002393 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674002394 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674002395 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 521674002396 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674002397 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674002398 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674002399 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 521674002400 catalytic nucleophile [active] 521674002401 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 521674002402 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 521674002403 Penicillinase repressor; Region: Pencillinase_R; pfam03965 521674002404 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002405 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002406 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002407 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521674002408 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 521674002409 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 521674002410 active site pocket [active] 521674002411 putative dimer interface [polypeptide binding]; other site 521674002412 putative cataytic base [active] 521674002413 cobalamin synthase; Reviewed; Region: cobS; PRK00235 521674002414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521674002415 catalytic core [active] 521674002416 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 521674002417 EVE domain; Region: EVE; cl00728 521674002418 AMOP domain; Region: AMOP; cl02758 521674002419 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 521674002420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674002421 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 521674002422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674002423 active site 521674002424 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521674002425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521674002426 active site 521674002427 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 521674002428 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 521674002429 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 521674002430 NADP binding site [chemical binding]; other site 521674002431 active site 521674002432 putative substrate binding site [chemical binding]; other site 521674002433 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 521674002434 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674002435 RHS Repeat; Region: RHS_repeat; pfam05593 521674002436 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674002437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521674002438 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674002439 RHS Repeat; Region: RHS_repeat; pfam05593 521674002440 RHS Repeat; Region: RHS_repeat; pfam05593 521674002441 RHS Repeat; Region: RHS_repeat; cl11982 521674002442 RHS Repeat; Region: RHS_repeat; cl11982 521674002443 RHS Repeat; Region: RHS_repeat; cl11982 521674002444 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674002445 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674002446 RHS Repeat; Region: RHS_repeat; cl11982 521674002447 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674002448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521674002449 active site 521674002450 Fringe-like; Region: Fringe; pfam02434 521674002451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 521674002452 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 521674002453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674002454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674002455 S-adenosylmethionine binding site [chemical binding]; other site 521674002456 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521674002457 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 521674002458 Probable Catalytic site; other site 521674002459 metal-binding site 521674002460 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521674002461 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 521674002462 putative metal binding site; other site 521674002463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674002464 TPR motif; other site 521674002465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674002466 binding surface 521674002467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674002468 binding surface 521674002469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674002470 TPR motif; other site 521674002471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674002472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521674002473 NTPase; Region: NTPase_1; cl17478 521674002474 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521674002475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674002476 Walker A motif; other site 521674002477 ATP binding site [chemical binding]; other site 521674002478 Walker B motif; other site 521674002479 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 521674002480 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 521674002481 TIR domain; Region: TIR_2; pfam13676 521674002482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002483 ATP binding site [chemical binding]; other site 521674002484 putative Mg++ binding site [ion binding]; other site 521674002485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002486 nucleotide binding region [chemical binding]; other site 521674002487 ATP-binding site [chemical binding]; other site 521674002488 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 521674002489 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 521674002490 5' RNA guide strand anchoring site; other site 521674002491 active site 521674002492 SIR2-like domain; Region: SIR2_2; pfam13289 521674002493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674002494 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521674002495 Walker A motif; other site 521674002496 ATP binding site [chemical binding]; other site 521674002497 Walker B motif; other site 521674002498 arginine finger; other site 521674002499 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 521674002500 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 521674002501 active site 521674002502 catalytic triad [active] 521674002503 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 521674002504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002505 ATP binding site [chemical binding]; other site 521674002506 putative Mg++ binding site [ion binding]; other site 521674002507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002508 nucleotide binding region [chemical binding]; other site 521674002509 ATP-binding site [chemical binding]; other site 521674002510 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 521674002511 AAA ATPase domain; Region: AAA_16; pfam13191 521674002512 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 521674002513 tellurite resistance protein terB; Region: terB; cd07176 521674002514 putative metal binding site [ion binding]; other site 521674002515 AAA domain; Region: AAA_11; pfam13086 521674002516 Part of AAA domain; Region: AAA_19; pfam13245 521674002517 AAA domain; Region: AAA_12; pfam13087 521674002518 AAA ATPase domain; Region: AAA_16; pfam13191 521674002519 Family description; Region: UvrD_C_2; pfam13538 521674002520 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 521674002521 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674002522 HSP70 interaction site [polypeptide binding]; other site 521674002523 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 521674002524 putative DNA binding surface [nucleotide binding]; other site 521674002525 dimer interface [polypeptide binding]; other site 521674002526 beta-clamp/clamp loader binding surface; other site 521674002527 beta-clamp/translesion DNA polymerase binding surface; other site 521674002528 Ycf46; Provisional; Region: ycf46; CHL00195 521674002529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674002530 Walker A motif; other site 521674002531 ATP binding site [chemical binding]; other site 521674002532 Walker B motif; other site 521674002533 arginine finger; other site 521674002534 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 521674002535 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521674002536 cheY-homologous receiver domain; Region: REC; smart00448 521674002537 active site 521674002538 phosphorylation site [posttranslational modification] 521674002539 intermolecular recognition site; other site 521674002540 Response regulator receiver domain; Region: Response_reg; pfam00072 521674002541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674002542 active site 521674002543 phosphorylation site [posttranslational modification] 521674002544 intermolecular recognition site; other site 521674002545 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 521674002546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521674002547 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 521674002548 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521674002549 active site 521674002550 catalytic residues [active] 521674002551 DNA binding site [nucleotide binding] 521674002552 Int/Topo IB signature motif; other site 521674002553 NusB family; Region: NusB; pfam01029 521674002554 16S rRNA methyltransferase B; Provisional; Region: PRK14901 521674002555 putative RNA binding site [nucleotide binding]; other site 521674002556 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 521674002557 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 521674002558 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 521674002559 hinge; other site 521674002560 active site 521674002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674002562 TIGR01777 family protein; Region: yfcH 521674002563 NAD(P) binding site [chemical binding]; other site 521674002564 active site 521674002565 ABC1 family; Region: ABC1; cl17513 521674002566 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 521674002567 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 521674002568 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 521674002569 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 521674002570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674002571 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674002572 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674002573 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674002574 Walker A/P-loop; other site 521674002575 ATP binding site [chemical binding]; other site 521674002576 Q-loop/lid; other site 521674002577 ABC transporter signature motif; other site 521674002578 Walker B; other site 521674002579 D-loop; other site 521674002580 H-loop/switch region; other site 521674002581 DevC protein; Region: devC; TIGR01185 521674002582 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674002583 FtsX-like permease family; Region: FtsX; pfam02687 521674002584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521674002585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521674002586 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 521674002587 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674002588 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674002589 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674002590 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674002591 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674002592 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 521674002593 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521674002594 Catalytic site [active] 521674002595 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 521674002596 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 521674002597 Walker A/P-loop; other site 521674002598 ATP binding site [chemical binding]; other site 521674002599 Q-loop/lid; other site 521674002600 ABC transporter signature motif; other site 521674002601 Walker B; other site 521674002602 D-loop; other site 521674002603 H-loop/switch region; other site 521674002604 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 521674002605 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 521674002606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674002607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674002608 DNA binding residues [nucleotide binding] 521674002609 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521674002610 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 521674002611 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521674002612 Mg++ binding site [ion binding]; other site 521674002613 putative catalytic motif [active] 521674002614 putative substrate binding site [chemical binding]; other site 521674002615 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 521674002616 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521674002617 active site 521674002618 HIGH motif; other site 521674002619 KMSKS motif; other site 521674002620 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521674002621 tRNA binding surface [nucleotide binding]; other site 521674002622 anticodon binding site; other site 521674002623 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 521674002624 dimer interface [polypeptide binding]; other site 521674002625 putative tRNA-binding site [nucleotide binding]; other site 521674002626 malate dehydrogenase; Provisional; Region: PRK05442 521674002627 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 521674002628 NAD(P) binding site [chemical binding]; other site 521674002629 dimer interface [polypeptide binding]; other site 521674002630 malate binding site [chemical binding]; other site 521674002631 glycogen synthase; Provisional; Region: glgA; PRK00654 521674002632 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 521674002633 ADP-binding pocket [chemical binding]; other site 521674002634 homodimer interface [polypeptide binding]; other site 521674002635 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 521674002636 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 521674002637 FHIPEP family; Region: FHIPEP; pfam00771 521674002638 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 521674002639 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 521674002640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674002641 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521674002642 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674002643 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674002644 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 521674002645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674002646 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521674002647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674002648 DNA binding residues [nucleotide binding] 521674002649 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521674002650 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 521674002651 inhibitor-cofactor binding pocket; inhibition site 521674002652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674002653 catalytic residue [active] 521674002654 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 521674002655 classical (c) SDRs; Region: SDR_c; cd05233 521674002656 NAD(P) binding site [chemical binding]; other site 521674002657 active site 521674002658 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 521674002659 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674002660 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674002661 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 521674002662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674002663 S-adenosylmethionine binding site [chemical binding]; other site 521674002664 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 521674002665 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 521674002666 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 521674002667 TAP-like protein; Region: Abhydrolase_4; pfam08386 521674002668 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674002669 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674002670 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674002671 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674002672 structural tetrad; other site 521674002673 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 521674002674 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674002675 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674002676 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 521674002677 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521674002678 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521674002679 protein binding site [polypeptide binding]; other site 521674002680 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521674002681 Catalytic dyad [active] 521674002682 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 521674002683 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674002684 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 521674002685 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 521674002686 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674002687 Cytochrome c; Region: Cytochrom_C; pfam00034 521674002688 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 521674002689 MG2 domain; Region: A2M_N; pfam01835 521674002690 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 521674002691 Alpha-2-macroglobulin family; Region: A2M; pfam00207 521674002692 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 521674002693 surface patch; other site 521674002694 thioester region; other site 521674002695 specificity defining residues; other site 521674002696 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521674002697 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 521674002698 Ligand binding site; other site 521674002699 Putative Catalytic site; other site 521674002700 DXD motif; other site 521674002701 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 521674002702 Quinolinate synthetase A protein; Region: NadA; pfam02445 521674002703 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 521674002704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521674002705 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674002706 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 521674002707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521674002708 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 521674002709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674002710 Coenzyme A binding pocket [chemical binding]; other site 521674002711 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 521674002712 active site 521674002713 catalytic triad [active] 521674002714 oxyanion hole [active] 521674002715 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674002716 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521674002717 AAA domain; Region: AAA_23; pfam13476 521674002718 Walker A/P-loop; other site 521674002719 ATP binding site [chemical binding]; other site 521674002720 Q-loop/lid; other site 521674002721 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521674002722 ABC transporter signature motif; other site 521674002723 Walker B; other site 521674002724 D-loop; other site 521674002725 H-loop/switch region; other site 521674002726 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 521674002727 HEAT repeats; Region: HEAT_2; pfam13646 521674002728 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 521674002729 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674002730 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 521674002731 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 521674002732 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521674002733 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 521674002734 putative dimer interface [polypeptide binding]; other site 521674002735 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521674002736 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 521674002737 putative dimer interface [polypeptide binding]; other site 521674002738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521674002739 Ligand Binding Site [chemical binding]; other site 521674002740 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 521674002741 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 521674002742 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 521674002743 catalytic residues [active] 521674002744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674002745 S-adenosylmethionine binding site [chemical binding]; other site 521674002746 DsrE/DsrF-like family; Region: DrsE; pfam02635 521674002747 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 521674002748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521674002749 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521674002750 active site residue [active] 521674002751 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521674002752 active site residue [active] 521674002753 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521674002754 active site residue [active] 521674002755 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521674002756 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 521674002757 active site 521674002758 Int/Topo IB signature motif; other site 521674002759 YTV; Region: YTV; pfam07639 521674002760 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 521674002761 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521674002762 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 521674002763 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 521674002764 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 521674002765 putative active site pocket [active] 521674002766 metal binding site [ion binding]; metal-binding site 521674002767 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521674002768 active site 521674002769 phosphorylation site [posttranslational modification] 521674002770 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521674002771 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 521674002772 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 521674002773 putative valine binding site [chemical binding]; other site 521674002774 dimer interface [polypeptide binding]; other site 521674002775 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 521674002776 ketol-acid reductoisomerase; Provisional; Region: PRK05479 521674002777 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 521674002778 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 521674002779 Peptidase family M41; Region: Peptidase_M41; pfam01434 521674002780 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521674002781 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521674002782 hinge; other site 521674002783 active site 521674002784 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674002785 Domain of unknown function (DUF386); Region: DUF386; cl01047 521674002786 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521674002787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674002788 putative DNA binding site [nucleotide binding]; other site 521674002789 putative Zn2+ binding site [ion binding]; other site 521674002790 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 521674002791 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 521674002792 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 521674002793 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 521674002794 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 521674002795 active site 521674002796 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 521674002797 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521674002798 NAD binding site [chemical binding]; other site 521674002799 dimer interface [polypeptide binding]; other site 521674002800 substrate binding site [chemical binding]; other site 521674002801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521674002802 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 521674002803 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 521674002804 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674002805 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674002806 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674002807 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674002808 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521674002809 Metal-binding active site; metal-binding site 521674002810 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 521674002811 CARDB; Region: CARDB; pfam07705 521674002812 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 521674002813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 521674002814 active site 521674002815 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674002816 Sulfatase; Region: Sulfatase; pfam00884 521674002817 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 521674002818 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 521674002819 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 521674002820 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 521674002821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002822 ATP binding site [chemical binding]; other site 521674002823 putative Mg++ binding site [ion binding]; other site 521674002824 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 521674002825 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521674002826 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 521674002827 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521674002828 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 521674002829 HsdM N-terminal domain; Region: HsdM_N; pfam12161 521674002830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674002831 S-adenosylmethionine binding site [chemical binding]; other site 521674002832 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674002833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674002834 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674002835 catalytic residues [active] 521674002836 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 521674002837 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 521674002838 active site 521674002839 catalytic residues [active] 521674002840 metal binding site [ion binding]; metal-binding site 521674002841 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 521674002842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002843 ATP binding site [chemical binding]; other site 521674002844 putative Mg++ binding site [ion binding]; other site 521674002845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002846 nucleotide binding region [chemical binding]; other site 521674002847 ATP-binding site [chemical binding]; other site 521674002848 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 521674002849 HRDC domain; Region: HRDC; pfam00570 521674002850 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521674002851 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 521674002852 putative dimer interface [polypeptide binding]; other site 521674002853 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 521674002854 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674002855 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674002856 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 521674002857 Protein export membrane protein; Region: SecD_SecF; cl14618 521674002858 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 521674002859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674002860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674002861 active site 521674002862 ATP binding site [chemical binding]; other site 521674002863 substrate binding site [chemical binding]; other site 521674002864 activation loop (A-loop); other site 521674002865 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521674002866 Part of AAA domain; Region: AAA_19; pfam13245 521674002867 Family description; Region: UvrD_C_2; pfam13538 521674002868 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521674002869 Glycoprotease family; Region: Peptidase_M22; pfam00814 521674002870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 521674002871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674002872 Coenzyme A binding pocket [chemical binding]; other site 521674002873 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 521674002874 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 521674002875 G1 box; other site 521674002876 putative GEF interaction site [polypeptide binding]; other site 521674002877 GTP/Mg2+ binding site [chemical binding]; other site 521674002878 Switch I region; other site 521674002879 G2 box; other site 521674002880 G3 box; other site 521674002881 Switch II region; other site 521674002882 G4 box; other site 521674002883 G5 box; other site 521674002884 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 521674002885 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 521674002886 hypothetical protein; Provisional; Region: PRK02227 521674002887 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 521674002888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674002889 motif II; other site 521674002890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521674002891 TPR motif; other site 521674002892 binding surface 521674002893 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521674002894 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674002895 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674002896 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674002897 protein binding site [polypeptide binding]; other site 521674002898 thiamine monophosphate kinase; Provisional; Region: PRK05731 521674002899 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 521674002900 ATP binding site [chemical binding]; other site 521674002901 dimerization interface [polypeptide binding]; other site 521674002902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674002903 ATP binding site [chemical binding]; other site 521674002904 putative Mg++ binding site [ion binding]; other site 521674002905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002906 nucleotide binding region [chemical binding]; other site 521674002907 ATP-binding site [chemical binding]; other site 521674002908 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 521674002909 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 521674002910 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 521674002911 catalytic triad [active] 521674002912 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 521674002913 POT family; Region: PTR2; cl17359 521674002914 POT family; Region: PTR2; cl17359 521674002915 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 521674002916 putative hydrophobic ligand binding site [chemical binding]; other site 521674002917 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674002918 Phosphoglycerate kinase; Region: PGK; pfam00162 521674002919 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521674002920 substrate binding site [chemical binding]; other site 521674002921 hinge regions; other site 521674002922 ADP binding site [chemical binding]; other site 521674002923 catalytic site [active] 521674002924 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 521674002925 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 521674002926 trimer interface [polypeptide binding]; other site 521674002927 putative metal binding site [ion binding]; other site 521674002928 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 521674002929 Zn binding site [ion binding]; other site 521674002930 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 521674002931 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674002932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674002933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674002934 DNA binding residues [nucleotide binding] 521674002935 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 521674002936 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521674002937 ATP binding site [chemical binding]; other site 521674002938 Mg++ binding site [ion binding]; other site 521674002939 motif III; other site 521674002940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674002941 nucleotide binding region [chemical binding]; other site 521674002942 ATP-binding site [chemical binding]; other site 521674002943 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 521674002944 putative RNA binding site [nucleotide binding]; other site 521674002945 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674002946 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674002947 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674002948 structural tetrad; other site 521674002949 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 521674002950 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 521674002951 active site 521674002952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674002953 active site 521674002954 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 521674002955 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 521674002956 active site 521674002957 PHP Thumb interface [polypeptide binding]; other site 521674002958 metal binding site [ion binding]; metal-binding site 521674002959 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521674002960 generic binding surface I; other site 521674002961 generic binding surface II; other site 521674002962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674002963 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 521674002964 putative ADP-binding pocket [chemical binding]; other site 521674002965 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 521674002966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 521674002967 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 521674002968 L-aspartate oxidase; Provisional; Region: PRK06175 521674002969 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 521674002970 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 521674002971 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521674002972 IHF dimer interface [polypeptide binding]; other site 521674002973 IHF - DNA interface [nucleotide binding]; other site 521674002974 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674002975 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674002976 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 521674002977 Colicin V production protein; Region: Colicin_V; pfam02674 521674002978 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 521674002979 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 521674002980 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674002981 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 521674002982 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 521674002983 putative ADP-binding pocket [chemical binding]; other site 521674002984 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 521674002985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674002986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674002987 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 521674002988 xylose isomerase; Provisional; Region: PRK05474 521674002989 xylose isomerase; Region: xylose_isom_A; TIGR02630 521674002990 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521674002991 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521674002992 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 521674002993 active site 521674002994 (T/H)XGH motif; other site 521674002995 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 521674002996 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674002997 putative catalytic residue [active] 521674002998 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 521674002999 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674003000 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674003001 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 521674003002 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674003003 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674003004 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 521674003005 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 521674003006 tRNA; other site 521674003007 putative tRNA binding site [nucleotide binding]; other site 521674003008 putative NADP binding site [chemical binding]; other site 521674003009 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 521674003010 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 521674003011 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 521674003012 putative active site [active] 521674003013 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 521674003014 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521674003015 FMN binding site [chemical binding]; other site 521674003016 dimer interface [polypeptide binding]; other site 521674003017 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003018 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 521674003019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521674003020 acyl-activating enzyme (AAE) consensus motif; other site 521674003021 AMP binding site [chemical binding]; other site 521674003022 active site 521674003023 CoA binding site [chemical binding]; other site 521674003024 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674003025 phosphopeptide binding site; other site 521674003026 serine O-acetyltransferase; Region: cysE; TIGR01172 521674003027 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 521674003028 trimer interface [polypeptide binding]; other site 521674003029 active site 521674003030 substrate binding site [chemical binding]; other site 521674003031 CoA binding site [chemical binding]; other site 521674003032 CAAX protease self-immunity; Region: Abi; pfam02517 521674003033 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521674003034 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521674003035 Ligand binding site; other site 521674003036 Putative Catalytic site; other site 521674003037 DXD motif; other site 521674003038 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 521674003039 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521674003040 active site 521674003041 substrate binding site [chemical binding]; other site 521674003042 metal binding site [ion binding]; metal-binding site 521674003043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674003044 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674003045 phosphopeptide binding site; other site 521674003046 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521674003047 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674003048 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674003049 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 521674003050 Glutaminase; Region: Glutaminase; cl00907 521674003051 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 521674003052 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 521674003053 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521674003054 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521674003055 trimerization site [polypeptide binding]; other site 521674003056 active site 521674003057 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521674003058 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521674003059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674003060 catalytic residue [active] 521674003061 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 521674003062 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 521674003063 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 521674003064 ATP-grasp domain; Region: ATP-grasp; pfam02222 521674003065 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 521674003066 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 521674003067 putative active site [active] 521674003068 putative PHP Thumb interface [polypeptide binding]; other site 521674003069 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521674003070 generic binding surface II; other site 521674003071 generic binding surface I; other site 521674003072 DNA Polymerase Y-family; Region: PolY_like; cd03468 521674003073 active site 521674003074 DNA binding site [nucleotide binding] 521674003075 Uncharacterized conserved protein [Function unknown]; Region: COG4544 521674003076 Uncharacterized conserved protein [Function unknown]; Region: COG2135 521674003077 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 521674003078 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 521674003079 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 521674003080 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 521674003081 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 521674003082 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 521674003083 4Fe-4S binding domain; Region: Fer4; cl02805 521674003084 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 521674003085 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 521674003086 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 521674003087 Predicted membrane protein [Function unknown]; Region: COG3463 521674003088 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 521674003089 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 521674003090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674003091 active site 521674003092 HIGH motif; other site 521674003093 nucleotide binding site [chemical binding]; other site 521674003094 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521674003095 KMSK motif region; other site 521674003096 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521674003097 tRNA binding surface [nucleotide binding]; other site 521674003098 anticodon binding site; other site 521674003099 Oligomerisation domain; Region: Oligomerisation; pfam02410 521674003100 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 521674003101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521674003102 Beta-Casp domain; Region: Beta-Casp; smart01027 521674003103 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 521674003104 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 521674003105 glutaminase active site [active] 521674003106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521674003107 dimer interface [polypeptide binding]; other site 521674003108 active site 521674003109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 521674003110 dimer interface [polypeptide binding]; other site 521674003111 active site 521674003112 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674003113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674003114 NAD(P) binding site [chemical binding]; other site 521674003115 active site 521674003116 PAS domain S-box; Region: sensory_box; TIGR00229 521674003117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003118 putative active site [active] 521674003119 heme pocket [chemical binding]; other site 521674003120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674003121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674003122 dimer interface [polypeptide binding]; other site 521674003123 phosphorylation site [posttranslational modification] 521674003124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674003125 ATP binding site [chemical binding]; other site 521674003126 Mg2+ binding site [ion binding]; other site 521674003127 G-X-G motif; other site 521674003128 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674003129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674003130 active site 521674003131 phosphorylation site [posttranslational modification] 521674003132 intermolecular recognition site; other site 521674003133 dimerization interface [polypeptide binding]; other site 521674003134 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 521674003135 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 521674003136 Preprotein translocase subunit; Region: YajC; pfam02699 521674003137 protein-export membrane protein SecD; Region: secD; TIGR01129 521674003138 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 521674003139 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 521674003140 Protein export membrane protein; Region: SecD_SecF; cl14618 521674003141 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 521674003142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674003143 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 521674003144 Walker A motif; other site 521674003145 ATP binding site [chemical binding]; other site 521674003146 Walker B motif; other site 521674003147 arginine finger; other site 521674003148 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 521674003149 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; Region: 17beta-HSD1_like_SDR_c; cd05356 521674003150 putative NAD(P) binding site [chemical binding]; other site 521674003151 active site 521674003152 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521674003153 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521674003154 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521674003155 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 521674003156 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 521674003157 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 521674003158 homodimer interface [polypeptide binding]; other site 521674003159 metal binding site [ion binding]; metal-binding site 521674003160 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 521674003161 homodimer interface [polypeptide binding]; other site 521674003162 active site 521674003163 putative chemical substrate binding site [chemical binding]; other site 521674003164 metal binding site [ion binding]; metal-binding site 521674003165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521674003166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 521674003167 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003168 TrbC/VIRB2 family; Region: TrbC; cl01583 521674003169 lipoprotein signal peptidase; Provisional; Region: PRK14787 521674003170 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 521674003171 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521674003172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521674003173 P-loop; other site 521674003174 Magnesium ion binding site [ion binding]; other site 521674003175 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521674003176 Magnesium ion binding site [ion binding]; other site 521674003177 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 521674003178 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 521674003179 molybdopterin cofactor binding site; other site 521674003180 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 521674003181 putative molybdopterin cofactor binding site; other site 521674003182 hypothetical protein; Provisional; Region: PRK09256 521674003183 Type II/IV secretion system protein; Region: T2SE; pfam00437 521674003184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674003185 Walker A motif; other site 521674003186 ATP binding site [chemical binding]; other site 521674003187 Walker B motif; other site 521674003188 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521674003189 dihydrodipicolinate synthase; Region: dapA; TIGR00674 521674003190 dimer interface [polypeptide binding]; other site 521674003191 active site 521674003192 catalytic residue [active] 521674003193 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521674003194 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521674003195 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521674003196 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 521674003197 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 521674003198 dimer interface [polypeptide binding]; other site 521674003199 active site 521674003200 catalytic residue [active] 521674003201 metal binding site [ion binding]; metal-binding site 521674003202 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 521674003203 primosome assembly protein PriA; Validated; Region: PRK05580 521674003204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674003205 ATP binding site [chemical binding]; other site 521674003206 putative Mg++ binding site [ion binding]; other site 521674003207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674003208 nucleotide binding region [chemical binding]; other site 521674003209 ATP-binding site [chemical binding]; other site 521674003210 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521674003211 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 521674003212 oligomer interface [polypeptide binding]; other site 521674003213 active site 521674003214 metal binding site [ion binding]; metal-binding site 521674003215 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 521674003216 Part of AAA domain; Region: AAA_19; pfam13245 521674003217 Family description; Region: UvrD_C_2; pfam13538 521674003218 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521674003219 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521674003220 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674003221 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674003222 protein binding site [polypeptide binding]; other site 521674003223 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 521674003224 protein binding site [polypeptide binding]; other site 521674003225 MEKHLA domain; Region: MEKHLA; pfam08670 521674003226 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 521674003227 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 521674003228 Trehalose utilisation; Region: ThuA; pfam06283 521674003229 conserved cys residue [active] 521674003230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674003231 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 521674003232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674003233 ATP binding site [chemical binding]; other site 521674003234 putative Mg++ binding site [ion binding]; other site 521674003235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674003236 nucleotide binding region [chemical binding]; other site 521674003237 ATP-binding site [chemical binding]; other site 521674003238 Helicase associated domain (HA2); Region: HA2; pfam04408 521674003239 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 521674003240 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 521674003241 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 521674003242 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 521674003243 Rhomboid family; Region: Rhomboid; pfam01694 521674003244 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 521674003245 Fe-S cluster binding site [ion binding]; other site 521674003246 DNA binding site [nucleotide binding] 521674003247 active site 521674003248 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 521674003249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674003250 motif II; other site 521674003251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521674003252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521674003253 nucleotide binding site [chemical binding]; other site 521674003254 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674003255 anti sigma factor interaction site; other site 521674003256 regulatory phosphorylation site [posttranslational modification]; other site 521674003257 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 521674003258 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 521674003259 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 521674003260 TrkA-N domain; Region: TrkA_N; pfam02254 521674003261 TrkA-C domain; Region: TrkA_C; pfam02080 521674003262 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 521674003263 Aspartase; Region: Aspartase; cd01357 521674003264 active sites [active] 521674003265 tetramer interface [polypeptide binding]; other site 521674003266 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 521674003267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674003268 Walker A/P-loop; other site 521674003269 ATP binding site [chemical binding]; other site 521674003270 Q-loop/lid; other site 521674003271 ABC transporter signature motif; other site 521674003272 Walker B; other site 521674003273 D-loop; other site 521674003274 H-loop/switch region; other site 521674003275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674003276 TPR motif; other site 521674003277 Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785 521674003278 binding surface 521674003279 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 521674003280 active site 521674003281 catalytic residues [active] 521674003282 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521674003283 active site 521674003284 metal binding site [ion binding]; metal-binding site 521674003285 homotetramer interface [polypeptide binding]; other site 521674003286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 521674003287 FIST N domain; Region: FIST; smart00897 521674003288 FIST C domain; Region: FIST_C; pfam10442 521674003289 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 521674003290 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 521674003291 tandem repeat interface [polypeptide binding]; other site 521674003292 oligomer interface [polypeptide binding]; other site 521674003293 active site residues [active] 521674003294 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 521674003295 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 521674003296 tandem repeat interface [polypeptide binding]; other site 521674003297 oligomer interface [polypeptide binding]; other site 521674003298 active site residues [active] 521674003299 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 521674003300 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 521674003301 peptide binding site [polypeptide binding]; other site 521674003302 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521674003303 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521674003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674003305 dimer interface [polypeptide binding]; other site 521674003306 conserved gate region; other site 521674003307 putative PBP binding loops; other site 521674003308 ABC-ATPase subunit interface; other site 521674003309 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521674003310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521674003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674003312 dimer interface [polypeptide binding]; other site 521674003313 conserved gate region; other site 521674003314 putative PBP binding loops; other site 521674003315 ABC-ATPase subunit interface; other site 521674003316 acetolactate synthase; Region: PLN02470 521674003317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 521674003318 PYR/PP interface [polypeptide binding]; other site 521674003319 dimer interface [polypeptide binding]; other site 521674003320 TPP binding site [chemical binding]; other site 521674003321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 521674003322 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 521674003323 TPP-binding site [chemical binding]; other site 521674003324 dimer interface [polypeptide binding]; other site 521674003325 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674003326 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 521674003327 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674003328 CCC1-related family of proteins; Region: CCC1_like; cl00278 521674003329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674003330 binding surface 521674003331 TPR motif; other site 521674003332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674003333 TPR motif; other site 521674003334 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674003335 binding surface 521674003336 phosphoglucomutase; Validated; Region: PRK07564 521674003337 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 521674003338 active site 521674003339 substrate binding site [chemical binding]; other site 521674003340 metal binding site [ion binding]; metal-binding site 521674003341 4-alpha-glucanotransferase; Provisional; Region: PRK14508 521674003342 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 521674003343 dinuclear metal binding motif [ion binding]; other site 521674003344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674003345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674003346 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674003347 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 521674003348 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 521674003349 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674003350 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674003351 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674003352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674003353 Walker A motif; other site 521674003354 ATP binding site [chemical binding]; other site 521674003355 Walker B motif; other site 521674003356 arginine finger; other site 521674003357 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674003358 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674003359 metal ion-dependent adhesion site (MIDAS); other site 521674003360 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 521674003361 domain_subunit interface; other site 521674003362 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 521674003363 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 521674003364 purine monophosphate binding site [chemical