-- dump date 20140619_234554 -- class Genbank::misc_feature -- table misc_feature_note -- id note 118163000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 118163000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 118163000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163000004 Walker A motif; other site 118163000005 ATP binding site [chemical binding]; other site 118163000006 Walker B motif; other site 118163000007 arginine finger; other site 118163000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 118163000009 DnaA box-binding interface [nucleotide binding]; other site 118163000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 118163000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 118163000012 putative DNA binding surface [nucleotide binding]; other site 118163000013 dimer interface [polypeptide binding]; other site 118163000014 beta-clamp/clamp loader binding surface; other site 118163000015 beta-clamp/translesion DNA polymerase binding surface; other site 118163000016 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 118163000017 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 118163000018 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 118163000019 Protein of unknown function, DUF608; Region: DUF608; pfam04685 118163000020 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 118163000021 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 118163000022 Integral membrane protein DUF92; Region: DUF92; pfam01940 118163000023 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 118163000024 AAA domain; Region: AAA_18; pfam13238 118163000025 ligand-binding site [chemical binding]; other site 118163000026 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 118163000027 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 118163000028 active site residue [active] 118163000029 Iron permease FTR1 family; Region: FTR1; cl00475 118163000030 Ferritin-like domain; Region: Ferritin; pfam00210 118163000031 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 118163000032 dinuclear metal binding motif [ion binding]; other site 118163000033 cobalt transport protein CbiM; Validated; Region: PRK06265 118163000034 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 118163000035 PDGLE domain; Region: PDGLE; pfam13190 118163000036 Cobalt transport protein; Region: CbiQ; cl00463 118163000037 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 118163000038 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 118163000039 Walker A/P-loop; other site 118163000040 ATP binding site [chemical binding]; other site 118163000041 Q-loop/lid; other site 118163000042 ABC transporter signature motif; other site 118163000043 Walker B; other site 118163000044 D-loop; other site 118163000045 H-loop/switch region; other site 118163000046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163000047 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 118163000048 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 118163000049 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 118163000050 putative substrate binding site [chemical binding]; other site 118163000051 putative ATP binding site [chemical binding]; other site 118163000052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163000053 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 118163000054 Coenzyme A binding pocket [chemical binding]; other site 118163000055 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 118163000056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163000057 catalytic loop [active] 118163000058 iron binding site [ion binding]; other site 118163000059 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 118163000060 FOG: CBS domain [General function prediction only]; Region: COG0517 118163000061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 118163000062 CP12 domain; Region: CP12; pfam02672 118163000063 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 118163000064 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 118163000065 2-phosphoglycerate kinase; Provisional; Region: PRK04220 118163000066 Mg chelatase-related protein; Region: TIGR00368 118163000067 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 118163000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163000069 Walker A motif; other site 118163000070 ATP binding site [chemical binding]; other site 118163000071 Walker B motif; other site 118163000072 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 118163000073 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163000074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163000075 active site 118163000076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163000077 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 118163000078 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 118163000079 putative tRNA-binding site [nucleotide binding]; other site 118163000080 B3/4 domain; Region: B3_4; pfam03483 118163000081 tRNA synthetase B5 domain; Region: B5; smart00874 118163000082 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 118163000083 dimer interface [polypeptide binding]; other site 118163000084 motif 1; other site 118163000085 motif 3; other site 118163000086 motif 2; other site 118163000087 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 118163000088 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 118163000089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163000090 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163000091 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 118163000092 Probable Catalytic site; other site 118163000093 metal-binding site 118163000094 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163000095 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 118163000096 Probable Catalytic site; other site 118163000097 metal-binding site 118163000098 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163000099 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 118163000100 Probable Catalytic site; other site 118163000101 metal-binding site 118163000102 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163000103 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 118163000104 Probable Catalytic site; other site 118163000105 metal-binding site 118163000106 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163000107 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 118163000108 Probable Catalytic site; other site 118163000109 metal-binding site 118163000110 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 118163000111 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 118163000112 Walker A/P-loop; other site 118163000113 ATP binding site [chemical binding]; other site 118163000114 Q-loop/lid; other site 118163000115 ABC transporter signature motif; other site 118163000116 Walker B; other site 118163000117 D-loop; other site 118163000118 H-loop/switch region; other site 118163000119 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 118163000120 putative carbohydrate binding site [chemical binding]; other site 118163000121 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 118163000122 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 118163000123 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 118163000124 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 118163000125 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 118163000126 P loop; other site 118163000127 Nucleotide binding site [chemical binding]; other site 118163000128 DTAP/Switch II; other site 118163000129 Switch I; other site 118163000130 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 118163000131 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163000132 PhoD-like phosphatase; Region: PhoD; pfam09423 118163000133 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 118163000134 putative active site [active] 118163000135 putative metal binding site [ion binding]; other site 118163000136 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 118163000137 Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514 118163000138 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 118163000139 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 118163000140 dimer interface [polypeptide binding]; other site 118163000141 decamer (pentamer of dimers) interface [polypeptide binding]; other site 118163000142 catalytic triad [active] 118163000143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163000144 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163000145 active site 118163000146 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 118163000147 substrate binding site; other site 118163000148 dimer interface; other site 118163000149 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 118163000150 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 118163000151 putative active site [active] 118163000152 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 118163000153 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 118163000154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163000155 FeS/SAM binding site; other site 118163000156 TRAM domain; Region: TRAM; pfam01938 118163000157 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 118163000158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163000159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163000160 catalytic residue [active] 118163000161 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 118163000162 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000163 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163000164 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000165 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163000166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000169 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163000170 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163000171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000173 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 118163000174 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 118163000175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 118163000176 non-specific DNA binding site [nucleotide binding]; other site 118163000177 salt bridge; other site 118163000178 sequence-specific DNA binding site [nucleotide binding]; other site 118163000179 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 118163000180 G1 box; other site 118163000181 GTP/Mg2+ binding site [chemical binding]; other site 118163000182 G3 box; other site 118163000183 Switch II region; other site 118163000184 G4 box; other site 118163000185 G5 box; other site 118163000186 Domain of unknown function (DUF697); Region: DUF697; pfam05128 118163000187 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 118163000188 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163000189 P-loop; other site 118163000190 Magnesium ion binding site [ion binding]; other site 118163000191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163000192 Magnesium ion binding site [ion binding]; other site 118163000193 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 118163000194 Fatty acid desaturase; Region: FA_desaturase; pfam00487 118163000195 Di-iron ligands [ion binding]; other site 118163000196 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 118163000197 Fatty acid desaturase; Region: FA_desaturase; pfam00487 118163000198 Di-iron ligands [ion binding]; other site 118163000199 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 118163000200 Aluminium resistance protein; Region: Alum_res; pfam06838 118163000201 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000202 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000203 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000204 GAF domain; Region: GAF; pfam01590 118163000205 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000206 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000208 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000211 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 118163000212 PBP superfamily domain; Region: PBP_like_2; pfam12849 118163000213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000214 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000215 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000216 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000218 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000219 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000220 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000221 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163000222 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163000223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163000224 dimer interface [polypeptide binding]; other site 118163000225 putative CheW interface [polypeptide binding]; other site 118163000226 CheW-like domain; Region: CheW; pfam01584 118163000227 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 118163000228 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 118163000229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 118163000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163000231 dimer interface [polypeptide binding]; other site 118163000232 conserved gate region; other site 118163000233 ABC-ATPase subunit interface; other site 118163000234 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 118163000235 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 118163000236 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 118163000237 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 118163000238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163000239 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163000240 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 118163000241 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163000242 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163000243 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 118163000244 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163000245 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163000246 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 118163000247 Uncharacterized conserved protein [Function unknown]; Region: COG1656 118163000248 Protein of unknown function DUF82; Region: DUF82; pfam01927 118163000249 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 118163000250 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 118163000251 active site 118163000252 Zn binding site [ion binding]; other site 118163000253 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 118163000254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163000255 FeS/SAM binding site; other site 118163000256 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 118163000257 active site 118163000258 dimer interface [polypeptide binding]; other site 118163000259 metal binding site [ion binding]; metal-binding site 118163000260 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 118163000261 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 118163000262 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 118163000263 generic binding surface II; other site 118163000264 generic binding surface I; other site 118163000265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163000266 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 118163000267 active site 118163000268 metal binding site [ion binding]; metal-binding site 118163000269 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 118163000270 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163000271 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 118163000272 catalytic triad [active] 118163000273 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 118163000274 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 118163000275 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 118163000276 alpha subunit interface [polypeptide binding]; other site 118163000277 TPP binding site [chemical binding]; other site 118163000278 heterodimer interface [polypeptide binding]; other site 118163000279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 118163000280 protein-export membrane protein SecD; Region: secD; TIGR01129 118163000281 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 118163000282 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 118163000283 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 118163000284 Protein export membrane protein; Region: SecD_SecF; pfam02355 118163000285 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 118163000286 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163000287 active site 118163000288 ATP binding site [chemical binding]; other site 118163000289 substrate binding site [chemical binding]; other site 118163000290 activation loop (A-loop); other site 118163000291 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 118163000292 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163000293 active site 118163000294 metal binding site [ion binding]; metal-binding site 118163000295 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 118163000296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 118163000297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 118163000298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 118163000299 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 118163000300 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 118163000301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163000302 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 118163000303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 118163000304 homodimer interface [polypeptide binding]; other site 118163000305 metal binding site [ion binding]; metal-binding site 118163000306 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 118163000307 homodimer interface [polypeptide binding]; other site 118163000308 active site 118163000309 putative chemical substrate binding site [chemical binding]; other site 118163000310 metal binding site [ion binding]; metal-binding site 118163000311 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 118163000312 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 118163000313 Catalytic site [active] 118163000314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163000315 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 118163000316 ligand binding site [chemical binding]; other site 118163000317 flexible hinge region; other site 118163000318 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 118163000319 putative switch regulator; other site 118163000320 non-specific DNA interactions [nucleotide binding]; other site 118163000321 DNA binding site [nucleotide binding] 118163000322 sequence specific DNA binding site [nucleotide binding]; other site 118163000323 putative cAMP binding site [chemical binding]; other site 118163000324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163000325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000326 active site 118163000327 phosphorylation site [posttranslational modification] 118163000328 intermolecular recognition site; other site 118163000329 dimerization interface [polypeptide binding]; other site 118163000330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163000331 DNA binding site [nucleotide binding] 118163000332 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163000333 putative binding surface; other site 118163000334 active site 118163000335 Response regulator receiver domain; Region: Response_reg; pfam00072 118163000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000337 active site 118163000338 phosphorylation site [posttranslational modification] 118163000339 intermolecular recognition site; other site 118163000340 dimerization interface [polypeptide binding]; other site 118163000341 Response regulator receiver domain; Region: Response_reg; pfam00072 118163000342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000343 active site 118163000344 phosphorylation site [posttranslational modification] 118163000345 intermolecular recognition site; other site 118163000346 dimerization interface [polypeptide binding]; other site 118163000347 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 118163000348 CpeS-like protein; Region: CpeS; pfam09367 118163000349 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 118163000350 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163000351 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163000352 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163000353 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163000354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163000355 Coenzyme A binding pocket [chemical binding]; other site 118163000356 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163000357 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 118163000358 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 118163000359 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 118163000360 Stage II sporulation protein; Region: SpoIID; pfam08486 118163000361 excinuclease ABC subunit B; Provisional; Region: PRK05298 118163000362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163000363 ATP binding site [chemical binding]; other site 118163000364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 118163000365 putative Mg++ binding site [ion binding]; other site 118163000366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163000367 nucleotide binding region [chemical binding]; other site 118163000368 ATP-binding site [chemical binding]; other site 118163000369 Ultra-violet resistance protein B; Region: UvrB; pfam12344 118163000370 UvrB/uvrC motif; Region: UVR; pfam02151 118163000371 cell division topological specificity factor MinE; Provisional; Region: PRK13988 118163000372 septum site-determining protein MinD; Region: minD_bact; TIGR01968 118163000373 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 118163000374 Switch I; other site 118163000375 Switch II; other site 118163000376 septum formation inhibitor; Reviewed; Region: minC; PRK00513 118163000377 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 118163000378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 118163000379 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163000380 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 118163000381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163000382 ligand binding site [chemical binding]; other site 118163000383 flexible hinge region; other site 118163000384 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 118163000385 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 118163000386 putative active site [active] 118163000387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163000388 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 118163000389 Walker A/P-loop; other site 118163000390 ATP binding site [chemical binding]; other site 118163000391 Q-loop/lid; other site 118163000392 ABC transporter signature motif; other site 118163000393 Walker B; other site 118163000394 D-loop; other site 118163000395 H-loop/switch region; other site 118163000396 Response regulator receiver domain; Region: Response_reg; pfam00072 118163000397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000398 active site 118163000399 phosphorylation site [posttranslational modification] 118163000400 intermolecular recognition site; other site 118163000401 dimerization interface [polypeptide binding]; other site 118163000402 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 118163000403 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 118163000404 carboxyltransferase (CT) interaction site; other site 118163000405 biotinylation site [posttranslational modification]; other site 118163000406 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163000407 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 118163000408 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 118163000409 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 118163000410 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163000411 TrkA-N domain; Region: TrkA_N; pfam02254 118163000412 TrkA-C domain; Region: TrkA_C; pfam02080 118163000413 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 118163000414 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 118163000415 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 118163000416 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 118163000417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 118163000418 RNA binding surface [nucleotide binding]; other site 118163000419 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 118163000420 active site 118163000421 Helix-turn-helix domain; Region: HTH_25; pfam13413 118163000422 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 118163000423 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 118163000424 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163000425 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 118163000426 chorismate binding enzyme; Region: Chorismate_bind; cl10555 118163000427 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 118163000428 ABC1 family; Region: ABC1; cl17513 118163000429 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 118163000430 Mechanosensitive ion channel; Region: MS_channel; pfam00924 118163000431 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 118163000432 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 118163000433 recombination protein RecR; Reviewed; Region: recR; PRK00076 118163000434 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 