-- dump date   	20140619_234452
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
891974000001	Transposase IS200 like; Region: Y1_Tnp; pfam01797
891974000002	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
891974000003	CcdB protein; Region: CcdB; pfam01845
891974000004	SprT-like family; Region: SprT-like; pfam10263
891974000005	ParA-like protein; Provisional; Region: PHA02518
891974000006	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
891974000007	P-loop; other site
891974000008	Magnesium ion binding site [ion binding]; other site
891974000009	Staphylococcal nuclease homologues; Region: SNc; smart00318
891974000010	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
891974000011	Catalytic site; other site
891974000012	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
891974000013	VirB7 interaction site; other site
891974000014	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
891974000015	VirB8 protein; Region: VirB8; pfam04335
891974000016	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
891974000017	Type IV secretion system proteins; Region: T4SS; pfam07996
891974000018	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
891974000019	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
891974000020	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
891974000021	TrbC/VIRB2 family; Region: TrbC; pfam04956
891974000022	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974000023	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974000024	catalytic residue [active]
891974000025	Domain of unknown function DUF87; Region: DUF87; cl19135
891974000026	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
891974000027	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
891974000028	DNA binding residues [nucleotide binding]
891974000029	dimerization interface [polypeptide binding]; other site
891974000030	Replication initiator protein A; Region: RPA; cl19398
891974000031	classical (c) SDRs; Region: SDR_c; cd05233
891974000032	active site
891974000033	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
891974000034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974000035	Transposase; Region: HTH_Tnp_1; cl17663
891974000036	Integrase core domain; Region: rve; pfam00665
891974000037	Integrase core domain; Region: rve_3; pfam13683
891974000038	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
891974000039	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
891974000040	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
891974000041	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974000042	DNA binding site [nucleotide binding]
891974000043	active site
891974000044	Int/Topo IB signature motif; other site
891974000045	ParB-like nuclease domain; Region: ParB; smart00470
891974000046	ParB family; Region: ParB; pfam08775
891974000047	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
891974000048	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
891974000049	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974000050	P-loop; other site
891974000051	Magnesium ion binding site [ion binding]; other site
891974000052	DNA methylase; Region: N6_N4_Mtase; cl17433
891974000053	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
891974000054	Antirestriction protein; Region: Antirestrict; pfam03230
891974000055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974000056	Transposase; Region: HTH_Tnp_1; cl17663
891974000057	Integrase core domain; Region: rve; pfam00665
891974000058	Integrase core domain; Region: rve_3; pfam13683
891974000059	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
891974000060	active site
891974000061	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
891974000062	nudix motif; other site
891974000063	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974000064	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974000065	catalytic residue [active]
891974000066	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974000067	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
891974000068	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974000069	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
891974000070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974000071	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974000072	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
891974000073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000074	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
891974000075	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
891974000076	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
891974000077	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974000078	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
891974000079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000080	ABC transporter signature motif; other site
891974000081	Walker B; other site
891974000082	D-loop; other site
891974000083	H-loop/switch region; other site
891974000084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974000085	dimer interface [polypeptide binding]; other site
891974000086	conserved gate region; other site
891974000087	putative PBP binding loops; other site
891974000088	ABC-ATPase subunit interface; other site
891974000089	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974000090	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974000091	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974000092	putative active site [active]
891974000093	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974000094	IncFII RepA protein family; Region: IncFII_repA; cl11495
891974000095	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
891974000096	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
891974000097	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
891974000098	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
891974000099	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
891974000100	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
891974000101	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
891974000102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974000103	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
891974000104	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974000105	non-specific DNA binding site [nucleotide binding]; other site
891974000106	salt bridge; other site
891974000107	sequence-specific DNA binding site [nucleotide binding]; other site
891974000108	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
891974000109	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
891974000110	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
891974000111	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
891974000112	dimer interface [polypeptide binding]; other site
891974000113	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
891974000114	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974000115	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974000116	dimerization interface [polypeptide binding]; other site
891974000117	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
891974000118	amidohydrolase; Region: amidohydrolases; TIGR01891
891974000119	putative metal binding site [ion binding]; other site
891974000120	dimer interface [polypeptide binding]; other site
891974000121	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
891974000122	amidohydrolase; Region: amidohydrolases; TIGR01891
891974000123	putative metal binding site [ion binding]; other site
891974000124	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974000125	AbgT putative transporter family; Region: ABG_transport; cl17431
891974000126	AbgT putative transporter family; Region: ABG_transport; cl17431
891974000127	benzoate transport; Region: 2A0115; TIGR00895
891974000128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000129	putative substrate translocation pore; other site
891974000130	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
891974000131	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974000132	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974000133	Cytochrome c; Region: Cytochrom_C; pfam00034
891974000134	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974000135	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974000136	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
891974000137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974000138	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974000139	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974000140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974000141	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
891974000142	microcin B17 transporter; Reviewed; Region: PRK11098
891974000143	DAK2 domain; Region: Dak2; cl03685
891974000144	Dak1 domain; Region: Dak1; cl10557
891974000145	DAK2 domain; Region: Dak2; cl03685
891974000146	Dak1 domain; Region: Dak1; cl10557
891974000147	PQQ-like domain; Region: PQQ_2; pfam13360
891974000148	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
891974000149	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974000150	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974000151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000153	Cupin; Region: Cupin_6; pfam12852
891974000154	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974000155	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974000156	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
891974000157	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974000158	dimer interface [polypeptide binding]; other site
891974000159	putative CheW interface [polypeptide binding]; other site
891974000160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974000161	PAS fold; Region: PAS_3; pfam08447
891974000162	putative active site [active]
891974000163	heme pocket [chemical binding]; other site
891974000164	fructuronate transporter; Provisional; Region: PRK10034; cl15264
891974000165	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
891974000166	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
891974000167	PhoU domain; Region: PhoU; pfam01895
891974000168	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
891974000169	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
891974000170	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
891974000171	TOBE domain; Region: TOBE_2; pfam08402
891974000172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000173	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
891974000174	Walker A/P-loop; other site
891974000175	ATP binding site [chemical binding]; other site
891974000176	Q-loop/lid; other site
891974000177	ABC transporter signature motif; other site
891974000178	Walker B; other site
891974000179	D-loop; other site
891974000180	H-loop/switch region; other site
891974000181	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
891974000182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974000183	dimer interface [polypeptide binding]; other site
891974000184	conserved gate region; other site
891974000185	putative PBP binding loops; other site
891974000186	ABC-ATPase subunit interface; other site
891974000187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974000188	dimer interface [polypeptide binding]; other site
891974000189	ABC-ATPase subunit interface; other site
891974000190	putative PBP binding loops; other site
891974000191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974000192	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
891974000193	Sulfatase; Region: Sulfatase; cl19157
891974000194	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
891974000195	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
891974000196	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
891974000197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974000198	DNA-binding site [nucleotide binding]; DNA binding site
891974000199	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
891974000200	UTRA domain; Region: UTRA; cl17743
891974000201	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
891974000202	Chorismate lyase; Region: Chor_lyase; cl01230
891974000203	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
891974000204	putative active site [active]
891974000205	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
891974000206	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
891974000207	putative acyl-acceptor binding pocket; other site
891974000208	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
891974000209	putative active site [active]
891974000210	trimer interface [polypeptide binding]; other site
891974000211	putative active site [active]
891974000212	Zn binding site [ion binding]; other site
891974000213	LexA repressor; Validated; Region: PRK00215
891974000214	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
891974000215	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
891974000216	Catalytic site [active]
891974000217	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974000218	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974000219	CsbD-like; Region: CsbD; cl17424
891974000220	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
891974000221	metal binding site 2 [ion binding]; metal-binding site
891974000222	putative DNA binding helix; other site
891974000223	metal binding site 1 [ion binding]; metal-binding site
891974000224	dimer interface [polypeptide binding]; other site
891974000225	structural Zn2+ binding site [ion binding]; other site
891974000226	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
891974000227	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
891974000228	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
891974000229	FMN binding site [chemical binding]; other site
891974000230	active site
891974000231	catalytic residues [active]
891974000232	substrate binding site [chemical binding]; other site
891974000233	phage shock protein G; Reviewed; Region: pspG; PRK09459
891974000234	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974000235	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974000236	NAD(P) binding site [chemical binding]; other site
891974000237	replicative DNA helicase; Provisional; Region: PRK08006
891974000238	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
891974000239	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
891974000240	Walker A motif; other site
891974000241	ATP binding site [chemical binding]; other site
891974000242	Walker B motif; other site
891974000243	DNA binding loops [nucleotide binding]
891974000244	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
891974000245	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
891974000246	putative DNA binding site [nucleotide binding]; other site
891974000247	putative Zn2+ binding site [ion binding]; other site
891974000248	Uncharacterized conserved protein [Function unknown]; Region: COG1284
891974000249	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
891974000250	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
891974000251	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
891974000252	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974000253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974000254	homodimer interface [polypeptide binding]; other site
891974000255	catalytic residue [active]
891974000256	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
891974000257	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
891974000258	tetramer interface [polypeptide binding]; other site
891974000259	heme binding pocket [chemical binding]; other site
891974000260	Uncharacterized conserved protein [Function unknown]; Region: COG0432
891974000261	YjbR; Region: YjbR; cl15265
891974000262	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
891974000263	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
891974000264	putative substrate binding site [chemical binding]; other site
891974000265	catalytic Zn binding site [ion binding]; other site
891974000266	structural Zn binding site [ion binding]; other site
891974000267	dimer interface [polypeptide binding]; other site
891974000268	putative NAD(P) binding site [chemical binding]; other site
891974000269	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
891974000270	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
891974000271	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
891974000272	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
891974000273	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
891974000274	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
891974000275	dimer interface [polypeptide binding]; other site
891974000276	ssDNA binding site [nucleotide binding]; other site
891974000277	tetramer (dimer of dimers) interface [polypeptide binding]; other site
891974000278	putative single-stranded DNA-binding protein; Region: PHA01740
891974000279	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
891974000280	catalytic triad [active]
891974000281	conserved cis-peptide bond; other site
891974000282	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
891974000283	Helix-turn-helix domain; Region: HTH_18; pfam12833
891974000284	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
891974000285	EamA-like transporter family; Region: EamA; pfam00892
891974000286	Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250
891974000287	Transposase; Region: HTH_Tnp_1; pfam01527
891974000288	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974000289	Integrase core domain; Region: rve; pfam00665
891974000290	Integrase core domain; Region: rve_3; pfam13683
891974000291	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
891974000292	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
891974000293	purine monophosphate binding site [chemical binding]; other site
891974000294	dimer interface [polypeptide binding]; other site
891974000295	putative catalytic residues [active]
891974000296	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
891974000297	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
891974000298	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
891974000299	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
891974000300	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
891974000301	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
891974000302	histone-like DNA-binding protein HU; Region: HU; cd13831
891974000303	dimer interface [polypeptide binding]; other site
891974000304	DNA binding site [nucleotide binding]
891974000305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
891974000306	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
891974000307	Active_site [active]
891974000308	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
891974000309	substrate binding site [chemical binding]; other site
891974000310	active site
891974000311	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
891974000312	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
891974000313	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
891974000314	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
891974000315	putative NADH binding site [chemical binding]; other site
891974000316	putative active site [active]
891974000317	nudix motif; other site
891974000318	putative metal binding site [ion binding]; other site
891974000319	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478
891974000320	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478
891974000321	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
891974000322	ThiC-associated domain; Region: ThiC-associated; pfam13667
891974000323	ThiC family; Region: ThiC; pfam01964
891974000324	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
891974000325	thiamine phosphate binding site [chemical binding]; other site
891974000326	active site
891974000327	pyrophosphate binding site [ion binding]; other site
891974000328	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
891974000329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974000330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974000331	homodimer interface [polypeptide binding]; other site
891974000332	catalytic residue [active]
891974000333	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974000334	DNA-binding site [nucleotide binding]; DNA binding site
891974000335	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
891974000336	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
891974000337	beta and beta' interface [polypeptide binding]; other site
891974000338	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
891974000339	beta' and sigma factor interface [polypeptide binding]; other site
891974000340	Zn-binding [ion binding]; other site
891974000341	active site region [active]
891974000342	catalytic site [active]
891974000343	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
891974000344	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
891974000345	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
891974000346	DNA binding site [nucleotide binding]
891974000347	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
891974000348	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
891974000349	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
891974000350	RPB12 interaction site [polypeptide binding]; other site
891974000351	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
891974000352	RPB1 interaction site [polypeptide binding]; other site
891974000353	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
891974000354	RPB10 interaction site [polypeptide binding]; other site
891974000355	RPB11 interaction site [polypeptide binding]; other site
891974000356	RPB3 interaction site [polypeptide binding]; other site
891974000357	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
891974000358	core dimer interface [polypeptide binding]; other site
891974000359	peripheral dimer interface [polypeptide binding]; other site
891974000360	L10 interface [polypeptide binding]; other site
891974000361	L11 interface [polypeptide binding]; other site
891974000362	putative EF-Tu interaction site [polypeptide binding]; other site
891974000363	putative EF-G interaction site [polypeptide binding]; other site
891974000364	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
891974000365	23S rRNA interface [nucleotide binding]; other site
891974000366	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
891974000367	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
891974000368	mRNA/rRNA interface [nucleotide binding]; other site
891974000369	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
891974000370	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
891974000371	23S rRNA interface [nucleotide binding]; other site
891974000372	L7/L12 interface [polypeptide binding]; other site
891974000373	putative thiostrepton binding site; other site
891974000374	L25 interface [polypeptide binding]; other site
891974000375	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
891974000376	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
891974000377	putative homodimer interface [polypeptide binding]; other site
891974000378	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
891974000379	heterodimer interface [polypeptide binding]; other site
891974000380	homodimer interface [polypeptide binding]; other site
891974000381	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
891974000382	elongation factor Tu; Reviewed; Region: PRK00049
891974000383	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
891974000384	G1 box; other site
891974000385	GEF interaction site [polypeptide binding]; other site
891974000386	GTP/Mg2+ binding site [chemical binding]; other site
891974000387	Switch I region; other site
891974000388	G2 box; other site
891974000389	G3 box; other site
891974000390	Switch II region; other site
891974000391	G4 box; other site
891974000392	G5 box; other site
891974000393	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
891974000394	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
891974000395	Antibiotic Binding Site [chemical binding]; other site
891974000396	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
891974000397	ATP-binding site [chemical binding]; other site
891974000398	CoA-binding site [chemical binding]; other site
891974000399	Mg2+-binding site [ion binding]; other site
891974000400	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
891974000401	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974000402	dimerization interface [polypeptide binding]; other site
891974000403	putative DNA binding site [nucleotide binding]; other site
891974000404	putative Zn2+ binding site [ion binding]; other site
891974000405	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
891974000406	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
891974000407	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
891974000408	FAD binding domain; Region: FAD_binding_4; pfam01565
891974000409	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
891974000410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974000411	Transposase; Region: HTH_Tnp_1; cl17663
891974000412	Integrase core domain; Region: rve; pfam00665
891974000413	Integrase core domain; Region: rve_3; pfam13683
891974000414	glutamate racemase; Provisional; Region: PRK00865
891974000415	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
891974000416	Walker A motif; other site
891974000417	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
891974000418	GTP binding site; other site
891974000419	Protein of unknown function (DUF1040); Region: DUF1040; cl01176
891974000420	serine/threonine protein kinase; Provisional; Region: PRK11768
891974000421	Phosphotransferase enzyme family; Region: APH; pfam01636
891974000422	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
891974000423	catalytic residues [active]
891974000424	hinge region; other site
891974000425	alpha helical domain; other site
891974000426	DNA polymerase I; Provisional; Region: PRK05755
891974000427	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
891974000428	active site
891974000429	metal binding site 1 [ion binding]; metal-binding site
891974000430	putative 5' ssDNA interaction site; other site
891974000431	metal binding site 3; metal-binding site
891974000432	metal binding site 2 [ion binding]; metal-binding site
891974000433	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
891974000434	putative DNA binding site [nucleotide binding]; other site
891974000435	putative metal binding site [ion binding]; other site
891974000436	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
891974000437	active site
891974000438	catalytic site [active]
891974000439	substrate binding site [chemical binding]; other site
891974000440	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
891974000441	active site
891974000442	DNA binding site [nucleotide binding]
891974000443	catalytic site [active]
891974000444	Predicted GTPase [General function prediction only]; Region: COG0218
891974000445	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
891974000446	G1 box; other site
891974000447	GTP/Mg2+ binding site [chemical binding]; other site
891974000448	Switch I region; other site
891974000449	G2 box; other site
891974000450	G3 box; other site
891974000451	Switch II region; other site
891974000452	G4 box; other site
891974000453	G5 box; other site
891974000454	Der GTPase activator; Provisional; Region: PRK05244
891974000455	Radical SAM superfamily; Region: Radical_SAM; pfam04055
891974000456	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974000457	FeS/SAM binding site; other site
891974000458	HemN C-terminal domain; Region: HemN_C; pfam06969
891974000459	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
891974000460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974000461	active site
891974000462	phosphorylation site [posttranslational modification]
891974000463	intermolecular recognition site; other site
891974000464	dimerization interface [polypeptide binding]; other site
891974000465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974000466	Walker A motif; other site
891974000467	ATP binding site [chemical binding]; other site
891974000468	Walker B motif; other site
891974000469	arginine finger; other site
891974000470	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
891974000471	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
891974000472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974000473	putative active site [active]
891974000474	heme pocket [chemical binding]; other site
891974000475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974000476	dimer interface [polypeptide binding]; other site
891974000477	phosphorylation site [posttranslational modification]
891974000478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974000479	ATP binding site [chemical binding]; other site
891974000480	Mg2+ binding site [ion binding]; other site
891974000481	G-X-G motif; other site
891974000482	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974000483	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
891974000484	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
891974000485	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
891974000486	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
891974000487	G1 box; other site
891974000488	putative GEF interaction site [polypeptide binding]; other site
891974000489	GTP/Mg2+ binding site [chemical binding]; other site
891974000490	Switch I region; other site
891974000491	G2 box; other site
891974000492	G3 box; other site
891974000493	Switch II region; other site
891974000494	G4 box; other site
891974000495	G5 box; other site
891974000496	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
891974000497	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
891974000498	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
891974000499	hypothetical protein; Reviewed; Region: PRK01637
891974000500	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
891974000501	putative active site [active]
891974000502	dimerization interface [polypeptide binding]; other site
891974000503	putative tRNAtyr binding site [nucleotide binding]; other site
891974000504	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
891974000505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974000506	Coenzyme A binding pocket [chemical binding]; other site
891974000507	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
891974000508	AsmA family; Region: AsmA; pfam05170
891974000509	AsmA family; Region: AsmA; pfam05170
891974000510	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974000511	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974000512	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
891974000513	active site
891974000514	substrate binding site [chemical binding]; other site
891974000515	metal binding site [ion binding]; metal-binding site
891974000516	ABC-2 type transporter; Region: ABC2_membrane; cl17235
891974000517	ABC-2 type transporter; Region: ABC2_membrane; cl17235
891974000518	Predicted transcriptional regulator [Transcription]; Region: COG2378
891974000519	HTH domain; Region: HTH_11; pfam08279
891974000520	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
891974000521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974000522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974000523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974000524	hypothetical protein; Provisional; Region: PRK06126
891974000525	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974000526	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974000527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974000528	dimerization interface [polypeptide binding]; other site
891974000529	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
891974000530	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
891974000531	substrate binding site [chemical binding]; other site
891974000532	THF binding site; other site
891974000533	zinc-binding site [ion binding]; other site
891974000534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
891974000535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974000536	dimer interface [polypeptide binding]; other site
891974000537	conserved gate region; other site
891974000538	ABC-ATPase subunit interface; other site
891974000539	maltose transporter membrane protein; Provisional; Region: malF; PRK10999
891974000540	Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785
891974000541	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
891974000542	maltose regulon periplasmic protein; Provisional; Region: PRK10564
891974000543	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974000544	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
891974000545	maltodextrin phosphorylase; Provisional; Region: PRK14985
891974000546	AAA ATPase domain; Region: AAA_16; pfam13191
891974000547	transcriptional regulator MalT; Provisional; Region: PRK04841
891974000548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974000549	DNA binding residues [nucleotide binding]
891974000550	dimerization interface [polypeptide binding]; other site
891974000551	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
891974000552	GAF domain; Region: GAF; pfam01590
891974000553	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
891974000554	nucleotidyl binding site; other site
891974000555	metal binding site [ion binding]; metal-binding site
891974000556	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974000557	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974000558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974000559	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974000560	dimerization interface [polypeptide binding]; other site
891974000561	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
891974000562	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
891974000563	PYR/PP interface [polypeptide binding]; other site
891974000564	dimer interface [polypeptide binding]; other site
891974000565	TPP binding site [chemical binding]; other site
891974000566	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974000567	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974000568	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
891974000569	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
891974000570	TPP-binding site [chemical binding]; other site
891974000571	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974000572	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974000573	putative CheW interface [polypeptide binding]; other site
891974000574	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
891974000575	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974000576	Helix-turn-helix domain; Region: HTH_18; pfam12833
891974000577	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974000578	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974000579	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
891974000580	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974000581	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974000582	Walker A/P-loop; other site
891974000583	ATP binding site [chemical binding]; other site
891974000584	Q-loop/lid; other site
891974000585	ABC transporter signature motif; other site
891974000586	Walker B; other site
891974000587	D-loop; other site
891974000588	H-loop/switch region; other site
891974000589	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974000590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974000591	dimer interface [polypeptide binding]; other site
891974000592	conserved gate region; other site
891974000593	putative PBP binding loops; other site
891974000594	ABC-ATPase subunit interface; other site
891974000595	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974000596	membrane-bound complex binding site; other site
891974000597	hinge residues; other site
891974000598	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974000599	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
891974000600	dimerization interface [polypeptide binding]; other site
891974000601	ligand binding site [chemical binding]; other site
891974000602	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974000603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974000604	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974000605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974000606	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974000607	dimerization interface [polypeptide binding]; other site
891974000608	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
891974000609	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
891974000610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974000611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974000612	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
891974000613	DNA binding residues [nucleotide binding]
891974000614	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
891974000615	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
891974000616	putative active site pocket [active]
891974000617	dimerization interface [polypeptide binding]; other site
891974000618	putative catalytic residue [active]
891974000619	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
891974000620	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
891974000621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974000622	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974000623	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974000624	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974000625	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
891974000626	substrate binding site [chemical binding]; other site
891974000627	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
891974000628	substrate binding site [chemical binding]; other site
891974000629	ligand binding site [chemical binding]; other site
891974000630	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
891974000631	2-isopropylmalate synthase; Validated; Region: PRK00915
891974000632	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
891974000633	active site
891974000634	catalytic residues [active]
891974000635	metal binding site [ion binding]; metal-binding site
891974000636	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
891974000637	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
891974000638	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
891974000639	PYR/PP interface [polypeptide binding]; other site
891974000640	dimer interface [polypeptide binding]; other site
891974000641	TPP binding site [chemical binding]; other site
891974000642	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974000643	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
891974000644	TPP-binding site [chemical binding]; other site
891974000645	dimer interface [polypeptide binding]; other site
891974000646	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
891974000647	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
891974000648	putative valine binding site [chemical binding]; other site
891974000649	dimer interface [polypeptide binding]; other site
891974000650	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
891974000651	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
891974000652	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974000653	DNA binding site [nucleotide binding]
891974000654	domain linker motif; other site
891974000655	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
891974000656	dimerization interface [polypeptide binding]; other site
891974000657	ligand binding site [chemical binding]; other site
891974000658	cell division protein MraZ; Reviewed; Region: PRK00326
891974000659	MraZ protein; Region: MraZ; pfam02381
891974000660	MraZ protein; Region: MraZ; pfam02381
891974000661	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
891974000662	cell division protein FtsL; Provisional; Region: PRK10772
891974000663	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
891974000664	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
891974000665	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
891974000666	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
891974000667	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
891974000668	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974000669	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974000670	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
891974000671	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
891974000672	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974000673	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974000674	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
891974000675	Mg++ binding site [ion binding]; other site
891974000676	putative catalytic motif [active]
891974000677	putative substrate binding site [chemical binding]; other site
891974000678	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
891974000679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974000680	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974000681	cell division protein FtsW; Provisional; Region: PRK10774
891974000682	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
891974000683	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
891974000684	active site
891974000685	homodimer interface [polypeptide binding]; other site
891974000686	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
891974000687	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
891974000688	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974000689	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974000690	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
891974000691	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
891974000692	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
891974000693	cell division protein FtsQ; Provisional; Region: PRK10775
891974000694	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
891974000695	Cell division protein FtsQ; Region: FtsQ; pfam03799
891974000696	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
891974000697	Cell division protein FtsA; Region: FtsA; pfam14450
891974000698	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974000699	Cell division protein FtsA; Region: FtsA; pfam14450
891974000700	cell division protein FtsZ; Validated; Region: PRK09330
891974000701	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
891974000702	nucleotide binding site [chemical binding]; other site
891974000703	SulA interaction site; other site
891974000704	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
891974000705	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
891974000706	SecA regulator SecM; Provisional; Region: PRK02943
891974000707	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
891974000708	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
891974000709	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974000710	nucleotide binding region [chemical binding]; other site
891974000711	ATP-binding site [chemical binding]; other site
891974000712	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
891974000713	SEC-C motif; Region: SEC-C; pfam02810
891974000714	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
891974000715	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
891974000716	active site
891974000717	8-oxo-dGMP binding site [chemical binding]; other site
891974000718	nudix motif; other site
891974000719	metal binding site [ion binding]; metal-binding site
891974000720	DNA gyrase inhibitor; Reviewed; Region: PRK00418
891974000721	hypothetical protein; Provisional; Region: PRK05287
891974000722	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
891974000723	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
891974000724	CoA-binding site [chemical binding]; other site
891974000725	ATP-binding [chemical binding]; other site
891974000726	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
891974000727	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
891974000728	active site
891974000729	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974000730	type IV pilin biogenesis protein; Provisional; Region: PRK10573
891974000731	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
891974000732	type IV pilin biogenesis protein; Provisional; Region: PRK10573
891974000733	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
891974000734	Walker A motif; other site
891974000735	ATP binding site [chemical binding]; other site
891974000736	Walker B motif; other site
891974000737	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
891974000738	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
891974000739	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
891974000740	putative major pilin subunit; Provisional; Region: PRK10574
891974000741	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
891974000742	Pilin (bacterial filament); Region: Pilin; pfam00114
891974000743	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
891974000744	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
891974000745	dimerization interface [polypeptide binding]; other site
891974000746	active site
891974000747	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
891974000748	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
891974000749	amidase catalytic site [active]
891974000750	Zn binding residues [ion binding]; other site
891974000751	substrate binding site [chemical binding]; other site
891974000752	regulatory protein AmpE; Provisional; Region: PRK10987
891974000753	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
891974000754	active site
891974000755	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
891974000756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000757	putative substrate translocation pore; other site
891974000758	aromatic amino acid transporter; Provisional; Region: PRK10238
891974000759	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
891974000760	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
891974000761	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974000762	DNA-binding site [nucleotide binding]; DNA binding site
891974000763	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
891974000764	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
891974000765	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
891974000766	dimer interface [polypeptide binding]; other site
891974000767	TPP-binding site [chemical binding]; other site
891974000768	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
891974000769	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
891974000770	E3 interaction surface; other site
891974000771	lipoyl attachment site [posttranslational modification]; other site
891974000772	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
891974000773	E3 interaction surface; other site
891974000774	lipoyl attachment site [posttranslational modification]; other site
891974000775	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
891974000776	E3 interaction surface; other site
891974000777	lipoyl attachment site [posttranslational modification]; other site
891974000778	e3 binding domain; Region: E3_binding; pfam02817
891974000779	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
891974000780	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
891974000781	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974000782	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974000783	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
891974000784	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
891974000785	Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
891974000786	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
891974000787	substrate binding site [chemical binding]; other site
891974000788	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
891974000789	substrate binding site [chemical binding]; other site
891974000790	ligand binding site [chemical binding]; other site
891974000791	hypothetical protein; Provisional; Region: PRK05248
891974000792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974000793	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974000794	putative substrate translocation pore; other site
891974000795	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
891974000796	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
891974000797	putative ligand binding site [chemical binding]; other site
891974000798	putative NAD binding site [chemical binding]; other site
891974000799	catalytic site [active]
891974000800	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974000801	Class I aldolases; Region: Aldolase_Class_I; cl17187
891974000802	DNA helicase TIP49, TBP-interacting protein [Transcription]; Region: TIP49; COG1224
891974000803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
891974000804	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
891974000805	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
891974000806	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
891974000807	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974000808	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974000809	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
891974000810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974000811	S-adenosylmethionine binding site [chemical binding]; other site
891974000812	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
891974000813	multicopper oxidase; Provisional; Region: PRK10965
891974000814	Cupredoxin superfamily; Region: Cupredoxin; cl19115
891974000815	Cupredoxin superfamily; Region: Cupredoxin; cl19115
891974000816	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
891974000817	Domain 2 interface [polypeptide binding]; other site
891974000818	Domain 1 interface [polypeptide binding]; other site
891974000819	Type 1 (T1) Cu binding site [ion binding]; other site
891974000820	trinuclear Cu binding site [ion binding]; other site
891974000821	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974000822	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974000823	catalytic residue [active]
891974000824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974000825	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974000826	active site
891974000827	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
891974000828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000829	Walker A/P-loop; other site
891974000830	ATP binding site [chemical binding]; other site
891974000831	Q-loop/lid; other site
891974000832	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
891974000833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000834	Walker B; other site
891974000835	D-loop; other site
891974000836	H-loop/switch region; other site
891974000837	inner membrane transport permease; Provisional; Region: PRK15066
891974000838	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
891974000839	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
891974000840	tetramerization interface [polypeptide binding]; other site
891974000841	active site
891974000842	Pantoate-beta-alanine ligase; Region: PanC; cd00560
891974000843	active site
891974000844	ATP-binding site [chemical binding]; other site
891974000845	pantoate-binding site; other site
891974000846	HXXH motif; other site
891974000847	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
891974000848	oligomerization interface [polypeptide binding]; other site
891974000849	active site
891974000850	metal binding site [ion binding]; metal-binding site
891974000851	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
891974000852	catalytic center binding site [active]
891974000853	ATP binding site [chemical binding]; other site
891974000854	Poly A polymerase head domain; Region: PolyA_pol; pfam01743
891974000855	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
891974000856	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
891974000857	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
891974000858	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
891974000859	KMSKS motif; other site
891974000860	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
891974000861	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
891974000862	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
891974000863	2'-5' RNA ligase; Provisional; Region: PRK15124
891974000864	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
891974000865	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
891974000866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974000867	ATP binding site [chemical binding]; other site
891974000868	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974000869	nucleotide binding region [chemical binding]; other site
891974000870	ATP-binding site [chemical binding]; other site
891974000871	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
891974000872	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
891974000873	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
891974000874	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
891974000875	Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812
891974000876	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
891974000877	Transglycosylase; Region: Transgly; pfam00912
891974000878	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974000879	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974000880	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974000881	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974000882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000883	Walker A/P-loop; other site
891974000884	ATP binding site [chemical binding]; other site
891974000885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000886	Q-loop/lid; other site
891974000887	ABC transporter signature motif; other site
891974000888	Walker B; other site
891974000889	D-loop; other site
891974000890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974000891	H-loop/switch region; other site
891974000892	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974000893	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
891974000894	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974000895	intersubunit interface [polypeptide binding]; other site
891974000896	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
891974000897	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974000898	dimer interface [polypeptide binding]; other site
891974000899	putative PBP binding regions; other site
891974000900	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974000901	dimer interface [polypeptide binding]; other site
891974000902	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
891974000903	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974000904	inhibitor-cofactor binding pocket; inhibition site
891974000905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974000906	catalytic residue [active]
891974000907	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
891974000908	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974000909	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974000910	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
891974000911	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
891974000912	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
891974000913	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
891974000914	Zn2+ binding site [ion binding]; other site
891974000915	Mg2+ binding site [ion binding]; other site
891974000916	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
891974000917	serine endoprotease; Provisional; Region: PRK10942
891974000918	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
891974000919	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
891974000920	protein binding site [polypeptide binding]; other site
891974000921	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
891974000922	protein binding site [polypeptide binding]; other site
891974000923	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
891974000924	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
891974000925	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
891974000926	hypothetical protein; Provisional; Region: PRK13677
891974000927	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
891974000928	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
891974000929	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
891974000930	trimer interface [polypeptide binding]; other site
891974000931	active site
891974000932	substrate binding site [chemical binding]; other site
891974000933	CoA binding site [chemical binding]; other site
891974000934	PII uridylyl-transferase; Provisional; Region: PRK05007
891974000935	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
891974000936	metal binding triad; other site
891974000937	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
891974000938	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
891974000939	Zn2+ binding site [ion binding]; other site
891974000940	Mg2+ binding site [ion binding]; other site
891974000941	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
891974000942	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
891974000943	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
891974000944	active site
891974000945	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
891974000946	active site
891974000947	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
891974000948	rRNA interaction site [nucleotide binding]; other site
891974000949	S8 interaction site; other site
891974000950	putative laminin-1 binding site; other site
891974000951	elongation factor Ts; Provisional; Region: tsf; PRK09377
891974000952	UBA/TS-N domain; Region: UBA; pfam00627
891974000953	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
891974000954	putative nucleotide binding site [chemical binding]; other site
891974000955	uridine monophosphate binding site [chemical binding]; other site
891974000956	homohexameric interface [polypeptide binding]; other site
891974000957	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
891974000958	hinge region; other site
891974000959	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
891974000960	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
891974000961	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
891974000962	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
891974000963	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
891974000964	active site
891974000965	dimer interface [polypeptide binding]; other site
891974000966	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
891974000967	zinc metallopeptidase RseP; Provisional; Region: PRK10779
891974000968	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
891974000969	active site
891974000970	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
891974000971	protein binding site [polypeptide binding]; other site
891974000972	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
891974000973	protein binding site [polypeptide binding]; other site
891974000974	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
891974000975	putative substrate binding region [chemical binding]; other site
891974000976	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
891974000977	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974000978	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974000979	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974000980	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974000981	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974000982	Surface antigen; Region: Bac_surface_Ag; pfam01103
891974000983	periplasmic chaperone; Provisional; Region: PRK10780
891974000984	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
891974000985	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
891974000986	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
891974000987	trimer interface [polypeptide binding]; other site
891974000988	active site
891974000989	UDP-GlcNAc binding site [chemical binding]; other site
891974000990	lipid binding site [chemical binding]; lipid-binding site
891974000991	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
891974000992	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
891974000993	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
891974000994	active site
891974000995	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
891974000996	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
891974000997	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
891974000998	RNA/DNA hybrid binding site [nucleotide binding]; other site
891974000999	active site
891974001000	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
891974001001	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
891974001002	putative active site [active]
891974001003	putative PHP Thumb interface [polypeptide binding]; other site
891974001004	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
891974001005	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
891974001006	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
891974001007	generic binding surface II; other site
891974001008	generic binding surface I; other site
891974001009	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
891974001010	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974001011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974001012	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974001013	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974001014	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974001015	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974001016	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974001017	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
891974001018	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
891974001019	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
891974001020	Moco binding site; other site
891974001021	metal coordination site [ion binding]; other site
891974001022	Chorismate mutase type II; Region: CM_2; cl00693
891974001023	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
891974001024	putative oxidoreductase; Provisional; Region: PRK10083
891974001025	putative NAD(P) binding site [chemical binding]; other site
891974001026	catalytic Zn binding site [ion binding]; other site
891974001027	structural Zn binding site [ion binding]; other site
891974001028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001029	D-galactonate transporter; Region: 2A0114; TIGR00893
891974001030	putative substrate translocation pore; other site
891974001031	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
891974001032	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
891974001033	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974001034	Transcriptional regulators [Transcription]; Region: GntR; COG1802
891974001035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974001036	DNA-binding site [nucleotide binding]; DNA binding site
891974001037	FCD domain; Region: FCD; pfam07729
891974001038	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
891974001039	putative active site; other site
891974001040	catalytic residue [active]
891974001041	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
891974001042	dimer interface [polypeptide binding]; other site
891974001043	substrate binding site [chemical binding]; other site
891974001044	ATP binding site [chemical binding]; other site
891974001045	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
891974001046	substrate binding site [chemical binding]; other site
891974001047	multimerization interface [polypeptide binding]; other site
891974001048	ATP binding site [chemical binding]; other site
891974001049	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974001050	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
891974001051	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974001053	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974001054	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974001055	putative transporter; Provisional; Region: PRK10504
891974001056	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
891974001057	HAMP domain; Region: HAMP; pfam00672
891974001058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974001059	dimer interface [polypeptide binding]; other site
891974001060	phosphorylation site [posttranslational modification]
891974001061	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
891974001062	putative protease; Provisional; Region: PRK15452
891974001063	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
891974001064	lipid kinase; Reviewed; Region: PRK13054
891974001065	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
891974001066	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974001067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974001068	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974001069	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974001070	lysine decarboxylase LdcC; Provisional; Region: PRK15399
891974001071	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
891974001072	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
891974001073	homodimer interface [polypeptide binding]; other site
891974001074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974001075	catalytic residue [active]
891974001076	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
891974001077	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
891974001078	active site
891974001079	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
891974001080	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
891974001081	Ligand Binding Site [chemical binding]; other site
891974001082	TilS substrate binding domain; Region: TilS; pfam09179
891974001083	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
891974001084	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974001085	Cytochrome c553 [Energy production and conversion]; Region: COG2863
891974001086	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
891974001087	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
891974001088	hypothetical protein; Provisional; Region: PRK09256
891974001089	prolyl-tRNA synthetase; Provisional; Region: PRK09194
891974001090	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
891974001091	dimer interface [polypeptide binding]; other site
891974001092	motif 1; other site
891974001093	active site
891974001094	motif 2; other site
891974001095	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
891974001096	putative deacylase active site [active]
891974001097	motif 3; other site
891974001098	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
891974001099	anticodon binding site; other site
891974001100	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
891974001101	homodimer interaction site [polypeptide binding]; other site
891974001102	cofactor binding site; other site
891974001103	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
891974001104	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
891974001105	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
891974001106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001107	dimer interface [polypeptide binding]; other site
891974001108	conserved gate region; other site
891974001109	putative PBP binding loops; other site
891974001110	ABC-ATPase subunit interface; other site
891974001111	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
891974001112	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
891974001113	Walker A/P-loop; other site
891974001114	ATP binding site [chemical binding]; other site
891974001115	Q-loop/lid; other site
891974001116	ABC transporter signature motif; other site
891974001117	Walker B; other site
891974001118	D-loop; other site
891974001119	H-loop/switch region; other site
891974001120	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
891974001121	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
891974001122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974001123	active site
891974001124	motif I; other site
891974001125	motif II; other site
891974001126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974001127	Transposase; Region: HTH_Tnp_1; cl17663
891974001128	Integrase core domain; Region: rve; pfam00665
891974001129	Integrase core domain; Region: rve_3; pfam13683
891974001130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974001131	active site
891974001132	catalytic tetrad [active]
891974001133	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001135	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001136	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974001137	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001138	dimerization interface [polypeptide binding]; other site
891974001139	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974001140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001141	putative substrate translocation pore; other site
891974001142	hypothetical protein; Provisional; Region: PRK05421
891974001143	putative catalytic site [active]
891974001144	putative metal binding site [ion binding]; other site
891974001145	putative phosphate binding site [ion binding]; other site
891974001146	putative catalytic site [active]
891974001147	putative phosphate binding site [ion binding]; other site
891974001148	putative metal binding site [ion binding]; other site
891974001149	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974001150	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974001151	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974001152	catalytic residue [active]
891974001153	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974001154	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
891974001155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974001156	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
891974001157	RNA/DNA hybrid binding site [nucleotide binding]; other site
891974001158	active site
891974001159	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
891974001160	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
891974001161	active site
891974001162	catalytic site [active]
891974001163	substrate binding site [chemical binding]; other site
891974001164	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
891974001165	Na binding site [ion binding]; other site
891974001166	putative substrate binding site [chemical binding]; other site
891974001167	Transcriptional regulators [Transcription]; Region: GntR; COG1802
891974001168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974001169	DNA-binding site [nucleotide binding]; DNA binding site
891974001170	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
891974001171	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
891974001172	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
891974001173	active site
891974001174	catalytic site [active]
891974001175	tetramer interface [polypeptide binding]; other site
891974001176	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
891974001177	amidase; Provisional; Region: PRK09201
891974001178	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
891974001179	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
891974001180	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974001181	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974001182	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974001183	putative active site [active]
891974001184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974001185	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974001186	substrate binding pocket [chemical binding]; other site
891974001187	membrane-bound complex binding site; other site
891974001188	hinge residues; other site
891974001189	ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Region: ectoine_ehuC; TIGR03004
891974001190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001191	dimer interface [polypeptide binding]; other site
891974001192	conserved gate region; other site
891974001193	putative PBP binding loops; other site
891974001194	ABC-ATPase subunit interface; other site
891974001195	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974001196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001197	dimer interface [polypeptide binding]; other site
891974001198	conserved gate region; other site
891974001199	putative PBP binding loops; other site
891974001200	ABC-ATPase subunit interface; other site
891974001201	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974001202	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974001203	Walker A/P-loop; other site
891974001204	ATP binding site [chemical binding]; other site
891974001205	Q-loop/lid; other site
891974001206	ABC transporter signature motif; other site
891974001207	Walker B; other site
891974001208	D-loop; other site
891974001209	H-loop/switch region; other site
891974001210	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
891974001211	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974001212	catalytic residue [active]
891974001213	allantoate amidohydrolase; Reviewed; Region: PRK09290
891974001214	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
891974001215	active site
891974001216	metal binding site [ion binding]; metal-binding site
891974001217	dimer interface [polypeptide binding]; other site
891974001218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001219	ABC-ATPase subunit interface; other site
891974001220	putative PBP binding loops; other site
891974001221	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974001222	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974001223	Walker A/P-loop; other site
891974001224	ATP binding site [chemical binding]; other site
891974001225	Q-loop/lid; other site
891974001226	ABC transporter signature motif; other site
891974001227	Walker B; other site
891974001228	D-loop; other site
891974001229	H-loop/switch region; other site
891974001230	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
891974001231	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
891974001232	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
891974001233	dimer interface [polypeptide binding]; other site
891974001234	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
891974001235	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
891974001236	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
891974001237	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
891974001238	substrate binding pocket [chemical binding]; other site
891974001239	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
891974001240	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
891974001241	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
891974001242	active site
891974001243	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
891974001244	active site
891974001245	inhibitor site; inhibition site
891974001246	dimer interface [polypeptide binding]; other site
891974001247	catalytic residue [active]
891974001248	hypothetical protein; Validated; Region: PRK06186
891974001249	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974001250	conserved cys residue [active]
891974001251	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974001252	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974001253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974001254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974001255	homodimer interface [polypeptide binding]; other site
891974001256	catalytic residue [active]
891974001257	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
891974001258	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
891974001259	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
891974001260	haemagglutination activity domain; Region: Haemagg_act; cl05436
891974001261	haemagglutination activity domain; Region: Haemagg_act; cl05436
891974001262	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
891974001263	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
891974001264	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
891974001265	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
891974001266	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
891974001267	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
891974001268	dimer interface [polypeptide binding]; other site
891974001269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974001270	dimerization interface [polypeptide binding]; other site
891974001271	putative DNA binding site [nucleotide binding]; other site
891974001272	putative Zn2+ binding site [ion binding]; other site
891974001273	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974001274	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
891974001275	non-prolyl cis peptide bond; other site
891974001276	dimer interface [polypeptide binding]; other site
891974001277	active site
891974001278	insertion regions; other site
891974001279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001280	putative substrate translocation pore; other site
891974001281	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
891974001282	beta-carotene hydroxylase; Region: PLN02601
891974001283	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
891974001284	active site lid residues [active]
891974001285	substrate binding pocket [chemical binding]; other site
891974001286	catalytic residues [active]
891974001287	substrate-Mg2+ binding site; other site
891974001288	aspartate-rich region 1; other site
891974001289	aspartate-rich region 2; other site
891974001290	phytoene desaturase; Region: crtI_fam; TIGR02734
891974001291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001292	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
891974001293	lycopene cyclase; Region: lycopene_cycl; TIGR01789
891974001294	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
891974001295	glycosyltransferase, MGT family; Region: MGT; TIGR01426
891974001296	active site
891974001297	TDP-binding site; other site
891974001298	acceptor substrate-binding pocket; other site
891974001299	homodimer interface [polypeptide binding]; other site
891974001300	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
891974001301	substrate binding pocket [chemical binding]; other site
891974001302	chain length determination region; other site
891974001303	substrate-Mg2+ binding site; other site
891974001304	catalytic residues [active]
891974001305	aspartate-rich region 1; other site
891974001306	active site lid residues [active]
891974001307	aspartate-rich region 2; other site
891974001308	FAD dependent oxidoreductase; Region: DAO; pfam01266
891974001309	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974001310	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001311	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
891974001312	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
891974001313	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974001314	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
891974001315	NAD(P) binding site [chemical binding]; other site
891974001316	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974001317	toxin MazF; Provisional; Region: PRK09907
891974001318	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
891974001319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974001320	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974001321	non-specific DNA binding site [nucleotide binding]; other site
891974001322	salt bridge; other site
891974001323	sequence-specific DNA binding site [nucleotide binding]; other site
891974001324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001325	putative substrate translocation pore; other site
891974001326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001327	TOBE domain; Region: TOBE_2; pfam08402
891974001328	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
891974001329	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
891974001330	Walker A/P-loop; other site
891974001331	ATP binding site [chemical binding]; other site
891974001332	Q-loop/lid; other site
891974001333	ABC transporter signature motif; other site
891974001334	Walker B; other site
891974001335	D-loop; other site
891974001336	H-loop/switch region; other site
891974001337	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974001338	ATP binding site [chemical binding]; other site
891974001339	substrate binding site [chemical binding]; other site
891974001340	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974001341	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
891974001342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001343	dimer interface [polypeptide binding]; other site
891974001344	conserved gate region; other site
891974001345	putative PBP binding loops; other site
891974001346	ABC-ATPase subunit interface; other site
891974001347	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
891974001348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001349	dimer interface [polypeptide binding]; other site
891974001350	conserved gate region; other site
891974001351	putative PBP binding loops; other site
891974001352	ABC-ATPase subunit interface; other site
891974001353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
891974001354	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974001355	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974001356	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
891974001357	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974001358	putative DNA binding site [nucleotide binding]; other site
891974001359	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974001360	putative Zn2+ binding site [ion binding]; other site
891974001361	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974001362	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974001363	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974001364	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
891974001365	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
891974001366	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974001367	Walker A/P-loop; other site
891974001368	ATP binding site [chemical binding]; other site
891974001369	Q-loop/lid; other site
891974001370	ABC transporter signature motif; other site
891974001371	Walker B; other site
891974001372	D-loop; other site
891974001373	H-loop/switch region; other site
891974001374	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974001375	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974001376	Walker A/P-loop; other site
891974001377	ATP binding site [chemical binding]; other site
891974001378	Q-loop/lid; other site
891974001379	ABC transporter signature motif; other site
891974001380	Walker B; other site
891974001381	D-loop; other site
891974001382	H-loop/switch region; other site
891974001383	Uncharacterized conserved protein [Function unknown]; Region: COG5476
891974001384	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
891974001385	MlrC C-terminus; Region: MlrC_C; pfam07171
891974001386	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974001387	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974001388	putative DNA binding site [nucleotide binding]; other site
891974001389	putative Zn2+ binding site [ion binding]; other site
891974001390	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974001391	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974001392	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974001393	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974001394	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974001395	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
891974001396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974001397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001398	ABC-ATPase subunit interface; other site
891974001399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974001400	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
891974001401	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974001402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001403	dimer interface [polypeptide binding]; other site
891974001404	conserved gate region; other site
891974001405	putative PBP binding loops; other site
891974001406	ABC-ATPase subunit interface; other site
891974001407	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974001408	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974001409	nucleotide binding site [chemical binding]; other site
891974001410	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974001411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001412	putative substrate translocation pore; other site
891974001413	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
891974001414	putative heme binding pocket [chemical binding]; other site
891974001415	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
891974001416	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
891974001417	DNA binding residues [nucleotide binding]
891974001418	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
891974001419	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
891974001420	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
891974001421	putative effector binding pocket; other site
891974001422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974001424	Pirin-related protein [General function prediction only]; Region: COG1741
891974001425	Pirin; Region: Pirin; pfam02678
891974001426	lipoprotein; Provisional; Region: PRK10540
891974001427	lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317
891974001428	active site
891974001429	homopentamer interface [polypeptide binding]; other site
891974001430	FAD dependent oxidoreductase; Region: DAO; pfam01266
891974001431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
891974001432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001433	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
891974001434	thiS-thiF/thiG interaction site; other site
891974001435	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
891974001436	ThiS interaction site; other site
891974001437	putative active site [active]
891974001438	tetramer interface [polypeptide binding]; other site
891974001439	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
891974001440	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
891974001441	ATP binding site [chemical binding]; other site
891974001442	substrate interface [chemical binding]; other site
891974001443	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
891974001444	active site residue [active]
891974001445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001446	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
891974001447	Walker A/P-loop; other site
891974001448	ATP binding site [chemical binding]; other site
891974001449	Q-loop/lid; other site
891974001450	ABC transporter signature motif; other site
891974001451	Walker B; other site
891974001452	D-loop; other site
891974001453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001454	H-loop/switch region; other site
891974001455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974001456	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
891974001457	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
891974001458	NMT1/THI5 like; Region: NMT1; pfam09084
891974001459	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
891974001460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001461	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974001465	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001466	dimerization interface [polypeptide binding]; other site
891974001467	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974001468	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
891974001469	putative NAD(P) binding site [chemical binding]; other site
891974001470	dimer interface [polypeptide binding]; other site
891974001471	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
891974001472	FMN binding site [chemical binding]; other site
891974001473	dimer interface [polypeptide binding]; other site
891974001474	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
891974001475	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
891974001476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974001477	short chain dehydrogenase; Region: adh_short; pfam00106
891974001478	NAD(P) binding site [chemical binding]; other site
891974001479	active site
891974001480	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001481	dimerization interface [polypeptide binding]; other site
891974001482	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001484	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974001485	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974001486	DNA binding site [nucleotide binding]
891974001487	domain linker motif; other site
891974001488	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
891974001489	putative dimerization interface [polypeptide binding]; other site
891974001490	putative ligand binding site [chemical binding]; other site
891974001491	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
891974001492	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
891974001493	active site
891974001494	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
891974001495	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974001496	ligand binding site [chemical binding]; other site
891974001497	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
891974001498	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974001499	metal binding site [ion binding]; metal-binding site
891974001500	active site
891974001501	I-site; other site
891974001502	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
891974001503	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
891974001504	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
891974001505	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164
891974001506	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974001507	active site turn [active]
891974001508	phosphorylation site [posttranslational modification]
891974001509	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164
891974001510	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974001511	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974001512	DNA binding site [nucleotide binding]
891974001513	domain linker motif; other site
891974001514	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974001515	Transcriptional regulators [Transcription]; Region: GntR; COG1802
891974001516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
891974001517	DNA-binding site [nucleotide binding]; DNA binding site
891974001518	FCD domain; Region: FCD; pfam07729
891974001519	Amidase; Region: Amidase; cl11426
891974001520	Amidase; Region: Amidase; cl11426
891974001521	metabolite-proton symporter; Region: 2A0106; TIGR00883
891974001522	metabolite-proton symporter; Region: 2A0106; TIGR00883
891974001523	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974001524	metal binding site [ion binding]; metal-binding site
891974001525	active site
891974001526	I-site; other site
891974001527	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974001528	CHASE4 domain; Region: CHASE4; cl01308
891974001529	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
891974001530	Acyltransferase family; Region: Acyl_transf_3; cl19154
891974001531	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974001532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974001533	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
891974001534	putative active site [active]
891974001535	heme pocket [chemical binding]; other site
891974001536	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974001537	putative active site [active]
891974001538	heme pocket [chemical binding]; other site
891974001539	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974001540	putative CheW interface [polypeptide binding]; other site
891974001541	Nitronate monooxygenase; Region: NMO; pfam03060
891974001542	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
891974001543	FMN binding site [chemical binding]; other site
891974001544	substrate binding site [chemical binding]; other site
891974001545	putative catalytic residue [active]
891974001546	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
891974001547	active site
891974001548	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
891974001549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001550	putative substrate translocation pore; other site
891974001551	D-galactonate transporter; Region: 2A0114; TIGR00893
891974001552	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
891974001553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001554	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
891974001555	Strictosidine synthase; Region: Str_synth; cl19733
891974001556	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974001557	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974001558	NAD binding site [chemical binding]; other site