binding]; other site 521674003365 dimer interface [polypeptide binding]; other site 521674003366 putative catalytic residues [active] 521674003367 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 521674003368 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521674003369 Porin subfamily; Region: Porin_2; pfam02530 521674003370 aspartate kinase; Provisional; Region: PRK07431 521674003371 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 521674003372 putative nucleotide binding site [chemical binding]; other site 521674003373 putative catalytic residues [active] 521674003374 putative Mg ion binding site [ion binding]; other site 521674003375 putative aspartate binding site [chemical binding]; other site 521674003376 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 521674003377 putative allosteric regulatory site; other site 521674003378 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 521674003379 putative allosteric regulatory residue; other site 521674003380 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 521674003381 putative allosteric regulatory site; other site 521674003382 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 521674003383 putative allosteric regulatory residue; other site 521674003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674003385 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 521674003386 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 521674003387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674003388 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521674003389 active site 521674003390 metal binding site [ion binding]; metal-binding site 521674003391 photolyase PhrII; Region: phr2; TIGR00591 521674003392 DNA photolyase; Region: DNA_photolyase; pfam00875 521674003393 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521674003394 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 521674003395 Cl- selectivity filter; other site 521674003396 Cl- binding residues [ion binding]; other site 521674003397 pore gating glutamate residue; other site 521674003398 dimer interface [polypeptide binding]; other site 521674003399 FOG: CBS domain [General function prediction only]; Region: COG0517 521674003400 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521674003401 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 521674003402 Methane oxygenase PmoA; Region: PmoA; pfam14100 521674003403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521674003404 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521674003405 substrate binding pocket [chemical binding]; other site 521674003406 Domain of unknown function (DUF309); Region: DUF309; pfam03745 521674003407 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674003408 HEAT repeats; Region: HEAT_2; pfam13646 521674003409 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 521674003410 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674003411 Domain of unknown function (DUF303); Region: DUF303; pfam03629 521674003412 Cytochrome c; Region: Cytochrom_C; cl11414 521674003413 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 521674003414 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 521674003415 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 521674003416 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 521674003417 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 521674003418 putative NAD(P) binding site [chemical binding]; other site 521674003419 putative active site [active] 521674003420 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 521674003421 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 521674003422 thioester formation/cholesterol transfer; other site 521674003423 protein-splicing catalytic site; other site 521674003424 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 521674003425 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674003426 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 521674003427 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 521674003428 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 521674003429 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674003430 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674003431 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674003432 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674003433 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674003434 structural tetrad; other site 521674003435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521674003436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674003437 S-adenosylmethionine binding site [chemical binding]; other site 521674003438 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674003439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521674003440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521674003441 metal binding site [ion binding]; metal-binding site 521674003442 active site 521674003443 I-site; other site 521674003444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 521674003445 large tegument protein UL36; Provisional; Region: PHA03247 521674003446 large tegument protein UL36; Provisional; Region: PHA03247 521674003447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674003448 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674003449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674003450 DNA binding residues [nucleotide binding] 521674003451 Src homology 2 (SH2) domain; Region: SH2; cl15255 521674003452 hydrophobic binding pocket [polypeptide binding]; other site 521674003453 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674003454 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674003455 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674003456 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521674003457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521674003458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674003459 S-adenosylmethionine binding site [chemical binding]; other site 521674003460 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 521674003461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521674003462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674003463 Coenzyme A binding pocket [chemical binding]; other site 521674003464 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 521674003465 Uncharacterized conserved protein [Function unknown]; Region: COG5361 521674003466 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 521674003467 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 521674003468 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 521674003469 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 521674003470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674003471 catalytic residue [active] 521674003472 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 521674003473 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 521674003474 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674003475 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674003476 active site 521674003477 ATP binding site [chemical binding]; other site 521674003478 substrate binding site [chemical binding]; other site 521674003479 activation loop (A-loop); other site 521674003480 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 521674003481 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 521674003482 dimer interface [polypeptide binding]; other site 521674003483 NADP binding site [chemical binding]; other site 521674003484 catalytic residues [active] 521674003485 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 521674003486 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 521674003487 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 521674003488 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 521674003489 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 521674003490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674003491 active site 521674003492 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674003493 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003494 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521674003495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674003496 active site 521674003497 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521674003498 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 521674003499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521674003500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674003501 active site 521674003502 phosphorylation site [posttranslational modification] 521674003503 intermolecular recognition site; other site 521674003504 dimerization interface [polypeptide binding]; other site 521674003505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521674003506 DNA binding site [nucleotide binding] 521674003507 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 521674003508 PhoU domain; Region: PhoU; pfam01895 521674003509 PhoU domain; Region: PhoU; pfam01895 521674003510 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 521674003511 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 521674003512 Walker A/P-loop; other site 521674003513 ATP binding site [chemical binding]; other site 521674003514 Q-loop/lid; other site 521674003515 ABC transporter signature motif; other site 521674003516 Walker B; other site 521674003517 D-loop; other site 521674003518 H-loop/switch region; other site 521674003519 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 521674003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674003521 dimer interface [polypeptide binding]; other site 521674003522 conserved gate region; other site 521674003523 putative PBP binding loops; other site 521674003524 ABC-ATPase subunit interface; other site 521674003525 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 521674003526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674003527 dimer interface [polypeptide binding]; other site 521674003528 conserved gate region; other site 521674003529 putative PBP binding loops; other site 521674003530 ABC-ATPase subunit interface; other site 521674003531 PBP superfamily domain; Region: PBP_like_2; cl17296 521674003532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521674003533 dimerization interface [polypeptide binding]; other site 521674003534 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521674003535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003536 putative active site [active] 521674003537 heme pocket [chemical binding]; other site 521674003538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674003539 dimer interface [polypeptide binding]; other site 521674003540 phosphorylation site [posttranslational modification] 521674003541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674003542 ATP binding site [chemical binding]; other site 521674003543 Mg2+ binding site [ion binding]; other site 521674003544 G-X-G motif; other site 521674003545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 521674003546 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 521674003547 Uncharacterized conserved protein [Function unknown]; Region: COG2308 521674003548 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674003549 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 521674003550 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674003551 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 521674003552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 521674003553 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 521674003554 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674003555 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 521674003556 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674003557 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 521674003558 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 521674003559 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003560 Sulfatase; Region: Sulfatase; pfam00884 521674003561 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 521674003562 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 521674003563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521674003564 substrate binding site [chemical binding]; other site 521674003565 oxyanion hole (OAH) forming residues; other site 521674003566 trimer interface [polypeptide binding]; other site 521674003567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 521674003568 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 521674003569 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521674003570 nucleotide binding site [chemical binding]; other site 521674003571 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674003572 SBD interface [polypeptide binding]; other site 521674003573 glutaminase; Reviewed; Region: PRK12356 521674003574 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 521674003575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674003576 putative substrate translocation pore; other site 521674003577 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 521674003578 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521674003579 peptidase T-like protein; Region: PepT-like; TIGR01883 521674003580 metal binding site [ion binding]; metal-binding site 521674003581 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 521674003582 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 521674003583 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 521674003584 transmembrane helices; other site 521674003585 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521674003586 TrkA-C domain; Region: TrkA_C; pfam02080 521674003587 TrkA-C domain; Region: TrkA_C; pfam02080 521674003588 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 521674003589 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 521674003590 AAA domain; Region: AAA_33; pfam13671 521674003591 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 521674003592 Uncharacterized conserved protein [Function unknown]; Region: COG4021 521674003593 Thg1 C terminal domain; Region: Thg1C; pfam14413 521674003594 AAA domain; Region: AAA_33; pfam13671 521674003595 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 521674003596 NAD-dependent deacetylase; Provisional; Region: PRK00481 521674003597 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 521674003598 Sulfatase; Region: Sulfatase; cl17466 521674003599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003600 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003601 Sulfatase; Region: Sulfatase; pfam00884 521674003602 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 521674003603 ATP-NAD kinase; Region: NAD_kinase; pfam01513 521674003604 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 521674003605 Peptidase family M50; Region: Peptidase_M50; pfam02163 521674003606 active site 521674003607 putative substrate binding region [chemical binding]; other site 521674003608 intracellular protease, PfpI family; Region: PfpI; TIGR01382 521674003609 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 521674003610 proposed catalytic triad [active] 521674003611 conserved cys residue [active] 521674003612 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674003613 Protein of unknown function (DUF229); Region: DUF229; pfam02995 521674003614 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674003615 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674003616 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674003617 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 521674003618 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 521674003619 dimer interface [polypeptide binding]; other site 521674003620 active site 521674003621 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 521674003622 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674003623 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674003624 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521674003625 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674003626 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 521674003627 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 521674003628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674003629 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674003630 active site 521674003631 ATP binding site [chemical binding]; other site 521674003632 substrate binding site [chemical binding]; other site 521674003633 activation loop (A-loop); other site 521674003634 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674003635 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674003636 catalytic residues [active] 521674003637 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 521674003638 gamma-glutamyl kinase; Provisional; Region: PRK05429 521674003639 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 521674003640 nucleotide binding site [chemical binding]; other site 521674003641 homotetrameric interface [polypeptide binding]; other site 521674003642 putative phosphate binding site [ion binding]; other site 521674003643 putative allosteric binding site; other site 521674003644 PUA domain; Region: PUA; pfam01472 521674003645 Haemolytic domain; Region: Haemolytic; pfam01809 521674003646 Ribonuclease P; Region: Ribonuclease_P; pfam00825 521674003647 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 521674003648 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 521674003649 active site 521674003650 catalytic residue [active] 521674003651 dimer interface [polypeptide binding]; other site 521674003652 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 521674003653 NAD(P) binding pocket [chemical binding]; other site 521674003654 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 521674003655 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 521674003656 dimer interface [polypeptide binding]; other site 521674003657 allosteric magnesium binding site [ion binding]; other site 521674003658 active site 521674003659 aspartate-rich active site metal binding site; other site 521674003660 Schiff base residues; other site 521674003661 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 521674003662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674003663 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 521674003664 active site 521674003665 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674003666 anti sigma factor interaction site; other site 521674003667 regulatory phosphorylation site [posttranslational modification]; other site 521674003668 Beta-lactamase; Region: Beta-lactamase; pfam00144 521674003669 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521674003670 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674003671 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674003672 catalytic residues [active] 521674003673 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 521674003674 active site 521674003675 SAM binding site [chemical binding]; other site 521674003676 homodimer interface [polypeptide binding]; other site 521674003677 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 521674003678 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 521674003679 active site 521674003680 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 521674003681 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674003682 putative catalytic residue [active] 521674003683 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 521674003684 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 521674003685 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 521674003686 metal binding site [ion binding]; metal-binding site 521674003687 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521674003688 hydrophobic ligand binding site; other site 521674003689 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521674003690 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 521674003691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674003692 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674003693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674003694 active site 521674003695 metal binding site [ion binding]; metal-binding site 521674003696 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674003697 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674003698 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003699 Sulfatase; Region: Sulfatase; cl17466 521674003700 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003701 Sulfatase; Region: Sulfatase; cl17466 521674003702 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003703 Sulfatase; Region: Sulfatase; cl17466 521674003704 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003705 Sulfatase; Region: Sulfatase; pfam00884 521674003706 short chain dehydrogenase; Validated; Region: PRK08264 521674003707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674003708 NAD(P) binding site [chemical binding]; other site 521674003709 active site 521674003710 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 521674003711 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 521674003712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674003713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674003714 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 521674003715 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 521674003716 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 521674003717 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521674003718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674003719 Zn2+ binding site [ion binding]; other site 521674003720 Mg2+ binding site [ion binding]; other site 521674003721 pteridine reductase; Provisional; Region: PRK09135 521674003722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674003723 NAD(P) binding site [chemical binding]; other site 521674003724 active site 521674003725 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 521674003726 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 521674003727 active site 521674003728 metal binding site [ion binding]; metal-binding site 521674003729 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521674003730 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 521674003731 NodB motif; other site 521674003732 putative active site [active] 521674003733 putative catalytic site [active] 521674003734 putative Zn binding site [ion binding]; other site 521674003735 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674003736 Cytochrome c; Region: Cytochrom_C; pfam00034 521674003737 Cytochrome c; Region: Cytochrom_C; pfam00034 521674003738 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 521674003739 Outer membrane efflux protein; Region: OEP; pfam02321 521674003740 Outer membrane efflux protein; Region: OEP; pfam02321 521674003741 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 521674003742 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674003743 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674003744 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 521674003745 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 521674003746 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 521674003747 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 521674003748 Rhomboid family; Region: Rhomboid; pfam01694 521674003749 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 521674003750 heterotetramer interface [polypeptide binding]; other site 521674003751 active site pocket [active] 521674003752 cleavage site 521674003753 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 521674003754 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844 521674003755 O-methyltransferase; Region: Methyltransf_2; pfam00891 521674003756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674003757 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521674003758 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521674003759 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521674003760 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521674003761 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521674003762 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521674003763 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521674003764 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521674003765 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674003766 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674003767 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674003768 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674003769 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674003770 RHS Repeat; Region: RHS_repeat; cl11982 521674003771 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521674003772 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674003773 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521674003774 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521674003775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674003776 catalytic residue [active] 521674003777 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521674003778 putative active site [active] 521674003779 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674003780 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674003781 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 521674003782 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674003783 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521674003784 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674003785 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674003786 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674003787 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 521674003788 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521674003789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674003790 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521674003791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674003792 DNA binding residues [nucleotide binding] 521674003793 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003794 ribosomal protein S1; Region: rpsA; TIGR00717 521674003795 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521674003796 RNA binding site [nucleotide binding]; other site 521674003797 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521674003798 RNA binding site [nucleotide binding]; other site 521674003799 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521674003800 RNA binding site [nucleotide binding]; other site 521674003801 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521674003802 RNA binding site [nucleotide binding]; other site 521674003803 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521674003804 RNA binding site [nucleotide binding]; other site 521674003805 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 521674003806 RNA binding site [nucleotide binding]; other site 521674003807 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 521674003808 active site 521674003809 catalytic residues [active] 521674003810 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521674003811 Ligand binding site; other site 521674003812 Putative Catalytic site; other site 521674003813 DXD motif; other site 521674003814 FtsH Extracellular; Region: FtsH_ext; pfam06480 521674003815 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521674003816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674003817 Walker A motif; other site 521674003818 ATP binding site [chemical binding]; other site 521674003819 Walker B motif; other site 521674003820 arginine finger; other site 521674003821 Peptidase family M41; Region: Peptidase_M41; pfam01434 521674003822 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003823 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674003824 Trehalose utilisation; Region: ThuA; pfam06283 521674003825 TPR repeat; Region: TPR_11; pfam13414 521674003826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674003827 TPR motif; other site 521674003828 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 521674003829 Ligand binding site; other site 521674003830 Putative Catalytic site; other site 521674003831 DXD motif; other site 521674003832 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 521674003833 oligomerization interface [polypeptide binding]; other site 521674003834 active site 521674003835 metal binding site [ion binding]; metal-binding site 521674003836 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521674003837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521674003838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521674003839 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521674003840 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521674003841 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 521674003842 active site 521674003843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674003844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674003845 NAD(P) binding site [chemical binding]; other site 521674003846 active site 521674003847 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521674003848 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674003849 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 521674003850 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674003851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674003852 active site 521674003853 phosphorylation site [posttranslational modification] 521674003854 intermolecular recognition site; other site 521674003855 dimerization interface [polypeptide binding]; other site 521674003856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674003857 Walker A motif; other site 521674003858 ATP binding site [chemical binding]; other site 521674003859 Walker B motif; other site 521674003860 arginine finger; other site 521674003861 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674003862 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674003863 membrane-attack complex/perforin (MACPF) Superfamily; Provisional; Region: PTZ00482 521674003864 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674003865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521674003866 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521674003867 active site 521674003868 catalytic tetrad [active] 521674003869 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 521674003870 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 521674003871 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674003872 Sulfatase; Region: Sulfatase; pfam00884 521674003873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521674003874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674003875 ABC transporter; Region: ABC_tran_2; pfam12848 521674003876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674003877 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 521674003878 ABC transporter ATPase component; Reviewed; Region: PRK11147 521674003879 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674003880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674003881 ABC transporter; Region: ABC_tran_2; pfam12848 521674003882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674003883 PAS domain; Region: PAS; smart00091 521674003884 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674003885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003886 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674003887 putative active site [active] 521674003888 heme pocket [chemical binding]; other site 521674003889 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674003890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003891 putative active site [active] 521674003892 heme pocket [chemical binding]; other site 521674003893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003894 putative active site [active] 521674003895 heme pocket [chemical binding]; other site 521674003896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674003897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674003898 putative active site [active] 521674003899 heme pocket [chemical binding]; other site 521674003900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674003901 dimer interface [polypeptide binding]; other site 521674003902 phosphorylation site [posttranslational modification] 521674003903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674003904 ATP binding site [chemical binding]; other site 521674003905 Mg2+ binding site [ion binding]; other site 521674003906 G-X-G motif; other site 521674003907 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 521674003908 glycyl-tRNA synthetase; Provisional; Region: PRK04173 521674003909 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521674003910 motif 1; other site 521674003911 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 521674003912 active site 521674003913 motif 2; other site 521674003914 motif 3; other site 521674003915 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 521674003916 anticodon binding site; other site 521674003917 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 521674003918 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521674003919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674003920 FeS/SAM binding site; other site 521674003921 TRAM domain; Region: TRAM; pfam01938 521674003922 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 521674003923 acyl transferase; Provisional; Region: luxD; PRK13604 521674003924 GTP-binding protein YchF; Reviewed; Region: PRK09601 521674003925 YchF GTPase; Region: YchF; cd01900 521674003926 G1 box; other site 521674003927 GTP/Mg2+ binding site [chemical binding]; other site 521674003928 Switch I region; other site 521674003929 G2 box; other site 521674003930 Switch II region; other site 521674003931 G3 box; other site 521674003932 G4 box; other site 521674003933 G5 box; other site 521674003934 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521674003935 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 521674003936 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 521674003937 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 521674003938 dimer interface [polypeptide binding]; other site 521674003939 active site 521674003940 heme binding site [chemical binding]; other site 521674003941 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 521674003942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521674003943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521674003944 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 521674003945 dimerization interface [polypeptide binding]; other site 521674003946 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 521674003947 catalytic triad [active] 521674003948 conserved cis-peptide bond; other site 521674003949 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674003950 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674003951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 521674003952 PAS fold; Region: PAS_4; pfam08448 521674003953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 521674003954 putative active site [active] 521674003955 heme pocket [chemical binding]; other site 521674003956 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 521674003957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674003958 Proline dehydrogenase; Region: Pro_dh; cl03282 521674003959 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 521674003960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521674003961 Glutamate binding site [chemical binding]; other site 521674003962 NAD binding site [chemical binding]; other site 521674003963 catalytic residues [active] 521674003964 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 521674003965 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 521674003966 active site 521674003967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 521674003968 active site 521674003969 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521674003970 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 521674003971 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674003972 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674003973 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674003974 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674003975 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 521674003976 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 521674003977 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 521674003978 putative NADP binding site [chemical binding]; other site 521674003979 active site 521674003980 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521674003981 active site 1 [active] 521674003982 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 521674003983 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 521674003984 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 521674003985 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 521674003986 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 521674003987 putative NAD(P) binding site [chemical binding]; other site 521674003988 active site 521674003989 GH3 auxin-responsive promoter; Region: GH3; pfam03321 521674003990 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521674003991 inhibitor site; inhibition site 521674003992 active site 521674003993 dimer interface [polypeptide binding]; other site 521674003994 catalytic residue [active] 521674003995 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 521674003996 intracellular protease, PfpI family; Region: PfpI; TIGR01382 521674003997 conserved cys residue [active] 521674003998 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 521674003999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674004000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674004001 homodimer interface [polypeptide binding]; other site 521674004002 catalytic residue [active] 521674004003 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 521674004004 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 521674004005 ligand binding site [chemical binding]; other site 521674004006 NAD binding site [chemical binding]; other site 521674004007 catalytic site [active] 521674004008 Protein of unknown function, DUF481; Region: DUF481; pfam04338 521674004009 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674004010 ScpA/B protein; Region: ScpA_ScpB; cl00598 521674004011 Short C-terminal domain; Region: SHOCT; pfam09851 521674004012 Tic20-like protein; Region: Tic20; pfam09685 521674004013 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521674004014 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521674004015 ATP binding site [chemical binding]; other site 521674004016 Mg++ binding site [ion binding]; other site 521674004017 motif III; other site 521674004018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674004019 nucleotide binding region [chemical binding]; other site 521674004020 ATP-binding site [chemical binding]; other site 521674004021 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 521674004022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674004023 active site 521674004024 PAS domain S-box; Region: sensory_box; TIGR00229 521674004025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004026 putative active site [active] 521674004027 heme pocket [chemical binding]; other site 521674004028 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521674004029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004030 putative active site [active] 521674004031 heme pocket [chemical binding]; other site 521674004032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674004033 dimer interface [polypeptide binding]; other site 521674004034 phosphorylation site [posttranslational modification] 521674004035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004036 ATP binding site [chemical binding]; other site 521674004037 Mg2+ binding site [ion binding]; other site 521674004038 G-X-G motif; other site 521674004039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674004040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004041 active site 521674004042 phosphorylation site [posttranslational modification] 521674004043 intermolecular recognition site; other site 521674004044 dimerization interface [polypeptide binding]; other site 521674004045 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674004046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004047 Walker A motif; other site 521674004048 ATP binding site [chemical binding]; other site 521674004049 Walker B motif; other site 521674004050 arginine finger; other site 521674004051 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674004052 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674004053 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674004054 metal ion-dependent adhesion site (MIDAS); other site 521674004055 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 521674004056 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521674004057 ligand binding site; other site 521674004058 oligomer interface; other site 521674004059 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521674004060 dimer interface [polypeptide binding]; other site 521674004061 N-terminal domain interface [polypeptide binding]; other site 521674004062 sulfate 1 binding site; other site 521674004063 Flagellar protein FliS; Region: FliS; cl00654 521674004064 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 521674004065 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521674004066 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521674004067 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521674004068 dimer interface [polypeptide binding]; other site 521674004069 active site 521674004070 PhoD-like phosphatase; Region: PhoD; pfam09423 521674004071 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 521674004072 putative active site [active] 521674004073 putative metal binding site [ion binding]; other site 521674004074 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 521674004075 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 521674004076 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521674004077 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674004078 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 521674004079 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674004080 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521674004081 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674004082 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 521674004083 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 521674004084 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 521674004085 Tetramer interface [polypeptide binding]; other site 521674004086 active site 521674004087 FMN-binding site [chemical binding]; other site 521674004088 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 521674004089 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 521674004090 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 521674004091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 521674004092 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674004093 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674004094 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 521674004095 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521674004096 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521674004097 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521674004098 G1 box; other site 521674004099 G1 box; other site 521674004100 GTP/Mg2+ binding site [chemical binding]; other site 521674004101 GTP/Mg2+ binding site [chemical binding]; other site 521674004102 Switch I region; other site 521674004103 G2 box; other site 521674004104 Switch II region; other site 521674004105 G3 box; other site 521674004106 G4 box; other site 521674004107 G5 box; other site 521674004108 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 521674004109 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 521674004110 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 521674004111 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 521674004112 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 521674004113 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674004114 active site 521674004115 metal binding site [ion binding]; metal-binding site 521674004116 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 521674004117 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 521674004118 HflX GTPase family; Region: HflX; cd01878 521674004119 G1 box; other site 521674004120 GTP/Mg2+ binding site [chemical binding]; other site 521674004121 Switch I region; other site 521674004122 G2 box; other site 521674004123 G3 box; other site 521674004124 Switch II region; other site 521674004125 G4 box; other site 521674004126 G5 box; other site 521674004127 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 521674004128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674004129 motif II; other site 521674004130 CTP synthetase; Validated; Region: pyrG; PRK05380 521674004131 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521674004132 Catalytic site [active] 521674004133 active site 521674004134 UTP binding site [chemical binding]; other site 521674004135 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521674004136 active site 521674004137 putative oxyanion hole; other site 521674004138 catalytic triad [active] 521674004139 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 521674004140 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 521674004141 Ligand binding site; other site 521674004142 oligomer interface; other site 521674004143 PAS fold; Region: PAS_4; pfam08448 521674004144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004145 putative active site [active] 521674004146 heme pocket [chemical binding]; other site 521674004147 PAS domain S-box; Region: sensory_box; TIGR00229 521674004148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004149 putative active site [active] 521674004150 heme pocket [chemical binding]; other site 521674004151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004152 PAS domain; Region: PAS_9; pfam13426 521674004153 putative active site [active] 521674004154 heme pocket [chemical binding]; other site 521674004155 PAS domain S-box; Region: sensory_box; TIGR00229 521674004156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004157 putative active site [active] 521674004158 heme pocket [chemical binding]; other site 521674004159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674004160 dimer interface [polypeptide binding]; other site 521674004161 phosphorylation site [posttranslational modification] 521674004162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004163 ATP binding site [chemical binding]; other site 521674004164 Mg2+ binding site [ion binding]; other site 521674004165 G-X-G motif; other site 521674004166 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 521674004167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004168 active site 521674004169 phosphorylation site [posttranslational modification] 521674004170 intermolecular recognition site; other site 521674004171 dimerization interface [polypeptide binding]; other site 521674004172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521674004173 DNA binding residues [nucleotide binding] 521674004174 dimerization interface [polypeptide binding]; other site 521674004175 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521674004176 Eukaryotic phosphomannomutase; Region: PMM; cl17107 521674004177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674004178 motif II; other site 521674004179 serine racemase; Region: PLN02970 521674004180 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 521674004181 tetramer interface [polypeptide binding]; other site 521674004182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674004183 catalytic residue [active] 521674004184 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 521674004185 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674004186 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674004187 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 521674004188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674004189 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674004190 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 521674004191 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 521674004192 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674004193 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674004194 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674004195 Sulfatase; Region: Sulfatase; cl17466 521674004196 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674004197 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674004198 structural tetrad; other site 521674004199 hypothetical protein; Provisional; Region: PRK08609 521674004200 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 521674004201 active site 521674004202 primer binding site [nucleotide binding]; other site 521674004203 NTP binding site [chemical binding]; other site 521674004204 metal binding triad [ion binding]; metal-binding site 521674004205 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 521674004206 active site 521674004207 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 521674004208 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521674004209 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 521674004210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004211 Walker A motif; other site 521674004212 ATP binding site [chemical binding]; other site 521674004213 Walker B motif; other site 521674004214 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521674004215 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674004216 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674004217 phosphopeptide binding site; other site 521674004218 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 521674004219 SnoaL-like domain; Region: SnoaL_3; pfam13474 521674004220 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase-like protein; Provisional; Region: PRK13277 521674004221 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674004222 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 521674004223 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674004224 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674004225 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674004226 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 521674004227 ThiC family; Region: ThiC; pfam01964 521674004228 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521674004229 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521674004230 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 521674004231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674004232 catalytic residue [active] 521674004233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674004234 dimer interface [polypeptide binding]; other site 521674004235 phosphorylation site [posttranslational modification] 521674004236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004237 ATP binding site [chemical binding]; other site 521674004238 Mg2+ binding site [ion binding]; other site 521674004239 G-X-G motif; other site 521674004240 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 521674004241 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521674004242 dimer interface [polypeptide binding]; other site 521674004243 NAD(P) binding site [chemical binding]; other site 521674004244 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521674004245 substrate binding site [chemical binding]; other site 521674004246 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 521674004247 intersubunit interface [polypeptide binding]; other site 521674004248 active site 521674004249 Zn2+ binding site [ion binding]; other site 521674004250 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 521674004251 Hexamer/Pentamer interface [polypeptide binding]; other site 521674004252 central pore; other site 521674004253 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 521674004254 Hexamer/Pentamer interface [polypeptide binding]; other site 521674004255 central pore; other site 521674004256 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 521674004257 putative catalytic cysteine [active] 521674004258 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 521674004259 Hexamer/Pentamer interface [polypeptide binding]; other site 521674004260 central pore; other site 521674004261 Acetokinase family; Region: Acetate_kinase; cl17229 521674004262 propionate/acetate kinase; Provisional; Region: PRK12379 521674004263 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 521674004264 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 521674004265 Hexamer interface [polypeptide binding]; other site 521674004266 Hexagonal pore residue; other site 521674004267 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 521674004268 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 521674004269 Hexamer interface [polypeptide binding]; other site 521674004270 Hexagonal pore residue; other site 521674004271 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 521674004272 Propanediol utilisation protein PduL; Region: PduL; pfam06130 521674004273 Propanediol utilisation protein PduL; Region: PduL; pfam06130 521674004274 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521674004275 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 521674004276 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521674004277 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 521674004278 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 521674004279 active site 521674004280 substrate binding site [chemical binding]; other site 521674004281 cosubstrate binding site; other site 521674004282 catalytic site [active] 521674004283 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674004284 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 521674004285 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521674004286 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521674004287 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521674004288 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521674004289 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521674004290 active site 521674004291 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674004292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674004293 dimerization interface [polypeptide binding]; other site 521674004294 putative DNA binding site [nucleotide binding]; other site 521674004295 putative Zn2+ binding site [ion binding]; other site 521674004296 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 521674004297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674004298 FeS/SAM binding site; other site 521674004299 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 521674004300 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 521674004301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674004302 binding surface 521674004303 TPR motif; other site 521674004304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674004305 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 521674004306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674004307 binding surface 521674004308 TPR motif; other site 521674004309 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 521674004310 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674004311 active site 521674004312 nucleotide binding site [chemical binding]; other site 521674004313 HIGH motif; other site 521674004314 KMSKS motif; other site 521674004315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674004316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674004317 putative substrate translocation pore; other site 521674004318 diaminopimelate decarboxylase; Region: lysA; TIGR01048 521674004319 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 521674004320 active site 521674004321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521674004322 substrate binding site [chemical binding]; other site 521674004323 catalytic residues [active] 521674004324 dimer interface [polypeptide binding]; other site 521674004325 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 521674004326 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521674004327 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 521674004328 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 521674004329 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 521674004330 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 521674004331 HSP90 family protein; Provisional; Region: PRK14083 521674004332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004333 ATP binding site [chemical binding]; other site 521674004334 Mg2+ binding site [ion binding]; other site 521674004335 G-X-G motif; other site 521674004336 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 521674004337 Zn binding site [ion binding]; other site 521674004338 ethanolamine permease; Region: 2A0305; TIGR00908 521674004339 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 521674004340 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 521674004341 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 521674004342 Family description; Region: VCBS; pfam13517 521674004343 malate dehydrogenase; Provisional; Region: PRK13529 521674004344 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521674004345 