118163000435 RecR protein; Region: RecR; pfam02132 118163000436 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 118163000437 putative active site [active] 118163000438 putative metal-binding site [ion binding]; other site 118163000439 tetramer interface [polypeptide binding]; other site 118163000440 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 118163000441 protein I interface; other site 118163000442 D2 interface; other site 118163000443 protein T interface; other site 118163000444 chlorophyll binding site; other site 118163000445 beta carotene binding site; other site 118163000446 pheophytin binding site; other site 118163000447 manganese-stabilizing polypeptide interface; other site 118163000448 CP43 interface; other site 118163000449 protein L interface; other site 118163000450 oxygen evolving complex binding site; other site 118163000451 bromide binding site; other site 118163000452 quinone binding site; other site 118163000453 Fe binding site [ion binding]; other site 118163000454 core light harvesting interface; other site 118163000455 cytochrome b559 alpha subunit interface; other site 118163000456 cytochrome c-550 interface; other site 118163000457 protein J interface; other site 118163000458 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 118163000459 Bacterial Ig-like domain; Region: Big_5; pfam13205 118163000460 MG2 domain; Region: A2M_N; pfam01835 118163000461 Alpha-2-macroglobulin family; Region: A2M; pfam00207 118163000462 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 118163000463 surface patch; other site 118163000464 specificity defining residues; other site 118163000465 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 118163000466 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 118163000467 dimer interface [polypeptide binding]; other site 118163000468 anticodon binding site; other site 118163000469 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 118163000470 homodimer interface [polypeptide binding]; other site 118163000471 motif 1; other site 118163000472 active site 118163000473 motif 2; other site 118163000474 GAD domain; Region: GAD; pfam02938 118163000475 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 118163000476 active site 118163000477 motif 3; other site 118163000478 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 118163000479 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163000480 catalytic residues [active] 118163000481 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 118163000482 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 118163000483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163000484 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 118163000485 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 118163000486 NAD(P) binding site [chemical binding]; other site 118163000487 catalytic residues [active] 118163000488 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 118163000489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 118163000490 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 118163000491 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 118163000492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163000493 active site 118163000494 Haemolysin XhlA; Region: XhlA; pfam10779 118163000495 phytoene desaturase; Region: phytoene_desat; TIGR02731 118163000496 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163000497 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 118163000498 active site lid residues [active] 118163000499 substrate binding pocket [chemical binding]; other site 118163000500 catalytic residues [active] 118163000501 substrate-Mg2+ binding site; other site 118163000502 aspartate-rich region 1; other site 118163000503 aspartate-rich region 2; other site 118163000504 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 118163000505 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 118163000506 active site residue [active] 118163000507 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 118163000508 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 118163000509 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 118163000510 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 118163000511 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 118163000512 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 118163000513 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 118163000514 active site 118163000515 NTP binding site [chemical binding]; other site 118163000516 metal binding triad [ion binding]; metal-binding site 118163000517 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 118163000518 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 118163000519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163000520 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 118163000521 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 118163000522 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 118163000523 domain interfaces; other site 118163000524 active site 118163000525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163000526 catalytic core [active] 118163000527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163000528 phosphoglucomutase; Region: PLN02307 118163000529 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 118163000530 substrate binding site [chemical binding]; other site 118163000531 dimer interface [polypeptide binding]; other site 118163000532 active site 118163000533 metal binding site [ion binding]; metal-binding site 118163000534 Transglycosylase; Region: Transgly; pfam00912 118163000535 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 118163000536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 118163000537 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163000538 putative active site [active] 118163000539 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 118163000540 ribosomal protein L21; Region: rpl21; CHL00075 118163000541 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 118163000542 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 118163000543 proposed catalytic triad [active] 118163000544 active site nucleophile [active] 118163000545 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163000546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000547 heme pocket [chemical binding]; other site 118163000548 putative active site [active] 118163000549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000550 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163000551 putative active site [active] 118163000552 heme pocket [chemical binding]; other site 118163000553 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163000554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000555 putative active site [active] 118163000556 heme pocket [chemical binding]; other site 118163000557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000558 putative active site [active] 118163000559 heme pocket [chemical binding]; other site 118163000560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000561 PAS fold; Region: PAS_3; pfam08447 118163000562 putative active site [active] 118163000563 heme pocket [chemical binding]; other site 118163000564 PAS domain S-box; Region: sensory_box; TIGR00229 118163000565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000566 putative active site [active] 118163000567 heme pocket [chemical binding]; other site 118163000568 PAS domain S-box; Region: sensory_box; TIGR00229 118163000569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000570 putative active site [active] 118163000571 heme pocket [chemical binding]; other site 118163000572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163000573 dimer interface [polypeptide binding]; other site 118163000574 phosphorylation site [posttranslational modification] 118163000575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163000576 ATP binding site [chemical binding]; other site 118163000577 Mg2+ binding site [ion binding]; other site 118163000578 G-X-G motif; other site 118163000579 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 118163000580 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 118163000581 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 118163000582 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163000583 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163000584 active site 118163000585 ATP binding site [chemical binding]; other site 118163000586 substrate binding site [chemical binding]; other site 118163000587 activation loop (A-loop); other site 118163000588 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 118163000589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 118163000590 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 118163000591 putative dimerization interface [polypeptide binding]; other site 118163000592 Predicted membrane protein [Function unknown]; Region: COG4094 118163000593 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 118163000594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163000595 catalytic residues [active] 118163000596 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163000597 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 118163000598 Walker A/P-loop; other site 118163000599 ATP binding site [chemical binding]; other site 118163000600 Q-loop/lid; other site 118163000601 ABC transporter signature motif; other site 118163000602 Walker B; other site 118163000603 D-loop; other site 118163000604 H-loop/switch region; other site 118163000605 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 118163000606 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 118163000607 BON domain; Region: BON; pfam04972 118163000608 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 118163000609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 118163000610 ligand binding site [chemical binding]; other site 118163000611 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 118163000612 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 118163000613 Rab subfamily motif 1 (RabSF1); other site 118163000614 G1 box; other site 118163000615 GTP/Mg2+ binding site [chemical binding]; other site 118163000616 Rab subfamily motif 2 (RabSF2); other site 118163000617 Switch I region; other site 118163000618 G2 box; other site 118163000619 effector interaction site; other site 118163000620 GDI interaction site; other site 118163000621 Rab family motif 1 (RabF1); other site 118163000622 GEF interaction site [polypeptide binding]; other site 118163000623 Rab family motif 2 (RabF2); other site 118163000624 G3 box; other site 118163000625 Switch II region; other site 118163000626 Rab family motif 3 (RabF3); other site 118163000627 Rab family motif 4 (RabF4); other site 118163000628 Rab family motif 5 (RabF5); other site 118163000629 Rab subfamily motif 3 (RabSF3); other site 118163000630 G4 box; other site 118163000631 G5 box; other site 118163000632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 118163000633 FOG: CBS domain [General function prediction only]; Region: COG0517 118163000634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163000635 PAS fold; Region: PAS_3; pfam08447 118163000636 putative active site [active] 118163000637 heme pocket [chemical binding]; other site 118163000638 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163000639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163000640 metal binding site [ion binding]; metal-binding site 118163000641 active site 118163000642 I-site; other site 118163000643 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163000644 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 118163000645 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 118163000646 transmembrane helices; other site 118163000647 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 118163000648 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163000649 putative active site [active] 118163000650 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 118163000651 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 118163000652 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 118163000653 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 118163000654 glycogen binding site [chemical binding]; other site 118163000655 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 118163000656 active site 118163000657 catalytic site [active] 118163000658 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 118163000659 Predicted membrane protein [Function unknown]; Region: COG1950 118163000660 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 118163000661 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 118163000662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 118163000663 active site residue [active] 118163000664 FAD dependent oxidoreductase; Region: DAO; pfam01266 118163000665 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 118163000666 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 118163000667 iron-sulfur cluster [ion binding]; other site 118163000668 heat shock protein HtpX; Provisional; Region: PRK03982 118163000669 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 118163000670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163000671 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 118163000672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163000673 Late competence development protein ComFB; Region: ComFB; pfam10719 118163000674 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 118163000675 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 118163000676 Probable Catalytic site; other site 118163000677 Uncharacterized conserved protein [Function unknown]; Region: COG0398 118163000678 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 118163000679 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 118163000680 nitrite reductase subunit NirD; Provisional; Region: PRK14989 118163000681 mercuric reductase; Validated; Region: PRK06370 118163000682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163000683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163000684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 118163000685 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 118163000686 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163000687 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 118163000688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163000689 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 118163000690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 118163000691 SNF2 Helicase protein; Region: DUF3670; pfam12419 118163000692 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 118163000693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163000694 ATP binding site [chemical binding]; other site 118163000695 putative Mg++ binding site [ion binding]; other site 118163000696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163000697 nucleotide binding region [chemical binding]; other site 118163000698 ATP-binding site [chemical binding]; other site 118163000699 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 118163000700 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 118163000701 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 118163000702 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 118163000703 Response regulator receiver domain; Region: Response_reg; pfam00072 118163000704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000705 active site 118163000706 phosphorylation site [posttranslational modification] 118163000707 intermolecular recognition site; other site 118163000708 dimerization interface [polypeptide binding]; other site 118163000709 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163000710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163000711 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163000712 Beta-propeller repeat; Region: SBBP; pfam06739 118163000713 Beta-propeller repeat; Region: SBBP; pfam06739 118163000714 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163000715 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 118163000716 active site 118163000717 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 118163000718 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 118163000719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163000720 catalytic residue [active] 118163000721 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 118163000722 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 118163000723 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 118163000724 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 118163000725 NAD binding site [chemical binding]; other site 118163000726 homodimer interface [polypeptide binding]; other site 118163000727 active site 118163000728 substrate binding site [chemical binding]; other site 118163000729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 118163000730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163000731 putative substrate translocation pore; other site 118163000732 monogalactosyldiacylglycerol synthase; Region: PLN02605 118163000733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163000734 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 118163000735 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 118163000736 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 118163000737 classical (c) SDRs; Region: SDR_c; cd05233 118163000738 NAD(P) binding site [chemical binding]; other site 118163000739 active site 118163000740 monogalactosyldiacylglycerol synthase; Region: PLN02605 118163000741 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 118163000742 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163000743 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163000744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163000745 NAD(P) binding site [chemical binding]; other site 118163000746 active site 118163000747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163000748 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 118163000749 active site 118163000750 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 118163000751 Acyl transferase domain; Region: Acyl_transf_1; cl08282 118163000752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163000753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163000754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 118163000755 active site 118163000756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 118163000757 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 118163000758 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 118163000759 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 118163000760 putative NADP binding site [chemical binding]; other site 118163000761 active site 118163000762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163000763 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163000764 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 118163000765 Fatty acid desaturase; Region: FA_desaturase; pfam00487 118163000766 Di-iron ligands [ion binding]; other site 118163000767 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 118163000768 acyl-CoA synthetase; Validated; Region: PRK05850 118163000769 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163000770 acyl-activating enzyme (AAE) consensus motif; other site 118163000771 active site 118163000772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163000773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163000774 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 118163000775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 118163000777 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 118163000778 O-Antigen ligase; Region: Wzy_C; pfam04932 118163000779 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000780 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163000781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163000784 replicative DNA helicase; Region: DnaB; TIGR00665 118163000785 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 118163000786 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 118163000787 Walker A motif; other site 118163000788 ATP binding site [chemical binding]; other site 118163000789 Walker B motif; other site 118163000790 DNA binding loops [nucleotide binding] 118163000791 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163000792 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 118163000793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163000794 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 118163000795 DXD motif; other site 118163000796 PilZ domain; Region: PilZ; pfam07238 118163000797 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 118163000798 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 118163000799 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 118163000800 substrate binding pocket [chemical binding]; other site 118163000801 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 118163000802 B12 binding site [chemical binding]; other site 118163000803 cobalt ligand [ion binding]; other site 118163000804 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 118163000805 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 118163000806 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 118163000807 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 118163000808 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 118163000809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163000810 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 118163000811 Walker A motif; other site 118163000812 ATP binding site [chemical binding]; other site 118163000813 Walker B motif; other site 118163000814 arginine finger; other site 118163000815 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 118163000816 metal ion-dependent adhesion site (MIDAS); other site 118163000817 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 118163000818 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163000819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163000820 TPR motif; other site 118163000821 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 118163000822 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 118163000823 Resolvase, N terminal domain; Region: Resolvase; smart00857 118163000824 catalytic residues [active] 118163000825 Recombinase; Region: Recombinase; pfam07508 118163000826 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 118163000827 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 118163000828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163000829 dimer interface [polypeptide binding]; other site 118163000830 putative metal binding site [ion binding]; other site 118163000831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 118163000832 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 118163000833 ribosome recycling factor; Reviewed; Region: frr; PRK00083 118163000834 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 118163000835 hinge region; other site 118163000836 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 118163000837 putative nucleotide binding site [chemical binding]; other site 118163000838 uridine monophosphate binding site [chemical binding]; other site 118163000839 homohexameric interface [polypeptide binding]; other site 118163000840 agmatinase; Region: agmatinase; TIGR01230 118163000841 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 118163000842 putative active site [active] 118163000843 Mn binding site [ion binding]; other site 118163000844 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 118163000845 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 118163000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163000847 dimer interface [polypeptide binding]; other site 118163000848 conserved gate region; other site 118163000849 putative PBP binding loops; other site 118163000850 ABC-ATPase subunit interface; other site 118163000851 acyl-CoA synthetase; Validated; Region: PRK05850 118163000852 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163000853 acyl-activating enzyme (AAE) consensus motif; other site 118163000854 active site 118163000855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 118163000856 ribonuclease III; Reviewed; Region: rnc; PRK00102 118163000857 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 118163000858 dimerization interface [polypeptide binding]; other site 118163000859 active site 118163000860 metal binding site [ion binding]; metal-binding site 118163000861 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 118163000862 dsRNA binding site [nucleotide binding]; other site 118163000863 TPR repeat; Region: TPR_11; pfam13414 118163000864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163000865 binding surface 118163000866 TPR motif; other site 118163000867 TPR repeat; Region: TPR_11; pfam13414 118163000868 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 118163000869 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 118163000870 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 118163000871 Protein of unknown function (DUF751); Region: DUF751; pfam05421 118163000872 aspartate kinase; Provisional; Region: PRK07431 118163000873 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 118163000874 putative catalytic residues [active] 118163000875 putative nucleotide binding site [chemical binding]; other site 118163000876 putative aspartate binding site [chemical binding]; other site 118163000877 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 