891974001559	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974001560	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974001561	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
891974001562	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
891974001563	Transcriptional regulator [Transcription]; Region: IclR; COG1414
891974001564	Bacterial transcriptional regulator; Region: IclR; pfam01614
891974001565	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974001566	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
891974001567	homotrimer interaction site [polypeptide binding]; other site
891974001568	putative active site [active]
891974001569	Uncharacterized conserved protein [Function unknown]; Region: COG3342
891974001570	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
891974001571	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
891974001572	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
891974001573	metal binding site [ion binding]; metal-binding site
891974001574	putative dimer interface [polypeptide binding]; other site
891974001575	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
891974001576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001577	Walker A/P-loop; other site
891974001578	ATP binding site [chemical binding]; other site
891974001579	Q-loop/lid; other site
891974001580	ABC transporter signature motif; other site
891974001581	Walker B; other site
891974001582	D-loop; other site
891974001583	H-loop/switch region; other site
891974001584	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
891974001585	trimer interface [polypeptide binding]; other site
891974001586	active site
891974001587	dimer interface [polypeptide binding]; other site
891974001588	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974001589	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974001590	NAD binding site [chemical binding]; other site
891974001591	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974001592	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974001593	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001595	dimerization interface [polypeptide binding]; other site
891974001596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974001597	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
891974001598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001599	putative PBP binding loops; other site
891974001600	dimer interface [polypeptide binding]; other site
891974001601	ABC-ATPase subunit interface; other site
891974001602	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
891974001603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001604	dimer interface [polypeptide binding]; other site
891974001605	conserved gate region; other site
891974001606	putative PBP binding loops; other site
891974001607	ABC-ATPase subunit interface; other site
891974001608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001609	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
891974001610	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
891974001611	malate:quinone oxidoreductase; Validated; Region: PRK05257
891974001612	Predicted dehydrogenase [General function prediction only]; Region: COG0579
891974001613	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
891974001614	substrate binding site [chemical binding]; other site
891974001615	ligand binding site [chemical binding]; other site
891974001616	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
891974001617	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
891974001618	substrate binding site [chemical binding]; other site
891974001619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
891974001620	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974001621	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974001623	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001624	dimerization interface [polypeptide binding]; other site
891974001625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001626	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974001627	K+ potassium transporter; Region: K_trans; cl15781
891974001628	K+ potassium transporter; Region: K_trans; cl15781
891974001629	K+ potassium transporter; Region: K_trans; cl15781
891974001630	K+ potassium transporter; Region: K_trans; cl15781
891974001631	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
891974001632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001633	dimer interface [polypeptide binding]; other site
891974001634	conserved gate region; other site
891974001635	putative PBP binding loops; other site
891974001636	ABC-ATPase subunit interface; other site
891974001637	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
891974001638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974001639	ATP binding site [chemical binding]; other site
891974001640	Mg2+ binding site [ion binding]; other site
891974001641	G-X-G motif; other site
891974001642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974001643	active site
891974001644	phosphorylation site [posttranslational modification]
891974001645	intermolecular recognition site; other site
891974001646	dimerization interface [polypeptide binding]; other site
891974001647	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001648	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
891974001649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001650	Q-loop/lid; other site
891974001651	ABC transporter signature motif; other site
891974001652	Walker B; other site
891974001653	D-loop; other site
891974001654	H-loop/switch region; other site
891974001655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001656	Walker A/P-loop; other site
891974001657	ATP binding site [chemical binding]; other site
891974001658	Q-loop/lid; other site
891974001659	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
891974001660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001661	ABC transporter signature motif; other site
891974001662	Walker B; other site
891974001663	D-loop; other site
891974001664	H-loop/switch region; other site
891974001665	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974001666	TM-ABC transporter signature motif; other site
891974001667	Phage Terminase; Region: Terminase_1; cl19862
891974001668	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974001669	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974001670	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974001671	Transcriptional regulator; Region: Rrf2; cl17282
891974001672	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974001673	Integrase core domain; Region: rve; pfam00665
891974001674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974001675	non-specific DNA binding site [nucleotide binding]; other site
891974001676	salt bridge; other site
891974001677	sequence-specific DNA binding site [nucleotide binding]; other site
891974001678	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974001679	AAA domain; Region: AAA_22; pfam13401
891974001680	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974001681	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974001682	Mor transcription activator family; Region: Mor; pfam08765
891974001683	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974001684	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
891974001685	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974001686	TM-ABC transporter signature motif; other site
891974001687	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974001688	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
891974001689	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
891974001690	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
891974001691	TM-ABC transporter signature motif; other site
891974001692	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
891974001693	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
891974001694	Walker A/P-loop; other site
891974001695	ATP binding site [chemical binding]; other site
891974001696	Q-loop/lid; other site
891974001697	ABC transporter signature motif; other site
891974001698	Walker B; other site
891974001699	D-loop; other site
891974001700	H-loop/switch region; other site
891974001701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001703	Walker A/P-loop; other site
891974001704	ATP binding site [chemical binding]; other site
891974001705	Q-loop/lid; other site
891974001706	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
891974001707	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
891974001708	ligand-binding site [chemical binding]; other site
891974001709	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
891974001710	Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; cl01267
891974001711	Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; cl01267
891974001712	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
891974001713	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974001714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
891974001715	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
891974001716	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
891974001717	generic binding surface II; other site
891974001718	ssDNA binding site; other site
891974001719	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974001720	ATP binding site [chemical binding]; other site
891974001721	putative Mg++ binding site [ion binding]; other site
891974001722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974001723	nucleotide binding region [chemical binding]; other site
891974001724	ATP-binding site [chemical binding]; other site
891974001725	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
891974001726	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
891974001727	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
891974001728	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
891974001729	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
891974001730	Zn2+ binding site [ion binding]; other site
891974001731	Mg2+ binding site [ion binding]; other site
891974001732	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
891974001733	synthetase active site [active]
891974001734	NTP binding site [chemical binding]; other site
891974001735	metal binding site [ion binding]; metal-binding site
891974001736	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
891974001737	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
891974001738	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
891974001739	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
891974001740	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
891974001741	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
891974001742	nucleotide binding pocket [chemical binding]; other site
891974001743	K-X-D-G motif; other site
891974001744	catalytic site [active]
891974001745	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
891974001746	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
891974001747	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
891974001748	Predicted membrane protein [Function unknown]; Region: COG2860
891974001749	UPF0126 domain; Region: UPF0126; pfam03458
891974001750	UPF0126 domain; Region: UPF0126; pfam03458
891974001751	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
891974001752	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974001753	DNA binding residues [nucleotide binding]
891974001754	dimerization interface [polypeptide binding]; other site
891974001755	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974001756	primosome assembly protein PriA; Validated; Region: PRK05580
891974001757	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974001758	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974001759	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
891974001760	catalytic residue [active]
891974001761	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
891974001762	putative acyl-acceptor binding pocket; other site
891974001763	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
891974001764	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391
891974001765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974001766	S-adenosylmethionine binding site [chemical binding]; other site
891974001767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974001768	Protein of unknown function DUF262; Region: DUF262; pfam03235
891974001769	integrase; Provisional; Region: PRK09692
891974001770	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
891974001771	active site
891974001772	Int/Topo IB signature motif; other site
891974001773	hypothetical protein; Provisional; Region: PRK11820
891974001774	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
891974001775	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
891974001776	Fimbrial protein; Region: Fimbrial; cl01416
891974001777	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
891974001778	PapC N-terminal domain; Region: PapC_N; pfam13954
891974001779	PapC N-terminal domain; Region: PapC_N; pfam13954
891974001780	PapC N-terminal domain; Region: PapC_N; pfam13954
891974001781	Outer membrane usher protein; Region: Usher; pfam00577
891974001782	Outer membrane usher protein; Region: Usher; pfam00577
891974001783	PapC C-terminal domain; Region: PapC_C; pfam13953
891974001784	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
891974001785	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
891974001786	Fimbrial protein; Region: Fimbrial; cl01416
891974001787	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
891974001788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
891974001789	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
891974001790	DNA binding site [nucleotide binding]
891974001791	Fimbrial protein; Region: Fimbrial; pfam00419
891974001792	Fimbrial protein; Region: Fimbrial; pfam00419
891974001793	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
891974001794	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
891974001795	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
891974001796	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
891974001797	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
891974001798	RNA binding site [nucleotide binding]; other site
891974001799	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
891974001800	oligomer interface [polypeptide binding]; other site
891974001801	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974001802	active site
891974001803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974001804	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974001805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974001806	Transposase; Region: HTH_Tnp_1; cl17663
891974001807	Integrase core domain; Region: rve; pfam00665
891974001808	Integrase core domain; Region: rve_3; pfam13683
891974001809	Methyltransferase domain; Region: Methyltransf_27; pfam13708
891974001810	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
891974001811	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974001812	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974001813	dimerization interface [polypeptide binding]; other site
891974001814	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974001815	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974001816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001817	putative substrate translocation pore; other site
891974001818	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974001819	Mor transcription activator family; Region: Mor; pfam08765
891974001820	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974001821	LysE type translocator; Region: LysE; cl00565
891974001822	LysE type translocator; Region: LysE; cl00565
891974001823	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974001824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974001825	non-specific DNA binding site [nucleotide binding]; other site
891974001826	salt bridge; other site
891974001827	sequence-specific DNA binding site [nucleotide binding]; other site
891974001828	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974001829	AAA domain; Region: AAA_22; pfam13401
891974001830	Integrase core domain; Region: rve; pfam00665
891974001831	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974001832	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
891974001833	Transcriptional regulator; Region: Rrf2; cl17282
891974001834	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974001835	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974001836	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974001837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974001838	non-specific DNA binding site [nucleotide binding]; other site
891974001839	salt bridge; other site
891974001840	sequence-specific DNA binding site [nucleotide binding]; other site
891974001841	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
891974001842	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
891974001843	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974001844	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974001845	catalytic residue [active]
891974001846	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974001847	Phage Terminase; Region: Terminase_1; cl19862
891974001848	Terminase-like family; Region: Terminase_6; pfam03237
891974001849	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974001850	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974001851	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974001852	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974001853	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
891974001854	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
891974001855	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974001856	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974001857	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974001858	seadornavirus RNA-directed RNA polymerase; Region: seadorna_RNAP; TIGR04234
891974001859	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974001860	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974001861	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974001862	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974001863	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974001864	catalytic residues [active]
891974001865	catalytic nucleophile [active]
891974001866	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974001867	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974001868	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974001869	Synaptic Site I dimer interface [polypeptide binding]; other site
891974001870	DNA binding site [nucleotide binding]
891974001871	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974001872	DNA-binding interface [nucleotide binding]; DNA binding site
891974001873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974001874	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974001875	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
891974001876	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974001877	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974001878	conserved cys residue [active]
891974001879	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
891974001880	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
891974001881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974001882	putative substrate translocation pore; other site
891974001883	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
891974001884	Sensors of blue-light using FAD; Region: BLUF; pfam04940
891974001885	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974001886	Domain of unknown function DUF20; Region: UPF0118; cl00465
891974001887	Domain of unknown function DUF20; Region: UPF0118; cl00465
891974001888	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
891974001889	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
891974001890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974001891	active site
891974001892	motif I; other site
891974001893	motif II; other site
891974001894	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974001895	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974001896	active site
891974001897	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974001898	fructuronate transporter; Provisional; Region: PRK10034; cl15264
891974001899	fructuronate transporter; Provisional; Region: PRK10034; cl15264
891974001900	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
891974001901	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
891974001902	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
891974001903	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
891974001904	DNA-binding site [nucleotide binding]; DNA binding site
891974001905	RNA-binding motif; other site
891974001906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974001907	Coenzyme A binding pocket [chemical binding]; other site
891974001908	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974001909	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
891974001910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974001911	homodimer interface [polypeptide binding]; other site
891974001912	catalytic residue [active]
891974001913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
891974001914	DNA-binding site [nucleotide binding]; DNA binding site
891974001915	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
891974001916	putative active site [active]
891974001917	catalytic triad [active]
891974001918	putative dimer interface [polypeptide binding]; other site
891974001919	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974001920	substrate binding pocket [chemical binding]; other site
891974001921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974001922	membrane-bound complex binding site; other site
891974001923	hinge residues; other site
891974001924	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974001925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001926	dimer interface [polypeptide binding]; other site
891974001927	ABC-ATPase subunit interface; other site
891974001928	putative PBP binding loops; other site
891974001929	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974001930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001931	Walker A/P-loop; other site
891974001932	ATP binding site [chemical binding]; other site
891974001933	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974001934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001935	Q-loop/lid; other site
891974001936	ABC transporter signature motif; other site
891974001937	Walker B; other site
891974001938	D-loop; other site
891974001939	H-loop/switch region; other site
891974001940	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974001941	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
891974001942	lipoyl synthase; Provisional; Region: PRK05481
891974001943	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974001944	FeS/SAM binding site; other site
891974001945	lipoate-protein ligase B; Provisional; Region: PRK14342
891974001946	hypothetical protein; Provisional; Region: PRK04998
891974001947	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
891974001948	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974001949	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
891974001950	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974001951	rare lipoprotein A; Provisional; Region: PRK10672
891974001952	Uncharacterized lipoprotein; Region: Lipoprotein_16; cl19472
891974001953	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
891974001954	Sporulation related domain; Region: SPOR; pfam05036
891974001955	cell wall shape-determining protein; Provisional; Region: PRK10794
891974001956	penicillin-binding protein 2; Provisional; Region: PRK10795
891974001957	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
891974001958	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
891974001959	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
891974001960	Oligomerization domain; Region: Oligomerization; cl00519
891974001961	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
891974001962	active site
891974001963	(T/H)XGH motif; other site
891974001964	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
891974001965	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
891974001966	Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840
891974001967	Lipopolysaccharide-assembly; Region: LptE; cl01125
891974001968	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
891974001969	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
891974001970	active site
891974001971	KMSKS motif; other site
891974001972	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
891974001973	tRNA binding surface [nucleotide binding]; other site
891974001974	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
891974001975	HIGH motif; other site
891974001976	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
891974001977	Protein of unknown function (DUF1451); Region: DUF1451; cl19727
891974001978	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974001979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974001980	Walker A/P-loop; other site
891974001981	ATP binding site [chemical binding]; other site
891974001982	Q-loop/lid; other site
891974001983	ABC transporter signature motif; other site
891974001984	Walker B; other site
891974001985	D-loop; other site
891974001986	H-loop/switch region; other site
891974001987	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974001988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001989	dimer interface [polypeptide binding]; other site
891974001990	conserved gate region; other site
891974001991	putative PBP binding loops; other site
891974001992	ABC-ATPase subunit interface; other site
891974001993	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974001994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974001995	dimer interface [polypeptide binding]; other site
891974001996	conserved gate region; other site
891974001997	putative PBP binding loops; other site
891974001998	ABC-ATPase subunit interface; other site
891974001999	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002000	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
891974002001	membrane-bound complex binding site; other site
891974002002	hinge residues; other site
891974002003	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002004	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
891974002005	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
891974002006	putative active site [active]
891974002007	catalytic triad [active]
891974002008	putative dimer interface [polypeptide binding]; other site
891974002009	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
891974002010	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
891974002011	Transporter associated domain; Region: CorC_HlyC; smart01091
891974002012	metal-binding heat shock protein; Provisional; Region: PRK00016
891974002013	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
891974002014	PhoH-like protein; Region: PhoH; pfam02562
891974002015	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
891974002016	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
891974002017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974002018	FeS/SAM binding site; other site
891974002019	TRAM domain; Region: TRAM; pfam01938
891974002020	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
891974002021	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
891974002022	asparagine synthetase B; Provisional; Region: asnB; PRK09431
891974002023	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
891974002024	active site
891974002025	dimer interface [polypeptide binding]; other site
891974002026	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
891974002027	Ligand Binding Site [chemical binding]; other site
891974002028	Molecular Tunnel; other site
891974002029	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
891974002030	UMP phosphatase; Provisional; Region: PRK10444
891974002031	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974002032	active site
891974002033	motif I; other site
891974002034	motif II; other site
891974002035	MarR family; Region: MarR_2; cl17246
891974002036	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974002037	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974002038	nucleotide binding site [chemical binding]; other site
891974002039	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974002040	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
891974002041	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
891974002042	active site
891974002043	dimer interface [polypeptide binding]; other site
891974002044	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
891974002045	active site
891974002046	trimer interface [polypeptide binding]; other site
891974002047	allosteric site; other site
891974002048	active site lid [active]
891974002049	hexamer (dimer of trimers) interface [polypeptide binding]; other site
891974002050	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974002051	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974002052	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
891974002053	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974002054	active site turn [active]
891974002055	phosphorylation site [posttranslational modification]
891974002056	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
891974002057	HPr interaction site; other site
891974002058	glycerol kinase (GK) interaction site [polypeptide binding]; other site
891974002059	active site
891974002060	phosphorylation site [posttranslational modification]
891974002061	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
891974002062	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
891974002063	active site
891974002064	HIGH motif; other site
891974002065	KMSKS motif; other site
891974002066	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
891974002067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
891974002068	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
891974002069	metal binding site 2 [ion binding]; metal-binding site
891974002070	putative DNA binding helix; other site
891974002071	metal binding site 1 [ion binding]; metal-binding site
891974002072	dimer interface [polypeptide binding]; other site
891974002073	structural Zn2+ binding site [ion binding]; other site
891974002074	flavodoxin FldA; Validated; Region: PRK09267
891974002075	LexA regulated protein; Provisional; Region: PRK11675
891974002076	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974002077	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
891974002078	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974002079	replication initiation regulator SeqA; Provisional; Region: PRK11187
891974002080	phosphoglucomutase; Validated; Region: PRK07564
891974002081	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
891974002082	active site
891974002083	substrate binding site [chemical binding]; other site
891974002084	metal binding site [ion binding]; metal-binding site
891974002085	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
891974002086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974002087	active site
891974002088	phosphorylation site [posttranslational modification]
891974002089	intermolecular recognition site; other site
891974002090	dimerization interface [polypeptide binding]; other site
891974002091	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974002092	DNA binding site [nucleotide binding]
891974002093	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
891974002094	Protein of unknown function (DUF523); Region: DUF523; pfam04463
891974002095	Uncharacterized conserved protein [Function unknown]; Region: COG3272
891974002096	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
891974002097	DNA photolyase; Region: DNA_photolyase; pfam00875
891974002098	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
891974002099	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
891974002100	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
891974002101	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
891974002102	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
891974002103	LamB/YcsF family protein; Provisional; Region: PRK05406
891974002104	Protein of unknown function (DUF969); Region: DUF969; cl01573
891974002105	Protein of unknown function (DUF969); Region: DUF969; cl01573
891974002106	Protein of unknown function (DUF979); Region: DUF979; cl19737
891974002107	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
891974002108	putative substrate binding pocket [chemical binding]; other site
891974002109	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
891974002110	AC domain interface; other site
891974002111	putative substrate binding pocket [chemical binding]; other site
891974002112	catalytic triad [active]
891974002113	interchain disulfide; other site
891974002114	endonuclease VIII; Provisional; Region: PRK10445
891974002115	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
891974002116	DNA binding site [nucleotide binding]
891974002117	catalytic residue [active]
891974002118	H2TH interface [polypeptide binding]; other site
891974002119	putative catalytic residues [active]
891974002120	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
891974002121	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
891974002122	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
891974002123	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
891974002124	dimer interface [polypeptide binding]; other site
891974002125	active site
891974002126	citrylCoA binding site [chemical binding]; other site
891974002127	NADH binding [chemical binding]; other site
891974002128	cationic pore residues; other site
891974002129	oxalacetate/citrate binding site [chemical binding]; other site
891974002130	coenzyme A binding site [chemical binding]; other site
891974002131	catalytic triad [active]
891974002132	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
891974002133	Iron-sulfur protein interface; other site
891974002134	proximal quinone binding site [chemical binding]; other site
891974002135	SdhD (CybS) interface [polypeptide binding]; other site
891974002136	proximal heme binding site [chemical binding]; other site
891974002137	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
891974002138	SdhC subunit interface [polypeptide binding]; other site
891974002139	proximal heme binding site [chemical binding]; other site
891974002140	cardiolipin binding site; other site
891974002141	Iron-sulfur protein interface; other site
891974002142	proximal quinone binding site [chemical binding]; other site
891974002143	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
891974002144	L-aspartate oxidase; Provisional; Region: PRK06175
891974002145	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
891974002146	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
891974002147	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
891974002148	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
891974002149	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
891974002150	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
891974002151	TPP-binding site [chemical binding]; other site
891974002152	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
891974002153	dimer interface [polypeptide binding]; other site
891974002154	PYR/PP interface [polypeptide binding]; other site
891974002155	TPP binding site [chemical binding]; other site
891974002156	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
891974002157	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
891974002158	E3 interaction surface; other site
891974002159	lipoyl attachment site [posttranslational modification]; other site
891974002160	e3 binding domain; Region: E3_binding; pfam02817
891974002161	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
891974002162	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
891974002163	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
891974002164	CoA-ligase; Region: Ligase_CoA; pfam00549
891974002165	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
891974002166	CoA binding domain; Region: CoA_binding; pfam02629
891974002167	CoA-ligase; Region: Ligase_CoA; pfam00549
891974002168	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
891974002169	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
891974002170	Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219
891974002171	Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219
891974002172	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
891974002173	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
891974002174	hypothetical protein; Provisional; Region: PRK10588
891974002175	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
891974002176	active site
891974002177	colicin uptake protein TolQ; Provisional; Region: PRK10801
891974002178	colicin uptake protein TolR; Provisional; Region: PRK11024
891974002179	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
891974002180	TolA C-terminal; Region: TolA; pfam06519
891974002181	translocation protein TolB; Provisional; Region: tolB; PRK03629
891974002182	TolB amino-terminal domain; Region: TolB_N; pfam04052
891974002183	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
891974002184	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
891974002185	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
891974002186	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
891974002187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974002188	ligand binding site [chemical binding]; other site
891974002189	tol-pal system protein YbgF; Provisional; Region: PRK10803
891974002190	Tetratricopeptide repeat; Region: TPR_6; pfam13174
891974002191	Tetratricopeptide repeat; Region: TPR_6; pfam13174
891974002192	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
891974002193	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
891974002194	minor groove reading motif; other site
891974002195	helix-hairpin-helix signature motif; other site
891974002196	substrate binding pocket [chemical binding]; other site
891974002197	active site
891974002198	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
891974002199	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
891974002200	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974002201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974002202	AlkA N-terminal domain; Region: AlkA_N; pfam06029
891974002203	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
891974002204	DNA binding site [nucleotide binding]
891974002205	active site
891974002206	quinolinate synthetase; Provisional; Region: PRK09375
891974002207	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
891974002208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002209	Cation efflux family; Region: Cation_efflux; cl00316
891974002210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
891974002211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974002212	active site
891974002213	phosphorylation site [posttranslational modification]
891974002214	intermolecular recognition site; other site
891974002215	dimerization interface [polypeptide binding]; other site
891974002216	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974002217	DNA binding residues [nucleotide binding]
891974002218	dimerization interface [polypeptide binding]; other site
891974002219	YbgS-like protein; Region: YbgS; pfam13985
891974002220	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
891974002221	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
891974002222	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
891974002223	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
891974002224	catalytic core [active]
891974002225	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
891974002226	active site
891974002227	catalytic residues [active]
891974002228	galactokinase; Provisional; Region: PRK05101
891974002229	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
891974002230	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
891974002231	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
891974002232	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
891974002233	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
891974002234	dimer interface [polypeptide binding]; other site
891974002235	active site
891974002236	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002237	Walker B; other site
891974002238	D-loop; other site
891974002239	H-loop/switch region; other site
891974002240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002241	Walker A/P-loop; other site
891974002242	ATP binding site [chemical binding]; other site
891974002243	Q-loop/lid; other site
891974002244	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
891974002245	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
891974002246	TOBE domain; Region: TOBE; cl01440
891974002247	TOBE domain; Region: TOBE; cl01440
891974002248	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
891974002249	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974002250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002251	dimer interface [polypeptide binding]; other site
891974002252	conserved gate region; other site
891974002253	ABC-ATPase subunit interface; other site
891974002254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974002255	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
891974002256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002257	Walker A/P-loop; other site
891974002258	ATP binding site [chemical binding]; other site
891974002259	Q-loop/lid; other site
891974002260	ABC transporter signature motif; other site
891974002261	Walker B; other site
891974002262	D-loop; other site
891974002263	H-loop/switch region; other site
891974002264	TOBE domain; Region: TOBE; cl01440
891974002265	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
891974002266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974002267	active site
891974002268	motif I; other site
891974002269	motif II; other site
891974002270	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974002271	6-phosphogluconolactonase; Provisional; Region: PRK11028
891974002272	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
891974002273	substrate binding site [chemical binding]; other site
891974002274	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974002275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974002276	inhibitor-cofactor binding pocket; inhibition site
891974002277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974002278	catalytic residue [active]
891974002279	biotin synthase; Provisional; Region: PRK15108
891974002280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974002281	FeS/SAM binding site; other site
891974002282	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
891974002283	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
891974002284	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
891974002285	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974002286	catalytic residue [active]
891974002287	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
891974002288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974002289	S-adenosylmethionine binding site [chemical binding]; other site
891974002290	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
891974002291	AAA domain; Region: AAA_26; pfam13500
891974002292	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
891974002293	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002294	Walker A/P-loop; other site
891974002295	ATP binding site [chemical binding]; other site
891974002296	Q-loop/lid; other site
891974002297	ABC transporter signature motif; other site
891974002298	Walker B; other site
891974002299	D-loop; other site
891974002300	H-loop/switch region; other site
891974002301	excinuclease ABC subunit B; Provisional; Region: PRK05298
891974002302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974002303	ATP binding site [chemical binding]; other site
891974002304	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974002305	nucleotide binding region [chemical binding]; other site
891974002306	ATP-binding site [chemical binding]; other site
891974002307	Ultra-violet resistance protein B; Region: UvrB; pfam12344
891974002308	UvrB/uvrC motif; Region: UVR; pfam02151
891974002309	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
891974002310	dimer interface [polypeptide binding]; other site
891974002311	phosphate binding site [ion binding]; other site
891974002312	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
891974002313	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
891974002314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974002315	FeS/SAM binding site; other site
891974002316	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
891974002317	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
891974002318	MPT binding site; other site
891974002319	trimer interface [polypeptide binding]; other site
891974002320	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
891974002321	trimer interface [polypeptide binding]; other site
891974002322	dimer interface [polypeptide binding]; other site
891974002323	putative active site [active]
891974002324	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
891974002325	MoaE interaction surface [polypeptide binding]; other site
891974002326	MoeB interaction surface [polypeptide binding]; other site
891974002327	thiocarboxylated glycine; other site
891974002328	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
891974002329	MoaE homodimer interface [polypeptide binding]; other site
891974002330	MoaD interaction [polypeptide binding]; other site
891974002331	active site residues [active]
891974002332	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
891974002333	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
891974002334	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
891974002335	Predicted integral membrane protein [Function unknown]; Region: COG0392
891974002336	cardiolipin synthase 2; Provisional; Region: PRK11263
891974002337	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
891974002338	putative active site [active]
891974002339	catalytic site [active]
891974002340	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
891974002341	putative active site [active]
891974002342	catalytic site [active]
891974002343	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
891974002344	putative catalytic site [active]
891974002345	putative phosphate binding site [ion binding]; other site
891974002346	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
891974002347	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
891974002348	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
891974002349	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
891974002350	ATP binding site [chemical binding]; other site
891974002351	Mg++ binding site [ion binding]; other site
891974002352	motif III; other site
891974002353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974002354	nucleotide binding region [chemical binding]; other site
891974002355	ATP-binding site [chemical binding]; other site
891974002356	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
891974002357	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
891974002358	FMN binding site [chemical binding]; other site
891974002359	active site
891974002360	catalytic residues [active]
891974002361	substrate binding site [chemical binding]; other site
891974002362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974002363	putative substrate translocation pore; other site
891974002364	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
891974002365	oligomer interface [polypeptide binding]; other site
891974002366	L,D-transpeptidase; Provisional; Region: PRK10260
891974002367	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
891974002368	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
891974002369	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
891974002370	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
891974002371	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
891974002372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974002373	oxidoreductase; Provisional; Region: PRK12743
891974002374	NAD(P) binding site [chemical binding]; other site
891974002375	active site
891974002376	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
891974002377	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
891974002378	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974002379	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
891974002380	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974002381	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
891974002382	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974002383	D-lactate dehydrogenase; Provisional; Region: PRK11183
891974002384	FAD binding domain; Region: FAD_binding_4; cl19922
891974002385	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
891974002386	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
891974002387	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
891974002388	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
891974002389	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
891974002390	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
891974002391	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
891974002392	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
891974002393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974002394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974002395	dimerization interface [polypeptide binding]; other site
891974002396	Cache domain; Region: Cache_1; pfam02743
891974002397	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
891974002398	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
891974002399	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974002400	dimer interface [polypeptide binding]; other site
891974002401	putative CheW interface [polypeptide binding]; other site
891974002402	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
891974002403	active site
891974002404	metal binding site [ion binding]; metal-binding site
891974002405	nudix motif; other site
891974002406	benzoate transport; Region: 2A0115; TIGR00895
891974002407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974002408	putative substrate translocation pore; other site
891974002409	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974002410	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974002411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974002412	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
891974002413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002414	Q-loop/lid; other site
891974002415	ABC transporter signature motif; other site
891974002416	Walker B; other site
891974002417	D-loop; other site
891974002418	H-loop/switch region; other site
891974002419	CBS domain; Region: CBS; pfam00571
891974002420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002421	putative PBP binding loops; other site
891974002422	ABC-ATPase subunit interface; other site
891974002423	transcriptional regulator MirA; Provisional; Region: PRK15043
891974002424	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
891974002425	DNA binding residues [nucleotide binding]
891974002426	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974002427	non-specific DNA binding site [nucleotide binding]; other site
891974002428	salt bridge; other site
891974002429	sequence-specific DNA binding site [nucleotide binding]; other site
891974002430	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
891974002431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974002432	Coenzyme A binding pocket [chemical binding]; other site
891974002433	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974002434	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974002435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974002436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974002437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974002438	dimerization interface [polypeptide binding]; other site
891974002439	argininosuccinate lyase; Provisional; Region: PRK00855
891974002440	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
891974002441	active sites [active]
891974002442	tetramer interface [polypeptide binding]; other site
891974002443	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974002444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002445	dimer interface [polypeptide binding]; other site
891974002446	conserved gate region; other site
891974002447	putative PBP binding loops; other site
891974002448	ABC-ATPase subunit interface; other site
891974002449	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
891974002450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002451	Walker A/P-loop; other site
891974002452	ATP binding site [chemical binding]; other site
891974002453	Q-loop/lid; other site
891974002454	ABC transporter signature motif; other site
891974002455	Walker B; other site
891974002456	D-loop; other site
891974002457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002459	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974002460	substrate binding pocket [chemical binding]; other site
891974002461	membrane-bound complex binding site; other site
891974002462	hinge residues; other site
891974002463	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
891974002464	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
891974002465	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
891974002466	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974002467	active site
891974002468	NAD binding site [chemical binding]; other site
891974002469	metal binding site [ion binding]; metal-binding site
891974002470	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
891974002471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
891974002472	dimerization interface [polypeptide binding]; other site
891974002473	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
891974002474	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
891974002475	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
891974002476	glycosyl transferase family protein; Provisional; Region: PRK08136
891974002477	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
891974002478	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
891974002479	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
891974002480	metal binding site [ion binding]; metal-binding site
891974002481	putative dimer interface [polypeptide binding]; other site
891974002482	urocanate hydratase; Provisional; Region: PRK05414
891974002483	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
891974002484	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
891974002485	active sites [active]
891974002486	tetramer interface [polypeptide binding]; other site
891974002487	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
891974002488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974002489	DNA-binding site [nucleotide binding]; DNA binding site
891974002490	UTRA domain; Region: UTRA; pfam07702
891974002491	HutD; Region: HutD; cl01532
891974002492	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974002493	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
891974002494	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974002495	active site
891974002496	imidazolonepropionase; Validated; Region: PRK09356
891974002497	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
891974002498	active site
891974002499	N-formylglutamate amidohydrolase; Region: FGase; cl01522
891974002500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002501	dimer interface [polypeptide binding]; other site
891974002502	conserved gate region; other site
891974002503	putative PBP binding loops; other site
891974002504	ABC-ATPase subunit interface; other site
891974002505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002506	Walker A/P-loop; other site
891974002507	ATP binding site [chemical binding]; other site
891974002508	Q-loop/lid; other site
891974002509	ABC transporter signature motif; other site
891974002510	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974002511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002512	Walker B; other site
891974002513	D-loop; other site
891974002514	H-loop/switch region; other site
891974002515	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
891974002516	active sites [active]
891974002517	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
891974002518	tetramer interface [polypeptide binding]; other site
891974002519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974002520	S-adenosylmethionine binding site [chemical binding]; other site
891974002521	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
891974002522	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974002523	Walker A/P-loop; other site
891974002524	ATP binding site [chemical binding]; other site
891974002525	Q-loop/lid; other site
891974002526	ABC transporter signature motif; other site
891974002527	Walker B; other site
891974002528	D-loop; other site
891974002529	H-loop/switch region; other site
891974002530	glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494
891974002531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002532	dimer interface [polypeptide binding]; other site
891974002533	conserved gate region; other site
891974002534	putative PBP binding loops; other site
891974002535	ABC-ATPase subunit interface; other site
891974002536	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
891974002537	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002538	substrate binding pocket [chemical binding]; other site
891974002539	membrane-bound complex binding site; other site
891974002540	hinge residues; other site
891974002541	DNA starvation/stationary phase protection protein Dps; Provisional; Region: PRK09448
891974002542	DNA starvation/stationary phase protection protein Dps; Provisional; Region: PRK09448
891974002543	Ferritin-like domain; Region: Ferritin; pfam00210
891974002544	threonine and homoserine efflux system; Provisional; Region: PRK10532
891974002545	EamA-like transporter family; Region: EamA; pfam00892
891974002546	outer membrane protein X; Provisional; Region: ompX; PRK09408
891974002547	manganese transport regulator MntR; Provisional; Region: PRK11050
891974002548	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
891974002549	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
891974002550	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
891974002551	transmembrane helices; other site
891974002552	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
891974002553	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
891974002554	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974002555	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
891974002556	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974002557	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
891974002558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974002559	putative substrate translocation pore; other site
891974002560	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
891974002561	Outer membrane efflux protein; Region: OEP; pfam02321
891974002562	Outer membrane efflux protein; Region: OEP; pfam02321
891974002563	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
891974002564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974002565	putative substrate translocation pore; other site
891974002566	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
891974002567	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
891974002568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002569	Walker A/P-loop; other site
891974002570	ATP binding site [chemical binding]; other site
891974002571	Q-loop/lid; other site
891974002572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002573	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974002574	ABC transporter; Region: ABC_tran_2; pfam12848
891974002575	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974002576	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
891974002577	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
891974002578	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
891974002579	ATP binding site [chemical binding]; other site
891974002580	substrate interface [chemical binding]; other site
891974002581	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
891974002582	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
891974002583	dimer interface [polypeptide binding]; other site
891974002584	putative functional site; other site
891974002585	putative MPT binding site; other site
891974002586	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
891974002587	catalytic nucleophile [active]
891974002588	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
891974002589	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974002590	Walker A/P-loop; other site
891974002591	ATP binding site [chemical binding]; other site
891974002592	Q-loop/lid; other site
891974002593	ABC transporter signature motif; other site
891974002594	Walker B; other site
891974002595	D-loop; other site
891974002596	H-loop/switch region; other site
891974002597	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974002598	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974002599	Walker A/P-loop; other site
891974002600	ATP binding site [chemical binding]; other site
891974002601	Q-loop/lid; other site
891974002602	ABC transporter signature motif; other site
891974002603	Walker B; other site
891974002604	D-loop; other site
891974002605	H-loop/switch region; other site
891974002606	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974002607	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974002608	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
891974002609	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
891974002610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002611	dimer interface [polypeptide binding]; other site
891974002612	conserved gate region; other site
891974002613	putative PBP binding loops; other site
891974002614	ABC-ATPase subunit interface; other site
891974002615	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
891974002616	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974002617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002618	dimer interface [polypeptide binding]; other site
891974002619	conserved gate region; other site
891974002620	putative PBP binding loops; other site
891974002621	ABC-ATPase subunit interface; other site
891974002622	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974002623	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974002624	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974002625	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974002626	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974002627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974002628	dimer interface [polypeptide binding]; other site
891974002629	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
891974002630	putative CheW interface [polypeptide binding]; other site
891974002631	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
891974002632	dimer interface [polypeptide binding]; other site
891974002633	ligand binding site [chemical binding]; other site
891974002634	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974002635	dimerization interface [polypeptide binding]; other site
891974002636	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
891974002637	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
891974002638	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
891974002639	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974002640	Radical SAM superfamily; Region: Radical_SAM; pfam04055
891974002641	FeS/SAM binding site; other site
891974002642	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
891974002643	active site clefts [active]
891974002644	zinc binding site [ion binding]; other site
891974002645	dimer interface [polypeptide binding]; other site
891974002646	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
891974002647	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
891974002648	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
891974002649	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
891974002650	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974002651	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974002652	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
891974002653	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
891974002654	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
891974002655	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
891974002656	active site
891974002657	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
891974002658	active site
891974002659	putative transporter; Provisional; Region: PRK04972
891974002660	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
891974002661	TrkA-C domain; Region: TrkA_C; pfam02080
891974002662	TrkA-C domain; Region: TrkA_C; pfam02080
891974002663	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
891974002664	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
891974002665	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
891974002666	GSH binding site [chemical binding]; other site
891974002667	catalytic residues [active]
891974002668	Protein of unknown function (DUF1418); Region: DUF1418; cl11648
891974002669	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
891974002670	dimer interface [polypeptide binding]; other site
891974002671	FMN binding site [chemical binding]; other site
891974002672	NADPH bind site [chemical binding]; other site
891974002673	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
891974002674	RimK-like ATP-grasp domain; Region: RimK; pfam08443
891974002675	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
891974002676	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974002677	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974002678	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
891974002679	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002680	Walker A/P-loop; other site
891974002681	ATP binding site [chemical binding]; other site
891974002682	Q-loop/lid; other site
891974002683	ABC transporter signature motif; other site
891974002684	Walker B; other site
891974002685	D-loop; other site
891974002686	H-loop/switch region; other site
891974002687	TOBE domain; Region: TOBE_2; pfam08402
891974002688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002689	dimer interface [polypeptide binding]; other site
891974002690	conserved gate region; other site
891974002691	putative PBP binding loops; other site
891974002692	ABC-ATPase subunit interface; other site
891974002693	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
891974002694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002695	dimer interface [polypeptide binding]; other site
891974002696	conserved gate region; other site
891974002697	putative PBP binding loops; other site
891974002698	ABC-ATPase subunit interface; other site
891974002699	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
891974002700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974002701	Methyltransferase domain; Region: Methyltransf_31; pfam13847
891974002702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974002703	S-adenosylmethionine binding site [chemical binding]; other site
891974002704	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
891974002705	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002706	substrate binding pocket [chemical binding]; other site
891974002707	membrane-bound complex binding site; other site
891974002708	hinge residues; other site
891974002709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974002710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002711	putative PBP binding loops; other site
891974002712	dimer interface [polypeptide binding]; other site
891974002713	ABC-ATPase subunit interface; other site
891974002714	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
891974002715	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002716	substrate binding pocket [chemical binding]; other site
891974002717	membrane-bound complex binding site; other site
891974002718	hinge residues; other site
891974002719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002720	ABC transporter signature motif; other site
891974002721	Walker B; other site
891974002722	D-loop; other site
891974002723	H-loop/switch region; other site
891974002724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002725	Walker A/P-loop; other site
891974002726	ATP binding site [chemical binding]; other site
891974002727	Q-loop/lid; other site
891974002728	putative lipoprotein; Provisional; Region: PRK10533
891974002729	hypothetical protein; Provisional; Region: PRK02877
891974002730	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
891974002731	substrate binding site [chemical binding]; other site
891974002732	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
891974002733	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
891974002734	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
891974002735	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974002736	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974002737	catalytic residue [active]
891974002738	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974002739	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974002740	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
891974002741	TPP-binding site [chemical binding]; other site
891974002742	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
891974002743	PYR/PP interface [polypeptide binding]; other site
891974002744	dimer interface [polypeptide binding]; other site
891974002745	TPP binding site [chemical binding]; other site
891974002746	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
891974002747	putative active site [active]
891974002748	putative metal-binding site [ion binding]; other site
891974002749	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
891974002750	DNA-binding site [nucleotide binding]; DNA binding site
891974002751	RNA-binding motif; other site
891974002752	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
891974002753	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
891974002754	Clp amino terminal domain; Region: Clp_N; pfam02861
891974002755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974002756	Walker A motif; other site
891974002757	ATP binding site [chemical binding]; other site
891974002758	Walker B motif; other site
891974002759	arginine finger; other site
891974002760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974002761	Walker A motif; other site
891974002762	ATP binding site [chemical binding]; other site
891974002763	Walker B motif; other site
891974002764	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
891974002765	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
891974002766	rRNA binding site [nucleotide binding]; other site
891974002767	predicted 30S ribosome binding site; other site
891974002768	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
891974002769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002770	H-loop/switch region; other site
891974002771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002772	Walker A/P-loop; other site
891974002773	ATP binding site [chemical binding]; other site
891974002774	Q-loop/lid; other site
891974002775	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
891974002776	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002777	H-loop/switch region; other site
891974002778	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974002779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974002780	Walker A/P-loop; other site
891974002781	ATP binding site [chemical binding]; other site
891974002782	thioredoxin reductase; Provisional; Region: PRK10262
891974002783	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974002784	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974002785	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
891974002786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974002787	putative DNA binding site [nucleotide binding]; other site
891974002788	putative Zn2+ binding site [ion binding]; other site
891974002789	AsnC family; Region: AsnC_trans_reg; pfam01037
891974002790	DNA translocase FtsK; Provisional; Region: PRK10263
891974002791	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
891974002792	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
891974002793	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
891974002794	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
891974002795	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
891974002796	recombination factor protein RarA; Reviewed; Region: PRK13342
891974002797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974002798	Walker A motif; other site
891974002799	ATP binding site [chemical binding]; other site
891974002800	Walker B motif; other site
891974002801	arginine finger; other site
891974002802	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
891974002803	seryl-tRNA synthetase; Provisional; Region: PRK05431
891974002804	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
891974002805	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
891974002806	dimer interface [polypeptide binding]; other site
891974002807	active site
891974002808	motif 1; other site
891974002809	motif 2; other site
891974002810	motif 3; other site
891974002811	putative MFS family transporter protein; Provisional; Region: PRK03633
891974002812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974002813	putative substrate translocation pore; other site
891974002814	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
891974002815	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
891974002816	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
891974002817	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
891974002818	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
891974002819	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
891974002820	YcaO-like family; Region: YcaO; cl19253
891974002821	YcaO-like family; Region: YcaO; cl19253
891974002822	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
891974002823	homodimer interface [polypeptide binding]; other site
891974002824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974002825	substrate-cofactor binding pocket; other site
891974002826	catalytic residue [active]
891974002827	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
891974002828	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
891974002829	hinge; other site
891974002830	active site
891974002831	cytidylate kinase; Provisional; Region: cmk; PRK00023
891974002832	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
891974002833	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
891974002834	active site
891974002835	CMP-binding site; other site
891974002836	The sites determining sugar specificity; other site
891974002837	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
891974002838	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
891974002839	RNA binding site [nucleotide binding]; other site
891974002840	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
891974002841	RNA binding site [nucleotide binding]; other site
891974002842	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
891974002843	RNA binding site [nucleotide binding]; other site
891974002844	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
891974002845	RNA binding site [nucleotide binding]; other site
891974002846	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
891974002847	RNA binding site [nucleotide binding]; other site
891974002848	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
891974002849	RNA binding site [nucleotide binding]; other site
891974002850	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
891974002851	dimer interface [polypeptide binding]; other site
891974002852	DNA binding site [nucleotide binding]
891974002853	Competence protein; Region: Competence; pfam03772
891974002854	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
891974002855	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
891974002856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974002857	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
891974002858	Walker A/P-loop; other site
891974002859	ATP binding site [chemical binding]; other site
891974002860	Q-loop/lid; other site
891974002861	ABC transporter signature motif; other site
891974002862	Walker B; other site
891974002863	D-loop; other site
891974002864	H-loop/switch region; other site
891974002865	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
891974002866	Winged helix DNA-binding domain; Region: HTH_42; cl19833
891974002867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
891974002868	Winged helix DNA-binding domain; Region: HTH_42; cl19833
891974002869	Trm112p-like protein; Region: Trm112p; cl01066
891974002870	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
891974002871	Ligand binding site; other site
891974002872	oligomer interface; other site
891974002873	hypothetical protein; Provisional; Region: PRK10593
891974002874	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
891974002875	putative active site [active]
891974002876	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
891974002877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974002878	S-adenosylmethionine binding site [chemical binding]; other site
891974002879	condesin subunit F; Provisional; Region: PRK05260
891974002880	condesin subunit E; Provisional; Region: PRK05256
891974002881	cell division protein MukB; Provisional; Region: mukB; PRK04863
891974002882	P-loop containing region of AAA domain; Region: AAA_29; cl17516
891974002883	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
891974002884	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
891974002885	murein L,D-transpeptidase; Provisional; Region: PRK10594
891974002886	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
891974002887	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
891974002888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
891974002889	Peptidase M15; Region: Peptidase_M15_3; cl01194
891974002890	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
891974002891	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
891974002892	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974002893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974002894	homodimer interface [polypeptide binding]; other site
891974002895	catalytic residue [active]
891974002896	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
891974002897	trimer interface [polypeptide binding]; other site
891974002898	eyelet of channel; other site
891974002899	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
891974002900	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
891974002901	putative dimer interface [polypeptide binding]; other site
891974002902	putative anticodon binding site; other site
891974002903	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
891974002904	homodimer interface [polypeptide binding]; other site
891974002905	motif 1; other site
891974002906	motif 2; other site
891974002907	active site
891974002908	motif 3; other site
891974002909	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
891974002910	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
891974002911	active site
891974002912	aminopeptidase N; Provisional; Region: pepN; PRK14015
891974002913	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
891974002914	active site
891974002915	Zn binding site [ion binding]; other site
891974002916	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974002917	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974002918	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974002919	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974002920	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974002921	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
891974002922	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
891974002923	Walker A/P-loop; other site
891974002924	ATP binding site [chemical binding]; other site
891974002925	Q-loop/lid; other site
891974002926	ABC transporter signature motif; other site
891974002927	Walker B; other site
891974002928	D-loop; other site
891974002929	H-loop/switch region; other site
891974002930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974002931	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
891974002932	dimer interface [polypeptide binding]; other site
891974002933	ABC-ATPase subunit interface; other site
891974002934	putative PBP binding loops; other site
891974002935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974002936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974002937	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974002938	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974002939	substrate binding pocket [chemical binding]; other site
891974002940	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
891974002941	membrane-bound complex binding site; other site
891974002942	hinge residues; other site
891974002943	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
891974002944	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974002945	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974002946	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
891974002947	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974002948	active site
891974002949	putative glycosyl transferase; Provisional; Region: PRK10073
891974002950	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974002951	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
891974002952	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
891974002953	quinone interaction residues [chemical binding]; other site
891974002954	active site
891974002955	catalytic residues [active]
891974002956	FMN binding site [chemical binding]; other site
891974002957	substrate binding site [chemical binding]; other site
891974002958	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
891974002959	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974002960	catalytic loop [active]
891974002961	iron binding site [ion binding]; other site
891974002962	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
891974002963	MOSC domain; Region: MOSC; pfam03473
891974002964	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
891974002965	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
891974002966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974002967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974002968	S-adenosylmethionine binding site [chemical binding]; other site
891974002969	ABC transporter ATPase component; Reviewed; Region: PRK11147
891974002970	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974002971	ABC transporter; Region: ABC_tran_2; pfam12848
891974002972	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974002973	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
891974002974	Paraquat-inducible protein A; Region: PqiA; pfam04403
891974002975	Paraquat-inducible protein A; Region: PqiA; pfam04403
891974002976	paraquat-inducible protein B; Provisional; Region: PRK10807
891974002977	mce related protein; Region: MCE; pfam02470
891974002978	mce related protein; Region: MCE; pfam02470
891974002979	mce related protein; Region: MCE; pfam02470
891974002980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
891974002981	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
891974002982	active site 1 [active]
891974002983	dimer interface [polypeptide binding]; other site
891974002984	active site 2 [active]
891974002985	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
891974002986	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
891974002987	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
891974002988	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
891974002989	outer membrane protein A; Reviewed; Region: PRK10808
891974002990	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
891974002991	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974002992	ligand binding site [chemical binding]; other site
891974002993	SOS cell division inhibitor; Provisional; Region: PRK10595
891974002994	TfoX N-terminal domain; Region: TfoX_N; pfam04993
891974002995	TfoX C-terminal domain; Region: TfoX_C; pfam04994
891974002996	TIGR01666 family membrane protein; Region: YCCS
891974002997	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
891974002998	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
891974002999	hypothetical protein; Provisional; Region: PRK11770
891974003000	Domain of unknown function (DUF307); Region: DUF307; pfam03733
891974003001	Domain of unknown function (DUF307); Region: DUF307; pfam03733
891974003002	DNA helicase IV; Provisional; Region: helD; PRK11054
891974003003	DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462
891974003004	Part of AAA domain; Region: AAA_19; pfam13245
891974003005	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
891974003006	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
891974003007	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
891974003008	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
891974003009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003010	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
891974003011	putative RNA binding site [nucleotide binding]; other site
891974003012	Acylphosphatase; Region: Acylphosphatase; cl00551
891974003013	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
891974003014	YccA-like proteins; Region: YccA_like; cd10433
891974003015	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
891974003016	catalytic core [active]
891974003017	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
891974003018	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974003019	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974003020	NAD(P) binding site [chemical binding]; other site
891974003021	catalytic residues [active]
891974003022	YccJ-like protein; Region: YccJ; cl08091
891974003023	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
891974003024	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
891974003025	EamA-like transporter family; Region: EamA; pfam00892
891974003026	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974003027	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974003028	Protein of unknown function (DUF935); Region: DUF935; pfam06074
891974003029	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974003030	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
891974003031	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
891974003032	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
891974003033	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
891974003034	Gp37 protein; Region: Gp37; pfam09646
891974003035	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
891974003036	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
891974003037	Phage tail tube protein FII; Region: Phage_tube; cl01390
891974003038	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
891974003039	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
891974003040	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
891974003041	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
891974003042	Phage Tail Protein X; Region: Phage_tail_X; cl02088
891974003043	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974003044	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974003045	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
891974003046	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
891974003047	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974003048	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974003049	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974003050	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974003051	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974003052	catalytic residues [active]
891974003053	catalytic nucleophile [active]
891974003054	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974003055	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
891974003056	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974003057	DNA-binding interface [nucleotide binding]; DNA binding site
891974003058	fumarate hydratase; Provisional; Region: PRK15389
891974003059	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
891974003060	Fumarase C-terminus; Region: Fumerase_C; pfam05683
891974003061	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
891974003062	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
891974003063	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974003064	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974003065	phosphate binding site [ion binding]; other site
891974003066	FMN-binding domain; Region: FMN_bind; cl01081
891974003067	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
891974003068	L-aspartate oxidase; Provisional; Region: PRK06175
891974003069	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
891974003070	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
891974003071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974003072	active site
891974003073	phosphorylation site [posttranslational modification]
891974003074	intermolecular recognition site; other site
891974003075	dimerization interface [polypeptide binding]; other site
891974003076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974003077	ATP binding site [chemical binding]; other site
891974003078	Mg2+ binding site [ion binding]; other site
891974003079	G-X-G motif; other site
891974003080	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
891974003081	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
891974003082	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
891974003083	methionine sulfoxide reductase A; Provisional; Region: PRK14054
891974003084	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
891974003085	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974003086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974003087	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
891974003088	dimer interface [polypeptide binding]; other site
891974003089	catalytic residues [active]
891974003090	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974003091	glutathionine S-transferase; Provisional; Region: PRK10542
891974003092	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
891974003093	C-terminal domain interface [polypeptide binding]; other site
891974003094	GSH binding site (G-site) [chemical binding]; other site
891974003095	dimer interface [polypeptide binding]; other site
891974003096	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
891974003097	dimer interface [polypeptide binding]; other site
891974003098	N-terminal domain interface [polypeptide binding]; other site
891974003099	substrate binding pocket (H-site) [chemical binding]; other site
891974003100	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
891974003101	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974003102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974003103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974003104	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
891974003105	putative effector binding pocket; other site
891974003106	putative dimerization interface [polypeptide binding]; other site
891974003107	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
891974003108	Catalytic site [active]
891974003109	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
891974003110	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
891974003111	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
891974003112	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
891974003113	active site
891974003114	homotetramer interface [polypeptide binding]; other site
891974003115	transcriptional activator FlhD; Provisional; Region: PRK02909
891974003116	transcriptional activator FlhC; Provisional; Region: PRK12722
891974003117	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
891974003118	flagellar motor protein MotB; Validated; Region: motB; PRK09041
891974003119	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
891974003120	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974003121	ligand binding site [chemical binding]; other site
891974003122	CheY binding; Region: CheY-binding; pfam09078