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 521674004346 NAD(P) binding site [chemical binding]; other site 521674004347 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521674004348 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521674004349 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521674004350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521674004351 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674004352 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674004353 active site 521674004354 metal binding site [ion binding]; metal-binding site 521674004355 NHL repeat; Region: NHL; pfam01436 521674004356 NHL repeat; Region: NHL; pfam01436 521674004357 NHL repeat; Region: NHL; pfam01436 521674004358 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 521674004359 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521674004360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674004361 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 521674004362 putative ADP-binding pocket [chemical binding]; other site 521674004363 cell division protein MraZ; Reviewed; Region: PRK00326 521674004364 MraZ protein; Region: MraZ; pfam02381 521674004365 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674004366 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674004367 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674004368 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674004369 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 521674004370 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 521674004371 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674004372 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 521674004373 heat shock protein 90; Provisional; Region: PRK05218 521674004374 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 521674004375 ATP binding site [chemical binding]; other site 521674004376 Mg2+ binding site [ion binding]; other site 521674004377 G-X-G motif; other site 521674004378 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674004379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004380 Walker A motif; other site 521674004381 ATP binding site [chemical binding]; other site 521674004382 Walker B motif; other site 521674004383 arginine finger; other site 521674004384 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674004385 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674004386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674004387 metal ion-dependent adhesion site (MIDAS); other site 521674004388 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 521674004389 CARDB; Region: CARDB; pfam07705 521674004390 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674004391 metal ion-dependent adhesion site (MIDAS); other site 521674004392 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674004393 MG2 domain; Region: A2M_N; pfam01835 521674004394 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 521674004395 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674004396 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674004397 protein binding site [polypeptide binding]; other site 521674004398 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674004399 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674004400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674004401 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674004402 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674004403 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 521674004404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674004405 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674004406 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 521674004407 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674004408 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521674004409 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674004410 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521674004411 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 521674004412 ATP binding site [chemical binding]; other site 521674004413 Walker A motif; other site 521674004414 hexamer interface [polypeptide binding]; other site 521674004415 Walker B motif; other site 521674004416 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 521674004417 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521674004418 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521674004419 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 521674004420 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 521674004421 active site 521674004422 dimerization interface [polypeptide binding]; other site 521674004423 Bacitracin resistance protein BacA; Region: BacA; pfam02673 521674004424 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674004425 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674004426 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674004427 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cl00379 521674004428 prephenate dehydrogenase; Validated; Region: PRK08507 521674004429 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 521674004430 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 521674004431 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 521674004432 dimerization interface [polypeptide binding]; other site 521674004433 ATP binding site [chemical binding]; other site 521674004434 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 521674004435 dimerization interface [polypeptide binding]; other site 521674004436 ATP binding site [chemical binding]; other site 521674004437 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 521674004438 MOFRL family; Region: MOFRL; pfam05161 521674004439 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521674004440 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521674004441 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521674004442 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 521674004443 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674004444 Zn2+ binding site [ion binding]; other site 521674004445 Mg2+ binding site [ion binding]; other site 521674004446 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 521674004447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004448 ATP binding site [chemical binding]; other site 521674004449 Mg2+ binding site [ion binding]; other site 521674004450 G-X-G motif; other site 521674004451 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 521674004452 ATP binding site [chemical binding]; other site 521674004453 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 521674004454 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 521674004455 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 521674004456 active site 521674004457 catalytic residue [active] 521674004458 dimer interface [polypeptide binding]; other site 521674004459 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 521674004460 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 521674004461 shikimate binding site; other site 521674004462 NAD(P) binding site [chemical binding]; other site 521674004463 shikimate kinase; Reviewed; Region: aroK; PRK00131 521674004464 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521674004465 ADP binding site [chemical binding]; other site 521674004466 magnesium binding site [ion binding]; other site 521674004467 putative shikimate binding site; other site 521674004468 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 521674004469 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 521674004470 Cupin-like domain; Region: Cupin_8; pfam13621 521674004471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 521674004472 Ycf46; Provisional; Region: ycf46; CHL00195 521674004473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004474 Walker A motif; other site 521674004475 ATP binding site [chemical binding]; other site 521674004476 Walker B motif; other site 521674004477 arginine finger; other site 521674004478 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674004479 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674004480 phosphopeptide binding site; other site 521674004481 Nif-specific regulatory protein; Region: nifA; TIGR01817 521674004482 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 521674004483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004484 Walker A motif; other site 521674004485 ATP binding site [chemical binding]; other site 521674004486 Walker B motif; other site 521674004487 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674004488 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674004489 PQQ-like domain; Region: PQQ_2; pfam13360 521674004490 Trp docking motif [polypeptide binding]; other site 521674004491 active site 521674004492 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 521674004493 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033 521674004494 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 521674004495 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 521674004496 cobalamin binding residues [chemical binding]; other site 521674004497 putative BtuC binding residues; other site 521674004498 dimer interface [polypeptide binding]; other site 521674004499 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 521674004500 Ligand Binding Site [chemical binding]; other site 521674004501 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674004502 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 521674004503 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 521674004504 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 521674004505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674004506 TPR motif; other site 521674004507 binding surface 521674004508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674004509 TPR motif; other site 521674004510 binding surface 521674004511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004512 Walker A motif; other site 521674004513 ATP binding site [chemical binding]; other site 521674004514 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 521674004515 iron-sulfur cluster [ion binding]; other site 521674004516 [2Fe-2S] cluster binding site [ion binding]; other site 521674004517 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 521674004518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 521674004519 putative acyl-acceptor binding pocket; other site 521674004520 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674004521 Trp docking motif [polypeptide binding]; other site 521674004522 active site 521674004523 PQQ-like domain; Region: PQQ_2; pfam13360 521674004524 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 521674004525 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521674004526 active site 521674004527 NTP binding site [chemical binding]; other site 521674004528 metal binding triad [ion binding]; metal-binding site 521674004529 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521674004530 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 521674004531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674004532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674004533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674004534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 521674004535 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 521674004536 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521674004537 NAD(P) binding site [chemical binding]; other site 521674004538 catalytic residues [active] 521674004539 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 521674004540 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 521674004541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521674004542 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 521674004543 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 521674004544 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 521674004545 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 521674004546 Ligand Binding Site [chemical binding]; other site 521674004547 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 521674004548 GAF domain; Region: GAF_3; pfam13492 521674004549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674004550 dimer interface [polypeptide binding]; other site 521674004551 phosphorylation site [posttranslational modification] 521674004552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004553 ATP binding site [chemical binding]; other site 521674004554 Mg2+ binding site [ion binding]; other site 521674004555 G-X-G motif; other site 521674004556 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 521674004557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004558 active site 521674004559 phosphorylation site [posttranslational modification] 521674004560 intermolecular recognition site; other site 521674004561 dimerization interface [polypeptide binding]; other site 521674004562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521674004563 DNA binding site [nucleotide binding] 521674004564 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 521674004565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674004566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674004567 DNA binding residues [nucleotide binding] 521674004568 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 521674004569 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674004570 Sulfatase; Region: Sulfatase; pfam00884 521674004571 YHYH protein; Region: YHYH; pfam14240 521674004572 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 521674004573 substrate binding site [chemical binding]; other site 521674004574 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674004575 Sulfatase; Region: Sulfatase; pfam00884 521674004576 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 521674004577 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 521674004578 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 521674004579 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 521674004580 active site 521674004581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 521674004582 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 521674004583 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 521674004584 ferrous iron transporter FeoB; Region: feoB; TIGR00437 521674004585 G1 box; other site 521674004586 GTP/Mg2+ binding site [chemical binding]; other site 521674004587 G2 box; other site 521674004588 G3 box; other site 521674004589 Switch II region; other site 521674004590 G4 box; other site 521674004591 G5 box; other site 521674004592 Nucleoside recognition; Region: Gate; pfam07670 521674004593 Nucleoside recognition; Region: Gate; pfam07670 521674004594 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674004595 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674004596 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674004597 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674004598 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674004599 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674004600 BON domain; Region: BON; pfam04972 521674004601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674004602 dimerization interface [polypeptide binding]; other site 521674004603 putative DNA binding site [nucleotide binding]; other site 521674004604 putative Zn2+ binding site [ion binding]; other site 521674004605 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 521674004606 amphipathic channel; other site 521674004607 Asn-Pro-Ala signature motifs; other site 521674004608 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521674004609 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521674004610 active site 521674004611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 521674004612 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 521674004613 elongation factor P; Validated; Region: PRK00529 521674004614 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521674004615 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521674004616 RNA binding site [nucleotide binding]; other site 521674004617 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521674004618 RNA binding site [nucleotide binding]; other site 521674004619 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521674004620 active site residue [active] 521674004621 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 521674004622 putative ADP-ribose binding site [chemical binding]; other site 521674004623 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 521674004624 catalytic Zn binding site [ion binding]; other site 521674004625 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 521674004626 structural Zn binding site [ion binding]; other site 521674004627 tetramer interface [polypeptide binding]; other site 521674004628 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 521674004629 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 521674004630 Active site cavity [active] 521674004631 catalytic acid [active] 521674004632 ferrochelatase; Reviewed; Region: hemH; PRK00035 521674004633 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 521674004634 C-terminal domain interface [polypeptide binding]; other site 521674004635 active site 521674004636 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 521674004637 active site 521674004638 N-terminal domain interface [polypeptide binding]; other site 521674004639 chemotaxis protein CheA; Provisional; Region: PRK10547 521674004640 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521674004641 putative binding surface; other site 521674004642 active site 521674004643 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521674004644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674004645 ATP binding site [chemical binding]; other site 521674004646 Mg2+ binding site [ion binding]; other site 521674004647 G-X-G motif; other site 521674004648 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 521674004649 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 521674004650 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674004651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004652 active site 521674004653 phosphorylation site [posttranslational modification] 521674004654 intermolecular recognition site; other site 521674004655 dimerization interface [polypeptide binding]; other site 521674004656 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 521674004657 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674004658 GAF domain; Region: GAF; pfam01590 521674004659 PAS domain S-box; Region: sensory_box; TIGR00229 521674004660 PAS domain; Region: PAS_10; pfam13596 521674004661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521674004662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521674004663 dimer interface [polypeptide binding]; other site 521674004664 putative CheW interface [polypeptide binding]; other site 521674004665 Response regulator receiver domain; Region: Response_reg; pfam00072 521674004666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004667 active site 521674004668 phosphorylation site [posttranslational modification] 521674004669 intermolecular recognition site; other site 521674004670 dimerization interface [polypeptide binding]; other site 521674004671 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 521674004672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004673 active site 521674004674 phosphorylation site [posttranslational modification] 521674004675 intermolecular recognition site; other site 521674004676 dimerization interface [polypeptide binding]; other site 521674004677 CheB methylesterase; Region: CheB_methylest; pfam01339 521674004678 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 521674004679 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521674004680 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521674004681 PAS fold; Region: PAS; pfam00989 521674004682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674004683 putative active site [active] 521674004684 heme pocket [chemical binding]; other site 521674004685 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674004686 GAF domain; Region: GAF; pfam01590 521674004687 Response regulator receiver domain; Region: Response_reg; pfam00072 521674004688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004689 active site 521674004690 phosphorylation site [posttranslational modification] 521674004691 intermolecular recognition site; other site 521674004692 dimerization interface [polypeptide binding]; other site 521674004693 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 521674004694 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674004695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674004696 active site 521674004697 phosphorylation site [posttranslational modification] 521674004698 intermolecular recognition site; other site 521674004699 dimerization interface [polypeptide binding]; other site 521674004700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674004701 Walker A motif; other site 521674004702 ATP binding site [chemical binding]; other site 521674004703 Walker B motif; other site 521674004704 arginine finger; other site 521674004705 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674004706 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 521674004707 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674004708 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521674004709 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674004710 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521674004711 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 521674004712 ATP binding site [chemical binding]; other site 521674004713 Walker A motif; other site 521674004714 hexamer interface [polypeptide binding]; other site 521674004715 Walker B motif; other site 521674004716 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 521674004717 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 521674004718 active site 521674004719 catalytic site [active] 521674004720 homodimer interface [polypeptide binding]; other site 521674004721 Lid 1; other site 521674004722 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 521674004723 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 521674004724 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 521674004725 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 521674004726 GTP binding site; other site 521674004727 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 521674004728 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 521674004729 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521674004730 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674004731 Protein of unknown function, DUF606; Region: DUF606; pfam04657 521674004732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674004733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674004734 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 521674004735 dihydropteroate synthase; Region: DHPS; TIGR01496 521674004736 substrate binding pocket [chemical binding]; other site 521674004737 dimer interface [polypeptide binding]; other site 521674004738 inhibitor binding site; inhibition site 521674004739 biotin synthase; Validated; Region: PRK06256 521674004740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674004741 FeS/SAM binding site; other site 521674004742 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 521674004743 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674004744 Trp docking motif [polypeptide binding]; other site 521674004745 active site 521674004746 PQQ-like domain; Region: PQQ_2; pfam13360 521674004747 Flagellin N-methylase; Region: FliB; cl00497 521674004748 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 521674004749 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674004750 Walker A motif; other site 521674004751 ATP binding site [chemical binding]; other site 521674004752 Walker B motif; other site 521674004753 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521674004754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674004755 S-adenosylmethionine binding site [chemical binding]; other site 521674004756 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 521674004757 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521674004758 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 521674004759 homodimer interface [polypeptide binding]; other site 521674004760 substrate-cofactor binding pocket; other site 521674004761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674004762 catalytic residue [active] 521674004763 argininosuccinate lyase; Provisional; Region: PRK00855 521674004764 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 521674004765 active sites [active] 521674004766 tetramer interface [polypeptide binding]; other site 521674004767 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 521674004768 Ligand Binding Site [chemical binding]; other site 521674004769 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 521674004770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674004771 FeS/SAM binding site; other site 521674004772 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521674004773 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 521674004774 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 521674004775 Maf-like protein; Region: Maf; pfam02545 521674004776 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 521674004777 active site 521674004778 dimer interface [polypeptide binding]; other site 521674004779 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 521674004780 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 521674004781 active site 521674004782 Zn binding site [ion binding]; other site 521674004783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674004784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674004785 putative substrate translocation pore; other site 521674004786 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674004787 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521674004788 sugar binding site [chemical binding]; other site 521674004789 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674004790 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 521674004791 HEAT repeats; Region: HEAT_2; pfam13646 521674004792 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674004793 Cytochrome c; Region: Cytochrom_C; pfam00034 521674004794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 521674004795 DNA-binding site [nucleotide binding]; DNA binding site 521674004796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521674004797 DNA-binding site [nucleotide binding]; DNA binding site 521674004798 Transcriptional regulators [Transcription]; Region: GntR; COG1802 521674004799 FCD domain; Region: FCD; pfam07729 521674004800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521674004801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521674004802 active site 521674004803 catalytic tetrad [active] 521674004804 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 521674004805 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674004806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674004807 NAD(P) binding site [chemical binding]; other site 521674004808 active site 521674004809 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674004810 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 521674004811 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 521674004812 putative active site [active] 521674004813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674004814 FtsX-like permease family; Region: FtsX; pfam02687 521674004815 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674004816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674004817 Walker A/P-loop; other site 521674004818 ATP binding site [chemical binding]; other site 521674004819 Q-loop/lid; other site 521674004820 ABC transporter signature motif; other site 521674004821 Walker B; other site 521674004822 D-loop; other site 521674004823 H-loop/switch region; other site 521674004824 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521674004825 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 521674004826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674004827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674004828 active site 521674004829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521674004830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674004831 Coenzyme A binding pocket [chemical binding]; other site 521674004832 ADP-glucose phosphorylase; Region: PLN02643 521674004833 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521674004834 nucleotide binding site/active site [active] 521674004835 HIT family signature motif; other site 521674004836 catalytic residue [active] 521674004837 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674004838 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 521674004839 HEAT repeats; Region: HEAT_2; pfam13646 521674004840 HEAT repeats; Region: HEAT_2; pfam13646 521674004841 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674004842 Global regulator protein family; Region: CsrA; pfam02599 521674004843 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 521674004844 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521674004845 ligand binding site; other site 521674004846 oligomer interface; other site 521674004847 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521674004848 dimer interface [polypeptide binding]; other site 521674004849 N-terminal domain interface [polypeptide binding]; other site 521674004850 sulfate 1 binding site; other site 521674004851 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674004852 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 521674004853 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674004854 Trp docking motif [polypeptide binding]; other site 521674004855 active site 521674004856 PQQ-like domain; Region: PQQ_2; pfam13360 521674004857 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 521674004858 putative ligand binding site [chemical binding]; other site 521674004859 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 521674004860 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 521674004861 active site 521674004862 FMN binding site [chemical binding]; other site 521674004863 substrate binding site [chemical binding]; other site 521674004864 putative catalytic residue [active] 521674004865 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 521674004866 MPT binding site; other site 521674004867 trimer interface [polypeptide binding]; other site 521674004868 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 521674004869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674004870 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 521674004871 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 521674004872 apolar tunnel; other site 521674004873 heme binding site [chemical binding]; other site 521674004874 dimerization interface [polypeptide binding]; other site 521674004875 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521674004876 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 521674004877 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521674004878 G1 box; other site 521674004879 GTP/Mg2+ binding site [chemical binding]; other site 521674004880 Switch I region; other site 521674004881 G2 box; other site 521674004882 Switch II region; other site 521674004883 G3 box; other site 521674004884 G4 box; other site 521674004885 G5 box; other site 521674004886 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 521674004887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521674004888 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521674004889 ABC-ATPase subunit interface; other site 521674004890 dimer interface [polypeptide binding]; other site 521674004891 putative PBP binding regions; other site 521674004892 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 521674004893 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521674004894 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521674004895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521674004896 ABC-ATPase subunit interface; other site 521674004897 dimer interface [polypeptide binding]; other site 521674004898 putative PBP binding regions; other site 521674004899 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521674004900 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521674004901 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 521674004902 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 521674004903 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 521674004904 intersubunit interface [polypeptide binding]; other site 521674004905 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 521674004906 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 521674004907 FMN binding site [chemical binding]; other site 521674004908 dimer interface [polypeptide binding]; other site 521674004909 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521674004910 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 521674004911 putative substrate binding site [chemical binding]; other site 521674004912 putative ATP binding site [chemical binding]; other site 521674004913 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 521674004914 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 521674004915 trigger factor; Region: tig; TIGR00115 521674004916 glycerol kinase; Provisional; Region: glpK; PRK00047 521674004917 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 521674004918 N- and C-terminal domain interface [polypeptide binding]; other site 521674004919 active site 521674004920 MgATP binding site [chemical binding]; other site 521674004921 catalytic site [active] 521674004922 metal binding site [ion binding]; metal-binding site 521674004923 glycerol binding site [chemical binding]; other site 521674004924 homotetramer interface [polypeptide binding]; other site 521674004925 homodimer interface [polypeptide binding]; other site 521674004926 FBP binding site [chemical binding]; other site 521674004927 protein IIAGlc interface [polypeptide binding]; other site 521674004928 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 521674004929 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674004930 HNH endonuclease; Region: HNH_2; pfam13391 521674004931 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 521674004932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521674004933 Walker A motif; other site 521674004934 ATP binding site [chemical binding]; other site 521674004935 Walker B motif; other site 521674004936 arginine finger; other site 521674004937 LexA regulated protein; Provisional; Region: PRK11675 521674004938 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674004939 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 521674004940 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674004941 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674004942 protein binding site [polypeptide binding]; other site 521674004943 Peptidase family M41; Region: Peptidase_M41; pfam01434 521674004944 ribonuclease Y; Region: RNase_Y; TIGR03319 521674004945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674004946 Zn2+ binding site [ion binding]; other site 521674004947 Mg2+ binding site [ion binding]; other site 521674004948 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521674004949 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521674004950 Ligand Binding Site [chemical binding]; other site 521674004951 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 521674004952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674004953 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 521674004954 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 521674004955 homotrimer interaction site [polypeptide binding]; other site 521674004956 active site 521674004957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674004958 putative DNA binding site [nucleotide binding]; other site 521674004959 dimerization interface [polypeptide binding]; other site 521674004960 putative Zn2+ binding site [ion binding]; other site 521674004961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674004962 Walker A/P-loop; other site 521674004963 ATP binding site [chemical binding]; other site 521674004964 ABC transporter; Region: ABC_tran; pfam00005 521674004965 Q-loop/lid; other site 521674004966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674004967 ABC transporter signature motif; other site 521674004968 ABC transporter signature motif; other site 521674004969 Walker B; other site 521674004970 Walker B; other site 521674004971 D-loop; other site 521674004972 H-loop/switch region; other site 521674004973 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 521674004974 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674004975 Outer membrane efflux protein; Region: OEP; pfam02321 521674004976 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674004977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674004978 catalytic residues [active] 521674004979 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 521674004980 homotrimer interaction site [polypeptide binding]; other site 521674004981 putative active site [active] 521674004982 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 521674004983 active site 521674004984 multimer interface [polypeptide binding]; other site 521674004985 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 521674004986 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 521674004987 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 521674004988 catalytic site [active] 521674004989 subunit interface [polypeptide binding]; other site 521674004990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674004991 dimerization interface [polypeptide binding]; other site 521674004992 putative DNA binding site [nucleotide binding]; other site 521674004993 putative Zn2+ binding site [ion binding]; other site 521674004994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 521674004995 classical (c) SDRs; Region: SDR_c; cd05233 521674004996 NAD(P) binding site [chemical binding]; other site 521674004997 active site 521674004998 dihydropteroate synthase-related protein; Region: TIGR00284 521674004999 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 521674005000 substrate binding pocket [chemical binding]; other site 521674005001 inhibitor binding site; inhibition site 521674005002 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 521674005003 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 521674005004 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 521674005005 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 521674005006 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 521674005007 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 521674005008 glutamine binding [chemical binding]; other site 521674005009 catalytic triad [active] 521674005010 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521674005011 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674005012 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521674005013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674005014 active site 521674005015 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521674005016 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674005017 active site 521674005018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674005019 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521674005020 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674005021 active site 521674005022 transcription termination factor Rho; Provisional; Region: PRK12608 521674005023 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521674005024 RNA binding site [nucleotide binding]; other site 521674005025 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674005026 Walker A motif; other site 521674005027 ATP binding site [chemical binding]; other site 521674005028 Walker B motif; other site 521674005029 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 521674005030 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 521674005031 putative active site [active] 521674005032 putative NTP binding site [chemical binding]; other site 521674005033 putative nucleic acid binding site [nucleotide binding]; other site 521674005034 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521674005035 active site 521674005036 putative substrate binding region [chemical binding]; other site 521674005037 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 521674005038 Clp amino terminal domain; Region: Clp_N; pfam02861 521674005039 Clp amino terminal domain; Region: Clp_N; pfam02861 521674005040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005041 Walker A motif; other site 521674005042 ATP binding site [chemical binding]; other site 521674005043 Walker B motif; other site 521674005044 arginine finger; other site 521674005045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005046 Walker A motif; other site 521674005047 ATP binding site [chemical binding]; other site 521674005048 Walker B motif; other site 521674005049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521674005050 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521674005051 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 521674005052 nucleotide binding site [chemical binding]; other site 521674005053 NEF interaction site [polypeptide binding]; other site 521674005054 SBD interface [polypeptide binding]; other site 521674005055 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 521674005056 Prephenate dehydratase; Region: PDT; pfam00800 521674005057 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 521674005058 putative L-Phe binding site [chemical binding]; other site 521674005059 triosephosphate isomerase; Provisional; Region: PRK14567 521674005060 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521674005061 substrate binding site [chemical binding]; other site 521674005062 dimer interface [polypeptide binding]; other site 521674005063 catalytic triad [active] 521674005064 Preprotein translocase SecG subunit; Region: SecG; pfam03840 521674005065 hypothetical protein; Provisional; Region: PRK11820 521674005066 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 521674005067 Poxvirus DNA-directed RNA polymerase, 35 kD subunit; Region: Pox_RNA_pol_35; pfam03396 521674005068 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 521674005069 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 521674005070 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 521674005071 catalytic site [active] 521674005072 G-X2-G-X-G-K; other site 521674005073 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 521674005074 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 521674005075 Flavoprotein; Region: Flavoprotein; pfam02441 521674005076 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 521674005077 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674005078 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521674005079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521674005080 Mg2+ binding site [ion binding]; other site 521674005081 G-X-G motif; other site 521674005082 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674005083 anti sigma factor interaction site; other site 521674005084 regulatory phosphorylation site [posttranslational modification]; other site 521674005085 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521674005086 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521674005087 active site 521674005088 intersubunit interface [polypeptide binding]; other site 521674005089 catalytic residue [active] 521674005090 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 521674005091 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521674005092 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 521674005093 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 521674005094 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 521674005095 Permease; Region: Permease; pfam02405 521674005096 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 521674005097 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 521674005098 Walker A/P-loop; other site 521674005099 ATP binding site [chemical binding]; other site 521674005100 Q-loop/lid; other site 521674005101 ABC transporter signature motif; other site 521674005102 Walker B; other site 521674005103 D-loop; other site 521674005104 H-loop/switch region; other site 521674005105 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 521674005106 mce related protein; Region: MCE; pfam02470 521674005107 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 521674005108 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521674005109 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674005110 active site 521674005111 HIGH motif; other site 521674005112 nucleotide binding site [chemical binding]; other site 521674005113 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521674005114 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521674005115 active site 521674005116 KMSKS motif; other site 521674005117 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521674005118 tRNA binding surface [nucleotide binding]; other site 521674005119 anticodon binding site; other site 521674005120 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521674005121 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 521674005122 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 521674005123 active site 521674005124 catalytic residues [active] 521674005125 metal binding site [ion binding]; metal-binding site 521674005126 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 521674005127 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 521674005128 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 521674005129 GDP-binding site [chemical binding]; other site 521674005130 ACT binding site; other site 521674005131 IMP binding site; other site 521674005132 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 521674005133 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521674005134 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521674005135 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 521674005136 putative metal binding site [ion binding]; other site 521674005137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521674005138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674005139 non-specific DNA binding site [nucleotide binding]; other site 521674005140 salt bridge; other site 521674005141 sequence-specific DNA binding site [nucleotide binding]; other site 521674005142 Cupin domain; Region: Cupin_2; pfam07883 521674005143 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 521674005144 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521674005145 NAD(P) binding site [chemical binding]; other site 521674005146 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 521674005147 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 521674005148 substrate-cofactor binding pocket; other site 521674005149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674005150 catalytic residue [active] 521674005151 Peptidase M60-like family; Region: M60-like; pfam13402 521674005152 Predicted membrane protein [Function unknown]; Region: COG2860 521674005153 UPF0126 domain; Region: UPF0126; pfam03458 521674005154 UPF0126 domain; Region: UPF0126; pfam03458 521674005155 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 521674005156 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 521674005157 catalytic residues [active] 521674005158 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 521674005159 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 521674005160 putative active site [active] 521674005161 oxyanion strand; other site 521674005162 catalytic triad [active] 521674005163 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 521674005164 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674005165 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674005166 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674005167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674005168 active site 521674005169 phosphorylation site [posttranslational modification] 521674005170 intermolecular recognition site; other site 521674005171 dimerization interface [polypeptide binding]; other site 521674005172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005173 Walker A motif; other site 521674005174 ATP binding site [chemical binding]; other site 521674005175 Walker B motif; other site 521674005176 arginine finger; other site 521674005177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674005178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674005179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521674005180 dimerization interface [polypeptide binding]; other site 521674005181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674005182 phosphorylation site [posttranslational modification] 521674005183 dimer interface [polypeptide binding]; other site 521674005184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674005185 ATP binding site [chemical binding]; other site 521674005186 Mg2+ binding site [ion binding]; other site 521674005187 G-X-G motif; other site 521674005188 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 521674005189 active site 521674005190 FCD domain; Region: FCD; pfam07729 521674005191 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674005192 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674005193 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674005194 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674005195 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674005196 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674005197 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674005198 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 521674005199 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521674005200 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 521674005201 Na binding site [ion binding]; other site 521674005202 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521674005203 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 521674005204 substrate binding site [chemical binding]; other site 521674005205 ATP binding site [chemical binding]; other site 521674005206 D-mannonate oxidoreductase; Provisional; Region: PRK08277 521674005207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674005208 NAD(P) binding site [chemical binding]; other site 521674005209 active site 521674005210 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 521674005211 MraW methylase family; Region: Methyltransf_5; cl17771 521674005212 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 521674005213 putative FMN binding site [chemical binding]; other site 521674005214 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 521674005215 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 521674005216 DNA methylase; Region: N6_N4_Mtase; cl17433 521674005217 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 521674005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005219 S-adenosylmethionine binding site [chemical binding]; other site 521674005220 TIR domain; Region: TIR_2; pfam13676 521674005221 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 521674005222 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 521674005223 active site 521674005224 catalytic triad [active] 521674005225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005226 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521674005227 Walker A motif; other site 521674005228 ATP binding site [chemical binding]; other site 521674005229 Walker B motif; other site 521674005230 arginine finger; other site 521674005231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521674005232 active site 521674005233 Galactosyltransferase; Region: Galactosyl_T; pfam01762 521674005234 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521674005235 major capsid protein; Region: PHA00665 521674005236 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 521674005237 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 521674005238 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 521674005239 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 521674005240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521674005241 DNA-binding site [nucleotide binding]; DNA binding site 521674005242 Global regulator protein family; Region: CsrA; cl00670 521674005243 HD domain; Region: HD_3; cl17350 521674005244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521674005245 active site 521674005246 Int/Topo IB signature motif; other site 521674005247 DNA binding site [nucleotide binding] 521674005248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521674005249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674005250 non-specific DNA binding site [nucleotide binding]; other site 521674005251 salt bridge; other site 521674005252 sequence-specific DNA binding site [nucleotide binding]; other site 521674005253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674005254 non-specific DNA binding site [nucleotide binding]; other site 521674005255 salt bridge; other site 521674005256 sequence-specific DNA binding site [nucleotide binding]; other site 521674005257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521674005258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674005259 non-specific DNA binding site [nucleotide binding]; other site 521674005260 salt bridge; other site 521674005261 sequence-specific DNA binding site [nucleotide binding]; other site 521674005262 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521674005263 metal binding site 2 [ion binding]; metal-binding site 521674005264 putative DNA binding helix; other site 521674005265 metal binding site 1 [ion binding]; metal-binding site 521674005266 dimer interface [polypeptide binding]; other site 521674005267 structural Zn2+ binding site [ion binding]; other site 521674005268 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 521674005269 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 521674005270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674005271 Walker A/P-loop; other site 521674005272 ATP binding site [chemical binding]; other site 521674005273 Q-loop/lid; other site 521674005274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674005275 ABC transporter signature motif; other site 521674005276 Walker B; other site 521674005277 D-loop; other site 521674005278 ABC transporter; Region: ABC_tran_2; pfam12848 521674005279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521674005280 aromatic acid decarboxylase; Validated; Region: PRK05920 521674005281 Flavoprotein; Region: Flavoprotein; pfam02441 521674005282 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 521674005283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005284 S-adenosylmethionine binding site [chemical binding]; other site 521674005285 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 521674005286 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 521674005287 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 521674005288 active site 521674005289 intersubunit interface [polypeptide binding]; other site 521674005290 zinc binding site [ion binding]; other site 521674005291 Na+ binding site [ion binding]; other site 521674005292 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 521674005293 metal binding site [ion binding]; metal-binding site 521674005294 substrate binding pocket [chemical binding]; other site 521674005295 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 521674005296 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 521674005297 tandem repeat interface [polypeptide binding]; other site 521674005298 oligomer interface [polypeptide binding]; other site 521674005299 active site residues [active] 521674005300 Glucuronate isomerase; Region: UxaC; cl00829 521674005301 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674005302 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674005303 phosphopeptide binding site; other site 521674005304 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674005305 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 521674005306 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674005307 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674005308 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521674005309 Putative esterase; Region: Esterase; pfam00756 521674005310 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 521674005311 Strictosidine synthase; Region: Str_synth; pfam03088 521674005312 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674005313 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674005314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674005315 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674005316 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674005317 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674005318 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674005319 elongation factor G; Reviewed; Region: PRK00007 521674005320 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521674005321 G1 box; other site 521674005322 putative GEF interaction