118163000878 putative allosteric regulatory site; other site 118163000879 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 118163000880 putative allosteric regulatory residue; other site 118163000881 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 118163000882 putative allosteric regulatory site; other site 118163000883 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 118163000884 putative allosteric regulatory residue; other site 118163000885 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 118163000886 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 118163000887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163000888 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 118163000889 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 118163000890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163000891 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163000892 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163000893 Hexamer interface [polypeptide binding]; other site 118163000894 Hexagonal pore residue; other site 118163000895 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163000896 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163000897 Hexamer interface [polypeptide binding]; other site 118163000898 Hexagonal pore residue; other site 118163000899 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 118163000900 Hexamer/Pentamer interface [polypeptide binding]; other site 118163000901 central pore; other site 118163000902 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 118163000903 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 118163000904 trimer interface [polypeptide binding]; other site 118163000905 active site 118163000906 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 118163000907 putative multimerization interface [polypeptide binding]; other site 118163000908 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 118163000909 putative multimerization interface [polypeptide binding]; other site 118163000910 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 118163000911 putative multimerization interface [polypeptide binding]; other site 118163000912 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 118163000913 putative multimerization interface [polypeptide binding]; other site 118163000914 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 118163000915 putative trimer interface [polypeptide binding]; other site 118163000916 putative CoA binding site [chemical binding]; other site 118163000917 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 118163000918 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 118163000919 homodimer interface [polypeptide binding]; other site 118163000920 active site 118163000921 heterodimer interface [polypeptide binding]; other site 118163000922 catalytic residue [active] 118163000923 metal binding site [ion binding]; metal-binding site 118163000924 RbcX protein; Region: RcbX; pfam02341 118163000925 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 118163000926 multimerization interface [polypeptide binding]; other site 118163000927 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 118163000928 catalytic motif [active] 118163000929 Catalytic residue [active] 118163000930 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 118163000931 nucleotide binding site/active site [active] 118163000932 HIT family signature motif; other site 118163000933 catalytic residue [active] 118163000934 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 118163000935 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 118163000936 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 118163000937 active site 118163000938 catalytic site [active] 118163000939 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 118163000940 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 118163000941 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 118163000942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163000943 S-adenosylmethionine binding site [chemical binding]; other site 118163000944 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 118163000945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163000946 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163000947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163000948 DNA binding residues [nucleotide binding] 118163000949 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 118163000950 intracellular protease, PfpI family; Region: PfpI; TIGR01382 118163000951 conserved cys residue [active] 118163000952 Protein required for attachment to host cells; Region: Host_attach; pfam10116 118163000953 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 118163000954 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 118163000955 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 118163000956 alpha subunit interaction interface [polypeptide binding]; other site 118163000957 Walker A motif; other site 118163000958 ATP binding site [chemical binding]; other site 118163000959 Walker B motif; other site 118163000960 inhibitor binding site; inhibition site 118163000961 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 118163000962 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 118163000963 gamma subunit interface [polypeptide binding]; other site 118163000964 epsilon subunit interface [polypeptide binding]; other site 118163000965 LBP interface [polypeptide binding]; other site 118163000966 calcium/proton exchanger (cax); Region: cax; TIGR00378 118163000967 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163000968 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 118163000969 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163000970 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 118163000971 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 118163000972 putative active site [active] 118163000973 catalytic residue [active] 118163000974 hypothetical protein; Provisional; Region: PRK02724 118163000975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163000976 dimer interface [polypeptide binding]; other site 118163000977 phosphorylation site [posttranslational modification] 118163000978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163000979 ATP binding site [chemical binding]; other site 118163000980 Mg2+ binding site [ion binding]; other site 118163000981 G-X-G motif; other site 118163000982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163000983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000984 active site 118163000985 phosphorylation site [posttranslational modification] 118163000986 intermolecular recognition site; other site 118163000987 dimerization interface [polypeptide binding]; other site 118163000988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163000989 DNA binding site [nucleotide binding] 118163000990 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163000991 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163000992 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 118163000993 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 118163000994 putative dimer interface [polypeptide binding]; other site 118163000995 Response regulator receiver domain; Region: Response_reg; pfam00072 118163000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163000997 active site 118163000998 phosphorylation site [posttranslational modification] 118163000999 intermolecular recognition site; other site 118163001000 dimerization interface [polypeptide binding]; other site 118163001001 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 118163001002 CsbD-like; Region: CsbD; pfam05532 118163001003 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 118163001004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163001005 active site 118163001006 motif I; other site 118163001007 motif II; other site 118163001008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163001009 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163001010 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 118163001011 active site 118163001012 Protein of unknown function DUF72; Region: DUF72; pfam01904 118163001013 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163001014 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 118163001015 NlpC/P60 family; Region: NLPC_P60; pfam00877 118163001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 118163001017 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 118163001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163001019 ABC-ATPase subunit interface; other site 118163001020 putative PBP binding loops; other site 118163001021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163001022 dimer interface [polypeptide binding]; other site 118163001023 conserved gate region; other site 118163001024 putative PBP binding loops; other site 118163001025 ABC-ATPase subunit interface; other site 118163001026 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 118163001027 putative dimer interface [polypeptide binding]; other site 118163001028 active site pocket [active] 118163001029 putative cataytic base [active] 118163001030 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 118163001031 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 118163001032 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 118163001033 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 118163001034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163001035 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 118163001036 acyl-activating enzyme (AAE) consensus motif; other site 118163001037 acyl-activating enzyme (AAE) consensus motif; other site 118163001038 putative AMP binding site [chemical binding]; other site 118163001039 putative active site [active] 118163001040 putative CoA binding site [chemical binding]; other site 118163001041 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 118163001042 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 118163001043 nucleotide binding site [chemical binding]; other site 118163001044 NEF interaction site [polypeptide binding]; other site 118163001045 SBD interface [polypeptide binding]; other site 118163001046 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 118163001047 four helix bundle protein; Region: TIGR02436 118163001048 Domain of unknown function (DUF427); Region: DUF427; cl00998 118163001049 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 118163001050 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 118163001051 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 118163001052 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 118163001053 SOS regulatory protein LexA; Region: lexA; TIGR00498 118163001054 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 118163001055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 118163001056 Catalytic site [active] 118163001057 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 118163001058 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 118163001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 118163001060 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 118163001061 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 118163001062 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 118163001063 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 118163001064 antiporter inner membrane protein; Provisional; Region: PRK11670 118163001065 Domain of unknown function DUF59; Region: DUF59; pfam01883 118163001066 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 118163001067 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 118163001068 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 118163001069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163001070 active site 118163001071 motif I; other site 118163001072 motif II; other site 118163001073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163001074 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 118163001075 active site 118163001076 multimer interface [polypeptide binding]; other site 118163001077 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 118163001078 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 118163001079 active site 118163001080 nucleophile elbow; other site 118163001081 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 118163001082 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 118163001083 Mg++ binding site [ion binding]; other site 118163001084 putative catalytic motif [active] 118163001085 putative substrate binding site [chemical binding]; other site 118163001086 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 118163001087 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 118163001088 Peptidase family M48; Region: Peptidase_M48; cl12018 118163001089 FtsH Extracellular; Region: FtsH_ext; pfam06480 118163001090 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 118163001091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163001092 Walker A motif; other site 118163001093 ATP binding site [chemical binding]; other site 118163001094 Walker B motif; other site 118163001095 arginine finger; other site 118163001096 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163001097 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 118163001098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163001099 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 118163001100 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 118163001101 hypothetical protein; Reviewed; Region: PRK09588 118163001102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 118163001103 alanine racemase; Reviewed; Region: alr; PRK00053 118163001104 active site 118163001105 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 118163001106 dimer interface [polypeptide binding]; other site 118163001107 substrate binding site [chemical binding]; other site 118163001108 catalytic residues [active] 118163001109 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 118163001110 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 118163001111 Uncharacterized conserved protein [Function unknown]; Region: COG1615 118163001112 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 118163001113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163001114 active site 118163001115 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 118163001116 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 118163001117 30S subunit binding site; other site 118163001118 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 118163001119 RNA-binding motif; other site 118163001120 DNA-binding site [nucleotide binding]; DNA binding site 118163001121 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 118163001122 DDE superfamily endonuclease; Region: DDE_3; pfam13358 118163001123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 118163001124 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 118163001125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163001126 Walker A motif; other site 118163001127 ATP binding site [chemical binding]; other site 118163001128 Walker B motif; other site 118163001129 Uncharacterized conserved protein [Function unknown]; Region: COG4274 118163001130 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 118163001131 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 118163001132 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 118163001133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163001134 FeS/SAM binding site; other site 118163001135 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 118163001136 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 118163001137 CoA binding domain; Region: CoA_binding_2; pfam13380 118163001138 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 118163001139 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 118163001140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 118163001141 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 118163001142 EamA-like transporter family; Region: EamA; pfam00892 118163001143 EamA-like transporter family; Region: EamA; pfam00892 118163001144 FtsH Extracellular; Region: FtsH_ext; pfam06480 118163001145 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 118163001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163001147 Walker A motif; other site 118163001148 ATP binding site [chemical binding]; other site 118163001149 Walker B motif; other site 118163001150 arginine finger; other site 118163001151 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163001152 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 118163001153 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 118163001154 nucleotide binding site [chemical binding]; other site 118163001155 NEF interaction site [polypeptide binding]; other site 118163001156 SBD interface [polypeptide binding]; other site 118163001157 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 118163001158 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 118163001159 putative dimer interface [polypeptide binding]; other site 118163001160 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 118163001161 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 118163001162 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 118163001163 dimer interface [polypeptide binding]; other site 118163001164 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 118163001165 active site 118163001166 Fe binding site [ion binding]; other site 118163001167 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 118163001168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163001169 putative DNA binding site [nucleotide binding]; other site 118163001170 putative Zn2+ binding site [ion binding]; other site 118163001171 AsnC family; Region: AsnC_trans_reg; pfam01037 118163001172 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163001173 putative active site [active] 118163001174 fumarylacetoacetase; Region: PLN02856 118163001175 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 118163001176 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 118163001177 aspartate aminotransferase; Provisional; Region: PRK05764 118163001178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163001179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163001180 homodimer interface [polypeptide binding]; other site 118163001181 catalytic residue [active] 118163001182 magnesium transport protein MgtC; Provisional; Region: PRK15385 118163001183 MgtC family; Region: MgtC; pfam02308 118163001184 TPR repeat; Region: TPR_11; pfam13414 118163001185 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 118163001186 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 118163001187 putative ligand binding site [chemical binding]; other site 118163001188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163001189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 118163001190 putative substrate translocation pore; other site 118163001191 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 118163001192 active site 118163001193 iron coordination sites [ion binding]; other site 118163001194 substrate binding pocket [chemical binding]; other site 118163001195 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 118163001196 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 118163001197 putative ligand binding site [chemical binding]; other site 118163001198 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163001199 putative binding surface; other site 118163001200 active site 118163001201 CheW-like domain; Region: CheW; pfam01584 118163001202 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163001203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001204 active site 118163001205 phosphorylation site [posttranslational modification] 118163001206 intermolecular recognition site; other site 118163001207 dimerization interface [polypeptide binding]; other site 118163001208 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163001209 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163001210 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163001211 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163001212 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163001213 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163001214 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163001215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163001216 dimer interface [polypeptide binding]; other site 118163001217 putative CheW interface [polypeptide binding]; other site 118163001218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163001219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163001220 active site 118163001221 ATP binding site [chemical binding]; other site 118163001222 substrate binding site [chemical binding]; other site 118163001223 activation loop (A-loop); other site 118163001224 GUN4-like; Region: GUN4; pfam05419 118163001225 Uncharacterized conserved protein [Function unknown]; Region: COG1565 118163001226 putative phosphate acyltransferase; Provisional; Region: PRK05331 118163001227 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 118163001228 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 118163001229 dimer interface [polypeptide binding]; other site 118163001230 active site 118163001231 CoA binding pocket [chemical binding]; other site 118163001232 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 118163001233 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 118163001234 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163001235 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001236 Predicted flavoprotein [General function prediction only]; Region: COG0431 118163001237 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 118163001238 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 118163001239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 118163001240 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 118163001241 Protein of unknown function (DUF721); Region: DUF721; cl02324 118163001242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 118163001243 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 118163001244 substrate binding site [chemical binding]; other site 118163001245 oxyanion hole (OAH) forming residues; other site 118163001246 trimer interface [polypeptide binding]; other site 118163001247 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 118163001248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163001249 FeS/SAM binding site; other site 118163001250 ATP-grasp domain; Region: ATP-grasp_4; cl17255 118163001251 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 118163001252 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 118163001253 iron-sulfur cluster [ion binding]; other site 118163001254 [2Fe-2S] cluster binding site [ion binding]; other site 118163001255 Rubrerythrin [Energy production and conversion]; Region: COG1592 118163001256 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 118163001257 binuclear metal center [ion binding]; other site 118163001258 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 118163001259 Uncharacterized conserved protein [Function unknown]; Region: COG2442 118163001260 Response regulator receiver domain; Region: Response_reg; pfam00072 118163001261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001262 active site 118163001263 phosphorylation site [posttranslational modification] 118163001264 intermolecular recognition site; other site 118163001265 dimerization interface [polypeptide binding]; other site 118163001266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163001267 DNA binding site [nucleotide binding] 118163001268 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 118163001269 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 118163001270 MutS domain III; Region: MutS_III; pfam05192 118163001271 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 118163001272 Walker A/P-loop; other site 118163001273 ATP binding site [chemical binding]; other site 118163001274 Q-loop/lid; other site 118163001275 ABC transporter signature motif; other site 118163001276 Walker B; other site 118163001277 D-loop; other site 118163001278 H-loop/switch region; other site 118163001279 Smr domain; Region: Smr; pfam01713 118163001280 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 118163001281 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 118163001282 active site 118163001283 active pocket/dimerization site; other site 118163001284 phosphorylation site [posttranslational modification] 118163001285 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 118163001286 dimerization domain swap beta strand [polypeptide binding]; other site 118163001287 regulatory protein interface [polypeptide binding]; other site 118163001288 active site 118163001289 regulatory phosphorylation site [posttranslational modification]; other site 118163001290 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 118163001291 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 118163001292 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 118163001293 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 118163001294 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163001295 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163001296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 118163001297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 118163001298 substrate binding pocket [chemical binding]; other site 118163001299 membrane-bound complex binding