891974003123	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
891974003124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974003125	ATP binding site [chemical binding]; other site
891974003126	Mg2+ binding site [ion binding]; other site
891974003127	G-X-G motif; other site
891974003128	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
891974003129	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
891974003130	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
891974003131	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
891974003132	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
891974003133	dimer interface [polypeptide binding]; other site
891974003134	ligand binding site [chemical binding]; other site
891974003135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974003136	dimerization interface [polypeptide binding]; other site
891974003137	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974003138	dimer interface [polypeptide binding]; other site
891974003139	putative CheW interface [polypeptide binding]; other site
891974003140	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
891974003141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974003142	intermolecular recognition site; other site
891974003143	active site
891974003144	dimerization interface [polypeptide binding]; other site
891974003145	CheB methylesterase; Region: CheB_methylest; pfam01339
891974003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974003147	active site
891974003148	phosphorylation site [posttranslational modification]
891974003149	intermolecular recognition site; other site
891974003150	dimerization interface [polypeptide binding]; other site
891974003151	chemotaxis regulator CheZ; Provisional; Region: PRK11166
891974003152	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
891974003153	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
891974003154	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974003155	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
891974003156	trimer interface [polypeptide binding]; other site
891974003157	eyelet of channel; other site
891974003158	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974003159	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974003160	inhibitor-cofactor binding pocket; inhibition site
891974003161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974003162	catalytic residue [active]
891974003163	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
891974003164	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
891974003165	NAD(P) binding site [chemical binding]; other site
891974003166	catalytic residues [active]
891974003167	succinylarginine dihydrolase; Provisional; Region: PRK13281
891974003168	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
891974003169	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
891974003170	putative active site [active]
891974003171	Zn binding site [ion binding]; other site
891974003172	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
891974003173	dimer interface [polypeptide binding]; other site
891974003174	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
891974003175	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
891974003176	GIY-YIG motif/motif A; other site
891974003177	active site
891974003178	catalytic site [active]
891974003179	putative DNA binding site [nucleotide binding]; other site
891974003180	metal binding site [ion binding]; metal-binding site
891974003181	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
891974003182	homodimer interface [polypeptide binding]; other site
891974003183	NAD binding pocket [chemical binding]; other site
891974003184	ATP binding pocket [chemical binding]; other site
891974003185	Mg binding site [ion binding]; other site
891974003186	active-site loop [active]
891974003187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003188	putative substrate translocation pore; other site
891974003189	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
891974003190	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
891974003191	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
891974003192	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
891974003193	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
891974003194	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
891974003195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974003196	motif II; other site
891974003197	YniB-like protein; Region: YniB; pfam14002
891974003198	Fructosamine kinase; Region: Fructosamin_kin; cl17579
891974003199	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
891974003200	active site
891974003201	ATP binding site [chemical binding]; other site
891974003202	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
891974003203	Protein of unknown function, DUF481; Region: DUF481; cl01213
891974003204	Protein of unknown function, DUF481; Region: DUF481; cl01213
891974003205	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
891974003206	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
891974003207	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
891974003208	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
891974003209	active site
891974003210	dimer interface [polypeptide binding]; other site
891974003211	motif 1; other site
891974003212	motif 2; other site
891974003213	motif 3; other site
891974003214	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
891974003215	anticodon binding site; other site
891974003216	translation initiation factor IF-3; Region: infC; TIGR00168
891974003217	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
891974003218	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
891974003219	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
891974003220	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
891974003221	23S rRNA binding site [nucleotide binding]; other site
891974003222	L21 binding site [polypeptide binding]; other site
891974003223	L13 binding site [polypeptide binding]; other site
891974003224	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
891974003225	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
891974003226	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
891974003227	dimer interface [polypeptide binding]; other site
891974003228	motif 1; other site
891974003229	active site
891974003230	motif 2; other site
891974003231	motif 3; other site
891974003232	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
891974003233	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
891974003234	putative tRNA-binding site [nucleotide binding]; other site
891974003235	B3/4 domain; Region: B3_4; pfam03483
891974003236	tRNA synthetase B5 domain; Region: B5; smart00874
891974003237	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
891974003238	dimer interface [polypeptide binding]; other site
891974003239	motif 1; other site
891974003240	motif 3; other site
891974003241	motif 2; other site
891974003242	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
891974003243	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
891974003244	DNA binding site [nucleotide binding]
891974003245	dimer interface [polypeptide binding]; other site
891974003246	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974003247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974003248	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974003249	putative PBP binding regions; other site
891974003250	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974003251	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974003252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974003253	Q-loop/lid; other site
891974003254	ABC transporter signature motif; other site
891974003255	Walker B; other site
891974003256	D-loop; other site
891974003257	H-loop/switch region; other site
891974003258	NlpC/P60 family; Region: NLPC_P60; pfam00877
891974003259	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
891974003260	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
891974003261	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
891974003262	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
891974003263	putative inner membrane protein; Provisional; Region: PRK10983
891974003264	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
891974003265	FAD binding domain; Region: FAD_binding_4; pfam01565
891974003266	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
891974003267	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
891974003268	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
891974003269	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
891974003270	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
891974003271	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
891974003272	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
891974003273	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
891974003274	Walker A/P-loop; other site
891974003275	ATP binding site [chemical binding]; other site
891974003276	Q-loop/lid; other site
891974003277	ABC transporter signature motif; other site
891974003278	Walker B; other site
891974003279	D-loop; other site
891974003280	H-loop/switch region; other site
891974003281	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
891974003282	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
891974003283	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
891974003284	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974003285	catalytic residue [active]
891974003286	cysteine desufuration protein SufE; Provisional; Region: PRK09296
891974003287	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974003288	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
891974003289	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
891974003290	murein lipoprotein; Provisional; Region: PRK15396
891974003291	pyruvate kinase; Provisional; Region: PRK09206
891974003292	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
891974003293	domain interfaces; other site
891974003294	active site
891974003295	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
891974003296	cation binding site [ion binding]; other site
891974003297	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974003298	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
891974003299	Lumazine binding domain; Region: Lum_binding; pfam00677
891974003300	Lumazine binding domain; Region: Lum_binding; pfam00677
891974003301	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
891974003302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003303	S-adenosylmethionine binding site [chemical binding]; other site
891974003304	putative transporter; Provisional; Region: PRK11043
891974003305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003306	putative substrate translocation pore; other site
891974003307	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974003308	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974003309	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
891974003310	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974003311	DNA binding site [nucleotide binding]
891974003312	domain linker motif; other site
891974003313	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
891974003314	dimerization interface [polypeptide binding]; other site
891974003315	ligand binding site [chemical binding]; other site
891974003316	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
891974003317	NlpC/P60 family; Region: NLPC_P60; pfam00877
891974003318	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
891974003319	putative GSH binding site [chemical binding]; other site
891974003320	catalytic residues [active]
891974003321	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
891974003322	ribonuclease T; Provisional; Region: PRK05168
891974003323	active site
891974003324	catalytic site [active]
891974003325	substrate binding site [chemical binding]; other site
891974003326	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
891974003327	dimer interface [polypeptide binding]; other site
891974003328	active site
891974003329	metal binding site [ion binding]; metal-binding site
891974003330	glutathione binding site [chemical binding]; other site
891974003331	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
891974003332	FMN binding site [chemical binding]; other site
891974003333	active site
891974003334	substrate binding site [chemical binding]; other site
891974003335	catalytic residue [active]
891974003336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974003337	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
891974003338	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
891974003339	P-class dimer interface [polypeptide binding]; other site
891974003340	Fusaric acid resistance protein family; Region: FUSC; pfam04632
891974003341	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
891974003342	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
891974003343	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974003344	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974003345	transcriptional regulator SlyA; Provisional; Region: PRK03573
891974003346	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974003347	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
891974003348	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
891974003349	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
891974003350	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
891974003351	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
891974003352	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
891974003353	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
891974003354	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
891974003355	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
891974003356	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
891974003357	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
891974003358	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
891974003359	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
891974003360	active site
891974003361	HIGH motif; other site
891974003362	dimer interface [polypeptide binding]; other site
891974003363	KMSKS motif; other site
891974003364	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974003365	RNA binding surface [nucleotide binding]; other site
891974003366	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974003367	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
891974003368	ATP binding site [chemical binding]; other site
891974003369	POT family; Region: PTR2; cl17359
891974003370	glutathionine S-transferase; Provisional; Region: PRK10542
891974003371	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
891974003372	C-terminal domain interface [polypeptide binding]; other site
891974003373	GSH binding site (G-site) [chemical binding]; other site
891974003374	dimer interface [polypeptide binding]; other site
891974003375	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
891974003376	dimer interface [polypeptide binding]; other site
891974003377	N-terminal domain interface [polypeptide binding]; other site
891974003378	substrate binding pocket (H-site) [chemical binding]; other site
891974003379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003380	hypothetical protein; Validated; Region: PRK06186
891974003381	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974003382	conserved cys residue [active]
891974003383	electron transport complex RsxE subunit; Provisional; Region: PRK12405
891974003384	endonuclease III; Provisional; Region: PRK10702
891974003385	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
891974003386	minor groove reading motif; other site
891974003387	helix-hairpin-helix signature motif; other site
891974003388	substrate binding pocket [chemical binding]; other site
891974003389	active site
891974003390	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
891974003391	electron transport complex protein RnfG; Validated; Region: PRK01908
891974003392	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
891974003393	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
891974003394	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
891974003395	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
891974003396	SLBB domain; Region: SLBB; pfam10531
891974003397	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
891974003398	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
891974003399	electron transport complex protein RnfB; Provisional; Region: PRK05113
891974003400	Putative Fe-S cluster; Region: FeS; cl17515
891974003401	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
891974003402	electron transport complex protein RsxA; Provisional; Region: PRK05151
891974003403	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
891974003404	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
891974003405	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
891974003406	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974003407	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974003408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974003409	H-loop/switch region; other site
891974003410	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974003411	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974003412	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
891974003413	Mn binding site [ion binding]; other site
891974003414	substrate binding site [chemical binding]; other site
891974003415	L-arabinose isomerase; Region: Arabinose_Isome; pfam02610
891974003416	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974003417	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
891974003418	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
891974003419	ligand binding site [chemical binding]; other site
891974003420	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
891974003421	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974003422	Walker A/P-loop; other site
891974003423	ATP binding site [chemical binding]; other site
891974003424	Q-loop/lid; other site
891974003425	ABC transporter signature motif; other site
891974003426	Walker B; other site
891974003427	D-loop; other site
891974003428	H-loop/switch region; other site
891974003429	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
891974003430	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974003431	TM-ABC transporter signature motif; other site
891974003432	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974003433	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
891974003434	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
891974003435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974003436	putative oxidoreductase; Provisional; Region: PRK11579
891974003437	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974003438	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974003439	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
891974003440	active site
891974003441	purine riboside binding site [chemical binding]; other site
891974003442	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974003443	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974003444	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974003445	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974003446	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
891974003447	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974003448	active site turn [active]
891974003449	phosphorylation site [posttranslational modification]
891974003450	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
891974003451	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
891974003452	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974003453	dimer interface [polypeptide binding]; other site
891974003454	putative CheW interface [polypeptide binding]; other site
891974003455	Anti-sigma-K factor rskA; Region: RskA; pfam10099
891974003456	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
891974003457	Fasciclin domain; Region: Fasciclin; pfam02469
891974003458	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
891974003459	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
891974003460	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
891974003461	fumarate hydratase; Reviewed; Region: fumC; PRK00485
891974003462	Class II fumarases; Region: Fumarase_classII; cd01362
891974003463	active site
891974003464	tetramer interface [polypeptide binding]; other site
891974003465	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
891974003466	Transcriptional regulator; Region: Rrf2; cl17282
891974003467	Rrf2 family protein; Region: rrf2_super; TIGR00738
891974003468	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974003469	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974003470	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
891974003471	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974003472	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
891974003473	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974003474	I-site; other site
891974003475	active site
891974003476	metal binding site [ion binding]; metal-binding site
891974003477	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
891974003478	Flavoprotein; Region: Flavoprotein; cl19190
891974003479	Flavoprotein; Region: Flavoprotein; cl19190
891974003480	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
891974003481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974003482	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
891974003483	dimerization interface [polypeptide binding]; other site
891974003484	substrate binding pocket [chemical binding]; other site
891974003485	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974003486	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974003487	catalytic tetrad [active]
891974003488	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974003489	active site
891974003490	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974003491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974003492	Cupin; Region: Cupin_6; pfam12852
891974003493	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
891974003494	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
891974003495	NADP binding site [chemical binding]; other site
891974003496	putative substrate binding site [chemical binding]; other site
891974003497	active site
891974003498	hypothetical protein; Provisional; Region: PRK06185
891974003499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974003500	Squalene epoxidase; Region: SE; cl17314
891974003501	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
891974003502	Cupin; Region: Cupin_1; smart00835
891974003503	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
891974003504	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
891974003505	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
891974003506	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
891974003507	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
891974003508	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
891974003509	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974003510	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
891974003511	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
891974003512	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
891974003513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974003514	active site
891974003515	phosphorylation site [posttranslational modification]
891974003516	intermolecular recognition site; other site
891974003517	dimerization interface [polypeptide binding]; other site
891974003518	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974003519	DNA binding site [nucleotide binding]
891974003520	MltA-interacting protein MipA; Region: MipA; cl01504
891974003521	MltA-interacting protein MipA; Region: MipA; cl01504
891974003522	short chain dehydrogenase; Region: adh_short; pfam00106
891974003523	classical (c) SDRs; Region: SDR_c; cd05233
891974003524	NAD(P) binding site [chemical binding]; other site
891974003525	active site
891974003526	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974003527	dimerization interface [polypeptide binding]; other site
891974003528	putative DNA binding site [nucleotide binding]; other site
891974003529	putative Zn2+ binding site [ion binding]; other site
891974003530	Uncharacterized conserved protein [Function unknown]; Region: COG2353
891974003531	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
891974003532	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974003533	Cytochrome c; Region: Cytochrom_C; pfam00034
891974003534	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974003535	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974003536	Cytochrome c; Region: Cytochrom_C; pfam00034
891974003537	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974003538	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
891974003539	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974003540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974003541	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
891974003542	catalytic triad [active]
891974003543	conserved cis-peptide bond; other site
891974003544	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
891974003545	TPP-binding site [chemical binding]; other site
891974003546	WYL domain; Region: WYL; pfam13280
891974003547	HTH domain; Region: HTH_11; pfam08279
891974003548	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
891974003549	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974003550	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974003551	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
891974003552	metal binding site [ion binding]; metal-binding site
891974003553	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
891974003554	putative active site [active]
891974003555	metal binding site [ion binding]; metal-binding site
891974003556	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974003557	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974003558	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974003559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974003560	homodimer interface [polypeptide binding]; other site
891974003561	catalytic residue [active]
891974003562	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974003563	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
891974003564	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
891974003565	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
891974003566	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974003567	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
891974003568	ligand-binding site [chemical binding]; other site
891974003569	High-affinity nickel-transport protein; Region: NicO; cl00964
891974003570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974003571	Walker A/P-loop; other site
891974003572	ATP binding site [chemical binding]; other site
891974003573	Q-loop/lid; other site
891974003574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
891974003575	Q-loop/lid; other site
891974003576	ABC transporter signature motif; other site
891974003577	Walker B; other site
891974003578	D-loop; other site
891974003579	H-loop/switch region; other site
891974003580	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
891974003581	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
891974003582	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974003583	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
891974003584	Uncharacterized conserved protein [Function unknown]; Region: COG2128
891974003585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
891974003586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
891974003587	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974003588	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
891974003589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974003590	active site
891974003591	phosphorylation site [posttranslational modification]
891974003592	intermolecular recognition site; other site
891974003593	dimerization interface [polypeptide binding]; other site
891974003594	CheB methylesterase; Region: CheB_methylest; pfam01339
891974003595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003596	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
891974003597	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
891974003598	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
891974003599	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
891974003600	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
891974003601	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
891974003602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003603	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974003604	putative substrate translocation pore; other site
891974003605	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
891974003606	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
891974003607	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974003608	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974003609	Glucuronate isomerase; Region: UxaC; cl00829
891974003610	glucuronate isomerase; Reviewed; Region: PRK02925
891974003611	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
891974003612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974003613	DNA-binding site [nucleotide binding]; DNA binding site
891974003614	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
891974003615	GTP-binding protein YchF; Reviewed; Region: PRK09601
891974003616	YchF GTPase; Region: YchF; cd01900
891974003617	G1 box; other site
891974003618	GTP/Mg2+ binding site [chemical binding]; other site
891974003619	Switch I region; other site
891974003620	G2 box; other site
891974003621	Switch II region; other site
891974003622	G3 box; other site
891974003623	G4 box; other site
891974003624	G5 box; other site
891974003625	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
891974003626	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
891974003627	putative active site [active]
891974003628	catalytic residue [active]
891974003629	hypothetical protein; Provisional; Region: PRK10692
891974003630	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974003631	metal binding site [ion binding]; metal-binding site
891974003632	active site
891974003633	I-site; other site
891974003634	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
891974003635	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
891974003636	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974003637	active site
891974003638	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
891974003639	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
891974003640	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
891974003641	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
891974003642	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
891974003643	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
891974003644	tRNA; other site
891974003645	putative tRNA binding site [nucleotide binding]; other site
891974003646	putative NADP binding site [chemical binding]; other site
891974003647	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
891974003648	peptide chain release factor 1; Validated; Region: prfA; PRK00591
891974003649	This domain is found in peptide chain release factors; Region: PCRF; smart00937
891974003650	RF-1 domain; Region: RF-1; pfam00472
891974003651	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
891974003652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003653	S-adenosylmethionine binding site [chemical binding]; other site
891974003654	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
891974003655	hypothetical protein; Provisional; Region: PRK10941
891974003656	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
891974003657	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
891974003658	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
891974003659	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
891974003660	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
891974003661	putative catalytic residue [active]
891974003662	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
891974003663	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
891974003664	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
891974003665	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
891974003666	AAA domain; Region: AAA_17; cl19128
891974003667	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
891974003668	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
891974003669	hypothetical protein; Provisional; Region: PRK07033
891974003670	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
891974003671	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
891974003672	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
891974003673	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
891974003674	FHIPEP family; Region: FHIPEP; cl07980
891974003675	FHIPEP family; Region: FHIPEP; cl07980
891974003676	Flagellar protein FlhE; Region: FlhE; pfam06366
891974003677	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
891974003678	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
891974003679	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
891974003680	active site
891974003681	HIGH motif; other site
891974003682	KMSK motif region; other site
891974003683	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
891974003684	tRNA binding surface [nucleotide binding]; other site
891974003685	anticodon binding site; other site
891974003686	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
891974003687	putative metal binding site [ion binding]; other site
891974003688	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974003689	catalytic residue [active]
891974003690	homodimer interface [polypeptide binding]; other site
891974003691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974003692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974003693	copper homeostasis protein CutC; Provisional; Region: PRK11572
891974003694	LysE type translocator; Region: LysE; cl00565
891974003695	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
891974003696	tRNA (mo5U34)-methyltransferase; Region: TIGR00452
891974003697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003698	S-adenosylmethionine binding site [chemical binding]; other site
891974003699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003700	S-adenosylmethionine binding site [chemical binding]; other site
891974003701	Protein of unknown function DUF72; Region: DUF72; cl00777
891974003702	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
891974003703	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
891974003704	dimer interface [polypeptide binding]; other site
891974003705	anticodon binding site; other site
891974003706	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
891974003707	homodimer interface [polypeptide binding]; other site
891974003708	motif 1; other site
891974003709	active site
891974003710	motif 2; other site
891974003711	GAD domain; Region: GAD; pfam02938
891974003712	motif 3; other site
891974003713	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
891974003714	nudix motif; other site
891974003715	hypothetical protein; Validated; Region: PRK00110
891974003716	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
891974003717	active site
891974003718	putative DNA-binding cleft [nucleotide binding]; other site
891974003719	dimer interface [polypeptide binding]; other site
891974003720	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
891974003721	RuvA N terminal domain; Region: RuvA_N; pfam01330
891974003722	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
891974003723	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
891974003724	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
891974003725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974003726	Walker A motif; other site
891974003727	ATP binding site [chemical binding]; other site
891974003728	Walker B motif; other site
891974003729	arginine finger; other site
891974003730	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
891974003731	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
891974003732	ABC-ATPase subunit  interface; other site
891974003733	dimer interface [polypeptide binding]; other site
891974003734	putative PBP binding regions; other site
891974003735	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
891974003736	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
891974003737	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
891974003738	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
891974003739	metal binding site [ion binding]; metal-binding site
891974003740	putative peptidase; Provisional; Region: PRK11649
891974003741	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974003742	Peptidase family M23; Region: Peptidase_M23; pfam01551
891974003743	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
891974003744	putative acyl-acceptor binding pocket; other site
891974003745	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718
891974003746	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974003747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003748	pyruvate kinase; Provisional; Region: PRK05826
891974003749	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
891974003750	domain interfaces; other site
891974003751	active site
891974003752	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974003753	putative active site [active]
891974003754	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974003755	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
891974003756	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
891974003757	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
891974003758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974003759	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974003760	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974003761	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974003762	Class I aldolases; Region: Aldolase_Class_I; cl17187
891974003763	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
891974003764	intersubunit interface [polypeptide binding]; other site
891974003765	catalytic residue [active]
891974003766	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
891974003767	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974003768	ATP-grasp domain; Region: ATP-grasp; pfam02222
891974003769	Protein of unknown function (DUF533); Region: DUF533; pfam04391
891974003770	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
891974003771	putative metal binding site [ion binding]; other site
891974003772	protease 2; Provisional; Region: PRK10115
891974003773	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
891974003774	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
891974003775	active site
891974003776	substrate binding site [chemical binding]; other site
891974003777	catalytic site [active]
891974003778	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
891974003779	catalytic site [active]
891974003780	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
891974003781	CopC domain; Region: CopC; cl01012
891974003782	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
891974003783	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
891974003784	DNA-binding site [nucleotide binding]; DNA binding site
891974003785	RNA-binding motif; other site
891974003786	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
891974003787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974003788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003789	S-adenosylmethionine binding site [chemical binding]; other site
891974003790	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
891974003791	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
891974003792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974003793	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835
891974003794	mce related protein; Region: MCE; pfam02470
891974003795	mce related protein; Region: MCE; pfam02470
891974003796	mce related protein; Region: MCE; pfam02470
891974003797	mce related protein; Region: MCE; pfam02470
891974003798	mce related protein; Region: MCE; pfam02470
891974003799	Paraquat-inducible protein A; Region: PqiA; pfam04403
891974003800	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
891974003801	Paraquat-inducible protein A; Region: PqiA; pfam04403
891974003802	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
891974003803	ProP expression regulator; Provisional; Region: PRK04950
891974003804	putative RNA binding sites [nucleotide binding]; other site
891974003805	carboxy-terminal protease; Provisional; Region: PRK11186
891974003806	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
891974003807	protein binding site [polypeptide binding]; other site
891974003808	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
891974003809	Catalytic dyad [active]
891974003810	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
891974003811	heat shock protein HtpX; Provisional; Region: PRK05457
891974003812	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
891974003813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003814	putative substrate translocation pore; other site
891974003815	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
891974003816	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
891974003817	Bacterial transcriptional regulator; Region: IclR; pfam01614
891974003818	YobH-like protein; Region: YobH; pfam13996
891974003819	YebO-like protein; Region: YebO; pfam13974
891974003820	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
891974003821	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
891974003822	DNA-binding site [nucleotide binding]; DNA binding site
891974003823	RNA-binding motif; other site
891974003824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974003825	S-adenosylmethionine binding site [chemical binding]; other site
891974003826	hypothetical protein; Provisional; Region: PRK02913
891974003827	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
891974003828	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
891974003829	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
891974003830	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
891974003831	active pocket/dimerization site; other site
891974003832	active site
891974003833	phosphorylation site [posttranslational modification]
891974003834	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
891974003835	active site
891974003836	phosphorylation site [posttranslational modification]
891974003837	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
891974003838	FOG: CBS domain [General function prediction only]; Region: COG0517
891974003839	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
891974003840	Transporter associated domain; Region: CorC_HlyC; smart01091
891974003841	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974003842	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
891974003843	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
891974003844	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
891974003845	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
891974003846	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
891974003847	putative active site [active]
891974003848	putative CoA binding site [chemical binding]; other site
891974003849	nudix motif; other site
891974003850	metal binding site [ion binding]; metal-binding site
891974003851	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
891974003852	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
891974003853	chorismate binding enzyme; Region: Chorismate_bind; cl10555
891974003854	hypothetical protein; Provisional; Region: PRK05114
891974003855	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
891974003856	homotrimer interaction site [polypeptide binding]; other site
891974003857	putative active site [active]
891974003858	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
891974003859	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974003860	ATP binding site [chemical binding]; other site
891974003861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
891974003862	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974003863	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
891974003864	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
891974003865	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
891974003866	Glycoprotease family; Region: Peptidase_M22; pfam00814
891974003867	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
891974003868	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974003869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974003870	acyl-activating enzyme (AAE) consensus motif; other site
891974003871	CoA binding site [chemical binding]; other site
891974003872	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974003873	AMP binding site [chemical binding]; other site
891974003874	active site
891974003875	CoA binding site [chemical binding]; other site
891974003876	ribonuclease D; Provisional; Region: PRK10829
891974003877	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
891974003878	catalytic site [active]
891974003879	putative active site [active]
891974003880	putative substrate binding site [chemical binding]; other site
891974003881	HRDC domain; Region: HRDC; pfam00570
891974003882	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
891974003883	cell division inhibitor MinD; Provisional; Region: PRK10818
891974003884	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
891974003885	P-loop; other site
891974003886	ADP binding residues [chemical binding]; other site
891974003887	Switch I; other site
891974003888	Switch II; other site
891974003889	septum formation inhibitor; Reviewed; Region: minC; PRK03511
891974003890	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
891974003891	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
891974003892	YcgL domain; Region: YcgL; cl01189
891974003893	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
891974003894	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
891974003895	hypothetical protein; Provisional; Region: PRK05170
891974003896	disulfide bond formation protein B; Provisional; Region: PRK01749
891974003897	fatty acid metabolism regulator; Provisional; Region: PRK04984
891974003898	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974003899	DNA-binding site [nucleotide binding]; DNA binding site
891974003900	FadR C-terminal domain; Region: FadR_C; pfam07840
891974003901	SpoVR family protein; Provisional; Region: PRK11767
891974003902	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
891974003903	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
891974003904	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974003905	alanine racemase; Reviewed; Region: dadX; PRK03646
891974003906	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
891974003907	active site
891974003908	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
891974003909	substrate binding site [chemical binding]; other site
891974003910	catalytic residues [active]
891974003911	dimer interface [polypeptide binding]; other site
891974003912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974003913	putative substrate translocation pore; other site
891974003914	CoA binding domain; Region: CoA_binding; cl17356
891974003915	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
891974003916	Bacterial sugar transferase; Region: Bac_transf; pfam02397
891974003917	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
891974003918	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
891974003919	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
891974003920	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
891974003921	TrkA-C domain; Region: TrkA_C; pfam02080
891974003922	Transporter associated domain; Region: CorC_HlyC; smart01091
891974003923	hypothetical protein; Provisional; Region: PRK05325
891974003924	PrkA family serine protein kinase; Provisional; Region: PRK15455
891974003925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974003926	Walker A motif; other site
891974003927	ATP binding site [chemical binding]; other site
891974003928	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
891974003929	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
891974003930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974003931	active site
891974003932	catalytic tetrad [active]
891974003933	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
891974003934	catalytic residues [active]
891974003935	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
891974003936	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
891974003937	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
891974003938	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
891974003939	methionine sulfoxide reductase B; Provisional; Region: PRK00222
891974003940	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
891974003941	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
891974003942	catalytic triad [active]
891974003943	conserved cis-peptide bond; other site
891974003944	cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461
891974003945	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
891974003946	active site
891974003947	homodimer interface [polypeptide binding]; other site
891974003948	protease 4; Provisional; Region: PRK10949
891974003949	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
891974003950	tandem repeat interface [polypeptide binding]; other site
891974003951	oligomer interface [polypeptide binding]; other site
891974003952	active site residues [active]
891974003953	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
891974003954	tandem repeat interface [polypeptide binding]; other site
891974003955	oligomer interface [polypeptide binding]; other site
891974003956	active site residues [active]
891974003957	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
891974003958	putative FMN binding site [chemical binding]; other site
891974003959	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
891974003960	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
891974003961	ATP binding site [chemical binding]; other site
891974003962	dimerization interface [polypeptide binding]; other site
891974003963	DNA topoisomerase III; Provisional; Region: PRK07726
891974003964	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
891974003965	active site
891974003966	putative interdomain interaction site [polypeptide binding]; other site
891974003967	putative metal-binding site [ion binding]; other site
891974003968	putative nucleotide binding site [chemical binding]; other site
891974003969	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
891974003970	domain I; other site
891974003971	DNA binding groove [nucleotide binding]
891974003972	phosphate binding site [ion binding]; other site
891974003973	domain II; other site
891974003974	domain III; other site
891974003975	nucleotide binding site [chemical binding]; other site
891974003976	catalytic site [active]
891974003977	domain IV; other site
891974003978	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
891974003979	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
891974003980	putative catalytic site [active]
891974003981	putative phosphate binding site [ion binding]; other site
891974003982	active site
891974003983	metal binding site A [ion binding]; metal-binding site
891974003984	DNA binding site [nucleotide binding]
891974003985	putative AP binding site [nucleotide binding]; other site
891974003986	putative metal binding site B [ion binding]; other site
891974003987	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
891974003988	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
891974003989	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
891974003990	putative active site [active]
891974003991	putative substrate binding site [chemical binding]; other site
891974003992	putative cosubstrate binding site; other site
891974003993	catalytic site [active]
891974003994	SEC-C motif; Region: SEC-C; cl19389
891974003995	SEC-C motif; Region: SEC-C; cl19389
891974003996	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
891974003997	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
891974003998	active site
891974003999	nucleophile elbow; other site
891974004000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004001	active site
891974004002	response regulator of RpoS; Provisional; Region: PRK10693
891974004003	phosphorylation site [posttranslational modification]
891974004004	intermolecular recognition site; other site
891974004005	dimerization interface [polypeptide binding]; other site
891974004006	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
891974004007	active site
891974004008	tetramer interface; other site
891974004009	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
891974004010	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
891974004011	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
891974004012	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
891974004013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
891974004014	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
891974004015	putative NAD(P) binding site [chemical binding]; other site
891974004016	active site
891974004017	putative substrate binding site [chemical binding]; other site
891974004018	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
891974004019	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
891974004020	thymidine kinase; Provisional; Region: PRK04296
891974004021	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974004022	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
891974004023	active site
891974004024	NAD binding site [chemical binding]; other site
891974004025	metal binding site [ion binding]; metal-binding site
891974004026	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974004027	MarC family integral membrane protein; Region: MarC; cl00919
891974004028	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974004029	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004030	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974004031	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004032	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004033	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004034	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974004035	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974004036	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
891974004037	peptide binding site [polypeptide binding]; other site
891974004038	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
891974004039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974004040	dimer interface [polypeptide binding]; other site
891974004041	conserved gate region; other site
891974004042	putative PBP binding loops; other site
891974004043	ABC-ATPase subunit interface; other site
891974004044	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974004045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974004046	dimer interface [polypeptide binding]; other site
891974004047	ABC-ATPase subunit interface; other site
891974004048	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
891974004049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004050	Walker A/P-loop; other site
891974004051	ATP binding site [chemical binding]; other site
891974004052	Q-loop/lid; other site
891974004053	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974004054	ABC transporter signature motif; other site
891974004055	Walker B; other site
891974004056	D-loop; other site
891974004057	H-loop/switch region; other site
891974004058	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974004059	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
891974004060	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974004061	Walker A/P-loop; other site
891974004062	ATP binding site [chemical binding]; other site
891974004063	Q-loop/lid; other site
891974004064	ABC transporter signature motif; other site
891974004065	Walker B; other site
891974004066	D-loop; other site
891974004067	H-loop/switch region; other site
891974004068	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974004069	dsDNA-mimic protein; Reviewed; Region: PRK05094
891974004070	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
891974004071	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
891974004072	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
891974004073	putative active site [active]
891974004074	catalytic site [active]
891974004075	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
891974004076	putative active site [active]
891974004077	catalytic site [active]
891974004078	YciI-like protein; Reviewed; Region: PRK11370
891974004079	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
891974004080	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
891974004081	intracellular septation protein A; Reviewed; Region: PRK00259
891974004082	hypothetical protein; Provisional; Region: PRK02868
891974004083	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
891974004084	OmpW family; Region: OmpW; cl17427
891974004085	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
891974004086	substrate binding site [chemical binding]; other site
891974004087	active site
891974004088	catalytic residues [active]
891974004089	heterodimer interface [polypeptide binding]; other site
891974004090	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974004091	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974004092	catalytic residue [active]
891974004093	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
891974004094	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
891974004095	active site
891974004096	ribulose/triose binding site [chemical binding]; other site
891974004097	phosphate binding site [ion binding]; other site
891974004098	substrate (anthranilate) binding pocket [chemical binding]; other site
891974004099	product (indole) binding pocket [chemical binding]; other site
891974004100	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
891974004101	active site
891974004102	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
891974004103	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
891974004104	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
891974004105	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
891974004106	Glutamine amidotransferase class-I; Region: GATase; pfam00117
891974004107	glutamine binding [chemical binding]; other site
891974004108	catalytic triad [active]
891974004109	anthranilate synthase component I; Provisional; Region: PRK13564
891974004110	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
891974004111	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
891974004112	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
891974004113	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974004114	RNA binding surface [nucleotide binding]; other site
891974004115	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
891974004116	probable active site [active]
891974004117	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
891974004118	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
891974004119	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
891974004120	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
891974004121	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
891974004122	NAD(P) binding site [chemical binding]; other site
891974004123	active site
891974004124	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
891974004125	putative inner membrane peptidase; Provisional; Region: PRK11778
891974004126	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
891974004127	tandem repeat interface [polypeptide binding]; other site
891974004128	oligomer interface [polypeptide binding]; other site
891974004129	active site residues [active]
891974004130	Protein of unknown function (DUF2498); Region: DUF2498; cl11671
891974004131	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
891974004132	active site
891974004133	interdomain interaction site; other site
891974004134	putative metal-binding site [ion binding]; other site
891974004135	nucleotide binding site [chemical binding]; other site
891974004136	DNA topoisomerase; Region: Topoisom_bac; pfam01131
891974004137	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
891974004138	domain I; other site
891974004139	DNA binding groove [nucleotide binding]
891974004140	phosphate binding site [ion binding]; other site
891974004141	domain II; other site
891974004142	domain III; other site
891974004143	nucleotide binding site [chemical binding]; other site
891974004144	catalytic site [active]
891974004145	domain IV; other site
891974004146	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
891974004147	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
891974004148	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
891974004149	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
891974004150	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
891974004151	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
891974004152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004153	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
891974004154	substrate binding site [chemical binding]; other site
891974004155	putative dimerization interface [polypeptide binding]; other site
891974004156	aconitate hydratase; Validated; Region: PRK09277
891974004157	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
891974004158	substrate binding site [chemical binding]; other site
891974004159	ligand binding site [chemical binding]; other site
891974004160	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
891974004161	substrate binding site [chemical binding]; other site
891974004162	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
891974004163	dimerization interface [polypeptide binding]; other site
891974004164	active site
891974004165	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
891974004166	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
891974004167	active site
891974004168	Predicted membrane protein [Function unknown]; Region: COG3771
891974004169	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
891974004170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
891974004171	TPR motif; other site
891974004172	binding surface
891974004173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
891974004174	binding surface
891974004175	TPR motif; other site
891974004176	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
891974004177	active site
891974004178	dimer interface [polypeptide binding]; other site
891974004179	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
891974004180	putative rRNA binding site [nucleotide binding]; other site
891974004181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974004182	metal binding site [ion binding]; metal-binding site
891974004183	active site
891974004184	I-site; other site
891974004185	Carbon starvation protein CstA; Region: CstA; pfam02554
891974004186	exoribonuclease II; Provisional; Region: PRK05054
891974004187	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
891974004188	RNB domain; Region: RNB; pfam00773
891974004189	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
891974004190	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
891974004191	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
891974004192	putative molybdopterin cofactor binding site [chemical binding]; other site
891974004193	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
891974004194	putative molybdopterin cofactor binding site; other site
891974004195	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974004196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974004197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
891974004199	dimerization interface [polypeptide binding]; other site
891974004200	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
891974004201	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
891974004202	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
891974004203	NAD binding site [chemical binding]; other site
891974004204	homotetramer interface [polypeptide binding]; other site
891974004205	homodimer interface [polypeptide binding]; other site
891974004206	substrate binding site [chemical binding]; other site
891974004207	active site
891974004208	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004209	ABC transporter signature motif; other site
891974004210	Walker B; other site
891974004211	D-loop; other site
891974004212	H-loop/switch region; other site
891974004213	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974004214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004215	Walker A/P-loop; other site
891974004216	ATP binding site [chemical binding]; other site
891974004217	Q-loop/lid; other site
891974004218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004219	Walker B; other site
891974004220	D-loop; other site
891974004221	H-loop/switch region; other site
891974004222	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974004223	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
891974004224	active site
891974004225	dimer interface [polypeptide binding]; other site
891974004226	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
891974004227	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974004228	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974004229	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974004230	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974004231	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974004232	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
891974004233	YjbR; Region: YjbR; cl15265
891974004234	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
891974004235	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974004236	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974004237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004238	malonic semialdehyde reductase; Provisional; Region: PRK10538
891974004239	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
891974004240	putative NAD(P) binding site [chemical binding]; other site
891974004241	homotetramer interface [polypeptide binding]; other site
891974004242	homodimer interface [polypeptide binding]; other site
891974004243	active site
891974004244	hypothetical protein; Provisional; Region: PRK02237
891974004245	hypothetical protein; Provisional; Region: PRK13659
891974004246	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
891974004247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974004248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974004249	putative substrate translocation pore; other site
891974004250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974004251	dimer interface [polypeptide binding]; other site
891974004252	conserved gate region; other site
891974004253	putative PBP binding loops; other site
891974004254	ABC-ATPase subunit interface; other site
891974004255	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004256	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
891974004257	Walker A/P-loop; other site
891974004258	ATP binding site [chemical binding]; other site
891974004259	Q-loop/lid; other site
891974004260	ABC transporter signature motif; other site
891974004261	Walker B; other site
891974004262	D-loop; other site
891974004263	H-loop/switch region; other site
891974004264	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
891974004265	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974004266	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974004267	AAA domain; Region: AAA_26; pfam13500
891974004268	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
891974004269	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974004270	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974004271	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
891974004272	substrate binding pocket [chemical binding]; other site
891974004273	dimerization interface [polypeptide binding]; other site
891974004274	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004275	methionine aminotransferase; Validated; Region: PRK09082
891974004276	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974004277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974004278	homodimer interface [polypeptide binding]; other site
891974004279	catalytic residue [active]
891974004280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974004282	dimerization interface [polypeptide binding]; other site
891974004283	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
891974004284	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
891974004285	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974004286	dimerization interface [polypeptide binding]; other site
891974004287	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974004288	dimer interface [polypeptide binding]; other site
891974004289	putative CheW interface [polypeptide binding]; other site
891974004290	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
891974004291	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
891974004292	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
891974004293	substrate binding pocket [chemical binding]; other site
891974004294	DoxX; Region: DoxX; pfam07681
891974004295	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
891974004296	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
891974004297	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
891974004298	benzoate transport; Region: 2A0115; TIGR00895
891974004299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974004300	putative substrate translocation pore; other site
891974004301	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
891974004302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004303	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974004304	dimerization interface [polypeptide binding]; other site
891974004305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
891974004306	Smr domain; Region: Smr; pfam01713
891974004307	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
891974004308	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
891974004309	putative switch regulator; other site
891974004310	non-specific DNA interactions [nucleotide binding]; other site
891974004311	DNA binding site [nucleotide binding]
891974004312	sequence specific DNA binding site [nucleotide binding]; other site
891974004313	putative cAMP binding site [chemical binding]; other site
891974004314	universal stress protein UspE; Provisional; Region: PRK11175
891974004315	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974004316	Ligand Binding Site [chemical binding]; other site
891974004317	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974004318	Ligand Binding Site [chemical binding]; other site
891974004319	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
891974004320	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
891974004321	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
891974004322	ligand binding site [chemical binding]; other site
891974004323	homodimer interface [polypeptide binding]; other site
891974004324	NAD(P) binding site [chemical binding]; other site
891974004325	trimer interface B [polypeptide binding]; other site
891974004326	trimer interface A [polypeptide binding]; other site
891974004327	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
891974004328	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974004329	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974004330	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974004331	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
891974004332	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
891974004333	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
891974004334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004335	active site
891974004336	phosphorylation site [posttranslational modification]
891974004337	intermolecular recognition site; other site
891974004338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974004339	DNA binding site [nucleotide binding]
891974004340	sensor protein RstB; Provisional; Region: PRK10604
891974004341	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974004342	dimerization interface [polypeptide binding]; other site
891974004343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974004344	dimer interface [polypeptide binding]; other site
891974004345	phosphorylation site [posttranslational modification]
891974004346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974004347	ATP binding site [chemical binding]; other site
891974004348	Mg2+ binding site [ion binding]; other site
891974004349	G-X-G motif; other site
891974004350	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
891974004351	active site
891974004352	Zn binding site [ion binding]; other site
891974004353	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
891974004354	Trypsin; Region: Trypsin; pfam00089
891974004355	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
891974004356	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
891974004357	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
891974004358	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
891974004359	Helicase associated domain (HA2); Region: HA2; pfam04408
891974004360	DEAD-like helicases superfamily; Region: DEXDc; smart00487
891974004361	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974004362	ATP binding site [chemical binding]; other site
891974004363	putative Mg++ binding site [ion binding]; other site
891974004364	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974004365	nucleotide binding region [chemical binding]; other site
891974004366	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974004367	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974004368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
891974004369	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
891974004370	hypothetical protein; Provisional; Region: PRK10695
891974004371	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
891974004372	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
891974004373	putative ligand binding site [chemical binding]; other site
891974004374	putative NAD binding site [chemical binding]; other site
891974004375	catalytic site [active]
891974004376	Domain of unknown function (DUF333); Region: DUF333; cl19829
891974004377	MgtC family; Region: MgtC; pfam02308
891974004378	Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681
891974004379	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
891974004380	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
891974004381	Ligand Binding Site [chemical binding]; other site
891974004382	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
891974004383	oligomer interface [polypeptide binding]; other site
891974004384	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
891974004385	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
891974004386	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974004387	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974004388	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
891974004389	murein peptide amidase A; Provisional; Region: PRK10602
891974004390	active site
891974004391	Zn binding site [ion binding]; other site
891974004392	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
891974004393	active site
891974004394	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974004395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974004396	Walker A motif; other site
891974004397	ATP binding site [chemical binding]; other site
891974004398	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
891974004399	HipA-like N-terminal domain; Region: HipA_N; pfam07805
891974004400	HipA-like C-terminal domain; Region: HipA_C; pfam07804
891974004401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974004402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974004403	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
891974004404	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
891974004405	Outer membrane efflux protein; Region: OEP; pfam02321
891974004406	Outer membrane efflux protein; Region: OEP; pfam02321
891974004407	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974004408	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
891974004409	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974004410	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
891974004411	putative active site [active]
891974004412	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
891974004413	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974004414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004415	Walker A/P-loop; other site
891974004416	ATP binding site [chemical binding]; other site
891974004417	Q-loop/lid; other site
891974004418	ABC transporter signature motif; other site
891974004419	Walker B; other site
891974004420	D-loop; other site
891974004421	H-loop/switch region; other site
891974004422	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
891974004423	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
891974004424	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
891974004425	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974004426	metal binding site [ion binding]; metal-binding site
891974004427	active site
891974004428	I-site; other site
891974004429	putative diguanylate cyclase; Provisional; Region: PRK09776
891974004430	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
891974004431	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974004432	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
891974004433	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
891974004434	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974004435	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
891974004436	active site clefts [active]
891974004437	zinc binding site [ion binding]; other site
891974004438	dimer interface [polypeptide binding]; other site
891974004439	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
891974004440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974004441	active site
891974004442	motif I; other site
891974004443	motif II; other site
891974004444	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
891974004445	fructuronate transporter; Provisional; Region: PRK10034; cl15264
891974004446	GntP family permease; Region: GntP_permease; pfam02447
891974004447	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
891974004448	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
891974004449	NADP binding site [chemical binding]; other site
891974004450	homodimer interface [polypeptide binding]; other site
891974004451	active site
891974004452	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
891974004453	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
891974004454	putative NAD(P) binding site [chemical binding]; other site
891974004455	catalytic Zn binding site [ion binding]; other site
891974004456	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
891974004457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004458	active site
891974004459	phosphorylation site [posttranslational modification]
891974004460	intermolecular recognition site; other site
891974004461	dimerization interface [polypeptide binding]; other site
891974004462	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974004463	DNA binding residues [nucleotide binding]
891974004464	dimerization interface [polypeptide binding]; other site
891974004465	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
891974004466	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
891974004467	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974004468	putative active site [active]
891974004469	heme pocket [chemical binding]; other site
891974004470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974004471	ATP binding site [chemical binding]; other site
891974004472	Mg2+ binding site [ion binding]; other site
891974004473	G-X-G motif; other site
891974004474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004475	active site
891974004476	phosphorylation site [posttranslational modification]
891974004477	intermolecular recognition site; other site
891974004478	dimerization interface [polypeptide binding]; other site
891974004479	Hpt domain; Region: Hpt; pfam01627
891974004480	putative binding surface; other site
891974004481	active site
891974004482	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
891974004483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004484	active site
891974004485	intermolecular recognition site; other site
891974004486	dimerization interface [polypeptide binding]; other site
891974004487	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974004488	DNA binding residues [nucleotide binding]
891974004489	dimerization interface [polypeptide binding]; other site
891974004490	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974004491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974004492	S-adenosylmethionine binding site [chemical binding]; other site
891974004493	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
891974004494	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
891974004495	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
891974004496	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
891974004497	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
891974004498	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974004499	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974004500	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
891974004501	serine/threonine transporter SstT; Provisional; Region: PRK13628
891974004502	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
891974004503	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
891974004504	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
891974004505	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974004506	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
891974004507	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
891974004508	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
891974004509	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
891974004510	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
891974004511	Predicted membrane protein [Function unknown]; Region: COG5393
891974004512	YqjK-like protein; Region: YqjK; pfam13997
891974004513	Predicted membrane protein [Function unknown]; Region: COG2259
891974004514	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
891974004515	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
891974004516	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974004517	N-terminal domain interface [polypeptide binding]; other site
891974004518	dimer interface [polypeptide binding]; other site
891974004519	substrate binding pocket (H-site) [chemical binding]; other site
891974004520	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974004521	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
891974004522	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
891974004523	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
891974004524	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
891974004525	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
891974004526	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
891974004527	putative ligand binding site [chemical binding]; other site
891974004528	hypothetical protein; Reviewed; Region: PRK12497
891974004529	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
891974004530	dimer interface [polypeptide binding]; other site
891974004531	active site
891974004532	outer membrane lipoprotein; Provisional; Region: PRK11023
891974004533	BON domain; Region: BON; pfam04972
891974004534	BON domain; Region: BON; pfam04972
891974004535	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057
891974004536	Pirin; Region: Pirin; pfam02678
891974004537	Pirin-related protein [General function prediction only]; Region: COG1741
891974004538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974004539	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974004540	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974004541	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974004542	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
891974004543	PRD domain; Region: PRD; pfam00874
891974004544	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
891974004545	active site
891974004546	P-loop; other site
891974004547	phosphorylation site [posttranslational modification]
891974004548	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
891974004549	active site
891974004550	phosphorylation site [posttranslational modification]
891974004551	HTH domain; Region: HTH_11; pfam08279
891974004552	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
891974004553	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974004554	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974004555	catalytic residue [active]
891974004556	dihydroorotase; Provisional; Region: PRK09237
891974004557	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974004558	active site
891974004559	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
891974004560	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
891974004561	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
891974004562	Domain of unknown function (DUF4312); Region: DUF4312; cl11917
891974004563	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974004564	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974004565	catalytic residues [active]
891974004566	catalytic nucleophile [active]
891974004567	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974004568	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974004569	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974004570	Synaptic Site I dimer interface [polypeptide binding]; other site
891974004571	DNA binding site [nucleotide binding]
891974004572	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974004573	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974004574	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974004575	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974004576	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974004577	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
891974004578	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
891974004579	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974004580	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974004581	Phage Tail Protein X; Region: Phage_tail_X; cl02088
891974004582	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
891974004583	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
891974004584	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
891974004585	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
891974004586	Phage tail tube protein FII; Region: Phage_tube; cl01390
891974004587	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
891974004588	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
891974004589	Gp37 protein; Region: Gp37; pfam09646
891974004590	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
891974004591	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
891974004592	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
891974004593	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
891974004594	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974004595	Protein of unknown function (DUF935); Region: DUF935; pfam06074
891974004596	Phage Terminase; Region: Terminase_1; cl19862
891974004597	Terminase-like family; Region: Terminase_6; pfam03237
891974004598	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974004599	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974004600	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974004601	Transcriptional regulator; Region: Rrf2; cl17282
891974004602	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974004603	Integrase core domain; Region: rve; pfam00665
891974004604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974004605	non-specific DNA binding site [nucleotide binding]; other site
891974004606	salt bridge; other site
891974004607	sequence-specific DNA binding site [nucleotide binding]; other site
891974004608	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974004609	AAA domain; Region: AAA_22; pfam13401
891974004610	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974004611	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974004612	Mor transcription activator family; Region: Mor; pfam08765
891974004613	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916
891974004614	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
891974004615	Cytochrome b562; Region: Cytochrom_B562; cl01546
891974004616	peptidase PmbA; Provisional; Region: PRK11040
891974004617	hypothetical protein; Provisional; Region: PRK05255
891974004618	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
891974004619	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
891974004620	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974004621	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974004622	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
891974004623	AMP binding site [chemical binding]; other site
891974004624	metal binding site [ion binding]; metal-binding site
891974004625	active site
891974004626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974004627	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974004628	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974004629	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
891974004630	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
891974004631	GAF domain; Region: GAF; pfam01590
891974004632	Histidine kinase; Region: His_kinase; pfam06580
891974004633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974004634	ATP binding site [chemical binding]; other site
891974004635	G-X-G motif; other site
891974004636	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
891974004637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004638	active site
891974004639	phosphorylation site [posttranslational modification]
891974004640	intermolecular recognition site; other site
891974004641	dimerization interface [polypeptide binding]; other site
891974004642	LytTr DNA-binding domain; Region: LytTR; pfam04397
891974004643	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974004644	glucokinase; Provisional; Region: glk; PRK00292
891974004645	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974004646	nucleotide binding site [chemical binding]; other site
891974004647	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
891974004648	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
891974004649	PYR/PP interface [polypeptide binding]; other site
891974004650	dimer interface [polypeptide binding]; other site
891974004651	TPP binding site [chemical binding]; other site
891974004652	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974004653	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
891974004654	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
891974004655	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974004656	active site
891974004657	catalytic tetrad [active]
891974004658	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
891974004659	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
891974004660	manganese transport protein MntH; Reviewed; Region: PRK00701
891974004661	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
891974004662	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
891974004663	Nucleoside recognition; Region: Gate; pfam07670
891974004664	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
891974004665	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
891974004666	dimer interface [polypeptide binding]; other site
891974004667	active site
891974004668	non-prolyl cis peptide bond; other site
891974004669	insertion regions; other site
891974004670	NMT1-like family; Region: NMT1_2; cl17432
891974004671	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
891974004672	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
891974004673	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
891974004674	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
891974004675	active site
891974004676	HIGH motif; other site
891974004677	KMSKS motif; other site
891974004678	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
891974004679	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974004680	Transposase; Region: HTH_Tnp_1; cl17663