site [polypeptide binding]; other site 521674005323 GTP/Mg2+ binding site [chemical binding]; other site 521674005324 Switch I region; other site 521674005325 G2 box; other site 521674005326 G3 box; other site 521674005327 Switch II region; other site 521674005328 G4 box; other site 521674005329 G5 box; other site 521674005330 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 521674005331 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521674005332 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521674005333 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 521674005334 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 521674005335 tetramer interface [polypeptide binding]; other site 521674005336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674005337 catalytic residue [active] 521674005338 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 521674005339 histidinol dehydrogenase; Region: hisD; TIGR00069 521674005340 NAD binding site [chemical binding]; other site 521674005341 dimerization interface [polypeptide binding]; other site 521674005342 product binding site; other site 521674005343 substrate binding site [chemical binding]; other site 521674005344 zinc binding site [ion binding]; other site 521674005345 catalytic residues [active] 521674005346 Beta-lactamase; Region: Beta-lactamase; pfam00144 521674005347 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521674005348 hydroxyglutarate oxidase; Provisional; Region: PRK11728 521674005349 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 521674005350 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 521674005351 putative active site [active] 521674005352 dimerization interface [polypeptide binding]; other site 521674005353 putative tRNAtyr binding site [nucleotide binding]; other site 521674005354 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 521674005355 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 521674005356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674005357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674005358 active site 521674005359 ATP binding site [chemical binding]; other site 521674005360 substrate binding site [chemical binding]; other site 521674005361 activation loop (A-loop); other site 521674005362 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674005363 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674005364 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 521674005365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005366 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521674005367 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 521674005368 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 521674005369 putative RNA binding site [nucleotide binding]; other site 521674005370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005371 S-adenosylmethionine binding site [chemical binding]; other site 521674005372 Response regulator receiver domain; Region: Response_reg; pfam00072 521674005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674005374 active site 521674005375 phosphorylation site [posttranslational modification] 521674005376 intermolecular recognition site; other site 521674005377 dimerization interface [polypeptide binding]; other site 521674005378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674005379 Protein kinase domain; Region: Pkinase; pfam00069 521674005380 active site 521674005381 ATP binding site [chemical binding]; other site 521674005382 substrate binding site [chemical binding]; other site 521674005383 activation loop (A-loop); other site 521674005384 Right handed beta helix region; Region: Beta_helix; pfam13229 521674005385 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674005386 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674005387 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 521674005388 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 521674005389 Ligand Binding Site [chemical binding]; other site 521674005390 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674005391 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674005392 active site 521674005393 ATP binding site [chemical binding]; other site 521674005394 substrate binding site [chemical binding]; other site 521674005395 activation loop (A-loop); other site 521674005396 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 521674005397 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 521674005398 dimer interface [polypeptide binding]; other site 521674005399 active site 521674005400 glycine-pyridoxal phosphate binding site [chemical binding]; other site 521674005401 folate binding site [chemical binding]; other site 521674005402 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521674005403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521674005404 DNA binding residues [nucleotide binding] 521674005405 TPR repeat; Region: TPR_11; pfam13414 521674005406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674005407 binding surface 521674005408 TPR motif; other site 521674005409 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 521674005410 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 521674005411 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 521674005412 active site 521674005413 ribulose/triose binding site [chemical binding]; other site 521674005414 phosphate binding site [ion binding]; other site 521674005415 substrate (anthranilate) binding pocket [chemical binding]; other site 521674005416 product (indole) binding pocket [chemical binding]; other site 521674005417 CAAX protease self-immunity; Region: Abi; pfam02517 521674005418 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521674005419 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521674005420 active site 521674005421 HIGH motif; other site 521674005422 dimer interface [polypeptide binding]; other site 521674005423 KMSKS motif; other site 521674005424 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674005425 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674005426 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674005427 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 521674005428 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 521674005429 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 521674005430 active site 521674005431 metal binding site [ion binding]; metal-binding site 521674005432 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 521674005433 domain I; other site 521674005434 phosphate binding site [ion binding]; other site 521674005435 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521674005436 domain II; other site 521674005437 domain III; other site 521674005438 nucleotide binding site [chemical binding]; other site 521674005439 DNA binding groove [nucleotide binding] 521674005440 catalytic site [active] 521674005441 domain IV; other site 521674005442 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 521674005443 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 521674005444 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 521674005445 SurA N-terminal domain; Region: SurA_N_3; cl07813 521674005446 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521674005447 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521674005448 Walker A/P-loop; other site 521674005449 ATP binding site [chemical binding]; other site 521674005450 Q-loop/lid; other site 521674005451 ABC transporter signature motif; other site 521674005452 Walker B; other site 521674005453 D-loop; other site 521674005454 H-loop/switch region; other site 521674005455 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 521674005456 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 521674005457 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 521674005458 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 521674005459 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 521674005460 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 521674005461 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521674005462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674005463 FeS/SAM binding site; other site 521674005464 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674005465 anti sigma factor interaction site; other site 521674005466 regulatory phosphorylation site [posttranslational modification]; other site 521674005467 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 521674005468 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521674005469 TMP-binding site; other site 521674005470 ATP-binding site [chemical binding]; other site 521674005471 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674005472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674005473 phosphopeptide binding site; other site 521674005474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674005475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674005476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 521674005477 purine nucleoside phosphorylase; Provisional; Region: PRK08202 521674005478 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 521674005479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674005480 NAD(P) binding site [chemical binding]; other site 521674005481 active site 521674005482 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 521674005483 Bifunctional nuclease; Region: DNase-RNase; pfam02577 521674005484 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 521674005485 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 521674005486 dimer interface [polypeptide binding]; other site 521674005487 active site 521674005488 CoA binding pocket [chemical binding]; other site 521674005489 S-adenosylmethionine synthetase; Validated; Region: PRK05250 521674005490 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521674005491 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521674005492 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521674005493 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 521674005494 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 521674005495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521674005496 Walker A/P-loop; other site 521674005497 ATP binding site [chemical binding]; other site 521674005498 Q-loop/lid; other site 521674005499 ABC transporter signature motif; other site 521674005500 Walker B; other site 521674005501 D-loop; other site 521674005502 H-loop/switch region; other site 521674005503 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 521674005504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521674005505 Walker A/P-loop; other site 521674005506 ATP binding site [chemical binding]; other site 521674005507 Q-loop/lid; other site 521674005508 ABC transporter signature motif; other site 521674005509 Walker B; other site 521674005510 D-loop; other site 521674005511 H-loop/switch region; other site 521674005512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521674005513 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 521674005514 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521674005515 RNA binding site [nucleotide binding]; other site 521674005516 active site 521674005517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521674005518 glycogen branching enzyme; Provisional; Region: PRK12313 521674005519 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 521674005520 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 521674005521 active site 521674005522 catalytic site [active] 521674005523 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 521674005524 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674005525 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 521674005526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005527 Walker A motif; other site 521674005528 ATP binding site [chemical binding]; other site 521674005529 Walker B motif; other site 521674005530 arginine finger; other site 521674005531 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 521674005532 PhoH-like protein; Region: PhoH; pfam02562 521674005533 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 521674005534 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 521674005535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674005536 Zn2+ binding site [ion binding]; other site 521674005537 Mg2+ binding site [ion binding]; other site 521674005538 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 521674005539 FOG: CBS domain [General function prediction only]; Region: COG0517 521674005540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521674005541 Transporter associated domain; Region: CorC_HlyC; smart01091 521674005542 Predicted permease; Region: DUF318; cl17795 521674005543 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674005544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674005545 Walker A motif; other site 521674005546 ATP binding site [chemical binding]; other site 521674005547 Walker B motif; other site 521674005548 arginine finger; other site 521674005549 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 521674005550 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 521674005551 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674005552 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674005553 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521674005554 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 521674005555 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 521674005556 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 521674005557 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521674005558 FeoA domain; Region: FeoA; pfam04023 521674005559 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674005560 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674005561 catalytic residues [active] 521674005562 LexA repressor; Validated; Region: PRK00215 521674005563 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 521674005564 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521674005565 Catalytic site [active] 521674005566 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 521674005567 catalytic residues [active] 521674005568 substrate binding pocket [chemical binding]; other site 521674005569 substrate-Mg2+ binding site; other site 521674005570 aspartate-rich region 1; other site 521674005571 aspartate-rich region 2; other site 521674005572 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 521674005573 active site lid residues [active] 521674005574 substrate binding pocket [chemical binding]; other site 521674005575 catalytic residues [active] 521674005576 substrate-Mg2+ binding site; other site 521674005577 aspartate-rich region 1; other site 521674005578 aspartate-rich region 2; other site 521674005579 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 521674005580 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521674005581 G1 box; other site 521674005582 GTP/Mg2+ binding site [chemical binding]; other site 521674005583 G2 box; other site 521674005584 Switch I region; other site 521674005585 G3 box; other site 521674005586 Switch II region; other site 521674005587 G4 box; other site 521674005588 G5 box; other site 521674005589 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521674005590 G1 box; other site 521674005591 GTP/Mg2+ binding site [chemical binding]; other site 521674005592 Switch I region; other site 521674005593 G2 box; other site 521674005594 G3 box; other site 521674005595 Switch II region; other site 521674005596 G4 box; other site 521674005597 G5 box; other site 521674005598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005599 S-adenosylmethionine binding site [chemical binding]; other site 521674005600 short chain dehydrogenase; Provisional; Region: PRK05650 521674005601 classical (c) SDRs; Region: SDR_c; cd05233 521674005602 NAD(P) binding site [chemical binding]; other site 521674005603 active site 521674005604 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 521674005605 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 521674005606 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674005607 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 521674005608 Amidohydrolase; Region: Amidohydro_2; pfam04909 521674005609 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521674005610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674005611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674005612 DNA binding residues [nucleotide binding] 521674005613 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 521674005614 pantoate--beta-alanine ligase; Region: panC; TIGR00018 521674005615 Pantoate-beta-alanine ligase; Region: PanC; cd00560 521674005616 active site 521674005617 ATP-binding site [chemical binding]; other site 521674005618 pantoate-binding site; other site 521674005619 HXXH motif; other site 521674005620 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 521674005621 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674005622 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 521674005623 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 521674005624 active site 521674005625 substrate-binding site [chemical binding]; other site 521674005626 metal-binding site [ion binding] 521674005627 ATP binding site [chemical binding]; other site 521674005628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 521674005629 Cytochrome P450; Region: p450; cl12078 521674005630 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 521674005631 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521674005632 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 521674005633 B3/4 domain; Region: B3_4; pfam03483 521674005634 tRNA synthetase B5 domain; Region: B5; smart00874 521674005635 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521674005636 dimer interface [polypeptide binding]; other site 521674005637 motif 1; other site 521674005638 motif 3; other site 521674005639 motif 2; other site 521674005640 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 521674005641 Response regulator receiver domain; Region: Response_reg; pfam00072 521674005642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674005643 active site 521674005644 phosphorylation site [posttranslational modification] 521674005645 intermolecular recognition site; other site 521674005646 dimerization interface [polypeptide binding]; other site 521674005647 FHA domain; Region: FHA; pfam00498 521674005648 phosphopeptide binding site; other site 521674005649 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 521674005650 cyclase homology domain; Region: CHD; cd07302 521674005651 nucleotidyl binding site; other site 521674005652 metal binding site [ion binding]; metal-binding site 521674005653 dimer interface [polypeptide binding]; other site 521674005654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674005655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674005656 active site 521674005657 ATP binding site [chemical binding]; other site 521674005658 substrate binding site [chemical binding]; other site 521674005659 activation loop (A-loop); other site 521674005660 DNA gyrase subunit A; Validated; Region: PRK05560 521674005661 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521674005662 CAP-like domain; other site 521674005663 active site 521674005664 primary dimer interface [polypeptide binding]; other site 521674005665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674005666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674005667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674005668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674005669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521674005670 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 521674005671 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521674005672 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521674005673 dihydroorotase; Validated; Region: pyrC; PRK09357 521674005674 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674005675 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 521674005676 active site 521674005677 YacP-like NYN domain; Region: NYN_YacP; cl01491 521674005678 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 521674005679 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521674005680 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 521674005681 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 521674005682 Nitrogen regulatory protein P-II; Region: P-II; smart00938 521674005683 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 521674005684 Nitrogen regulatory protein P-II; Region: P-II; smart00938 521674005685 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 521674005686 PII uridylyl-transferase; Provisional; Region: PRK05092 521674005687 metal binding triad; other site 521674005688 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 521674005689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674005690 Zn2+ binding site [ion binding]; other site 521674005691 Mg2+ binding site [ion binding]; other site 521674005692 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674005693 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 521674005694 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 521674005695 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 521674005696 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 521674005697 dimerization interface [polypeptide binding]; other site 521674005698 active site 521674005699 Global regulator protein family; Region: CsrA; pfam02599 521674005700 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 521674005701 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 521674005702 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 521674005703 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 521674005704 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 521674005705 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 521674005706 GatB domain; Region: GatB_Yqey; smart00845 521674005707 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674005708 aconitate hydratase; Validated; Region: PRK09277 521674005709 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 521674005710 substrate binding site [chemical binding]; other site 521674005711 ligand binding site [chemical binding]; other site 521674005712 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 521674005713 substrate binding site [chemical binding]; other site 521674005714 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 521674005715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674005716 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 521674005717 substrate binding site [chemical binding]; other site 521674005718 active site 521674005719 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 521674005720 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 521674005721 active site 521674005722 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 521674005723 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 521674005724 putative hydrolase; Provisional; Region: PRK02113 521674005725 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005726 Sulfatase; Region: Sulfatase; pfam00884 521674005727 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674005728 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674005729 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521674005730 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521674005731 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521674005732 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 521674005733 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 521674005734 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 521674005735 molybdopterin cofactor binding site; other site 521674005736 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 521674005737 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521674005738 FMN binding site [chemical binding]; other site 521674005739 active site 521674005740 catalytic residues [active] 521674005741 substrate binding site [chemical binding]; other site 521674005742 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 521674005743 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 521674005744 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 521674005745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674005746 ATP binding site [chemical binding]; other site 521674005747 putative Mg++ binding site [ion binding]; other site 521674005748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674005749 nucleotide binding region [chemical binding]; other site 521674005750 ATP-binding site [chemical binding]; other site 521674005751 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 521674005752 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 521674005753 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 521674005754 active site 521674005755 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 521674005756 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 521674005757 putative ligand binding site [chemical binding]; other site 521674005758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521674005759 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 521674005760 TM-ABC transporter signature motif; other site 521674005761 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 521674005762 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 521674005763 TM-ABC transporter signature motif; other site 521674005764 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 521674005765 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 521674005766 Walker A/P-loop; other site 521674005767 ATP binding site [chemical binding]; other site 521674005768 Q-loop/lid; other site 521674005769 ABC transporter signature motif; other site 521674005770 Walker B; other site 521674005771 D-loop; other site 521674005772 H-loop/switch region; other site 521674005773 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 521674005774 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 521674005775 Walker A/P-loop; other site 521674005776 ATP binding site [chemical binding]; other site 521674005777 Q-loop/lid; other site 521674005778 ABC transporter signature motif; other site 521674005779 Walker B; other site 521674005780 D-loop; other site 521674005781 H-loop/switch region; other site 521674005782 Predicted amidohydrolase [General function prediction only]; Region: COG0388 521674005783 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 521674005784 active site 521674005785 catalytic triad [active] 521674005786 dimer interface [polypeptide binding]; other site 521674005787 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 521674005788 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674005789 metal ion-dependent adhesion site (MIDAS); other site 521674005790 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521674005791 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674005792 metal ion-dependent adhesion site (MIDAS); other site 521674005793 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674005794 Daxx Family; Region: Daxx; pfam03344 521674005795 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 521674005796 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 521674005797 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 521674005798 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 521674005799 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 521674005800 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 521674005801 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 521674005802 active site 521674005803 hydrophilic channel; other site 521674005804 dimerization interface [polypeptide binding]; other site 521674005805 catalytic residues [active] 521674005806 active site lid [active] 521674005807 spermidine synthase; Provisional; Region: PRK00811 521674005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005809 S-adenosylmethionine binding site [chemical binding]; other site 521674005810 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 521674005811 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 521674005812 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521674005813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521674005814 active site 521674005815 dimerization interface [polypeptide binding]; other site 521674005816 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 521674005817 metal binding triad; other site 521674005818 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 521674005819 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 521674005820 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 521674005821 metal binding triad; other site 521674005822 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 521674005823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521674005824 Ligand Binding Site [chemical binding]; other site 521674005825 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521674005826 Ligand Binding Site [chemical binding]; other site 521674005827 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521674005828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674005829 dimer interface [polypeptide binding]; other site 521674005830 phosphorylation site [posttranslational modification] 521674005831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674005832 ATP binding site [chemical binding]; other site 521674005833 Mg2+ binding site [ion binding]; other site 521674005834 G-X-G motif; other site 521674005835 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674005837 active site 521674005838 phosphorylation site [posttranslational modification] 521674005839 intermolecular recognition site; other site 521674005840 dimerization interface [polypeptide binding]; other site 521674005841 Hpt domain; Region: Hpt; pfam01627 521674005842 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674005843 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674005844 Walker A/P-loop; other site 521674005845 ATP binding site [chemical binding]; other site 521674005846 Q-loop/lid; other site 521674005847 ABC transporter signature motif; other site 521674005848 Walker B; other site 521674005849 D-loop; other site 521674005850 H-loop/switch region; other site 521674005851 Response regulator receiver domain; Region: Response_reg; pfam00072 521674005852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674005853 active site 521674005854 phosphorylation site [posttranslational modification] 521674005855 intermolecular recognition site; other site 521674005856 dimerization interface [polypeptide binding]; other site 521674005857 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521674005858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521674005859 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 521674005860 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 521674005861 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 521674005862 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 521674005863 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521674005864 nucleotide binding site [chemical binding]; other site 521674005865 substrate binding site [chemical binding]; other site 521674005866 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 521674005867 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521674005868 nucleotide binding site [chemical binding]; other site 521674005869 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674005870 SBD interface [polypeptide binding]; other site 521674005871 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521674005872 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 521674005873 substrate binding site [chemical binding]; other site 521674005874 ATP binding site [chemical binding]; other site 521674005875 ApbE family; Region: ApbE; pfam02424 521674005876 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521674005877 FMN-binding domain; Region: FMN_bind; pfam04205 521674005878 FMN-binding domain; Region: FMN_bind; pfam04205 521674005879 4Fe-4S binding domain; Region: Fer4_5; pfam12801 521674005880 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 521674005881 putative metal binding site [ion binding]; other site 521674005882 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521674005883 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 521674005884 PQQ-like domain; Region: PQQ_2; pfam13360 521674005885 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674005886 active site 521674005887 PQQ-like domain; Region: PQQ_2; pfam13360 521674005888 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674005889 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 521674005890 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674005891 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 521674005892 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521674005893 active site 521674005894 Int/Topo IB signature motif; other site 521674005895 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 521674005896 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674005897 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674005898 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674005899 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674005900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674005901 S-adenosylmethionine binding site [chemical binding]; other site 521674005902 cobalt transport protein CbiM; Validated; Region: PRK06265 521674005903 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 521674005904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674005905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674005906 peptide chain release factor 2; Validated; Region: prfB; PRK00578 521674005907 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521674005908 RF-1 domain; Region: RF-1; pfam00472 521674005909 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521674005910 Ligand Binding Site [chemical binding]; other site 521674005911 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674005912 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674005913 TPR repeat; Region: TPR_11; pfam13414 521674005914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674005915 binding surface 521674005916 TPR motif; other site 521674005917 TPR repeat; Region: TPR_11; pfam13414 521674005918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674005919 binding surface 521674005920 TPR motif; other site 521674005921 TPR repeat; Region: TPR_11; pfam13414 521674005922 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 521674005923 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 521674005924 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 521674005925 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 521674005926 trimer interface [polypeptide binding]; other site 521674005927 active site 521674005928 UDP-GlcNAc binding site [chemical binding]; other site 521674005929 lipid binding site [chemical binding]; lipid-binding site 521674005930 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521674005931 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521674005932 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521674005933 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521674005934 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521674005935 Surface antigen; Region: Bac_surface_Ag; pfam01103 521674005936 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 521674005937 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 521674005938 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674005939 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 521674005940 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521674005941 Cl- selectivity filter; other site 521674005942 Cl- binding residues [ion binding]; other site 521674005943 pore gating glutamate residue; other site 521674005944 dimer interface [polypeptide binding]; other site 521674005945 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521674005946 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 521674005947 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 521674005948 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 521674005949 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 521674005950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674005951 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521674005952 putative acyl-acceptor binding pocket; other site 521674005953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521674005954 acyl-activating enzyme (AAE) consensus motif; other site 521674005955 AMP binding site [chemical binding]; other site 521674005956 active site 521674005957 CoA binding site [chemical binding]; other site 521674005958 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 521674005959 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005960 Sulfatase; Region: Sulfatase; pfam00884 521674005961 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005962 Sulfatase; Region: Sulfatase; pfam00884 521674005963 Protein of unknown function (DUF502); Region: DUF502; cl01107 521674005964 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005965 Sulfatase; Region: Sulfatase; pfam00884 521674005966 PQQ-like domain; Region: PQQ_2; pfam13360 521674005967 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674005968 active site 521674005969 Trp docking motif [polypeptide binding]; other site 521674005970 YHYH protein; Region: YHYH; pfam14240 521674005971 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005972 Sulfatase; Region: Sulfatase; pfam00884 521674005973 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 521674005974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674005975 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 521674005976 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674005977 Sulfatase; Region: Sulfatase; pfam00884 521674005978 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674005979 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674005980 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674005981 Protein of unknown function (DUF971); Region: DUF971; pfam06155 521674005982 putative DNA binding site [nucleotide binding]; other site 521674005983 dimerization interface [polypeptide binding]; other site 521674005984 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 521674005985 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 521674005986 putative Zn2+ binding site [ion binding]; other site 521674005987 NADH dehydrogenase subunit B; Validated; Region: PRK06411 521674005988 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 521674005989 FeS assembly ATPase SufC; Region: sufC; TIGR01978 521674005990 Walker A/P-loop; other site 521674005991 ATP binding site [chemical binding]; other site 521674005992 Q-loop/lid; other site 521674005993 ABC transporter signature motif; other site 521674005994 Walker B; other site 521674005995 D-loop; other site 521674005996 H-loop/switch region; other site 521674005997 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 521674005998 FeS assembly protein SufB; Region: sufB; TIGR01980 521674005999 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 521674006000 FeS assembly protein SufD; Region: sufD; TIGR01981 521674006001 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 521674006002 [2Fe-2S] cluster binding site [ion binding]; other site 521674006003 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 521674006004 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 521674006005 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674006006 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674006007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521674006008 active site 521674006009 phosphorylation site [posttranslational modification] 521674006010 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 521674006011 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 521674006012 Protein phosphatase 2C; Region: PP2C; pfam00481 521674006013 active site 521674006014 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 521674006015 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 521674006016 active site 521674006017 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674006018 anti sigma factor interaction site; other site 521674006019 regulatory phosphorylation site [posttranslational modification]; other site 521674006020 hypothetical protein; Provisional; Region: PRK04194 521674006021 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674006022 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674006023 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674006024 structural tetrad; other site 521674006025 polyphosphate kinase; Provisional; Region: PRK05443 521674006026 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 521674006027 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 521674006028 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 521674006029 putative domain interface [polypeptide binding]; other site 521674006030 putative active site [active] 521674006031 catalytic site [active] 521674006032 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 521674006033 putative domain interface [polypeptide binding]; other site 521674006034 putative active site [active] 521674006035 catalytic site [active] 521674006036 exopolyphosphatase; Region: exo_poly_only; TIGR03706 521674006037 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521674006038 nucleotide binding site [chemical binding]; other site 521674006039 N-acetylmannosamine kinase; Provisional; Region: PRK05082 521674006040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521674006041 nucleotide binding site [chemical binding]; other site 521674006042 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 521674006043 CoA binding domain; Region: CoA_binding; smart00881 521674006044 CoA-ligase; Region: Ligase_CoA; pfam00549 521674006045 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 521674006046 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 521674006047 CoA-ligase; Region: Ligase_CoA; pfam00549 521674006048 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 521674006049 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 521674006050 active site 521674006051 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 521674006052 hypothetical protein; Provisional; Region: PRK06185 521674006053 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 521674006054 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 521674006055 Ion channel; Region: Ion_trans_2; pfam07885 521674006056 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 521674006057 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 521674006058 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 521674006059 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 521674006060 RNA binding site [nucleotide binding]; other site 521674006061 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521674006062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674006063 putative active site [active] 521674006064 heme pocket [chemical binding]; other site 521674006065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674006066 dimer interface [polypeptide binding]; other site 521674006067 phosphorylation site [posttranslational modification] 521674006068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674006069 ATP binding site [chemical binding]; other site 521674006070 Mg2+ binding site [ion binding]; other site 521674006071 G-X-G motif; other site 521674006072 Response regulator receiver domain; Region: Response_reg; pfam00072 521674006073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006074 active site 521674006075 phosphorylation site [posttranslational modification] 521674006076 intermolecular recognition site; other site 521674006077 dimerization interface [polypeptide binding]; other site 521674006078 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674006079 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006080 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 521674006081 pyruvate phosphate dikinase; Provisional; Region: PRK09279 521674006082 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 521674006083 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521674006084 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521674006085 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674006086 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 521674006087 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521674006088 Protein of unknown function (DUF447); Region: DUF447; pfam04289 521674006089 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 521674006090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674006091 active site 521674006092 HIGH motif; other site 521674006093 nucleotide binding site [chemical binding]; other site 521674006094 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674006095 active site 521674006096 KMSKS motif; other site 521674006097 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 521674006098 tRNA binding surface [nucleotide binding]; other site 521674006099 anticodon binding site; other site 521674006100 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 521674006101 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521674006102 active site 521674006103 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521674006104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674006105 Walker A motif; other site 521674006106 ATP binding site [chemical binding]; other site 521674006107 Walker B motif; other site 521674006108 arginine finger; other site 521674006109 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521674006110 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 521674006111 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 521674006112 putative active site [active] 521674006113 putative metal binding residues [ion binding]; other site 521674006114 signature motif; other site 521674006115 putative triphosphate binding site [ion binding]; other site 521674006116 dimer interface [polypeptide binding]; other site 521674006117 Protein of unknown function (DUF971); Region: DUF971; pfam06155 521674006118 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674006119 active site 521674006120 metal binding site [ion binding]; metal-binding site 521674006121 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 521674006122 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 521674006123 O-Antigen ligase; Region: Wzy_C; pfam04932 521674006124 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 521674006125 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 521674006126 Mg++ binding site [ion binding]; other site 521674006127 putative catalytic motif [active] 521674006128 substrate binding site [chemical binding]; other site 521674006129 TPR repeat; Region: TPR_11; pfam13414 521674006130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521674006131 binding surface 521674006132 Protein of unknown function (DUF502); Region: DUF502; cl01107 521674006133 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 521674006134 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 521674006135 TPP-binding site; other site 521674006136 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521674006137 PYR/PP interface [polypeptide binding]; other site 521674006138 dimer interface [polypeptide binding]; other site 521674006139 TPP binding site [chemical binding]; other site 521674006140 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521674006141 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521674006142 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521674006143 substrate binding pocket [chemical binding]; other site 521674006144 chain length determination region; other site 521674006145 substrate-Mg2+ binding site; other site 521674006146 catalytic residues [active] 521674006147 aspartate-rich region 1; other site 521674006148 active site lid residues [active] 521674006149 aspartate-rich region 2; other site 521674006150 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 521674006151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674006152 active site 521674006153 HIGH motif; other site 521674006154 nucleotide binding site [chemical binding]; other site 521674006155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674006156 active site 521674006157 KMSKS motif; other site 521674006158 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521674006159 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 521674006160 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 521674006161 active site 521674006162 putative DNA-binding cleft [nucleotide binding]; other site 521674006163 dimer interface [polypeptide binding]; other site 521674006164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674006165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674006166 active site 521674006167 ATP binding site [chemical binding]; other site 521674006168 substrate binding site [chemical binding]; other site 521674006169 activation loop (A-loop); other site 521674006170 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674006171 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674006172 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 521674006173 Helix-hairpin-helix motif; Region: HHH; pfam00633 521674006174 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 521674006175 homotrimer interaction site [polypeptide binding]; other site 521674006176 zinc binding site [ion binding]; other site 521674006177 CDP-binding sites; other site 521674006178 PEGA domain; Region: PEGA; pfam08308 521674006179 ribonuclease R; Region: RNase_R; TIGR02063 521674006180 RNB domain; Region: RNB; pfam00773 521674006181 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 521674006182 RNA binding site [nucleotide binding]; other site 521674006183 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 521674006184 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 521674006185 putative Iron-sulfur protein interface [polypeptide binding]; other site 521674006186 proximal heme binding site [chemical binding]; other site 521674006187 distal heme binding site [chemical binding]; other site 521674006188 putative dimer interface [polypeptide binding]; other site 521674006189 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 521674006190 L-aspartate oxidase; Provisional; Region: PRK06175 521674006191 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 521674006192 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 521674006193 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 521674006194 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674006195 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674006196 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 521674006197 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 521674006198 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 521674006199 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006200 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674006201 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521674006202 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521674006203 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 521674006204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674006205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674006206 putative substrate translocation pore; other site 521674006207 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 521674006208 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 521674006209 generic binding surface II; other site 521674006210 generic binding surface I; other site 521674006211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674006212 Zn2+ binding site [ion binding]; other site 521674006213 Mg2+ binding site [ion binding]; other site 521674006214 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 521674006215 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 521674006216 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 521674006217 substrate binding pocket [chemical binding]; other site 521674006218 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 521674006219 B12 binding site [chemical binding]; other site 521674006220 cobalt ligand [ion binding]; other site 521674006221 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 521674006222 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 521674006223 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674006224 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006225 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 521674006226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674006227 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 521674006228 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 521674006229 Competence protein; Region: Competence; pfam03772 521674006230 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 521674006231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 521674006232 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521674006233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674006234 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521674006235 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521674006236 dimerization interface [polypeptide binding]; other site 521674006237 DPS ferroxidase diiron center [ion binding]; other site 521674006238 ion pore; other site 521674006239 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 521674006240 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 521674006241 active site 521674006242 dimer interface [polypeptide binding]; other site 521674006243 PSP1 C-terminal conserved region; Region: PSP1; cl00770 521674006244 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521674006245 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521674006246 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521674006247 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521674006248 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521674006249 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521674006250 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 521674006251 Isochorismatase family; Region: Isochorismatase; pfam00857 521674006252 catalytic triad [active] 521674006253 dimer interface [polypeptide binding]; other site 521674006254 conserved cis-peptide bond; other site 521674006255 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 521674006256 G1 box; other site 521674006257 GTP/Mg2+ binding site [chemical binding]; other site 521674006258 G2 box; other site 521674006259 Switch I region; other site 521674006260 G3 box; other site 521674006261 Switch II region; other site 521674006262 G4 box; other site 521674006263 G5 box; other site 521674006264 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 521674006265 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 521674006266 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521674006267 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 521674006268 Cytochrome c; Region: Cytochrom_C; pfam00034 521674006269 PA14 domain; Region: PA14; cl08459 521674006270 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674006271 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674006272 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674006273 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 521674006274 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521674006275 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521674006276 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674006277 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674006278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674006279 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 521674006280 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674006281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674006282 active site 521674006283 ATP binding site [chemical binding]; other site 521674006284 substrate binding site [chemical binding]; other site 521674006285 activation loop (A-loop); other site 521674006286 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 521674006287 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 521674006288 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674006289 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 521674006290 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 521674006291 prolyl-tRNA synthetase; Provisional; Region: PRK09194 521674006292 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 521674006293 dimer interface [polypeptide binding]; other site 521674006294 motif 1; other site 521674006295 active site 521674006296 motif 2; other site 521674006297 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 521674006298 putative deacylase active site [active] 521674006299 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521674006300 active site 521674006301 motif 3; other site 521674006302 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 521674006303 anticodon binding site; other site 521674006304 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 521674006305 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 521674006306 putative catalytic cysteine [active] 521674006307 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 521674006308 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 