site; other site 118163001300 hinge residues; other site 118163001301 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163001302 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 118163001303 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 118163001304 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 118163001305 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 118163001306 UGMP family protein; Validated; Region: PRK09604 118163001307 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 118163001308 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 118163001309 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 118163001310 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 118163001311 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 118163001312 YwiC-like protein; Region: YwiC; pfam14256 118163001313 hydrolase, alpha/beta fold family protein; Region: PLN02824 118163001314 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163001315 2TM domain; Region: 2TM; pfam13239 118163001316 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 118163001317 Domain of unknown function DUF21; Region: DUF21; pfam01595 118163001318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 118163001319 Transporter associated domain; Region: CorC_HlyC; smart01091 118163001320 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163001321 Ligand Binding Site [chemical binding]; other site 118163001322 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163001323 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001324 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001325 SnoaL-like domain; Region: SnoaL_2; pfam12680 118163001326 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 118163001327 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163001328 catalytic core [active] 118163001329 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 118163001330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163001331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163001332 Walker A/P-loop; other site 118163001333 ATP binding site [chemical binding]; other site 118163001334 Q-loop/lid; other site 118163001335 ABC transporter signature motif; other site 118163001336 Walker B; other site 118163001337 D-loop; other site 118163001338 H-loop/switch region; other site 118163001339 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 118163001340 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 118163001341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163001342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163001343 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 118163001344 Walker A/P-loop; other site 118163001345 ATP binding site [chemical binding]; other site 118163001346 Q-loop/lid; other site 118163001347 ABC transporter signature motif; other site 118163001348 Walker B; other site 118163001349 D-loop; other site 118163001350 H-loop/switch region; other site 118163001351 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 118163001352 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 118163001353 ring oligomerisation interface [polypeptide binding]; other site 118163001354 ATP/Mg binding site [chemical binding]; other site 118163001355 stacking interactions; other site 118163001356 hinge regions; other site 118163001357 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 118163001358 oligomerisation interface [polypeptide binding]; other site 118163001359 mobile loop; other site 118163001360 roof hairpin; other site 118163001361 Domain of unknown function DUF29; Region: DUF29; pfam01724 118163001362 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 118163001363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163001364 YGGT family; Region: YGGT; pfam02325 118163001365 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163001366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163001367 S-adenosylmethionine binding site [chemical binding]; other site 118163001368 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 118163001369 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 118163001370 Family of unknown function (DUF490); Region: DUF490; pfam04357 118163001371 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 118163001372 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 118163001373 DXD motif; other site 118163001374 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 118163001375 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 118163001376 short chain dehydrogenase; Provisional; Region: PRK12367 118163001377 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 118163001378 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 118163001379 active site 118163001380 TDP-binding site; other site 118163001381 acceptor substrate-binding pocket; other site 118163001382 homodimer interface [polypeptide binding]; other site 118163001383 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 118163001384 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 118163001385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163001386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163001387 homodimer interface [polypeptide binding]; other site 118163001388 catalytic residue [active] 118163001389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 118163001390 catalytic residues [active] 118163001391 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 118163001392 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 118163001393 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 118163001394 signal recognition particle protein; Provisional; Region: PRK10867 118163001395 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 118163001396 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 118163001397 P loop; other site 118163001398 GTP binding site [chemical binding]; other site 118163001399 Signal peptide binding domain; Region: SRP_SPB; pfam02978 118163001400 Predicted permeases [General function prediction only]; Region: COG0795 118163001401 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 118163001402 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 118163001403 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 118163001404 Walker A/P-loop; other site 118163001405 ATP binding site [chemical binding]; other site 118163001406 Q-loop/lid; other site 118163001407 ABC transporter signature motif; other site 118163001408 Walker B; other site 118163001409 D-loop; other site 118163001410 H-loop/switch region; other site 118163001411 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 118163001412 OstA-like protein; Region: OstA; pfam03968 118163001413 Domain of unknown function (DUF309); Region: DUF309; pfam03745 118163001414 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 118163001415 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 118163001416 comF family protein; Region: comF; TIGR00201 118163001417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163001418 active site 118163001419 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 118163001420 Predicted GTPase [General function prediction only]; Region: COG3596 118163001421 YfjP GTPase; Region: YfjP; cd11383 118163001422 G1 box; other site 118163001423 GTP/Mg2+ binding site [chemical binding]; other site 118163001424 Switch I region; other site 118163001425 G2 box; other site 118163001426 Switch II region; other site 118163001427 G3 box; other site 118163001428 G4 box; other site 118163001429 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 118163001430 tartrate dehydrogenase; Region: TTC; TIGR02089 118163001431 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 118163001432 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163001433 30S ribosomal protein S1; Reviewed; Region: PRK07400 118163001434 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 118163001435 RNA binding site [nucleotide binding]; other site 118163001436 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 118163001437 RNA binding site [nucleotide binding]; other site 118163001438 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 118163001439 RNA binding site [nucleotide binding]; other site 118163001440 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 118163001441 active site clefts [active] 118163001442 zinc binding site [ion binding]; other site 118163001443 dimer interface [polypeptide binding]; other site 118163001444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001445 binding surface 118163001446 TPR motif; other site 118163001447 TPR repeat; Region: TPR_11; pfam13414 118163001448 TPR repeat; Region: TPR_11; pfam13414 118163001449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001450 binding surface 118163001451 TPR motif; other site 118163001452 Pirin-related protein [General function prediction only]; Region: COG1741 118163001453 Pirin; Region: Pirin; pfam02678 118163001454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163001455 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 118163001456 Probable transposase; Region: OrfB_IS605; pfam01385 118163001457 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163001458 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 118163001459 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 118163001460 Probable Catalytic site; other site 118163001461 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163001462 putative active site [active] 118163001463 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 118163001464 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 118163001465 homodimer interface [polypeptide binding]; other site 118163001466 substrate-cofactor binding pocket; other site 118163001467 catalytic residue [active] 118163001468 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 118163001469 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 118163001470 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 118163001471 protein binding site [polypeptide binding]; other site 118163001472 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163001473 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163001474 ligand binding site [chemical binding]; other site 118163001475 flexible hinge region; other site 118163001476 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 118163001477 putative switch regulator; other site 118163001478 non-specific DNA interactions [nucleotide binding]; other site 118163001479 DNA binding site [nucleotide binding] 118163001480 sequence specific DNA binding site [nucleotide binding]; other site 118163001481 putative cAMP binding site [chemical binding]; other site 118163001482 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163001483 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 118163001484 Walker A/P-loop; other site 118163001485 ATP binding site [chemical binding]; other site 118163001486 Q-loop/lid; other site 118163001487 ABC transporter signature motif; other site 118163001488 Walker B; other site 118163001489 D-loop; other site 118163001490 H-loop/switch region; other site 118163001491 Uncharacterized conserved protein [Function unknown]; Region: COG4095 118163001492 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 118163001493 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 118163001494 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 118163001495 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 118163001496 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 118163001497 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 118163001498 metal ion-dependent adhesion site (MIDAS); other site 118163001499 MarR family; Region: MarR_2; pfam12802 118163001500 hypothetical protein; Validated; Region: PRK07411 118163001501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 118163001502 ATP binding site [chemical binding]; other site 118163001503 substrate interface [chemical binding]; other site 118163001504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 118163001505 active site residue [active] 118163001506 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163001507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163001508 S-adenosylmethionine binding site [chemical binding]; other site 118163001509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 118163001510 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 118163001511 MPN+ (JAMM) motif; other site 118163001512 Zinc-binding site [ion binding]; other site 118163001513 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 118163001514 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 118163001515 Walker A/P-loop; other site 118163001516 ATP binding site [chemical binding]; other site 118163001517 Q-loop/lid; other site 118163001518 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 118163001519 ABC transporter signature motif; other site 118163001520 Walker B; other site 118163001521 D-loop; other site 118163001522 H-loop/switch region; other site 118163001523 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 118163001524 ABC1 family; Region: ABC1; pfam03109 118163001525 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 118163001526 active site 118163001527 ATP binding site [chemical binding]; other site 118163001528 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 118163001529 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163001530 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163001531 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 118163001532 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 118163001533 AAA domain; Region: AAA_13; pfam13166 118163001534 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 118163001535 dimerization interface [polypeptide binding]; other site 118163001536 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 118163001537 ATP binding site [chemical binding]; other site 118163001538 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163001539 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163001540 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 118163001541 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 118163001542 putative NADP binding site [chemical binding]; other site 118163001543 putative substrate binding site [chemical binding]; other site 118163001544 active site 118163001545 Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152 118163001546 pheophytin binding site; other site 118163001547 chlorophyll binding site; other site 118163001548 quinone binding site; other site 118163001549 Fe binding site [ion binding]; other site 118163001550 hypothetical protein; Provisional; Region: PRK13683 118163001551 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 118163001552 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 118163001553 Walker A/P-loop; other site 118163001554 ATP binding site [chemical binding]; other site 118163001555 Q-loop/lid; other site 118163001556 ABC transporter signature motif; other site 118163001557 Walker B; other site 118163001558 D-loop; other site 118163001559 H-loop/switch region; other site 118163001560 YacP-like NYN domain; Region: NYN_YacP; pfam05991 118163001561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163001562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163001563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163001564 Walker A/P-loop; other site 118163001565 ATP binding site [chemical binding]; other site 118163001566 Q-loop/lid; other site 118163001567 ABC transporter signature motif; other site 118163001568 Walker B; other site 118163001569 D-loop; other site 118163001570 H-loop/switch region; other site 118163001571 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 118163001572 CoA binding domain; Region: CoA_binding; cl17356 118163001573 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 118163001574 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 118163001575 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 118163001576 O-Antigen ligase; Region: Wzy_C; pfam04932 118163001577 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 118163001578 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 118163001579 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 118163001580 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 118163001581 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 118163001582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 118163001583 Protein of unknown function (DUF433); Region: DUF433; pfam04255 118163001584 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 118163001585 O-Antigen ligase; Region: Wzy_C; pfam04932 118163001586 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 118163001587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001588 TPR motif; other site 118163001589 binding surface 118163001590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 118163001591 D-xylulose kinase; Region: XylB; TIGR01312 118163001592 nucleotide binding site [chemical binding]; other site 118163001593 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 118163001594 nudix motif; other site 118163001595 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 118163001596 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 118163001597 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 118163001598 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163001599 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 118163001600 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 118163001601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163001602 ATP binding site [chemical binding]; other site 118163001603 Mg2+ binding site [ion binding]; other site 118163001604 G-X-G motif; other site 118163001605 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 118163001606 ATP binding site [chemical binding]; other site 118163001607 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 118163001608 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 118163001609 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163001610 GAF domain; Region: GAF; pfam01590 118163001611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163001612 dimer interface [polypeptide binding]; other site 118163001613 phosphorylation site [posttranslational modification] 118163001614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163001615 ATP binding site [chemical binding]; other site 118163001616 Mg2+ binding site [ion binding]; other site 118163001617 G-X-G motif; other site 118163001618 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 118163001619 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 118163001620 lipoyl synthase; Provisional; Region: PRK12928 118163001621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163001622 FeS/SAM binding site; other site 118163001623 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001625 active site 118163001626 phosphorylation site [posttranslational modification] 118163001627 intermolecular recognition site; other site 118163001628 dimerization interface [polypeptide binding]; other site 118163001629 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 118163001630 MPT binding site; other site 118163001631 trimer interface [polypeptide binding]; other site 118163001632 Psb28 protein; Region: Psb28; cl04326 118163001633 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 118163001634 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 118163001635 active site 118163001636 substrate binding site [chemical binding]; other site 118163001637 metal binding site [ion binding]; metal-binding site 118163001638 light-harvesting-like protein 3; Provisional; Region: PLN00014 118163001639 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 118163001640 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 118163001641 DNA binding residues [nucleotide binding] 118163001642 dimer interface [polypeptide binding]; other site 118163001643 metal binding site [ion binding]; metal-binding site 118163001644 PQQ-like domain; Region: PQQ_2; pfam13360 118163001645 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163001646 structural tetrad; other site 118163001647 Uncharacterized conserved protein [Function unknown]; Region: COG0062 118163001648 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 118163001649 putative substrate binding site [chemical binding]; other site 118163001650 putative ATP binding site [chemical binding]; other site 118163001651 4Fe-4S binding domain; Region: Fer4; pfam00037 118163001652 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 118163001653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 118163001654 non-specific DNA binding site [nucleotide binding]; other site 118163001655 salt bridge; other site 118163001656 sequence-specific DNA binding site [nucleotide binding]; other site 118163001657 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 118163001658 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 118163001659 30S subunit binding site; other site 118163001660 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 118163001661 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 118163001662 dimer interface [polypeptide binding]; other site 118163001663 active site 118163001664 catalytic residue [active] 118163001665 metal binding site [ion binding]; metal-binding site 118163001666 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 118163001667 Cupin domain; Region: Cupin_2; pfam07883 118163001668 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 118163001669 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 118163001670 putative active site [active] 118163001671 putative metal binding site [ion binding]; other site 118163001672 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 118163001673 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 118163001674 active site 118163001675 hydrophilic channel; other site 118163001676 dimerization interface [polypeptide binding]; other site 118163001677 catalytic residues [active] 118163001678 active site lid [active] 118163001679 PUCC protein; Region: PUCC; pfam03209 118163001680 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 118163001681 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 118163001682 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 118163001683 Permease; Region: Permease; cl00510 118163001684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001685 binding surface 118163001686 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163001687 TPR motif; other site 118163001688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163001689 dimerization interface [polypeptide binding]; other site 118163001690 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163001691 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163001692 dimer interface [polypeptide binding]; other site 118163001693 putative CheW interface [polypeptide binding]; other site 118163001694 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 118163001695 Response regulator receiver domain; Region: Response_reg; pfam00072 118163001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001697 active site 118163001698 phosphorylation site [posttranslational modification] 118163001699 intermolecular recognition site; other site 118163001700 dimerization interface [polypeptide binding]; other site 118163001701 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 118163001702 Response regulator receiver domain; Region: Response_reg; pfam00072 118163001703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001704 active site 118163001705 phosphorylation site [posttranslational modification] 118163001706 intermolecular recognition site; other site 118163001707 dimerization interface [polypeptide binding]; other site 118163001708 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 118163001709 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 118163001710 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 118163001711 Ligand Binding Site [chemical binding]; other site 118163001712 cytochrome c biogenesis protein; Region: ccsA; CHL00045 118163001713 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 118163001714 NADPH bind site [chemical binding]; other site 118163001715 putative FMN binding site [chemical binding]; other site 118163001716 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 118163001717 putative FMN binding site [chemical binding]; other site 118163001718 NADPH bind site [chemical binding]; other site 118163001719 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163001720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001721 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163001722 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163001725 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 118163001726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163001727 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163001728 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163001729 DNA binding residues [nucleotide binding] 118163001730 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 118163001731 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 118163001732 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 118163001733 active site 118163001734 substrate binding site [chemical binding]; other site 118163001735 metal binding site [ion binding]; metal-binding site 118163001736 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 118163001737 active site 118163001738 dimerization interface [polypeptide binding]; other site 118163001739 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 118163001740 Nitrogen