891974004681	Integrase core domain; Region: rve; pfam00665
891974004682	Integrase core domain; Region: rve_3; pfam13683
891974004683	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
891974004684	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074
891974004685	multifunctional aminopeptidase A; Provisional; Region: PRK00913
891974004686	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
891974004687	interface (dimer of trimers) [polypeptide binding]; other site
891974004688	Substrate-binding/catalytic site; other site
891974004689	Zn-binding sites [ion binding]; other site
891974004690	DNA polymerase III subunit chi; Validated; Region: PRK05728
891974004691	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
891974004692	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
891974004693	active site
891974004694	HIGH motif; other site
891974004695	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
891974004696	KMSKS motif; other site
891974004697	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
891974004698	tRNA binding surface [nucleotide binding]; other site
891974004699	anticodon binding site; other site
891974004700	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
891974004701	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974004702	Coenzyme A binding pocket [chemical binding]; other site
891974004703	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
891974004704	dinuclear metal binding motif [ion binding]; other site
891974004705	RNase E inhibitor protein; Provisional; Region: PRK11191
891974004706	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
891974004707	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
891974004708	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
891974004709	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
891974004710	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
891974004711	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
891974004712	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
891974004713	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
891974004714	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
891974004715	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974004716	homotrimer interaction site [polypeptide binding]; other site
891974004717	putative active site [active]
891974004718	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
891974004719	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
891974004720	active site
891974004721	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741
891974004722	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
891974004723	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741
891974004724	ATP cone domain; Region: ATP-cone; pfam03477
891974004725	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
891974004726	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
891974004727	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
891974004728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974004729	FeS/SAM binding site; other site
891974004730	Predicted permease; Region: DUF318; cl17795
891974004731	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
891974004732	intracellular protease, PfpI family; Region: PfpI; TIGR01382
891974004733	proposed catalytic triad [active]
891974004734	conserved cys residue [active]
891974004735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897
891974004736	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
891974004737	GIY-YIG motif/motif A; other site
891974004738	putative active site [active]
891974004739	putative metal binding site [ion binding]; other site
891974004740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974004741	Coenzyme A binding pocket [chemical binding]; other site
891974004742	SCP-2 sterol transfer family; Region: SCP2; cl01225
891974004743	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
891974004744	Peptidase family U32; Region: Peptidase_U32; cl03113
891974004745	Peptidase family U32; Region: Peptidase_U32; cl03113
891974004746	Peptidase family U32; Region: Peptidase_U32; cl03113
891974004747	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974004748	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
891974004749	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974004750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974004751	NAD(P) binding site [chemical binding]; other site
891974004752	active site
891974004753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974004754	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
891974004755	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
891974004756	ATP binding site [chemical binding]; other site
891974004757	Mg++ binding site [ion binding]; other site
891974004758	motif III; other site
891974004759	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974004760	nucleotide binding region [chemical binding]; other site
891974004761	ATP-binding site [chemical binding]; other site
891974004762	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
891974004763	putative RNA binding site [nucleotide binding]; other site
891974004764	Cold shock protein DEAD box A; Region: DEADboxA; pfam12343
891974004765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
891974004766	TPR repeat; Region: TPR_11; pfam13414
891974004767	binding surface
891974004768	TPR motif; other site
891974004769	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
891974004770	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
891974004771	RNase E interface [polypeptide binding]; other site
891974004772	trimer interface [polypeptide binding]; other site
891974004773	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
891974004774	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
891974004775	RNase E interface [polypeptide binding]; other site
891974004776	trimer interface [polypeptide binding]; other site
891974004777	active site
891974004778	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
891974004779	putative nucleic acid binding region [nucleotide binding]; other site
891974004780	G-X-X-G motif; other site
891974004781	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
891974004782	RNA binding site [nucleotide binding]; other site
891974004783	domain interface; other site
891974004784	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
891974004785	16S/18S rRNA binding site [nucleotide binding]; other site
891974004786	S13e-L30e interaction site [polypeptide binding]; other site
891974004787	25S rRNA binding site [nucleotide binding]; other site
891974004788	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
891974004789	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
891974004790	RNA binding site [nucleotide binding]; other site
891974004791	active site
891974004792	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
891974004793	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
891974004794	translation initiation factor IF-2; Region: IF-2; TIGR00487
891974004795	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
891974004796	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
891974004797	G1 box; other site
891974004798	putative GEF interaction site [polypeptide binding]; other site
891974004799	GTP/Mg2+ binding site [chemical binding]; other site
891974004800	Switch I region; other site
891974004801	G2 box; other site
891974004802	G3 box; other site
891974004803	Switch II region; other site
891974004804	G4 box; other site
891974004805	G5 box; other site
891974004806	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
891974004807	Translation-initiation factor 2; Region: IF-2; pfam11987
891974004808	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
891974004809	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
891974004810	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
891974004811	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
891974004812	NusA N-terminal domain; Region: NusA_N; pfam08529
891974004813	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
891974004814	RNA binding site [nucleotide binding]; other site
891974004815	homodimer interface [polypeptide binding]; other site
891974004816	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
891974004817	G-X-X-G motif; other site
891974004818	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
891974004819	G-X-X-G motif; other site
891974004820	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
891974004821	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
891974004822	hypothetical protein; Provisional; Region: PRK14641
891974004823	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
891974004824	putative oligomer interface [polypeptide binding]; other site
891974004825	putative RNA binding site [nucleotide binding]; other site
891974004826	Preprotein translocase SecG subunit; Region: SecG; pfam03840
891974004827	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
891974004828	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
891974004829	active site
891974004830	substrate binding site [chemical binding]; other site
891974004831	metal binding site [ion binding]; metal-binding site
891974004832	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
891974004833	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
891974004834	substrate binding pocket [chemical binding]; other site
891974004835	dimer interface [polypeptide binding]; other site
891974004836	inhibitor binding site; inhibition site
891974004837	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
891974004838	FtsH Extracellular; Region: FtsH_ext; pfam06480
891974004839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974004840	Walker A motif; other site
891974004841	ATP binding site [chemical binding]; other site
891974004842	Walker B motif; other site
891974004843	arginine finger; other site
891974004844	Peptidase family M41; Region: Peptidase_M41; pfam01434
891974004845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974004846	S-adenosylmethionine binding site [chemical binding]; other site
891974004847	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
891974004848	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
891974004849	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
891974004850	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
891974004851	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
891974004852	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
891974004853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004854	active site
891974004855	phosphorylation site [posttranslational modification]
891974004856	intermolecular recognition site; other site
891974004857	dimerization interface [polypeptide binding]; other site
891974004858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
891974004859	DNA binding site [nucleotide binding]
891974004860	sensor protein BasS/PmrB; Provisional; Region: PRK10755
891974004861	HAMP domain; Region: HAMP; pfam00672
891974004862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974004863	dimer interface [polypeptide binding]; other site
891974004864	phosphorylation site [posttranslational modification]
891974004865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974004866	ATP binding site [chemical binding]; other site
891974004867	Mg2+ binding site [ion binding]; other site
891974004868	G-X-G motif; other site
891974004869	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974004870	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974004871	outer membrane receptor FepA; Provisional; Region: PRK13524
891974004872	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974004873	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
891974004874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974004875	putative substrate translocation pore; other site
891974004876	enterobactin exporter EntS; Provisional; Region: PRK10489
891974004877	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
891974004878	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
891974004879	siderophore binding site; other site
891974004880	isochorismate synthase EntC; Provisional; Region: PRK15016
891974004881	chorismate binding enzyme; Region: Chorismate_bind; cl10555
891974004882	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974004883	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974004884	acyl-activating enzyme (AAE) consensus motif; other site
891974004885	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974004886	active site
891974004887	AMP binding site [chemical binding]; other site
891974004888	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974004889	CoA binding site [chemical binding]; other site
891974004890	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
891974004891	catalytic triad [active]
891974004892	conserved cis-peptide bond; other site
891974004893	Phosphopantetheine attachment site; Region: PP-binding; cl09936
891974004894	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
891974004895	CoenzymeA binding site [chemical binding]; other site
891974004896	subunit interaction site [polypeptide binding]; other site
891974004897	PHB binding site; other site
891974004898	GTPase CgtA; Reviewed; Region: obgE; PRK12298
891974004899	GTP1/OBG; Region: GTP1_OBG; pfam01018
891974004900	Obg GTPase; Region: Obg; cd01898
891974004901	G1 box; other site
891974004902	GTP/Mg2+ binding site [chemical binding]; other site
891974004903	Switch I region; other site
891974004904	G2 box; other site
891974004905	G3 box; other site
891974004906	Switch II region; other site
891974004907	G4 box; other site
891974004908	G5 box; other site
891974004909	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
891974004910	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
891974004911	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
891974004912	substrate binding pocket [chemical binding]; other site
891974004913	chain length determination region; other site
891974004914	substrate-Mg2+ binding site; other site
891974004915	catalytic residues [active]
891974004916	aspartate-rich region 1; other site
891974004917	active site lid residues [active]
891974004918	aspartate-rich region 2; other site
891974004919	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
891974004920	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
891974004921	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
891974004922	hinge; other site
891974004923	active site
891974004924	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
891974004925	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
891974004926	anti sigma factor interaction site; other site
891974004927	regulatory phosphorylation site [posttranslational modification]; other site
891974004928	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
891974004929	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
891974004930	mce related protein; Region: MCE; pfam02470
891974004931	conserved hypothetical integral membrane protein; Region: TIGR00056
891974004932	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
891974004933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974004934	Walker A/P-loop; other site
891974004935	ATP binding site [chemical binding]; other site
891974004936	Q-loop/lid; other site
891974004937	ABC transporter signature motif; other site
891974004938	Walker B; other site
891974004939	D-loop; other site
891974004940	H-loop/switch region; other site
891974004941	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
891974004942	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
891974004943	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
891974004944	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
891974004945	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
891974004946	putative active site [active]
891974004947	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
891974004948	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
891974004949	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
891974004950	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
891974004951	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
891974004952	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
891974004953	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
891974004954	Walker A/P-loop; other site
891974004955	ATP binding site [chemical binding]; other site
891974004956	Q-loop/lid; other site
891974004957	ABC transporter signature motif; other site
891974004958	Walker B; other site
891974004959	D-loop; other site
891974004960	H-loop/switch region; other site
891974004961	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
891974004962	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
891974004963	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
891974004964	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
891974004965	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
891974004966	30S subunit binding site; other site
891974004967	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
891974004968	active site
891974004969	phosphorylation site [posttranslational modification]
891974004970	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
891974004971	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
891974004972	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
891974004973	dimerization domain swap beta strand [polypeptide binding]; other site
891974004974	regulatory protein interface [polypeptide binding]; other site
891974004975	active site
891974004976	regulatory phosphorylation site [posttranslational modification]; other site
891974004977	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
891974004978	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
891974004979	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
891974004980	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
891974004981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974004982	putative active site [active]
891974004983	heme pocket [chemical binding]; other site
891974004984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974004985	dimer interface [polypeptide binding]; other site
891974004986	phosphorylation site [posttranslational modification]
891974004987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974004988	ATP binding site [chemical binding]; other site
891974004989	Mg2+ binding site [ion binding]; other site
891974004990	G-X-G motif; other site
891974004991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974004992	active site
891974004993	phosphorylation site [posttranslational modification]
891974004994	intermolecular recognition site; other site
891974004995	dimerization interface [polypeptide binding]; other site
891974004996	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
891974004997	putative binding surface; other site
891974004998	active site
891974004999	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
891974005000	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
891974005001	active site
891974005002	dimer interface [polypeptide binding]; other site
891974005003	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
891974005004	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
891974005005	active site
891974005006	FMN binding site [chemical binding]; other site
891974005007	substrate binding site [chemical binding]; other site
891974005008	3Fe-4S cluster binding site [ion binding]; other site
891974005009	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
891974005010	domain_subunit interface; other site
891974005011	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
891974005012	Flavodoxin; Region: Flavodoxin_1; pfam00258
891974005013	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
891974005014	FAD binding pocket [chemical binding]; other site
891974005015	FAD binding motif [chemical binding]; other site
891974005016	catalytic residues [active]
891974005017	NAD binding pocket [chemical binding]; other site
891974005018	phosphate binding motif [ion binding]; other site
891974005019	beta-alpha-beta structure motif; other site
891974005020	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
891974005021	stringent starvation protein A; Provisional; Region: sspA; PRK09481
891974005022	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
891974005023	C-terminal domain interface [polypeptide binding]; other site
891974005024	putative GSH binding site (G-site) [chemical binding]; other site
891974005025	dimer interface [polypeptide binding]; other site
891974005026	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
891974005027	dimer interface [polypeptide binding]; other site
891974005028	N-terminal domain interface [polypeptide binding]; other site
891974005029	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
891974005030	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
891974005031	23S rRNA interface [nucleotide binding]; other site
891974005032	L3 interface [polypeptide binding]; other site
891974005033	Predicted ATPase [General function prediction only]; Region: COG1485
891974005034	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
891974005035	serine endoprotease; Provisional; Region: PRK10139
891974005036	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
891974005037	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
891974005038	protein binding site [polypeptide binding]; other site
891974005039	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
891974005040	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
891974005041	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
891974005042	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
891974005043	protein binding site [polypeptide binding]; other site
891974005044	poxB regulator PoxA; Provisional; Region: PRK09350
891974005045	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
891974005046	motif 1; other site
891974005047	dimer interface [polypeptide binding]; other site
891974005048	active site
891974005049	motif 2; other site
891974005050	motif 3; other site
891974005051	Entericidin EcnA/B family; Region: Entericidin; cl02322
891974005052	elongation factor P; Validated; Region: PRK00529
891974005053	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
891974005054	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
891974005055	RNA binding site [nucleotide binding]; other site
891974005056	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
891974005057	RNA binding site [nucleotide binding]; other site
891974005058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974005059	Radical SAM superfamily; Region: Radical_SAM; pfam04055
891974005060	FeS/SAM binding site; other site
891974005061	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
891974005062	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
891974005063	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
891974005064	ring oligomerisation interface [polypeptide binding]; other site
891974005065	ATP/Mg binding site [chemical binding]; other site
891974005066	stacking interactions; other site
891974005067	hinge regions; other site
891974005068	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
891974005069	oligomerisation interface [polypeptide binding]; other site
891974005070	mobile loop; other site
891974005071	roof hairpin; other site
891974005072	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502
891974005073	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
891974005074	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
891974005075	Aspartase; Region: Aspartase; cd01357
891974005076	active sites [active]
891974005077	tetramer interface [polypeptide binding]; other site
891974005078	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
891974005079	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
891974005080	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
891974005081	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
891974005082	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
891974005083	DsbD alpha interface [polypeptide binding]; other site
891974005084	catalytic residues [active]
891974005085	putative transcriptional regulator; Provisional; Region: PRK11640
891974005086	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
891974005087	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
891974005088	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
891974005089	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
891974005090	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
891974005091	DHHA2 domain; Region: DHHA2; pfam02833
891974005092	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
891974005093	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
891974005094	Enolase, C-terminal TIM barrel domain; Region: Enolase_C; pfam00113
891974005095	metal binding site [ion binding]; metal-binding site
891974005096	substrate binding pocket [chemical binding]; other site
891974005097	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
891974005098	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
891974005099	CrcB-like protein; Region: CRCB; cl09114
891974005100	CrcB-like protein; Region: CRCB; cl09114
891974005101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974005102	Transposase; Region: HTH_Tnp_1; cl17663
891974005103	Integrase core domain; Region: rve; pfam00665
891974005104	Integrase core domain; Region: rve_3; pfam13683
891974005105	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
891974005106	potassium transporter; Provisional; Region: PRK10750
891974005107	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
891974005108	hypothetical protein; Provisional; Region: PRK11568
891974005109	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
891974005110	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
891974005111	proline dipeptidase; Provisional; Region: PRK13607
891974005112	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
891974005113	active site
891974005114	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
891974005115	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
891974005116	substrate binding site [chemical binding]; other site
891974005117	oxyanion hole (OAH) forming residues; other site
891974005118	trimer interface [polypeptide binding]; other site
891974005119	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
891974005120	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
891974005121	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
891974005122	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
891974005123	dimer interface [polypeptide binding]; other site
891974005124	active site
891974005125	FMN reductase; Validated; Region: fre; PRK08051
891974005126	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
891974005127	FAD binding pocket [chemical binding]; other site
891974005128	FAD binding motif [chemical binding]; other site
891974005129	phosphate binding motif [ion binding]; other site
891974005130	beta-alpha-beta structure motif; other site
891974005131	NAD binding pocket [chemical binding]; other site
891974005132	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
891974005133	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974005134	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974005135	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
891974005136	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
891974005137	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974005138	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
891974005139	active site
891974005140	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
891974005141	sec-independent translocase; Provisional; Region: tatB; PRK00404
891974005142	sec-independent translocase; Provisional; Region: PRK01770
891974005143	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
891974005144	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
891974005145	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
891974005146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
891974005147	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
891974005148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974005149	S-adenosylmethionine binding site [chemical binding]; other site
891974005150	DNA recombination protein RmuC; Provisional; Region: PRK10361
891974005151	RmuC family; Region: RmuC; pfam02646
891974005152	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
891974005153	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
891974005154	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
891974005155	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
891974005156	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
891974005157	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
891974005158	THF binding site; other site
891974005159	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
891974005160	substrate binding site [chemical binding]; other site
891974005161	THF binding site; other site
891974005162	zinc-binding site [ion binding]; other site
891974005163	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
891974005164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974005165	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
891974005166	putative dimerization interface [polypeptide binding]; other site
891974005167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
891974005168	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
891974005169	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
891974005170	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
891974005171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005172	putative hydrolase; Provisional; Region: PRK10976
891974005173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974005174	active site
891974005175	motif I; other site
891974005176	motif II; other site
891974005177	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974005178	lysophospholipase L2; Provisional; Region: PRK10749
891974005179	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
891974005180	threonine efflux system; Provisional; Region: PRK10229
891974005181	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
891974005182	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974005183	ATP binding site [chemical binding]; other site
891974005184	putative Mg++ binding site [ion binding]; other site
891974005185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974005186	nucleotide binding region [chemical binding]; other site
891974005187	ATP-binding site [chemical binding]; other site
891974005188	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
891974005189	HRDC domain; Region: HRDC; pfam00570
891974005190	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
891974005191	dimerization interface [polypeptide binding]; other site
891974005192	substrate binding site [chemical binding]; other site
891974005193	active site
891974005194	calcium binding site [ion binding]; other site
891974005195	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
891974005196	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
891974005197	CoenzymeA binding site [chemical binding]; other site
891974005198	subunit interaction site [polypeptide binding]; other site
891974005199	PHB binding site; other site
891974005200	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
891974005201	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
891974005202	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
891974005203	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
891974005204	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
891974005205	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
891974005206	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
891974005207	Cl binding site [ion binding]; other site
891974005208	oligomer interface [polypeptide binding]; other site
891974005209	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
891974005210	Part of AAA domain; Region: AAA_19; pfam13245
891974005211	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
891974005212	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974005213	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
891974005214	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974005215	motif II; other site
891974005216	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
891974005217	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974005218	active site
891974005219	DNA binding site [nucleotide binding]
891974005220	Int/Topo IB signature motif; other site
891974005221	hypothetical protein; Provisional; Region: PRK10963
891974005222	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
891974005223	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
891974005224	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
891974005225	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
891974005226	adenylate cyclase; Provisional; Region: cyaA; PRK09450
891974005227	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
891974005228	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
891974005229	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
891974005230	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
891974005231	domain interfaces; other site
891974005232	active site
891974005233	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
891974005234	active site
891974005235	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
891974005236	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
891974005237	HemY protein N-terminus; Region: HemY_N; pfam07219
891974005238	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
891974005239	putative common antigen polymerase; Provisional; Region: PRK02975
891974005240	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
891974005241	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
891974005242	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
891974005243	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
891974005244	inhibitor-cofactor binding pocket; inhibition site
891974005245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005246	catalytic residue [active]
891974005247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974005248	Coenzyme A binding pocket [chemical binding]; other site
891974005249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974005250	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
891974005251	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
891974005252	substrate binding site; other site
891974005253	tetramer interface; other site
891974005254	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
891974005255	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
891974005256	NAD binding site [chemical binding]; other site
891974005257	substrate binding site [chemical binding]; other site
891974005258	homodimer interface [polypeptide binding]; other site
891974005259	active site
891974005260	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
891974005261	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
891974005262	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
891974005263	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
891974005264	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
891974005265	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
891974005266	active site
891974005267	homodimer interface [polypeptide binding]; other site
891974005268	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
891974005269	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
891974005270	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
891974005271	Mg++ binding site [ion binding]; other site
891974005272	putative catalytic motif [active]
891974005273	transcription termination factor Rho; Provisional; Region: rho; PRK09376
891974005274	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
891974005275	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
891974005276	RNA binding site [nucleotide binding]; other site
891974005277	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
891974005278	multimer interface [polypeptide binding]; other site
891974005279	Walker A motif; other site
891974005280	ATP binding site [chemical binding]; other site
891974005281	Walker B motif; other site
891974005282	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
891974005283	catalytic residues [active]
891974005284	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
891974005285	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
891974005286	ATP binding site [chemical binding]; other site
891974005287	Mg++ binding site [ion binding]; other site
891974005288	motif III; other site
891974005289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974005290	nucleotide binding region [chemical binding]; other site
891974005291	ATP-binding site [chemical binding]; other site
891974005292	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
891974005293	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
891974005294	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
891974005295	Part of AAA domain; Region: AAA_19; pfam13245
891974005296	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
891974005297	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
891974005298	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
891974005299	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
891974005300	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
891974005301	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974005302	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974005303	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
891974005304	substrate binding site [chemical binding]; other site
891974005305	ATP binding site [chemical binding]; other site
891974005306	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
891974005307	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
891974005308	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
891974005309	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
891974005310	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
891974005311	HAMP domain; Region: HAMP; pfam00672
891974005312	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974005313	metal binding site [ion binding]; metal-binding site
891974005314	active site
891974005315	I-site; other site
891974005316	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974005317	putative diguanylate cyclase; Provisional; Region: PRK13561
891974005318	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
891974005319	Protein of unknown function (DUF2819); Region: DUF2819; cl17862
891974005320	Protein of unknown function (DUF2819); Region: DUF2819; cl17862
891974005321	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
891974005322	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974005323	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974005324	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974005325	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
891974005326	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
891974005327	DXD motif; other site
891974005328	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
891974005329	PilZ domain; Region: PilZ; pfam07238
891974005330	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005331	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005332	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005333	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
891974005334	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
891974005335	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
891974005336	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
891974005337	Protein of unknown function (DUF497); Region: DUF497; cl01108
891974005338	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
891974005339	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
891974005340	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
891974005341	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
891974005342	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005343	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
891974005344	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005345	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005346	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
891974005347	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
891974005348	PilZ domain; Region: PilZ; pfam07238
891974005349	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
891974005350	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974005351	Walker A/P-loop; other site
891974005352	ATP binding site [chemical binding]; other site
891974005353	Q-loop/lid; other site
891974005354	ABC transporter signature motif; other site
891974005355	Walker B; other site
891974005356	D-loop; other site
891974005357	H-loop/switch region; other site
891974005358	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974005359	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
891974005360	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974005361	Walker A/P-loop; other site
891974005362	ATP binding site [chemical binding]; other site
891974005363	Q-loop/lid; other site
891974005364	ABC transporter signature motif; other site
891974005365	Walker B; other site
891974005366	D-loop; other site
891974005367	H-loop/switch region; other site
891974005368	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974005369	dipeptide transporter; Provisional; Region: PRK10913
891974005370	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974005371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005372	dimer interface [polypeptide binding]; other site
891974005373	conserved gate region; other site
891974005374	putative PBP binding loops; other site
891974005375	ABC-ATPase subunit interface; other site
891974005376	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
891974005377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005378	dimer interface [polypeptide binding]; other site
891974005379	conserved gate region; other site
891974005380	putative PBP binding loops; other site
891974005381	ABC-ATPase subunit interface; other site
891974005382	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974005383	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
891974005384	peptide binding site [polypeptide binding]; other site
891974005385	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974005386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974005387	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974005388	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974005389	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974005390	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
891974005391	catalytic core [active]
891974005392	Protein of unknown function DUF84; Region: NTPase_I-T; cl00866
891974005393	Protein of unknown function DUF84; Region: NTPase_I-T; cl00866
891974005394	Trp operon repressor; Provisional; Region: PRK01381
891974005395	lytic murein transglycosylase; Provisional; Region: PRK11619
891974005396	Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718
891974005397	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974005398	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974005399	catalytic residue [active]
891974005400	allophanate hydrolase; Provisional; Region: PRK08186
891974005401	urea carboxylase; Region: urea_carbox; TIGR02712
891974005402	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
891974005403	ATP-grasp domain; Region: ATP-grasp_4; cl17255
891974005404	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
891974005405	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
891974005406	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
891974005407	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
891974005408	carboxyltransferase (CT) interaction site; other site
891974005409	biotinylation site [posttranslational modification]; other site
891974005410	Transcriptional regulators [Transcription]; Region: GntR; COG1802
891974005411	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974005412	DNA-binding site [nucleotide binding]; DNA binding site
891974005413	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
891974005414	FCD domain; Region: FCD; pfam07729
891974005415	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974005416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974005417	Transposase; Region: HTH_Tnp_1; cl17663
891974005418	Integrase core domain; Region: rve; pfam00665
891974005419	Integrase core domain; Region: rve_3; pfam13683
891974005420	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
891974005421	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
891974005422	active site
891974005423	dimer interface [polypeptide binding]; other site
891974005424	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
891974005425	dimer interface [polypeptide binding]; other site
891974005426	active site
891974005427	aspartate kinase III; Validated; Region: PRK09084
891974005428	AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
891974005429	nucleotide binding site [chemical binding]; other site
891974005430	putative catalytic residues [active]
891974005431	aspartate binding site [chemical binding]; other site
891974005432	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
891974005433	lysine allosteric regulatory site; other site
891974005434	dimer interface [polypeptide binding]; other site
891974005435	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
891974005436	dimer interface [polypeptide binding]; other site
891974005437	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
891974005438	putative antibiotic transporter; Provisional; Region: PRK10739
891974005439	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
891974005440	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
891974005441	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
891974005442	glycogen branching enzyme; Provisional; Region: PRK05402
891974005443	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
891974005444	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
891974005445	active site
891974005446	catalytic site [active]
891974005447	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
891974005448	glycogen debranching enzyme; Provisional; Region: PRK03705
891974005449	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
891974005450	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
891974005451	active site
891974005452	catalytic site [active]
891974005453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974005454	active site
891974005455	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974005456	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
891974005457	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
891974005458	dimer interface [polypeptide binding]; other site
891974005459	N-terminal domain interface [polypeptide binding]; other site
891974005460	sulfate 1 binding site; other site
891974005461	glycogen synthase; Provisional; Region: glgA; PRK00654
891974005462	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
891974005463	ADP-binding pocket [chemical binding]; other site
891974005464	homodimer interface [polypeptide binding]; other site
891974005465	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974005466	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974005467	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974005468	YfaZ precursor; Region: YfaZ; pfam07437
891974005469	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974005470	dimerization interface [polypeptide binding]; other site
891974005471	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974005472	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
891974005473	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
891974005474	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
891974005475	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
891974005476	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
891974005477	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
891974005478	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
891974005479	putative C-terminal domain interface [polypeptide binding]; other site
891974005480	putative GSH binding site (G-site) [chemical binding]; other site
891974005481	putative dimer interface [polypeptide binding]; other site
891974005482	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
891974005483	putative N-terminal domain interface [polypeptide binding]; other site
891974005484	putative dimer interface [polypeptide binding]; other site
891974005485	putative substrate binding pocket (H-site) [chemical binding]; other site
891974005486	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
891974005487	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
891974005488	DNA binding residues [nucleotide binding]
891974005489	dimer interface [polypeptide binding]; other site
891974005490	[2Fe-2S] cluster binding site [ion binding]; other site
891974005491	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
891974005492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974005493	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
891974005494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974005495	Transposase; Region: HTH_Tnp_1; cl17663
891974005496	Integrase core domain; Region: rve; pfam00665
891974005497	Integrase core domain; Region: rve_3; pfam13683
891974005498	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974005499	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974005500	hypothetical protein; Provisional; Region: PRK11667
891974005501	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
891974005502	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974005503	DNA-binding site [nucleotide binding]; DNA binding site
891974005504	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974005505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005506	homodimer interface [polypeptide binding]; other site
891974005507	catalytic residue [active]
891974005508	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
891974005509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974005510	Coenzyme A binding pocket [chemical binding]; other site
891974005511	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974005512	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
891974005513	Uncharacterized conserved protein [Function unknown]; Region: COG2128
891974005514	inner membrane protein; Provisional; Region: PRK10995
891974005515	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974005516	Cytochrome c; Region: Cytochrom_C; cl11414
891974005517	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974005518	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
891974005519	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974005520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974005521	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974005522	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974005523	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
891974005524	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974005525	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
891974005526	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974005527	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
891974005528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974005529	DNA-binding site [nucleotide binding]; DNA binding site
891974005530	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974005531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005532	homodimer interface [polypeptide binding]; other site
891974005533	catalytic residue [active]
891974005534	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974005535	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974005536	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974005537	metal binding site [ion binding]; metal-binding site
891974005538	active site
891974005539	I-site; other site
891974005540	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
891974005541	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
891974005542	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
891974005543	PapC N-terminal domain; Region: PapC_N; pfam13954
891974005544	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
891974005545	Outer membrane usher protein; Region: Usher; pfam00577
891974005546	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
891974005547	Outer membrane usher protein; Region: Usher; pfam00577
891974005548	PapC C-terminal domain; Region: PapC_C; pfam13953
891974005549	Spore Coat Protein U domain; Region: SCPU; cl02253
891974005550	Spore Coat Protein U domain; Region: SCPU; pfam05229
891974005551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005552	putative substrate translocation pore; other site
891974005553	citrate-proton symporter; Provisional; Region: PRK15075
891974005554	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974005555	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974005556	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974005557	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974005558	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974005559	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974005560	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
891974005561	metal binding site [ion binding]; metal-binding site
891974005562	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974005563	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
891974005564	active site
891974005565	non-prolyl cis peptide bond; other site
891974005566	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
891974005567	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974005568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974005569	substrate binding pocket [chemical binding]; other site
891974005570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974005571	Coenzyme A binding pocket [chemical binding]; other site
891974005572	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974005573	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974005574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005575	putative PBP binding loops; other site
891974005576	dimer interface [polypeptide binding]; other site
891974005577	ABC-ATPase subunit interface; other site
891974005578	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974005579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974005580	Walker A/P-loop; other site
891974005581	ATP binding site [chemical binding]; other site
891974005582	Q-loop/lid; other site
891974005583	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974005584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974005585	ABC transporter signature motif; other site
891974005586	Walker B; other site
891974005587	D-loop; other site
891974005588	H-loop/switch region; other site
891974005589	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974005590	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
891974005591	active site
891974005592	dimerization interface [polypeptide binding]; other site
891974005593	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
891974005594	YebG protein; Region: YebG; pfam07130
891974005595	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
891974005596	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974005597	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
891974005598	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
891974005599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005600	putative substrate translocation pore; other site
891974005601	putative cyanate transporter; Provisional; Region: cynX; PRK09705
891974005602	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
891974005603	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
891974005604	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
891974005605	NADP binding site [chemical binding]; other site
891974005606	active site
891974005607	steroid binding site; other site
891974005608	Cupin; Region: Cupin_6; pfam12852
891974005609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974005610	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974005611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974005612	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
891974005613	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
891974005614	tetrameric interface [polypeptide binding]; other site
891974005615	NAD binding site [chemical binding]; other site
891974005616	catalytic residues [active]
891974005617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974005618	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974005619	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974005620	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974005621	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974005622	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974005623	Coenzyme A binding pocket [chemical binding]; other site
891974005624	aminotransferase; Validated; Region: PRK08175
891974005625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974005626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005627	homodimer interface [polypeptide binding]; other site
891974005628	catalytic residue [active]
891974005629	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974005630	Bacterial transcriptional regulator; Region: IclR; pfam01614
891974005631	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974005632	Ligand Binding Site [chemical binding]; other site
891974005633	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
891974005634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005635	putative substrate translocation pore; other site
891974005636	ImpA domain protein; Region: DUF3702; pfam12486
891974005637	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
891974005638	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
891974005639	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
891974005640	Walker A/P-loop; other site
891974005641	ATP binding site [chemical binding]; other site
891974005642	Q-loop/lid; other site
891974005643	ABC transporter signature motif; other site
891974005644	Walker B; other site
891974005645	D-loop; other site
891974005646	H-loop/switch region; other site
891974005647	CcmB protein; Region: CcmB; cl17444
891974005648	heme exporter protein CcmC; Region: ccmC; TIGR01191
891974005649	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
891974005650	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
891974005651	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
891974005652	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
891974005653	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
891974005654	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
891974005655	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
891974005656	catalytic residues [active]
891974005657	central insert; other site
891974005658	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
891974005659	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
891974005660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974005661	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
891974005662	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
891974005663	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
891974005664	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
891974005665	Protein of unknown function (DUF406); Region: DUF406; cl11449
891974005666	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
891974005667	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
891974005668	dimer interface [polypeptide binding]; other site
891974005669	active site
891974005670	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
891974005671	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
891974005672	substrate binding site [chemical binding]; other site
891974005673	oxyanion hole (OAH) forming residues; other site
891974005674	trimer interface [polypeptide binding]; other site
891974005675	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
891974005676	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
891974005677	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
891974005678	Flagellar L-ring protein; Region: FlgH; cl19182
891974005679	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
891974005680	catalytic core [active]
891974005681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
891974005682	hypothetical protein; Provisional; Region: PRK04946
891974005683	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805
891974005684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974005685	S-adenosylmethionine binding site [chemical binding]; other site
891974005686	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
891974005687	Tetramer interface [polypeptide binding]; other site
891974005688	active site
891974005689	FMN-binding site [chemical binding]; other site
891974005690	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
891974005691	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
891974005692	hypothetical protein; Provisional; Region: PRK10621
891974005693	Protein of unknown function, DUF462; Region: DUF462; cl01190
891974005694	YfcL protein; Region: YfcL; pfam08891
891974005695	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
891974005696	Uncharacterized conserved protein [Function unknown]; Region: COG4121
891974005697	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
891974005698	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
891974005699	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
891974005700	dimer interface [polypeptide binding]; other site
891974005701	active site
891974005702	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974005703	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
891974005704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005705	homodimer interface [polypeptide binding]; other site
891974005706	catalytic residue [active]
891974005707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
891974005708	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
891974005709	active site residue [active]
891974005710	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
891974005711	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
891974005712	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
891974005713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
891974005714	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
891974005715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974005716	active site
891974005717	phosphorylation site [posttranslational modification]
891974005718	intermolecular recognition site; other site
891974005719	dimerization interface [polypeptide binding]; other site
891974005720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
891974005721	DNA binding site [nucleotide binding]
891974005722	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
891974005723	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
891974005724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974005725	dimer interface [polypeptide binding]; other site
891974005726	phosphorylation site [posttranslational modification]
891974005727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974005728	ATP binding site [chemical binding]; other site
891974005729	Mg2+ binding site [ion binding]; other site
891974005730	G-X-G motif; other site
891974005731	EamA-like transporter family; Region: EamA; pfam00892
891974005732	Cupin domain; Region: Cupin_2; cl17218
891974005733	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974005734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974005735	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
891974005736	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
891974005737	ligand binding site [chemical binding]; other site
891974005738	NAD binding site [chemical binding]; other site
891974005739	catalytic site [active]
891974005740	homodimer interface [polypeptide binding]; other site
891974005741	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
891974005742	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
891974005743	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
891974005744	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
891974005745	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
891974005746	dimerization interface 3.5A [polypeptide binding]; other site
891974005747	active site
891974005748	hypothetical protein; Provisional; Region: PRK10847
891974005749	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
891974005750	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
891974005751	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
891974005752	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
891974005753	cell division protein DedD; Provisional; Region: PRK11633
891974005754	Sporulation related domain; Region: SPOR; pfam05036
891974005755	colicin V production protein; Provisional; Region: PRK10845
891974005756	amidophosphoribosyltransferase; Provisional; Region: PRK09246
891974005757	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
891974005758	active site
891974005759	tetramer interface [polypeptide binding]; other site
891974005760	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974005761	active site
891974005762	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
891974005763	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
891974005764	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974005765	substrate binding pocket [chemical binding]; other site
891974005766	membrane-bound complex binding site; other site
891974005767	hinge residues; other site
891974005768	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
891974005769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005770	dimer interface [polypeptide binding]; other site
891974005771	conserved gate region; other site
891974005772	putative PBP binding loops; other site
891974005773	ABC-ATPase subunit interface; other site
891974005774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974005775	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974005776	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974005777	nucleotide binding site [chemical binding]; other site
891974005778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005779	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974005780	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
891974005781	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
891974005782	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
891974005783	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974005784	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
891974005785	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974005786	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974005787	NAD binding site [chemical binding]; other site
891974005788	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
891974005789	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
891974005790	classical (c) SDRs; Region: SDR_c; cd05233
891974005791	NAD(P) binding site [chemical binding]; other site
891974005792	active site
891974005793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
891974005794	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974005795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974005796	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
891974005797	dimerization interface [polypeptide binding]; other site
891974005798	substrate binding pocket [chemical binding]; other site
891974005799	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
891974005800	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
891974005801	putative NAD(P) binding site [chemical binding]; other site
891974005802	putative active site [active]
891974005803	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974005804	substrate binding pocket (H-site) [chemical binding]; other site
891974005805	N-terminal domain interface [polypeptide binding]; other site
891974005806	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
891974005807	nudix motif; other site
891974005808	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974005809	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974005810	inhibitor-cofactor binding pocket; inhibition site
891974005811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005812	catalytic residue [active]
891974005813	phosphate acetyltransferase; Reviewed; Region: PRK05632
891974005814	DRTGG domain; Region: DRTGG; pfam07085
891974005815	phosphate acetyltransferase; Region: pta; TIGR00651
891974005816	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
891974005817	hypothetical protein; Provisional; Region: PRK01816
891974005818	hypothetical protein; Validated; Region: PRK05445
891974005819	putative phosphatase; Provisional; Region: PRK11587
891974005820	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974005821	active site
891974005822	motif I; other site
891974005823	motif II; other site
891974005824	5'-nucleotidase; Provisional; Region: PRK03826
891974005825	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974005826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974005827	homodimer interface [polypeptide binding]; other site
891974005828	catalytic residue [active]
891974005829	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974005830	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
891974005831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974005832	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
891974005833	putative dimerization interface [polypeptide binding]; other site
891974005834	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
891974005835	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
891974005836	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
891974005837	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
891974005838	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
891974005839	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
891974005840	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
891974005841	putative dimer interface [polypeptide binding]; other site
891974005842	[2Fe-2S] cluster binding site [ion binding]; other site
891974005843	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
891974005844	SLBB domain; Region: SLBB; pfam10531
891974005845	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
891974005846	CP12 domain; Region: CP12; cl14670
891974005847	NADH dehydrogenase subunit G; Validated; Region: PRK08166
891974005848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974005849	catalytic loop [active]
891974005850	iron binding site [ion binding]; other site
891974005851	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
891974005852	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
891974005853	[4Fe-4S] binding site [ion binding]; other site
891974005854	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
891974005855	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
891974005856	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
891974005857	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
891974005858	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
891974005859	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
891974005860	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
891974005861	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
891974005862	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
891974005863	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
891974005864	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
891974005865	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
891974005866	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
891974005867	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
891974005868	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974005869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974005870	Coenzyme A binding pocket [chemical binding]; other site
891974005871	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
891974005872	hypothetical protein; Provisional; Region: PRK10404
891974005873	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
891974005874	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
891974005875	hypothetical protein; Provisional; Region: PRK03673
891974005876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974005877	catalytic loop [active]
891974005878	iron binding site [ion binding]; other site
891974005879	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
891974005880	dimer interface [polypeptide binding]; other site
891974005881	putative radical transfer pathway; other site
891974005882	diiron center [ion binding]; other site
891974005883	tyrosyl radical; other site
891974005884	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
891974005885	ATP cone domain; Region: ATP-cone; pfam03477
891974005886	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
891974005887	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
891974005888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974005889	S-adenosylmethionine binding site [chemical binding]; other site
891974005890	DNA gyrase subunit A; Validated; Region: PRK05560
891974005891	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
891974005892	CAP-like domain; other site
891974005893	active site
891974005894	primary dimer interface [polypeptide binding]; other site
891974005895	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005896	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005897	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005898	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005899	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005900	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974005901	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
891974005902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974005903	dimer interface [polypeptide binding]; other site
891974005904	phosphorylation site [posttranslational modification]
891974005905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974005906	ATP binding site [chemical binding]; other site
891974005907	Mg2+ binding site [ion binding]; other site
891974005908	G-X-G motif; other site
891974005909	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
891974005910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974005911	active site
891974005912	phosphorylation site [posttranslational modification]
891974005913	intermolecular recognition site; other site
891974005914	dimerization interface [polypeptide binding]; other site
891974005915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974005916	ATP binding site [chemical binding]; other site
891974005917	Mg2+ binding site [ion binding]; other site
891974005918	G-X-G motif; other site
891974005919	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
891974005920	putative binding surface; other site
891974005921	active site
891974005922	transcriptional regulator RcsB; Provisional; Region: PRK10840
891974005923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974005924	active site
891974005925	phosphorylation site [posttranslational modification]
891974005926	intermolecular recognition site; other site
891974005927	dimerization interface [polypeptide binding]; other site
891974005928	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974005929	DNA binding residues [nucleotide binding]
891974005930	dimerization interface [polypeptide binding]; other site
891974005931	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
891974005932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005933	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974005934	putative substrate translocation pore; other site
891974005935	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974005936	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974005937	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974005938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974005939	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
891974005940	ApbE family; Region: ApbE; cl19294
891974005941	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
891974005942	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
891974005943	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974005944	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
891974005945	Walker A/P-loop; other site
891974005946	ATP binding site [chemical binding]; other site
891974005947	Q-loop/lid; other site
891974005948	ABC transporter signature motif; other site
891974005949	Walker B; other site
891974005950	D-loop; other site
891974005951	H-loop/switch region; other site
891974005952	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
891974005953	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
891974005954	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
891974005955	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
891974005956	Sulfatase; Region: Sulfatase; cl19157
891974005957	hypothetical protein; Provisional; Region: PRK13689
891974005958	nucleoid-associated protein NdpA; Validated; Region: PRK00378
891974005959	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
891974005960	5S rRNA interface [nucleotide binding]; other site
891974005961	CTC domain interface [polypeptide binding]; other site
891974005962	L16 interface [polypeptide binding]; other site
891974005963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974005964	nucleotide binding region [chemical binding]; other site
891974005965	ATP-binding site [chemical binding]; other site
891974005966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974005967	putative Mg++ binding site [ion binding]; other site
891974005968	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974005969	RNA binding surface [nucleotide binding]; other site
891974005970	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
891974005971	active site
891974005972	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
891974005973	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
891974005974	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
891974005975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974005976	YejG-like protein; Region: YejG; cl08201
891974005977	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974005978	Q-loop/lid; other site
891974005979	ABC transporter signature motif; other site
891974005980	Walker B; other site
891974005981	D-loop; other site
891974005982	H-loop/switch region; other site
891974005983	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974005984	Walker A/P-loop; other site
891974005985	ATP binding site [chemical binding]; other site
891974005986	Q-loop/lid; other site
891974005987	ABC transporter signature motif; other site
891974005988	Walker B; other site
891974005989	D-loop; other site
891974005990	microcin C ABC transporter permease; Provisional; Region: PRK15021
891974005991	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974005992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005993	dimer interface [polypeptide binding]; other site
891974005994	conserved gate region; other site
891974005995	putative PBP binding loops; other site
891974005996	ABC-ATPase subunit interface; other site
891974005997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974005998	putative PBP binding loops; other site
891974005999	dimer interface [polypeptide binding]; other site
891974006000	ABC-ATPase subunit interface; other site
891974006001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974006002	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974006003	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
891974006004	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
891974006005	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974006006	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
891974006007	NlpC/P60 family; Region: NLPC_P60; pfam00877
891974006008	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
891974006009	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
891974006010	active site
891974006011	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
891974006012	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
891974006013	elongation factor P; Provisional; Region: PRK04542
891974006014	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
891974006015	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
891974006016	RNA binding site [nucleotide binding]; other site
891974006017	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
891974006018	RNA binding site [nucleotide binding]; other site
891974006019	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
891974006020	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
891974006021	active site
891974006022	phosphorylation site [posttranslational modification]
891974006023	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
891974006024	dimerization domain swap beta strand [polypeptide binding]; other site
891974006025	regulatory protein interface [polypeptide binding]; other site
891974006026	active site
891974006027	regulatory phosphorylation site [posttranslational modification]; other site
891974006028	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
891974006029	putative substrate binding site [chemical binding]; other site
891974006030	putative ATP binding site [chemical binding]; other site
891974006031	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
891974006032	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
891974006033	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
891974006034	active site
891974006035	P-loop; other site
891974006036	phosphorylation site [posttranslational modification]
891974006037	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
891974006038	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
891974006039	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
891974006040	AP (apurinic/apyrimidinic) site pocket; other site
891974006041	DNA interaction; other site
891974006042	Metal-binding active site; metal-binding site
891974006043	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
891974006044	Uncharacterized conserved protein [Function unknown]; Region: COG3339
891974006045	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
891974006046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974006047	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
891974006048	putative dimerization interface [polypeptide binding]; other site
891974006049	lysine transporter; Provisional; Region: PRK10836
891974006050	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
891974006051	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
891974006052	ABC-ATPase subunit  interface; other site
891974006053	dimer interface [polypeptide binding]; other site
891974006054	putative PBP binding regions; other site
891974006055	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
891974006056	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
891974006057	Walker A/P-loop; other site
891974006058	ATP binding site [chemical binding]; other site
891974006059	Q-loop/lid; other site
891974006060	ABC transporter signature motif; other site
891974006061	Walker B; other site
891974006062	D-loop; other site
891974006063	H-loop/switch region; other site
891974006064	Predicted esterase [General function prediction only]; Region: COG0627
891974006065	S-formylglutathione hydrolase; Region: PLN02442
891974006066	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974006067	NAD(P) binding site [chemical binding]; other site
891974006068	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974006069	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974006070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974006071	dimerization interface [polypeptide binding]; other site
891974006072	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
891974006073	active site
891974006074	Protein of unknown function (DUF418); Region: DUF418; cl12135
891974006075	Protein of unknown function (DUF418); Region: DUF418; cl12135
891974006076	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
891974006077	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974006078	DNA binding site [nucleotide binding]
891974006079	domain linker motif; other site
891974006080	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
891974006081	dimerization interface (closed form) [polypeptide binding]; other site
891974006082	ligand binding site [chemical binding]; other site
891974006083	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
891974006084	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
891974006085	ligand binding site [chemical binding]; other site
891974006086	calcium binding site [ion binding]; other site
891974006087	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974006088	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
891974006089	Walker A/P-loop; other site
891974006090	ATP binding site [chemical binding]; other site
891974006091	Q-loop/lid; other site
891974006092	ABC transporter signature motif; other site
891974006093	Walker B; other site
891974006094	D-loop; other site
891974006095	H-loop/switch region; other site
891974006096	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
891974006097	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974006098	TM-ABC transporter signature motif; other site
891974006099	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
891974006100	putative active site [active]
891974006101	malate dehydrogenase; Provisional; Region: PRK13529
891974006102	Malic enzyme, N-terminal domain; Region: malic; pfam00390
891974006103	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
891974006104	NAD(P) binding site [chemical binding]; other site
891974006105	cytidine deaminase; Provisional; Region: PRK09027
891974006106	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
891974006107	active site
891974006108	catalytic motif [active]
891974006109	Zn binding site [ion binding]; other site
891974006110	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
891974006111	active site
891974006112	catalytic motif [active]
891974006113	Zn binding site [ion binding]; other site
891974006114	LrgB-like family; Region: LrgB; cl00596
891974006115	hypothetical protein; Provisional; Region: PRK01821
891974006116	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
891974006117	putative active site [active]
891974006118	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
891974006119	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
891974006120	active site
891974006121	KMSKS motif; other site
891974006122	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
891974006123	tRNA binding surface [nucleotide binding]; other site
891974006124	anticodon binding site; other site
891974006125	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
891974006126	dimer interface [polypeptide binding]; other site
891974006127	putative tRNA-binding site [nucleotide binding]; other site
891974006128	antiporter inner membrane protein; Provisional; Region: PRK11670
891974006129	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
891974006130	Walker A motif; other site
891974006131	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
891974006132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974006133	Coenzyme A binding pocket [chemical binding]; other site
891974006134	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
891974006135	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
891974006136	dimer interface [polypeptide binding]; other site
891974006137	decamer (pentamer of dimers) interface [polypeptide binding]; other site
891974006138	catalytic triad [active]
891974006139	peroxidatic and resolving cysteines [active]
891974006140	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
891974006141	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
891974006142	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
891974006143	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
891974006144	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974006145	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974006146	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
891974006147	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
891974006148	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
891974006149	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
891974006150	active site
891974006151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974006152	putative substrate translocation pore; other site
891974006153	D-galactonate transporter; Region: 2A0114; TIGR00893
891974006154	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
891974006155	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974006156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
891974006157	dimerization interface [polypeptide binding]; other site
891974006158	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
891974006159	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
891974006160	[2Fe-2S] cluster binding site [ion binding]; other site
891974006161	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
891974006162	hydrophobic ligand binding site; other site
891974006163	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
891974006164	conserved FAD binding motif [chemical binding]; other site
891974006165	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
891974006166	phosphate binding motif [ion binding]; other site
891974006167	beta-alpha-beta structure motif; other site
891974006168	NAD binding pocket [chemical binding]; other site
891974006169	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974006170	catalytic loop [active]
891974006171	iron binding site [ion binding]; other site
891974006172	Domain of unknown function (DUF892); Region: DUF892; cl17410
891974006173	General stress protein [General function prediction only]; Region: GsiB; COG3729
891974006174	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
891974006175	dimerization interface [polypeptide binding]; other site
891974006176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974006177	NAD(P) binding site [chemical binding]; other site
891974006178	active site
891974006179	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974006180	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974006181	NAD(P) binding site [chemical binding]; other site
891974006182	catalytic residues [active]
891974006183	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974006184	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
891974006185	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
891974006186	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
891974006187	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
891974006188	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
891974006189	active site
891974006190	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
891974006191	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974006192	metal binding site [ion binding]; metal-binding site
891974006193	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974006194	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
891974006195	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974006196	Walker A/P-loop; other site
891974006197	ATP binding site [chemical binding]; other site
891974006198	Q-loop/lid; other site
891974006199	ABC transporter signature motif; other site
891974006200	Walker B; other site
891974006201	D-loop; other site
891974006202	H-loop/switch region; other site
891974006203	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
891974006204	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
891974006205	Walker A/P-loop; other site
891974006206	ATP binding site [chemical binding]; other site
891974006207	Q-loop/lid; other site
891974006208	ABC transporter signature motif; other site
891974006209	Walker B; other site
891974006210	D-loop; other site
891974006211	H-loop/switch region; other site
891974006212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974006213	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
891974006214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006215	dimer interface [polypeptide binding]; other site
891974006216	conserved gate region; other site
891974006217	putative PBP binding loops; other site
891974006218	ABC-ATPase subunit interface; other site
891974006219	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
891974006220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006221	dimer interface [polypeptide binding]; other site
891974006222	conserved gate region; other site
891974006223	putative PBP binding loops; other site
891974006224	ABC-ATPase subunit interface; other site
891974006225	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974006226	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974006227	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974006228	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974006229	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