521674006309 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 521674006310 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521674006311 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521674006312 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 521674006313 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521674006314 23S rRNA binding site [nucleotide binding]; other site 521674006315 L21 binding site [polypeptide binding]; other site 521674006316 L13 binding site [polypeptide binding]; other site 521674006317 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 521674006318 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 521674006319 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521674006320 dimer interface [polypeptide binding]; other site 521674006321 motif 1; other site 521674006322 active site 521674006323 motif 2; other site 521674006324 motif 3; other site 521674006325 potential frameshift: common BLAST hit: gi|283780428|ref|YP_003371183.1| von Willebrand factor type A 521674006326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521674006327 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674006328 metal ion-dependent adhesion site (MIDAS); other site 521674006329 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521674006330 putative binding surface; other site 521674006331 active site 521674006332 Predicted permeases [General function prediction only]; Region: COG0795 521674006333 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521674006334 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521674006335 UGMP family protein; Validated; Region: PRK09604 521674006336 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 521674006337 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521674006338 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521674006339 protein binding site [polypeptide binding]; other site 521674006340 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521674006341 Catalytic dyad [active] 521674006342 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 521674006343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674006344 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674006345 Walker A/P-loop; other site 521674006346 ATP binding site [chemical binding]; other site 521674006347 Q-loop/lid; other site 521674006348 ABC transporter signature motif; other site 521674006349 Walker B; other site 521674006350 D-loop; other site 521674006351 H-loop/switch region; other site 521674006352 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521674006353 FtsX-like permease family; Region: FtsX; pfam02687 521674006354 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521674006355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674006356 Walker A motif; other site 521674006357 ATP binding site [chemical binding]; other site 521674006358 Walker B motif; other site 521674006359 arginine finger; other site 521674006360 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 521674006361 putative catalytic residues [active] 521674006362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674006363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674006364 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521674006365 oligomerisation interface [polypeptide binding]; other site 521674006366 mobile loop; other site 521674006367 roof hairpin; other site 521674006368 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521674006369 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521674006370 ring oligomerisation interface [polypeptide binding]; other site 521674006371 ATP/Mg binding site [chemical binding]; other site 521674006372 stacking interactions; other site 521674006373 hinge regions; other site 521674006374 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674006375 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521674006376 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521674006377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 521674006378 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674006379 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674006380 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674006381 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 521674006382 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 521674006383 dimer interface [polypeptide binding]; other site 521674006384 catalytic triad [active] 521674006385 peroxidatic and resolving cysteines [active] 521674006386 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 521674006387 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 521674006388 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 521674006389 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 521674006390 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674006391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674006392 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 521674006393 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 521674006394 active site pocket [active] 521674006395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674006396 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006397 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674006398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521674006399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006400 active site 521674006401 phosphorylation site [posttranslational modification] 521674006402 intermolecular recognition site; other site 521674006403 dimerization interface [polypeptide binding]; other site 521674006404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674006405 phosphorylation site [posttranslational modification] 521674006406 dimer interface [polypeptide binding]; other site 521674006407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674006408 ATP binding site [chemical binding]; other site 521674006409 Mg2+ binding site [ion binding]; other site 521674006410 G-X-G motif; other site 521674006411 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674006412 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006413 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521674006414 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521674006415 inhibitor site; inhibition site 521674006416 active site 521674006417 dimer interface [polypeptide binding]; other site 521674006418 catalytic residue [active] 521674006419 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006420 Uncharacterized conserved protein [Function unknown]; Region: COG3379 521674006421 Sulfatase; Region: Sulfatase; cl17466 521674006422 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 521674006423 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 521674006424 motif 1; other site 521674006425 active site 521674006426 motif 2; other site 521674006427 motif 3; other site 521674006428 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521674006429 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 521674006430 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521674006431 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674006432 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674006433 protein binding site [polypeptide binding]; other site 521674006434 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674006435 recombinase A; Provisional; Region: recA; PRK09354 521674006436 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521674006437 hexamer interface [polypeptide binding]; other site 521674006438 Walker A motif; other site 521674006439 ATP binding site [chemical binding]; other site 521674006440 Walker B motif; other site 521674006441 hypothetical protein; Validated; Region: PRK00110 521674006442 TPR repeat; Region: TPR_11; pfam13414 521674006443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006444 binding surface 521674006445 TPR motif; other site 521674006446 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521674006447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006448 binding surface 521674006449 TPR motif; other site 521674006450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006451 binding surface 521674006452 TPR motif; other site 521674006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006454 binding surface 521674006455 TPR motif; other site 521674006456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674006457 Ribosome-binding factor A; Region: RBFA; pfam02033 521674006458 translation initiation factor IF-2; Validated; Region: infB; PRK05306 521674006459 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521674006460 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521674006461 G1 box; other site 521674006462 putative GEF interaction site [polypeptide binding]; other site 521674006463 GTP/Mg2+ binding site [chemical binding]; other site 521674006464 Switch I region; other site 521674006465 G2 box; other site 521674006466 G3 box; other site 521674006467 Switch II region; other site 521674006468 G4 box; other site 521674006469 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521674006470 Translation-initiation factor 2; Region: IF-2; pfam11987 521674006471 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521674006472 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 521674006473 NusA N-terminal domain; Region: NusA_N; pfam08529 521674006474 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521674006475 RNA binding site [nucleotide binding]; other site 521674006476 homodimer interface [polypeptide binding]; other site 521674006477 NusA-like KH domain; Region: KH_5; pfam13184 521674006478 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521674006479 G-X-X-G motif; other site 521674006480 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 521674006481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006482 binding surface 521674006483 TPR motif; other site 521674006484 TPR repeat; Region: TPR_11; pfam13414 521674006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674006486 binding surface 521674006487 TPR motif; other site 521674006488 TPR repeat; Region: TPR_11; pfam13414 521674006489 Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785 521674006490 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521674006491 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521674006492 dimer interface [polypeptide binding]; other site 521674006493 active site 521674006494 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521674006495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521674006496 dimer interface [polypeptide binding]; other site 521674006497 active site 521674006498 acyl carrier protein; Provisional; Region: acpP; PRK00982 521674006499 [acyl-carrier protein] S-malonyltransferase; Region: PLN02752 521674006500 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521674006501 putative phosphate acyltransferase; Provisional; Region: PRK05331 521674006502 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 521674006503 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 521674006504 5-oxoprolinase; Region: PLN02666 521674006505 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 521674006506 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 521674006507 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 521674006508 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 521674006509 active site clefts [active] 521674006510 zinc binding site [ion binding]; other site 521674006511 dimer interface [polypeptide binding]; other site 521674006512 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 521674006513 active site 521674006514 catalytic triad [active] 521674006515 oxyanion hole [active] 521674006516 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521674006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674006518 S-adenosylmethionine binding site [chemical binding]; other site 521674006519 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006520 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674006521 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 521674006522 Kelch motif; Region: Kelch_6; pfam13964 521674006523 Kelch motif; Region: Kelch_6; pfam13964 521674006524 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521674006525 putative catalytic site [active] 521674006526 putative metal binding site [ion binding]; other site 521674006527 putative phosphate binding site [ion binding]; other site 521674006528 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 521674006529 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 521674006530 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521674006531 ligand binding site [chemical binding]; other site 521674006532 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 521674006533 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 521674006534 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 521674006535 active site 521674006536 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 521674006537 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674006538 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 521674006539 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 521674006540 trimer interface I [polypeptide binding]; other site 521674006541 putative substrate binding pocket [chemical binding]; other site 521674006542 trimer interface II [polypeptide binding]; other site 521674006543 Bax inhibitor 1 like; Region: BaxI_1; cl17691 521674006544 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674006545 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521674006546 RNA binding surface [nucleotide binding]; other site 521674006547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521674006548 active site 521674006549 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521674006550 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674006551 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 521674006552 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 521674006553 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521674006554 Low molecular weight phosphatase family; Region: LMWPc; cl00105 521674006555 active site 521674006556 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 521674006557 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 521674006558 lipoyl attachment site [posttranslational modification]; other site 521674006559 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 521674006560 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 521674006561 tetramer interface [polypeptide binding]; other site 521674006562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674006563 catalytic residue [active] 521674006564 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 521674006565 tetramer interface [polypeptide binding]; other site 521674006566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674006567 catalytic residue [active] 521674006568 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 521674006569 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674006570 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674006571 phosphopeptide binding site; other site 521674006572 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674006573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674006574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674006575 DNA binding residues [nucleotide binding] 521674006576 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 521674006577 Lumazine binding domain; Region: Lum_binding; pfam00677 521674006578 Lumazine binding domain; Region: Lum_binding; pfam00677 521674006579 enolase; Provisional; Region: eno; PRK00077 521674006580 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521674006581 dimer interface [polypeptide binding]; other site 521674006582 metal binding site [ion binding]; metal-binding site 521674006583 substrate binding pocket [chemical binding]; other site 521674006584 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674006585 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674006586 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674006587 Domain of unknown function DUF87; Region: DUF87; pfam01935 521674006588 AAA-like domain; Region: AAA_10; pfam12846 521674006589 Transposase IS200 like; Region: Y1_Tnp; cl00848 521674006590 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 521674006591 LssY C-terminus; Region: LssY_C; pfam14067 521674006592 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 521674006593 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 521674006594 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 521674006595 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521674006596 active site 521674006597 ADP/pyrophosphate binding site [chemical binding]; other site 521674006598 dimerization interface [polypeptide binding]; other site 521674006599 allosteric effector site; other site 521674006600 fructose-1,6-bisphosphate binding site; other site 521674006601 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674006602 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 521674006603 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 521674006604 active site 521674006605 dimer interface [polypeptide binding]; other site 521674006606 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 521674006607 Ligand Binding Site [chemical binding]; other site 521674006608 Molecular Tunnel; other site 521674006609 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674006610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674006611 DNA binding residues [nucleotide binding] 521674006612 Ferredoxin [Energy production and conversion]; Region: COG1146 521674006613 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 521674006614 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 521674006615 Bacterial SH3 domain; Region: SH3_3; pfam08239 521674006616 rod shape-determining protein MreB; Provisional; Region: PRK13930 521674006617 MreB and similar proteins; Region: MreB_like; cd10225 521674006618 nucleotide binding site [chemical binding]; other site 521674006619 Mg binding site [ion binding]; other site 521674006620 putative protofilament interaction site [polypeptide binding]; other site 521674006621 RodZ interaction site [polypeptide binding]; other site 521674006622 rod shape-determining protein MreC; Region: MreC; pfam04085 521674006623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521674006624 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521674006625 substrate binding pocket [chemical binding]; other site 521674006626 replicative DNA helicase; Region: DnaB; TIGR00665 521674006627 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521674006628 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521674006629 Walker A motif; other site 521674006630 ATP binding site [chemical binding]; other site 521674006631 Walker B motif; other site 521674006632 DNA binding loops [nucleotide binding] 521674006633 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 521674006634 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521674006635 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521674006636 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521674006637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521674006638 dimer interface [polypeptide binding]; other site 521674006639 ssDNA binding site [nucleotide binding]; other site 521674006640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521674006641 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 521674006642 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521674006643 putative active site [active] 521674006644 catalytic residue [active] 521674006645 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 521674006646 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 521674006647 5S rRNA interface [nucleotide binding]; other site 521674006648 CTC domain interface [polypeptide binding]; other site 521674006649 L16 interface [polypeptide binding]; other site 521674006650 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674006651 Trp docking motif [polypeptide binding]; other site 521674006652 PQQ-like domain; Region: PQQ_2; pfam13360 521674006653 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674006654 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 521674006655 UbiA prenyltransferase family; Region: UbiA; pfam01040 521674006656 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 521674006657 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 521674006658 DNA binding site [nucleotide binding] 521674006659 catalytic residue [active] 521674006660 H2TH interface [polypeptide binding]; other site 521674006661 putative catalytic residues [active] 521674006662 turnover-facilitating residue; other site 521674006663 intercalation triad [nucleotide binding]; other site 521674006664 8OG recognition residue [nucleotide binding]; other site 521674006665 putative reading head residues; other site 521674006666 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 521674006667 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 521674006668 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 521674006669 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 521674006670 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 521674006671 Domain of unknown function (DUF303); Region: DUF303; pfam03629 521674006672 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 521674006673 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521674006674 inhibitor-cofactor binding pocket; inhibition site 521674006675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674006676 catalytic residue [active] 521674006677 haloalkane dehalogenase; Provisional; Region: PRK03592 521674006678 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674006679 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521674006680 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674006681 Ecotin; Region: Ecotin; pfam03974 521674006682 secondary substrate binding site; other site 521674006683 primary substrate binding site; other site 521674006684 inhibition loop; other site 521674006685 dimerization interface [polypeptide binding]; other site 521674006686 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674006687 Sulfatase; Region: Sulfatase; cl17466 521674006688 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674006689 Replication initiation factor; Region: Rep_trans; pfam02486 521674006690 HsdM N-terminal domain; Region: HsdM_N; pfam12161 521674006691 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 521674006692 Methyltransferase domain; Region: Methyltransf_26; pfam13659 521674006693 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521674006694 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 521674006695 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521674006696 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 521674006697 Divergent AAA domain; Region: AAA_4; pfam04326 521674006698 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 521674006699 Virulence protein [General function prediction only]; Region: COG3943 521674006700 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 521674006701 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 521674006702 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521674006703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674006704 ATP binding site [chemical binding]; other site 521674006705 putative Mg++ binding site [ion binding]; other site 521674006706 Eukaryotic metallothionein; Region: Metallothio_Euk; pfam12749 521674006707 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 521674006708 Sulfatase; Region: Sulfatase; cl17466 521674006709 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674006710 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 521674006711 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521674006712 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521674006713 HIGH motif; other site 521674006714 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521674006715 active site 521674006716 KMSKS motif; other site 521674006717 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674006718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 521674006719 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674006720 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 521674006721 SnoaL-like domain; Region: SnoaL_2; pfam12680 521674006722 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 521674006723 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 521674006724 GAF domain; Region: GAF_2; pfam13185 521674006725 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521674006726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674006727 Walker A motif; other site 521674006728 ATP binding site [chemical binding]; other site 521674006729 Walker B motif; other site 521674006730 arginine finger; other site 521674006731 Right handed beta helix region; Region: Beta_helix; pfam13229 521674006732 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 521674006733 4Fe-4S binding domain; Region: Fer4; pfam00037 521674006734 SCP-2 sterol transfer family; Region: SCP2; cl01225 521674006735 MarR family; Region: MarR_2; cl17246 521674006736 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521674006737 cyanophycin synthetase; Provisional; Region: PRK14016 521674006738 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 521674006739 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674006740 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674006741 cyanophycin synthetase; Provisional; Region: PRK14016 521674006742 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521674006743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521674006744 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521674006745 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521674006746 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521674006747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 521674006748 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521674006749 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521674006750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674006751 metal ion-dependent adhesion site (MIDAS); other site 521674006752 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674006753 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674006754 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 521674006755 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 521674006756 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521674006757 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521674006758 active site 521674006759 ADP/pyrophosphate binding site [chemical binding]; other site 521674006760 dimerization interface [polypeptide binding]; other site 521674006761 allosteric effector site; other site 521674006762 fructose-1,6-bisphosphate binding site; other site 521674006763 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674006764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674006765 S-adenosylmethionine binding site [chemical binding]; other site 521674006766 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521674006767 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 521674006768 Probable Catalytic site; other site 521674006769 metal-binding site 521674006770 FAD binding domain; Region: FAD_binding_4; pfam01565 521674006771 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 521674006772 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674006773 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 521674006774 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 521674006775 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 521674006776 Tim44-like domain; Region: Tim44; cl09208 521674006777 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 521674006778 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 521674006779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674006780 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 521674006781 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 521674006782 active site 521674006783 dimer interface [polypeptide binding]; other site 521674006784 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 521674006785 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 521674006786 active site 521674006787 FMN binding site [chemical binding]; other site 521674006788 substrate binding site [chemical binding]; other site 521674006789 3Fe-4S cluster binding site [ion binding]; other site 521674006790 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 521674006791 domain interface; other site 521674006792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521674006793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521674006794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521674006795 dimerization interface [polypeptide binding]; other site 521674006796 FeoA domain; Region: FeoA; cl00838 521674006797 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 521674006798 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 521674006799 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 521674006800 G1 box; other site 521674006801 GTP/Mg2+ binding site [chemical binding]; other site 521674006802 Switch I region; other site 521674006803 G2 box; other site 521674006804 G3 box; other site 521674006805 Switch II region; other site 521674006806 G4 box; other site 521674006807 G5 box; other site 521674006808 Nucleoside recognition; Region: Gate; pfam07670 521674006809 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 521674006810 Nucleoside recognition; Region: Gate; pfam07670 521674006811 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 521674006812 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 521674006813 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 521674006814 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 521674006815 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 521674006816 active site 521674006817 catalytic site [active] 521674006818 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 521674006819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521674006820 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 521674006821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521674006822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521674006823 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 521674006824 Flagellar L-ring protein; Region: FlgH; cl17277 521674006825 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 521674006826 Flagellar P-ring protein; Region: FlgI; pfam02119 521674006827 Rod binding protein; Region: Rod-binding; pfam10135 521674006828 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 521674006829 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521674006830 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521674006831 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521674006832 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 521674006833 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 521674006834 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 521674006835 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 521674006836 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521674006837 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521674006838 inhibitor site; inhibition site 521674006839 active site 521674006840 dimer interface [polypeptide binding]; other site 521674006841 catalytic residue [active] 521674006842 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 521674006843 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 521674006844 active site 521674006845 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 521674006846 active site clefts [active] 521674006847 zinc binding site [ion binding]; other site 521674006848 dimer interface [polypeptide binding]; other site 521674006849 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 521674006850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674006851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521674006852 NAD(P) binding site [chemical binding]; other site 521674006853 active site 521674006854 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 521674006855 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 521674006856 active site 521674006857 catalytic triad [active] 521674006858 oxyanion hole [active] 521674006859 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674006860 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521674006861 active site 521674006862 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 521674006863 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 521674006864 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 521674006865 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 521674006866 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 521674006867 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 521674006868 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521674006869 putative active site [active] 521674006870 substrate binding site [chemical binding]; other site 521674006871 putative cosubstrate binding site; other site 521674006872 catalytic site [active] 521674006873 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521674006874 substrate binding site [chemical binding]; other site 521674006875 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 521674006876 active site 521674006877 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521674006878 Beta-lactamase; Region: Beta-lactamase; pfam00144 521674006879 Putative esterase; Region: Esterase; pfam00756 521674006880 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521674006881 oligomerisation interface [polypeptide binding]; other site 521674006882 mobile loop; other site 521674006883 roof hairpin; other site 521674006884 PQQ-like domain; Region: PQQ_2; pfam13360 521674006885 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674006886 active site 521674006887 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674006888 Cytochrome c; Region: Cytochrom_C; pfam00034 521674006889 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674006890 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521674006891 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521674006892 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521674006893 dimer interface [polypeptide binding]; other site 521674006894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674006895 catalytic residue [active] 521674006896 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674006897 Sulfatase; Region: Sulfatase; pfam00884 521674006898 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 521674006899 putative acyl-acceptor binding pocket; other site 521674006900 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 521674006901 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521674006902 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521674006903 NAD(P) binding site [chemical binding]; other site 521674006904 catalytic residues [active] 521674006905 phytoene desaturase; Region: crtI_fam; TIGR02734 521674006906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674006907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 521674006908 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 521674006909 ribonuclease PH; Reviewed; Region: rph; PRK00173 521674006910 Ribonuclease PH; Region: RNase_PH_bact; cd11362 521674006911 hexamer interface [polypeptide binding]; other site 521674006912 active site 521674006913 HEAT repeats; Region: HEAT_2; pfam13646 521674006914 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 521674006915 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 521674006916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521674006917 inhibitor-cofactor binding pocket; inhibition site 521674006918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674006919 catalytic residue [active] 521674006920 BON domain; Region: BON; pfam04972 521674006921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674006922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674006923 active site 521674006924 ATP binding site [chemical binding]; other site 521674006925 substrate binding site [chemical binding]; other site 521674006926 activation loop (A-loop); other site 521674006927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674006928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674006929 dimer interface [polypeptide binding]; other site 521674006930 phosphorylation site [posttranslational modification] 521674006931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674006932 ATP binding site [chemical binding]; other site 521674006933 Mg2+ binding site [ion binding]; other site 521674006934 G-X-G motif; other site 521674006935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521674006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006937 active site 521674006938 phosphorylation site [posttranslational modification] 521674006939 intermolecular recognition site; other site 521674006940 dimerization interface [polypeptide binding]; other site 521674006941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521674006942 DNA binding site [nucleotide binding] 521674006943 sulfite reductase subunit beta; Provisional; Region: PRK13504 521674006944 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 521674006945 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 521674006946 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674006947 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674006948 anti sigma factor interaction site; other site 521674006949 regulatory phosphorylation site [posttranslational modification]; other site 521674006950 Response regulator receiver domain; Region: Response_reg; pfam00072 521674006951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006952 active site 521674006953 phosphorylation site [posttranslational modification] 521674006954 intermolecular recognition site; other site 521674006955 dimerization interface [polypeptide binding]; other site 521674006956 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521674006957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521674006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006959 active site 521674006960 intermolecular recognition site; other site 521674006961 PAS fold; Region: PAS_4; pfam08448 521674006962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674006963 putative active site [active] 521674006964 heme pocket [chemical binding]; other site 521674006965 PAS fold; Region: PAS_4; pfam08448 521674006966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674006967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674006968 dimer interface [polypeptide binding]; other site 521674006969 phosphorylation site [posttranslational modification] 521674006970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674006971 ATP binding site [chemical binding]; other site 521674006972 Mg2+ binding site [ion binding]; other site 521674006973 G-X-G motif; other site 521674006974 Response regulator receiver domain; Region: Response_reg; pfam00072 521674006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006976 active site 521674006977 phosphorylation site [posttranslational modification] 521674006978 intermolecular recognition site; other site 521674006979 dimerization interface [polypeptide binding]; other site 521674006980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674006981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674006982 active site 521674006983 phosphorylation site [posttranslational modification] 521674006984 intermolecular recognition site; other site 521674006985 dimerization interface [polypeptide binding]; other site 521674006986 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521674006987 putative binding surface; other site 521674006988 active site 521674006989 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521674006990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674006991 catalytic residue [active] 521674006992 Protein of unknown function (DUF721); Region: DUF721; pfam05258 521674006993 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521674006994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674006995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674006996 Walker A/P-loop; other site 521674006997 ATP binding site [chemical binding]; other site 521674006998 Q-loop/lid; other site 521674006999 ABC transporter signature motif; other site 521674007000 Walker B; other site 521674007001 D-loop; other site 521674007002 H-loop/switch region; other site 521674007003 ornithine carbamoyltransferase; Provisional; Region: PRK00779 521674007004 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521674007005 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521674007006 acetylornithine aminotransferase; Provisional; Region: PRK02627 521674007007 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521674007008 inhibitor-cofactor binding pocket; inhibition site 521674007009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674007010 catalytic residue [active] 521674007011 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 521674007012 feedback inhibition sensing region; other site 521674007013 homohexameric interface [polypeptide binding]; other site 521674007014 nucleotide binding site [chemical binding]; other site 521674007015 N-acetyl-L-glutamate binding site [chemical binding]; other site 521674007016 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 521674007017 SpoVG; Region: SpoVG; pfam04026 521674007018 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674007019 Cytochrome C' Region: Cytochrom_C_2; cl01610 521674007020 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674007021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674007022 Walker A motif; other site 521674007023 ATP binding site [chemical binding]; other site 521674007024 Walker B motif; other site 521674007025 arginine finger; other site 521674007026 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 521674007027 proposed catalytic triad [active] 521674007028 active site nucleophile [active] 521674007029 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 521674007030 proposed catalytic triad [active] 521674007031 active site nucleophile [active] 521674007032 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521674007033 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521674007034 dimer interface [polypeptide binding]; other site 521674007035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674007036 catalytic residue [active] 521674007037 Rrf2 family protein; Region: rrf2_super; TIGR00738 521674007038 Transcriptional regulator; Region: Rrf2; pfam02082 521674007039 Predicted peptidase [General function prediction only]; Region: COG4099 521674007040 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 521674007041 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674007042 PQQ-like domain; Region: PQQ_2; pfam13360 521674007043 Trp docking motif [polypeptide binding]; other site 521674007044 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 521674007045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674007046 FeS/SAM binding site; other site 521674007047 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 521674007048 Zeta toxin; Region: Zeta_toxin; pfam06414 521674007049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 521674007050 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007051 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007052 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674007053 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674007054 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674007055 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674007056 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674007057 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674007058 cell division protein MraZ; Reviewed; Region: PRK00326 521674007059 MraZ protein; Region: MraZ; pfam02381 521674007060 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 521674007061 putative dimerization interface [polypeptide binding]; other site 521674007062 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521674007063 putative ligand binding site [chemical binding]; other site 521674007064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521674007065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674007066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674007067 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674007068 Trehalose utilisation; Region: ThuA; pfam06283 521674007069 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674007070 HEAT repeats; Region: HEAT_2; pfam13646 521674007071 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674007072 Protein of unknown function (DUF962); Region: DUF962; pfam06127 521674007073 Outer membrane efflux protein; Region: OEP; pfam02321 521674007074 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 521674007075 homoserine dehydrogenase; Provisional; Region: PRK06349 521674007076 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 521674007077 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521674007078 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 521674007079 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 521674007080 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 521674007081 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007082 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 521674007083 homotrimer interaction site [polypeptide binding]; other site 521674007084 putative active site [active] 521674007085 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674007086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521674007087 active site 521674007088 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521674007089 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 521674007090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 521674007091 active site residue [active] 521674007092 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 521674007093 active site residue [active] 521674007094 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 521674007095 methionine sulfoxide reductase B; Provisional; Region: PRK00222 521674007096 SelR domain; Region: SelR; pfam01641 521674007097 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 521674007098 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007099 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521674007100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674007101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674007102 DNA binding residues [nucleotide binding] 521674007103 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 521674007104 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 521674007105 ligand binding site [chemical binding]; other site 521674007106 NAD binding site [chemical binding]; other site 521674007107 dimerization interface [polypeptide binding]; other site 521674007108 catalytic site [active] 521674007109 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 521674007110 putative L-serine binding site [chemical binding]; other site 521674007111 Peptidase family M48; Region: Peptidase_M48; pfam01435 521674007112 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 521674007113 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 521674007114 substrate binding site [chemical binding]; other site 521674007115 glutamase interaction surface [polypeptide binding]; other site 521674007116 Transposase IS200 like; Region: Y1_Tnp; cl00848 521674007117 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674007118 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674007119 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674007120 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 521674007121 pyrroline-5-carboxylate reductase; Region: PLN02688 521674007122 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 521674007123 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 521674007124 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 521674007125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674007126 active site 521674007127 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007128 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 521674007129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674007130 FeS/SAM binding site; other site 521674007131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674007132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 521674007133 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 521674007134 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521674007135 nucleotide binding pocket [chemical binding]; other site 521674007136 K-X-D-G motif; other site 521674007137 catalytic site [active] 521674007138 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521674007139 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521674007140 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521674007141 Dimer interface [polypeptide binding]; other site 521674007142 BRCT sequence motif; other site 521674007143 Putative peptidase family; Region: Metallopep; pfam12044 521674007144 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 521674007145 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 521674007146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674007147 active site 521674007148 ATP binding site [chemical binding]; other site 521674007149 substrate binding site [chemical binding]; other site 521674007150 activation loop (A-loop); other site 521674007151 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 521674007152 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521674007153 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521674007154 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674007155 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 521674007156 DNA binding residues [nucleotide binding] 521674007157 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674007158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007159 active site 521674007160 phosphorylation site [posttranslational modification] 521674007161 intermolecular recognition site; other site 521674007162 dimerization interface [polypeptide binding]; other site 521674007163 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 521674007164 catalytic site [active] 521674007165 BNR repeat-like domain; Region: BNR_2; pfam13088 521674007166 Asp-box motif; other site 521674007167 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674007168 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674007169 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521674007170 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674007171 anti sigma factor interaction site; other site 521674007172 regulatory phosphorylation site [posttranslational modification]; other site 521674007173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521674007174 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 521674007175 TM-ABC transporter signature motif; other site 521674007176 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 521674007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674007178 Walker A/P-loop; other site 521674007179 ATP binding site [chemical binding]; other site 521674007180 Q-loop/lid; other site 521674007181 ABC transporter signature motif; other site 521674007182 Walker B; other site 521674007183 D-loop; other site 521674007184 H-loop/switch region; other site 521674007185 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 521674007186 MarC family integral membrane protein; Region: MarC; cl00919 521674007187 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 521674007188 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 521674007189 Walker A/P-loop; other site 521674007190 ATP binding site [chemical binding]; other site 521674007191 Q-loop/lid; other site 521674007192 ABC transporter signature motif; other site 521674007193 Walker B; other site 521674007194 D-loop; other site 521674007195 H-loop/switch region; other site 521674007196 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521674007197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674007198 dimer interface [polypeptide binding]; other site 521674007199 conserved gate region; other site 521674007200 putative PBP binding loops; other site 521674007201 ABC-ATPase subunit interface; other site 521674007202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 521674007203 NMT1/THI5 like; Region: NMT1; pfam09084 521674007204 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 521674007205 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674007206 HDOD domain; Region: HDOD; pfam08668 521674007207 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521674007208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521674007209 metal binding site [ion binding]; metal-binding site 521674007210 active site 521674007211 I-site; other site 521674007212 Response regulator receiver domain; Region: Response_reg; pfam00072 521674007213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007214 active site 521674007215 phosphorylation site [posttranslational modification] 521674007216 intermolecular recognition site; other site 521674007217 dimerization interface [polypeptide binding]; other site 521674007218 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 521674007219 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 521674007220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521674007221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007222 active site 521674007223 phosphorylation site [posttranslational modification] 521674007224 intermolecular recognition site; other site 521674007225 dimerization interface [polypeptide binding]; other site 521674007226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521674007227 DNA binding residues [nucleotide binding] 521674007228 dimerization interface [polypeptide binding]; other site 521674007229 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521674007230 23S rRNA interface [nucleotide binding]; other site 521674007231 L3 interface [polypeptide binding]; other site 521674007232 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 521674007233 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 521674007234 MgtE intracellular N domain; Region: MgtE_N; pfam03448 521674007235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521674007236 Divalent cation transporter; Region: MgtE; pfam01769 521674007237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674007238 TPR repeat; Region: TPR_11; pfam13414 521674007239 binding surface 521674007240 TPR motif; other site 521674007241 TPR repeat; Region: TPR_11; pfam13414 521674007242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674007243 binding surface 521674007244 TPR motif; other site 521674007245 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521674007246 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521674007247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674007248 S-adenosylmethionine binding site [chemical binding]; other site 521674007249 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 521674007250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674007251 motif II; other site 521674007252 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 521674007253 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 521674007254 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 521674007255 HEAT repeats; Region: HEAT_2; pfam13646 521674007256 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 521674007257 HEAT repeats; Region: HEAT_2; pfam13646 521674007258 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 521674007259 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 521674007260 HEAT repeats; Region: HEAT_2; pfam13646 521674007261 protein binding surface [polypeptide binding]; other site 521674007262 HEAT repeats; Region: HEAT_2; pfam13646 521674007263 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 521674007264 HEAT repeats; Region: HEAT_2; pfam13646 521674007265 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674007266 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674007267 structural tetrad; other site 521674007268 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007269 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521674007270 aspartate aminotransferase; Provisional; Region: PRK08636 521674007271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674007272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674007273 homodimer interface [polypeptide binding]; other site 521674007274 catalytic residue [active] 521674007275 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 521674007276 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 521674007277 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 521674007278 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521674007279 ParB-like nuclease domain; Region: ParB; smart00470 521674007280 TPR repeat; Region: TPR_11; pfam13414 521674007281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674007282 binding surface 521674007283 TPR motif; other site 521674007284 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 521674007285 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007286 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 