regulatory protein P-II; Region: P-II; smart00938 118163001741 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 118163001742 active site 118163001743 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 118163001744 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163001745 Walker A/P-loop; other site 118163001746 ATP binding site [chemical binding]; other site 118163001747 Q-loop/lid; other site 118163001748 ABC transporter signature motif; other site 118163001749 Walker B; other site 118163001750 D-loop; other site 118163001751 H-loop/switch region; other site 118163001752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163001753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163001754 active site 118163001755 catalytic tetrad [active] 118163001756 sucrose synthase; Region: sucr_synth; TIGR02470 118163001757 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 118163001758 putative ADP-binding pocket [chemical binding]; other site 118163001759 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 118163001760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 118163001761 RNA binding surface [nucleotide binding]; other site 118163001762 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 118163001763 active site 118163001764 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 118163001765 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 118163001766 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 118163001767 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 118163001768 GIY-YIG motif/motif A; other site 118163001769 active site 118163001770 catalytic site [active] 118163001771 putative DNA binding site [nucleotide binding]; other site 118163001772 metal binding site [ion binding]; metal-binding site 118163001773 UvrB/uvrC motif; Region: UVR; pfam02151 118163001774 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 118163001775 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 118163001776 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 118163001777 Domain of unknown function (DUF814); Region: DUF814; pfam05670 118163001778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163001779 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163001780 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 118163001781 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 118163001782 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 118163001783 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 118163001784 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 118163001785 catalytic site [active] 118163001786 putative active site [active] 118163001787 putative substrate binding site [chemical binding]; other site 118163001788 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163001789 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163001790 active site 118163001791 ATP binding site [chemical binding]; other site 118163001792 substrate binding site [chemical binding]; other site 118163001793 activation loop (A-loop); other site 118163001794 cell division protein DamX; Validated; Region: PRK10905 118163001795 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 118163001796 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 118163001797 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 118163001798 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 118163001799 metal binding site [ion binding]; metal-binding site 118163001800 dimer interface [polypeptide binding]; other site 118163001801 FAD binding domain; Region: FAD_binding_4; pfam01565 118163001802 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 118163001803 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163001804 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 118163001805 putative switch regulator; other site 118163001806 non-specific DNA interactions [nucleotide binding]; other site 118163001807 DNA binding site [nucleotide binding] 118163001808 sequence specific DNA binding site [nucleotide binding]; other site 118163001809 putative cAMP binding site [chemical binding]; other site 118163001810 DALR anticodon binding domain; Region: DALR_1; smart00836 118163001811 anticodon binding site; other site 118163001812 tRNA binding surface [nucleotide binding]; other site 118163001813 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 118163001814 TPR repeat; Region: TPR_11; pfam13414 118163001815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001816 binding surface 118163001817 TPR motif; other site 118163001818 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163001819 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 118163001820 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 118163001821 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 118163001822 active site 118163001823 dimer interface [polypeptide binding]; other site 118163001824 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 118163001825 PHP domain; Region: PHP; pfam02811 118163001826 active site 118163001827 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 118163001828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163001829 motif II; other site 118163001830 GTP-binding protein Der; Reviewed; Region: PRK00093 118163001831 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 118163001832 G1 box; other site 118163001833 GTP/Mg2+ binding site [chemical binding]; other site 118163001834 Switch I region; other site 118163001835 G2 box; other site 118163001836 Switch II region; other site 118163001837 G3 box; other site 118163001838 G4 box; other site 118163001839 G5 box; other site 118163001840 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 118163001841 G1 box; other site 118163001842 GTP/Mg2+ binding site [chemical binding]; other site 118163001843 Switch I region; other site 118163001844 G2 box; other site 118163001845 G3 box; other site 118163001846 Switch II region; other site 118163001847 G4 box; other site 118163001848 G5 box; other site 118163001849 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 118163001850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 118163001851 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 118163001852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 118163001853 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 118163001854 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163001855 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 118163001856 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 118163001857 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 118163001858 active site 118163001859 catalytic site [active] 118163001860 enolase; Provisional; Region: eno; PRK00077 118163001861 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 118163001862 dimer interface [polypeptide binding]; other site 118163001863 metal binding site [ion binding]; metal-binding site 118163001864 substrate binding pocket [chemical binding]; other site 118163001865 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 118163001866 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 118163001867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163001868 binding surface 118163001869 TPR motif; other site 118163001870 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163001871 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163001872 Domain of unknown function DUF39; Region: DUF39; pfam01837 118163001873 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 118163001874 AAA domain; Region: AAA_31; pfam13614 118163001875 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163001876 P-loop; other site 118163001877 Magnesium ion binding site [ion binding]; other site 118163001878 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163001879 Magnesium ion binding site [ion binding]; other site 118163001880 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 118163001881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 118163001882 ABC-ATPase subunit interface; other site 118163001883 dimer interface [polypeptide binding]; other site 118163001884 putative PBP binding regions; other site 118163001885 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 118163001886 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 118163001887 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 118163001888 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 118163001889 intersubunit interface [polypeptide binding]; other site 118163001890 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 118163001891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163001892 GTP-binding protein LepA; Provisional; Region: PRK05433 118163001893 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 118163001894 G1 box; other site 118163001895 putative GEF interaction site [polypeptide binding]; other site 118163001896 GTP/Mg2+ binding site [chemical binding]; other site 118163001897 Switch I region; other site 118163001898 G2 box; other site 118163001899 G3 box; other site 118163001900 Switch II region; other site 118163001901 G4 box; other site 118163001902 G5 box; other site 118163001903 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 118163001904 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 118163001905 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 118163001906 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163001907 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163001908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163001909 dimer interface [polypeptide binding]; other site 118163001910 phosphorylation site [posttranslational modification] 118163001911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163001912 ATP binding site [chemical binding]; other site 118163001913 Mg2+ binding site [ion binding]; other site 118163001914 G-X-G motif; other site 118163001915 NifU-like domain; Region: NifU; pfam01106 118163001916 Ion transport protein; Region: Ion_trans; pfam00520 118163001917 Ion channel; Region: Ion_trans_2; pfam07885 118163001918 Double zinc ribbon; Region: DZR; pfam12773 118163001919 arogenate dehydrogenase; Reviewed; Region: PRK07417 118163001920 prephenate dehydrogenase; Validated; Region: PRK08507 118163001921 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 118163001922 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163001923 putative binding surface; other site 118163001924 active site 118163001925 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 118163001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163001927 motif II; other site 118163001928 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 118163001929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163001930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163001931 GUN4-like; Region: GUN4; pfam05419 118163001932 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163001933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163001934 S-adenosylmethionine binding site [chemical binding]; other site 118163001935 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 118163001936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163001937 FeS/SAM binding site; other site 118163001938 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 118163001939 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163001940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001941 active site 118163001942 phosphorylation site [posttranslational modification] 118163001943 intermolecular recognition site; other site 118163001944 dimerization interface [polypeptide binding]; other site 118163001945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163001946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163001947 dimer interface [polypeptide binding]; other site 118163001948 phosphorylation site [posttranslational modification] 118163001949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163001950 ATP binding site [chemical binding]; other site 118163001951 Mg2+ binding site [ion binding]; other site 118163001952 G-X-G motif; other site 118163001953 Response regulator receiver domain; Region: Response_reg; pfam00072 118163001954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001955 active site 118163001956 phosphorylation site [posttranslational modification] 118163001957 intermolecular recognition site; other site 118163001958 dimerization interface [polypeptide binding]; other site 118163001959 Response regulator receiver domain; Region: Response_reg; pfam00072 118163001960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163001961 active site 118163001962 phosphorylation site [posttranslational modification] 118163001963 intermolecular recognition site; other site 118163001964 dimerization interface [polypeptide binding]; other site 118163001965 PAS domain S-box; Region: sensory_box; TIGR00229 118163001966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163001967 putative active site [active] 118163001968 heme pocket [chemical binding]; other site 118163001969 PAS domain S-box; Region: sensory_box; TIGR00229 118163001970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163001971 putative active site [active] 118163001972 heme pocket [chemical binding]; other site 118163001973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163001974 dimer interface [polypeptide binding]; other site 118163001975 phosphorylation site [posttranslational modification] 118163001976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163001977 ATP binding site [chemical binding]; other site 118163001978 Mg2+ binding site [ion binding]; other site 118163001979 G-X-G motif; other site 118163001980 multifunctional aminopeptidase A; Provisional; Region: PRK00913 118163001981 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 118163001982 interface (dimer of trimers) [polypeptide binding]; other site 118163001983 Substrate-binding/catalytic site; other site 118163001984 Zn-binding sites [ion binding]; other site 118163001985 Peptidase family M48; Region: Peptidase_M48; pfam01435 118163001986 glutathione reductase; Validated; Region: PRK06116 118163001987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163001988 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 118163001989 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 118163001990 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 118163001991 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 118163001992 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 118163001993 intersubunit interface [polypeptide binding]; other site 118163001994 active site 118163001995 catalytic residue [active] 118163001996 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 118163001997 Recombination protein O N terminal; Region: RecO_N; pfam11967 118163001998 Recombination protein O C terminal; Region: RecO_C; pfam02565 118163001999 H+ Antiporter protein; Region: 2A0121; TIGR00900 118163002000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163002001 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163002002 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 118163002003 substrate binding pocket [chemical binding]; other site 118163002004 substrate-Mg2+ binding site; other site 118163002005 aspartate-rich region 1; other site 118163002006 aspartate-rich region 2; other site 118163002007 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 118163002008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163002009 Walker A/P-loop; other site 118163002010 ATP binding site [chemical binding]; other site 118163002011 Q-loop/lid; other site 118163002012 ABC transporter signature motif; other site 118163002013 Walker B; other site 118163002014 D-loop; other site 118163002015 H-loop/switch region; other site 118163002016 TOBE domain; Region: TOBE_2; pfam08402 118163002017 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 118163002018 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 118163002019 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 118163002020 active site 118163002021 catalytic residues [active] 118163002022 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 118163002023 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 118163002024 dimer interface [polypeptide binding]; other site 118163002025 putative anticodon binding site; other site 118163002026 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 118163002027 motif 1; other site 118163002028 active site 118163002029 motif 2; other site 118163002030 motif 3; other site 118163002031 KTSC domain; Region: KTSC; pfam13619 118163002032 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 118163002033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163002034 Coenzyme A binding pocket [chemical binding]; other site 118163002035 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163002036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163002037 S-adenosylmethionine binding site [chemical binding]; other site 118163002038 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163002039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163002040 S-adenosylmethionine binding site [chemical binding]; other site 118163002041 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 118163002042 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 118163002043 dimer interface [polypeptide binding]; other site 118163002044 motif 1; other site 118163002045 active site 118163002046 motif 2; other site 118163002047 motif 3; other site 118163002048 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 118163002049 anticodon binding site; other site 118163002050 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 118163002051 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 118163002052 dimer interface [polypeptide binding]; other site 118163002053 substrate binding site [chemical binding]; other site 118163002054 ATP binding site [chemical binding]; other site 118163002055 cell division protein FtsZ; Region: ftsZ; TIGR00065 118163002056 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 118163002057 nucleotide binding site [chemical binding]; other site 118163002058 SulA interaction site; other site 118163002059 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 118163002060 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 118163002061 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 118163002062 C-terminal peptidase (prc); Region: prc; TIGR00225 118163002063 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 118163002064 protein binding site [polypeptide binding]; other site 118163002065 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 118163002066 Catalytic dyad [active] 118163002067 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 118163002068 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 118163002069 Walker A/P-loop; other site 118163002070 ATP binding site [chemical binding]; other site 118163002071 Q-loop/lid; other site 118163002072 ABC transporter signature motif; other site 118163002073 Walker B; other site 118163002074 D-loop; other site 118163002075 H-loop/switch region; other site 118163002076 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 118163002077 Response regulator receiver domain; Region: Response_reg; pfam00072 118163002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002079 active site 118163002080 phosphorylation site [posttranslational modification] 118163002081 intermolecular recognition site; other site 118163002082 dimerization interface [polypeptide binding]; other site 118163002083 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 118163002084 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 118163002085 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 118163002086 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 118163002087 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 118163002088 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163002089 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 118163002090 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163002091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163002092 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 118163002093 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163002094 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163002095 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163002096 Phosphotransferase enzyme family; Region: APH; pfam01636 118163002097 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 118163002098 active site 118163002099 ATP binding site [chemical binding]; other site 118163002100 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 118163002101 substrate binding site [chemical binding]; other site 118163002102 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 118163002103 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 118163002104 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 118163002105 purine monophosphate binding site [chemical binding]; other site 118163002106 dimer interface [polypeptide binding]; other site 118163002107 putative catalytic residues [active] 118163002108 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 118163002109 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 118163002110 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 118163002111 Repair protein; Region: Repair_PSII; pfam04536 118163002112 precorrin-8X methylmutase; Validated; Region: PRK05953 118163002113 Precorrin-8X methylmutase; Region: CbiC; pfam02570 118163002114 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 118163002115 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163002116 catalytic triad [active] 118163002117 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 118163002118 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 118163002119 hinge; other site 118163002120 active site 118163002121 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163002122 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163002123 phosphopeptide binding site; other site 118163002124 PAS domain S-box; Region: sensory_box; TIGR00229 118163002125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163002126 putative active site [active] 118163002127 heme pocket [chemical binding]; other site 118163002128 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002129 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163002131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163002132 metal binding site [ion binding]; metal-binding site 118163002133 active site 118163002134 I-site; other site 118163002135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163002136 DNA polymerase I; Provisional; Region: PRK05755 118163002137 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 118163002138 active site 118163002139 metal binding site 1 [ion binding]; metal-binding site 118163002140 putative 5' ssDNA interaction site; other site 118163002141 metal binding site 3; metal-binding site 118163002142 metal binding site 2 [ion binding]; metal-binding site 118163002143 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 118163002144 putative DNA binding site [nucleotide binding]; other site 118163002145 putative metal binding site [ion binding]; other site 118163002146 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 118163002147 active site 118163002148 catalytic site [active] 118163002149 substrate binding site [chemical binding]; other site 118163002150 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 118163002151 active site 118163002152 DNA binding site [nucleotide binding] 118163002153 catalytic site [active] 118163002154 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 118163002155 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 118163002156 GUN4-like; Region: GUN4; pfam05419 118163002157 Uncharacterized conserved protein [Function unknown]; Region: COG2912 118163002158 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 118163002159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163002160 binding surface 118163002161 TPR motif; other site 118163002162 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 118163002163 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 118163002164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 118163002165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 118163002166 Protein of unknown function (DUF1670); Region: DUF1670; pfam07900 118163002167 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 118163002168 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 118163002169 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163002170 dimer interface [polypeptide binding]; other site 118163002171 [2Fe-2S] cluster binding site [ion binding]; other site 118163002172 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 118163002173 SLBB domain; Region: SLBB; pfam10531 118163002174 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 118163002175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163002176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163002177 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 118163002178 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 118163002179 SnoaL-like domain; Region: SnoaL_3; pfam13474 118163002180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163002181 active site 118163002182 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163002183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163002184 active site 118163002185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163002186 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 118163002187 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 