891974006230	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
891974006231	metal binding site [ion binding]; metal-binding site
891974006232	dimer interface [polypeptide binding]; other site
891974006233	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974006234	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
891974006235	DNA-binding site [nucleotide binding]; DNA binding site
891974006236	UTRA domain; Region: UTRA; pfam07702
891974006237	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
891974006238	MASE2 domain; Region: MASE2; pfam05230
891974006239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974006240	metal binding site [ion binding]; metal-binding site
891974006241	active site
891974006242	I-site; other site
891974006243	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
891974006244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974006245	dimer interface [polypeptide binding]; other site
891974006246	putative CheW interface [polypeptide binding]; other site
891974006247	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
891974006248	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974006249	dimerization interface [polypeptide binding]; other site
891974006250	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
891974006251	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974006252	NAD(P) binding site [chemical binding]; other site
891974006253	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974006254	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974006255	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
891974006256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974006257	active site
891974006258	motif I; other site
891974006259	motif II; other site
891974006260	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
891974006261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974006262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974006263	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
891974006264	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
891974006265	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
891974006266	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
891974006267	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
891974006268	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974006269	intersubunit interface [polypeptide binding]; other site
891974006270	Transcriptional regulator [Transcription]; Region: IclR; COG1414
891974006271	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
891974006272	Bacterial transcriptional regulator; Region: IclR; pfam01614
891974006273	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974006274	homotrimer interaction site [polypeptide binding]; other site
891974006275	putative active site [active]
891974006276	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974006277	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974006278	substrate binding pocket [chemical binding]; other site
891974006279	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974006280	hinge residues; other site
891974006281	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974006282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006283	dimer interface [polypeptide binding]; other site
891974006284	conserved gate region; other site
891974006285	putative PBP binding loops; other site
891974006286	ABC-ATPase subunit interface; other site
891974006287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974006288	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974006289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006290	conserved gate region; other site
891974006291	dimer interface [polypeptide binding]; other site
891974006292	putative PBP binding loops; other site
891974006293	ABC-ATPase subunit interface; other site
891974006294	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
891974006295	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974006296	Walker A/P-loop; other site
891974006297	ATP binding site [chemical binding]; other site
891974006298	Q-loop/lid; other site
891974006299	ABC transporter signature motif; other site
891974006300	Walker B; other site
891974006301	D-loop; other site
891974006302	H-loop/switch region; other site
891974006303	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974006304	catalytic residue [active]
891974006305	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974006306	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
891974006307	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
891974006308	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974006309	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
891974006310	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
891974006311	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
891974006312	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
891974006313	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
891974006314	B12 binding site [chemical binding]; other site
891974006315	cobalt ligand [ion binding]; other site
891974006316	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
891974006317	dimer interface [polypeptide binding]; other site
891974006318	inhibitor binding site; inhibition site
891974006319	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
891974006320	Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105
891974006321	Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105
891974006322	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
891974006323	homoserine O-succinyltransferase; Provisional; Region: PRK05368
891974006324	conserved cys residue [active]
891974006325	protein disaggregation chaperone; Provisional; Region: PRK10865
891974006326	Clp amino terminal domain; Region: Clp_N; pfam02861
891974006327	Clp amino terminal domain; Region: Clp_N; pfam02861
891974006328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974006329	Walker A motif; other site
891974006330	ATP binding site [chemical binding]; other site
891974006331	Walker B motif; other site
891974006332	arginine finger; other site
891974006333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974006334	Walker A motif; other site
891974006335	ATP binding site [chemical binding]; other site
891974006336	Walker B motif; other site
891974006337	arginine finger; other site
891974006338	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
891974006339	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
891974006340	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
891974006341	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974006342	RNA binding surface [nucleotide binding]; other site
891974006343	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
891974006344	active site
891974006345	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
891974006346	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
891974006347	30S subunit binding site; other site
891974006348	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
891974006349	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
891974006350	Prephenate dehydratase; Region: PDT; pfam00800
891974006351	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
891974006352	putative L-Phe binding site [chemical binding]; other site
891974006353	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
891974006354	Chorismate mutase type II; Region: CM_2; cl00693
891974006355	prephenate dehydrogenase; Validated; Region: PRK08507
891974006356	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
891974006357	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974006358	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
891974006359	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
891974006360	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
891974006361	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
891974006362	RimM N-terminal domain; Region: RimM; pfam01782
891974006363	PRC-barrel domain; Region: PRC; pfam05239
891974006364	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
891974006365	signal recognition particle protein; Provisional; Region: PRK10867
891974006366	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
891974006367	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
891974006368	P loop; other site
891974006369	GTP binding site [chemical binding]; other site
891974006370	Signal peptide binding domain; Region: SRP_SPB; pfam02978
891974006371	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
891974006372	Domain of unknown function DUF21; Region: DUF21; pfam01595
891974006373	hypothetical protein; Provisional; Region: PRK11573
891974006374	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
891974006375	Transporter associated domain; Region: CorC_HlyC; smart01091
891974006376	S-ribosylhomocysteinase; Provisional; Region: PRK02260
891974006377	glutamate--cysteine ligase; Provisional; Region: PRK02107
891974006378	Predicted membrane protein [Function unknown]; Region: COG1238
891974006379	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
891974006380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974006381	active site
891974006382	motif I; other site
891974006383	motif II; other site
891974006384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974006385	Transposase; Region: HTH_Tnp_1; cl17663
891974006386	Integrase core domain; Region: rve; pfam00665
891974006387	Integrase core domain; Region: rve_3; pfam13683
891974006388	AAA domain; Region: AAA_17; cl19128
891974006389	AAA domain; Region: AAA_33; pfam13671
891974006390	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
891974006391	active site
891974006392	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
891974006393	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974006394	Transposase; Region: HTH_Tnp_1; cl17663
891974006395	Integrase core domain; Region: rve; pfam00665
891974006396	Integrase core domain; Region: rve_3; pfam13683
891974006397	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
891974006398	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
891974006399	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
891974006400	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
891974006401	nucleotide binding pocket [chemical binding]; other site
891974006402	K-X-D-G motif; other site
891974006403	catalytic site [active]
891974006404	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
891974006405	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
891974006406	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
891974006407	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
891974006408	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
891974006409	Dimer interface [polypeptide binding]; other site
891974006410	BRCT sequence motif; other site
891974006411	cell division protein ZipA; Provisional; Region: PRK03427
891974006412	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
891974006413	FtsZ protein binding site [polypeptide binding]; other site
891974006414	putative sulfate transport protein CysZ; Validated; Region: PRK04949
891974006415	cysteine synthase; Region: PLN02565
891974006416	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
891974006417	dimer interface [polypeptide binding]; other site
891974006418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974006419	catalytic residue [active]
891974006420	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
891974006421	dimerization domain swap beta strand [polypeptide binding]; other site
891974006422	regulatory protein interface [polypeptide binding]; other site
891974006423	active site
891974006424	regulatory phosphorylation site [posttranslational modification]; other site
891974006425	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
891974006426	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
891974006427	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
891974006428	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
891974006429	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
891974006430	HPr interaction site; other site
891974006431	glycerol kinase (GK) interaction site [polypeptide binding]; other site
891974006432	active site
891974006433	phosphorylation site [posttranslational modification]
891974006434	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974006435	dimerization interface [polypeptide binding]; other site
891974006436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974006437	dimer interface [polypeptide binding]; other site
891974006438	phosphorylation site [posttranslational modification]
891974006439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974006440	ATP binding site [chemical binding]; other site
891974006441	Mg2+ binding site [ion binding]; other site
891974006442	G-X-G motif; other site
891974006443	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
891974006444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974006445	active site
891974006446	phosphorylation site [posttranslational modification]
891974006447	intermolecular recognition site; other site
891974006448	dimerization interface [polypeptide binding]; other site
891974006449	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974006450	DNA binding site [nucleotide binding]
891974006451	cheY-homologous receiver domain; Region: REC; smart00448
891974006452	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
891974006453	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
891974006454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974006455	dimer interface [polypeptide binding]; other site
891974006456	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974006457	catalytic residue [active]
891974006458	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
891974006459	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
891974006460	Walker A/P-loop; other site
891974006461	ATP binding site [chemical binding]; other site
891974006462	Q-loop/lid; other site
891974006463	ABC transporter signature motif; other site
891974006464	Walker B; other site
891974006465	D-loop; other site
891974006466	H-loop/switch region; other site
891974006467	TOBE-like domain; Region: TOBE_3; pfam12857
891974006468	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
891974006469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006470	dimer interface [polypeptide binding]; other site
891974006471	conserved gate region; other site
891974006472	putative PBP binding loops; other site
891974006473	ABC-ATPase subunit interface; other site
891974006474	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
891974006475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006476	dimer interface [polypeptide binding]; other site
891974006477	conserved gate region; other site
891974006478	putative PBP binding loops; other site
891974006479	ABC-ATPase subunit interface; other site
891974006480	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974006481	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974006482	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
891974006483	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
891974006484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974006485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974006486	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
891974006487	active site
891974006488	metal binding site [ion binding]; metal-binding site
891974006489	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
891974006490	active site
891974006491	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
891974006492	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
891974006493	Malic enzyme, N-terminal domain; Region: malic; pfam00390
891974006494	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
891974006495	putative NAD(P) binding site [chemical binding]; other site
891974006496	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
891974006497	transaldolase-like protein; Provisional; Region: PTZ00411
891974006498	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
891974006499	active site
891974006500	dimer interface [polypeptide binding]; other site
891974006501	catalytic residue [active]
891974006502	transketolase; Reviewed; Region: PRK12753
891974006503	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
891974006504	TPP-binding site [chemical binding]; other site
891974006505	dimer interface [polypeptide binding]; other site
891974006506	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
891974006507	PYR/PP interface [polypeptide binding]; other site
891974006508	dimer interface [polypeptide binding]; other site
891974006509	TPP binding site [chemical binding]; other site
891974006510	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
891974006511	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
891974006512	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
891974006513	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
891974006514	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974006515	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
891974006516	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
891974006517	ligand binding site [chemical binding]; other site
891974006518	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
891974006519	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974006520	Walker A/P-loop; other site
891974006521	ATP binding site [chemical binding]; other site
891974006522	Q-loop/lid; other site
891974006523	ABC transporter signature motif; other site
891974006524	Walker B; other site
891974006525	D-loop; other site
891974006526	H-loop/switch region; other site
891974006527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006528	Walker A/P-loop; other site
891974006529	ATP binding site [chemical binding]; other site
891974006530	Q-loop/lid; other site
891974006531	ABC transporter signature motif; other site
891974006532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006533	H-loop/switch region; other site
891974006534	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
891974006535	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974006536	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974006537	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974006538	TM-ABC transporter signature motif; other site
891974006539	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
891974006540	metal binding site [ion binding]; metal-binding site
891974006541	substrate binding site [chemical binding]; other site
891974006542	hexamer interface [polypeptide binding]; other site
891974006543	D-allose kinase; Provisional; Region: PRK09698
891974006544	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974006545	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974006546	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
891974006547	dimer interface [polypeptide binding]; other site
891974006548	ADP-ribose binding site [chemical binding]; other site
891974006549	active site
891974006550	nudix motif; other site
891974006551	metal binding site [ion binding]; metal-binding site
891974006552	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
891974006553	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
891974006554	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
891974006555	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
891974006556	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
891974006557	molybdopterin cofactor binding site; other site
891974006558	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
891974006559	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
891974006560	NapD protein; Region: NapD; cl01163
891974006561	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
891974006562	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
891974006563	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
891974006564	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
891974006565	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974006566	dimerization interface [polypeptide binding]; other site
891974006567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
891974006568	Histidine kinase; Region: HisKA_3; pfam07730
891974006569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974006570	ATP binding site [chemical binding]; other site
891974006571	Mg2+ binding site [ion binding]; other site
891974006572	G-X-G motif; other site
891974006573	transcriptional regulator NarP; Provisional; Region: PRK10403
891974006574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974006575	active site
891974006576	phosphorylation site [posttranslational modification]
891974006577	intermolecular recognition site; other site
891974006578	dimerization interface [polypeptide binding]; other site
891974006579	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974006580	DNA binding residues [nucleotide binding]
891974006581	dimerization interface [polypeptide binding]; other site
891974006582	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
891974006583	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
891974006584	MMPL family; Region: MMPL; cl14618
891974006585	Fruit fly transformer protein; Region: Transformer; pfam06495
891974006586	MMPL family; Region: MMPL; cl14618
891974006587	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
891974006588	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
891974006589	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
891974006590	metal binding site [ion binding]; metal-binding site
891974006591	dimer interface [polypeptide binding]; other site
891974006592	hypothetical protein; Provisional; Region: PRK13664
891974006593	putative hydrolase; Provisional; Region: PRK11460
891974006594	putative hydrolase; Provisional; Region: PRK11460
891974006595	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
891974006596	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
891974006597	Helicase; Region: Helicase_RecD; pfam05127
891974006598	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
891974006599	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
891974006600	Predicted metalloprotease [General function prediction only]; Region: COG2321
891974006601	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825
891974006602	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
891974006603	ATP binding site [chemical binding]; other site
891974006604	active site
891974006605	substrate binding site [chemical binding]; other site
891974006606	lipoprotein; Provisional; Region: PRK11679
891974006607	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
891974006608	dimer interface [polypeptide binding]; other site
891974006609	active site
891974006610	catalytic residue [active]
891974006611	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
891974006612	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
891974006613	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
891974006614	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
891974006615	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
891974006616	catalytic triad [active]
891974006617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974006618	metal binding site [ion binding]; metal-binding site
891974006619	active site
891974006620	I-site; other site
891974006621	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974006622	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
891974006623	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
891974006624	active site
891974006625	metal binding site [ion binding]; metal-binding site
891974006626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006627	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
891974006628	Walker A/P-loop; other site
891974006629	ATP binding site [chemical binding]; other site
891974006630	Q-loop/lid; other site
891974006631	ABC transporter signature motif; other site
891974006632	Walker B; other site
891974006633	D-loop; other site
891974006634	H-loop/switch region; other site
891974006635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006636	dimer interface [polypeptide binding]; other site
891974006637	conserved gate region; other site
891974006638	putative PBP binding loops; other site
891974006639	ABC-ATPase subunit interface; other site
891974006640	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
891974006641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006642	dimer interface [polypeptide binding]; other site
891974006643	conserved gate region; other site
891974006644	putative PBP binding loops; other site
891974006645	ABC-ATPase subunit interface; other site
891974006646	DsrE/DsrF-like family; Region: DrsE; pfam02635
891974006647	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
891974006648	Peptidase family M48; Region: Peptidase_M48; cl12018
891974006649	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
891974006650	catalytic residues [active]
891974006651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
891974006652	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
891974006653	uracil transporter; Provisional; Region: PRK10720
891974006654	uracil-xanthine permease; Region: ncs2; TIGR00801
891974006655	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974006656	active site
891974006657	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
891974006658	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
891974006659	dimerization interface [polypeptide binding]; other site
891974006660	putative ATP binding site [chemical binding]; other site
891974006661	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
891974006662	active site
891974006663	substrate binding site [chemical binding]; other site
891974006664	cosubstrate binding site; other site
891974006665	catalytic site [active]
891974006666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006667	H-loop/switch region; other site
891974006668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006669	ABC transporter signature motif; other site
891974006670	Walker B; other site
891974006671	D-loop; other site
891974006672	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006673	Walker A/P-loop; other site
891974006674	ATP binding site [chemical binding]; other site
891974006675	Q-loop/lid; other site
891974006676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006677	ABC-ATPase subunit interface; other site
891974006678	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
891974006679	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
891974006680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974006681	conserved gate region; other site
891974006682	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
891974006683	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
891974006684	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
891974006685	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
891974006686	domain interface [polypeptide binding]; other site
891974006687	active site
891974006688	catalytic site [active]
891974006689	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
891974006690	domain interface [polypeptide binding]; other site
891974006691	active site
891974006692	catalytic site [active]
891974006693	exopolyphosphatase; Provisional; Region: PRK10854
891974006694	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974006695	nucleotide binding site [chemical binding]; other site
891974006696	tellurite resistance protein TehB; Provisional; Region: PRK11207
891974006697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974006698	S-adenosylmethionine binding site [chemical binding]; other site
891974006699	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
891974006700	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
891974006701	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
891974006702	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
891974006703	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
891974006704	Divalent cation transporter; Region: MgtE; cl00786
891974006705	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
891974006706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974006707	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
891974006708	NAD(P) binding site [chemical binding]; other site
891974006709	active site
891974006710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974006711	putative transporter; Provisional; Region: PRK12382
891974006712	hypothetical protein; Provisional; Region: PRK08204
891974006713	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974006714	active site
891974006715	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974006716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974006717	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974006718	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974006719	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974006720	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
891974006721	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
891974006722	putative NAD(P) binding site [chemical binding]; other site
891974006723	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
891974006724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974006725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974006726	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
891974006727	substrate binding pocket [chemical binding]; other site
891974006728	dimerization interface [polypeptide binding]; other site
891974006729	GMP synthase; Reviewed; Region: guaA; PRK00074
891974006730	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
891974006731	AMP/PPi binding site [chemical binding]; other site
891974006732	candidate oxyanion hole; other site
891974006733	catalytic triad [active]
891974006734	potential glutamine specificity residues [chemical binding]; other site
891974006735	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
891974006736	ATP Binding subdomain [chemical binding]; other site
891974006737	Ligand Binding sites [chemical binding]; other site
891974006738	Dimerization subdomain; other site
891974006739	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
891974006740	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
891974006741	active site
891974006742	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
891974006743	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
891974006744	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
891974006745	generic binding surface II; other site
891974006746	generic binding surface I; other site
891974006747	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
891974006748	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
891974006749	active site
891974006750	Zn binding site [ion binding]; other site
891974006751	General stress protein [General function prediction only]; Region: GsiB; COG3729
891974006752	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
891974006753	active site
891974006754	Trp docking motif [polypeptide binding]; other site
891974006755	Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993
891974006756	GTP-binding protein Der; Reviewed; Region: PRK00093
891974006757	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
891974006758	G1 box; other site
891974006759	GTP/Mg2+ binding site [chemical binding]; other site
891974006760	Switch I region; other site
891974006761	G2 box; other site
891974006762	Switch II region; other site
891974006763	G3 box; other site
891974006764	G4 box; other site
891974006765	G5 box; other site
891974006766	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
891974006767	G1 box; other site
891974006768	GTP/Mg2+ binding site [chemical binding]; other site
891974006769	Switch I region; other site
891974006770	G2 box; other site
891974006771	G3 box; other site
891974006772	Switch II region; other site
891974006773	G4 box; other site
891974006774	G5 box; other site
891974006775	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
891974006776	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
891974006777	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
891974006778	Trp docking motif [polypeptide binding]; other site
891974006779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
891974006780	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
891974006781	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
891974006782	dimer interface [polypeptide binding]; other site
891974006783	motif 1; other site
891974006784	active site
891974006785	motif 2; other site
891974006786	motif 3; other site
891974006787	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
891974006788	anticodon binding site; other site
891974006789	GcpE protein; Region: GcpE; cl19500
891974006790	GcpE protein; Region: GcpE; cl19500
891974006791	cytoskeletal protein RodZ; Provisional; Region: PRK10856
891974006792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974006793	non-specific DNA binding site [nucleotide binding]; other site
891974006794	salt bridge; other site
891974006795	sequence-specific DNA binding site [nucleotide binding]; other site
891974006796	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
891974006797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
891974006798	binding surface
891974006799	TPR motif; other site
891974006800	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
891974006801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974006802	FeS/SAM binding site; other site
891974006803	Nucleoside diphosphate kinase; Region: NDK; pfam00334
891974006804	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
891974006805	active site
891974006806	multimer interface [polypeptide binding]; other site
891974006807	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974006808	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
891974006809	Transglycosylase; Region: Transgly; pfam00912
891974006810	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
891974006811	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
891974006812	surface patch; other site
891974006813	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
891974006814	MG2 domain; Region: A2M_N; cl19929
891974006815	Bacterial Ig-like domain; Region: Big_5; pfam13205
891974006816	MG2 domain; Region: A2M_N; pfam01835
891974006817	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
891974006818	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
891974006819	active site residue [active]
891974006820	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
891974006821	active site residue [active]
891974006822	SseB protein N-terminal domain; Region: SseB; pfam07179
891974006823	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
891974006824	SseB protein C-terminal domain; Region: SseB_C; pfam14581
891974006825	Cytosol aminopeptidase family, catalytic domain; Region: Peptidase_M17; pfam00883
891974006826	Cytosol aminopeptidase family, catalytic domain; Region: Peptidase_M17; pfam00883
891974006827	Peptidase; Region: DUF3663; pfam12404
891974006828	cysteine desulfurase; Provisional; Region: PRK14012
891974006829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974006830	catalytic residue [active]
891974006831	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
891974006832	Rrf2 family protein; Region: rrf2_super; TIGR00738
891974006833	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
891974006834	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
891974006835	active site
891974006836	dimerization interface [polypeptide binding]; other site
891974006837	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
891974006838	Laminin Domain I; Region: Laminin_I; pfam06008
891974006839	High-affinity nickel-transport protein; Region: NicO; cl00964
891974006840	High-affinity nickel-transport protein; Region: NicO; cl00964
891974006841	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
891974006842	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
891974006843	PRD domain; Region: PRD; pfam00874
891974006844	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974006845	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974006846	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974006847	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
891974006848	dimer interface [polypeptide binding]; other site
891974006849	active site
891974006850	glycine-pyridoxal phosphate binding site [chemical binding]; other site
891974006851	folate binding site [chemical binding]; other site
891974006852	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
891974006853	heme-binding site [chemical binding]; other site
891974006854	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
891974006855	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
891974006856	FAD binding pocket [chemical binding]; other site
891974006857	FAD binding motif [chemical binding]; other site
891974006858	phosphate binding motif [ion binding]; other site
891974006859	beta-alpha-beta structure motif; other site
891974006860	NAD binding pocket [chemical binding]; other site
891974006861	Heme binding  pocket [chemical binding]; other site
891974006862	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
891974006863	response regulator GlrR; Provisional; Region: PRK15115
891974006864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974006865	active site
891974006866	phosphorylation site [posttranslational modification]
891974006867	intermolecular recognition site; other site
891974006868	dimerization interface [polypeptide binding]; other site
891974006869	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974006870	Walker A motif; other site
891974006871	ATP binding site [chemical binding]; other site
891974006872	Walker B motif; other site
891974006873	arginine finger; other site
891974006874	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
891974006875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
891974006876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974006877	dimer interface [polypeptide binding]; other site
891974006878	phosphorylation site [posttranslational modification]
891974006879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974006880	ATP binding site [chemical binding]; other site
891974006881	Mg2+ binding site [ion binding]; other site
891974006882	G-X-G motif; other site
891974006883	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
891974006884	putative active site [active]
891974006885	catalytic triad [active]
891974006886	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
891974006887	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
891974006888	dimerization interface [polypeptide binding]; other site
891974006889	ATP binding site [chemical binding]; other site
891974006890	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
891974006891	dimerization interface [polypeptide binding]; other site
891974006892	ATP binding site [chemical binding]; other site
891974006893	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
891974006894	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974006895	substrate binding pocket [chemical binding]; other site
891974006896	membrane-bound complex binding site; other site
891974006897	hinge residues; other site
891974006898	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974006899	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974006900	catalytic residue [active]
891974006901	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
891974006902	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
891974006903	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
891974006904	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
891974006905	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
891974006906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974006907	Walker A/P-loop; other site
891974006908	ATP binding site [chemical binding]; other site
891974006909	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
891974006910	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974006911	DNA binding site [nucleotide binding]
891974006912	active site
891974006913	Int/Topo IB signature motif; other site
891974006914	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
891974006915	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
891974006916	SmpB-tmRNA interface; other site
891974006917	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
891974006918	putative coenzyme Q binding site [chemical binding]; other site
891974006919	hypothetical protein; Validated; Region: PRK01777
891974006920	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
891974006921	recombination and repair protein; Provisional; Region: PRK10869
891974006922	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
891974006923	Walker A/P-loop; other site
891974006924	ATP binding site [chemical binding]; other site
891974006925	Q-loop/lid; other site
891974006926	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
891974006927	Q-loop/lid; other site
891974006928	ABC transporter signature motif; other site
891974006929	Walker B; other site
891974006930	D-loop; other site
891974006931	H-loop/switch region; other site
891974006932	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
891974006933	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
891974006934	dimer interface [polypeptide binding]; other site
891974006935	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
891974006936	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
891974006937	ligand binding site [chemical binding]; other site
891974006938	active site
891974006939	UGI interface [polypeptide binding]; other site
891974006940	catalytic site [active]
891974006941	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
891974006942	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
891974006943	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
891974006944	ATP binding site [chemical binding]; other site
891974006945	Mg++ binding site [ion binding]; other site
891974006946	motif III; other site
891974006947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974006948	nucleotide binding region [chemical binding]; other site
891974006949	ATP-binding site [chemical binding]; other site
891974006950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974006951	S-adenosylmethionine binding site [chemical binding]; other site
891974006952	L-aspartate oxidase; Provisional; Region: PRK09077
891974006953	L-aspartate oxidase; Provisional; Region: PRK06175
891974006954	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
891974006955	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
891974006956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
891974006957	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
891974006958	DNA binding residues [nucleotide binding]
891974006959	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
891974006960	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
891974006961	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
891974006962	anti-sigma E factor; Provisional; Region: rseB; PRK09455
891974006963	SoxR reducing system protein RseC; Provisional; Region: PRK10862
891974006964	GTP-binding protein LepA; Provisional; Region: PRK05433
891974006965	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
891974006966	G1 box; other site
891974006967	putative GEF interaction site [polypeptide binding]; other site
891974006968	GTP/Mg2+ binding site [chemical binding]; other site
891974006969	Switch I region; other site
891974006970	G2 box; other site
891974006971	G3 box; other site
891974006972	Switch II region; other site
891974006973	G4 box; other site
891974006974	G5 box; other site
891974006975	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
891974006976	Elongation Factor G, domain II; Region: EFG_II; pfam14492
891974006977	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
891974006978	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
891974006979	signal peptidase I; Provisional; Region: PRK10861
891974006980	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
891974006981	Catalytic site [active]
891974006982	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
891974006983	ribonuclease III; Reviewed; Region: rnc; PRK00102
891974006984	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
891974006985	dimerization interface [polypeptide binding]; other site
891974006986	active site
891974006987	metal binding site [ion binding]; metal-binding site
891974006988	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
891974006989	dsRNA binding site [nucleotide binding]; other site
891974006990	GTPase Era; Reviewed; Region: era; PRK00089
891974006991	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
891974006992	G1 box; other site
891974006993	GTP/Mg2+ binding site [chemical binding]; other site
891974006994	Switch I region; other site
891974006995	G2 box; other site
891974006996	Switch II region; other site
891974006997	G3 box; other site
891974006998	G4 box; other site
891974006999	G5 box; other site
891974007000	KH domain; Region: KH_2; pfam07650
891974007001	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
891974007002	Recombination protein O N terminal; Region: RecO_N; pfam11967
891974007003	Recombination protein O C terminal; Region: RecO_C; pfam02565
891974007004	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
891974007005	active site
891974007006	hydrophilic channel; other site
891974007007	dimerization interface [polypeptide binding]; other site
891974007008	catalytic residues [active]
891974007009	active site lid [active]
891974007010	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
891974007011	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
891974007012	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
891974007013	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
891974007014	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
891974007015	Ligand binding site; other site
891974007016	Putative Catalytic site; other site
891974007017	DXD motif; other site
891974007018	GtrA-like protein; Region: GtrA; cl19823
891974007019	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974007020	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
891974007021	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974007022	putative active site [active]
891974007023	hypothetical protein; Provisional; Region: PRK11590
891974007024	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
891974007025	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
891974007026	nucleoside/Zn binding site; other site
891974007027	dimer interface [polypeptide binding]; other site
891974007028	catalytic motif [active]
891974007029	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
891974007030	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
891974007031	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974007032	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974007033	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974007034	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
891974007035	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974007036	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974007037	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974007038	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974007039	inhibitor-cofactor binding pocket; inhibition site
891974007040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974007041	catalytic residue [active]
891974007042	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
891974007043	substrate binding site [chemical binding]; other site
891974007044	hexamer interface [polypeptide binding]; other site
891974007045	metal binding site [ion binding]; metal-binding site
891974007046	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
891974007047	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
891974007048	pore gating glutamate residue; other site
891974007049	glutaminase; Provisional; Region: PRK00971
891974007050	Fic/DOC family; Region: Fic; cl00960
891974007051	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
891974007052	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
891974007053	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
891974007054	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
891974007055	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
891974007056	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
891974007057	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974007058	NAD(P) binding site [chemical binding]; other site
891974007059	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
891974007060	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974007061	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
891974007062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974007063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974007064	active site
891974007065	phosphorylation site [posttranslational modification]
891974007066	intermolecular recognition site; other site
891974007067	dimerization interface [polypeptide binding]; other site
891974007068	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
891974007069	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974007070	Walker A/P-loop; other site
891974007071	ATP binding site [chemical binding]; other site
891974007072	Q-loop/lid; other site
891974007073	H-loop/switch region; other site
891974007074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007075	dimer interface [polypeptide binding]; other site
891974007076	conserved gate region; other site
891974007077	putative PBP binding loops; other site
891974007078	ABC-ATPase subunit interface; other site
891974007079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974007080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007081	ABC-ATPase subunit interface; other site
891974007082	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
891974007083	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974007084	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974007085	substrate binding pocket [chemical binding]; other site
891974007086	membrane-bound complex binding site; other site
891974007087	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
891974007088	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974007089	metal binding site [ion binding]; metal-binding site
891974007090	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
891974007091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974007092	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
891974007093	dimerization interface [polypeptide binding]; other site
891974007094	substrate binding pocket [chemical binding]; other site
891974007095	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974007096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974007097	active site
891974007098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974007099	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974007100	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
891974007101	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
891974007102	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974007103	NAD(P) binding site [chemical binding]; other site
891974007104	active site
891974007105	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
891974007106	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
891974007107	oligomer interface [polypeptide binding]; other site
891974007108	putative Cl binding site [ion binding]; other site
891974007109	basic sphincter; other site
891974007110	hydrophobic gate; other site
891974007111	periplasmic entrance; other site
891974007112	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
891974007113	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974007114	dimer interface [polypeptide binding]; other site
891974007115	putative CheW interface [polypeptide binding]; other site
891974007116	EamA-like transporter family; Region: EamA; pfam00892
891974007117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974007118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007119	putative substrate translocation pore; other site
891974007120	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974007121	EthD domain; Region: EthD; cl17553
891974007122	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
891974007123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974007124	NAD(P) binding site [chemical binding]; other site
891974007125	active site
891974007126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974007127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974007128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974007129	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
891974007130	Walker A/P-loop; other site
891974007131	ATP binding site [chemical binding]; other site
891974007132	Q-loop/lid; other site
891974007133	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
891974007134	glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494
891974007135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007136	dimer interface [polypeptide binding]; other site
891974007137	conserved gate region; other site
891974007138	putative PBP binding loops; other site
891974007139	ABC-ATPase subunit interface; other site
891974007140	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
891974007141	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974007142	substrate binding pocket [chemical binding]; other site
891974007143	membrane-bound complex binding site; other site
891974007144	hinge residues; other site
891974007145	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974007146	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974007147	inhibitor-cofactor binding pocket; inhibition site
891974007148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974007149	catalytic residue [active]
891974007150	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974007151	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974007152	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974007153	putative active site [active]
891974007154	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
891974007155	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
891974007156	dimerization interface [polypeptide binding]; other site
891974007157	substrate binding pocket [chemical binding]; other site
891974007158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974007159	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
891974007160	active site
891974007161	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974007162	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
891974007163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974007164	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
891974007165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974007166	Coenzyme A binding pocket [chemical binding]; other site
891974007167	Uncharacterized conserved protein [Function unknown]; Region: COG3791
891974007168	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
891974007169	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974007170	active site
891974007171	metal binding site [ion binding]; metal-binding site
891974007172	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
891974007173	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974007174	DNA-binding site [nucleotide binding]; DNA binding site
891974007175	UTRA domain; Region: UTRA; pfam07702
891974007176	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007177	substrate binding site [chemical binding]; other site
891974007178	ATP binding site [chemical binding]; other site
891974007179	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
891974007180	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974007181	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
891974007182	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
891974007183	G1 box; other site
891974007184	putative GEF interaction site [polypeptide binding]; other site
891974007185	GTP/Mg2+ binding site [chemical binding]; other site
891974007186	Switch I region; other site
891974007187	G2 box; other site
891974007188	G3 box; other site
891974007189	Switch II region; other site
891974007190	G4 box; other site
891974007191	G5 box; other site
891974007192	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
891974007193	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
891974007194	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
891974007195	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
891974007196	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
891974007197	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
891974007198	DALR anticodon binding domain; Region: DALR_1; pfam05746
891974007199	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
891974007200	dimer interface [polypeptide binding]; other site
891974007201	motif 1; other site
891974007202	active site
891974007203	motif 2; other site
891974007204	motif 3; other site
891974007205	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
891974007206	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
891974007207	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
891974007208	conserved cys residue [active]
891974007209	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974007210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974007211	xylulokinase; Provisional; Region: PRK15027
891974007212	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
891974007213	N- and C-terminal domain interface [polypeptide binding]; other site
891974007214	active site
891974007215	MgATP binding site [chemical binding]; other site
891974007216	catalytic site [active]
891974007217	metal binding site [ion binding]; metal-binding site
891974007218	xylulose binding site [chemical binding]; other site
891974007219	homodimer interface [polypeptide binding]; other site
891974007220	xylose isomerase; Provisional; Region: PRK05474
891974007221	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
891974007222	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
891974007223	putative ligand binding site [chemical binding]; other site
891974007224	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
891974007225	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974007226	Walker A/P-loop; other site
891974007227	ATP binding site [chemical binding]; other site
891974007228	Q-loop/lid; other site
891974007229	ABC transporter signature motif; other site
891974007230	Walker B; other site
891974007231	D-loop; other site
891974007232	H-loop/switch region; other site
891974007233	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
891974007234	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974007235	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974007236	TM-ABC transporter signature motif; other site
891974007237	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007238	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
891974007239	Transcriptional regulator; Region: Rrf2; pfam02082
891974007240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974007241	active site
891974007242	phosphorylation site [posttranslational modification]
891974007243	intermolecular recognition site; other site
891974007244	dimerization interface [polypeptide binding]; other site
891974007245	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
891974007246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974007247	dimer interface [polypeptide binding]; other site
891974007248	phosphorylation site [posttranslational modification]
891974007249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974007250	ATP binding site [chemical binding]; other site
891974007251	G-X-G motif; other site
891974007252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974007253	active site
891974007254	phosphorylation site [posttranslational modification]
891974007255	intermolecular recognition site; other site
891974007256	dimerization interface [polypeptide binding]; other site
891974007257	Hpt domain; Region: Hpt; pfam01627
891974007258	putative binding surface; other site
891974007259	active site
891974007260	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
891974007261	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
891974007262	EpsG family; Region: EpsG; pfam14897
891974007263	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
891974007264	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
891974007265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007266	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007267	DNA binding site [nucleotide binding]
891974007268	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007269	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974007270	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974007271	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974007272	DNA replication protein DnaC; Validated; Region: PRK07952
891974007273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974007274	Walker A motif; other site
891974007275	ATP binding site [chemical binding]; other site
891974007276	Walker B motif; other site
891974007277	primosomal protein DnaI; Provisional; Region: PRK02854
891974007278	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974007279	ligand binding site [chemical binding]; other site
891974007280	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974007281	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007282	DNA binding site [nucleotide binding]
891974007283	domain linker motif; other site
891974007284	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007285	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974007286	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007287	DNA binding site [nucleotide binding]
891974007288	domain linker motif; other site
891974007289	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007290	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
891974007291	putative deacylase active site [active]
891974007292	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
891974007293	EamA-like transporter family; Region: EamA; pfam00892
891974007294	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
891974007295	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
891974007296	putative dimer interface [polypeptide binding]; other site
891974007297	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
891974007298	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
891974007299	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
891974007300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007302	putative substrate translocation pore; other site
891974007303	galactonate dehydratase; Provisional; Region: PRK14017
891974007304	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
891974007305	putative active site pocket [active]
891974007306	putative metal binding site [ion binding]; other site
891974007307	Class I aldolases; Region: Aldolase_Class_I; cl17187
891974007308	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
891974007309	active site
891974007310	Transcriptional regulators [Transcription]; Region: FadR; COG2186
891974007311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974007312	DNA-binding site [nucleotide binding]; DNA binding site
891974007313	FCD domain; Region: FCD; pfam07729
891974007314	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974007315	sugar phosphate phosphatase; Provisional; Region: PRK10513
891974007316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974007317	active site
891974007318	motif I; other site
891974007319	motif II; other site
891974007320	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
891974007321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974007322	ATP binding site [chemical binding]; other site
891974007323	Mg2+ binding site [ion binding]; other site
891974007324	G-X-G motif; other site
891974007325	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
891974007326	anchoring element; other site
891974007327	dimer interface [polypeptide binding]; other site
891974007328	ATP binding site [chemical binding]; other site
891974007329	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
891974007330	active site
891974007331	putative metal-binding site [ion binding]; other site
891974007332	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
891974007333	recF protein; Region: recf; TIGR00611
891974007334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974007335	Walker A/P-loop; other site
891974007336	ATP binding site [chemical binding]; other site
891974007337	Q-loop/lid; other site
891974007338	ABC transporter signature motif; other site
891974007339	Walker B; other site
891974007340	D-loop; other site
891974007341	H-loop/switch region; other site
891974007342	DNA polymerase III subunit beta; Validated; Region: PRK05643
891974007343	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
891974007344	putative DNA binding surface [nucleotide binding]; other site
891974007345	dimer interface [polypeptide binding]; other site
891974007346	beta-clamp/clamp loader binding surface; other site
891974007347	beta-clamp/translesion DNA polymerase binding surface; other site
891974007348	DnaA N-terminal domain; Region: DnaA_N; pfam11638
891974007349	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
891974007350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974007351	Walker A motif; other site
891974007352	ATP binding site [chemical binding]; other site
891974007353	Walker B motif; other site
891974007354	arginine finger; other site
891974007355	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
891974007356	DnaA box-binding interface [nucleotide binding]; other site
891974007357	ribonuclease P; Reviewed; Region: rnpA; PRK01732
891974007358	membrane protein insertase; Provisional; Region: PRK01318
891974007359	YidC periplasmic domain; Region: YidC_periplas; pfam14849
891974007360	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
891974007361	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
891974007362	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
891974007363	trmE is a tRNA modification GTPase; Region: trmE; cd04164
891974007364	G1 box; other site
891974007365	GTP/Mg2+ binding site [chemical binding]; other site
891974007366	Switch I region; other site
891974007367	G2 box; other site
891974007368	Switch II region; other site
891974007369	G3 box; other site
891974007370	G4 box; other site
891974007371	G5 box; other site
891974007372	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
891974007373	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
891974007374	FMN binding site [chemical binding]; other site
891974007375	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
891974007376	dimer interface [polypeptide binding]; other site
891974007377	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
891974007378	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
891974007379	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
891974007380	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
891974007381	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974007382	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
891974007383	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974007384	active site
891974007385	motif I; other site
891974007386	motif II; other site
891974007387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007389	putative substrate translocation pore; other site
891974007390	PhoU domain; Region: PhoU; pfam01895
891974007391	PhoU domain; Region: PhoU; pfam01895
891974007392	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
891974007393	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
891974007394	Walker A/P-loop; other site
891974007395	ATP binding site [chemical binding]; other site
891974007396	Q-loop/lid; other site
891974007397	ABC transporter signature motif; other site
891974007398	Walker B; other site
891974007399	D-loop; other site
891974007400	H-loop/switch region; other site
891974007401	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
891974007402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007403	dimer interface [polypeptide binding]; other site
891974007404	conserved gate region; other site
891974007405	putative PBP binding loops; other site
891974007406	ABC-ATPase subunit interface; other site
891974007407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974007408	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
891974007409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007410	dimer interface [polypeptide binding]; other site
891974007411	conserved gate region; other site
891974007412	ABC-ATPase subunit interface; other site
891974007413	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974007414	Fimbrial protein; Region: Fimbrial; pfam00419
891974007415	Fimbrial protein; Region: Fimbrial; pfam00419
891974007416	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
891974007417	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
891974007418	glutaminase active site [active]
891974007419	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
891974007420	dimer interface [polypeptide binding]; other site
891974007421	active site
891974007422	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
891974007423	dimer interface [polypeptide binding]; other site
891974007424	active site
891974007425	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
891974007426	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
891974007427	Substrate binding site; other site
891974007428	Mg++ binding site; other site
891974007429	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
891974007430	active site
891974007431	substrate binding site [chemical binding]; other site
891974007432	CoA binding site [chemical binding]; other site
891974007433	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
891974007434	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
891974007435	gamma subunit interface [polypeptide binding]; other site
891974007436	epsilon subunit interface [polypeptide binding]; other site
891974007437	LBP interface [polypeptide binding]; other site
891974007438	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
891974007439	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
891974007440	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
891974007441	alpha subunit interaction interface [polypeptide binding]; other site
891974007442	Walker A motif; other site
891974007443	ATP binding site [chemical binding]; other site
891974007444	Walker B motif; other site
891974007445	inhibitor binding site; inhibition site
891974007446	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
891974007447	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
891974007448	core domain interface [polypeptide binding]; other site
891974007449	delta subunit interface [polypeptide binding]; other site
891974007450	epsilon subunit interface [polypeptide binding]; other site
891974007451	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
891974007452	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
891974007453	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
891974007454	beta subunit interaction interface [polypeptide binding]; other site
891974007455	Walker A motif; other site
891974007456	ATP binding site [chemical binding]; other site
891974007457	Walker B motif; other site
891974007458	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
891974007459	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
891974007460	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
891974007461	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
891974007462	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
891974007463	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
891974007464	ATP synthase I chain; Region: ATP_synt_I; cl09170
891974007465	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
891974007466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974007467	S-adenosylmethionine binding site [chemical binding]; other site
891974007468	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
891974007469	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
891974007470	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
891974007471	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974007472	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
891974007473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974007474	putative DNA binding site [nucleotide binding]; other site
891974007475	putative Zn2+ binding site [ion binding]; other site
891974007476	AsnC family; Region: AsnC_trans_reg; pfam01037
891974007477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974007478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974007479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974007480	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
891974007481	DinB superfamily; Region: DinB_2; pfam12867
891974007482	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
891974007483	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
891974007484	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
891974007485	metal ion-dependent adhesion site (MIDAS); other site
891974007486	regulatory ATPase RavA; Provisional; Region: PRK13531
891974007487	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974007488	Walker A motif; other site
891974007489	ATP binding site [chemical binding]; other site
891974007490	Walker B motif; other site
891974007491	arginine finger; other site
891974007492	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
891974007493	K+ potassium transporter; Region: K_trans; cl15781
891974007494	K+ potassium transporter; Region: K_trans; cl15781
891974007495	K+ potassium transporter; Region: K_trans; cl15781
891974007496	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974007497	TM-ABC transporter signature motif; other site
891974007498	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007499	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007500	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007501	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007502	ATP binding site [chemical binding]; other site
891974007503	substrate binding site [chemical binding]; other site
891974007504	transcriptional repressor RbsR; Provisional; Region: PRK10423
891974007505	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007506	DNA binding site [nucleotide binding]
891974007507	domain linker motif; other site
891974007508	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
891974007509	dimerization interface [polypeptide binding]; other site
891974007510	ligand binding site [chemical binding]; other site
891974007511	putative transporter; Provisional; Region: PRK10504
891974007512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974007513	putative substrate translocation pore; other site
891974007514	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974007515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974007516	H-loop/switch region; other site
891974007517	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
891974007518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974007519	Walker A/P-loop; other site
891974007520	ATP binding site [chemical binding]; other site
891974007521	Q-loop/lid; other site
891974007522	ABC transporter signature motif; other site
891974007523	Walker B; other site
891974007524	D-loop; other site
891974007525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007526	dimer interface [polypeptide binding]; other site
891974007527	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974007528	conserved gate region; other site
891974007529	putative PBP binding loops; other site
891974007530	ABC-ATPase subunit interface; other site
891974007531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974007532	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
891974007533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974007534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974007535	ABC-ATPase subunit interface; other site
891974007536	putative PBP binding loops; other site
891974007537	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974007538	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
891974007539	membrane-bound complex binding site; other site
891974007540	hinge residues; other site
891974007541	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974007542	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974007543	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
891974007544	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
891974007545	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
891974007546	FMN binding site [chemical binding]; other site
891974007547	active site
891974007548	catalytic residues [active]
891974007549	substrate binding site [chemical binding]; other site
891974007550	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
891974007551	active site
891974007552	zinc binding site [ion binding]; other site
891974007553	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
891974007554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974007555	S-adenosylmethionine binding site [chemical binding]; other site
891974007556	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
891974007557	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
891974007558	hypothetical protein; Provisional; Region: PRK10633
891974007559	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
891974007560	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
891974007561	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
891974007562	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
891974007563	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
891974007564	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
891974007565	carboxyltransferase (CT) interaction site; other site
891974007566	biotinylation site [posttranslational modification]; other site
891974007567	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
891974007568	active site
891974007569	trimer interface [polypeptide binding]; other site
891974007570	dimer interface [polypeptide binding]; other site
891974007571	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
891974007572	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
891974007573	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
891974007574	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
891974007575	Moco binding site; other site
891974007576	metal coordination site [ion binding]; other site
891974007577	regulatory protein CsrD; Provisional; Region: PRK11059
891974007578	diguanylate cyclase; Region: GGDEF; smart00267
891974007579	nucleotidyl binding site; other site
891974007580	metal binding site [ion binding]; metal-binding site
891974007581	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974007582	rod shape-determining protein MreB; Provisional; Region: PRK13927
891974007583	MreB and similar proteins; Region: MreB_like; cd10225
891974007584	nucleotide binding site [chemical binding]; other site
891974007585	Mg binding site [ion binding]; other site
891974007586	putative protofilament interaction site [polypeptide binding]; other site
891974007587	RodZ interaction site [polypeptide binding]; other site
891974007588	rod shape-determining protein MreC; Region: MreC; cl19252
891974007589	rod shape-determining protein MreD; Provisional; Region: PRK11060
891974007590	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
891974007591	active site
891974007592	dimer interface [polypeptide binding]; other site
891974007593	ribonuclease G; Provisional; Region: PRK11712
891974007594	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
891974007595	homodimer interface [polypeptide binding]; other site
891974007596	oligonucleotide binding site [chemical binding]; other site
891974007597	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
891974007598	hypothetical protein; Provisional; Region: PRK10899
891974007599	Protein of unknown function; Region: DUF3971; pfam13116
891974007600	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
891974007601	protease TldD; Provisional; Region: tldD; PRK10735
891974007602	transcriptional regulator; Provisional; Region: PRK10632
891974007603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974007604	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
891974007605	putative effector binding pocket; other site
891974007606	dimerization interface [polypeptide binding]; other site
891974007607	efflux system membrane protein; Provisional; Region: PRK11594
891974007608	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
891974007609	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974007610	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974007611	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
891974007612	Fusaric acid resistance protein family; Region: FUSC; pfam04632
891974007613	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
891974007614	tetramerization interface [polypeptide binding]; other site
891974007615	NAD(P) binding site [chemical binding]; other site
891974007616	catalytic residues [active]
891974007617	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
891974007618	RNAase interaction site [polypeptide binding]; other site
891974007619	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974007620	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974007621	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
891974007622	arginine repressor; Provisional; Region: PRK05066
891974007623	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
891974007624	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
891974007625	malate dehydrogenase; Provisional; Region: PRK05086
891974007626	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
891974007627	NAD binding site [chemical binding]; other site
891974007628	dimerization interface [polypeptide binding]; other site
891974007629	Substrate binding site [chemical binding]; other site
891974007630	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
891974007631	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974007632	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
891974007633	putative mechanosensitive channel protein; Provisional; Region: PRK10929
891974007634	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
891974007635	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
891974007636	GTPase/Zn-binding domain interface [polypeptide binding]; other site
891974007637	GTP/Mg2+ binding site [chemical binding]; other site
891974007638	G4 box; other site
891974007639	G5 box; other site
891974007640	G1 box; other site
891974007641	Switch I region; other site
891974007642	G2 box; other site
891974007643	G3 box; other site
891974007644	Switch II region; other site
891974007645	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
891974007646	RNA binding site [nucleotide binding]; other site
891974007647	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
891974007648	catalytic site [active]
891974007649	putative active site [active]
891974007650	putative substrate binding site [chemical binding]; other site
891974007651	dimer interface [polypeptide binding]; other site
891974007652	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
891974007653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974007654	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
891974007655	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
891974007656	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
891974007657	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
891974007658	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007659	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974007660	ATP binding site [chemical binding]; other site
891974007661	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
891974007662	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
891974007663	AMIN domain; Region: AMIN; pfam11741
891974007664	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
891974007665	active site
891974007666	metal binding site [ion binding]; metal-binding site
891974007667	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974007668	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
891974007669	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974007670	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
891974007671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974007672	ATP binding site [chemical binding]; other site
891974007673	Mg2+ binding site [ion binding]; other site
891974007674	G-X-G motif; other site
891974007675	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
891974007676	ATP binding site [chemical binding]; other site
891974007677	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
891974007678	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
891974007679	bacterial Hfq-like; Region: Hfq; cd01716
891974007680	hexamer interface [polypeptide binding]; other site
891974007681	Sm1 motif; other site
891974007682	RNA binding site [nucleotide binding]; other site
891974007683	Sm2 motif; other site
891974007684	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
891974007685	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
891974007686	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
891974007687	G3 box; other site
891974007688	Switch II region; other site
891974007689	GTP/Mg2+ binding site [chemical binding]; other site
891974007690	G4 box; other site
891974007691	G5 box; other site
891974007692	FtsH protease regulator HflK; Provisional; Region: PRK10930
891974007693	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
891974007694	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
891974007695	HflC protein; Region: hflC; TIGR01932
891974007696	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
891974007697	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
891974007698	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
891974007699	GDP-binding site [chemical binding]; other site
891974007700	ACT binding site; other site
891974007701	IMP binding site; other site
891974007702	Transcriptional regulator; Region: Rrf2; cl17282
891974007703	Rrf2 family protein; Region: rrf2_super; TIGR00738
891974007704	exoribonuclease R; Provisional; Region: PRK11642
891974007705	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
891974007706	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
891974007707	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
891974007708	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
891974007709	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
891974007710	RNA binding site [nucleotide binding]; other site
891974007711	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
891974007712	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
891974007713	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
891974007714	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
891974007715	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
891974007716	active site
891974007717	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
891974007718	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
891974007719	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
891974007720	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974007721	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974007722	putative CheW interface [polypeptide binding]; other site
891974007723	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
891974007724	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974007725	dimerization interface [polypeptide binding]; other site
891974007726	esterase; Provisional; Region: PRK10566
891974007727	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
891974007728	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
891974007729	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
891974007730	dimer interface [polypeptide binding]; other site
891974007731	ssDNA binding site [nucleotide binding]; other site
891974007732	tetramer (dimer of dimers) interface [polypeptide binding]; other site
891974007733	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
891974007734	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
891974007735	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
891974007736	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
891974007737	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
891974007738	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
891974007739	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
891974007740	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
891974007741	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
891974007742	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
891974007743	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974007744	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974007745	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
891974007746	metal binding site [ion binding]; metal-binding site
891974007747	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
891974007748	active site
891974007749	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
891974007750	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
891974007751	Transporter associated domain; Region: CorC_HlyC; smart01091
891974007752	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
891974007753	Domain of unknown function DUF21; Region: DUF21; pfam01595
891974007754	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
891974007755	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
891974007756	Surface antigen; Region: Bac_surface_Ag; pfam01103
891974007757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
891974007758	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
891974007759	Family of unknown function (DUF490); Region: DUF490; pfam04357
891974007760	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
891974007761	dimerization interface [polypeptide binding]; other site
891974007762	putative active site pocket [active]
891974007763	putative catalytic residue [active]
891974007764	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
891974007765	dimer interface [polypeptide binding]; other site
891974007766	substrate binding site [chemical binding]; other site
891974007767	metal binding sites [ion binding]; metal-binding site
891974007768	Protein of unknown function (DUF441); Region: DUF441; cl01041
891974007769	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
891974007770	Mor transcription activator family; Region: Mor; pfam08765
891974007771	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974007772	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974007773	AAA domain; Region: AAA_22; pfam13401
891974007774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974007775	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974007776	non-specific DNA binding site [nucleotide binding]; other site
891974007777	salt bridge; other site
891974007778	sequence-specific DNA binding site [nucleotide binding]; other site
891974007779	Integrase core domain; Region: rve; pfam00665
891974007780	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974007781	Transcriptional regulator; Region: Rrf2; cl17282
891974007782	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974007783	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974007784	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974007785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974007786	non-specific DNA binding site [nucleotide binding]; other site
891974007787	salt bridge; other site
891974007788	sequence-specific DNA binding site [nucleotide binding]; other site
891974007789	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
891974007790	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
891974007791	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974007792	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974007793	catalytic residue [active]
891974007794	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974007795	Phage Terminase; Region: Terminase_1; cl19862
891974007796	Phage Terminase; Region: Terminase_1; cl19862
891974007797	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974007798	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974007799	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974007800	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974007801	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974007802	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974007803	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974007804	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974007805	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974007806	catalytic residues [active]
891974007807	catalytic nucleophile [active]
891974007808	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974007809	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974007810	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974007811	Synaptic Site I dimer interface [polypeptide binding]; other site