521674007287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674007288 non-specific DNA binding site [nucleotide binding]; other site 521674007289 salt bridge; other site 521674007290 sequence-specific DNA binding site [nucleotide binding]; other site 521674007291 Cupin domain; Region: Cupin_2; pfam07883 521674007292 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 521674007293 putative active site [active] 521674007294 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 521674007295 active site 521674007296 dimer interface [polypeptide binding]; other site 521674007297 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 521674007298 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674007299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 521674007300 MOSC domain; Region: MOSC; pfam03473 521674007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674007302 S-adenosylmethionine binding site [chemical binding]; other site 521674007303 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 521674007304 homotrimer interaction site [polypeptide binding]; other site 521674007305 putative active site [active] 521674007306 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 521674007307 catalytic residues [active] 521674007308 dimer interface [polypeptide binding]; other site 521674007309 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 521674007310 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674007311 putative active site [active] 521674007312 putative metal binding site [ion binding]; other site 521674007313 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 521674007314 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 521674007315 active site 521674007316 catalytic triad [active] 521674007317 oxyanion hole [active] 521674007318 specificity pocket; other site 521674007319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674007320 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 521674007321 active site 521674007322 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 521674007323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 521674007324 dimer interface [polypeptide binding]; other site 521674007325 active site 521674007326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521674007327 substrate binding site [chemical binding]; other site 521674007328 catalytic residue [active] 521674007329 Protein of unknown function DUF116; Region: DUF116; pfam01976 521674007330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521674007331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521674007332 substrate binding pocket [chemical binding]; other site 521674007333 chain length determination region; other site 521674007334 substrate-Mg2+ binding site; other site 521674007335 catalytic residues [active] 521674007336 aspartate-rich region 1; other site 521674007337 active site lid residues [active] 521674007338 aspartate-rich region 2; other site 521674007339 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 521674007340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521674007341 Domain of unknown function (DUF202); Region: DUF202; pfam02656 521674007342 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 521674007343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674007344 active site 521674007345 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 521674007346 proposed catalytic triad [active] 521674007347 active site nucleophile [active] 521674007348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521674007349 binding surface 521674007350 TPR motif; other site 521674007351 Uncharacterized conserved protein [Function unknown]; Region: COG4748 521674007352 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 521674007353 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 521674007354 GrpE; Region: GrpE; pfam01025 521674007355 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521674007356 dimer interface [polypeptide binding]; other site 521674007357 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521674007358 chaperone protein DnaJ; Provisional; Region: PRK10767 521674007359 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674007360 HSP70 interaction site [polypeptide binding]; other site 521674007361 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521674007362 Zn binding sites [ion binding]; other site 521674007363 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521674007364 dimer interface [polypeptide binding]; other site 521674007365 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521674007366 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521674007367 ring oligomerisation interface [polypeptide binding]; other site 521674007368 ATP/Mg binding site [chemical binding]; other site 521674007369 stacking interactions; other site 521674007370 hinge regions; other site 521674007371 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521674007372 oligomerisation interface [polypeptide binding]; other site 521674007373 mobile loop; other site 521674007374 roof hairpin; other site 521674007375 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521674007376 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521674007377 ring oligomerisation interface [polypeptide binding]; other site 521674007378 ATP/Mg binding site [chemical binding]; other site 521674007379 stacking interactions; other site 521674007380 hinge regions; other site 521674007381 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674007382 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521674007383 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521674007384 substrate binding pocket [chemical binding]; other site 521674007385 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 521674007386 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 521674007387 Sulfate transporter family; Region: Sulfate_transp; pfam00916 521674007388 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674007389 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007390 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521674007391 active site 521674007392 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674007393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007394 active site 521674007395 phosphorylation site [posttranslational modification] 521674007396 intermolecular recognition site; other site 521674007397 dimerization interface [polypeptide binding]; other site 521674007398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674007399 Walker A motif; other site 521674007400 ATP binding site [chemical binding]; other site 521674007401 Walker B motif; other site 521674007402 arginine finger; other site 521674007403 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 521674007404 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 521674007405 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 521674007406 Substrate binding site; other site 521674007407 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674007408 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674007409 Trp docking motif [polypeptide binding]; other site 521674007410 active site 521674007411 PQQ-like domain; Region: PQQ_2; pfam13360 521674007412 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521674007413 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 521674007414 active site 521674007415 metal binding site [ion binding]; metal-binding site 521674007416 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674007417 Trp docking motif [polypeptide binding]; other site 521674007418 active site 521674007419 PQQ-like domain; Region: PQQ_2; pfam13360 521674007420 PQQ-like domain; Region: PQQ_2; pfam13360 521674007421 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674007422 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674007423 Trp docking motif [polypeptide binding]; other site 521674007424 active site 521674007425 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 521674007426 FHA domain; Region: FHA; pfam00498 521674007427 phosphopeptide binding site; other site 521674007428 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521674007429 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674007430 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674007431 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674007432 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674007433 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 521674007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674007435 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 521674007436 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 521674007437 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 521674007438 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 521674007439 UbiA prenyltransferase family; Region: UbiA; pfam01040 521674007440 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 521674007441 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 521674007442 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 521674007443 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 521674007444 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 521674007445 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 521674007446 Cytochrome c; Region: Cytochrom_C; pfam00034 521674007447 Cytochrome c; Region: Cytochrom_C; pfam00034 521674007448 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 521674007449 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 521674007450 oxalacetate binding site [chemical binding]; other site 521674007451 citrylCoA binding site [chemical binding]; other site 521674007452 coenzyme A binding site [chemical binding]; other site 521674007453 catalytic triad [active] 521674007454 threonine synthase; Validated; Region: PRK06260 521674007455 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 521674007456 homodimer interface [polypeptide binding]; other site 521674007457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674007458 catalytic residue [active] 521674007459 adenylate kinase; Reviewed; Region: adk; PRK00279 521674007460 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521674007461 AMP-binding site [chemical binding]; other site 521674007462 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521674007463 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 521674007464 Peptidase family U32; Region: Peptidase_U32; pfam01136 521674007465 Collagenase; Region: DUF3656; pfam12392 521674007466 Peptidase family U32; Region: Peptidase_U32; cl03113 521674007467 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 521674007468 rhodanese superfamily protein; Provisional; Region: PRK05320 521674007469 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 521674007470 active site residue [active] 521674007471 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674007472 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 521674007473 active site 521674007474 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 521674007475 nucleotide binding site/active site [active] 521674007476 HIT family signature motif; other site 521674007477 catalytic residue [active] 521674007478 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521674007479 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674007480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674007481 active site 521674007482 metal binding site [ion binding]; metal-binding site 521674007483 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 521674007484 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 521674007485 putative NAD(P) binding site [chemical binding]; other site 521674007486 putative substrate binding site [chemical binding]; other site 521674007487 catalytic Zn binding site [ion binding]; other site 521674007488 structural Zn binding site [ion binding]; other site 521674007489 dimer interface [polypeptide binding]; other site 521674007490 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 521674007491 Right handed beta helix region; Region: Beta_helix; pfam13229 521674007492 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 521674007493 Methane oxygenase PmoA; Region: PmoA; pfam14100 521674007494 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 521674007495 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 521674007496 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 521674007497 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 521674007498 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 521674007499 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 521674007500 Methyltransferase domain; Region: Methyltransf_26; pfam13659 521674007501 Protein of unknown function DUF104; Region: DUF104; pfam01954 521674007502 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 521674007503 oligomeric interface; other site 521674007504 putative active site [active] 521674007505 homodimer interface [polypeptide binding]; other site 521674007506 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 521674007507 AAA ATPase domain; Region: AAA_16; pfam13191 521674007508 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 521674007509 hypothetical protein; Provisional; Region: PRK05325 521674007510 SpoVR like protein; Region: SpoVR; pfam04293 521674007511 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 521674007512 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 521674007513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521674007514 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674007515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674007516 Global regulator protein family; Region: CsrA; pfam02599 521674007517 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 521674007518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 521674007519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674007520 ATP binding site [chemical binding]; other site 521674007521 putative Mg++ binding site [ion binding]; other site 521674007522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674007523 nucleotide binding region [chemical binding]; other site 521674007524 ATP-binding site [chemical binding]; other site 521674007525 DEAD/H associated; Region: DEAD_assoc; pfam08494 521674007526 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521674007527 metal ion-dependent adhesion site (MIDAS); other site 521674007528 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 521674007529 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 521674007530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674007531 Zn2+ binding site [ion binding]; other site 521674007532 Mg2+ binding site [ion binding]; other site 521674007533 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674007534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674007535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674007536 DNA binding residues [nucleotide binding] 521674007537 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 521674007538 active site 521674007539 catalytic residues [active] 521674007540 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 521674007541 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521674007542 DNA polymerase I; Provisional; Region: PRK05755 521674007543 active site 521674007544 metal binding site 1 [ion binding]; metal-binding site 521674007545 putative 5' ssDNA interaction site; other site 521674007546 metal binding site 3; metal-binding site 521674007547 metal binding site 2 [ion binding]; metal-binding site 521674007548 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521674007549 putative DNA binding site [nucleotide binding]; other site 521674007550 putative metal binding site [ion binding]; other site 521674007551 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 521674007552 active site 521674007553 catalytic site [active] 521674007554 substrate binding site [chemical binding]; other site 521674007555 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521674007556 active site 521674007557 DNA binding site [nucleotide binding] 521674007558 catalytic site [active] 521674007559 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521674007560 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521674007561 Walker A/P-loop; other site 521674007562 ATP binding site [chemical binding]; other site 521674007563 Q-loop/lid; other site 521674007564 ABC transporter signature motif; other site 521674007565 Walker B; other site 521674007566 D-loop; other site 521674007567 H-loop/switch region; other site 521674007568 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 521674007569 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 521674007570 active site 521674007571 metal binding site [ion binding]; metal-binding site 521674007572 DNA binding site [nucleotide binding] 521674007573 P-loop containing region of AAA domain; Region: AAA_29; cl17516 521674007574 AAA domain; Region: AAA_27; pfam13514 521674007575 TIR domain; Region: TIR_2; pfam13676 521674007576 SIR2-like domain; Region: SIR2_2; pfam13289 521674007577 TIR domain; Region: TIR_2; pfam13676 521674007578 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 521674007579 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674007580 HSP70 interaction site [polypeptide binding]; other site 521674007581 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674007582 HSP70 interaction site [polypeptide binding]; other site 521674007583 Hsp70 protein; Region: HSP70; pfam00012 521674007584 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 521674007585 nucleotide binding site [chemical binding]; other site 521674007586 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674007587 SBD interface [polypeptide binding]; other site 521674007588 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 521674007589 putative active site [active] 521674007590 putative metal binding site [ion binding]; other site 521674007591 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 521674007592 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 521674007593 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 521674007594 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674007595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674007596 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 521674007597 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674007598 active site 521674007599 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674007600 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 521674007601 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 521674007602 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674007603 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521674007605 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 521674007606 putative dimerization interface [polypeptide binding]; other site 521674007607 putative ligand binding site [chemical binding]; other site 521674007608 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521674007609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674007610 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 521674007611 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 521674007612 Ycf46; Provisional; Region: ycf46; CHL00195 521674007613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674007614 Walker A motif; other site 521674007615 ATP binding site [chemical binding]; other site 521674007616 Walker B motif; other site 521674007617 arginine finger; other site 521674007618 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 521674007619 putative DNA binding surface [nucleotide binding]; other site 521674007620 dimer interface [polypeptide binding]; other site 521674007621 beta-clamp/clamp loader binding surface; other site 521674007622 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 521674007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007624 active site 521674007625 phosphorylation site [posttranslational modification] 521674007626 intermolecular recognition site; other site 521674007627 dimerization interface [polypeptide binding]; other site 521674007628 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521674007629 DNA binding residues [nucleotide binding] 521674007630 dimerization interface [polypeptide binding]; other site 521674007631 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 521674007632 PAS domain S-box; Region: sensory_box; TIGR00229 521674007633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674007634 putative active site [active] 521674007635 heme pocket [chemical binding]; other site 521674007636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674007637 dimer interface [polypeptide binding]; other site 521674007638 phosphorylation site [posttranslational modification] 521674007639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674007640 ATP binding site [chemical binding]; other site 521674007641 Mg2+ binding site [ion binding]; other site 521674007642 G-X-G motif; other site 521674007643 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 521674007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674007645 putative substrate translocation pore; other site 521674007646 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 521674007647 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 521674007648 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 521674007649 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 521674007650 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 521674007651 [4Fe-4S] binding site [ion binding]; other site 521674007652 molybdopterin cofactor binding site; other site 521674007653 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 521674007654 molybdopterin cofactor binding site; other site 521674007655 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 521674007656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 521674007657 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 521674007658 sulfite reductase; Provisional; Region: PRK06214 521674007659 Putative Fe-S cluster; Region: FeS; cl17515 521674007660 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 521674007661 FAD binding pocket [chemical binding]; other site 521674007662 FAD binding motif [chemical binding]; other site 521674007663 catalytic residues [active] 521674007664 NAD binding pocket [chemical binding]; other site 521674007665 phosphate binding motif [ion binding]; other site 521674007666 beta-alpha-beta structure motif; other site 521674007667 Response regulator receiver domain; Region: Response_reg; pfam00072 521674007668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007669 active site 521674007670 phosphorylation site [posttranslational modification] 521674007671 intermolecular recognition site; other site 521674007672 dimerization interface [polypeptide binding]; other site 521674007673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674007674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674007675 dimer interface [polypeptide binding]; other site 521674007676 phosphorylation site [posttranslational modification] 521674007677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674007678 ATP binding site [chemical binding]; other site 521674007679 Mg2+ binding site [ion binding]; other site 521674007680 G-X-G motif; other site 521674007681 Response regulator receiver domain; Region: Response_reg; pfam00072 521674007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674007683 active site 521674007684 phosphorylation site [posttranslational modification] 521674007685 intermolecular recognition site; other site 521674007686 dimerization interface [polypeptide binding]; other site 521674007687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674007688 ATP binding site [chemical binding]; other site 521674007689 Mg2+ binding site [ion binding]; other site 521674007690 G-X-G motif; other site 521674007691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674007692 S-adenosylmethionine binding site [chemical binding]; other site 521674007693 Predicted transcriptional regulator [Transcription]; Region: COG2378 521674007694 HTH domain; Region: HTH_11; pfam08279 521674007695 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 521674007696 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521674007697 RHS Repeat; Region: RHS_repeat; pfam05593 521674007698 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521674007699 Microbial transglutaminase; Region: Transglut_prok; pfam09017 521674007700 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 521674007701 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 521674007702 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521674007703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674007704 ATP binding site [chemical binding]; other site 521674007705 putative Mg++ binding site [ion binding]; other site 521674007706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674007707 nucleotide binding region [chemical binding]; other site 521674007708 ATP-binding site [chemical binding]; other site 521674007709 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 521674007710 TIGR02687 family protein; Region: TIGR02687 521674007711 PglZ domain; Region: PglZ; pfam08665 521674007712 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 521674007713 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521674007714 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 521674007715 active site 521674007716 DNA binding site [nucleotide binding] 521674007717 catalytic site [active] 521674007718 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 521674007719 Helix-turn-helix domain; Region: HTH_17; pfam12728 521674007720 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674007721 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 521674007722 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 521674007723 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 521674007724 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 521674007725 FliG C-terminal domain; Region: FliG_C; pfam01706 521674007726 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 521674007727 Flagellar assembly protein FliH; Region: FliH; pfam02108 521674007728 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 521674007729 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 521674007730 Walker A motif/ATP binding site; other site 521674007731 Walker B motif; other site 521674007732 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 521674007733 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 521674007734 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674007735 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674007736 active site 521674007737 ATP binding site [chemical binding]; other site 521674007738 substrate binding site [chemical binding]; other site 521674007739 activation loop (A-loop); other site 521674007740 CAAX protease self-immunity; Region: Abi; pfam02517 521674007741 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 521674007742 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674007743 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674007744 catalytic residues [active] 521674007745 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674007747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521674007748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674007749 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 521674007750 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521674007751 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 521674007752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521674007753 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 521674007754 nudix motif; other site 521674007755 Uncharacterized conserved protein [Function unknown]; Region: COG0585 521674007756 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 521674007757 active site 521674007758 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521674007759 active site 521674007760 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521674007761 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521674007762 dimer interface [polypeptide binding]; other site 521674007763 active site 521674007764 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 521674007765 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 521674007766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 521674007767 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 521674007768 NAD(P) binding site [chemical binding]; other site 521674007769 homotetramer interface [polypeptide binding]; other site 521674007770 homodimer interface [polypeptide binding]; other site 521674007771 active site 521674007772 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 521674007773 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521674007774 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521674007775 putative acyl-acceptor binding pocket; other site 521674007776 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 521674007777 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521674007778 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674007779 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674007780 ATP-dependent DNA ligase; Validated; Region: PRK09247 521674007781 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 521674007782 active site 521674007783 DNA binding site [nucleotide binding] 521674007784 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 521674007785 DNA binding site [nucleotide binding] 521674007786 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 521674007787 Bacterial sugar transferase; Region: Bac_transf; pfam02397 521674007788 Flp/Fap pilin component; Region: Flp_Fap; cl01585 521674007789 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 521674007790 Beta-lactamase; Region: Beta-lactamase; pfam00144 521674007791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521674007792 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 521674007793 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521674007794 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 521674007795 Walker A/P-loop; other site 521674007796 ATP binding site [chemical binding]; other site 521674007797 Q-loop/lid; other site 521674007798 ABC transporter signature motif; other site 521674007799 Walker B; other site 521674007800 D-loop; other site 521674007801 H-loop/switch region; other site 521674007802 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 521674007803 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 521674007804 CAAX protease self-immunity; Region: Abi; pfam02517 521674007805 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674007806 metal ion-dependent adhesion site (MIDAS); other site 521674007807 Predicted transcriptional regulator [Transcription]; Region: COG2378 521674007808 HTH domain; Region: HTH_11; pfam08279 521674007809 WYL domain; Region: WYL; pfam13280 521674007810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 521674007811 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 521674007812 CRISPR-associated protein GSU0052/csb3, Dpsyc system; Region: cas_GSU0052; TIGR04106 521674007813 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 521674007814 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cd09667 521674007815 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 521674007816 HEAT repeats; Region: HEAT_2; pfam13646 521674007817 Domain of unknown function (DUF303); Region: DUF303; pfam03629 521674007818 AAA domain; Region: AAA_23; pfam13476 521674007819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674007820 Walker A/P-loop; other site 521674007821 ATP binding site [chemical binding]; other site 521674007822 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 521674007823 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 521674007824 iron-sulfur cluster [ion binding]; other site 521674007825 [2Fe-2S] cluster binding site [ion binding]; other site 521674007826 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674007827 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674007828 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 521674007829 active site 521674007830 TM2 domain; Region: TM2; pfam05154 521674007831 SlyX; Region: SlyX; pfam04102 521674007832 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674007833 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521674007834 FtsX-like permease family; Region: FtsX; pfam02687 521674007835 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521674007836 FtsX-like permease family; Region: FtsX; pfam02687 521674007837 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674007838 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674007839 Walker A/P-loop; other site 521674007840 ATP binding site [chemical binding]; other site 521674007841 Q-loop/lid; other site 521674007842 ABC transporter signature motif; other site 521674007843 Walker B; other site 521674007844 D-loop; other site 521674007845 H-loop/switch region; other site 521674007846 PEGA domain; Region: PEGA; pfam08308 521674007847 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674007848 CotH protein; Region: CotH; pfam08757 521674007849 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 521674007850 putative metal binding residues [ion binding]; other site 521674007851 signature motif; other site 521674007852 active site 521674007853 polyP binding site; other site 521674007854 substrate binding site [chemical binding]; other site 521674007855 acceptor-phosphate pocket; other site 521674007856 dimer interface [polypeptide binding]; other site 521674007857 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 521674007858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521674007859 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521674007860 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521674007861 HSP70 interaction site [polypeptide binding]; other site 521674007862 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 521674007863 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 521674007864 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 521674007865 active site 521674007866 dimer interface [polypeptide binding]; other site 521674007867 effector binding site; other site 521674007868 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521674007869 TSCPD domain; Region: TSCPD; pfam12637 521674007870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521674007871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674007872 NAD(P) binding site [chemical binding]; other site 521674007873 active site 521674007874 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 521674007875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674007876 Walker A/P-loop; other site 521674007877 ATP binding site [chemical binding]; other site 521674007878 Q-loop/lid; other site 521674007879 ABC transporter signature motif; other site 521674007880 Walker B; other site 521674007881 D-loop; other site 521674007882 H-loop/switch region; other site 521674007883 TOBE-like domain; Region: TOBE_3; pfam12857 521674007884 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 521674007885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674007886 dimer interface [polypeptide binding]; other site 521674007887 conserved gate region; other site 521674007888 putative PBP binding loops; other site 521674007889 ABC-ATPase subunit interface; other site 521674007890 sulfate transport protein; Provisional; Region: cysT; CHL00187 521674007891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521674007892 dimer interface [polypeptide binding]; other site 521674007893 conserved gate region; other site 521674007894 putative PBP binding loops; other site 521674007895 ABC-ATPase subunit interface; other site 521674007896 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 521674007897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521674007898 substrate binding pocket [chemical binding]; other site 521674007899 membrane-bound complex binding site; other site 521674007900 hinge residues; other site 521674007901 Rrf2 family protein; Region: rrf2_super; TIGR00738 521674007902 Transcriptional regulator; Region: Rrf2; pfam02082 521674007903 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 521674007904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674007905 active site 521674007906 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 521674007907 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 521674007908 substrate binding site [chemical binding]; other site 521674007909 active site 521674007910 catalytic residues [active] 521674007911 heterodimer interface [polypeptide binding]; other site 521674007912 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 521674007913 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 521674007914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674007915 catalytic residue [active] 521674007916 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 521674007917 putative nucleotide binding site [chemical binding]; other site 521674007918 uridine monophosphate binding site [chemical binding]; other site 521674007919 homohexameric interface [polypeptide binding]; other site 521674007920 elongation factor Ts; Provisional; Region: tsf; PRK09377 521674007921 UBA/TS-N domain; Region: UBA; pfam00627 521674007922 Elongation factor TS; Region: EF_TS; pfam00889 521674007923 Elongation factor TS; Region: EF_TS; pfam00889 521674007924 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521674007925 rRNA interaction site [nucleotide binding]; other site 521674007926 S8 interaction site; other site 521674007927 putative laminin-1 binding site; other site 521674007928 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007929 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 521674007930 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 521674007931 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674007932 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 521674007933 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 521674007934 domain interfaces; other site 521674007935 active site 521674007936 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 521674007937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674007938 active site 521674007939 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 521674007940 Sulfatase; Region: Sulfatase; cl17466 521674007941 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674007942 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 521674007943 EF-hand domain pair; Region: EF_hand_5; pfam13499 521674007944 Ca2+ binding site [ion binding]; other site 521674007945 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 521674007946 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 521674007947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674007948 S-adenosylmethionine binding site [chemical binding]; other site 521674007949 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 521674007950 L11 interface [polypeptide binding]; other site 521674007951 putative EF-Tu interaction site [polypeptide binding]; other site 521674007952 putative EF-G interaction site [polypeptide binding]; other site 521674007953 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 521674007954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521674007955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521674007956 dimerization interface [polypeptide binding]; other site 521674007957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674007958 dimer interface [polypeptide binding]; other site 521674007959 phosphorylation site [posttranslational modification] 521674007960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674007961 ATP binding site [chemical binding]; other site 521674007962 Mg2+ binding site [ion binding]; other site 521674007963 G-X-G motif; other site 521674007964 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674007965 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674007966 phosphopeptide binding site; other site 521674007967 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521674007968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 521674007969 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521674007970 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521674007971 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 521674007972 active site 521674007973 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521674007974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674007975 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 521674007976 active site 521674007977 metal binding site [ion binding]; metal-binding site 521674007978 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521674007979 hydrophobic ligand binding site; other site 521674007980 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 521674007981 active site 521674007982 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674007983 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674007984 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674007985 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521674007986 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674007987 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521674007988 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 521674007989 active site 521674007990 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 521674007991 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 521674007992 putative active site [active] 521674007993 catalytic triad [active] 521674007994 putative dimer interface [polypeptide binding]; other site 521674007995 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 521674007996 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674007997 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674007998 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521674007999 Nuclease-related domain; Region: NERD; pfam08378 521674008000 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 521674008001 Uncharacterized conserved protein [Function unknown]; Region: COG1359 521674008002 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 521674008003 GAF domain; Region: GAF; pfam01590 521674008004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674008005 Walker A motif; other site 521674008006 ATP binding site [chemical binding]; other site 521674008007 Walker B motif; other site 521674008008 arginine finger; other site 521674008009 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674008010 EVE domain; Region: EVE; cl00728 521674008011 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 521674008012 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674008013 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 521674008014 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 521674008015 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 521674008016 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 521674008017 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 521674008018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674008019 Walker A/P-loop; other site 521674008020 ATP binding site [chemical binding]; other site 521674008021 Q-loop/lid; other site 521674008022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674008023 ABC transporter signature motif; other site 521674008024 Walker B; other site 521674008025 D-loop; other site 521674008026 H-loop/switch region; other site 521674008027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674008028 Walker A/P-loop; other site 521674008029 ATP binding site [chemical binding]; other site 521674008030 Q-loop/lid; other site 521674008031 ABC transporter signature motif; other site 521674008032 Walker B; other site 521674008033 D-loop; other site 521674008034 H-loop/switch region; other site 521674008035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674008036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674008037 putative substrate translocation pore; other site 521674008038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674008039 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674008040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008041 TPR motif; other site 521674008042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674008043 binding surface 521674008044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008045 TPR motif; other site 521674008046 TPR repeat; Region: TPR_11; pfam13414 521674008047 binding surface 521674008048 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 521674008049 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 521674008050 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 521674008051 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 521674008052 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 521674008053 tetramer interface; other site 521674008054 substrate binding site; other site 521674008055 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 521674008056 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 521674008057 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521674008058 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521674008059 putative metal binding site [ion binding]; other site 521674008060 Peptidase of plants and bacteria; Region: BSP; pfam04450 521674008061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521674008062 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521674008063 dimer interface [polypeptide binding]; other site 521674008064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674008065 catalytic residue [active] 521674008066 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521674008067 Beta-lactamase; Region: Beta-lactamase; pfam00144 521674008068 Flagellin N-methylase; Region: FliB; cl00497 521674008069 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 521674008070 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674008071 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370 521674008072 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 521674008073 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521674008074 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 521674008075 ligand binding site [chemical binding]; other site 521674008076 flexible hinge region; other site 521674008077 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 521674008078 hypothetical protein; Provisional; Region: PRK05409 521674008079 DoxX; Region: DoxX; pfam07681 521674008080 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 521674008081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674008082 Coenzyme A binding pocket [chemical binding]; other site 521674008083 Methane oxygenase PmoA; Region: PmoA; pfam14100 521674008084 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521674008085 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 521674008086 hinge region; other site 521674008087 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 521674008088 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 521674008089 domain interfaces; other site 521674008090 active site 521674008091 CHASE3 domain; Region: CHASE3; pfam05227 521674008092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674008093 PAS domain; Region: PAS_9; pfam13426 521674008094 putative active site [active] 521674008095 heme pocket [chemical binding]; other site 521674008096 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 521674008097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674008098 putative active site [active] 521674008099 heme pocket [chemical binding]; other site 521674008100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521674008101 putative active site [active] 521674008102 heme pocket [chemical binding]; other site 521674008103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 521674008104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674008105 dimer interface [polypeptide binding]; other site 521674008106 phosphorylation site [posttranslational modification] 521674008107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674008108 ATP binding site [chemical binding]; other site 521674008109 Mg2+ binding site [ion binding]; other site 521674008110 G-X-G motif; other site 521674008111 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521674008112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674008113 active site 521674008114 phosphorylation site [posttranslational modification] 521674008115 intermolecular recognition site; other site 521674008116 dimerization interface [polypeptide binding]; other site 521674008117 Rhomboid family; Region: Rhomboid; pfam01694 521674008118 NAD synthetase; Provisional; Region: PRK13981 521674008119 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 521674008120 multimer interface [polypeptide binding]; other site 521674008121 active site 521674008122 catalytic triad [active] 521674008123 protein interface 1 [polypeptide binding]; other site 521674008124 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521674008125 homodimer interface [polypeptide binding]; other site 521674008126 NAD binding pocket [chemical binding]; other site 521674008127 ATP binding pocket [chemical binding]; other site 521674008128 Mg binding site [ion binding]; other site 521674008129 active-site loop [active] 521674008130 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 521674008131 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 521674008132 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 521674008133 Cupin domain; Region: Cupin_2; cl17218 521674008134 epoxyqueuosine reductase; Region: TIGR00276 521674008135 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 521674008136 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 521674008137 Secretin and TonB N terminus short domain; Region: STN; pfam07660 521674008138 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674008139 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 521674008140 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 521674008141 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 521674008142 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 521674008143 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 521674008144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521674008145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674008146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674008147 Walker A/P-loop; other site 521674008148 ATP binding site [chemical binding]; other site 521674008149 Q-loop/lid; other site 521674008150 ABC transporter signature motif; other site 521674008151 Walker B; other site 521674008152 D-loop; other site 521674008153 H-loop/switch region; other site 521674008154 KaiC; Region: KaiC; pfam06745 521674008155 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 521674008156 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 521674008157 NADP binding site [chemical binding]; other site 521674008158 active site 521674008159 putative substrate binding site [chemical binding]; other site 521674008160 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521674008161 putative active site [active] 521674008162 Putative methyltransferase; Region: Methyltransf_4; cl17290 521674008163 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 521674008164 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521674008165 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521674008166 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521674008167 dimer interface [polypeptide binding]; other site 521674008168 anticodon binding site; other site 521674008169 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521674008170 homodimer interface [polypeptide binding]; other site 521674008171 motif 1; other site 521674008172 active site 521674008173 motif 2; other site 521674008174 GAD domain; Region: GAD; pfam02938 521674008175 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521674008176 motif 3; other site 521674008177 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008178 Sulfatase; Region: Sulfatase; pfam00884 521674008179 hypothetical protein; Provisional; Region: PRK11281 521674008180 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 521674008181 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521674008182 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 521674008183 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 521674008184 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521674008185 homodimer interface [polypeptide binding]; other site 521674008186 substrate-cofactor binding pocket; other site 521674008187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674008188 catalytic residue [active] 521674008189 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 521674008190 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 521674008191 Cytochrome c; Region: Cytochrom_C; pfam00034 521674008192 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 521674008193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674008194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521674008195 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521674008196 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 521674008197 lipoyl attachment site [posttranslational modification]; other site 521674008198 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 521674008199 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 521674008200 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674008201 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521674008202 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 521674008203 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674008204 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521674008205 DNA interaction; other site 521674008206 Metal-binding active site; metal-binding site 521674008207 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 521674008208 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 521674008209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674008210 FeS/SAM binding site; other site 521674008211 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 521674008212 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 521674008213 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 521674008214 putative ligand binding site [chemical binding]; other site 521674008215 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 521674008216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674008217 Zn2+ binding site [ion binding]; other site 521674008218 Mg2+ binding site [ion binding]; other site 521674008219 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 521674008220 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521674008221 active site 521674008222 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 521674008223 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 521674008224 active site 521674008225 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521674008226 active site 521674008227 Acyl transferase domain; Region: Acyl_transf_1; cl08282 521674008228 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521674008229 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521674008230 active site 2 [active] 521674008231 active site 1 [active] 521674008232 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 521674008233 active site 1 [active] 521674008234 dimer interface [polypeptide binding]; other site 521674008235 active site 2 [active] 521674008236 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 521674008237 active site 2 [active] 521674008238 dimer interface [polypeptide binding]; other site 521674008239 active site 1 [active] 521674008240 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521674008241 active site 2 [active] 521674008242 active site 1 [active] 521674008243 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521674008244 NAD(P) binding site [chemical binding]; other site 521674008245 catalytic residues [active] 521674008246 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 521674008247 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521674008248 benzoate transport; Region: 2A0115; TIGR00895 521674008249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674008250 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521674008251 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674008252 Barstar (barnase inhibitor); Region: Barstar; pfam01337 521674008253 RNAase interaction site [polypeptide binding]; other site 521674008254 ribonuclease; Region: Ribonuclease; pfam00545 521674008255 active site 521674008256 trigger factor; Region: tig; TIGR00115 521674008257 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521674008258 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521674008259 Clp protease; Region: CLP_protease; pfam00574 521674008260 oligomer interface [polypeptide binding]; other site 521674008261 active site residues [active] 521674008262 Clp protease; Region: CLP_protease; pfam00574 521674008263 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521674008264 oligomer interface [polypeptide binding]; other site 521674008265 active site residues [active] 521674008266 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 521674008267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674008268 ABC transporter signature motif; other site 521674008269 Walker B; other site 521674008270 D-loop; other site 521674008271 H-loop/switch region; other site 