118163002188 NADP-binding site; other site 118163002189 homotetramer interface [polypeptide binding]; other site 118163002190 substrate binding site [chemical binding]; other site 118163002191 homodimer interface [polypeptide binding]; other site 118163002192 active site 118163002193 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163002194 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 118163002195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 118163002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163002197 dimer interface [polypeptide binding]; other site 118163002198 conserved gate region; other site 118163002199 putative PBP binding loops; other site 118163002200 ABC-ATPase subunit interface; other site 118163002201 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 118163002202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163002203 dimer interface [polypeptide binding]; other site 118163002204 conserved gate region; other site 118163002205 putative PBP binding loops; other site 118163002206 ABC-ATPase subunit interface; other site 118163002207 recombinase A; Provisional; Region: recA; PRK09354 118163002208 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 118163002209 hexamer interface [polypeptide binding]; other site 118163002210 Walker A motif; other site 118163002211 ATP binding site [chemical binding]; other site 118163002212 Walker B motif; other site 118163002213 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163002214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163002215 structural tetrad; other site 118163002216 Tic20-like protein; Region: Tic20; pfam09685 118163002217 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 118163002218 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 118163002219 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 118163002220 dimer interface [polypeptide binding]; other site 118163002221 motif 1; other site 118163002222 active site 118163002223 motif 2; other site 118163002224 motif 3; other site 118163002225 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 118163002226 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 118163002227 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 118163002228 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 118163002229 Peptidase family M23; Region: Peptidase_M23; pfam01551 118163002230 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 118163002231 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 118163002232 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 118163002233 dimer interface [polypeptide binding]; other site 118163002234 decamer (pentamer of dimers) interface [polypeptide binding]; other site 118163002235 catalytic triad [active] 118163002236 peroxidatic and resolving cysteines [active] 118163002237 PemK-like protein; Region: PemK; pfam02452 118163002238 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 118163002239 putative ADP-ribose binding site [chemical binding]; other site 118163002240 putative active site [active] 118163002241 EVE domain; Region: EVE; pfam01878 118163002242 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 118163002243 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 118163002244 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 118163002245 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 118163002246 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 118163002247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163002248 catalytic residue [active] 118163002249 Domain of unknown function DUF29; Region: DUF29; pfam01724 118163002250 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 118163002251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163002252 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 118163002253 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 118163002254 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 118163002255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163002256 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 118163002257 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 118163002258 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 118163002259 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 118163002260 substrate binding pocket [chemical binding]; other site 118163002261 chain length determination region; other site 118163002262 substrate-Mg2+ binding site; other site 118163002263 catalytic residues [active] 118163002264 aspartate-rich region 1; other site 118163002265 active site lid residues [active] 118163002266 aspartate-rich region 2; other site 118163002267 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 118163002268 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163002269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002270 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002271 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002272 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002273 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002274 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 118163002275 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163002276 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163002277 phosphopeptide binding site; other site 118163002278 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 118163002279 Transglycosylase; Region: Transgly; pfam00912 118163002280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 118163002281 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 118163002282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163002283 NAD(P) binding site [chemical binding]; other site 118163002284 active site 118163002285 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 118163002286 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163002287 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163002288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 118163002289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 118163002290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 118163002291 dimerization interface [polypeptide binding]; other site 118163002292 hypothetical protein; Provisional; Region: PRK07394 118163002293 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 118163002294 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 118163002295 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 118163002296 dimer interface [polypeptide binding]; other site 118163002297 ADP-ribose binding site [chemical binding]; other site 118163002298 active site 118163002299 nudix motif; other site 118163002300 metal binding site [ion binding]; metal-binding site 118163002301 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 118163002302 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 118163002303 active site 118163002304 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 118163002305 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 118163002306 Cytochrome c; Region: Cytochrom_C; cl11414 118163002307 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 118163002308 active site 118163002309 FMN binding site [chemical binding]; other site 118163002310 substrate binding site [chemical binding]; other site 118163002311 putative catalytic residue [active] 118163002312 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 118163002313 phosphate binding site [ion binding]; other site 118163002314 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 118163002315 classical (c) SDRs; Region: SDR_c; cd05233 118163002316 NAD(P) binding site [chemical binding]; other site 118163002317 active site 118163002318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163002319 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163002320 active site 118163002321 ATP binding site [chemical binding]; other site 118163002322 substrate binding site [chemical binding]; other site 118163002323 activation loop (A-loop); other site 118163002324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163002325 TPR repeat; Region: TPR_11; pfam13414 118163002326 binding surface 118163002327 TPR motif; other site 118163002328 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163002329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163002330 catalytic loop [active] 118163002331 iron binding site [ion binding]; other site 118163002332 Phycobilisome protein; Region: Phycobilisome; cl08227 118163002333 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163002334 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163002335 catalytic loop [active] 118163002336 iron binding site [ion binding]; other site 118163002337 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 118163002338 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 118163002339 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 118163002340 V4R domain; Region: V4R; pfam02830 118163002341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163002342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163002343 WHG domain; Region: WHG; pfam13305 118163002344 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 118163002345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163002346 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 118163002347 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 118163002348 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 118163002349 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 118163002350 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 118163002351 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 118163002352 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 118163002353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163002354 Walker A motif; other site 118163002355 ATP binding site [chemical binding]; other site 118163002356 Walker B motif; other site 118163002357 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163002358 TrkA-N domain; Region: TrkA_N; pfam02254 118163002359 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 118163002360 TrkA-N domain; Region: TrkA_N; pfam02254 118163002361 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 118163002362 DHH family; Region: DHH; pfam01368 118163002363 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 118163002364 FOG: CBS domain [General function prediction only]; Region: COG0517 118163002365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 118163002366 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 118163002367 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 118163002368 active site 118163002369 NTP binding site [chemical binding]; other site 118163002370 metal binding triad [ion binding]; metal-binding site 118163002371 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 118163002372 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 118163002373 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 118163002374 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 118163002375 homopentamer interface [polypeptide binding]; other site 118163002376 active site 118163002377 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 118163002378 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163002379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163002380 ligand binding site [chemical binding]; other site 118163002381 flexible hinge region; other site 118163002382 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 118163002383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163002384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163002385 ligand binding site [chemical binding]; other site 118163002386 flexible hinge region; other site 118163002387 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 118163002388 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 118163002389 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 118163002390 putative catalytic cysteine [active] 118163002391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002393 active site 118163002394 phosphorylation site [posttranslational modification] 118163002395 intermolecular recognition site; other site 118163002396 dimerization interface [polypeptide binding]; other site 118163002397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163002398 DNA binding site [nucleotide binding] 118163002399 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 118163002400 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 118163002401 putative NAD(P) binding site [chemical binding]; other site 118163002402 putative substrate binding site [chemical binding]; other site 118163002403 catalytic Zn binding site [ion binding]; other site 118163002404 structural Zn binding site [ion binding]; other site 118163002405 dimer interface [polypeptide binding]; other site 118163002406 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 118163002407 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 118163002408 FMN binding site [chemical binding]; other site 118163002409 active site 118163002410 catalytic residues [active] 118163002411 substrate binding site [chemical binding]; other site 118163002412 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 118163002413 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 118163002414 membrane protein; Provisional; Region: PRK14419 118163002415 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 118163002416 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 118163002417 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 118163002418 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 118163002419 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163002420 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 118163002421 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 118163002422 ligand binding site [chemical binding]; other site 118163002423 NAD binding site [chemical binding]; other site 118163002424 dimerization interface [polypeptide binding]; other site 118163002425 catalytic site [active] 118163002426 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 118163002427 putative L-serine binding site [chemical binding]; other site 118163002428 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 118163002429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163002430 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 118163002431 active site 118163002432 homodimer interface [polypeptide binding]; other site 118163002433 SAM binding site [chemical binding]; other site 118163002434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163002435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163002436 Walker A/P-loop; other site 118163002437 ATP binding site [chemical binding]; other site 118163002438 Q-loop/lid; other site 118163002439 ABC transporter signature motif; other site 118163002440 Walker B; other site 118163002441 D-loop; other site 118163002442 H-loop/switch region; other site 118163002443 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 118163002444 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 118163002445 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 118163002446 intersubunit interface [polypeptide binding]; other site 118163002447 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 118163002448 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 118163002449 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 118163002450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 118163002451 ABC-ATPase subunit interface; other site 118163002452 dimer interface [polypeptide binding]; other site 118163002453 putative PBP binding regions; other site 118163002454 PemK-like protein; Region: PemK; pfam02452 118163002455 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 118163002456 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 118163002457 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 118163002458 Yqey-like protein; Region: YqeY; pfam09424 118163002459 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 118163002460 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 118163002461 G1 box; other site 118163002462 GTP/Mg2+ binding site [chemical binding]; other site 118163002463 Switch I region; other site 118163002464 G2 box; other site 118163002465 Switch II region; other site 118163002466 G3 box; other site 118163002467 G4 box; other site 118163002468 G5 box; other site 118163002469 Domain of unknown function (DUF697); Region: DUF697; pfam05128 118163002470 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 118163002471 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 118163002472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163002473 dimer interface [polypeptide binding]; other site 118163002474 conserved gate region; other site 118163002475 putative PBP binding loops; other site 118163002476 ABC-ATPase subunit interface; other site 118163002477 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 118163002478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163002479 dimer interface [polypeptide binding]; other site 118163002480 conserved gate region; other site 118163002481 putative PBP binding loops; other site 118163002482 ABC-ATPase subunit interface; other site 118163002483 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 118163002484 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 118163002485 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 118163002486 4Fe-4S binding domain; Region: Fer4; pfam00037 118163002487 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 118163002488 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 118163002489 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 118163002490 photosystem II reaction center protein J; Provisional; Region: PRK02565 118163002491 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 118163002492 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 118163002493 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 118163002494 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 118163002495 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 118163002496 Ycf48-like protein; Provisional; Region: PRK13684 118163002497 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 118163002498 Rubredoxin; Region: Rubredoxin; pfam00301 118163002499 iron binding site [ion binding]; other site 118163002500 circadian clock protein KaiC; Reviewed; Region: PRK09302 118163002501 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 118163002502 Walker A motif; other site 118163002503 ATP binding site [chemical binding]; other site 118163002504 Walker B motif; other site 118163002505 recA bacterial DNA recombination protein; Region: RecA; cl17211 118163002506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 118163002507 Walker A motif; other site 118163002508 ATP binding site [chemical binding]; other site 118163002509 Walker B motif; other site 118163002510 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 118163002511 tetramer interface [polypeptide binding]; other site 118163002512 dimer interface [polypeptide binding]; other site 118163002513 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163002514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002515 active site 118163002516 phosphorylation site [posttranslational modification] 118163002517 intermolecular recognition site; other site 118163002518 dimerization interface [polypeptide binding]; other site 118163002519 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 118163002520 metal-binding site [ion binding] 118163002521 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 118163002522 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 118163002523 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163002524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163002525 motif II; other site 118163002526 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163002527 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163002528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163002529 phosphopeptide binding site; other site 118163002530 DNA polymerase III subunit delta'; Validated; Region: PRK07399 118163002531 DNA polymerase III subunit delta'; Validated; Region: PRK08485 118163002532 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163002533 Protein of unknown function, DUF393; Region: DUF393; pfam04134 118163002534 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 118163002535 Response regulator receiver domain; Region: Response_reg; pfam00072 118163002536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002537 active site 118163002538 phosphorylation site [posttranslational modification] 118163002539 intermolecular recognition site; other site 118163002540 dimerization interface [polypeptide binding]; other site 118163002541 Response regulator receiver domain; Region: Response_reg; pfam00072 118163002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002543 active site 118163002544 phosphorylation site [posttranslational modification] 118163002545 intermolecular recognition site; other site 118163002546 dimerization interface [polypeptide binding]; other site 118163002547 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 118163002548 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002549 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002550 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002551 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002552 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002553 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002555 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002556 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002557 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002558 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163002559 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163002560 dimer interface [polypeptide binding]; other site 118163002561 putative CheW interface [polypeptide binding]; other site 118163002562 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 118163002563 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163002564 putative binding surface; other site 118163002565 active site 118163002566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163002567 ATP binding site [chemical binding]; other site 118163002568 Mg2+ binding site [ion binding]; other site 118163002569 G-X-G motif; other site 118163002570 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 118163002571 Response regulator receiver domain; Region: Response_reg; pfam00072 118163002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002573 active site 118163002574 phosphorylation site [posttranslational modification] 118163002575 intermolecular recognition site; other site 118163002576 dimerization interface [polypeptide binding]; other site 118163002577 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 118163002578 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 118163002579 FMN binding site [chemical binding]; other site 118163002580 active site 118163002581 catalytic residues [active] 118163002582 substrate binding site [chemical binding]; other site 118163002583 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 118163002584 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163002585 DRTGG domain; Region: DRTGG; pfam07085 118163002586 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 118163002587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 118163002588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 118163002589 Response regulator receiver domain; Region: Response_reg; pfam00072 118163002590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002591 active site 118163002592 phosphorylation site [posttranslational modification] 118163002593 intermolecular recognition site; other site 118163002594 dimerization interface [polypeptide binding]; other site 118163002595 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 118163002596 GAF domain; Region: GAF; pfam01590 118163002597 Phytochrome region; Region: PHY; pfam00360 118163002598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163002599 dimer interface [polypeptide binding]; other site 118163002600 phosphorylation site [posttranslational modification] 118163002601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163002602 ATP binding site [chemical binding]; other site 118163002603 Mg2+ binding site [ion binding]; other site 118163002604 G-X-G motif; other site 118163002605 FtsH Extracellular; Region: FtsH_ext; pfam06480 118163002606 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 118163002607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163002608 Walker A motif; other site 118163002609 ATP binding site [chemical binding]; other site 118163002610 Walker B motif; other site 118163002611 arginine finger; other site 118163002612 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163002613 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 118163002614 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 118163002615 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 118163002616 NAD(P) binding site [chemical binding]; other site 118163002617 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 118163002618 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163002619 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163002620 DevC protein; Region: devC; TIGR01185 118163002621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163002622 FtsX-like permease family; Region: FtsX; pfam02687 118163002623 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 