891974007812	DNA binding site [nucleotide binding]
891974007813	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974007814	DNA-binding interface [nucleotide binding]; DNA binding site
891974007815	Hpt domain; Region: Hpt; pfam01627
891974007816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974007817	active site
891974007818	phosphorylation site [posttranslational modification]
891974007819	intermolecular recognition site; other site
891974007820	dimerization interface [polypeptide binding]; other site
891974007821	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
891974007822	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974007823	substrate binding pocket [chemical binding]; other site
891974007824	membrane-bound complex binding site; other site
891974007825	hinge residues; other site
891974007826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974007827	dimer interface [polypeptide binding]; other site
891974007828	phosphorylation site [posttranslational modification]
891974007829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974007830	Mg2+ binding site [ion binding]; other site
891974007831	G-X-G motif; other site
891974007832	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
891974007833	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
891974007834	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
891974007835	active site
891974007836	P-loop; other site
891974007837	phosphorylation site [posttranslational modification]
891974007838	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
891974007839	active site
891974007840	phosphorylation site [posttranslational modification]
891974007841	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974007842	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007843	DNA binding site [nucleotide binding]
891974007844	domain linker motif; other site
891974007845	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974007846	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007847	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974007848	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974007849	superoxide dismutase; Provisional; Region: PRK10925
891974007850	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
891974007851	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
891974007852	Protein of unknown function (DUF535); Region: DUF535; pfam04393
891974007853	hypothetical protein; Provisional; Region: PRK11020
891974007854	Protein of unknown function (DUF2810); Region: DUF2810; cl08159
891974007855	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
891974007856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974007857	Walker A motif; other site
891974007858	ATP binding site [chemical binding]; other site
891974007859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974007860	Walker B motif; other site
891974007861	arginine finger; other site
891974007862	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
891974007863	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
891974007864	active site
891974007865	HslU subunit interaction site [polypeptide binding]; other site
891974007866	cell division protein FtsN; Provisional; Region: PRK12757
891974007867	Sporulation related domain; Region: SPOR; pfam05036
891974007868	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974007869	DNA binding site [nucleotide binding]
891974007870	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
891974007871	domain linker motif; other site
891974007872	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
891974007873	dimerization interface [polypeptide binding]; other site
891974007874	ligand binding site [chemical binding]; other site
891974007875	primosome assembly protein PriA; Validated; Region: PRK05580
891974007876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974007877	ATP binding site [chemical binding]; other site
891974007878	putative Mg++ binding site [ion binding]; other site
891974007879	helicase superfamily c-terminal domain; Region: HELICc; smart00490
891974007880	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
891974007881	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
891974007882	dimerization interface [polypeptide binding]; other site
891974007883	DNA binding site [nucleotide binding]
891974007884	corepressor binding sites; other site
891974007885	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
891974007886	homodimer interface [polypeptide binding]; other site
891974007887	substrate-cofactor binding pocket; other site
891974007888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974007889	catalytic residue [active]
891974007890	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
891974007891	substrate binding site [chemical binding]; other site
891974007892	nucleotide binding site [chemical binding]; other site
891974007893	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
891974007894	nucleotide binding site [chemical binding]; other site
891974007895	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
891974007896	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
891974007897	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
891974007898	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
891974007899	Integrase core domain; Region: rve; pfam00665
891974007900	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
891974007901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
891974007902	AAA domain; Region: AAA_22; pfam13401
891974007903	Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077
891974007904	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
891974007905	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
891974007906	metal binding site [ion binding]; metal-binding site
891974007907	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974007908	Mor transcription activator family; Region: Mor; cl02360
891974007909	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
891974007910	catalytic residues [active]
891974007911	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
891974007912	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
891974007913	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
891974007914	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
891974007915	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974007916	Phage Terminase; Region: Terminase_1; cl19862
891974007917	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
891974007918	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
891974007919	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
891974007920	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974007921	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
891974007922	Mu-like prophage I protein; Region: Mu-like_Pro; cl19864
891974007923	Mu-like prophage I protein; Region: Mu-like_Pro; cl19864
891974007924	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
891974007925	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974007926	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974007927	catalytic residues [active]
891974007928	catalytic nucleophile [active]
891974007929	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974007930	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974007931	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974007932	Synaptic Site I dimer interface [polypeptide binding]; other site
891974007933	DNA binding site [nucleotide binding]
891974007934	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974007935	DNA-binding interface [nucleotide binding]; DNA binding site
891974007936	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974007937	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974007938	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974007939	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974007940	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974007941	catalytic residues [active]
891974007942	catalytic nucleophile [active]
891974007943	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974007944	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974007945	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974007946	Synaptic Site I dimer interface [polypeptide binding]; other site
891974007947	DNA binding site [nucleotide binding]
891974007948	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974007949	DNA-binding interface [nucleotide binding]; DNA binding site
891974007950	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
891974007951	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
891974007952	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
891974007953	FAD binding site [chemical binding]; other site
891974007954	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
891974007955	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
891974007956	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
891974007957	metal binding site [ion binding]; metal-binding site
891974007958	putative dimer interface [polypeptide binding]; other site
891974007959	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
891974007960	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
891974007961	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
891974007962	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
891974007963	nucleotide binding site [chemical binding]; other site
891974007964	substrate binding site [chemical binding]; other site
891974007965	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
891974007966	ANP binding site [chemical binding]; other site
891974007967	Substrate Binding Site II [chemical binding]; other site
891974007968	Substrate Binding Site I [chemical binding]; other site
891974007969	argininosuccinate lyase; Provisional; Region: PRK04833
891974007970	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
891974007971	active sites [active]
891974007972	tetramer interface [polypeptide binding]; other site
891974007973	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
891974007974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974007975	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
891974007976	dimerization interface [polypeptide binding]; other site
891974007977	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
891974007978	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974007979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974007980	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
891974007981	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
891974007982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974007983	hypothetical protein; Provisional; Region: PRK11056
891974007984	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
891974007985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974007986	S-adenosylmethionine binding site [chemical binding]; other site
891974007987	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974007988	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974007989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974007990	Transposase; Region: HTH_Tnp_1; cl17663
891974007991	Integrase core domain; Region: rve; pfam00665
891974007992	Integrase core domain; Region: rve_3; pfam13683
891974007993	division inhibitor protein; Provisional; Region: slmA; PRK09480
891974007994	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974007995	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
891974007996	trimer interface [polypeptide binding]; other site
891974007997	active site
891974007998	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
891974007999	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
891974008000	Flavoprotein; Region: Flavoprotein; cl19190
891974008001	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
891974008002	hypothetical protein; Reviewed; Region: PRK00024
891974008003	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
891974008004	RadC-like JAB domain; Region: RadC; pfam04002
891974008005	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
891974008006	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
891974008007	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
891974008008	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
891974008009	DNA binding site [nucleotide binding]
891974008010	catalytic residue [active]
891974008011	H2TH interface [polypeptide binding]; other site
891974008012	putative catalytic residues [active]
891974008013	turnover-facilitating residue; other site
891974008014	intercalation triad [nucleotide binding]; other site
891974008015	8OG recognition residue [nucleotide binding]; other site
891974008016	putative reading head residues; other site
891974008017	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
891974008018	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
891974008019	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
891974008020	active site
891974008021	(T/H)XGH motif; other site
891974008022	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
891974008023	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
891974008024	putative metal binding site; other site
891974008025	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
891974008026	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
891974008027	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
891974008028	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
891974008029	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
891974008030	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
891974008031	putative active site [active]
891974008032	putative glycosyl transferase; Provisional; Region: PRK10073
891974008033	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974008034	active site
891974008035	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974008036	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974008037	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
891974008038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
891974008039	putative ADP-binding pocket [chemical binding]; other site
891974008040	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
891974008041	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
891974008042	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
891974008043	putative active site [active]
891974008044	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
891974008045	putative active site [active]
891974008046	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
891974008047	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
891974008048	NADP binding site [chemical binding]; other site
891974008049	homopentamer interface [polypeptide binding]; other site
891974008050	substrate binding site [chemical binding]; other site
891974008051	active site
891974008052	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974008053	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974008054	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974008055	catalytic residue [active]
891974008056	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
891974008057	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974008058	NAD(P) binding site [chemical binding]; other site
891974008059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
891974008060	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
891974008061	putative ADP-binding pocket [chemical binding]; other site
891974008062	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
891974008063	NodB motif; other site
891974008064	putative active site [active]
891974008065	putative catalytic site [active]
891974008066	Zn binding site [ion binding]; other site
891974008067	AmiB activator; Provisional; Region: PRK11637
891974008068	Peptidase family M23; Region: Peptidase_M23; pfam01551
891974008069	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
891974008070	active site residue [active]
891974008071	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
891974008072	GSH binding site [chemical binding]; other site
891974008073	catalytic residues [active]
891974008074	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
891974008075	SecA binding site; other site
891974008076	Preprotein binding site; other site
891974008077	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
891974008078	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
891974008079	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
891974008080	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
891974008081	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
891974008082	trimer interface [polypeptide binding]; other site
891974008083	active site
891974008084	substrate binding site [chemical binding]; other site
891974008085	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
891974008086	two-component sensor protein; Provisional; Region: cpxA; PRK09470
891974008087	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974008088	dimerization interface [polypeptide binding]; other site
891974008089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974008090	dimer interface [polypeptide binding]; other site
891974008091	phosphorylation site [posttranslational modification]
891974008092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974008093	ATP binding site [chemical binding]; other site
891974008094	Mg2+ binding site [ion binding]; other site
891974008095	G-X-G motif; other site
891974008096	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
891974008097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974008098	active site
891974008099	phosphorylation site [posttranslational modification]
891974008100	intermolecular recognition site; other site
891974008101	dimerization interface [polypeptide binding]; other site
891974008102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974008103	DNA binding site [nucleotide binding]
891974008104	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
891974008105	dimer interface [polypeptide binding]; other site
891974008106	Cation efflux family; Region: Cation_efflux; cl00316
891974008107	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
891974008108	active site
891974008109	ADP/pyrophosphate binding site [chemical binding]; other site
891974008110	dimerization interface [polypeptide binding]; other site
891974008111	allosteric effector site; other site
891974008112	fructose-1,6-bisphosphate binding site; other site
891974008113	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974008114	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974008115	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
891974008116	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
891974008117	substrate binding site [chemical binding]; other site
891974008118	dimer interface [polypeptide binding]; other site
891974008119	catalytic triad [active]
891974008120	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
891974008121	ferredoxin-NADP reductase; Provisional; Region: PRK10926
891974008122	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
891974008123	FAD binding pocket [chemical binding]; other site
891974008124	FAD binding motif [chemical binding]; other site
891974008125	phosphate binding motif [ion binding]; other site
891974008126	beta-alpha-beta structure motif; other site
891974008127	NAD binding pocket [chemical binding]; other site
891974008128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008129	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
891974008130	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
891974008131	putative active site [active]
891974008132	glycerol kinase; Provisional; Region: glpK; PRK00047
891974008133	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
891974008134	N- and C-terminal domain interface [polypeptide binding]; other site
891974008135	active site
891974008136	MgATP binding site [chemical binding]; other site
891974008137	catalytic site [active]
891974008138	metal binding site [ion binding]; metal-binding site
891974008139	glycerol binding site [chemical binding]; other site
891974008140	homotetramer interface [polypeptide binding]; other site
891974008141	homodimer interface [polypeptide binding]; other site
891974008142	FBP binding site [chemical binding]; other site
891974008143	protein IIAGlc interface [polypeptide binding]; other site
891974008144	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
891974008145	amphipathic channel; other site
891974008146	Asn-Pro-Ala signature motifs; other site
891974008147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
891974008148	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
891974008149	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
891974008150	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
891974008151	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
891974008152	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
891974008153	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
891974008154	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
891974008155	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
891974008156	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
891974008157	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
891974008158	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
891974008159	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
891974008160	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
891974008161	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
891974008162	carboxyltransferase (CT) interaction site; other site
891974008163	biotinylation site [posttranslational modification]; other site
891974008164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008165	non-specific DNA binding site [nucleotide binding]; other site
891974008166	salt bridge; other site
891974008167	sequence-specific DNA binding site [nucleotide binding]; other site
891974008168	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
891974008169	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
891974008170	Zn2+ binding site [ion binding]; other site
891974008171	Mg2+ binding site [ion binding]; other site
891974008172	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974008173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974008174	putative Zn2+ binding site [ion binding]; other site
891974008175	putative DNA binding site [nucleotide binding]; other site
891974008176	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
891974008177	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
891974008178	Sulfatase; Region: Sulfatase; cl19157
891974008179	phosphoethanolamine transferase; Provisional; Region: PRK11560
891974008180	Sulfatase; Region: Sulfatase; cl19157
891974008181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974008182	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974008183	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974008184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974008185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008186	sugar efflux transporter; Region: 2A0120; TIGR00899
891974008187	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
891974008188	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974008189	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974008190	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974008191	catalytic residues [active]
891974008192	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974008193	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974008194	Synaptic Site I dimer interface [polypeptide binding]; other site
891974008195	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974008196	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974008197	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
891974008198	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
891974008199	Phage protein GP46; Region: GP46; pfam07409
891974008200	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
891974008201	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974008202	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974008203	DNA circularisation protein N-terminus; Region: DNA_circ_N; pfam07157
891974008204	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974008205	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
891974008206	Phage tail tube protein; Region: Tail_tube; pfam10618
891974008207	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
891974008208	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
891974008209	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
891974008210	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
891974008211	oligomerization interface [polypeptide binding]; other site
891974008212	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
891974008213	Phage capsid family; Region: Phage_capsid; pfam05065
891974008214	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
891974008215	oligomer interface [polypeptide binding]; other site
891974008216	active site residues [active]
891974008217	Phage portal protein; Region: Phage_portal; pfam04860
891974008218	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
891974008219	Phage Terminase; Region: Terminase_1; cl19862
891974008220	Phage terminase, small subunit; Region: Terminase_4; cl01525
891974008221	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
891974008222	active site
891974008223	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974008224	Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245
891974008225	ORF11CD3 domain; Region: ORF11CD3; pfam10549
891974008226	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
891974008227	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
891974008228	catalytic residues [active]
891974008229	DNA methylase; Region: N6_N4_Mtase; pfam01555
891974008230	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
891974008231	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
891974008232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974008233	Walker A motif; other site
891974008234	ATP binding site [chemical binding]; other site
891974008235	Walker B motif; other site
891974008236	arginine finger; other site
891974008237	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
891974008238	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
891974008239	Ash protein family; Region: Phage_ASH; pfam10554
891974008240	BRO family, N-terminal domain; Region: Bro-N; smart01040
891974008241	ORF6N domain; Region: ORF6N; pfam10543
891974008242	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
891974008243	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
891974008244	ssDNA binding site [nucleotide binding]; other site
891974008245	dimer interface [polypeptide binding]; other site
891974008246	tetramer (dimer of dimers) interface [polypeptide binding]; other site
891974008247	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
891974008248	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974008249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008250	non-specific DNA binding site [nucleotide binding]; other site
891974008251	salt bridge; other site
891974008252	sequence-specific DNA binding site [nucleotide binding]; other site
891974008253	hypothetical protein; Provisional; Region: PRK09956
891974008254	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
891974008255	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974008256	DNA binding site [nucleotide binding]
891974008257	active site
891974008258	Int/Topo IB signature motif; other site
891974008259	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
891974008260	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974008261	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974008262	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974008263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974008264	Transposase; Region: HTH_Tnp_1; cl17663
891974008265	Integrase core domain; Region: rve; pfam00665
891974008266	Integrase core domain; Region: rve_3; pfam13683
891974008267	carbon storage regulator; Provisional; Region: PRK01712
891974008268	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
891974008269	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
891974008270	motif 1; other site
891974008271	active site
891974008272	motif 2; other site
891974008273	motif 3; other site
891974008274	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
891974008275	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
891974008276	DHHA1 domain; Region: DHHA1; pfam02272
891974008277	recombination regulator RecX; Reviewed; Region: recX; PRK00117
891974008278	recombinase A; Provisional; Region: recA; PRK09354
891974008279	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
891974008280	hexamer interface [polypeptide binding]; other site
891974008281	Walker A motif; other site
891974008282	ATP binding site [chemical binding]; other site
891974008283	Walker B motif; other site
891974008284	Competence-damaged protein; Region: CinA; cl00666
891974008285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974008286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974008287	S-adenosylmethionine binding site [chemical binding]; other site
891974008288	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
891974008289	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
891974008290	PhnA protein; Region: PhnA; pfam03831
891974008291	Transglycosylase SLT domain; Region: SLT_2; cl19381
891974008292	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974008293	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974008294	catalytic residue [active]
891974008295	Transglycosylase SLT domain; Region: SLT_2; cl19381
891974008296	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
891974008297	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
891974008298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974008299	Transposase; Region: HTH_Tnp_1; cl17663
891974008300	Integrase core domain; Region: rve; pfam00665
891974008301	Integrase core domain; Region: rve_3; pfam13683
891974008302	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
891974008303	lipoprotein; Provisional; Region: PRK10759
891974008304	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
891974008305	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
891974008306	domain interface [polypeptide binding]; other site
891974008307	putative active site [active]
891974008308	catalytic site [active]
891974008309	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
891974008310	domain interface [polypeptide binding]; other site
891974008311	putative active site [active]
891974008312	catalytic site [active]
891974008313	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
891974008314	CoA binding domain; Region: CoA_binding_2; pfam13380
891974008315	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
891974008316	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
891974008317	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974008318	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
891974008319	Uncharacterized conserved protein [Function unknown]; Region: COG3148
891974008320	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
891974008321	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
891974008322	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974008323	putative methyltransferase; Provisional; Region: PRK10864
891974008324	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
891974008325	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
891974008326	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
891974008327	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
891974008328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008329	putative substrate translocation pore; other site
891974008330	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
891974008331	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974008332	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974008333	transcriptional repressor MprA; Provisional; Region: PRK10870
891974008334	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974008335	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
891974008336	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
891974008337	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
891974008338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974008339	dimer interface [polypeptide binding]; other site
891974008340	conserved gate region; other site
891974008341	putative PBP binding loops; other site
891974008342	ABC-ATPase subunit interface; other site
891974008343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974008344	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
891974008345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974008346	Walker A/P-loop; other site
891974008347	ATP binding site [chemical binding]; other site
891974008348	Q-loop/lid; other site
891974008349	ABC transporter signature motif; other site
891974008350	Walker B; other site
891974008351	D-loop; other site
891974008352	H-loop/switch region; other site
891974008353	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
891974008354	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
891974008355	dimer interface [polypeptide binding]; other site
891974008356	putative radical transfer pathway; other site
891974008357	diiron center [ion binding]; other site
891974008358	tyrosyl radical; other site
891974008359	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
891974008360	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
891974008361	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
891974008362	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
891974008363	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
891974008364	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
891974008365	catalytic residues [active]
891974008366	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
891974008367	hypothetical protein; Provisional; Region: PRK10556
891974008368	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
891974008369	S-methylmethionine transporter; Provisional; Region: PRK11387
891974008370	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
891974008371	PEGA domain; Region: PEGA; pfam08308
891974008372	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
891974008373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974008374	Coenzyme A binding pocket [chemical binding]; other site
891974008375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974008376	ATP binding site [chemical binding]; other site
891974008377	Q-loop/lid; other site
891974008378	ABC transporter signature motif; other site
891974008379	Walker B; other site
891974008380	D-loop; other site
891974008381	H-loop/switch region; other site
891974008382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974008383	Walker A/P-loop; other site
891974008384	ATP binding site [chemical binding]; other site
891974008385	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974008386	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
891974008387	Q-loop/lid; other site
891974008388	ABC transporter signature motif; other site
891974008389	Walker B; other site
891974008390	D-loop; other site
891974008391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974008392	Walker A/P-loop; other site
891974008393	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
891974008394	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
891974008395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974008396	dimer interface [polypeptide binding]; other site
891974008397	conserved gate region; other site
891974008398	putative PBP binding loops; other site
891974008399	ABC-ATPase subunit interface; other site
891974008400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974008401	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
891974008402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974008403	dimer interface [polypeptide binding]; other site
891974008404	conserved gate region; other site
891974008405	putative PBP binding loops; other site
891974008406	ABC-ATPase subunit interface; other site
891974008407	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974008408	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
891974008409	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
891974008410	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
891974008411	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
891974008412	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
891974008413	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
891974008414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974008415	short chain dehydrogenase; Region: adh_short; pfam00106
891974008416	NAD(P) binding site [chemical binding]; other site
891974008417	active site
891974008418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
891974008419	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
891974008420	Integrase core domain; Region: rve; pfam00665
891974008421	Integrase core domain; Region: rve_3; pfam13683
891974008422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974008423	Transposase; Region: HTH_Tnp_1; cl17663
891974008424	flagellar capping protein; Reviewed; Region: fliD; PRK08032
891974008425	Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465
891974008426	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
891974008427	flagellar protein FliS; Validated; Region: fliS; PRK05685
891974008428	Flagellar protein FliT; Region: FliT; cl05125
891974008429	Methyltransferase domain; Region: Methyltransf_24; pfam13578
891974008430	Methyltransferase domain; Region: Methyltransf_24; pfam13578
891974008431	lipoprotein; Provisional; Region: PRK10397
891974008432	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
891974008433	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974008434	dimer interface [polypeptide binding]; other site
891974008435	putative CheW interface [polypeptide binding]; other site
891974008436	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974008437	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
891974008438	DinI-like family; Region: DinI; cl11630
891974008439	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
891974008440	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
891974008441	trimer interface [polypeptide binding]; other site
891974008442	active site
891974008443	substrate binding site [chemical binding]; other site
891974008444	CoA binding site [chemical binding]; other site
891974008445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008446	non-specific DNA binding site [nucleotide binding]; other site
891974008447	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
891974008448	salt bridge; other site
891974008449	sequence-specific DNA binding site [nucleotide binding]; other site
891974008450	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
891974008451	Catalytic site [active]
891974008452	Sensors of blue-light using FAD; Region: BLUF; smart01034
891974008453	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974008454	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
891974008455	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
891974008456	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
891974008457	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
891974008458	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
891974008459	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
891974008460	FliG N-terminal domain; Region: FliG_N; pfam14842
891974008461	FliG middle domain; Region: FliG_M; pfam14841
891974008462	FliG C-terminal domain; Region: FliG_C; pfam01706
891974008463	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
891974008464	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
891974008465	Walker A motif/ATP binding site; other site
891974008466	Walker B motif; other site
891974008467	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
891974008468	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
891974008469	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
891974008470	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
891974008471	Flagellar motor switch protein FliM; Region: FliM; pfam02154
891974008472	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
891974008473	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
891974008474	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
891974008475	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
891974008476	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
891974008477	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
891974008478	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
891974008479	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
891974008480	ligand binding site [chemical binding]; other site
891974008481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974008482	dimer interface [polypeptide binding]; other site
891974008483	putative CheW interface [polypeptide binding]; other site
891974008484	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
891974008485	hypothetical protein; Provisional; Region: PRK10708
891974008486	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
891974008487	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
891974008488	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974008489	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
891974008490	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974008491	active site
891974008492	motif I; other site
891974008493	motif II; other site
891974008494	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
891974008495	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974008496	metal binding site [ion binding]; metal-binding site
891974008497	active site
891974008498	I-site; other site
891974008499	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
891974008500	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
891974008501	Protein of unknown function (DUF808); Region: DUF808; cl01002
891974008502	Protein of unknown function (DUF808); Region: DUF808; cl01002
891974008503	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
891974008504	additional DNA contacts [nucleotide binding]; other site
891974008505	mismatch recognition site; other site
891974008506	active site
891974008507	zinc binding site [ion binding]; other site
891974008508	DNA intercalation site [nucleotide binding]; other site
891974008509	DNA cytosine methylase; Provisional; Region: PRK10458
891974008510	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
891974008511	cofactor binding site; other site
891974008512	DNA binding site [nucleotide binding]
891974008513	substrate interaction site [chemical binding]; other site
891974008514	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
891974008515	dimer interface [polypeptide binding]; other site
891974008516	ligand binding site [chemical binding]; other site
891974008517	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
891974008518	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
891974008519	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
891974008520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974008521	motif II; other site
891974008522	DNA repair protein RadA; Region: sms; TIGR00416
891974008523	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
891974008524	Walker A motif/ATP binding site; other site
891974008525	ATP binding site [chemical binding]; other site
891974008526	Walker B motif; other site
891974008527	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
891974008528	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008529	non-specific DNA binding site [nucleotide binding]; other site
891974008530	salt bridge; other site
891974008531	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
891974008532	sequence-specific DNA binding site [nucleotide binding]; other site
891974008533	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
891974008534	active site
891974008535	(T/H)XGH motif; other site
891974008536	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
891974008537	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
891974008538	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
891974008539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974008540	ABC transporter; Region: ABC_tran_2; pfam12848
891974008541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974008542	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
891974008543	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974008544	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974008545	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
891974008546	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
891974008547	Walker A/P-loop; other site
891974008548	ATP binding site [chemical binding]; other site
891974008549	Q-loop/lid; other site
891974008550	ABC transporter signature motif; other site
891974008551	Walker B; other site
891974008552	D-loop; other site
891974008553	H-loop/switch region; other site
891974008554	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
891974008555	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
891974008556	Walker A/P-loop; other site
891974008557	ATP binding site [chemical binding]; other site
891974008558	Q-loop/lid; other site
891974008559	ABC transporter signature motif; other site
891974008560	Walker B; other site
891974008561	D-loop; other site
891974008562	H-loop/switch region; other site
891974008563	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974008564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974008565	Transposase; Region: HTH_Tnp_1; cl17663
891974008566	Integrase core domain; Region: rve; pfam00665
891974008567	Integrase core domain; Region: rve_3; pfam13683
891974008568	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
891974008569	tetramer interface [polypeptide binding]; other site
891974008570	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974008571	active site
891974008572	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
891974008573	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
891974008574	XdhC Rossmann domain; Region: XdhC_C; pfam13478
891974008575	PhoH-like protein; Region: PhoH; cl17668
891974008576	PhoH-like protein; Region: PhoH; cl17668
891974008577	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
891974008578	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
891974008579	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
891974008580	Imelysin; Region: Peptidase_M75; pfam09375
891974008581	Iron permease FTR1 family; Region: FTR1; cl00475
891974008582	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
891974008583	Na binding site [ion binding]; other site
891974008584	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
891974008585	Predicted transcriptional regulator [Transcription]; Region: COG3905
891974008586	DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850
891974008587	Proline dehydrogenase; Region: Pro_dh; pfam01619
891974008588	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
891974008589	Glutamate binding site [chemical binding]; other site
891974008590	NAD binding site [chemical binding]; other site
891974008591	catalytic residues [active]
891974008592	Predicted membrane protein [Function unknown]; Region: COG4763
891974008593	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
891974008594	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
891974008595	Walker A/P-loop; other site
891974008596	ATP binding site [chemical binding]; other site
891974008597	Q-loop/lid; other site
891974008598	ABC transporter signature motif; other site
891974008599	Walker B; other site
891974008600	D-loop; other site
891974008601	H-loop/switch region; other site
891974008602	Phage terminase large subunit; Region: Terminase_3; cl12054
891974008603	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
891974008604	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
891974008605	dimer interface [polypeptide binding]; other site
891974008606	active site
891974008607	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974008608	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
891974008609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008610	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974008611	non-specific DNA binding site [nucleotide binding]; other site
891974008612	salt bridge; other site
891974008613	sequence-specific DNA binding site [nucleotide binding]; other site
891974008614	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
891974008615	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
891974008616	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
891974008617	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
891974008618	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
891974008619	conserved cys residue [active]
891974008620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974008621	FlgN protein; Region: FlgN; cl09176
891974008622	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
891974008623	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
891974008624	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
891974008625	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
891974008626	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
891974008627	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
891974008628	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
891974008629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
891974008630	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
891974008631	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974008632	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974008633	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974008634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974008635	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974008636	dimerization interface [polypeptide binding]; other site
891974008637	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
891974008638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974008639	ATP binding site [chemical binding]; other site
891974008640	Mg2+ binding site [ion binding]; other site
891974008641	G-X-G motif; other site
891974008642	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
891974008643	anchoring element; other site
891974008644	dimer interface [polypeptide binding]; other site
891974008645	ATP binding site [chemical binding]; other site
891974008646	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
891974008647	active site
891974008648	metal binding site [ion binding]; metal-binding site
891974008649	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
891974008650	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
891974008651	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
891974008652	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
891974008653	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
891974008654	hexamer interface [polypeptide binding]; other site
891974008655	active site
891974008656	metal binding site [ion binding]; metal-binding site
891974008657	Protein of unknown function (DUF1249); Region: DUF1249; cl01223
891974008658	Protein of unknown function (DUF1249); Region: DUF1249; cl01223
891974008659	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
891974008660	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
891974008661	dimer interface [polypeptide binding]; other site
891974008662	ADP-ribose binding site [chemical binding]; other site
891974008663	active site
891974008664	nudix motif; other site
891974008665	metal binding site [ion binding]; metal-binding site
891974008666	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
891974008667	Outer membrane efflux protein; Region: OEP; pfam02321
891974008668	Outer membrane efflux protein; Region: OEP; pfam02321
891974008669	hypothetical protein; Provisional; Region: PRK11653
891974008670	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
891974008671	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
891974008672	putative active site [active]
891974008673	metal binding site [ion binding]; metal-binding site
891974008674	zinc transporter ZupT; Provisional; Region: PRK04201
891974008675	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
891974008676	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
891974008677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
891974008678	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
891974008679	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
891974008680	putative ribose interaction site [chemical binding]; other site
891974008681	putative ADP binding site [chemical binding]; other site
891974008682	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
891974008683	active site
891974008684	nucleotide binding site [chemical binding]; other site
891974008685	HIGH motif; other site
891974008686	KMSKS motif; other site
891974008687	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
891974008688	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
891974008689	metal binding triad; other site
891974008690	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
891974008691	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
891974008692	metal binding triad; other site
891974008693	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
891974008694	Uncharacterized conserved protein [Function unknown]; Region: COG3025
891974008695	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
891974008696	putative active site [active]
891974008697	putative metal binding residues [ion binding]; other site
891974008698	signature motif; other site
891974008699	putative triphosphate binding site [ion binding]; other site
891974008700	SH3 domain-containing protein; Provisional; Region: PRK10884
891974008701	Bacterial SH3 domain homologues; Region: SH3b; smart00287
891974008702	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
891974008703	Poly A polymerase head domain; Region: PolyA_pol; pfam01743
891974008704	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
891974008705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
891974008706	Zn2+ binding site [ion binding]; other site
891974008707	Mg2+ binding site [ion binding]; other site
891974008708	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
891974008709	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
891974008710	homooctamer interface [polypeptide binding]; other site
891974008711	active site
891974008712	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
891974008713	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
891974008714	UGMP family protein; Validated; Region: PRK09604
891974008715	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
891974008716	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
891974008717	DNA primase; Validated; Region: dnaG; PRK05667
891974008718	CHC2 zinc finger; Region: zf-CHC2; pfam01807
891974008719	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
891974008720	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
891974008721	active site
891974008722	metal binding site [ion binding]; metal-binding site
891974008723	interdomain interaction site; other site
891974008724	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
891974008725	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
891974008726	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
891974008727	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
891974008728	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
891974008729	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
891974008730	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
891974008731	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
891974008732	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
891974008733	DNA binding residues [nucleotide binding]
891974008734	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
891974008735	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
891974008736	active site
891974008737	SUMO-1 interface [polypeptide binding]; other site
891974008738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974008739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974008740	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
891974008741	classical (c) SDRs; Region: SDR_c; cd05233
891974008742	NAD(P) binding site [chemical binding]; other site
891974008743	active site
891974008744	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
891974008745	RepB plasmid partitioning protein; Region: RepB; pfam07506
891974008746	ParB-like nuclease domain; Region: ParBc; pfam02195
891974008747	RepB plasmid partitioning protein; Region: RepB; pfam07506
891974008748	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
891974008749	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974008750	catalytic residues [active]
891974008751	Protein of unknown function (DUF796); Region: DUF796; cl01226
891974008752	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
891974008753	active site
891974008754	multimer interface [polypeptide binding]; other site
891974008755	Protein of unknown function (DUF877); Region: DUF877; cl05484
891974008756	Protein of unknown function (DUF877); Region: DUF877; cl05484
891974008757	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
891974008758	ImpA-related N-terminal; Region: ImpA-rel_N; cl19907
891974008759	ImpA-related N-terminal; Region: ImpA-rel_N; cl19907
891974008760	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
891974008761	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
891974008762	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
891974008763	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
891974008764	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
891974008765	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
891974008766	G1 box; other site
891974008767	GTP/Mg2+ binding site [chemical binding]; other site
891974008768	G2 box; other site
891974008769	G3 box; other site
891974008770	Switch II region; other site
891974008771	G4 box; other site
891974008772	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
891974008773	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
891974008774	ligand binding site [chemical binding]; other site
891974008775	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
891974008776	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
891974008777	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
891974008778	Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406
891974008779	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
891974008780	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
891974008781	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974008782	motif II; other site
891974008783	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
891974008784	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974008785	Coenzyme A binding pocket [chemical binding]; other site
891974008786	DNA polymerase III subunit psi; Validated; Region: PRK06856
891974008787	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
891974008788	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
891974008789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974008790	S-adenosylmethionine binding site [chemical binding]; other site
891974008791	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
891974008792	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
891974008793	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974008794	metal binding site [ion binding]; metal-binding site
891974008795	active site
891974008796	I-site; other site
891974008797	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
891974008798	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
891974008799	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
891974008800	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
891974008801	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
891974008802	putative deacylase active site [active]
891974008803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008804	metabolite-proton symporter; Region: 2A0106; TIGR00883
891974008805	putative substrate translocation pore; other site
891974008806	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974008807	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974008808	DNA binding site [nucleotide binding]
891974008809	domain linker motif; other site
891974008810	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974008811	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
891974008812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008813	putative substrate translocation pore; other site
891974008814	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
891974008815	catalytic core [active]
891974008816	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
891974008817	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
891974008818	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
891974008819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974008820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974008821	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
891974008822	putative effector binding pocket; other site
891974008823	dimerization interface [polypeptide binding]; other site
891974008824	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
891974008825	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
891974008826	Sulfatase; Region: Sulfatase; cl19157
891974008827	Sulfatase; Region: Sulfatase; cl19157
891974008828	Sulfatase; Region: Sulfatase; cl19157
891974008829	Sulfatase; Region: Sulfatase; cl19157
891974008830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974008831	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
891974008832	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
891974008833	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974008834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974008835	homodimer interface [polypeptide binding]; other site
891974008836	catalytic residue [active]
891974008837	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974008838	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
891974008839	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
891974008840	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
891974008841	Beta-lactamase; Region: Beta-lactamase; pfam00144
891974008842	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
891974008843	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
891974008844	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
891974008845	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
891974008846	hypothetical protein; Provisional; Region: PRK10396
891974008847	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
891974008848	SEC-C motif; Region: SEC-C; pfam02810
891974008849	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
891974008850	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974008851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008852	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974008853	putative substrate translocation pore; other site
891974008854	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
891974008855	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974008856	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
891974008857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008858	putative transporter; Provisional; Region: PRK12382
891974008859	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
891974008860	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
891974008861	putative NAD(P) binding site [chemical binding]; other site
891974008862	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974008863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974008864	non-specific DNA binding site [nucleotide binding]; other site
891974008865	salt bridge; other site
891974008866	sequence-specific DNA binding site [nucleotide binding]; other site
891974008867	Domain of unknown function (DUF955); Region: DUF955; cl01076
891974008868	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
891974008869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974008870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974008871	dimerization interface [polypeptide binding]; other site
891974008872	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974008873	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974008874	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
891974008875	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
891974008876	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
891974008877	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974008878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974008879	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
891974008880	D5 N terminal like; Region: D5_N; smart00885
891974008881	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
891974008882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
891974008883	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
891974008884	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
891974008885	active site
891974008886	metal binding site [ion binding]; metal-binding site
891974008887	interdomain interaction site; other site
891974008888	Ash protein family; Region: Phage_ASH; pfam10554
891974008889	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
891974008890	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
891974008891	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
891974008892	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
891974008893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974008894	Transposase; Region: HTH_Tnp_1; cl17663
891974008895	Integrase core domain; Region: rve; pfam00665
891974008896	Integrase core domain; Region: rve_3; pfam13683
891974008897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974008898	ATP binding site [chemical binding]; other site
891974008899	Mg2+ binding site [ion binding]; other site
891974008900	G-X-G motif; other site
891974008901	PerC transcriptional activator; Region: PerC; pfam06069
891974008902	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
891974008903	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
891974008904	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
891974008905	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
891974008906	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
891974008907	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
891974008908	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
891974008909	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
891974008910	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
891974008911	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974008912	catalytic loop [active]
891974008913	iron binding site [ion binding]; other site
891974008914	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
891974008915	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
891974008916	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
891974008917	FAD binding pocket [chemical binding]; other site
891974008918	FAD binding motif [chemical binding]; other site
891974008919	phosphate binding motif [ion binding]; other site
891974008920	beta-alpha-beta structure motif; other site
891974008921	NAD binding pocket [chemical binding]; other site
891974008922	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974008923	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
891974008924	N-terminal domain interface [polypeptide binding]; other site
891974008925	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974008926	dimer interface [polypeptide binding]; other site
891974008927	substrate binding pocket (H-site) [chemical binding]; other site
891974008928	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
891974008929	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
891974008930	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974008931	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974008932	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
891974008933	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
891974008934	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
891974008935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974008936	putative substrate translocation pore; other site
891974008937	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
891974008938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974008939	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
891974008940	dimerization interface [polypeptide binding]; other site
891974008941	substrate binding pocket [chemical binding]; other site
891974008942	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974008943	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974008944	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974008945	mannonate dehydratase; Provisional; Region: PRK03906
891974008946	D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786
891974008947	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
891974008948	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
891974008949	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974008950	Mor transcription activator family; Region: Mor; pfam08765
891974008951	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974008952	LysE type translocator; Region: LysE; cl00565
891974008953	LysE type translocator; Region: LysE; cl00565
891974008954	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974008955	Mor transcription activator family; Region: Mor; pfam08765
891974008956	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974008957	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974008958	NAD(P) binding site [chemical binding]; other site
891974008959	catalytic residues [active]
891974008960	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974008961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974008962	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
891974008963	EamA-like transporter family; Region: EamA; pfam00892
891974008964	EamA-like transporter family; Region: EamA; cl17759
891974008965	CoA-transferase family III; Region: CoA_transf_3; cl19215
891974008966	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
891974008967	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
891974008968	active site
891974008969	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
891974008970	active site
891974008971	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; cl19132
891974008972	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974008973	Trehalase; Region: Trehalase; cl17346
891974008974	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
891974008975	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
891974008976	N-terminal plug; other site
891974008977	ligand-binding site [chemical binding]; other site
891974008978	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974008979	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
891974008980	Flagellar regulator YcgR; Region: YcgR; pfam07317
891974008981	PilZ domain; Region: PilZ; pfam07238
891974008982	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
891974008983	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
891974008984	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974008985	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974008986	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974008987	catalytic residue [active]
891974008988	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
891974008989	dimer interface [polypeptide binding]; other site
891974008990	catalytic triad [active]
891974008991	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
891974008992	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
891974008993	Protein of unknown function (DUF2767); Region: DUF2767; cl08104
891974008994	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
891974008995	YcfA-like protein; Region: YcfA; cl00752
891974008996	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
891974008997	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
891974008998	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
891974008999	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974009000	isocitrate dehydrogenase; Reviewed; Region: PRK07006
891974009001	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
891974009002	active site
891974009003	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
891974009004	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
891974009005	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
891974009006	Ligand Binding Site [chemical binding]; other site
891974009007	putative lysogenization regulator; Reviewed; Region: PRK00218
891974009008	adenylosuccinate lyase; Provisional; Region: PRK09285
891974009009	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
891974009010	tetramer interface [polypeptide binding]; other site
891974009011	active site
891974009012	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
891974009013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974009014	active site
891974009015	phosphorylation site [posttranslational modification]
891974009016	intermolecular recognition site; other site
891974009017	dimerization interface [polypeptide binding]; other site
891974009018	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974009019	DNA binding site [nucleotide binding]
891974009020	sensor protein PhoQ; Provisional; Region: PRK10815
891974009021	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
891974009022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974009023	dimer interface [polypeptide binding]; other site
891974009024	phosphorylation site [posttranslational modification]
891974009025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974009026	ATP binding site [chemical binding]; other site
891974009027	Mg2+ binding site [ion binding]; other site
891974009028	G-X-G motif; other site
891974009029	Uncharacterized conserved protein [Function unknown]; Region: COG2850
891974009030	Cupin-like domain; Region: Cupin_8; cl19305
891974009031	peptidase T-like protein; Region: PepT-like; TIGR01883
891974009032	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
891974009033	metal binding site [ion binding]; metal-binding site
891974009034	dimer interface [polypeptide binding]; other site
891974009035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009036	Walker A/P-loop; other site
891974009037	ATP binding site [chemical binding]; other site
891974009038	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009039	ABC transporter signature motif; other site
891974009040	Walker B; other site
891974009041	D-loop; other site
891974009042	H-loop/switch region; other site
891974009043	TOBE domain; Region: TOBE_2; pfam08402
891974009044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974009045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974009046	dimer interface [polypeptide binding]; other site
891974009047	putative PBP binding loops; other site
891974009048	ABC-ATPase subunit interface; other site
891974009049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974009050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974009051	dimer interface [polypeptide binding]; other site
891974009052	conserved gate region; other site
891974009053	putative PBP binding loops; other site
891974009054	ABC-ATPase subunit interface; other site
891974009055	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974009056	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
891974009057	NAD+ binding site [chemical binding]; other site
891974009058	substrate binding site [chemical binding]; other site
891974009059	Zn binding site [ion binding]; other site
891974009060	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
891974009061	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
891974009062	FtsX-like permease family; Region: FtsX; pfam02687
891974009063	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
891974009064	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
891974009065	Walker A/P-loop; other site
891974009066	ATP binding site [chemical binding]; other site
891974009067	Q-loop/lid; other site
891974009068	ABC transporter signature motif; other site
891974009069	Walker B; other site
891974009070	D-loop; other site
891974009071	H-loop/switch region; other site
891974009072	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
891974009073	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
891974009074	FtsX-like permease family; Region: FtsX; pfam02687
891974009075	transcription-repair coupling factor; Provisional; Region: PRK10689
891974009076	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
891974009077	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
891974009078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974009079	ATP binding site [chemical binding]; other site
891974009080	putative Mg++ binding site [ion binding]; other site
891974009081	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974009082	nucleotide binding region [chemical binding]; other site
891974009083	ATP-binding site [chemical binding]; other site
891974009084	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
891974009085	hypothetical protein; Provisional; Region: PRK11280
891974009086	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974009087	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
891974009088	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
891974009089	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
891974009090	beta-hexosaminidase; Provisional; Region: PRK05337
891974009091	Phosphotransferase enzyme family; Region: APH; pfam01636
891974009092	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
891974009093	active site
891974009094	substrate binding site [chemical binding]; other site
891974009095	ATP binding site [chemical binding]; other site
891974009096	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
891974009097	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
891974009098	putative dimer interface [polypeptide binding]; other site
891974009099	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
891974009100	nucleotide binding site/active site [active]
891974009101	HIT family signature motif; other site
891974009102	catalytic residue [active]
891974009103	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974009104	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
891974009105	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974009106	active site turn [active]
891974009107	phosphorylation site [posttranslational modification]
891974009108	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164
891974009109	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164
891974009110	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
891974009111	active site
891974009112	DNA polymerase III subunit delta'; Validated; Region: PRK07993
891974009113	DNA polymerase III subunit delta'; Validated; Region: PRK08485
891974009114	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
891974009115	thymidylate kinase; Validated; Region: tmk; PRK00698
891974009116	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
891974009117	TMP-binding site; other site
891974009118	ATP-binding site [chemical binding]; other site
891974009119	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
891974009120	dimerization interface [polypeptide binding]; other site
891974009121	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
891974009122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009123	catalytic residue [active]
891974009124	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
891974009125	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
891974009126	dimer interface [polypeptide binding]; other site
891974009127	active site
891974009128	acyl carrier protein; Provisional; Region: acpP; PRK00982
891974009129	Acyl transferase domain; Region: Acyl_transf_1; cl08282
891974009130	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
891974009131	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
891974009132	NAD(P) binding site [chemical binding]; other site
891974009133	homotetramer interface [polypeptide binding]; other site
891974009134	homodimer interface [polypeptide binding]; other site
891974009135	active site
891974009136	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
891974009137	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
891974009138	dimer interface [polypeptide binding]; other site
891974009139	active site
891974009140	CoA binding pocket [chemical binding]; other site
891974009141	putative phosphate acyltransferase; Provisional; Region: PRK05331
891974009142	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
891974009143	hypothetical protein; Provisional; Region: PRK11193
891974009144	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
891974009145	active site
891974009146	dimer interface [polypeptide binding]; other site
891974009147	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
891974009148	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974009149	RNA binding surface [nucleotide binding]; other site
891974009150	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
891974009151	active site
891974009152	ribonuclease E; Reviewed; Region: rne; PRK10811
891974009153	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
891974009154	homodimer interface [polypeptide binding]; other site
891974009155	oligonucleotide binding site [chemical binding]; other site
891974009156	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
891974009157	Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
891974009158	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
891974009159	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
891974009160	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
891974009161	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
891974009162	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
891974009163	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
891974009164	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
891974009165	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
891974009166	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
891974009167	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
891974009168	Flagellar L-ring protein; Region: FlgH; pfam02107
891974009169	Flagellar L-ring protein; Region: FlgH; cl19182
891974009170	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
891974009171	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
891974009172	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
891974009173	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
891974009174	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
891974009175	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
891974009176	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
891974009177	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
891974009178	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
891974009179	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
891974009180	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
891974009181	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
891974009182	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
891974009183	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
891974009184	FlgN protein; Region: FlgN; cl09176
891974009185	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
891974009186	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
891974009187	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974009188	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974009189	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974009190	Protein of unknown function, DUF480; Region: DUF480; cl01209
891974009191	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
891974009192	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974009193	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974009194	N-terminal domain interface [polypeptide binding]; other site
891974009195	lipoprotein; Provisional; Region: PRK10598
891974009196	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
891974009197	active site
891974009198	dimer interface [polypeptide binding]; other site
891974009199	substrate binding pocket [chemical binding]; other site
891974009200	DinI-like family; Region: DinI; cl11630
891974009201	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
891974009202	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974009203	FAD dependent oxidoreductase; Region: DAO; pfam01266
891974009204	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974009205	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
891974009206	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
891974009207	YceI-like domain; Region: YceI; cl01001
891974009208	YceI-like domain; Region: YceI; cl01001
891974009209	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
891974009210	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
891974009211	active site residue [active]
891974009212	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
891974009213	putative acyl-acceptor binding pocket; other site
891974009214	MsyB protein; Region: MsyB; cl08181
891974009215	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
891974009216	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
891974009217	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
891974009218	Ligand binding site; other site
891974009219	DXD motif; other site
891974009220	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
891974009221	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
891974009222	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
891974009223	PLD-like domain; Region: PLDc_2; pfam13091
891974009224	putative active site [active]
891974009225	catalytic site [active]
891974009226	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
891974009227	PLD-like domain; Region: PLDc_2; pfam13091
891974009228	putative active site [active]
891974009229	catalytic site [active]
891974009230	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974009231	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
891974009232	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
891974009233	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
891974009234	dimer interface [polypeptide binding]; other site
891974009235	active site
891974009236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974009237	NAD(P) binding site [chemical binding]; other site
891974009238	active site
891974009239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974009240	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
891974009241	putative active site 1 [active]
891974009242	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
891974009243	active site
891974009244	Predicted exporter [General function prediction only]; Region: COG4258
891974009245	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
891974009246	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
891974009247	active site
891974009248	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
891974009249	putative acyl-acceptor binding pocket; other site
891974009250	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974009251	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974009252	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
891974009253	active site
891974009254	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
891974009255	active site 2 [active]
891974009256	active site 1 [active]
891974009257	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
891974009258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974009259	acyl-activating enzyme (AAE) consensus motif; other site
891974009260	active site
891974009261	AMP binding site [chemical binding]; other site
891974009262	CoA binding site [chemical binding]; other site
891974009263	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974009264	Predicted membrane protein [Function unknown]; Region: COG4648
891974009265	acyl carrier protein; Provisional; Region: PRK05350
891974009266	Phosphopantetheine attachment site; Region: PP-binding; cl09936
891974009267	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
891974009268	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
891974009269	putative acyl-acceptor binding pocket; other site
891974009270	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
891974009271	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
891974009272	Outer membrane efflux protein; Region: OEP; pfam02321
891974009273	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
891974009274	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
891974009275	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974009276	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974009277	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
891974009278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009279	putative substrate translocation pore; other site
891974009280	Transcriptional regulators [Transcription]; Region: MarR; COG1846
891974009281	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
891974009282	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
891974009283	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
891974009284	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
891974009285	Sulfate transporter family; Region: Sulfate_transp; cl19250
891974009286	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
891974009287	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
891974009288	Squalene epoxidase; Region: SE; cl17314
891974009289	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
891974009290	Cupin; Region: Cupin_6; pfam12852
891974009291	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974009292	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
891974009293	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
891974009294	excinuclease ABC, C subunit; Region: uvrC; TIGR00194
891974009295	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
891974009296	GIY-YIG motif/motif A; other site
891974009297	active site
891974009298	catalytic site [active]
891974009299	putative DNA binding site [nucleotide binding]; other site
891974009300	metal binding site [ion binding]; metal-binding site
891974009301	UvrB/uvrC motif; Region: UVR; pfam02151
891974009302	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
891974009303	response regulator; Provisional; Region: PRK09483
891974009304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974009305	active site
891974009306	phosphorylation site [posttranslational modification]
891974009307	intermolecular recognition site; other site
891974009308	dimerization interface [polypeptide binding]; other site
891974009309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974009310	DNA binding residues [nucleotide binding]
891974009311	dimerization interface [polypeptide binding]; other site
891974009312	hypothetical protein; Provisional; Region: PRK10613
891974009313	Autoinducer synthetase; Region: Autoind_synth; cl17404
891974009314	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
891974009315	DNA binding residues [nucleotide binding]
891974009316	dimerization interface [polypeptide binding]; other site
891974009317	Autoinducer binding domain; Region: Autoind_bind; pfam03472
891974009318	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
891974009319	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
891974009320	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
891974009321	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
891974009322	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
891974009323	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
891974009324	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
891974009325	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974009326	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
891974009327	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
891974009328	active site
891974009329	dimer interface [polypeptide binding]; other site
891974009330	non-prolyl cis peptide bond; other site
891974009331	insertion regions; other site
891974009332	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
891974009333	catalytic triad [active]
891974009334	conserved cis-peptide bond; other site
891974009335	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974009336	homotrimer interaction site [polypeptide binding]; other site
891974009337	putative active site [active]
891974009338	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974009339	pyrimidine utilization protein D; Region: RutD; TIGR03611
891974009340	Flavin Reductases; Region: FlaRed; cl00801
891974009341	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974009342	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974009343	catalytic residues [active]