521674008272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674008273 active site 521674008274 metal binding site [ion binding]; metal-binding site 521674008275 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 521674008276 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 521674008277 active site 521674008278 HIGH motif; other site 521674008279 nucleotide binding site [chemical binding]; other site 521674008280 active site 521674008281 KMSKS motif; other site 521674008282 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008283 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521674008284 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 521674008285 substrate binding site [chemical binding]; other site 521674008286 ATP binding site [chemical binding]; other site 521674008287 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 521674008288 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 521674008289 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 521674008290 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521674008291 minor groove reading motif; other site 521674008292 helix-hairpin-helix signature motif; other site 521674008293 substrate binding pocket [chemical binding]; other site 521674008294 active site 521674008295 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 521674008296 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 521674008297 DNA binding and oxoG recognition site [nucleotide binding] 521674008298 Aflatoxin regulatory protein; Region: AflR; pfam08493 521674008299 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521674008300 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521674008301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008302 binding surface 521674008303 TPR motif; other site 521674008304 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 521674008305 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 521674008306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674008307 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521674008308 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521674008309 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521674008310 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521674008311 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 521674008312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521674008313 FeS/SAM binding site; other site 521674008314 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 521674008315 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 521674008316 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 521674008317 dimer interface [polypeptide binding]; other site 521674008318 putative functional site; other site 521674008319 putative MPT binding site; other site 521674008320 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521674008321 active site 521674008322 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674008323 protein binding site [polypeptide binding]; other site 521674008324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674008325 protein binding site [polypeptide binding]; other site 521674008326 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674008327 RIP metalloprotease RseP; Region: TIGR00054 521674008328 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674008329 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521674008330 putative substrate binding region [chemical binding]; other site 521674008331 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 521674008332 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 521674008333 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 521674008334 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 521674008335 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 521674008336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 521674008337 Integral membrane protein TerC family; Region: TerC; cl10468 521674008338 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 521674008339 Response regulator receiver domain; Region: Response_reg; pfam00072 521674008340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674008341 active site 521674008342 phosphorylation site [posttranslational modification] 521674008343 intermolecular recognition site; other site 521674008344 dimerization interface [polypeptide binding]; other site 521674008345 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521674008346 putative binding surface; other site 521674008347 active site 521674008348 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674008349 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674008350 active site 521674008351 ATP binding site [chemical binding]; other site 521674008352 substrate binding site [chemical binding]; other site 521674008353 activation loop (A-loop); other site 521674008354 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 521674008355 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674008356 active site 521674008357 metal binding site [ion binding]; metal-binding site 521674008358 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 521674008359 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 521674008360 putative active site [active] 521674008361 PhoH-like protein; Region: PhoH; pfam02562 521674008362 Chlorite dismutase; Region: Chlor_dismutase; cl01280 521674008363 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 521674008364 ADP-ribose binding site [chemical binding]; other site 521674008365 lipoyl synthase; Provisional; Region: PRK05481 521674008366 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 521674008367 Domain of unknown function (DUF329); Region: DUF329; pfam03884 521674008368 hypothetical protein; Reviewed; Region: PRK09588 521674008369 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 521674008370 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521674008371 Type II/IV secretion system protein; Region: T2SE; pfam00437 521674008372 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521674008373 Walker A motif; other site 521674008374 ATP binding site [chemical binding]; other site 521674008375 Walker B motif; other site 521674008376 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674008377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674008378 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521674008379 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 521674008380 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521674008381 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 521674008382 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008383 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674008384 Sulfatase; Region: Sulfatase; pfam00884 521674008385 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008386 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521674008387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674008388 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674008389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674008390 active site 521674008391 ATP binding site [chemical binding]; other site 521674008392 substrate binding site [chemical binding]; other site 521674008393 activation loop (A-loop); other site 521674008394 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008395 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674008396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521674008397 Metal-binding active site; metal-binding site 521674008398 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 521674008399 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 521674008400 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521674008401 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674008402 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521674008403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521674008404 Walker A motif; other site 521674008405 ATP binding site [chemical binding]; other site 521674008406 Walker B motif; other site 521674008407 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521674008408 DnaA box-binding interface [nucleotide binding]; other site 521674008409 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 521674008410 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 521674008411 NADP-binding site; other site 521674008412 homotetramer interface [polypeptide binding]; other site 521674008413 substrate binding site [chemical binding]; other site 521674008414 homodimer interface [polypeptide binding]; other site 521674008415 active site 521674008416 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 521674008417 putative active site pocket [active] 521674008418 4-fold oligomerization interface [polypeptide binding]; other site 521674008419 metal binding residues [ion binding]; metal-binding site 521674008420 3-fold/trimer interface [polypeptide binding]; other site 521674008421 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 521674008422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674008423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674008424 homodimer interface [polypeptide binding]; other site 521674008425 catalytic residue [active] 521674008426 BON domain; Region: BON; pfam04972 521674008427 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 521674008428 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 521674008429 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 521674008430 active site 521674008431 putative lithium-binding site [ion binding]; other site 521674008432 substrate binding site [chemical binding]; other site 521674008433 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008434 Sulfatase; Region: Sulfatase; cl17466 521674008435 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 521674008436 N- and C-terminal domain interface [polypeptide binding]; other site 521674008437 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 521674008438 active site 521674008439 putative catalytic site [active] 521674008440 metal binding site [ion binding]; metal-binding site 521674008441 ATP binding site [chemical binding]; other site 521674008442 carbohydrate binding site [chemical binding]; other site 521674008443 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 521674008444 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 521674008445 active site 521674008446 dimer interface [polypeptide binding]; other site 521674008447 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 521674008448 Ligand Binding Site [chemical binding]; other site 521674008449 Molecular Tunnel; other site 521674008450 Helix-turn-helix domain; Region: HTH_17; cl17695 521674008451 Predicted dehydrogenase [General function prediction only]; Region: COG0579 521674008452 hydroxyglutarate oxidase; Provisional; Region: PRK11728 521674008453 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 521674008454 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 521674008455 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521674008456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674008457 Coenzyme A binding pocket [chemical binding]; other site 521674008458 Global regulator protein family; Region: CsrA; cl00670 521674008459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674008460 S-adenosylmethionine binding site [chemical binding]; other site 521674008461 BON domain; Region: BON; pfam04972 521674008462 BON domain; Region: BON; pfam04972 521674008463 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674008464 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674008465 Walker A/P-loop; other site 521674008466 ATP binding site [chemical binding]; other site 521674008467 Q-loop/lid; other site 521674008468 ABC transporter signature motif; other site 521674008469 Walker B; other site 521674008470 D-loop; other site 521674008471 H-loop/switch region; other site 521674008472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674008473 dimerization interface [polypeptide binding]; other site 521674008474 putative DNA binding site [nucleotide binding]; other site 521674008475 putative Zn2+ binding site [ion binding]; other site 521674008476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521674008477 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521674008478 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521674008479 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521674008480 homodimer interface [polypeptide binding]; other site 521674008481 NADP binding site [chemical binding]; other site 521674008482 substrate binding site [chemical binding]; other site 521674008483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521674008484 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674008485 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521674008486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674008487 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674008488 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 521674008489 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674008490 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674008491 Protein kinase domain; Region: Pkinase; pfam00069 521674008492 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674008493 active site 521674008494 ATP binding site [chemical binding]; other site 521674008495 substrate binding site [chemical binding]; other site 521674008496 activation loop (A-loop); other site 521674008497 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 521674008498 catalytic site [active] 521674008499 BNR repeat-like domain; Region: BNR_2; pfam13088 521674008500 Asp-box motif; other site 521674008501 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 521674008502 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 521674008503 Na binding site [ion binding]; other site 521674008504 putative glycosylation site [posttranslational modification]; other site 521674008505 putative glycosylation site [posttranslational modification]; other site 521674008506 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008507 G8 domain; Region: G8; pfam10162 521674008508 methionine sulfoxide reductase A; Provisional; Region: PRK14054 521674008509 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521674008510 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 521674008511 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 521674008512 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674008513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674008514 active site 521674008515 ATP binding site [chemical binding]; other site 521674008516 substrate binding site [chemical binding]; other site 521674008517 activation loop (A-loop); other site 521674008518 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674008519 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674008520 structural tetrad; other site 521674008521 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674008522 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674008523 structural tetrad; other site 521674008524 WD40 repeats; Region: WD40; smart00320 521674008525 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521674008526 Family description; Region: UvrD_C_2; pfam13538 521674008527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521674008528 active site 521674008529 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 521674008530 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 521674008531 catalytic motif [active] 521674008532 Zn binding site [ion binding]; other site 521674008533 RibD C-terminal domain; Region: RibD_C; cl17279 521674008534 Uncharacterized conserved protein [Function unknown]; Region: COG4198 521674008535 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 521674008536 PIN domain; Region: PIN_3; pfam13470 521674008537 Helix-turn-helix domain; Region: HTH_17; cl17695 521674008538 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521674008539 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521674008540 putative dimer interface [polypeptide binding]; other site 521674008541 putative anticodon binding site; other site 521674008542 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521674008543 homodimer interface [polypeptide binding]; other site 521674008544 motif 1; other site 521674008545 motif 2; other site 521674008546 active site 521674008547 motif 3; other site 521674008548 GTP-binding protein LepA; Provisional; Region: PRK05433 521674008549 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521674008550 G1 box; other site 521674008551 putative GEF interaction site [polypeptide binding]; other site 521674008552 GTP/Mg2+ binding site [chemical binding]; other site 521674008553 Switch I region; other site 521674008554 G2 box; other site 521674008555 G3 box; other site 521674008556 Switch II region; other site 521674008557 G4 box; other site 521674008558 G5 box; other site 521674008559 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521674008560 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521674008561 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521674008562 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008563 Sulfatase; Region: Sulfatase; cl17466 521674008564 Global regulator protein family; Region: CsrA; pfam02599 521674008565 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 521674008566 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521674008567 protein binding site [polypeptide binding]; other site 521674008568 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521674008569 Catalytic dyad [active] 521674008570 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 521674008571 Predicted membrane protein [Function unknown]; Region: COG2261 521674008572 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521674008573 active site 521674008574 substrate binding site [chemical binding]; other site 521674008575 metal binding site [ion binding]; metal-binding site 521674008576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674008577 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 521674008578 putative ADP-binding pocket [chemical binding]; other site 521674008579 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 521674008580 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 521674008581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521674008582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521674008583 Walker A/P-loop; other site 521674008584 ATP binding site [chemical binding]; other site 521674008585 Q-loop/lid; other site 521674008586 ABC transporter signature motif; other site 521674008587 Walker B; other site 521674008588 D-loop; other site 521674008589 H-loop/switch region; other site 521674008590 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 521674008591 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674008592 Outer membrane efflux protein; Region: OEP; pfam02321 521674008593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521674008594 MarR family; Region: MarR_2; pfam12802 521674008595 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 521674008596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674008597 active site 521674008598 HIGH motif; other site 521674008599 nucleotide binding site [chemical binding]; other site 521674008600 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 521674008601 KMSKS motif; other site 521674008602 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 521674008603 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 521674008604 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674008606 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 521674008607 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 521674008608 active site residue [active] 521674008609 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521674008610 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521674008611 inhibitor site; inhibition site 521674008612 active site 521674008613 dimer interface [polypeptide binding]; other site 521674008614 catalytic residue [active] 521674008615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521674008616 nudix motif; other site 521674008617 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 521674008618 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 521674008619 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 521674008620 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521674008621 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521674008622 Cysteine-rich domain; Region: CCG; pfam02754 521674008623 Cysteine-rich domain; Region: CCG; pfam02754 521674008624 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 521674008625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674008626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 521674008627 DNA binding residues [nucleotide binding] 521674008628 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 521674008629 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 521674008630 putative active site [active] 521674008631 Zn binding site [ion binding]; other site 521674008632 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008633 Sulfatase; Region: Sulfatase; pfam00884 521674008634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521674008635 catalytic core [active] 521674008636 Flagellin N-methylase; Region: FliB; pfam03692 521674008637 PQQ-like domain; Region: PQQ_2; pfam13360 521674008638 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674008639 Trp docking motif [polypeptide binding]; other site 521674008640 active site 521674008641 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 521674008642 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 521674008643 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 521674008644 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 521674008645 active site 521674008646 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 521674008647 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 521674008648 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674008649 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674008650 HEAT repeats; Region: HEAT_2; pfam13646 521674008651 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521674008652 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674008653 TPR repeat; Region: TPR_11; pfam13414 521674008654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008655 binding surface 521674008656 TPR motif; other site 521674008657 TPR repeat; Region: TPR_11; pfam13414 521674008658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008659 binding surface 521674008660 TPR motif; other site 521674008661 TPR repeat; Region: TPR_11; pfam13414 521674008662 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 521674008663 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 521674008664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674008665 S-adenosylmethionine binding site [chemical binding]; other site 521674008666 Abi-like protein; Region: Abi_2; pfam07751 521674008667 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 521674008668 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 521674008669 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 521674008670 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 521674008671 aspartate aminotransferase; Provisional; Region: PRK05764 521674008672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674008673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674008674 homodimer interface [polypeptide binding]; other site 521674008675 catalytic residue [active] 521674008676 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 521674008677 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 521674008678 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 521674008679 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 521674008680 dimer interface [polypeptide binding]; other site 521674008681 TPP-binding site [chemical binding]; other site 521674008682 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 521674008683 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 521674008684 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521674008685 E3 interaction surface; other site 521674008686 lipoyl attachment site [posttranslational modification]; other site 521674008687 e3 binding domain; Region: E3_binding; pfam02817 521674008688 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521674008689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521674008690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521674008691 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 521674008692 dimerization interface [polypeptide binding]; other site 521674008693 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 521674008694 putative hydrophobic ligand binding site [chemical binding]; other site 521674008695 Domain of unknown function (DUF303); Region: DUF303; pfam03629 521674008696 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521674008697 hydrophobic ligand binding site; other site 521674008698 SWIM zinc finger; Region: SWIM; pfam04434 521674008699 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521674008700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674008701 ATP binding site [chemical binding]; other site 521674008702 putative Mg++ binding site [ion binding]; other site 521674008703 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521674008704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674008705 nucleotide binding region [chemical binding]; other site 521674008706 ATP-binding site [chemical binding]; other site 521674008707 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674008708 anti sigma factor interaction site; other site 521674008709 regulatory phosphorylation site [posttranslational modification]; other site 521674008710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674008711 active site 521674008712 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674008713 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 521674008714 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 521674008715 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521674008716 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 521674008717 homodimer interface [polypeptide binding]; other site 521674008718 substrate-cofactor binding pocket; other site 521674008719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674008720 catalytic residue [active] 521674008721 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 521674008722 hypothetical protein; Provisional; Region: PRK09897 521674008723 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521674008724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674008725 active site 521674008726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674008727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674008728 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 521674008729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674008730 Mg2+ binding site [ion binding]; other site 521674008731 G-X-G motif; other site 521674008732 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 521674008733 ATP binding site [chemical binding]; other site 521674008734 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 521674008735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521674008736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521674008737 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521674008738 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674008739 Trp docking motif [polypeptide binding]; other site 521674008740 active site 521674008741 PQQ-like domain; Region: PQQ_2; pfam13360 521674008742 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 521674008743 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521674008744 RNA binding site [nucleotide binding]; other site 521674008745 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521674008746 RNA binding site [nucleotide binding]; other site 521674008747 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521674008748 RNA binding site [nucleotide binding]; other site 521674008749 domain interface; other site 521674008750 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 521674008751 DNA methylase; Region: N6_N4_Mtase; pfam01555 521674008752 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674008753 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674008754 Uncharacterized conserved protein [Function unknown]; Region: COG1262 521674008755 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521674008756 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 521674008757 Fasciclin domain; Region: Fasciclin; pfam02469 521674008758 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521674008759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674008760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674008761 DNA binding residues [nucleotide binding] 521674008762 Anti-sigma-K factor rskA; Region: RskA; pfam10099 521674008763 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 521674008764 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 521674008765 NAD binding site [chemical binding]; other site 521674008766 substrate binding site [chemical binding]; other site 521674008767 homodimer interface [polypeptide binding]; other site 521674008768 active site 521674008769 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 521674008770 HEAT repeats; Region: HEAT_2; pfam13646 521674008771 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 521674008772 HEAT repeats; Region: HEAT_2; pfam13646 521674008773 protein binding surface [polypeptide binding]; other site 521674008774 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 521674008775 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521674008776 nucleotide binding site [chemical binding]; other site 521674008777 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674008778 SBD interface [polypeptide binding]; other site 521674008779 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 521674008780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008781 binding surface 521674008782 TPR motif; other site 521674008783 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 521674008784 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 521674008785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674008786 TPR motif; other site 521674008787 binding surface 521674008788 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521674008789 putative catalytic site [active] 521674008790 putative metal binding site [ion binding]; other site 521674008791 putative catalytic site [active] 521674008792 putative phosphate binding site [ion binding]; other site 521674008793 putative phosphate binding site [ion binding]; other site 521674008794 putative metal binding site [ion binding]; other site 521674008795 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 521674008796 DNA polymerase III, delta subunit; Region: holA; TIGR01128 521674008797 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674008798 Trp docking motif [polypeptide binding]; other site 521674008799 PQQ-like domain; Region: PQQ_2; pfam13360 521674008800 active site 521674008801 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521674008802 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 521674008803 peptide synthase; Provisional; Region: PRK09274 521674008804 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 521674008805 acyl-activating enzyme (AAE) consensus motif; other site 521674008806 putative AMP binding site [chemical binding]; other site 521674008807 putative active site [active] 521674008808 putative CoA binding site [chemical binding]; other site 521674008809 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521674008810 dephospho-CoA kinase; Region: TIGR00152 521674008811 CoA-binding site [chemical binding]; other site 521674008812 ATP-binding [chemical binding]; other site 521674008813 transcription termination factor Rho; Provisional; Region: rho; PRK09376 521674008814 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 521674008815 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 521674008816 RNA binding site [nucleotide binding]; other site 521674008817 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 521674008818 multimer interface [polypeptide binding]; other site 521674008819 Walker A motif; other site 521674008820 ATP binding site [chemical binding]; other site 521674008821 Walker B motif; other site 521674008822 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 521674008823 homopentamer interface [polypeptide binding]; other site 521674008824 active site 521674008825 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 521674008826 putative RNA binding site [nucleotide binding]; other site 521674008827 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521674008828 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 521674008829 metal binding site [ion binding]; metal-binding site 521674008830 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 521674008831 active site 521674008832 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674008833 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521674008834 catalytic residues [active] 521674008835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 521674008836 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521674008837 Walker A/P-loop; other site 521674008838 ATP binding site [chemical binding]; other site 521674008839 Q-loop/lid; other site 521674008840 ABC transporter signature motif; other site 521674008841 Walker B; other site 521674008842 D-loop; other site 521674008843 H-loop/switch region; other site 521674008844 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 521674008845 Nuclease-related domain; Region: NERD; pfam08378 521674008846 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521674008847 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 521674008848 catalytic motif [active] 521674008849 Zn binding site [ion binding]; other site 521674008850 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 521674008851 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 521674008852 homotetramer interface [polypeptide binding]; other site 521674008853 ligand binding site [chemical binding]; other site 521674008854 catalytic site [active] 521674008855 NAD binding site [chemical binding]; other site 521674008856 competence damage-inducible protein A; Provisional; Region: PRK00549 521674008857 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 521674008858 putative MPT binding site; other site 521674008859 Competence-damaged protein; Region: CinA; pfam02464 521674008860 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521674008861 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521674008862 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 521674008863 nucleoside/Zn binding site; other site 521674008864 dimer interface [polypeptide binding]; other site 521674008865 catalytic motif [active] 521674008866 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521674008867 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674008868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674008869 protein binding site [polypeptide binding]; other site 521674008870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674008871 protein binding site [polypeptide binding]; other site 521674008872 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008873 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521674008874 Cysteine-rich domain; Region: CCG; pfam02754 521674008875 Cysteine-rich domain; Region: CCG; pfam02754 521674008876 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 521674008877 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 521674008878 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 521674008879 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521674008880 putative catalytic site [active] 521674008881 putative metal binding site [ion binding]; other site 521674008882 putative phosphate binding site [ion binding]; other site 521674008883 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674008884 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 521674008885 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 521674008886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674008887 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 521674008888 Family description; Region: VCBS; pfam13517 521674008889 Family description; Region: VCBS; pfam13517 521674008890 Family description; Region: VCBS; pfam13517 521674008891 Family description; Region: VCBS; pfam13517 521674008892 Family description; Region: VCBS; pfam13517 521674008893 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674008894 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674008895 phosphopeptide binding site; other site 521674008896 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674008897 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521674008898 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521674008899 active site 521674008900 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 521674008901 ThiS interaction site; other site 521674008902 putative active site [active] 521674008903 tetramer interface [polypeptide binding]; other site 521674008904 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674008905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674008906 Walker A motif; other site 521674008907 ATP binding site [chemical binding]; other site 521674008908 Walker B motif; other site 521674008909 arginine finger; other site 521674008910 Aerotolerance regulator N-terminal; Region: BatA; cl06567 521674008911 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 521674008912 type II secretion system protein I; Region: gspI; TIGR01707 521674008913 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 521674008914 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 521674008915 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008916 Sulfatase; Region: Sulfatase; cl17466 521674008917 Sulfatase; Region: Sulfatase; cl17466 521674008918 Transposase IS200 like; Region: Y1_Tnp; cl00848 521674008919 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 521674008920 EamA-like transporter family; Region: EamA; pfam00892 521674008921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674008922 non-specific DNA binding site [nucleotide binding]; other site 521674008923 salt bridge; other site 521674008924 sequence-specific DNA binding site [nucleotide binding]; other site 521674008925 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 521674008926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674008927 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 521674008928 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674008929 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674008930 active site 521674008931 ATP binding site [chemical binding]; other site 521674008932 substrate binding site [chemical binding]; other site 521674008933 activation loop (A-loop); other site 521674008934 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674008935 FOG: WD40 repeat [General function prediction only]; Region: COG2319 521674008936 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 521674008937 structural tetrad; other site 521674008938 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 521674008939 Leucine-rich repeats; other site 521674008940 Substrate binding site [chemical binding]; other site 521674008941 Leucine rich repeat; Region: LRR_8; pfam13855 521674008942 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 521674008943 Leucine-rich repeats; other site 521674008944 Substrate binding site [chemical binding]; other site 521674008945 Leucine rich repeat; Region: LRR_8; pfam13855 521674008946 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 521674008947 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 521674008948 Substrate binding site; other site 521674008949 Mg++ binding site; other site 521674008950 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 521674008951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674008952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521674008953 putative substrate translocation pore; other site 521674008954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521674008955 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674008956 active site 521674008957 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 521674008958 active site 521674008959 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674008960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 521674008961 MOSC domain; Region: MOSC; pfam03473 521674008962 3-alpha domain; Region: 3-alpha; pfam03475 521674008963 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 521674008964 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521674008965 dimer interface [polypeptide binding]; other site 521674008966 active site 521674008967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521674008968 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521674008969 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521674008970 FtsX-like permease family; Region: FtsX; pfam02687 521674008971 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674008972 Sulfatase; Region: Sulfatase; pfam00884 521674008973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674008974 S-adenosylmethionine binding site [chemical binding]; other site 521674008975 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674008976 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 521674008977 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 521674008978 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 521674008979 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 521674008980 putative active site [active] 521674008981 catalytic site [active] 521674008982 putative metal binding site [ion binding]; other site 521674008983 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 521674008984 dimer interface [polypeptide binding]; other site 521674008985 substrate binding site [chemical binding]; other site 521674008986 metal binding sites [ion binding]; metal-binding site 521674008987 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521674008988 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674008989 active site 521674008990 ATP binding site [chemical binding]; other site 521674008991 substrate binding site [chemical binding]; other site 521674008992 activation loop (A-loop); other site 521674008993 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521674008994 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521674008995 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 521674008996 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674008997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674008998 Walker A motif; other site 521674008999 ATP binding site [chemical binding]; other site 521674009000 Walker B motif; other site 521674009001 arginine finger; other site 521674009002 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674009003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521674009004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674009005 Walker A/P-loop; other site 521674009006 ATP binding site [chemical binding]; other site 521674009007 Q-loop/lid; other site 521674009008 ABC transporter signature motif; other site 521674009009 Walker B; other site 521674009010 D-loop; other site 521674009011 H-loop/switch region; other site 521674009012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521674009013 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 521674009014 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 521674009015 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521674009016 NAD(P) binding site [chemical binding]; other site 521674009017 catalytic residues [active] 521674009018 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 521674009019 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 521674009020 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521674009021 FMN binding site [chemical binding]; other site 521674009022 active site 521674009023 catalytic residues [active] 521674009024 substrate binding site [chemical binding]; other site 521674009025 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674009026 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674009027 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521674009028 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 521674009029 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 521674009030 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521674009031 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 521674009032 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 521674009033 putative ADP-binding pocket [chemical binding]; other site 521674009034 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 521674009035 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 521674009036 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 521674009037 active site 521674009038 catalytic site [active] 521674009039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521674009040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674009041 Coenzyme A binding pocket [chemical binding]; other site 521674009042 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 521674009043 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674009044 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674009045 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674009046 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674009047 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674009048 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 521674009049 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 521674009050 active site 521674009051 Zn binding site [ion binding]; other site 521674009052 YceI-like domain; Region: YceI; pfam04264 521674009053 PAS domain; Region: PAS; smart00091 521674009054 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 521674009055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674009056 Walker A motif; other site 521674009057 ATP binding site [chemical binding]; other site 521674009058 Walker B motif; other site 521674009059 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674009060 MarR family; Region: MarR_2; cl17246 521674009061 Domain of unknown function (DUF897); Region: DUF897; pfam05982 521674009062 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521674009063 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 521674009064 active site clefts [active] 521674009065 zinc binding site [ion binding]; other site 521674009066 dimer interface [polypeptide binding]; other site 521674009067 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521674009068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521674009069 RNA binding surface [nucleotide binding]; other site 521674009070 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521674009071 active site 521674009072 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 521674009073 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674009074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674009075 active site 521674009076 Response regulator receiver domain; Region: Response_reg; pfam00072 521674009077 phosphorylation site [posttranslational modification] 521674009078 intermolecular recognition site; other site 521674009079 dimerization interface [polypeptide binding]; other site 521674009080 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521674009081 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009082 AAA ATPase domain; Region: AAA_15; pfam13175 521674009083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674009084 Walker A/P-loop; other site 521674009085 ATP binding site [chemical binding]; other site 521674009086 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 521674009087 active site 521674009088 metal binding site [ion binding]; metal-binding site 521674009089 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009090 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009091 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 521674009092 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 521674009093 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 521674009094 homodimer interface [polypeptide binding]; other site 521674009095 active site 521674009096 TDP-binding site; other site 521674009097 acceptor substrate-binding pocket; other site 521674009098 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 521674009099 RibD C-terminal domain; Region: RibD_C; cl17279 521674009100 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 521674009101 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 521674009102 ATP binding site [chemical binding]; other site 521674009103 substrate interface [chemical binding]; other site 521674009104 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 521674009105 ParB-like nuclease domain; Region: ParB; smart00470 521674009106 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674009107 EF-hand domain pair; Region: EF_hand_5; pfam13499 521674009108 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674009109 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674009110 Response regulator receiver domain; Region: Response_reg; pfam00072 521674009111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674009112 active site 521674009113 phosphorylation site [posttranslational modification] 521674009114 intermolecular recognition site; other site 521674009115 dimerization interface [polypeptide binding]; other site 521674009116 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009117 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009118 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 521674009119 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521674009120 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 521674009121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521674009122 ATP binding site [chemical binding]; other site 521674009123 putative Mg++ binding site [ion binding]; other site 521674009124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521674009125 nucleotide binding region [chemical binding]; other site 521674009126 ATP-binding site [chemical binding]; other site 521674009127 TRCF domain; Region: TRCF; pfam03461 521674009128 translocation protein TolB; Provisional; Region: tolB; PRK05137 521674009129 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 521674009130 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 521674009131 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 521674009132 aminoacyl-tRNA ligase; Region: PLN02563 521674009133 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521674009134 HIGH motif; other site 521674009135 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521674009136 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674009137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674009138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521674009139 active site 521674009140 KMSKS motif; other site 521674009141 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521674009142 tRNA binding surface [nucleotide binding]; other site 521674009143 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521674009144 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 521674009145 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674009146 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 521674009147 putative NAD(P) binding site [chemical binding]; other site 521674009148 active site 521674009149 putative substrate binding site [chemical binding]; other site 521674009150 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 521674009151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521674009152 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 521674009153 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 521674009154 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 521674009155 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674009156 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674009157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521674009158 G1 box; other site 521674009159 GTP/Mg2+ binding site [chemical binding]; other site 521674009160 G2 box; other site 521674009161 Switch I region; other site 521674009162 G3 box; other site 521674009163 Switch II region; other site 521674009164 G4 box; other site 521674009165 G5 box; other site 521674009166 KpsF/GutQ family protein; Region: kpsF; TIGR00393 521674009167 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 521674009168 putative active site [active] 521674009169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 521674009170 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 521674009171 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 521674009172 Integral membrane protein DUF95; Region: DUF95; pfam01944 521674009173 RDD family; Region: RDD; pfam06271 521674009174 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 521674009175 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 521674009176 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521674009177 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 521674009178 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 521674009179 Sulfate transporter family; Region: Sulfate_transp; pfam00916 521674009180 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674009181 anti sigma factor interaction site; other site 521674009182 regulatory phosphorylation site [posttranslational modification]; other site 521674009183 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521674009184 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521674009185 Walker A/P-loop; other site 521674009186 ATP binding site [chemical binding]; other site 521674009187 Q-loop/lid; other site 521674009188 ABC transporter signature motif; other site 521674009189 Walker B; other site 521674009190 D-loop; other site 521674009191 H-loop/switch region; other site 521674009192 SLBB domain; Region: SLBB; pfam10531 521674009193 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 521674009194 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 521674009195 NAD(P) binding pocket [chemical binding]; other site 521674009196 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 521674009197 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 521674009198 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 521674009199 UbiA prenyltransferase family; Region: UbiA; pfam01040 521674009200 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 521674009201 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 521674009202 heme binding site [chemical binding]; other site 521674009203 ferroxidase pore; other site 521674009204 ferroxidase diiron center [ion binding]; other site 521674009205 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674009206 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674009207 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521674009208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 521674009209 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 521674009210 Histidine kinase; Region: HisKA_3; pfam07730 521674009211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674009212 ATP binding site [chemical binding]; other site 521674009213 Mg2+ binding site [ion binding]; other site 521674009214 G-X-G motif; other site 521674009215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521674009216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674009217 active site 521674009218 phosphorylation site [posttranslational modification] 521674009219 intermolecular recognition site; other site 521674009220 dimerization interface [polypeptide binding]; other site 521674009221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521674009222 DNA binding residues [nucleotide binding] 521674009223 dimerization interface [polypeptide binding]; other site 521674009224 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009225 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009226 Paraflagellar rod protein; Region: Flagellar_rod; pfam05149 521674009227 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521674009228 ApbE family; Region: ApbE; pfam02424 521674009229 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 521674009230 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 521674009231 Moco binding site; other site 521674009232 metal coordination site [ion binding]; other site 521674009233 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 521674009234 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 521674009235 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 521674009236 FAD binding pocket [chemical binding]; other site 521674009237 FAD binding motif [chemical binding]; other site 521674009238 phosphate binding motif [ion binding]; other site 521674009239 beta-alpha-beta structure motif; other site 521674009240 NAD binding pocket [chemical binding]; other site 521674009241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521674009242 catalytic loop [active] 521674009243 iron binding site [ion binding]; other site 521674009244 putative dehydratase; Provisional; Region: PRK08211 521674009245 Dehydratase family; Region: ILVD_EDD; cl00340 521674009246 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 521674009247 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 