118163002624 four helix bundle protein; Region: TIGR02436 118163002625 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 118163002626 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163002627 Walker A/P-loop; other site 118163002628 ATP binding site [chemical binding]; other site 118163002629 Q-loop/lid; other site 118163002630 ABC transporter signature motif; other site 118163002631 Walker B; other site 118163002632 D-loop; other site 118163002633 H-loop/switch region; other site 118163002634 Peptidase family M48; Region: Peptidase_M48; pfam01435 118163002635 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163002636 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163002637 Protein of unknown function; Region: DUF3971; pfam13116 118163002638 Family of unknown function (DUF490); Region: DUF490; pfam04357 118163002639 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163002640 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163002641 protein binding site [polypeptide binding]; other site 118163002642 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 118163002643 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 118163002644 Fatty acid desaturase; Region: FA_desaturase; pfam00487 118163002645 putative di-iron ligands [ion binding]; other site 118163002646 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 118163002647 NurA domain; Region: NurA; pfam09376 118163002648 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 118163002649 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 118163002650 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163002651 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 118163002652 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163002653 NACHT domain; Region: NACHT; pfam05729 118163002654 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 118163002655 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 118163002656 HEAT repeats; Region: HEAT_2; pfam13646 118163002657 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 118163002658 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002659 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002660 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163002661 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163002662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163002663 PAS domain; Region: PAS_9; pfam13426 118163002664 putative active site [active] 118163002665 heme pocket [chemical binding]; other site 118163002666 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163002667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163002668 dimer interface [polypeptide binding]; other site 118163002669 putative CheW interface [polypeptide binding]; other site 118163002670 CheW-like domain; Region: CheW; pfam01584 118163002671 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163002672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002673 active site 118163002674 phosphorylation site [posttranslational modification] 118163002675 intermolecular recognition site; other site 118163002676 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 118163002677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163002678 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 118163002679 active site 118163002680 catalytic triad [active] 118163002681 oxyanion hole [active] 118163002682 cytosine deaminase-like protein; Validated; Region: PRK07583 118163002683 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 118163002684 active site 118163002685 Predicted membrane protein [Function unknown]; Region: COG1950 118163002686 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002687 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002688 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163002689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163002691 PemK-like protein; Region: PemK; pfam02452 118163002692 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 118163002693 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 118163002694 FAD binding domain; Region: FAD_binding_4; pfam01565 118163002695 Uncharacterized conserved protein [Function unknown]; Region: COG0398 118163002696 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 118163002697 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 118163002698 Creatinine amidohydrolase; Region: Creatininase; pfam02633 118163002699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 118163002700 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 118163002701 Walker A/P-loop; other site 118163002702 ATP binding site [chemical binding]; other site 118163002703 Q-loop/lid; other site 118163002704 ABC transporter signature motif; other site 118163002705 Walker B; other site 118163002706 D-loop; other site 118163002707 H-loop/switch region; other site 118163002708 Ferredoxin [Energy production and conversion]; Region: COG1146 118163002709 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 118163002710 Protein of unknown function (DUF565); Region: DUF565; pfam04483 118163002711 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 118163002712 active site 118163002713 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 118163002714 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 118163002715 molybdopterin cofactor binding site; other site 118163002716 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 118163002717 molybdopterin cofactor binding site; other site 118163002718 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 118163002719 iron-sulfur cluster [ion binding]; other site 118163002720 [2Fe-2S] cluster binding site [ion binding]; other site 118163002721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163002722 putative active site [active] 118163002723 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 118163002724 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 118163002725 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 118163002726 active site 118163002727 homodimer interface [polypeptide binding]; other site 118163002728 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163002729 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 118163002730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163002731 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163002732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163002733 motif II; other site 118163002734 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163002735 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 118163002736 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 118163002737 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 118163002738 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 118163002739 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 118163002740 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 118163002741 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 118163002742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163002743 Walker A motif; other site 118163002744 ATP binding site [chemical binding]; other site 118163002745 Walker B motif; other site 118163002746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 118163002747 Clp protease; Region: CLP_protease; pfam00574 118163002748 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 118163002749 oligomer interface [polypeptide binding]; other site 118163002750 active site residues [active] 118163002751 trigger factor; Provisional; Region: tig; PRK01490 118163002752 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 118163002753 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 118163002754 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 118163002755 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 118163002756 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 118163002757 dihydrodipicolinate synthase; Region: dapA; TIGR00674 118163002758 dimer interface [polypeptide binding]; other site 118163002759 active site 118163002760 catalytic residue [active] 118163002761 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 118163002762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 118163002763 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 118163002764 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 118163002765 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 118163002766 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 118163002767 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 118163002768 Moco binding site; other site 118163002769 metal coordination site [ion binding]; other site 118163002770 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 118163002771 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 118163002772 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 118163002773 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 118163002774 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 118163002775 Active Sites [active] 118163002776 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 118163002777 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 118163002778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163002779 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 118163002780 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 118163002781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 118163002782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163002783 putative substrate translocation pore; other site 118163002784 SET domain; Region: SET; cl02566 118163002785 SET domain; Region: SET; pfam00856 118163002786 SET domain; Region: SET; pfam00856 118163002787 SET domain; Region: SET; pfam00856 118163002788 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 118163002789 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 118163002790 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 118163002791 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163002792 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 118163002793 NAD binding site [chemical binding]; other site 118163002794 putative substrate binding site 2 [chemical binding]; other site 118163002795 putative substrate binding site 1 [chemical binding]; other site 118163002796 active site 118163002797 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 118163002798 RNA/DNA hybrid binding site [nucleotide binding]; other site 118163002799 active site 118163002800 Uncharacterized conserved protein [Function unknown]; Region: COG0432 118163002801 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 118163002802 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 118163002803 [2Fe-2S] cluster binding site [ion binding]; other site 118163002804 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 118163002805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163002806 ATP binding site [chemical binding]; other site 118163002807 putative Mg++ binding site [ion binding]; other site 118163002808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163002809 nucleotide binding region [chemical binding]; other site 118163002810 ATP-binding site [chemical binding]; other site 118163002811 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 118163002812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163002813 dimer interface [polypeptide binding]; other site 118163002814 conserved gate region; other site 118163002815 putative PBP binding loops; other site 118163002816 ABC-ATPase subunit interface; other site 118163002817 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 118163002818 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 118163002819 ATP binding site [chemical binding]; other site 118163002820 active site 118163002821 substrate binding site [chemical binding]; other site 118163002822 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 118163002823 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 118163002824 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 118163002825 Surface antigen; Region: Bac_surface_Ag; pfam01103 118163002826 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 118163002827 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 118163002828 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 118163002829 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 118163002830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163002831 motif II; other site 118163002832 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 118163002833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163002834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163002835 active site 118163002836 phosphorylation site [posttranslational modification] 118163002837 intermolecular recognition site; other site 118163002838 dimerization interface [polypeptide binding]; other site 118163002839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163002840 DNA binding site [nucleotide binding] 118163002841 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 118163002842 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 118163002843 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 118163002844 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 118163002845 Ycf46; Provisional; Region: ycf46; CHL00195 118163002846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163002847 Walker A motif; other site 118163002848 ATP binding site [chemical binding]; other site 118163002849 Walker B motif; other site 118163002850 arginine finger; other site 118163002851 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 118163002852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163002853 Probable transposase; Region: OrfB_IS605; pfam01385 118163002854 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163002855 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 118163002856 DXD motif; other site 118163002857 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 118163002858 CpeS-like protein; Region: CpeS; pfam09367 118163002859 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 118163002860 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 118163002861 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 118163002862 Walker A/P-loop; other site 118163002863 ATP binding site [chemical binding]; other site 118163002864 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 118163002865 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 118163002866 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 118163002867 ABC transporter signature motif; other site 118163002868 Walker B; other site 118163002869 D-loop; other site 118163002870 H-loop/switch region; other site 118163002871 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 118163002872 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 118163002873 ring oligomerisation interface [polypeptide binding]; other site 118163002874 ATP/Mg binding site [chemical binding]; other site 118163002875 stacking interactions; other site 118163002876 hinge regions; other site 118163002877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 118163002878 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 118163002879 NAD(P) binding site [chemical binding]; other site 118163002880 homotetramer interface [polypeptide binding]; other site 118163002881 homodimer interface [polypeptide binding]; other site 118163002882 active site 118163002883 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 118163002884 Uncharacterized conserved protein [Function unknown]; Region: COG3937 118163002885 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 118163002886 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 118163002887 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 118163002888 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 118163002889 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 118163002890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163002891 Walker A motif; other site 118163002892 ATP binding site [chemical binding]; other site 118163002893 Walker B motif; other site 118163002894 arginine finger; other site 118163002895 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 118163002896 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 118163002897 heterotetramer interface [polypeptide binding]; other site 118163002898 active site pocket [active] 118163002899 cleavage site 118163002900 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 118163002901 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163002902 Walker A/P-loop; other site 118163002903 ATP binding site [chemical binding]; other site 118163002904 Q-loop/lid; other site 118163002905 ABC transporter signature motif; other site 118163002906 Walker B; other site 118163002907 D-loop; other site 118163002908 H-loop/switch region; other site 118163002909 DevC protein; Region: devC; TIGR01185 118163002910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163002911 FtsX-like permease family; Region: FtsX; pfam02687 118163002912 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 118163002913 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163002914 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163002915 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 118163002916 FAD binding domain; Region: FAD_binding_4; pfam01565 118163002917 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 118163002918 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 118163002919 DNA photolyase; Region: DNA_photolyase; pfam00875 118163002920 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 118163002921 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 118163002922 dimer interface [polypeptide binding]; other site 118163002923 ADP-ribose binding site [chemical binding]; other site 118163002924 active site 118163002925 nudix motif; other site 118163002926 metal binding site [ion binding]; metal-binding site 118163002927 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 118163002928 catalytic center binding site [active] 118163002929 ATP binding site [chemical binding]; other site 118163002930 short chain dehydrogenase; Provisional; Region: PRK06181 118163002931 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 118163002932 putative NAD(P) binding site [chemical binding]; other site 118163002933 homotetramer interface [polypeptide binding]; other site 118163002934 active site 118163002935 homodimer interface [polypeptide binding]; other site 118163002936 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 118163002937 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 118163002938 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163002939 NAD binding site [chemical binding]; other site 118163002940 substrate binding site [chemical binding]; other site 118163002941 active site 118163002942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163002943 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 118163002944 ribosomal protein L19; Region: rpl19; CHL00084 118163002945 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 118163002946 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 118163002947 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 118163002948 putative homodimer interface [polypeptide binding]; other site 118163002949 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 118163002950 heterodimer interface [polypeptide binding]; other site 118163002951 homodimer interface [polypeptide binding]; other site 118163002952 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 118163002953 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 118163002954 23S rRNA interface [nucleotide binding]; other site 118163002955 L7/L12 interface [polypeptide binding]; other site 118163002956 putative thiostrepton binding site; other site 118163002957 L25 interface [polypeptide binding]; other site 118163002958 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 118163002959 mRNA/rRNA interface [nucleotide binding]; other site 118163002960 Ribosomal protein L10 leader; IMG reference gene:2509572984; Ple7327_1101 118163002961 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 118163002962 23S rRNA interface [nucleotide binding]; other site 118163002963 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 118163002964 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 118163002965 peripheral dimer interface [polypeptide binding]; other site 118163002966 core dimer interface [polypeptide binding]; other site 118163002967 L10 interface [polypeptide binding]; other site 118163002968 L11 interface [polypeptide binding]; other site 118163002969 putative EF-Tu interaction site [polypeptide binding]; other site 118163002970 putative EF-G interaction site [polypeptide binding]; other site 118163002971 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 118163002972 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 118163002973 active site 118163002974 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 118163002975 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 118163002976 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 118163002977 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163002978 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163002979 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 118163002980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163002981 nucleophilic elbow; other site 118163002982 catalytic triad; other site 118163002983 ABC-2 type transporter; Region: ABC2_membrane; cl17235 118163002984 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 118163002985 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 118163002986 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 118163002987 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 118163002988 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 118163002989 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 118163002990 ligand binding site [chemical binding]; other site 118163002991 homodimer interface [polypeptide binding]; other site 118163002992 NAD(P) binding site [chemical binding]; other site 118163002993 trimer interface B [polypeptide binding]; other site 118163002994 trimer interface A [polypeptide binding]; other site 118163002995 Late competence development protein ComFB; Region: ComFB; pfam10719 118163002996 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 118163002997 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 118163002998 putative active site [active] 118163002999 Zn binding site [ion binding]; other site 118163003000 DevC protein; Region: devC; TIGR01185 118163003001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163003002 FtsX-like permease family; Region: FtsX; pfam02687 118163003003 precorrin-8X methylmutase; Provisional; Region: PRK05954 118163003004 Precorrin-8X methylmutase; Region: CbiC; pfam02570 118163003005 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 118163003006 active site 118163003007 putative homodimer interface [polypeptide binding]; other site 118163003008 SAM binding site [chemical binding]; other site 118163003009 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 118163003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003011 S-adenosylmethionine binding site [chemical binding]; other site 118163003012 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 118163003013 TAP-like protein; Region: Abhydrolase_4; pfam08386 118163003014 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 118163003015 Uncharacterized conserved protein [Function unknown]; Region: COG1434 118163003016 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 118163003017 putative active site [active] 118163003018 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163003019 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163003020 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163003021 protein binding site [polypeptide binding]; other site 118163003022 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 118163003023 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 118163003024 NADP binding site [chemical binding]; other site 118163003025 active site 118163003026 putative substrate binding site [chemical binding]; other site 118163003027 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 118163003028 pheophytin binding site; other site 118163003029 chlorophyll binding site; other site 118163003030 quinone binding site; other site 118163003031 Fe binding site [ion binding]; other site 118163003032 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 118163003033 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163003034 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163003035 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 118163003036 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 118163003037 active site 118163003038 catalytic residues [active] 118163003039 metal binding site [ion binding]; metal-binding site 118163003040 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 118163003041 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163003042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163003043 catalytic loop [active] 118163003044 iron binding site [ion binding]; other site 118163003045 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 118163003046 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 118163003047 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 118163003048 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 118163003049 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 118163003050 active site 118163003051 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 