891974009344	catalytic nucleophile [active]
891974009345	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974009346	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974009347	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974009348	Synaptic Site I dimer interface [polypeptide binding]; other site
891974009349	DNA binding site [nucleotide binding]
891974009350	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974009351	DNA-binding interface [nucleotide binding]; DNA binding site
891974009352	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974009353	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974009354	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974009355	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974009356	multiple promoter invertase; Provisional; Region: mpi; PRK13413
891974009357	catalytic residues [active]
891974009358	catalytic nucleophile [active]
891974009359	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974009360	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974009361	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974009362	Synaptic Site I dimer interface [polypeptide binding]; other site
891974009363	DNA binding site [nucleotide binding]
891974009364	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974009365	DNA-binding interface [nucleotide binding]; DNA binding site
891974009366	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
891974009367	FAD binding domain; Region: FAD_binding_4; pfam01565
891974009368	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
891974009369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974009370	dimer interface [polypeptide binding]; other site
891974009371	conserved gate region; other site
891974009372	putative PBP binding loops; other site
891974009373	ABC-ATPase subunit interface; other site
891974009374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009375	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
891974009376	ABC transporter signature motif; other site
891974009377	Walker B; other site
891974009378	D-loop; other site
891974009379	H-loop/switch region; other site
891974009380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009381	Walker A/P-loop; other site
891974009382	ATP binding site [chemical binding]; other site
891974009383	Q-loop/lid; other site
891974009384	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
891974009385	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974009386	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974009387	Creatinine amidohydrolase; Region: Creatininase; pfam02633
891974009388	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974009389	homotrimer interaction site [polypeptide binding]; other site
891974009390	putative active site [active]
891974009391	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
891974009392	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974009393	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974009394	active site
891974009395	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
891974009396	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
891974009397	FMN-binding pocket [chemical binding]; other site
891974009398	flavin binding motif; other site
891974009399	phosphate binding motif [ion binding]; other site
891974009400	beta-alpha-beta structure motif; other site
891974009401	NAD binding pocket [chemical binding]; other site
891974009402	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
891974009403	catalytic loop [active]
891974009404	iron binding site [ion binding]; other site
891974009405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009406	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974009407	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974009408	dimerization interface [polypeptide binding]; other site
891974009409	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
891974009410	iron-sulfur cluster [ion binding]; other site
891974009411	[2Fe-2S] cluster binding site [ion binding]; other site
891974009412	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
891974009413	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974009414	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974009415	Reductase C-terminal; Region: Reductase_C; pfam14759
891974009416	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
891974009417	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
891974009418	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
891974009419	hypothetical protein; Validated; Region: PRK00124
891974009420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
891974009421	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
891974009422	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
891974009423	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
891974009424	ADP binding site [chemical binding]; other site
891974009425	magnesium binding site [ion binding]; other site
891974009426	putative shikimate binding site; other site
891974009427	hypothetical protein; Provisional; Region: PRK10380
891974009428	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
891974009429	AroM protein; Region: AroM; cl17601
891974009430	AroM protein; Region: AroM; cl17601
891974009431	hypothetical protein; Provisional; Region: PRK10579
891974009432	recombination associated protein; Reviewed; Region: rdgC; PRK00321
891974009433	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
891974009434	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
891974009435	nucleotide binding site [chemical binding]; other site
891974009436	ethanolamine permease; Region: 2A0305; TIGR00908
891974009437	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
891974009438	active site
891974009439	substrate binding site [chemical binding]; other site
891974009440	Phosphotransferase enzyme family; Region: APH; pfam01636
891974009441	ATP binding site [chemical binding]; other site
891974009442	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
891974009443	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
891974009444	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
891974009445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974009446	TolA C-terminal; Region: TolA; pfam06519
891974009447	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
891974009448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
891974009449	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
891974009450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009451	Walker B; other site
891974009452	D-loop; other site
891974009453	H-loop/switch region; other site
891974009454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009455	Walker A/P-loop; other site
891974009456	ATP binding site [chemical binding]; other site
891974009457	Q-loop/lid; other site
891974009458	exonuclease subunit SbcD; Provisional; Region: PRK10966
891974009459	exonuclease SbcD; Region: sbcd; TIGR00619
891974009460	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
891974009461	transcriptional regulator PhoB; Provisional; Region: PRK10161
891974009462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974009463	active site
891974009464	phosphorylation site [posttranslational modification]
891974009465	intermolecular recognition site; other site
891974009466	dimerization interface [polypeptide binding]; other site
891974009467	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974009468	DNA binding site [nucleotide binding]
891974009469	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
891974009470	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
891974009471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974009472	putative active site [active]
891974009473	heme pocket [chemical binding]; other site
891974009474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974009475	dimer interface [polypeptide binding]; other site
891974009476	phosphorylation site [posttranslational modification]
891974009477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974009478	ATP binding site [chemical binding]; other site
891974009479	Mg2+ binding site [ion binding]; other site
891974009480	G-X-G motif; other site
891974009481	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974009482	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974009483	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
891974009484	substrate binding site [chemical binding]; other site
891974009485	zinc-binding site [ion binding]; other site
891974009486	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
891974009487	Spore germination protein; Region: Spore_permease; cl17796
891974009488	putative proline-specific permease; Provisional; Region: proY; PRK10580
891974009489	Acyltransferase family; Region: Acyl_transf_3; cl19154
891974009490	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
891974009491	Protein of unknown function, DUF479; Region: DUF479; cl01203
891974009492	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
891974009493	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
891974009494	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
891974009495	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
891974009496	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
891974009497	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
891974009498	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
891974009499	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
891974009500	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
891974009501	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
891974009502	Protein export membrane protein; Region: SecD_SecF; pfam02355
891974009503	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
891974009504	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
891974009505	BON domain; Region: BON; pfam04972
891974009506	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974009507	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
891974009508	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
891974009509	ATP cone domain; Region: ATP-cone; pfam03477
891974009510	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
891974009511	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
891974009512	catalytic motif [active]
891974009513	Zn binding site [ion binding]; other site
891974009514	RibD C-terminal domain; Region: RibD_C; cl17279
891974009515	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
891974009516	homopentamer interface [polypeptide binding]; other site
891974009517	active site
891974009518	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
891974009519	thiamine monophosphate kinase; Provisional; Region: PRK05731
891974009520	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
891974009521	ATP binding site [chemical binding]; other site
891974009522	dimerization interface [polypeptide binding]; other site
891974009523	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
891974009524	tetramer interfaces [polypeptide binding]; other site
891974009525	binuclear metal-binding site [ion binding]; other site
891974009526	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
891974009527	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
891974009528	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974009529	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974009530	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974009531	catalytic residues [active]
891974009532	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974009533	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974009534	Synaptic Site I dimer interface [polypeptide binding]; other site
891974009535	DNA binding site [nucleotide binding]
891974009536	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974009537	DNA-binding interface [nucleotide binding]; DNA binding site
891974009538	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974009539	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974009540	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974009541	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974009542	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974009543	catalytic residues [active]
891974009544	catalytic nucleophile [active]
891974009545	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974009546	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974009547	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974009548	Synaptic Site I dimer interface [polypeptide binding]; other site
891974009549	DNA binding site [nucleotide binding]
891974009550	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974009551	DNA-binding interface [nucleotide binding]; DNA binding site
891974009552	glycine dehydrogenase; Provisional; Region: PRK05367
891974009553	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
891974009554	tetramer interface [polypeptide binding]; other site
891974009555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009556	catalytic residue [active]
891974009557	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
891974009558	tetramer interface [polypeptide binding]; other site
891974009559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009560	catalytic residue [active]
891974009561	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
891974009562	lipoyl attachment site [posttranslational modification]; other site
891974009563	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
891974009564	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
891974009565	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
891974009566	oxidoreductase; Provisional; Region: PRK08013
891974009567	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
891974009568	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
891974009569	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
891974009570	proline aminopeptidase P II; Provisional; Region: PRK10879
891974009571	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
891974009572	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
891974009573	active site
891974009574	hypothetical protein; Reviewed; Region: PRK01736
891974009575	Z-ring-associated protein; Provisional; Region: PRK10972
891974009576	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
891974009577	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
891974009578	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
891974009579	ligand binding site [chemical binding]; other site
891974009580	NAD binding site [chemical binding]; other site
891974009581	tetramer interface [polypeptide binding]; other site
891974009582	catalytic site [active]
891974009583	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
891974009584	L-serine binding site [chemical binding]; other site
891974009585	ACT domain interface; other site
891974009586	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
891974009587	tetramer (dimer of dimers) interface [polypeptide binding]; other site
891974009588	active site
891974009589	dimer interface [polypeptide binding]; other site
891974009590	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
891974009591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009592	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
891974009593	putative dimerization interface [polypeptide binding]; other site
891974009594	oxidative stress defense protein; Provisional; Region: PRK11087
891974009595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009596	putative substrate translocation pore; other site
891974009597	D-galactonate transporter; Region: 2A0114; TIGR00893
891974009598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009599	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
891974009600	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
891974009601	arginine exporter protein; Provisional; Region: PRK09304
891974009602	mechanosensitive channel MscS; Provisional; Region: PRK10334
891974009603	Mechanosensitive ion channel; Region: MS_channel; pfam00924
891974009604	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
891974009605	active site
891974009606	intersubunit interface [polypeptide binding]; other site
891974009607	zinc binding site [ion binding]; other site
891974009608	Na+ binding site [ion binding]; other site
891974009609	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
891974009610	substrate binding site [chemical binding]; other site
891974009611	hinge regions; other site
891974009612	ADP binding site [chemical binding]; other site
891974009613	catalytic site [active]
891974009614	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
891974009615	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
891974009616	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
891974009617	transketolase; Reviewed; Region: PRK12753
891974009618	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
891974009619	TPP-binding site [chemical binding]; other site
891974009620	dimer interface [polypeptide binding]; other site
891974009621	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
891974009622	PYR/PP interface [polypeptide binding]; other site
891974009623	dimer interface [polypeptide binding]; other site
891974009624	TPP binding site [chemical binding]; other site
891974009625	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
891974009626	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
891974009627	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974009628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009629	Walker A/P-loop; other site
891974009630	ATP binding site [chemical binding]; other site
891974009631	Q-loop/lid; other site
891974009632	ABC transporter signature motif; other site
891974009633	agmatinase; Provisional; Region: PRK02190
891974009634	active site
891974009635	metal binding site [ion binding]; metal-binding site
891974009636	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
891974009637	putative active site [active]
891974009638	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
891974009639	Outer membrane efflux protein; Region: OEP; pfam02321
891974009640	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
891974009641	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009642	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009643	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009644	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009645	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
891974009646	arginine decarboxylase; Provisional; Region: PRK05354
891974009647	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974009648	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974009649	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
891974009650	S-adenosylmethionine synthetase; Validated; Region: PRK05250
891974009651	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
891974009652	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
891974009653	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
891974009654	Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092
891974009655	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
891974009656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009657	putative substrate translocation pore; other site
891974009658	hypothetical protein; Provisional; Region: PRK04860
891974009659	Endonuclease I; Region: Endonuclease_1; cl01003
891974009660	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
891974009661	glutathione synthetase; Provisional; Region: PRK05246
891974009662	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
891974009663	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
891974009664	hypothetical protein; Validated; Region: PRK00228
891974009665	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
891974009666	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
891974009667	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
891974009668	Walker A motif; other site
891974009669	ATP binding site [chemical binding]; other site
891974009670	Walker B motif; other site
891974009671	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
891974009672	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
891974009673	catalytic residue [active]
891974009674	YGGT family; Region: YGGT; pfam02325
891974009675	Predicted integral membrane protein [Function unknown]; Region: COG0762
891974009676	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
891974009677	active site
891974009678	dimerization interface [polypeptide binding]; other site
891974009679	HemN family oxidoreductase; Provisional; Region: PRK05660
891974009680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
891974009681	FeS/SAM binding site; other site
891974009682	HemN C-terminal domain; Region: HemN_C; pfam06969
891974009683	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009684	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009685	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974009686	hypothetical protein; Provisional; Region: PRK10626
891974009687	hypothetical protein; Provisional; Region: PRK11702
891974009688	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
891974009689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974009690	S-adenosylmethionine binding site [chemical binding]; other site
891974009691	adenine DNA glycosylase; Provisional; Region: PRK10880
891974009692	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
891974009693	minor groove reading motif; other site
891974009694	helix-hairpin-helix signature motif; other site
891974009695	substrate binding pocket [chemical binding]; other site
891974009696	active site
891974009697	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
891974009698	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
891974009699	DNA binding and oxoG recognition site [nucleotide binding]
891974009700	oxidative damage protection protein; Provisional; Region: PRK05408
891974009701	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
891974009702	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
891974009703	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974009704	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974009705	catalytic residue [active]
891974009706	ornithine decarboxylase; Provisional; Region: PRK13578
891974009707	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
891974009708	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
891974009709	homodimer interface [polypeptide binding]; other site
891974009710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009711	catalytic residue [active]
891974009712	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
891974009713	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
891974009714	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
891974009715	NADP binding site [chemical binding]; other site
891974009716	dimer interface [polypeptide binding]; other site
891974009717	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
891974009718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009719	Walker B; other site
891974009720	D-loop; other site
891974009721	H-loop/switch region; other site
891974009722	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
891974009723	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
891974009724	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
891974009725	intersubunit interface [polypeptide binding]; other site
891974009726	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
891974009727	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
891974009728	N-terminal plug; other site
891974009729	ligand-binding site [chemical binding]; other site
891974009730	Rdx family; Region: Rdx; cl01407
891974009731	Predicted transcriptional regulators [Transcription]; Region: COG1695
891974009732	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
891974009733	FAD binding pocket [chemical binding]; other site
891974009734	FAD binding motif [chemical binding]; other site
891974009735	phosphate binding motif [ion binding]; other site
891974009736	NAD binding pocket [chemical binding]; other site
891974009737	chaperone protein DnaJ; Provisional; Region: PRK10767
891974009738	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
891974009739	HSP70 interaction site [polypeptide binding]; other site
891974009740	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
891974009741	substrate binding site [polypeptide binding]; other site
891974009742	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
891974009743	Zn binding sites [ion binding]; other site
891974009744	dimer interface [polypeptide binding]; other site
891974009745	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
891974009746	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974009747	nucleotide binding site [chemical binding]; other site
891974009748	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
891974009749	metabolite-proton symporter; Region: 2A0106; TIGR00883
891974009750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009751	putative substrate translocation pore; other site
891974009752	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
891974009753	MPT binding site; other site
891974009754	trimer interface [polypeptide binding]; other site
891974009755	transaldolase-like protein; Provisional; Region: PTZ00411
891974009756	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
891974009757	active site
891974009758	dimer interface [polypeptide binding]; other site
891974009759	catalytic residue [active]
891974009760	Protein of unknown function (DUF328); Region: DUF328; cl01143
891974009761	hypothetical protein; Validated; Region: PRK02101
891974009762	threonine synthase; Validated; Region: PRK09225
891974009763	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974009764	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974009765	catalytic residue [active]
891974009766	homoserine kinase; Provisional; Region: PRK01212
891974009767	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
891974009768	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
891974009769	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
891974009770	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
891974009771	putative catalytic residues [active]
891974009772	putative nucleotide binding site [chemical binding]; other site
891974009773	putative aspartate binding site [chemical binding]; other site
891974009774	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
891974009775	dimer interface [polypeptide binding]; other site
891974009776	putative threonine allosteric regulatory site; other site
891974009777	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
891974009778	putative threonine allosteric regulatory site; other site
891974009779	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
891974009780	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
891974009781	putative RNA methyltransferase; Provisional; Region: PRK10433
891974009782	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
891974009783	two-component response regulator; Provisional; Region: PRK11173
891974009784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974009785	active site
891974009786	phosphorylation site [posttranslational modification]
891974009787	intermolecular recognition site; other site
891974009788	dimerization interface [polypeptide binding]; other site
891974009789	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974009790	DNA binding site [nucleotide binding]
891974009791	hypothetical protein; Provisional; Region: PRK10756
891974009792	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
891974009793	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974009794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974009795	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
891974009796	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974009797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974009798	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
891974009799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009800	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
891974009801	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974009802	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
891974009803	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974009804	putative ligand binding site [chemical binding]; other site
891974009805	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
891974009806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974009807	Coenzyme A binding pocket [chemical binding]; other site
891974009808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974009809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974009810	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
891974009811	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974009812	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
891974009813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974009814	Walker A/P-loop; other site
891974009815	ATP binding site [chemical binding]; other site
891974009816	Q-loop/lid; other site
891974009817	ABC transporter signature motif; other site
891974009818	Walker B; other site
891974009819	D-loop; other site
891974009820	H-loop/switch region; other site
891974009821	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151
891974009822	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974009823	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009824	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
891974009825	putative effector binding pocket; other site
891974009826	dimerization interface [polypeptide binding]; other site
891974009827	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
891974009828	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974009829	dimer interface [polypeptide binding]; other site
891974009830	substrate binding pocket (H-site) [chemical binding]; other site
891974009831	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
891974009832	N-terminal domain interface [polypeptide binding]; other site
891974009833	putative substrate binding pocket (H-site) [chemical binding]; other site
891974009834	putative hydrolase; Provisional; Region: PRK11460
891974009835	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
891974009836	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
891974009837	chromosome condensation membrane protein; Provisional; Region: PRK14196
891974009838	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
891974009839	HemN C-terminal domain; Region: HemN_C; pfam06969
891974009840	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
891974009841	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
891974009842	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
891974009843	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
891974009844	active site
891974009845	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164
891974009846	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974009847	active site turn [active]
891974009848	phosphorylation site [posttranslational modification]
891974009849	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
891974009850	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
891974009851	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
891974009852	hypothetical protein; Provisional; Region: PRK11469
891974009853	Domain of unknown function DUF; Region: DUF204; pfam02659
891974009854	Domain of unknown function DUF; Region: DUF204; pfam02659
891974009855	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
891974009856	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
891974009857	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
891974009858	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
891974009859	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
891974009860	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
891974009861	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
891974009862	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974009863	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
891974009864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009865	homodimer interface [polypeptide binding]; other site
891974009866	catalytic residue [active]
891974009867	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
891974009868	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
891974009869	dimer interface [polypeptide binding]; other site
891974009870	N-terminal domain interface [polypeptide binding]; other site
891974009871	substrate binding pocket (H-site) [chemical binding]; other site
891974009872	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
891974009873	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
891974009874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974009875	NAD(P) binding site [chemical binding]; other site
891974009876	active site
891974009877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974009878	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974009879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009880	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974009881	dimerization interface [polypeptide binding]; other site
891974009882	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974009883	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974009884	inner membrane protein YhjD; Region: TIGR00766
891974009885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009886	putative substrate translocation pore; other site
891974009887	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974009888	ketol-acid reductoisomerase; Validated; Region: PRK05225
891974009889	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
891974009890	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
891974009891	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009892	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
891974009893	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
891974009894	putative dimerization interface [polypeptide binding]; other site
891974009895	threonine dehydratase; Reviewed; Region: PRK09224
891974009896	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
891974009897	tetramer interface [polypeptide binding]; other site
891974009898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974009899	catalytic residue [active]
891974009900	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
891974009901	putative Ile/Val binding site [chemical binding]; other site
891974009902	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
891974009903	putative Ile/Val binding site [chemical binding]; other site
891974009904	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
891974009905	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
891974009906	homodimer interface [polypeptide binding]; other site
891974009907	substrate-cofactor binding pocket; other site
891974009908	catalytic residue [active]
891974009909	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
891974009910	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
891974009911	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
891974009912	PYR/PP interface [polypeptide binding]; other site
891974009913	dimer interface [polypeptide binding]; other site
891974009914	TPP binding site [chemical binding]; other site
891974009915	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974009916	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
891974009917	TPP-binding site [chemical binding]; other site
891974009918	dimer interface [polypeptide binding]; other site
891974009919	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
891974009920	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
891974009921	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
891974009922	hypothetical protein; Provisional; Region: PRK11027
891974009923	transcriptional regulator HdfR; Provisional; Region: PRK03601
891974009924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974009925	LysR substrate binding domain; Region: LysR_substrate; pfam03466
891974009926	dimerization interface [polypeptide binding]; other site
891974009927	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
891974009928	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
891974009929	trimer interface [polypeptide binding]; other site
891974009930	putative metal binding site [ion binding]; other site
891974009931	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
891974009932	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
891974009933	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
891974009934	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
891974009935	shikimate binding site; other site
891974009936	NAD(P) binding site [chemical binding]; other site
891974009937	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
891974009938	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
891974009939	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
891974009940	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
891974009941	hypothetical protein; Validated; Region: PRK03430
891974009942	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
891974009943	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
891974009944	active site
891974009945	catalytic residues [active]
891974009946	metal binding site [ion binding]; metal-binding site
891974009947	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
891974009948	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
891974009949	putative active site [active]
891974009950	substrate binding site [chemical binding]; other site
891974009951	putative cosubstrate binding site; other site
891974009952	catalytic site [active]
891974009953	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
891974009954	substrate binding site [chemical binding]; other site
891974009955	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
891974009956	putative RNA binding site [nucleotide binding]; other site
891974009957	16S rRNA methyltransferase B; Provisional; Region: PRK10901
891974009958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974009959	S-adenosylmethionine binding site [chemical binding]; other site
891974009960	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
891974009961	TrkA-N domain; Region: TrkA_N; pfam02254
891974009962	TrkA-C domain; Region: TrkA_C; pfam02080
891974009963	TrkA-N domain; Region: TrkA_N; pfam02254
891974009964	TrkA-C domain; Region: TrkA_C; pfam02080
891974009965	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
891974009966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974009967	Transposase; Region: HTH_Tnp_1; cl17663
891974009968	Integrase core domain; Region: rve; pfam00665
891974009969	Integrase core domain; Region: rve_3; pfam13683
891974009970	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
891974009971	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
891974009972	DNA binding residues [nucleotide binding]
891974009973	dimer interface [polypeptide binding]; other site
891974009974	metal binding site [ion binding]; metal-binding site
891974009975	hypothetical protein; Provisional; Region: PRK10203
891974009976	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
891974009977	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
891974009978	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
891974009979	alphaNTD homodimer interface [polypeptide binding]; other site
891974009980	alphaNTD - beta interaction site [polypeptide binding]; other site
891974009981	alphaNTD - beta' interaction site [polypeptide binding]; other site
891974009982	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
891974009983	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
891974009984	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
891974009985	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974009986	RNA binding surface [nucleotide binding]; other site
891974009987	30S ribosomal protein S11; Validated; Region: PRK05309
891974009988	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
891974009989	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
891974009990	SecY translocase; Region: SecY; pfam00344
891974009991	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
891974009992	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
891974009993	23S rRNA binding site [nucleotide binding]; other site
891974009994	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
891974009995	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
891974009996	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
891974009997	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
891974009998	23S rRNA interface [nucleotide binding]; other site
891974009999	5S rRNA interface [nucleotide binding]; other site
891974010000	L27 interface [polypeptide binding]; other site
891974010001	L5 interface [polypeptide binding]; other site
891974010002	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
891974010003	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
891974010004	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
891974010005	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
891974010006	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
891974010007	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
891974010008	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
891974010009	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
891974010010	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
891974010011	RNA binding site [nucleotide binding]; other site
891974010012	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
891974010013	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
891974010014	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
891974010015	23S rRNA interface [nucleotide binding]; other site
891974010016	putative translocon interaction site; other site
891974010017	signal recognition particle (SRP54) interaction site; other site
891974010018	L23 interface [polypeptide binding]; other site
891974010019	trigger factor interaction site; other site
891974010020	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
891974010021	23S rRNA interface [nucleotide binding]; other site
891974010022	5S rRNA interface [nucleotide binding]; other site
891974010023	putative antibiotic binding site [chemical binding]; other site
891974010024	L25 interface [polypeptide binding]; other site
891974010025	L27 interface [polypeptide binding]; other site
891974010026	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
891974010027	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
891974010028	G-X-X-G motif; other site
891974010029	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
891974010030	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
891974010031	protein-rRNA interface [nucleotide binding]; other site
891974010032	putative translocon binding site; other site
891974010033	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
891974010034	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
891974010035	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
891974010036	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
891974010037	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
891974010038	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
891974010039	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
891974010040	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
891974010041	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
891974010042	Ferritin-like domain; Region: Ferritin; pfam00210
891974010043	heme binding site [chemical binding]; other site
891974010044	ferroxidase pore; other site
891974010045	ferroxidase diiron center [ion binding]; other site
891974010046	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
891974010047	elongation factor Tu; Reviewed; Region: PRK00049
891974010048	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
891974010049	G1 box; other site
891974010050	GEF interaction site [polypeptide binding]; other site
891974010051	GTP/Mg2+ binding site [chemical binding]; other site
891974010052	Switch I region; other site
891974010053	G2 box; other site
891974010054	G3 box; other site
891974010055	Switch II region; other site
891974010056	G4 box; other site
891974010057	G5 box; other site
891974010058	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
891974010059	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
891974010060	Antibiotic Binding Site [chemical binding]; other site
891974010061	elongation factor G; Reviewed; Region: PRK00007
891974010062	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
891974010063	G1 box; other site
891974010064	putative GEF interaction site [polypeptide binding]; other site
891974010065	GTP/Mg2+ binding site [chemical binding]; other site
891974010066	Switch I region; other site
891974010067	G2 box; other site
891974010068	G3 box; other site
891974010069	Switch II region; other site
891974010070	G4 box; other site
891974010071	G5 box; other site
891974010072	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
891974010073	Elongation Factor G, domain II; Region: EFG_II; pfam14492
891974010074	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
891974010075	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
891974010076	30S ribosomal protein S7; Validated; Region: PRK05302
891974010077	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
891974010078	S17 interaction site [polypeptide binding]; other site
891974010079	S8 interaction site; other site
891974010080	16S rRNA interaction site [nucleotide binding]; other site
891974010081	streptomycin interaction site [chemical binding]; other site
891974010082	23S rRNA interaction site [nucleotide binding]; other site
891974010083	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
891974010084	DsrH like protein; Region: DsrH; cl17347
891974010085	sulfur relay protein TusC; Validated; Region: PRK00211
891974010086	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
891974010087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
891974010088	YheO-like PAS domain; Region: PAS_6; pfam08348
891974010089	HTH domain; Region: HTH_22; pfam13309
891974010090	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
891974010091	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
891974010092	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
891974010093	SlyX; Region: SlyX; cl01090
891974010094	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
891974010095	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
891974010096	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
891974010097	TrkA-N domain; Region: TrkA_N; pfam02254
891974010098	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
891974010099	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
891974010100	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974010101	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
891974010102	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
891974010103	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974010104	ABC transporter; Region: ABC_tran_2; pfam12848
891974010105	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
891974010106	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
891974010107	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
891974010108	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
891974010109	active site
891974010110	iron coordination sites [ion binding]; other site
891974010111	substrate binding pocket [chemical binding]; other site
891974010112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974010113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974010114	dimer interface [polypeptide binding]; other site
891974010115	conserved gate region; other site
891974010116	ABC-ATPase subunit interface; other site
891974010117	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
891974010118	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
891974010119	Walker A/P-loop; other site
891974010120	ATP binding site [chemical binding]; other site
891974010121	Q-loop/lid; other site
891974010122	ABC transporter signature motif; other site
891974010123	Walker B; other site
891974010124	D-loop; other site
891974010125	H-loop/switch region; other site
891974010126	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
891974010127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974010128	substrate binding pocket [chemical binding]; other site
891974010129	membrane-bound complex binding site; other site
891974010130	hinge residues; other site
891974010131	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974010132	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974010133	DNA binding site [nucleotide binding]
891974010134	domain linker motif; other site
891974010135	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
891974010136	dimerization interface [polypeptide binding]; other site
891974010137	ligand binding site [chemical binding]; other site
891974010138	LysE type translocator; Region: LysE; cl00565
891974010139	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974010140	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974010141	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974010142	hypothetical protein; Provisional; Region: PRK04966
891974010143	phosphoribulokinase; Provisional; Region: PRK15453
891974010144	active site
891974010145	OsmC-like protein; Region: OsmC; cl00767
891974010146	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
891974010147	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
891974010148	ligand binding site [chemical binding]; other site
891974010149	flexible hinge region; other site
891974010150	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
891974010151	putative switch regulator; other site
891974010152	non-specific DNA interactions [nucleotide binding]; other site
891974010153	DNA binding site [nucleotide binding]
891974010154	sequence specific DNA binding site [nucleotide binding]; other site
891974010155	putative cAMP binding site [chemical binding]; other site
891974010156	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
891974010157	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
891974010158	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
891974010159	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
891974010160	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
891974010161	inhibitor-cofactor binding pocket; inhibition site
891974010162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974010163	catalytic residue [active]
891974010164	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
891974010165	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
891974010166	glutamine binding [chemical binding]; other site
891974010167	catalytic triad [active]
891974010168	Fic/DOC family; Region: Fic; cl00960
891974010169	Fic/DOC family; Region: Fic; cl00960
891974010170	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
891974010171	substrate binding site [chemical binding]; other site
891974010172	putative transporter; Provisional; Region: PRK03699
891974010173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010174	putative substrate translocation pore; other site
891974010175	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
891974010176	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
891974010177	active site
891974010178	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974010179	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
891974010180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974010181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974010182	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
891974010183	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
891974010184	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
891974010185	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
891974010186	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
891974010187	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
891974010188	siroheme synthase; Provisional; Region: cysG; PRK10637
891974010189	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
891974010190	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
891974010191	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
891974010192	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
891974010193	active site
891974010194	SAM binding site [chemical binding]; other site
891974010195	homodimer interface [polypeptide binding]; other site
891974010196	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
891974010197	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
891974010198	active site
891974010199	HIGH motif; other site
891974010200	dimer interface [polypeptide binding]; other site
891974010201	KMSKS motif; other site
891974010202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974010203	motif II; other site
891974010204	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
891974010205	substrate binding site [chemical binding]; other site
891974010206	hexamer interface [polypeptide binding]; other site
891974010207	metal binding site [ion binding]; metal-binding site
891974010208	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
891974010209	hypothetical protein; Reviewed; Region: PRK11901
891974010210	Sporulation related domain; Region: SPOR; pfam05036
891974010211	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
891974010212	active site
891974010213	dimer interface [polypeptide binding]; other site
891974010214	metal binding site [ion binding]; metal-binding site
891974010215	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
891974010216	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
891974010217	ADP binding site [chemical binding]; other site
891974010218	magnesium binding site [ion binding]; other site
891974010219	putative shikimate binding site; other site
891974010220	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
891974010221	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
891974010222	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
891974010223	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
891974010224	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
891974010225	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
891974010226	Transglycosylase; Region: Transgly; pfam00912
891974010227	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974010228	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
891974010229	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
891974010230	ADP-ribose binding site [chemical binding]; other site
891974010231	dimer interface [polypeptide binding]; other site
891974010232	active site
891974010233	nudix motif; other site
891974010234	metal binding site [ion binding]; metal-binding site
891974010235	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
891974010236	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
891974010237	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974010238	RNA binding surface [nucleotide binding]; other site
891974010239	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
891974010240	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
891974010241	dimerization interface [polypeptide binding]; other site
891974010242	domain crossover interface; other site
891974010243	redox-dependent activation switch; other site
891974010244	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
891974010245	active site
891974010246	nucleotide-binding site [chemical binding]; other site
891974010247	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
891974010248	metal-binding site [ion binding]
891974010249	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
891974010250	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
891974010251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974010252	dimerization interface [polypeptide binding]; other site
891974010253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974010254	dimer interface [polypeptide binding]; other site
891974010255	phosphorylation site [posttranslational modification]
891974010256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974010257	ATP binding site [chemical binding]; other site
891974010258	Mg2+ binding site [ion binding]; other site
891974010259	G-X-G motif; other site
891974010260	osmolarity response regulator; Provisional; Region: ompR; PRK09468
891974010261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974010262	active site
891974010263	phosphorylation site [posttranslational modification]
891974010264	intermolecular recognition site; other site
891974010265	dimerization interface [polypeptide binding]; other site
891974010266	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
891974010267	DNA binding site [nucleotide binding]
891974010268	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
891974010269	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
891974010270	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
891974010271	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
891974010272	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
891974010273	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
891974010274	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
891974010275	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
891974010276	RNA binding site [nucleotide binding]; other site
891974010277	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
891974010278	active site
891974010279	homodimer interface [polypeptide binding]; other site
891974010280	catalytic site [active]
891974010281	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
891974010282	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
891974010283	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974010284	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
891974010285	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
891974010286	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974010287	active site
891974010288	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
891974010289	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
891974010290	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
891974010291	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
891974010292	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
891974010293	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974010294	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974010295	Carbohydrate phosphorylase; Region: Phosphorylase; pfam00343
891974010296	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974010297	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
891974010298	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
891974010299	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974010300	intramembrane serine protease GlpG; Provisional; Region: PRK10907
891974010301	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
891974010302	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
891974010303	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
891974010304	active site residue [active]
891974010305	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
891974010306	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
891974010307	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
891974010308	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
891974010309	Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092
891974010310	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
891974010311	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
891974010312	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974010313	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974010314	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974010315	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
891974010316	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
891974010317	PYR/PP interface [polypeptide binding]; other site
891974010318	dimer interface [polypeptide binding]; other site
891974010319	TPP binding site [chemical binding]; other site
891974010320	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974010321	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
891974010322	TPP-binding site; other site
891974010323	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
891974010324	substrate binding site [chemical binding]; other site
891974010325	ATP binding site [chemical binding]; other site
891974010326	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
891974010327	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974010328	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974010329	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974010330	putative active site [active]
891974010331	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974010332	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974010333	catalytic residues [active]
891974010334	catalytic nucleophile [active]
891974010335	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974010336	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974010337	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974010338	Synaptic Site I dimer interface [polypeptide binding]; other site
891974010339	DNA binding site [nucleotide binding]
891974010340	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974010341	DNA-binding interface [nucleotide binding]; DNA binding site
891974010342	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974010343	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
891974010344	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974010345	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974010346	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
891974010347	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
891974010348	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
891974010349	Domain of unknown function DUF29; Region: DUF29; pfam01724
891974010350	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
891974010351	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
891974010352	dimer interface [polypeptide binding]; other site
891974010353	ssDNA binding site [nucleotide binding]; other site
891974010354	tetramer (dimer of dimers) interface [polypeptide binding]; other site
891974010355	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
891974010356	DNA topoisomerase III; Provisional; Region: PRK07726
891974010357	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
891974010358	active site
891974010359	putative interdomain interaction site [polypeptide binding]; other site
891974010360	putative metal-binding site [ion binding]; other site
891974010361	putative nucleotide binding site [chemical binding]; other site
891974010362	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
891974010363	domain I; other site
891974010364	DNA binding groove [nucleotide binding]
891974010365	phosphate binding site [ion binding]; other site
891974010366	domain II; other site
891974010367	domain III; other site
891974010368	nucleotide binding site [chemical binding]; other site
891974010369	catalytic site [active]
891974010370	domain IV; other site
891974010371	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
891974010372	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
891974010373	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
891974010374	ParB-like nuclease domain; Region: ParBc; cl02129
891974010375	ParB-like nuclease domain; Region: ParBc; cl02129
891974010376	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
891974010377	replicative DNA helicase; Region: DnaB; TIGR00665
891974010378	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
891974010379	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
891974010380	Walker A motif; other site
891974010381	ATP binding site [chemical binding]; other site
891974010382	Walker B motif; other site
891974010383	DNA binding loops [nucleotide binding]
891974010384	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
891974010385	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
891974010386	P-loop; other site
891974010387	Magnesium ion binding site [ion binding]; other site
891974010388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974010389	non-specific DNA binding site [nucleotide binding]; other site
891974010390	salt bridge; other site
891974010391	sequence-specific DNA binding site [nucleotide binding]; other site
891974010392	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
891974010393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974010394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974010395	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974010396	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
891974010397	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
891974010398	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974010399	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974010400	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974010401	DNA binding site [nucleotide binding]
891974010402	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974010403	domain linker motif; other site
891974010404	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
891974010405	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
891974010406	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
891974010407	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
891974010408	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
891974010409	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974010410	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974010411	DNA binding site [nucleotide binding]
891974010412	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974010413	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974010414	putative S-transferase; Provisional; Region: PRK11752
891974010415	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
891974010416	C-terminal domain interface [polypeptide binding]; other site
891974010417	GSH binding site (G-site) [chemical binding]; other site
891974010418	dimer interface [polypeptide binding]; other site
891974010419	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
891974010420	dimer interface [polypeptide binding]; other site
891974010421	N-terminal domain interface [polypeptide binding]; other site
891974010422	active site
891974010423	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974010424	NAD(P) binding site [chemical binding]; other site
891974010425	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974010426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010428	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
891974010429	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974010430	active site
891974010431	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974010432	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
891974010433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974010434	active site
891974010435	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
891974010436	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
891974010437	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974010438	dimer interface [polypeptide binding]; other site
891974010439	putative CheW interface [polypeptide binding]; other site
891974010440	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
891974010441	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974010442	dimerization interface [polypeptide binding]; other site
891974010443	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
891974010444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974010445	active site
891974010446	phosphorylation site [posttranslational modification]
891974010447	intermolecular recognition site; other site
891974010448	dimerization interface [polypeptide binding]; other site
891974010449	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
891974010450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974010451	ATP-binding site [chemical binding]; other site
891974010452	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
891974010453	putative RNA binding site [nucleotide binding]; other site
891974010454	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
891974010455	ATP binding site [chemical binding]; other site
891974010456	Mg++ binding site [ion binding]; other site
891974010457	motif III; other site
891974010458	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974010459	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010460	active site
891974010461	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010462	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974010463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010465	dimerization interface [polypeptide binding]; other site
891974010466	putative cyanate transporter; Provisional; Region: cynX; PRK09705
891974010467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010468	putative substrate translocation pore; other site
891974010469	L-lactate permease; Region: Lactate_perm; cl00701
891974010470	L-lactate permease; Region: Lactate_perm; cl00701
891974010471	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
891974010472	DNA-binding site [nucleotide binding]; DNA binding site
891974010473	FCD domain; Region: FCD; pfam07729
891974010474	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974010475	phosphate binding site [ion binding]; other site
891974010476	OsmC-like protein; Region: OsmC; cl00767
891974010477	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
891974010478	active site
891974010479	P-loop; other site
891974010480	phosphorylation site [posttranslational modification]
891974010481	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
891974010482	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
891974010483	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
891974010484	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
891974010485	active site
891974010486	methionine cluster; other site
891974010487	phosphorylation site [posttranslational modification]
891974010488	metal binding site [ion binding]; metal-binding site
891974010489	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
891974010490	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
891974010491	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
891974010492	tetramerization interface [polypeptide binding]; other site
891974010493	NAD(P) binding site [chemical binding]; other site
891974010494	catalytic residues [active]
891974010495	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
891974010496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010497	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
891974010498	dimerization interface [polypeptide binding]; other site
891974010499	substrate binding pocket [chemical binding]; other site
891974010500	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974010501	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974010502	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974010503	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974010504	DNA binding site [nucleotide binding]
891974010505	CAAX protease self-immunity; Region: Abi; pfam02517
891974010506	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
891974010507	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
891974010508	drug efflux system protein MdtG; Provisional; Region: PRK09874
891974010509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010510	putative substrate translocation pore; other site
891974010511	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
891974010512	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
891974010513	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
891974010514	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
891974010515	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
891974010516	Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681
891974010517	psiF repeat; Region: PsiF_repeat; pfam07769
891974010518	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
891974010519	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974010520	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
891974010521	putative ligand binding site [chemical binding]; other site
891974010522	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
891974010523	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974010524	Walker A/P-loop; other site
891974010525	ATP binding site [chemical binding]; other site
891974010526	Q-loop/lid; other site
891974010527	ABC transporter signature motif; other site
891974010528	Walker B; other site
891974010529	D-loop; other site
891974010530	H-loop/switch region; other site
891974010531	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
891974010532	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974010533	TM-ABC transporter signature motif; other site
891974010534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010535	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
891974010536	putative dimerization interface [polypeptide binding]; other site
891974010537	Helix-turn-helix domain; Region: HTH_28; pfam13518
891974010538	Winged helix-turn helix; Region: HTH_29; pfam13551
891974010539	Homeodomain-like domain; Region: HTH_32; pfam13565
891974010540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
891974010541	Integrase core domain; Region: rve; pfam00665
891974010542	Integrase core domain; Region: rve_3; pfam13683
891974010543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010544	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010545	dimerization interface [polypeptide binding]; other site
891974010546	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974010547	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974010548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974010549	Coenzyme A binding pocket [chemical binding]; other site
891974010550	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
891974010551	PYR/PP interface [polypeptide binding]; other site
891974010552	dimer interface [polypeptide binding]; other site
891974010553	tetramer interface [polypeptide binding]; other site
891974010554	TPP binding site [chemical binding]; other site
891974010555	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
891974010556	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
891974010557	TPP-binding site [chemical binding]; other site
891974010558	Transposase IS200 like; Region: Y1_Tnp; cl00848
891974010559	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974010560	CHASE4 domain; Region: CHASE4; cl01308
891974010561	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
891974010562	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974010563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
891974010564	DNA-binding site [nucleotide binding]; DNA binding site
891974010565	UTRA domain; Region: UTRA; pfam07702
891974010566	Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754
891974010567	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
891974010568	Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; cl01456
891974010569	Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; cl01456
891974010570	Phosphonate metabolizm protein PhnJ; Region: PhnJ; cl01457
891974010571	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
891974010572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974010573	Walker A/P-loop; other site
891974010574	ATP binding site [chemical binding]; other site
891974010575	Q-loop/lid; other site
891974010576	ABC transporter signature motif; other site
891974010577	Walker B; other site
891974010578	D-loop; other site
891974010579	H-loop/switch region; other site
891974010580	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
891974010581	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
891974010582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974010583	Walker A/P-loop; other site
891974010584	ATP binding site [chemical binding]; other site
891974010585	Q-loop/lid; other site
891974010586	ABC transporter signature motif; other site
891974010587	Walker B; other site
891974010588	D-loop; other site
891974010589	H-loop/switch region; other site
891974010590	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
891974010591	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010592	active site
891974010593	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
891974010594	active site
891974010595	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
891974010596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974010597	Walker A/P-loop; other site
891974010598	ATP binding site [chemical binding]; other site
891974010599	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
891974010600	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974010601	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974010603	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974010604	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010605	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
891974010606	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
891974010607	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
891974010608	DNA binding residues [nucleotide binding]
891974010609	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
891974010610	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
891974010611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974010612	Walker A/P-loop; other site
891974010613	ATP binding site [chemical binding]; other site
891974010614	Q-loop/lid; other site
891974010615	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
891974010616	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
891974010617	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
891974010618	P loop; other site
891974010619	GTP binding site [chemical binding]; other site
891974010620	ribonuclease E; Reviewed; Region: rne; PRK10811
891974010621	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
891974010622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974010623	S-adenosylmethionine binding site [chemical binding]; other site
891974010624	hypothetical protein; Provisional; Region: PRK10910
891974010625	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
891974010626	Predicted membrane protein [Function unknown]; Region: COG3714
891974010627	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
891974010628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
891974010629	metal-binding site [ion binding]
891974010630	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
891974010631	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
891974010632	CPxP  motif; other site
891974010633	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
891974010634	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
891974010635	hypothetical protein; Provisional; Region: PRK11615
891974010636	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974010638	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974010639	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974010642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010643	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974010644	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010646	putative substrate translocation pore; other site
891974010647	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974010648	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
891974010649	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
891974010650	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
891974010651	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
891974010652	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
891974010653	catalytic triad [active]
891974010654	conserved cis-peptide bond; other site
891974010655	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
891974010656	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010657	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974010658	dimerization interface [polypeptide binding]; other site
891974010659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974010660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974010662	NAD(P) binding site [chemical binding]; other site
891974010663	active site
891974010664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974010665	Nucleoside recognition; Region: Gate; pfam07670
891974010666	glutathione reductase; Validated; Region: PRK06116
891974010667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974010668	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
891974010669	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
891974010670	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
891974010671	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
891974010672	flagellar assembly protein H; Validated; Region: fliH; PRK06800
891974010673	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
891974010674	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
891974010675	active site
891974010676	Zn binding site [ion binding]; other site
891974010677	putative methyltransferase; Provisional; Region: PRK10742
891974010678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010679	proline/glycine betaine transporter; Provisional; Region: PRK10642
891974010680	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
891974010681	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
891974010682	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
891974010683	cystathionine beta-lyase; Provisional; Region: PRK08114
891974010684	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974010685	catalytic residue [active]
891974010686	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
891974010687	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974010688	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974010689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974010690	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
891974010691	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974010692	active site
891974010693	catalytic tetrad [active]
891974010694	FtsI repressor; Provisional; Region: PRK10883
891974010695	Cupredoxin superfamily; Region: Cupredoxin; cl19115
891974010696	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
891974010697	Domain 1 interface [polypeptide binding]; other site
891974010698	Domain 3 interface [polypeptide binding]; other site
891974010699	Cupredoxin superfamily; Region: Cupredoxin; cl19115
891974010700	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
891974010701	putative acyl-acceptor binding pocket; other site
891974010702	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
891974010703	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
891974010704	CAP-like domain; other site
891974010705	active site
891974010706	primary dimer interface [polypeptide binding]; other site
891974010707	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
891974010708	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
891974010709	HTH domain; Region: HTH_11; pfam08279
891974010710	Mga helix-turn-helix domain; Region: Mga; pfam05043
891974010711	PRD domain; Region: PRD; pfam00874
891974010712	PRD domain; Region: PRD; pfam00874
891974010713	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
891974010714	active site
891974010715	P-loop; other site
891974010716	phosphorylation site [posttranslational modification]
891974010717	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
891974010718	active site
891974010719	phosphorylation site [posttranslational modification]
891974010720	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
891974010721	active site
891974010722	P-loop; other site
891974010723	phosphorylation site [posttranslational modification]
891974010724	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
891974010725	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
891974010726	intersubunit interface [polypeptide binding]; other site
891974010727	active site
891974010728	zinc binding site [ion binding]; other site
891974010729	Na+ binding site [ion binding]; other site
891974010730	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
891974010731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974010732	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
891974010733	substrate binding pocket [chemical binding]; other site
891974010734	membrane-bound complex binding site; other site
891974010735	hinge residues; other site
891974010736	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
891974010737	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
891974010738	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010739	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010740	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010741	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010742	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010743	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010744	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
891974010745	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
891974010746	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
891974010747	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
891974010748	ligand binding site [chemical binding]; other site
891974010749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010750	putative substrate translocation pore; other site
891974010751	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
891974010752	HAMP domain; Region: HAMP; pfam00672
891974010753	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
891974010754	dimer interface [polypeptide binding]; other site
891974010755	putative CheW interface [polypeptide binding]; other site
891974010756	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
891974010757	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
891974010758	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
891974010759	active site
891974010760	catalytic site [active]
891974010761	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
891974010762	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
891974010763	active site
891974010764	catalytic site [active]
891974010765	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
891974010766	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
891974010767	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
891974010768	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
891974010769	catalytic site [active]
891974010770	active site
891974010771	CsbD-like; Region: CsbD; cl17424
891974010772	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974010774	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974010775	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010776	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
891974010777	Na binding site [ion binding]; other site
891974010778	Predicted membrane protein [Function unknown]; Region: COG3162
891974010779	acetyl-CoA synthetase; Provisional; Region: PRK00174
891974010780	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
891974010781	active site
891974010782	CoA binding site [chemical binding]; other site
891974010783	acyl-activating enzyme (AAE) consensus motif; other site
891974010784	AMP binding site [chemical binding]; other site
891974010785	acetate binding site [chemical binding]; other site
891974010786	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
891974010787	YcfA-like protein; Region: YcfA; pfam07927
891974010788	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
891974010789	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
891974010790	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
891974010791	putative active site [active]
891974010792	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
891974010793	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974010794	active site turn [active]
891974010795	phosphorylation site [posttranslational modification]
891974010796	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974010797	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974010798	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
891974010799	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
891974010800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974010801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974010802	putative active site [active]
891974010803	PAS fold; Region: PAS_3; pfam08447
891974010804	heme pocket [chemical binding]; other site
891974010805	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974010806	metal binding site [ion binding]; metal-binding site
891974010807	active site
891974010808	I-site; other site
891974010809	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
891974010810	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010811	active site
891974010812	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010813	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
891974010814	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974010816	H+ Antiporter protein; Region: 2A0121; TIGR00900
891974010817	putative substrate translocation pore; other site
891974010818	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
891974010819	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974010820	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
891974010821	Trehalase; Region: Trehalase; cl17346
891974010822	Trehalase; Region: Trehalase; cl17346
891974010823	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
891974010824	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
891974010825	NADP binding site [chemical binding]; other site
891974010826	Predicted transcriptional regulators [Transcription]; Region: COG1733
891974010827	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
891974010828	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
891974010829	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
891974010830	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
891974010831	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
891974010832	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
891974010833	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974010834	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
891974010835	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
891974010836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974010837	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974010838	dimerization interface [polypeptide binding]; other site
891974010839	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
891974010840	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
891974010841	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
891974010842	active site
891974010843	Riboflavin kinase; Region: Flavokinase; smart00904
891974010844	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
891974010845	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
891974010846	active site
891974010847	HIGH motif; other site
891974010848	KMSKS motif; other site
891974010849	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
891974010850	tRNA binding surface [nucleotide binding]; other site
891974010851	anticodon binding site; other site
891974010852	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
891974010853	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
891974010854	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
891974010855	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
891974010856	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
891974010857	Fe-S cluster binding site [ion binding]; other site
891974010858	substrate binding site [chemical binding]; other site
891974010859	catalytic site [active]
891974010860	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
891974010861	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
891974010862	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
891974010863	carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368
891974010864	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
891974010865	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
891974010866	catalytic site [active]
891974010867	subunit interface [polypeptide binding]; other site
891974010868	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
891974010869	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
891974010870	ATP-grasp domain; Region: ATP-grasp_4; cl17255
891974010871	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
891974010872	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
891974010873	ATP-grasp domain; Region: ATP-grasp_4; cl17255
891974010874	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
891974010875	IMP binding site; other site
891974010876	dimer interface [polypeptide binding]; other site
891974010877	interdomain contacts; other site
891974010878	partial ornithine binding site; other site
891974010879	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
891974010880	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
891974010881	folate binding site [chemical binding]; other site
891974010882	NADP+ binding site [chemical binding]; other site
891974010883	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