521674009248 PGAP1-like protein; Region: PGAP1; pfam07819 521674009249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674009250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674009251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521674009252 dimerization interface [polypeptide binding]; other site 521674009253 putative DNA binding site [nucleotide binding]; other site 521674009254 putative Zn2+ binding site [ion binding]; other site 521674009255 KWG Leptospira; Region: KWG; pfam07656 521674009256 KWG Leptospira; Region: KWG; pfam07656 521674009257 Pectic acid lyase; Region: Pec_lyase; pfam09492 521674009258 BNR repeat-like domain; Region: BNR_2; pfam13088 521674009259 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 521674009260 Asp-box motif; other site 521674009261 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 521674009262 BNR repeat-like domain; Region: BNR_2; pfam13088 521674009263 Asp-box motif; other site 521674009264 catalytic site [active] 521674009265 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521674009266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674009267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674009268 DNA binding residues [nucleotide binding] 521674009269 Putative zinc-finger; Region: zf-HC2; pfam13490 521674009270 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521674009271 active site 521674009272 metal binding site [ion binding]; metal-binding site 521674009273 hypothetical protein; Provisional; Region: PRK13665 521674009274 arginine decarboxylase; Provisional; Region: PRK05354 521674009275 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 521674009276 dimer interface [polypeptide binding]; other site 521674009277 active site 521674009278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521674009279 catalytic residues [active] 521674009280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 521674009281 putative heme peroxidase; Provisional; Region: PRK12276 521674009282 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 521674009283 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521674009284 NAD binding site [chemical binding]; other site 521674009285 putative substrate binding site 2 [chemical binding]; other site 521674009286 putative substrate binding site 1 [chemical binding]; other site 521674009287 active site 521674009288 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 521674009289 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521674009290 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521674009291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521674009292 catalytic residue [active] 521674009293 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521674009294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674009295 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674009296 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 521674009297 galactarate dehydratase; Region: galactar-dH20; TIGR03248 521674009298 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 521674009299 peptidase T; Region: peptidase-T; TIGR01882 521674009300 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521674009301 metal binding site [ion binding]; metal-binding site 521674009302 dimer interface [polypeptide binding]; other site 521674009303 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521674009304 catalytic residues [active] 521674009305 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521674009306 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 521674009307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 521674009308 dimer interface [polypeptide binding]; other site 521674009309 active site 521674009310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521674009311 catalytic residues [active] 521674009312 substrate binding site [chemical binding]; other site 521674009313 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 521674009314 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 521674009315 hexamer interface [polypeptide binding]; other site 521674009316 ligand binding site [chemical binding]; other site 521674009317 putative active site [active] 521674009318 NAD(P) binding site [chemical binding]; other site 521674009319 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674009320 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521674009321 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521674009322 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 521674009323 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521674009324 Putative zinc-finger; Region: zf-HC2; pfam13490 521674009325 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 521674009326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674009327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674009328 DNA binding residues [nucleotide binding] 521674009329 Rrf2 family protein; Region: rrf2_super; TIGR00738 521674009330 Transcriptional regulator; Region: Rrf2; pfam02082 521674009331 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 521674009332 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 521674009333 heme-binding site [chemical binding]; other site 521674009334 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 521674009335 FAD binding pocket [chemical binding]; other site 521674009336 FAD binding motif [chemical binding]; other site 521674009337 phosphate binding motif [ion binding]; other site 521674009338 beta-alpha-beta structure motif; other site 521674009339 NAD binding pocket [chemical binding]; other site 521674009340 Heme binding pocket [chemical binding]; other site 521674009341 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521674009342 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 521674009343 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674009344 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674009345 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 521674009346 putative metal binding site [ion binding]; other site 521674009347 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674009348 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674009349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009353 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 521674009354 Di-iron ligands [ion binding]; other site 521674009355 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 521674009356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521674009357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521674009358 active site 521674009359 phosphorylation site [posttranslational modification] 521674009360 intermolecular recognition site; other site 521674009361 dimerization interface [polypeptide binding]; other site 521674009362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521674009363 DNA binding site [nucleotide binding] 521674009364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674009365 dimer interface [polypeptide binding]; other site 521674009366 phosphorylation site [posttranslational modification] 521674009367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674009368 ATP binding site [chemical binding]; other site 521674009369 Mg2+ binding site [ion binding]; other site 521674009370 G-X-G motif; other site 521674009371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521674009372 Zn2+ binding site [ion binding]; other site 521674009373 Mg2+ binding site [ion binding]; other site 521674009374 PAS domain; Region: PAS_9; pfam13426 521674009375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521674009376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521674009377 metal binding site [ion binding]; metal-binding site 521674009378 active site 521674009379 I-site; other site 521674009380 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 521674009381 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009382 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 521674009383 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009384 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009385 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009386 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 521674009387 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 521674009388 tetramer interface [polypeptide binding]; other site 521674009389 active site 521674009390 Class I aldolases; Region: Aldolase_Class_I; cl17187 521674009391 transaldolase; Provisional; Region: PRK03903 521674009392 catalytic residue [active] 521674009393 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 521674009394 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 521674009395 Protein of unknown function (DUF420); Region: DUF420; cl00989 521674009396 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 521674009397 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 521674009398 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 521674009399 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 521674009400 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 521674009401 Leucine rich repeat; Region: LRR_8; pfam13855 521674009402 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 521674009403 Leucine-rich repeats; other site 521674009404 Substrate binding site [chemical binding]; other site 521674009405 Scramblase; Region: Scramblase; pfam03803 521674009406 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 521674009407 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 521674009408 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 521674009409 active site 521674009410 ATP binding site [chemical binding]; other site 521674009411 substrate binding site [chemical binding]; other site 521674009412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 521674009413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521674009414 dimer interface [polypeptide binding]; other site 521674009415 phosphorylation site [posttranslational modification] 521674009416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521674009417 ATP binding site [chemical binding]; other site 521674009418 Mg2+ binding site [ion binding]; other site 521674009419 G-X-G motif; other site 521674009420 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 521674009421 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674009422 Trp docking motif [polypeptide binding]; other site 521674009423 active site 521674009424 PQQ-like domain; Region: PQQ_2; pfam13360 521674009425 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 521674009426 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 521674009427 putative active site [active] 521674009428 catalytic triad [active] 521674009429 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 521674009430 NADH dehydrogenase subunit B; Validated; Region: PRK06411 521674009431 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 521674009432 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 521674009433 NADH dehydrogenase subunit D; Validated; Region: PRK06075 521674009434 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 521674009435 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 521674009436 putative dimer interface [polypeptide binding]; other site 521674009437 [2Fe-2S] cluster binding site [ion binding]; other site 521674009438 aconitate hydratase; Validated; Region: PRK09277 521674009439 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 521674009440 SLBB domain; Region: SLBB; pfam10531 521674009441 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 521674009442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521674009443 catalytic loop [active] 521674009444 iron binding site [ion binding]; other site 521674009445 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 521674009446 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 521674009447 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 521674009448 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 521674009449 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 521674009450 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 521674009451 4Fe-4S binding domain; Region: Fer4; pfam00037 521674009452 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 521674009453 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 521674009454 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 521674009455 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 521674009456 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 521674009457 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674009458 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 521674009459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674009460 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 521674009461 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 521674009462 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 521674009463 HDOD domain; Region: HDOD; pfam08668 521674009464 HDOD domain; Region: HDOD; pfam08668 521674009465 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 521674009466 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 521674009467 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674009468 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521674009469 putative catalytic site [active] 521674009470 putative metal binding site [ion binding]; other site 521674009471 putative phosphate binding site [ion binding]; other site 521674009472 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 521674009473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521674009474 DXD motif; other site 521674009475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521674009476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674009477 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521674009478 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 521674009479 NodB motif; other site 521674009480 putative active site [active] 521674009481 putative catalytic site [active] 521674009482 putative Zn binding site [ion binding]; other site 521674009483 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 521674009484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674009485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 521674009486 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 521674009487 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521674009488 active site 521674009489 AMP binding site [chemical binding]; other site 521674009490 acyl-activating enzyme (AAE) consensus motif; other site 521674009491 CoA binding site [chemical binding]; other site 521674009492 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 521674009493 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 521674009494 putative ADP-binding pocket [chemical binding]; other site 521674009495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 521674009496 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 521674009497 multifunctional aminopeptidase A; Provisional; Region: PRK00913 521674009498 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 521674009499 interface (dimer of trimers) [polypeptide binding]; other site 521674009500 Substrate-binding/catalytic site; other site 521674009501 Zn-binding sites [ion binding]; other site 521674009502 PilZ domain; Region: PilZ; pfam07238 521674009503 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 521674009504 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 521674009505 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 521674009506 NAD binding site [chemical binding]; other site 521674009507 homotetramer interface [polypeptide binding]; other site 521674009508 homodimer interface [polypeptide binding]; other site 521674009509 substrate binding site [chemical binding]; other site 521674009510 active site 521674009511 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 521674009512 active site 521674009513 8-oxo-dGMP binding site [chemical binding]; other site 521674009514 nudix motif; other site 521674009515 metal binding site [ion binding]; metal-binding site 521674009516 Predicted transcriptional regulator [Transcription]; Region: COG2378 521674009517 HTH domain; Region: HTH_11; pfam08279 521674009518 WYL domain; Region: WYL; pfam13280 521674009519 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674009520 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674009521 phosphopeptide binding site; other site 521674009522 Protein kinase domain; Region: Pkinase; pfam00069 521674009523 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674009524 active site 521674009525 ATP binding site [chemical binding]; other site 521674009526 substrate binding site [chemical binding]; other site 521674009527 activation loop (A-loop); other site 521674009528 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 521674009529 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521674009530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674009531 motif II; other site 521674009532 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521674009533 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 521674009534 PA/protease or protease-like domain interface [polypeptide binding]; other site 521674009535 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 521674009536 Peptidase family M28; Region: Peptidase_M28; pfam04389 521674009537 metal binding site [ion binding]; metal-binding site 521674009538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674009539 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 521674009540 tartrate dehydrogenase; Region: TTC; TIGR02089 521674009541 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 521674009542 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521674009543 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 521674009544 putative dimerization interface [polypeptide binding]; other site 521674009545 putative ligand binding site [chemical binding]; other site 521674009546 Helix-turn-helix domain; Region: HTH_18; pfam12833 521674009547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521674009548 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009549 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 521674009550 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 521674009551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674009552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674009553 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674009554 Sulfatase; Region: Sulfatase; pfam00884 521674009555 Uncharacterized conserved protein [Function unknown]; Region: COG5361 521674009556 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 521674009557 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 521674009558 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 521674009559 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674009560 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674009561 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521674009562 nucleotide binding site [chemical binding]; other site 521674009563 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521674009564 SBD interface [polypeptide binding]; other site 521674009565 DinB superfamily; Region: DinB_2; pfam12867 521674009566 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009567 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009568 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 521674009569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521674009570 active site 521674009571 Fic family protein [Function unknown]; Region: COG3177 521674009572 Fic/DOC family; Region: Fic; pfam02661 521674009573 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 521674009574 Family description; Region: VCBS; pfam13517 521674009575 Family description; Region: VCBS; pfam13517 521674009576 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521674009577 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 521674009578 putative RNA binding site [nucleotide binding]; other site 521674009579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674009580 S-adenosylmethionine binding site [chemical binding]; other site 521674009581 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 521674009582 sulfite oxidase; Provisional; Region: PLN00177 521674009583 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 521674009584 Moco binding site; other site 521674009585 metal coordination site [ion binding]; other site 521674009586 dimerization interface [polypeptide binding]; other site 521674009587 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 521674009588 active site 521674009589 catalytic residues [active] 521674009590 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009591 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 521674009592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674009593 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521674009594 active site 521674009595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674009596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674009597 binding surface 521674009598 TPR motif; other site 521674009599 AhpC/TSA family; Region: AhpC-TSA; pfam00578 521674009600 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674009601 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674009602 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674009603 catalytic residues [active] 521674009604 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521674009605 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674009606 catalytic residues [active] 521674009607 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674009608 Competence-damaged protein; Region: CinA; pfam02464 521674009609 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674009610 Sulfatase; Region: Sulfatase; pfam00884 521674009611 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 521674009612 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 521674009613 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521674009614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674009615 Walker A motif; other site 521674009616 ATP binding site [chemical binding]; other site 521674009617 Walker B motif; other site 521674009618 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521674009619 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 521674009620 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 521674009621 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521674009622 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521674009623 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 521674009624 Predicted integral membrane protein [Function unknown]; Region: COG5652 521674009625 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521674009626 PilZ domain; Region: PilZ; pfam07238 521674009627 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 521674009628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674009629 Abortive infection C-terminus; Region: Abi_C; pfam14355 521674009630 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674009631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521674009632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 521674009633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521674009634 NAD(P) binding site [chemical binding]; other site 521674009635 active site 521674009636 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 521674009637 Helix-turn-helix domain; Region: HTH_31; pfam13560 521674009638 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 521674009639 Pathogenicity locus; Region: Cdd1; pfam11731 521674009640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674009641 Coenzyme A binding pocket [chemical binding]; other site 521674009642 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674009643 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674009644 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674009645 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 521674009646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521674009647 putative active site [active] 521674009648 putative metal binding site [ion binding]; other site 521674009649 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 521674009650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674009651 S-adenosylmethionine binding site [chemical binding]; other site 521674009652 RNA methyltransferase, RsmE family; Region: TIGR00046 521674009653 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 521674009654 TPR repeat; Region: TPR_11; pfam13414 521674009655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674009656 TPR motif; other site 521674009657 binding surface 521674009658 TPR repeat; Region: TPR_11; pfam13414 521674009659 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 521674009660 putative acyl-acceptor binding pocket; other site 521674009661 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 521674009662 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 521674009663 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 521674009664 active site 521674009665 catalytic site [active] 521674009666 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 521674009667 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 521674009668 heme-binding residues [chemical binding]; other site 521674009669 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 521674009670 molybdopterin cofactor binding site; other site 521674009671 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 521674009672 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 521674009673 4Fe-4S binding domain; Region: Fer4_2; pfam12797 521674009674 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 521674009675 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 521674009676 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 521674009677 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 521674009678 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 521674009679 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 521674009680 Cu(I) binding site [ion binding]; other site 521674009681 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 521674009682 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 521674009683 Cytochrome c; Region: Cytochrom_C; pfam00034 521674009684 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 521674009685 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 521674009686 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 521674009687 Subunit I/III interface [polypeptide binding]; other site 521674009688 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 521674009689 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 521674009690 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 521674009691 Subunit I/III interface [polypeptide binding]; other site 521674009692 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 521674009693 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521674009694 active site 521674009695 dimer interface [polypeptide binding]; other site 521674009696 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521674009697 dimer interface [polypeptide binding]; other site 521674009698 active site 521674009699 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 521674009700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521674009701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674009702 homodimer interface [polypeptide binding]; other site 521674009703 catalytic residue [active] 521674009704 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 521674009705 FAD binding site [chemical binding]; other site 521674009706 Dynamin family; Region: Dynamin_N; pfam00350 521674009707 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 521674009708 G1 box; other site 521674009709 GTP/Mg2+ binding site [chemical binding]; other site 521674009710 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 521674009711 G3 box; other site 521674009712 Switch II region; other site 521674009713 GTP/Mg2+ binding site [chemical binding]; other site 521674009714 G4 box; other site 521674009715 G5 box; other site 521674009716 large tegument protein UL36; Provisional; Region: PHA03247 521674009717 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521674009718 Sulfatase; Region: Sulfatase; pfam00884 521674009719 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674009720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674009721 active site 521674009722 ATP binding site [chemical binding]; other site 521674009723 substrate binding site [chemical binding]; other site 521674009724 activation loop (A-loop); other site 521674009725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674009726 S-adenosylmethionine binding site [chemical binding]; other site 521674009727 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674009728 metal ion-dependent adhesion site (MIDAS); other site 521674009729 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674009730 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674009731 metal ion-dependent adhesion site (MIDAS); other site 521674009732 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 521674009733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521674009734 Walker A/P-loop; other site 521674009735 ATP binding site [chemical binding]; other site 521674009736 ABC transporter; Region: ABC_tran; pfam00005 521674009737 Q-loop/lid; other site 521674009738 ABC transporter signature motif; other site 521674009739 Walker B; other site 521674009740 D-loop; other site 521674009741 H-loop/switch region; other site 521674009742 NHL repeat; Region: NHL; pfam01436 521674009743 Uncharacterized conserved protein [Function unknown]; Region: COG3391 521674009744 NHL repeat; Region: NHL; pfam01436 521674009745 NHL repeat; Region: NHL; pfam01436 521674009746 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521674009747 PQQ-like domain; Region: PQQ_2; pfam13360 521674009748 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674009749 Trp docking motif [polypeptide binding]; other site 521674009750 active site 521674009751 Predicted transcriptional regulator [Transcription]; Region: COG1959 521674009752 Transcriptional regulator; Region: Rrf2; pfam02082 521674009753 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009754 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009755 MoxR-like ATPases [General function prediction only]; Region: COG0714 521674009756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521674009757 Walker A motif; other site 521674009758 ATP binding site [chemical binding]; other site 521674009759 Walker B motif; other site 521674009760 arginine finger; other site 521674009761 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 521674009762 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521674009763 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521674009764 protein binding site [polypeptide binding]; other site 521674009765 Glucose dehydrogenase; Region: glucose_DH; cd08230 521674009766 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521674009767 NADP binding site [chemical binding]; other site 521674009768 catalytic Zn binding site [ion binding]; other site 521674009769 structural Zn binding site [ion binding]; other site 521674009770 dimer interface [polypeptide binding]; other site 521674009771 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 521674009772 MraW methylase family; Region: Methyltransf_5; cl17771 521674009773 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 521674009774 Uncharacterized conserved protein [Function unknown]; Region: COG5135 521674009775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674009776 active site 521674009777 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 521674009778 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521674009779 Ligand Binding Site [chemical binding]; other site 521674009780 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521674009781 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 521674009782 putative RNA binding site [nucleotide binding]; other site 521674009783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674009784 S-adenosylmethionine binding site [chemical binding]; other site 521674009785 Domain of unknown function DUF87; Region: DUF87; pfam01935 521674009786 HerA helicase [Replication, recombination, and repair]; Region: COG0433 521674009787 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 521674009788 active site 521674009789 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674009790 Trp docking motif [polypeptide binding]; other site 521674009791 PQQ-like domain; Region: PQQ_2; pfam13360 521674009792 active site 521674009793 Protein of unknown function, DUF486; Region: DUF486; cl01236 521674009794 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674009795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674009796 active site 521674009797 ATP binding site [chemical binding]; other site 521674009798 substrate binding site [chemical binding]; other site 521674009799 activation loop (A-loop); other site 521674009800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521674009801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521674009802 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 521674009803 Walker A/P-loop; other site 521674009804 ATP binding site [chemical binding]; other site 521674009805 Q-loop/lid; other site 521674009806 ABC transporter signature motif; other site 521674009807 Walker B; other site 521674009808 D-loop; other site 521674009809 H-loop/switch region; other site 521674009810 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521674009811 active site residue [active] 521674009812 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 521674009813 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521674009814 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521674009815 active site 521674009816 ATP binding site [chemical binding]; other site 521674009817 substrate binding site [chemical binding]; other site 521674009818 activation loop (A-loop); other site 521674009819 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521674009820 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009821 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674009822 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 521674009823 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 521674009824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 521674009825 dimer interface [polypeptide binding]; other site 521674009826 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521674009827 metal binding site [ion binding]; metal-binding site 521674009828 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521674009829 Ligand binding site; other site 521674009830 Putative Catalytic site; other site 521674009831 DXD motif; other site 521674009832 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521674009833 Domain of unknown function DUF87; Region: DUF87; pfam01935 521674009834 HerA helicase [Replication, recombination, and repair]; Region: COG0433 521674009835 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 521674009836 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 521674009837 MutS domain I; Region: MutS_I; pfam01624 521674009838 MutS domain II; Region: MutS_II; pfam05188 521674009839 MutS domain III; Region: MutS_III; pfam05192 521674009840 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 521674009841 Walker A/P-loop; other site 521674009842 ATP binding site [chemical binding]; other site 521674009843 Q-loop/lid; other site 521674009844 ABC transporter signature motif; other site 521674009845 Walker B; other site 521674009846 D-loop; other site 521674009847 H-loop/switch region; other site 521674009848 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 521674009849 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009850 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521674009851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521674009852 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 521674009853 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 521674009854 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 521674009855 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 521674009856 flagellar motor switch protein FliN; Region: fliN; TIGR02480 521674009857 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 521674009858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674009859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521674009860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521674009861 non-specific DNA binding site [nucleotide binding]; other site 521674009862 salt bridge; other site 521674009863 sequence-specific DNA binding site [nucleotide binding]; other site 521674009864 PBP superfamily domain; Region: PBP_like; pfam12727 521674009865 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009866 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 521674009867 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521674009868 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521674009869 ligand binding site [chemical binding]; other site 521674009870 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 521674009871 AhpC/TSA family; Region: AhpC-TSA; pfam00578 521674009872 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 521674009873 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 521674009874 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 521674009875 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009876 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674009877 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 521674009878 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 521674009879 Domain of unknown function DUF21; Region: DUF21; pfam01595 521674009880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521674009881 Transporter associated domain; Region: CorC_HlyC; smart01091 521674009882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674009883 S-adenosylmethionine binding site [chemical binding]; other site 521674009884 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 521674009885 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521674009886 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 521674009887 ATP cone domain; Region: ATP-cone; pfam03477 521674009888 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521674009889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521674009890 DNA binding residues [nucleotide binding] 521674009891 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 521674009892 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 521674009893 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 521674009894 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674009895 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 521674009896 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521674009897 homodimer interface [polypeptide binding]; other site 521674009898 substrate-cofactor binding pocket; other site 521674009899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521674009900 catalytic residue [active] 521674009901 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 521674009902 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674009903 catalytic residues [active] 521674009904 Uncharacterized conserved protein [Function unknown]; Region: COG3391 521674009905 NHL repeat; Region: NHL; pfam01436 521674009906 NHL repeat; Region: NHL; pfam01436 521674009907 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 521674009908 FAD binding domain; Region: FAD_binding_4; pfam01565 521674009909 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 521674009910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 521674009911 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 521674009912 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 521674009913 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 521674009914 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 521674009915 PQQ-like domain; Region: PQQ_2; pfam13360 521674009916 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 521674009917 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 521674009918 tetramerization interface [polypeptide binding]; other site 521674009919 active site 521674009920 Methane oxygenase PmoA; Region: PmoA; pfam14100 521674009921 Cupin domain; Region: Cupin_2; pfam07883 521674009922 O-Antigen ligase; Region: Wzy_C; pfam04932 521674009923 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 521674009924 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 521674009925 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 521674009926 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521674009927 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 521674009928 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 521674009929 SLBB domain; Region: SLBB; pfam10531 521674009930 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521674009931 GIY-YIG motif/motif A; other site 521674009932 active site 521674009933 catalytic site [active] 521674009934 putative DNA binding site [nucleotide binding]; other site 521674009935 metal binding site [ion binding]; metal-binding site 521674009936 UvrB/uvrC motif; Region: UVR; pfam02151 521674009937 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521674009938 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521674009939 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521674009940 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 521674009941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521674009942 motif II; other site 521674009943 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521674009944 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521674009945 acetyl-CoA synthetase; Provisional; Region: PRK00174 521674009946 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 521674009947 active site 521674009948 CoA binding site [chemical binding]; other site 521674009949 acyl-activating enzyme (AAE) consensus motif; other site 521674009950 AMP binding site [chemical binding]; other site 521674009951 acetate binding site [chemical binding]; other site 521674009952 TadE-like protein; Region: TadE; pfam07811 521674009953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521674009954 metal ion-dependent adhesion site (MIDAS); other site 521674009955 TadE-like protein; Region: TadE; pfam07811 521674009956 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 521674009957 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 521674009958 active site 521674009959 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521674009960 HlyD family secretion protein; Region: HlyD_3; pfam13437 521674009961 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 521674009962 amidase catalytic site [active] 521674009963 Zn binding residues [ion binding]; other site 521674009964 substrate binding site [chemical binding]; other site 521674009965 Predicted esterase [General function prediction only]; Region: COG0400 521674009966 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 521674009967 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 521674009968 G1 box; other site 521674009969 GTP/Mg2+ binding site [chemical binding]; other site 521674009970 G2 box; other site 521674009971 Switch I region; other site 521674009972 G3 box; other site 521674009973 Switch II region; other site 521674009974 G4 box; other site 521674009975 G5 box; other site 521674009976 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521674009977 rRNA binding site [nucleotide binding]; other site 521674009978 predicted 30S ribosome binding site; other site 521674009979 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 521674009980 active site 521674009981 RNA/DNA hybrid binding site [nucleotide binding]; other site 521674009982 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521674009983 active site 521674009984 catalytic triad [active] 521674009985 oxyanion hole [active] 521674009986 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 521674009987 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 521674009988 Sulfatase; Region: Sulfatase; cl17466 521674009989 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 521674009990 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 521674009991 Predicted integral membrane protein [Function unknown]; Region: COG5615 521674009992 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521674009993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521674009994 RNA binding surface [nucleotide binding]; other site 521674009995 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 521674009996 active site 521674009997 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 521674009998 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 521674009999 FAD binding pocket [chemical binding]; other site 521674010000 FAD binding motif [chemical binding]; other site 521674010001 phosphate binding motif [ion binding]; other site 521674010002 beta-alpha-beta structure motif; other site 521674010003 NAD binding pocket [chemical binding]; other site 521674010004 Iron coordination center [ion binding]; other site 521674010005 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 521674010006 GTP1/OBG; Region: GTP1_OBG; pfam01018 521674010007 Obg GTPase; Region: Obg; cd01898 521674010008 G1 box; other site 521674010009 GTP/Mg2+ binding site [chemical binding]; other site 521674010010 Switch I region; other site 521674010011 G2 box; other site 521674010012 G3 box; other site 521674010013 Switch II region; other site 521674010014 G4 box; other site 521674010015 G5 box; other site 521674010016 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521674010017 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521674010018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521674010019 active site 521674010020 Cupin domain; Region: Cupin_2; cl17218 521674010021 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674010022 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 521674010023 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 521674010024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521674010025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 521674010026 phosphorylation site [posttranslational modification] 521674010027 intermolecular recognition site; other site 521674010028 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 521674010029 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 521674010030 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 521674010031 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 521674010032 putative ADP-binding pocket [chemical binding]; other site 521674010033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674010034 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 521674010035 argininosuccinate synthase; Provisional; Region: PRK13820 521674010036 ANP binding site [chemical binding]; other site 521674010037 Substrate Binding Site II [chemical binding]; other site 521674010038 Substrate Binding Site I [chemical binding]; other site 521674010039 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521674010040 Protein of unknown function DUF58; Region: DUF58; pfam01882 521674010041 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521674010042 Hemin uptake protein hemP; Region: hemP; pfam10636 521674010043 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 521674010044 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 521674010045 NAD(P) binding site [chemical binding]; other site 521674010046 homodimer interface [polypeptide binding]; other site 521674010047 substrate binding site [chemical binding]; other site 521674010048 active site 521674010049 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 521674010050 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521674010051 SmpB-tmRNA interface; other site 521674010052 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 521674010053 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 521674010054 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521674010055 P loop; other site 521674010056 GTP binding site [chemical binding]; other site 521674010057 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521674010058 active site 521674010059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674010060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 521674010061 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 521674010062 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674010063 TspO/MBR family; Region: TspO_MBR; pfam03073 521674010064 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521674010065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521674010066 S-adenosylmethionine binding site [chemical binding]; other site 521674010067 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 521674010068 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 521674010069 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 521674010070 Walker A motif; other site 521674010071 ATP binding site [chemical binding]; other site 521674010072 Walker B motif; other site 521674010073 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674010074 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674010075 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 521674010076 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 521674010077 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 521674010078 oligomer interface [polypeptide binding]; other site 521674010079 metal binding site [ion binding]; metal-binding site 521674010080 metal binding site [ion binding]; metal-binding site 521674010081 Cl binding site [ion binding]; other site 521674010082 aspartate ring; other site 521674010083 basic sphincter; other site 521674010084 putative hydrophobic gate; other site 521674010085 periplasmic entrance; other site 521674010086 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 521674010087 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 521674010088 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 521674010089 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 521674010090 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 521674010091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674010092 binding surface 521674010093 TPR motif; other site 521674010094 Proline dehydrogenase; Region: Pro_dh; cl03282 521674010095 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 521674010096 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 521674010097 Glutamate binding site [chemical binding]; other site 521674010098 homodimer interface [polypeptide binding]; other site 521674010099 NAD binding site [chemical binding]; other site 521674010100 catalytic residues [active] 521674010101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521674010102 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521674010103 SEC-C motif; Region: SEC-C; pfam02810 521674010104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674010105 TPR motif; other site 521674010106 binding surface 521674010107 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 521674010108 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 521674010109 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521674010110 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521674010111 motif 1; other site 521674010112 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521674010113 active site 521674010114 motif 2; other site 521674010115 motif 3; other site 521674010116 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 521674010117 anticodon binding site; other site 521674010118 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 521674010119 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 521674010120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674010121 TPR motif; other site 521674010122 binding surface 521674010123 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 521674010124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521674010125 binding surface 521674010126 TPR motif; other site 521674010127 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 521674010128 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521674010129 catalytic triad [active] 521674010130 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 521674010131 FAD dependent oxidoreductase; Region: DAO; pfam01266 521674010132 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 521674010133 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 521674010134 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 521674010135 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521674010136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521674010137 Coenzyme A binding pocket [chemical binding]; other site 521674010138 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521674010139 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521674010140 phosphopeptide binding site; other site 521674010141 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674010142 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521674010143 anti sigma factor interaction site; other site 521674010144 regulatory phosphorylation site [posttranslational modification]; other site 521674010145 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521674010146 putative active site pocket [active] 521674010147 dimerization interface [polypeptide binding]; other site 521674010148 putative catalytic residue [active] 521674010149 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 521674010150 putative active site pocket [active] 521674010151 dimerization interface [polypeptide binding]; other site 521674010152 putative catalytic residue [active] 521674010153 HEAT repeats; Region: HEAT_2; pfam13646 521674010154 HEAT repeats; Region: HEAT_2; pfam13646 521674010155 acetylornithine deacetylase; Provisional; Region: PRK07522 521674010156 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 521674010157 metal binding site [ion binding]; metal-binding site 521674010158 putative dimer interface [polypeptide binding]; other site 521674010159 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521674010160 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521674010161 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 521674010162 aromatic arch; other site 521674010163 DCoH dimer interaction site [polypeptide binding]; other site 521674010164 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 521674010165 DCoH tetramer interaction site [polypeptide binding]; other site 521674010166 substrate binding site [chemical binding]; other site 521674010167 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674010168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 521674010169 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 521674010170 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 521674010171 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521674010172 Trp docking motif [polypeptide binding]; other site 521674010173 PQQ-like domain; Region: PQQ_2; pfam13360 521674010174 active site 521674010175 RDD family; Region: RDD; pfam06271 521674010176 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 521674010177 HEAT repeats; Region: HEAT_2; pfam13646 521674010178 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521674010179 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 521674010180 active site 521674010181 Phage terminase, small subunit; Region: Terminase_4; pfam05119 521674010182 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 521674010183 Phage-related protein [Function unknown]; Region: COG4695; cl01923 521674010184 Phage portal protein; Region: Phage_portal; pfam04860 521674010185 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 521674010186 oligomer interface [polypeptide binding]; other site 521674010187 active site residues [active] 521674010188 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 521674010189 Phage capsid family; Region: Phage_capsid; pfam05065 521674010190 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 521674010191 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 521674010192 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 521674010193 oligomerization interface [polypeptide binding]; other site 521674010194 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 521674010195 tape measure domain; Region: tape_meas_nterm; TIGR02675 521674010196 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 521674010197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521674010198 active site 521674010199 catalytic residues [active] 521674010200 DNA binding site [nucleotide binding] 521674010201 Int/Topo IB signature motif; other site 521674010202 Bacterial PH domain; Region: DUF304; cl01348 521674010203 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 521674010204 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521674010205 active site 521674010206 catalytic residues [active] 521674010207 Int/Topo IB signature motif; other site 521674010208 DNA binding site [nucleotide binding] 521674010209 Global regulator protein family; Region: CsrA; pfam02599 521674010210 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 521674010211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 521674010212 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 521674010213 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 521674010214 ParB-like nuclease domain; Region: ParB; smart00470 521674010215 CRISPR/Cas system-associated protein Csx14; Region: Csx14_I-U; cl14805