891974010884	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
891974010885	active site
891974010886	metal binding site [ion binding]; metal-binding site
891974010887	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
891974010888	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
891974010889	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
891974010890	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
891974010891	SurA N-terminal domain; Region: SurA_N; pfam09312
891974010892	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
891974010893	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
891974010894	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
891974010895	OstA-like protein; Region: OstA; pfam03968
891974010896	Organic solvent tolerance protein; Region: OstA_C; pfam04453
891974010897	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
891974010898	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
891974010899	putative metal binding site [ion binding]; other site
891974010900	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
891974010901	HSP70 interaction site [polypeptide binding]; other site
891974010902	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
891974010903	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
891974010904	active site
891974010905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974010906	ATP-binding site [chemical binding]; other site
891974010907	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
891974010908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974010909	putative Mg++ binding site [ion binding]; other site
891974010910	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
891974010911	nucleotide binding region [chemical binding]; other site
891974010912	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
891974010913	ATP binding site [chemical binding]; other site
891974010914	DNA polymerase family B; Region: DNA_pol_B; pfam00136
891974010915	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
891974010916	active site
891974010917	metal-binding site
891974010918	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
891974010919	active site
891974010920	substrate binding site [chemical binding]; other site
891974010921	catalytic site [active]
891974010922	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
891974010923	catalytic site [active]
891974010924	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
891974010925	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
891974010926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974010927	Walker A/P-loop; other site
891974010928	ATP binding site [chemical binding]; other site
891974010929	Q-loop/lid; other site
891974010930	ABC transporter signature motif; other site
891974010931	Walker B; other site
891974010932	D-loop; other site
891974010933	H-loop/switch region; other site
891974010934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974010935	dimer interface [polypeptide binding]; other site
891974010936	conserved gate region; other site
891974010937	putative PBP binding loops; other site
891974010938	ABC-ATPase subunit interface; other site
891974010939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974010940	ABC-ATPase subunit interface; other site
891974010941	putative PBP binding loops; other site
891974010942	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974010943	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974010944	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974010945	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
891974010946	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974010947	Mor transcription activator family; Region: Mor; pfam08765
891974010948	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974010949	LysE type translocator; Region: LysE; cl00565
891974010950	LysE type translocator; Region: LysE; cl00565
891974010951	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974010952	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974010953	non-specific DNA binding site [nucleotide binding]; other site
891974010954	salt bridge; other site
891974010955	sequence-specific DNA binding site [nucleotide binding]; other site
891974010956	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974010957	AAA domain; Region: AAA_22; pfam13401
891974010958	Integrase core domain; Region: rve; pfam00665
891974010959	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974010960	Transcriptional regulator; Region: Rrf2; cl17282
891974010961	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974010962	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974010963	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974010964	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974010965	non-specific DNA binding site [nucleotide binding]; other site
891974010966	salt bridge; other site
891974010967	sequence-specific DNA binding site [nucleotide binding]; other site
891974010968	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
891974010969	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
891974010970	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974010971	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974010972	catalytic residue [active]
891974010973	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974010974	Phage Terminase; Region: Terminase_1; cl19862
891974010975	Terminase-like family; Region: Terminase_6; pfam03237
891974010976	Protein of unknown function (DUF935); Region: DUF935; pfam06074
891974010977	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974010978	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974010979	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974010980	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974010981	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974010982	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974010983	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974010984	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974010985	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974010986	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974010987	catalytic residues [active]
891974010988	catalytic nucleophile [active]
891974010989	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974010990	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974010991	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974010992	Synaptic Site I dimer interface [polypeptide binding]; other site
891974010993	DNA binding site [nucleotide binding]
891974010994	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974010995	DNA-binding interface [nucleotide binding]; DNA binding site
891974010996	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974010997	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974010998	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974010999	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
891974011000	active site
891974011001	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
891974011002	Flavodoxin; Region: Flavodoxin_1; pfam00258
891974011003	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
891974011004	FAD binding pocket [chemical binding]; other site
891974011005	FAD binding motif [chemical binding]; other site
891974011006	catalytic residues [active]
891974011007	NAD binding pocket [chemical binding]; other site
891974011008	phosphate binding motif [ion binding]; other site
891974011009	beta-alpha-beta structure motif; other site
891974011010	sulfite reductase subunit beta; Provisional; Region: PRK13504
891974011011	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
891974011012	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
891974011013	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
891974011014	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
891974011015	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
891974011016	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
891974011017	Active Sites [active]
891974011018	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974011019	metal binding site [ion binding]; metal-binding site
891974011020	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974011021	siroheme synthase; Provisional; Region: cysG; PRK10637
891974011022	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
891974011023	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
891974011024	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
891974011025	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
891974011026	active site
891974011027	SAM binding site [chemical binding]; other site
891974011028	homodimer interface [polypeptide binding]; other site
891974011029	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
891974011030	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
891974011031	Active Sites [active]
891974011032	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
891974011033	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
891974011034	CysD dimerization site [polypeptide binding]; other site
891974011035	G1 box; other site
891974011036	putative GEF interaction site [polypeptide binding]; other site
891974011037	GTP/Mg2+ binding site [chemical binding]; other site
891974011038	Switch I region; other site
891974011039	G2 box; other site
891974011040	G3 box; other site
891974011041	Switch II region; other site
891974011042	G4 box; other site
891974011043	G5 box; other site
891974011044	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
891974011045	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
891974011046	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
891974011047	ligand-binding site [chemical binding]; other site
891974011048	hypothetical protein; Provisional; Region: PRK10726
891974011049	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
891974011050	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
891974011051	substrate binding site; other site
891974011052	dimer interface; other site
891974011053	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
891974011054	homotrimer interaction site [polypeptide binding]; other site
891974011055	zinc binding site [ion binding]; other site
891974011056	CDP-binding sites; other site
891974011057	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
891974011058	Permutation of conserved domain; other site
891974011059	active site
891974011060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
891974011061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974011062	DNA binding site [nucleotide binding]
891974011063	domain linker motif; other site
891974011064	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
891974011065	dimerization interface [polypeptide binding]; other site
891974011066	ligand binding site [chemical binding]; other site
891974011067	Entomopoxvirus spheroidin protein; Region: Spheroidin; pfam05541
891974011068	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
891974011069	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
891974011070	active site
891974011071	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
891974011072	active site
891974011073	dimer interface [polypeptide binding]; other site
891974011074	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
891974011075	active site turn [active]
891974011076	phosphorylation site [posttranslational modification]
891974011077	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
891974011078	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974011079	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
891974011080	outer membrane porin, OprD family; Region: OprD; pfam03573
891974011081	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
891974011082	Survival protein SurE; Region: SurE; cl00448
891974011083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974011084	S-adenosylmethionine binding site [chemical binding]; other site
891974011085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
891974011086	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
891974011087	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
891974011088	Peptidase family M23; Region: Peptidase_M23; pfam01551
891974011089	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
891974011090	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
891974011091	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
891974011092	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
891974011093	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
891974011094	DNA binding residues [nucleotide binding]
891974011095	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
891974011096	MutS domain I; Region: MutS_I; pfam01624
891974011097	MutS domain II; Region: MutS_II; pfam05188
891974011098	MutS domain III; Region: MutS_III; pfam05192
891974011099	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
891974011100	Walker A/P-loop; other site
891974011101	ATP binding site [chemical binding]; other site
891974011102	Q-loop/lid; other site
891974011103	ABC transporter signature motif; other site
891974011104	Walker B; other site
891974011105	D-loop; other site
891974011106	H-loop/switch region; other site
891974011107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974011108	Transposase; Region: HTH_Tnp_1; cl17663
891974011109	Integrase core domain; Region: rve; pfam00665
891974011110	Integrase core domain; Region: rve_3; pfam13683
891974011111	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
891974011112	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
891974011113	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
891974011114	DinI-like family; Region: DinI; cl11630
891974011115	AAA domain; Region: AAA_23; pfam13476
891974011116	Walker A/P-loop; other site
891974011117	ATP binding site [chemical binding]; other site
891974011118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
891974011119	Walker B; other site
891974011120	D-loop; other site
891974011121	H-loop/switch region; other site
891974011122	Phage portal protein; Region: Phage_portal; cl19194
891974011123	Phage portal protein; Region: Phage_portal; cl19194
891974011124	terminase ATPase subunit; Provisional; Region: P; PHA02535
891974011125	terminase ATPase subunit; Provisional; Region: P; PHA02535
891974011126	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
891974011127	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
891974011128	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
891974011129	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
891974011130	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
891974011131	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
891974011132	AAA domain; Region: AAA_33; pfam13671
891974011133	ATP-binding site [chemical binding]; other site
891974011134	Gluconate-6-phosphate binding site [chemical binding]; other site
891974011135	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
891974011136	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974011137	DNA binding site [nucleotide binding]
891974011138	domain linker motif; other site
891974011139	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
891974011140	putative ligand binding site [chemical binding]; other site
891974011141	putative dimerization interface [polypeptide binding]; other site
891974011142	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
891974011143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974011144	Coenzyme A binding pocket [chemical binding]; other site
891974011145	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
891974011146	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
891974011147	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
891974011148	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
891974011149	Protein of unknown function (DUF2756); Region: DUF2756; cl08110
891974011150	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
891974011151	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
891974011152	putative active site [active]
891974011153	catalytic site [active]
891974011154	putative metal binding site [ion binding]; other site
891974011155	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
891974011156	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
891974011157	Walker A/P-loop; other site
891974011158	ATP binding site [chemical binding]; other site
891974011159	Q-loop/lid; other site
891974011160	ABC transporter signature motif; other site
891974011161	Walker B; other site
891974011162	D-loop; other site
891974011163	H-loop/switch region; other site
891974011164	TOBE domain; Region: TOBE_2; pfam08402
891974011165	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
891974011166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011167	ABC-ATPase subunit interface; other site
891974011168	putative PBP binding loops; other site
891974011169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974011170	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
891974011171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
891974011172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011173	dimer interface [polypeptide binding]; other site
891974011174	conserved gate region; other site
891974011175	ABC-ATPase subunit interface; other site
891974011176	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974011177	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974011178	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
891974011179	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
891974011180	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
891974011181	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
891974011182	Walker A/P-loop; other site
891974011183	ATP binding site [chemical binding]; other site
891974011184	Q-loop/lid; other site
891974011185	ABC transporter signature motif; other site
891974011186	Walker B; other site
891974011187	D-loop; other site
891974011188	H-loop/switch region; other site
891974011189	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
891974011190	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
891974011191	Walker A/P-loop; other site
891974011192	ATP binding site [chemical binding]; other site
891974011193	Q-loop/lid; other site
891974011194	ABC transporter signature motif; other site
891974011195	Walker B; other site
891974011196	D-loop; other site
891974011197	H-loop/switch region; other site
891974011198	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
891974011199	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
891974011200	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
891974011201	TM-ABC transporter signature motif; other site
891974011202	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
891974011203	TM-ABC transporter signature motif; other site
891974011204	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
891974011205	dimerization interface [polypeptide binding]; other site
891974011206	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
891974011207	ligand binding site [chemical binding]; other site
891974011208	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
891974011209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974011210	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974011211	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974011212	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974011213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011214	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
891974011215	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
891974011216	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
891974011217	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974011218	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974011219	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974011220	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
891974011221	NAD binding site [chemical binding]; other site
891974011222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011223	metabolite-proton symporter; Region: 2A0106; TIGR00883
891974011224	putative substrate translocation pore; other site
891974011225	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
891974011226	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
891974011227	dimer interface [polypeptide binding]; other site
891974011228	active site
891974011229	Schiff base residues; other site
891974011230	GAF domain; Region: GAF; pfam01590
891974011231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974011232	metal binding site [ion binding]; metal-binding site
891974011233	active site
891974011234	I-site; other site
891974011235	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974011236	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
891974011237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
891974011238	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
891974011239	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
891974011240	Autotransporter beta-domain; Region: Autotransporter; smart00869
891974011241	HI0933-like protein; Region: HI0933_like; pfam03486
891974011242	Predicted flavoproteins [General function prediction only]; Region: COG2081
891974011243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974011244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
891974011245	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
891974011246	universal stress protein UspB; Provisional; Region: PRK04960
891974011247	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974011248	Ligand Binding Site [chemical binding]; other site
891974011249	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974011250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
891974011251	Transposase; Region: DEDD_Tnp_IS110; pfam01548
891974011252	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
891974011253	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
891974011254	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
891974011255	enolase; Provisional; Region: eno; PRK00077
891974011256	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
891974011257	dimer interface [polypeptide binding]; other site
891974011258	metal binding site [ion binding]; metal-binding site
891974011259	substrate binding pocket [chemical binding]; other site
891974011260	CTP synthetase; Validated; Region: pyrG; PRK05380
891974011261	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
891974011262	Catalytic site [active]
891974011263	active site
891974011264	UTP binding site [chemical binding]; other site
891974011265	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
891974011266	active site
891974011267	putative oxyanion hole; other site
891974011268	catalytic triad [active]
891974011269	MazG family protein; Region: mazG; TIGR00444
891974011270	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
891974011271	homodimer interface [polypeptide binding]; other site
891974011272	metal binding site [ion binding]; metal-binding site
891974011273	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
891974011274	homodimer interface [polypeptide binding]; other site
891974011275	active site
891974011276	putative chemical substrate binding site [chemical binding]; other site
891974011277	metal binding site [ion binding]; metal-binding site
891974011278	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
891974011279	HD domain; Region: HD_4; pfam13328
891974011280	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
891974011281	synthetase active site [active]
891974011282	NTP binding site [chemical binding]; other site
891974011283	metal binding site [ion binding]; metal-binding site
891974011284	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
891974011285	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
891974011286	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
891974011287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
891974011288	S-adenosylmethionine binding site [chemical binding]; other site
891974011289	TRAM domain; Region: TRAM; pfam01938
891974011290	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
891974011291	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
891974011292	dimerization interface [polypeptide binding]; other site
891974011293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
891974011294	dimer interface [polypeptide binding]; other site
891974011295	phosphorylation site [posttranslational modification]
891974011296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974011297	ATP binding site [chemical binding]; other site
891974011298	Mg2+ binding site [ion binding]; other site
891974011299	G-X-G motif; other site
891974011300	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
891974011301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
891974011302	active site
891974011303	phosphorylation site [posttranslational modification]
891974011304	intermolecular recognition site; other site
891974011305	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
891974011306	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
891974011307	putative binding surface; other site
891974011308	active site
891974011309	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
891974011310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011312	putative substrate translocation pore; other site
891974011313	galactarate dehydratase; Region: galactar-dH20; TIGR03248
891974011314	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
891974011315	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
891974011316	flavodoxin; Provisional; Region: PRK08105
891974011317	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
891974011318	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
891974011319	probable active site [active]
891974011320	tRNA pseudouridine synthase C; Region: DUF446; cl01187
891974011321	SecY interacting protein Syd; Provisional; Region: PRK04968
891974011322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
891974011323	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
891974011324	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
891974011325	Domain of unknown function (DUF4478); Region: DUF4478; pfam14793
891974011326	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
891974011327	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
891974011328	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
891974011329	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
891974011330	flap endonuclease-like protein; Provisional; Region: PRK09482
891974011331	active site
891974011332	putative 5' ssDNA interaction site; other site
891974011333	metal binding site 3; metal-binding site
891974011334	metal binding site 1 [ion binding]; metal-binding site
891974011335	metal binding site 2 [ion binding]; metal-binding site
891974011336	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
891974011337	putative DNA binding site [nucleotide binding]; other site
891974011338	putative metal binding site [ion binding]; other site
891974011339	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
891974011340	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
891974011341	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
891974011342	Protein of unknown function (DUF423); Region: DUF423; cl01008
891974011343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974011344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974011345	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
891974011346	dimerization interface [polypeptide binding]; other site
891974011347	substrate binding pocket [chemical binding]; other site
891974011348	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
891974011349	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974011350	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
891974011351	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
891974011352	catalytic residue [active]
891974011353	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
891974011354	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
891974011355	putative ATP binding site [chemical binding]; other site
891974011356	putative substrate interface [chemical binding]; other site
891974011357	murein transglycosylase A; Provisional; Region: mltA; PRK11162
891974011358	MltA specific insert domain; Region: MltA; smart00925
891974011359	3D domain; Region: 3D; pfam06725
891974011360	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
891974011361	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
891974011362	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
891974011363	active site
891974011364	metal binding site [ion binding]; metal-binding site
891974011365	AMIN domain; Region: AMIN; pfam11741
891974011366	N-acetylglutamate synthase; Validated; Region: PRK05279
891974011367	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
891974011368	putative feedback inhibition sensing region; other site
891974011369	putative nucleotide binding site [chemical binding]; other site
891974011370	putative substrate binding site [chemical binding]; other site
891974011371	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
891974011372	Coenzyme A binding pocket [chemical binding]; other site
891974011373	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
891974011374	AAA domain; Region: AAA_30; pfam13604
891974011375	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
891974011376	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
891974011377	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
891974011378	protease3; Provisional; Region: PRK15101
891974011379	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
891974011380	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
891974011381	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
891974011382	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
891974011383	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
891974011384	Protein of unknown function (DUF2509); Region: DUF2509; cl11672
891974011385	hypothetical protein; Provisional; Region: PRK10557
891974011386	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
891974011387	hypothetical protein; Provisional; Region: PRK10506
891974011388	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
891974011389	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
891974011390	dimerization interface [polypeptide binding]; other site
891974011391	active site
891974011392	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
891974011393	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
891974011394	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
891974011395	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
891974011396	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
891974011397	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
891974011398	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
891974011399	putative active site [active]
891974011400	Ap4A binding site [chemical binding]; other site
891974011401	nudix motif; other site
891974011402	putative metal binding site [ion binding]; other site
891974011403	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
891974011404	putative DNA-binding cleft [nucleotide binding]; other site
891974011405	putative DNA clevage site; other site
891974011406	molecular lever; other site
891974011407	Integral membrane protein TerC family; Region: TerC; cl10468
891974011408	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
891974011409	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
891974011410	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974011411	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
891974011412	active site
891974011413	catalytic tetrad [active]
891974011414	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974011415	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
891974011416	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974011417	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
891974011418	acyl-activating enzyme (AAE) consensus motif; other site
891974011419	active site
891974011420	AMP binding site [chemical binding]; other site
891974011421	CoA binding site [chemical binding]; other site
891974011422	Outer membrane efflux protein; Region: OEP; pfam02321
891974011423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
891974011424	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
891974011425	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
891974011426	MMPL family; Region: MMPL; cl14618
891974011427	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
891974011428	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
891974011429	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
891974011430	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
891974011431	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974011432	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974011433	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
891974011434	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
891974011435	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
891974011436	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
891974011437	molybdopterin cofactor binding site; other site
891974011438	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
891974011439	molybdopterin cofactor binding site; other site
891974011440	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
891974011441	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974011442	DNA binding site [nucleotide binding]
891974011443	domain linker motif; other site
891974011444	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
891974011445	dimerization interface (closed form) [polypeptide binding]; other site
891974011446	ligand binding site [chemical binding]; other site
891974011447	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
891974011448	diaminopimelate decarboxylase; Provisional; Region: PRK11165
891974011449	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
891974011450	active site
891974011451	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
891974011452	substrate binding site [chemical binding]; other site
891974011453	catalytic residues [active]
891974011454	dimer interface [polypeptide binding]; other site
891974011455	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
891974011456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974011457	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
891974011458	dimerization interface [polypeptide binding]; other site
891974011459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011460	putative substrate translocation pore; other site
891974011461	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974011462	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
891974011463	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
891974011464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011465	dimer interface [polypeptide binding]; other site
891974011466	conserved gate region; other site
891974011467	putative PBP binding loops; other site
891974011468	ABC-ATPase subunit interface; other site
891974011469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011470	ABC-ATPase subunit interface; other site
891974011471	putative PBP binding loops; other site
891974011472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011473	dimer interface [polypeptide binding]; other site
891974011474	conserved gate region; other site
891974011475	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
891974011476	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
891974011477	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
891974011478	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974011479	membrane-bound complex binding site; other site
891974011480	hinge residues; other site
891974011481	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
891974011482	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974011483	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974011484	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974011485	putative active site [active]
891974011486	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974011487	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974011488	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
891974011489	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
891974011490	dimer interface [polypeptide binding]; other site
891974011491	putative anticodon binding site; other site
891974011492	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
891974011493	motif 1; other site
891974011494	active site
891974011495	motif 2; other site
891974011496	motif 3; other site
891974011497	peptide chain release factor 2; Validated; Region: prfB; PRK00578
891974011498	This domain is found in peptide chain release factors; Region: PCRF; smart00937
891974011499	RF-1 domain; Region: RF-1; pfam00472
891974011500	Subtilase family; Region: Peptidase_S8; pfam00082
891974011501	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
891974011502	catalytic triad [active]
891974011503	putative active site [active]
891974011504	Protein of unknown function (DUF342); Region: DUF342; cl19219
891974011505	Autotransporter beta-domain; Region: Autotransporter; pfam03797
891974011506	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
891974011507	DHH family; Region: DHH; pfam01368
891974011508	DHHA1 domain; Region: DHHA1; pfam02272
891974011509	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
891974011510	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
891974011511	dimerization domain [polypeptide binding]; other site
891974011512	dimer interface [polypeptide binding]; other site
891974011513	catalytic residues [active]
891974011514	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
891974011515	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
891974011516	active site
891974011517	Int/Topo IB signature motif; other site
891974011518	flavodoxin FldB; Provisional; Region: PRK12359
891974011519	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
891974011520	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
891974011521	putative global regulator; Reviewed; Region: PRK09559
891974011522	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
891974011523	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
891974011524	hemolysin; Provisional; Region: PRK15087
891974011525	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
891974011526	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
891974011527	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
891974011528	putative active site [active]
891974011529	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
891974011530	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
891974011531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
891974011532	classical (c) SDRs; Region: SDR_c; cd05233
891974011533	active site
891974011534	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
891974011535	active site
891974011536	homotetramer interface [polypeptide binding]; other site
891974011537	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
891974011538	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
891974011539	heme binding site [chemical binding]; other site
891974011540	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
891974011541	heme binding site [chemical binding]; other site
891974011542	C-N hydrolase family amidase; Provisional; Region: PRK10438
891974011543	active site
891974011544	catalytic triad [active]
891974011545	dimer interface [polypeptide binding]; other site
891974011546	methionine aminotransferase; Validated; Region: PRK09082
891974011547	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974011548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974011549	homodimer interface [polypeptide binding]; other site
891974011550	catalytic residue [active]
891974011551	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
891974011552	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
891974011553	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
891974011554	active site
891974011555	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
891974011556	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
891974011557	dimer interface [polypeptide binding]; other site
891974011558	active site
891974011559	Glutamine amidotransferases class-II; Region: GATase_4; pfam13230
891974011560	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
891974011561	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
891974011562	putative active site [active]
891974011563	putative dimer interface [polypeptide binding]; other site
891974011564	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
891974011565	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
891974011566	Y-family of DNA polymerases; Region: PolY; cl12025
891974011567	DNA polymerase IV; Validated; Region: PRK02406
891974011568	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
891974011569	DNA binding site [nucleotide binding]
891974011570	DNA polymerase IV; Validated; Region: PRK02406
891974011571	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
891974011572	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
891974011573	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
891974011574	metal binding site [ion binding]; metal-binding site
891974011575	dimer interface [polypeptide binding]; other site
891974011576	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974011577	active site
891974011578	Putative lysophospholipase; Region: Hydrolase_4; cl19140
891974011579	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
891974011580	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
891974011581	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
891974011582	trimer interface [polypeptide binding]; other site
891974011583	eyelet of channel; other site
891974011584	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
891974011585	gamma-glutamyl kinase; Provisional; Region: PRK05429
891974011586	nucleotide binding site [chemical binding]; other site
891974011587	PUA domain; Region: PUA; pfam01472
891974011588	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974011589	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974011590	catalytic residues [active]
891974011591	catalytic nucleophile [active]
891974011592	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974011593	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974011594	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974011595	Synaptic Site I dimer interface [polypeptide binding]; other site
891974011596	DNA binding site [nucleotide binding]
891974011597	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974011598	DNA-binding interface [nucleotide binding]; DNA binding site
891974011599	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974011600	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974011601	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974011602	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974011603	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974011604	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974011605	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974011606	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974011607	Protein of unknown function (DUF935); Region: DUF935; pfam06074
891974011608	Phage Terminase; Region: Terminase_1; cl19862
891974011609	Terminase-like family; Region: Terminase_6; pfam03237
891974011610	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974011611	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974011612	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974011613	catalytic residue [active]
891974011614	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
891974011615	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
891974011616	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974011617	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974011618	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974011619	non-specific DNA binding site [nucleotide binding]; other site
891974011620	salt bridge; other site
891974011621	sequence-specific DNA binding site [nucleotide binding]; other site
891974011622	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974011623	Transcriptional regulator; Region: Rrf2; cl17282
891974011624	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974011625	Integrase core domain; Region: rve; pfam00665
891974011626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974011627	non-specific DNA binding site [nucleotide binding]; other site
891974011628	salt bridge; other site
891974011629	sequence-specific DNA binding site [nucleotide binding]; other site
891974011630	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974011631	AAA domain; Region: AAA_22; pfam13401
891974011632	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974011633	LysE type translocator; Region: LysE; cl00565
891974011634	LysE type translocator; Region: LysE; cl00565
891974011635	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974011636	Mor transcription activator family; Region: Mor; pfam08765
891974011637	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974011638	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011639	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011640	NAD(P) binding site [chemical binding]; other site
891974011641	catalytic residues [active]
891974011642	Predicted transcriptional regulator [Transcription]; Region: COG2932
891974011643	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
891974011644	Catalytic site [active]
891974011645	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
891974011646	catalytic residue [active]
891974011647	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
891974011648	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011649	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
891974011650	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
891974011651	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
891974011652	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
891974011653	homodimer interface [polypeptide binding]; other site
891974011654	NADP binding site [chemical binding]; other site
891974011655	substrate binding site [chemical binding]; other site
891974011656	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
891974011657	RNA binding surface [nucleotide binding]; other site
891974011658	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
891974011659	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
891974011660	active site
891974011661	HIGH motif; other site
891974011662	KMSKS motif; other site
891974011663	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
891974011664	tRNA binding surface [nucleotide binding]; other site
891974011665	anticodon binding site; other site
891974011666	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
891974011667	substrate binding site [chemical binding]; other site
891974011668	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
891974011669	putative active site [active]
891974011670	putative metal binding site [ion binding]; other site
891974011671	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
891974011672	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
891974011673	ATP-grasp domain; Region: ATP-grasp_4; cl17255
891974011674	Methyltransferase domain; Region: Methyltransf_23; pfam13489
891974011675	FtsX-like permease family; Region: FtsX; pfam02687
891974011676	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
891974011677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011678	Walker A/P-loop; other site
891974011679	ATP binding site [chemical binding]; other site
891974011680	Q-loop/lid; other site
891974011681	ABC transporter signature motif; other site
891974011682	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
891974011683	active site
891974011684	catalytic triad [active]
891974011685	oxyanion hole [active]
891974011686	switch loop; other site
891974011687	short chain dehydrogenase; Validated; Region: PRK06182
891974011688	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
891974011689	NADP binding site [chemical binding]; other site
891974011690	active site
891974011691	steroid binding site; other site
891974011692	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
891974011693	Tetratricopeptide repeat; Region: TPR_19; pfam14559
891974011694	Tetratricopeptide repeat; Region: TPR_20; pfam14561
891974011695	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
891974011696	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
891974011697	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
891974011698	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
891974011699	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
891974011700	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
891974011701	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
891974011702	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
891974011703	DNA binding residues [nucleotide binding]
891974011704	dimer interface [polypeptide binding]; other site
891974011705	copper binding site [ion binding]; other site
891974011706	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
891974011707	metal-binding site [ion binding]
891974011708	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
891974011709	metal-binding site [ion binding]
891974011710	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
891974011711	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
891974011712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974011713	motif II; other site
891974011714	TraB family; Region: TraB; cl12050
891974011715	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
891974011716	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
891974011717	putative deacylase active site [active]
891974011718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
891974011719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974011720	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
891974011721	dimerization interface [polypeptide binding]; other site
891974011722	Predicted membrane protein [Function unknown]; Region: COG4125
891974011723	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
891974011724	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
891974011725	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
891974011726	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
891974011727	active site
891974011728	metal binding site [ion binding]; metal-binding site
891974011729	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
891974011730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011731	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974011732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011733	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
891974011734	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
891974011735	TrkA-N domain; Region: TrkA_N; pfam02254
891974011736	putative cation:proton antiport protein; Provisional; Region: PRK10669
891974011737	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974011738	ATP binding site [chemical binding]; other site
891974011739	substrate binding site [chemical binding]; other site
891974011740	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974011741	ferrochelatase; Reviewed; Region: hemH; PRK00035
891974011742	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
891974011743	C-terminal domain interface [polypeptide binding]; other site
891974011744	active site
891974011745	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
891974011746	active site
891974011747	N-terminal domain interface [polypeptide binding]; other site
891974011748	adenylate kinase; Reviewed; Region: adk; PRK00279
891974011749	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
891974011750	AMP-binding site [chemical binding]; other site
891974011751	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
891974011752	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
891974011753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
891974011754	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
891974011755	dimerization interface [polypeptide binding]; other site
891974011756	substrate binding pocket [chemical binding]; other site
891974011757	heat shock protein 90; Provisional; Region: PRK05218
891974011758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
891974011759	ATP binding site [chemical binding]; other site
891974011760	Mg2+ binding site [ion binding]; other site
891974011761	G-X-G motif; other site
891974011762	Hsp90 protein; Region: HSP90; pfam00183
891974011763	recombination protein RecR; Reviewed; Region: recR; PRK00076
891974011764	RecR protein; Region: RecR; pfam02132
891974011765	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
891974011766	putative active site [active]
891974011767	putative metal-binding site [ion binding]; other site
891974011768	tetramer interface [polypeptide binding]; other site
891974011769	hypothetical protein; Validated; Region: PRK00153
891974011770	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
891974011771	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
891974011772	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
891974011773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974011774	Walker A motif; other site
891974011775	ATP binding site [chemical binding]; other site
891974011776	Walker B motif; other site
891974011777	DNA polymerase III subunit delta'; Validated; Region: PRK08485
891974011778	arginine finger; other site
891974011779	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
891974011780	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
891974011781	active site
891974011782	hypothetical protein; Provisional; Region: PRK10527
891974011783	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
891974011784	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
891974011785	hypothetical protein; Provisional; Region: PRK11038
891974011786	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
891974011787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974011788	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
891974011789	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
891974011790	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974011791	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974011792	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
891974011793	MMPL family; Region: MMPL; cl14618
891974011794	MMPL family; Region: MMPL; cl14618
891974011795	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
891974011796	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
891974011797	metal binding site [ion binding]; metal-binding site
891974011798	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
891974011799	ABC-ATPase subunit  interface; other site
891974011800	dimer interface [polypeptide binding]; other site
891974011801	putative PBP binding regions; other site
891974011802	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011803	H-loop/switch region; other site
891974011804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011805	Walker A/P-loop; other site
891974011806	ATP binding site [chemical binding]; other site
891974011807	Biofilm formation regulator YbaJ; Region: YbaJ; cl11675
891974011808	Haemolysin expression modulating protein; Region: HHA; cl11501
891974011809	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
891974011810	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
891974011811	DNA binding site [nucleotide binding]
891974011812	active site
891974011813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
891974011814	acyl-CoA thioesterase II; Provisional; Region: PRK10526
891974011815	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
891974011816	active site
891974011817	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
891974011818	catalytic triad [active]
891974011819	dimer interface [polypeptide binding]; other site
891974011820	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
891974011821	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
891974011822	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
891974011823	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
891974011824	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974011825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011826	Walker A/P-loop; other site
891974011827	ATP binding site [chemical binding]; other site
891974011828	Q-loop/lid; other site
891974011829	ABC transporter signature motif; other site
891974011830	Walker B; other site
891974011831	D-loop; other site
891974011832	H-loop/switch region; other site
891974011833	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
891974011834	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
891974011835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011836	Walker A/P-loop; other site
891974011837	ATP binding site [chemical binding]; other site
891974011838	Q-loop/lid; other site
891974011839	ABC transporter signature motif; other site
891974011840	Walker B; other site
891974011841	D-loop; other site
891974011842	H-loop/switch region; other site
891974011843	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
891974011844	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
891974011845	dimerization interface [polypeptide binding]; other site
891974011846	putative DNA binding site [nucleotide binding]; other site
891974011847	putative Zn2+ binding site [ion binding]; other site
891974011848	AsnC family; Region: AsnC_trans_reg; pfam01037
891974011849	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974011850	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
891974011851	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
891974011852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974011853	active site
891974011854	motif I; other site
891974011855	motif II; other site
891974011856	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
891974011857	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
891974011858	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974011859	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
891974011860	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
891974011861	Ligand Binding Site [chemical binding]; other site
891974011862	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
891974011863	active site
891974011864	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
891974011865	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
891974011866	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
891974011867	periplasmic folding chaperone; Provisional; Region: PRK10788
891974011868	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
891974011869	SurA N-terminal domain; Region: SurA_N_3; cl07813
891974011870	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
891974011871	histone-like DNA-binding protein HU; Region: HU; cd13831
891974011872	dimer interface [polypeptide binding]; other site
891974011873	DNA binding site [nucleotide binding]
891974011874	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
891974011875	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
891974011876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974011877	Walker A motif; other site
891974011878	ATP binding site [chemical binding]; other site
891974011879	Walker B motif; other site
891974011880	arginine finger; other site
891974011881	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
891974011882	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
891974011883	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
891974011884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974011885	Walker A motif; other site
891974011886	ATP binding site [chemical binding]; other site
891974011887	Walker B motif; other site
891974011888	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
891974011889	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
891974011890	oligomer interface [polypeptide binding]; other site
891974011891	active site residues [active]
891974011892	trigger factor; Provisional; Region: tig; PRK01490
891974011893	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
891974011894	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
891974011895	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
891974011896	transcriptional regulator BolA; Provisional; Region: PRK11628
891974011897	hypothetical protein; Provisional; Region: PRK11627
891974011898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011899	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974011900	putative substrate translocation pore; other site
891974011901	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
891974011902	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
891974011903	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
891974011904	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
891974011905	D-pathway; other site
891974011906	Putative ubiquinol binding site [chemical binding]; other site
891974011907	Low-spin heme (heme b) binding site [chemical binding]; other site
891974011908	Putative water exit pathway; other site
891974011909	Binuclear center (heme o3/CuB) [ion binding]; other site
891974011910	K-pathway; other site
891974011911	Putative proton exit pathway; other site
891974011912	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
891974011913	Subunit I/III interface [polypeptide binding]; other site
891974011914	Subunit III/IV interface [polypeptide binding]; other site
891974011915	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
891974011916	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
891974011917	putative active site [active]
891974011918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974011919	Major Facilitator Superfamily; Region: MFS_1; pfam07690
891974011920	putative substrate translocation pore; other site
891974011921	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974011922	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
891974011923	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974011924	NAD(P) binding site [chemical binding]; other site
891974011925	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011926	NAD(P) binding site [chemical binding]; other site
891974011927	catalytic residues [active]
891974011928	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011929	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
891974011930	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
891974011931	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
891974011932	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
891974011933	Walker A motif; other site
891974011934	ATP binding site [chemical binding]; other site
891974011935	Walker B motif; other site
891974011936	arginine finger; other site
891974011937	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
891974011938	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
891974011939	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
891974011940	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
891974011941	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
891974011942	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
891974011943	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
891974011944	conserved cys residue [active]
891974011945	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
891974011946	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
891974011947	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
891974011948	Ligand Binding Site [chemical binding]; other site
891974011949	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
891974011950	active site residue [active]
891974011951	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
891974011952	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
891974011953	substrate binding pocket [chemical binding]; other site
891974011954	chain length determination region; other site
891974011955	substrate-Mg2+ binding site; other site
891974011956	catalytic residues [active]
891974011957	aspartate-rich region 1; other site
891974011958	active site lid residues [active]
891974011959	aspartate-rich region 2; other site
891974011960	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
891974011961	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
891974011962	TPP-binding site; other site
891974011963	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
891974011964	PYR/PP interface [polypeptide binding]; other site
891974011965	dimer interface [polypeptide binding]; other site
891974011966	TPP binding site [chemical binding]; other site
891974011967	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
891974011968	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
891974011969	catalytic tetrad [active]
891974011970	Immunoglobulin domain; Region: Ig; cl11960
891974011971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
891974011972	dimer interface [polypeptide binding]; other site
891974011973	conserved gate region; other site
891974011974	putative PBP binding loops; other site
891974011975	ABC-ATPase subunit interface; other site
891974011976	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
891974011977	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011978	Q-loop/lid; other site
891974011979	ABC transporter signature motif; other site
891974011980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
891974011981	Walker A/P-loop; other site
891974011982	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
891974011983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
891974011984	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
891974011985	FAD binding domain; Region: FAD_binding_4; pfam01565
891974011986	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
891974011987	Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537
891974011988	substrate binding site; other site
891974011989	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
891974011990	Manganese binding site; other site
891974011991	dimer interface; other site
891974011992	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
891974011993	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
891974011994	putative di-iron ligands [ion binding]; other site
891974011995	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
891974011996	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
891974011997	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
891974011998	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
891974011999	Elongation Factor G, domain II; Region: EFG_II; pfam14492
891974012000	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
891974012001	G5 box; other site
891974012002	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
891974012003	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
891974012004	Switch II region; other site
891974012005	G4 box; other site
891974012006	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
891974012007	G1 box; other site
891974012008	GTP/Mg2+ binding site [chemical binding]; other site
891974012009	G2 box; other site
891974012010	Switch I region; other site
891974012011	G3 box; other site
891974012012	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
891974012013	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
891974012014	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
891974012015	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
891974012016	putative active site [active]
891974012017	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
891974012018	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
891974012019	DNA binding site [nucleotide binding]
891974012020	domain linker motif; other site
891974012021	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974012022	hypothetical protein; Provisional; Region: PRK05423
891974012023	Predicted membrane protein [Function unknown]; Region: COG1289
891974012024	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
891974012025	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974012026	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
891974012027	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
891974012028	exonuclease I; Provisional; Region: sbcB; PRK11779
891974012029	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
891974012030	active site
891974012031	catalytic site [active]
891974012032	substrate binding site [chemical binding]; other site
891974012033	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
891974012034	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
891974012035	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
891974012036	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
891974012037	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
891974012038	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
891974012039	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
891974012040	catalytic triad [active]
891974012041	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
891974012042	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974012043	non-specific DNA binding site [nucleotide binding]; other site
891974012044	salt bridge; other site
891974012045	sequence-specific DNA binding site [nucleotide binding]; other site
891974012046	Cupin domain; Region: Cupin_2; pfam07883
891974012047	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
891974012048	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
891974012049	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
891974012050	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
891974012051	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
891974012052	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
891974012053	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
891974012054	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
891974012055	putative NAD(P) binding site [chemical binding]; other site
891974012056	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
891974012057	ATP phosphoribosyltransferase; Region: HisG; pfam01634
891974012058	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
891974012059	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
891974012060	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
891974012061	NAD binding site [chemical binding]; other site
891974012062	dimerization interface [polypeptide binding]; other site
891974012063	product binding site; other site
891974012064	substrate binding site [chemical binding]; other site
891974012065	zinc binding site [ion binding]; other site
891974012066	catalytic residues [active]
891974012067	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
891974012068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
891974012069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
891974012070	homodimer interface [polypeptide binding]; other site
891974012071	catalytic residue [active]
891974012072	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
891974012073	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
891974012074	active site
891974012075	motif I; other site
891974012076	motif II; other site
891974012077	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
891974012078	putative active site pocket [active]
891974012079	4-fold oligomerization interface [polypeptide binding]; other site
891974012080	metal binding residues [ion binding]; metal-binding site
891974012081	3-fold/trimer interface [polypeptide binding]; other site
891974012082	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
891974012083	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
891974012084	putative active site [active]
891974012085	oxyanion strand; other site
891974012086	catalytic triad [active]
891974012087	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
891974012088	catalytic residues [active]
891974012089	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
891974012090	substrate binding site [chemical binding]; other site
891974012091	glutamase interaction surface [polypeptide binding]; other site
891974012092	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
891974012093	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
891974012094	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
891974012095	metal binding site [ion binding]; metal-binding site
891974012096	HipA-like C-terminal domain; Region: HipA_C; pfam07804
891974012097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974012098	non-specific DNA binding site [nucleotide binding]; other site
891974012099	salt bridge; other site
891974012100	sequence-specific DNA binding site [nucleotide binding]; other site
891974012101	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
891974012102	putative deacylase active site [active]
891974012103	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
891974012104	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
891974012105	substrate binding pocket [chemical binding]; other site
891974012106	membrane-bound complex binding site; other site
891974012107	hinge residues; other site
891974012108	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
891974012109	active site
891974012110	Zn binding site [ion binding]; other site
891974012111	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
891974012112	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
891974012113	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
891974012114	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
891974012115	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
891974012116	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974012117	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
891974012118	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
891974012119	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
891974012120	Cupin domain; Region: Cupin_2; cl17218
891974012121	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
891974012122	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
891974012123	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
891974012124	NAD binding site [chemical binding]; other site
891974012125	homodimer interface [polypeptide binding]; other site
891974012126	active site
891974012127	substrate binding site [chemical binding]; other site
891974012128	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
891974012129	active site
891974012130	tetramer interface; other site
891974012131	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
891974012132	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
891974012133	putative ADP-binding pocket [chemical binding]; other site
891974012134	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
891974012135	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
891974012136	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
891974012137	Head binding; Region: Head_binding; pfam09008
891974012138	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
891974012139	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
891974012140	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
891974012141	putative ADP-binding pocket [chemical binding]; other site
891974012142	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
891974012143	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974012144	active site
891974012145	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
891974012146	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
891974012147	active site
891974012148	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974012149	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
891974012150	Chain length determinant protein; Region: Wzz; pfam02706
891974012151	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
891974012152	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
891974012153	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
891974012154	Low molecular weight phosphatase family; Region: LMWPc; cl00105
891974012155	Low molecular weight phosphatase family; Region: LMWPc; cl00105
891974012156	active site
891974012157	polysaccharide export protein Wza; Provisional; Region: PRK15078
891974012158	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
891974012159	SLBB domain; Region: SLBB; pfam10531
891974012160	Bacterial sugar transferase; Region: Bac_transf; pfam02397
891974012161	CoA binding domain; Region: CoA_binding; cl17356
891974012162	Bacterial sugar transferase; Region: Bac_transf; cl00939
891974012163	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
891974012164	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
891974012165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
891974012166	Transporter associated domain; Region: CorC_HlyC; smart01091
891974012167	putative assembly protein; Provisional; Region: PRK10833
891974012168	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
891974012169	putative assembly protein; Provisional; Region: PRK10833
891974012170	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
891974012171	trimer interface [polypeptide binding]; other site
891974012172	active site
891974012173	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
891974012174	ATP-binding site [chemical binding]; other site
891974012175	Sugar specificity; other site
891974012176	Pyrimidine base specificity; other site
891974012177	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
891974012178	active site
891974012179	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
891974012180	MASE1; Region: MASE1; cl17823
891974012181	putative diguanylate cyclase; Provisional; Region: PRK09776
891974012182	PAS domain S-box; Region: sensory_box; TIGR00229
891974012183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974012184	putative active site [active]
891974012185	heme pocket [chemical binding]; other site
891974012186	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
891974012187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974012188	putative active site [active]
891974012189	heme pocket [chemical binding]; other site
891974012190	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974012191	metal binding site [ion binding]; metal-binding site
891974012192	active site
891974012193	I-site; other site
891974012194	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974012195	nucleotide binding site [chemical binding]; other site
891974012196	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974012197	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974012198	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
891974012199	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
891974012200	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
891974012201	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
891974012202	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
891974012203	catalytic tetrad [active]
891974012204	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
891974012205	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
891974012206	HlyD family secretion protein; Region: HlyD_3; pfam13437
891974012207	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
891974012208	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
891974012209	Integrase core domain; Region: rve; pfam00665
891974012210	Integrase core domain; Region: rve_3; pfam13683
891974012211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
891974012212	hypothetical protein; Provisional; Region: PRK10519
891974012213	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
891974012214	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974012215	metal binding site [ion binding]; metal-binding site
891974012216	Protein of unknown function (DUF551); Region: DUF551; pfam04448
891974012217	Mor transcription activator family; Region: Mor; cl02360
891974012218	Mor transcription activator family; Region: Mor; cl02360
891974012219	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
891974012220	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
891974012221	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974012222	non-specific DNA binding site [nucleotide binding]; other site
891974012223	salt bridge; other site
891974012224	sequence-specific DNA binding site [nucleotide binding]; other site
891974012225	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
891974012226	AAA domain; Region: AAA_22; pfam13401
891974012227	Integrase core domain; Region: rve; pfam00665
891974012228	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974012229	Transcriptional regulator; Region: Rrf2; cl17282
891974012230	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
891974012231	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
891974012232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
891974012233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
891974012234	non-specific DNA binding site [nucleotide binding]; other site
891974012235	salt bridge; other site
891974012236	sequence-specific DNA binding site [nucleotide binding]; other site
891974012237	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
891974012238	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
891974012239	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
891974012240	N-acetyl-D-glucosamine binding site [chemical binding]; other site
891974012241	catalytic residue [active]
891974012242	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
891974012243	Phage Terminase; Region: Terminase_1; cl19862
891974012244	Terminase-like family; Region: Terminase_6; pfam03237
891974012245	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974012246	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974012247	Protein of unknown function (DUF935); Region: DUF935; cl19863
891974012248	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
891974012249	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
891974012250	Mu-like prophage I protein; Region: Mu-like_Pro; cl19864
891974012251	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
891974012252	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
891974012253	Gp37 protein; Region: Gp37; pfam09646
891974012254	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
891974012255	Phage tail tube protein FII; Region: Phage_tube; pfam04985
891974012256	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
891974012257	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
891974012258	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
891974012259	Phage Tail Protein X; Region: Phage_tail_X; cl02088
891974012260	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
891974012261	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
891974012262	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
891974012263	Baseplate J-like protein; Region: Baseplate_J; cl01294
891974012264	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
891974012265	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
891974012266	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974012267	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974012268	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974012269	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974012270	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974012271	catalytic residues [active]
891974012272	catalytic nucleophile [active]
891974012273	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974012274	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974012275	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974012276	Synaptic Site I dimer interface [polypeptide binding]; other site
891974012277	DNA binding site [nucleotide binding]
891974012278	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974012279	DNA-binding interface [nucleotide binding]; DNA binding site
891974012280	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
891974012281	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
891974012282	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
891974012283	G1 box; other site
891974012284	putative GEF interaction site [polypeptide binding]; other site
891974012285	GTP/Mg2+ binding site [chemical binding]; other site
891974012286	Switch I region; other site
891974012287	G2 box; other site
891974012288	G3 box; other site
891974012289	Switch II region; other site
891974012290	G4 box; other site
891974012291	G5 box; other site
891974012292	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
891974012293	Elongation Factor G, domain II; Region: EFG_II; pfam14492
891974012294	periplasmic protein; Provisional; Region: PRK10568
891974012295	BON domain; Region: BON; pfam04972
891974012296	BON domain; Region: BON; pfam04972
891974012297	Small integral membrane protein [Function unknown]; Region: COG5487
891974012298	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
891974012299	active site
891974012300	nucleophile elbow; other site
891974012301	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
891974012302	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
891974012303	active site
891974012304	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
891974012305	intersubunit interface [polypeptide binding]; other site
891974012306	active site
891974012307	catalytic residue [active]
891974012308	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
891974012309	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
891974012310	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
891974012311	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
891974012312	phosphopentomutase; Provisional; Region: PRK05362
891974012313	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
891974012314	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
891974012315	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974012316	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974012317	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
891974012318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
891974012319	metal binding site [ion binding]; metal-binding site
891974012320	active site
891974012321	I-site; other site
891974012322	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
891974012323	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
891974012324	putative CheW interface [polypeptide binding]; other site
891974012325	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
891974012326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974012327	putative active site [active]
891974012328	heme pocket [chemical binding]; other site
891974012329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
891974012330	putative active site [active]
891974012331	heme pocket [chemical binding]; other site
891974012332	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
891974012333	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
891974012334	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
891974012335	active site
891974012336	catalytic residues [active]
891974012337	DNA binding site [nucleotide binding]
891974012338	Int/Topo IB signature motif; other site
891974012339	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
891974012340	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
891974012341	nucleotide binding site [chemical binding]; other site
891974012342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
891974012343	polyol permease family; Region: 2A0118; TIGR00897
891974012344	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
891974012345	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974012346	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974012347	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
891974012348	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
891974012349	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
891974012350	active site
891974012351	phosphorylation site [posttranslational modification]
891974012352	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
891974012353	active site
891974012354	P-loop; other site
891974012355	phosphorylation site [posttranslational modification]
891974012356	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
891974012357	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
891974012358	NAD(P) binding site [chemical binding]; other site
891974012359	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
891974012360	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
891974012361	putative ATP binding site [chemical binding]; other site
891974012362	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
891974012363	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
891974012364	dimerization domain swap beta strand [polypeptide binding]; other site
891974012365	regulatory protein interface [polypeptide binding]; other site
891974012366	active site
891974012367	regulatory phosphorylation site [posttranslational modification]; other site
891974012368	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
891974012369	Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism]; Region: MtlA; COG4668
891974012370	active site
891974012371	phosphorylation site [posttranslational modification]
891974012372	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
891974012373	active site
891974012374	P-loop; other site
891974012375	phosphorylation site [posttranslational modification]
891974012376	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
891974012377	putative ATP binding site [chemical binding]; other site
891974012378	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
891974012379	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
891974012380	substrate binding site [chemical binding]; other site
891974012381	ATP binding site [chemical binding]; other site
891974012382	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
891974012383	TM-ABC transporter signature motif; other site
891974012384	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
891974012385	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
891974012386	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
891974012387	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
891974012388	Walker A/P-loop; other site
891974012389	ATP binding site [chemical binding]; other site
891974012390	Q-loop/lid; other site
891974012391	ABC transporter signature motif; other site
891974012392	Walker B; other site
891974012393	D-loop; other site
891974012394	H-loop/switch region; other site
891974012395	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974012396	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974012397	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
891974012398	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
891974012399	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
891974012400	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
891974012401	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
891974012402	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
891974012403	substrate binding site [chemical binding]; other site
891974012404	ATP binding site [chemical binding]; other site
891974012405	Uncharacterized conserved protein [Function unknown]; Region: COG4095
891974012406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
891974012407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974012408	Ligand Binding Site [chemical binding]; other site
891974012409	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
891974012410	Ligand Binding Site [chemical binding]; other site
891974012411	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
891974012412	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
891974012413	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974012414	catalytic residues [active]
891974012415	catalytic nucleophile [active]
891974012416	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974012417	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974012418	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974012419	Synaptic Site I dimer interface [polypeptide binding]; other site
891974012420	DNA binding site [nucleotide binding]
891974012421	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974012422	DNA-binding interface [nucleotide binding]; DNA binding site
891974012423	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974012424	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
891974012425	Tail fiber protein gp37 C terminal; Region: gp37_C; pfam12604
891974012426	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
891974012427	multiple promoter invertase; Provisional; Region: mpi; PRK13413
891974012428	catalytic residues [active]
891974012429	catalytic nucleophile [active]
891974012430	Presynaptic Site I dimer interface [polypeptide binding]; other site
891974012431	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
891974012432	Synaptic Flat tetramer interface [polypeptide binding]; other site
891974012433	Synaptic Site I dimer interface [polypeptide binding]; other site
891974012434	DNA binding site [nucleotide binding]
891974012435	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
891974012436	DNA-binding interface [nucleotide binding]; DNA binding site