118163003052 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 118163003053 active site 118163003054 catalytic residues [active] 118163003055 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 118163003056 MltA specific insert domain; Region: MltA; pfam03562 118163003057 3D domain; Region: 3D; pfam06725 118163003058 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163003059 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 118163003060 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 118163003061 active site 118163003062 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 118163003063 MoaE interaction surface [polypeptide binding]; other site 118163003064 MoeB interaction surface [polypeptide binding]; other site 118163003065 thiocarboxylated glycine; other site 118163003066 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 118163003067 dimer interface [polypeptide binding]; other site 118163003068 motif 1; other site 118163003069 active site 118163003070 motif 2; other site 118163003071 motif 3; other site 118163003072 DDE superfamily endonuclease; Region: DDE_3; pfam13358 118163003073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 118163003074 NAD synthetase; Provisional; Region: PRK13981 118163003075 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 118163003076 multimer interface [polypeptide binding]; other site 118163003077 active site 118163003078 catalytic triad [active] 118163003079 protein interface 1 [polypeptide binding]; other site 118163003080 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 118163003081 homodimer interface [polypeptide binding]; other site 118163003082 NAD binding pocket [chemical binding]; other site 118163003083 ATP binding pocket [chemical binding]; other site 118163003084 Mg binding site [ion binding]; other site 118163003085 active-site loop [active] 118163003086 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 118163003087 nudix motif; other site 118163003088 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 118163003089 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 118163003090 active site 118163003091 (T/H)XGH motif; other site 118163003092 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 118163003093 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 118163003094 active site 118163003095 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 118163003096 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 118163003097 Part of AAA domain; Region: AAA_19; pfam13245 118163003098 Family description; Region: UvrD_C_2; pfam13538 118163003099 Family description; Region: UvrD_C_2; pfam13538 118163003100 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 118163003101 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163003102 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 118163003103 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 118163003104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163003105 Zn2+ binding site [ion binding]; other site 118163003106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 118163003107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163003108 NAD(P) binding site [chemical binding]; other site 118163003109 active site 118163003110 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 118163003111 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163003112 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003113 TPR repeat; Region: TPR_11; pfam13414 118163003114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163003115 TPR motif; other site 118163003116 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 118163003117 GSH binding site [chemical binding]; other site 118163003118 catalytic residues [active] 118163003119 glutathione synthetase; Provisional; Region: PRK05246 118163003120 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 118163003121 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 118163003122 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 118163003123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 118163003124 Walker A/P-loop; other site 118163003125 ATP binding site [chemical binding]; other site 118163003126 Q-loop/lid; other site 118163003127 ABC transporter signature motif; other site 118163003128 Walker B; other site 118163003129 D-loop; other site 118163003130 H-loop/switch region; other site 118163003131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 118163003132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 118163003133 Walker A/P-loop; other site 118163003134 ATP binding site [chemical binding]; other site 118163003135 Q-loop/lid; other site 118163003136 ABC transporter signature motif; other site 118163003137 Walker B; other site 118163003138 D-loop; other site 118163003139 H-loop/switch region; other site 118163003140 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 118163003141 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 118163003142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163003143 Zn2+ binding site [ion binding]; other site 118163003144 Mg2+ binding site [ion binding]; other site 118163003145 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 118163003146 synthetase active site [active] 118163003147 NTP binding site [chemical binding]; other site 118163003148 metal binding site [ion binding]; metal-binding site 118163003149 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 118163003150 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 118163003151 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 118163003152 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 118163003153 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 118163003154 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 118163003155 mce related protein; Region: MCE; pfam02470 118163003156 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 118163003157 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 118163003158 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 118163003159 Walker A/P-loop; other site 118163003160 ATP binding site [chemical binding]; other site 118163003161 Q-loop/lid; other site 118163003162 ABC transporter signature motif; other site 118163003163 Walker B; other site 118163003164 D-loop; other site 118163003165 H-loop/switch region; other site 118163003166 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 118163003167 AAA ATPase domain; Region: AAA_16; pfam13191 118163003168 Walker A motif; other site 118163003169 ATP binding site [chemical binding]; other site 118163003170 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 118163003171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 118163003172 putative NAD(P) binding site [chemical binding]; other site 118163003173 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 118163003174 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 118163003175 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 118163003176 putative dimer interface [polypeptide binding]; other site 118163003177 N-terminal domain interface [polypeptide binding]; other site 118163003178 putative substrate binding pocket (H-site) [chemical binding]; other site 118163003179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163003180 Coenzyme A binding pocket [chemical binding]; other site 118163003181 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163003182 putative binding surface; other site 118163003183 active site 118163003184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163003185 ATP binding site [chemical binding]; other site 118163003186 Mg2+ binding site [ion binding]; other site 118163003187 G-X-G motif; other site 118163003188 Response regulator receiver domain; Region: Response_reg; pfam00072 118163003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003190 active site 118163003191 phosphorylation site [posttranslational modification] 118163003192 intermolecular recognition site; other site 118163003193 dimerization interface [polypeptide binding]; other site 118163003194 Cache domain; Region: Cache_1; pfam02743 118163003195 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 118163003196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163003197 dimer interface [polypeptide binding]; other site 118163003198 putative CheW interface [polypeptide binding]; other site 118163003199 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 118163003200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163003201 dimerization interface [polypeptide binding]; other site 118163003202 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163003203 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163003204 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163003205 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 118163003206 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 118163003207 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 118163003208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163003209 dimer interface [polypeptide binding]; other site 118163003210 putative CheW interface [polypeptide binding]; other site 118163003211 CheW-like domain; Region: CheW; pfam01584 118163003212 Response regulator receiver domain; Region: Response_reg; pfam00072 118163003213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003214 active site 118163003215 phosphorylation site [posttranslational modification] 118163003216 intermolecular recognition site; other site 118163003217 dimerization interface [polypeptide binding]; other site 118163003218 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163003219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003220 active site 118163003221 phosphorylation site [posttranslational modification] 118163003222 intermolecular recognition site; other site 118163003223 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163003224 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 118163003225 active site 118163003226 metal binding site [ion binding]; metal-binding site 118163003227 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 118163003228 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 118163003229 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 118163003230 trimer interface [polypeptide binding]; other site 118163003231 putative metal binding site [ion binding]; other site 118163003232 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 118163003233 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 118163003234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163003235 Probable transposase; Region: OrfB_IS605; pfam01385 118163003236 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163003237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003238 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163003239 hypothetical protein; Provisional; Region: PRK04323 118163003240 Guanylate kinase; Region: Guanylate_kin; pfam00625 118163003241 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 118163003242 catalytic site [active] 118163003243 G-X2-G-X-G-K; other site 118163003244 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 118163003245 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 118163003246 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 118163003247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 118163003248 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 118163003249 Uncharacterized conserved protein [Function unknown]; Region: COG2308 118163003250 Predicted membrane protein/domain [Function unknown]; Region: COG1714 118163003251 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 118163003252 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 118163003253 Protein of unknown function DUF58; Region: DUF58; pfam01882 118163003254 von Willebrand factor type A domain; Region: VWA_2; pfam13519 118163003255 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 118163003256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163003257 Walker A motif; other site 118163003258 ATP binding site [chemical binding]; other site 118163003259 Walker B motif; other site 118163003260 arginine finger; other site 118163003261 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 118163003262 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 118163003263 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 118163003264 dimer interface [polypeptide binding]; other site 118163003265 catalytic triad [active] 118163003266 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 118163003267 DctM-like transporters; Region: DctM; pfam06808 118163003268 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 118163003269 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 118163003270 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 118163003271 catalytic residues [active] 118163003272 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 118163003273 PLD-like domain; Region: PLDc_2; pfam13091 118163003274 putative active site [active] 118163003275 catalytic site [active] 118163003276 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 118163003277 PLD-like domain; Region: PLDc_2; pfam13091 118163003278 putative active site [active] 118163003279 catalytic site [active] 118163003280 Helix-hairpin-helix motif; Region: HHH; pfam00633 118163003281 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 118163003282 Rhomboid family; Region: Rhomboid; pfam01694 118163003283 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 118163003284 trimer interface [polypeptide binding]; other site 118163003285 active site 118163003286 tetrahydromethanopterin S-methyltransferase subunit A; Provisional; Region: PRK00964 118163003287 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 118163003288 dimerization interface [polypeptide binding]; other site 118163003289 active site 118163003290 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 118163003291 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163003292 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163003293 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 118163003294 Ligand Binding Site [chemical binding]; other site 118163003295 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 118163003296 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 118163003297 putative active site [active] 118163003298 putative dimer interface [polypeptide binding]; other site 118163003299 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 118163003300 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 118163003301 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 118163003302 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 118163003303 Competence protein; Region: Competence; pfam03772 118163003304 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 118163003305 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 118163003306 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 118163003307 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 118163003308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 118163003309 ABC-ATPase subunit interface; other site 118163003310 dimer interface [polypeptide binding]; other site 118163003311 putative PBP binding regions; other site 118163003312 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 118163003313 Part of AAA domain; Region: AAA_19; pfam13245 118163003314 Family description; Region: UvrD_C_2; pfam13538 118163003315 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 118163003316 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163003317 catalytic residues [active] 118163003318 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 118163003319 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 118163003320 dinuclear metal binding motif [ion binding]; other site 118163003321 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 118163003322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 118163003323 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 118163003324 catalytic residue [active] 118163003325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 118163003326 pyrroline-5-carboxylate reductase; Region: PLN02688 118163003327 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 118163003328 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 118163003329 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 118163003330 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 118163003331 30S ribosomal protein S1; Reviewed; Region: PRK07400 118163003332 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 118163003333 RNA binding site [nucleotide binding]; other site 118163003334 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 118163003335 RNA binding site [nucleotide binding]; other site 118163003336 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 118163003337 RNA binding site [nucleotide binding]; other site 118163003338 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 118163003339 ATP cone domain; Region: ATP-cone; pfam03477 118163003340 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 118163003341 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 118163003342 Amidinotransferase; Region: Amidinotransf; cl12043 118163003343 Uncharacterized conserved protein [Function unknown]; Region: COG1915 118163003344 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 118163003345 homodimer interface [polypeptide binding]; other site 118163003346 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 118163003347 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 118163003348 putative active site; other site 118163003349 catalytic residue [active] 118163003350 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 118163003351 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 118163003352 Walker A/P-loop; other site 118163003353 ATP binding site [chemical binding]; other site 118163003354 Q-loop/lid; other site 118163003355 ABC transporter signature motif; other site 118163003356 Walker B; other site 118163003357 D-loop; other site 118163003358 H-loop/switch region; other site 118163003359 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 118163003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163003361 dimer interface [polypeptide binding]; other site 118163003362 conserved gate region; other site 118163003363 putative PBP binding loops; other site 118163003364 ABC-ATPase subunit interface; other site 118163003365 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 118163003366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163003367 dimer interface [polypeptide binding]; other site 118163003368 conserved gate region; other site 118163003369 putative PBP binding loops; other site 118163003370 ABC-ATPase subunit interface; other site 118163003371 phosphate binding protein; Region: ptsS_2; TIGR02136 118163003372 Clp protease ATP binding subunit; Region: clpC; CHL00095 118163003373 Clp amino terminal domain; Region: Clp_N; pfam02861 118163003374 Clp amino terminal domain; Region: Clp_N; pfam02861 118163003375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163003376 Walker A motif; other site 118163003377 ATP binding site [chemical binding]; other site 118163003378 Walker B motif; other site 118163003379 arginine finger; other site 118163003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163003381 Walker A motif; other site 118163003382 ATP binding site [chemical binding]; other site 118163003383 Walker B motif; other site 118163003384 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 118163003385 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 118163003386 Domain of unknown function (DUF364); Region: DUF364; pfam04016 118163003387 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 118163003388 Bacterial SH3 domain homologues; Region: SH3b; smart00287 118163003389 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 118163003390 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 118163003391 active site 118163003392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 118163003393 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163003394 Walker A/P-loop; other site 118163003395 ATP binding site [chemical binding]; other site 118163003396 Q-loop/lid; other site 118163003397 ABC transporter signature motif; other site 118163003398 Walker B; other site 118163003399 D-loop; other site 118163003400 H-loop/switch region; other site 118163003401 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 118163003402 Glycoprotease family; Region: Peptidase_M22; pfam00814 118163003403 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 118163003404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163003405 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 118163003406 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 118163003407 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 118163003408 G-X-X-G motif; other site 118163003409 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 118163003410 RxxxH motif; other site 118163003411 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 118163003412 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 118163003413 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 118163003414 Bacterial PH domain; Region: DUF304; pfam03703 118163003415 ribonuclease P; Reviewed; Region: rnpA; PRK03031 118163003416 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 118163003417 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 118163003418 homotrimer interaction site [polypeptide binding]; other site 118163003419 active site 118163003420 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 118163003421 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 118163003422 tandem repeat interface [polypeptide binding]; other site 118163003423 oligomer interface [polypeptide binding]; other site 118163003424 active site residues [active] 118163003425 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 118163003426 EamA-like transporter family; Region: EamA; pfam00892 118163003427 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 118163003428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 118163003429 putative acyl-acceptor binding pocket; other site 118163003430 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 118163003431 Cytochrome P450; Region: p450; pfam00067 118163003432 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163003433 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 118163003434 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 118163003435 tandem repeat interface [polypeptide binding]; other site 118163003436 oligomer interface [polypeptide binding]; other site 118163003437 active site residues [active] 118163003438 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 118163003439 tandem repeat interface [polypeptide binding]; other site 118163003440 oligomer interface [polypeptide binding]; other site 118163003441 active site residues [active] 118163003442 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 118163003443 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 118163003444 homotetramer interface [polypeptide binding]; other site 118163003445 FMN binding site [chemical binding]; other site 118163003446 homodimer contacts [polypeptide binding]; other site 118163003447 putative active site [active] 118163003448 putative substrate binding site [chemical binding]; other site 118163003449 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 118163003450 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 118163003451 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163003452 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 118163003453 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 118163003454 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 118163003455 RNase_H superfamily; Region: RNase_H_2; pfam13482 118163003456 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 118163003457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163003458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163003459 catalytic residue [active] 118163003460 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163003461 putative active site [active] 118163003462 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 118163003463 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 118163003464 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 118163003465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163003466 dimer interface [polypeptide binding]; other site 118163003467 conserved gate region; other site 118163003468 putative PBP binding loops; other site 118163003469 ABC-ATPase subunit interface; other site 118163003470 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 118163003471 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 118163003472 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 118163003473 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 118163003474 dihydropteroate synthase; Region: DHPS; TIGR01496 118163003475 substrate binding pocket [chemical binding]; other site 118163003476 dimer interface [polypeptide binding]; other site 118163003477 inhibitor binding site; inhibition site 118163003478 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 118163003479 triosephosphate isomerase; Provisional; Region: PRK14565 118163003480 dimer interface [polypeptide binding]; other site 118163003481 substrate binding site [chemical binding]; other site 118163003482 catalytic triad [active] 118163003483 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 118163003484 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 118163003485 tetramerization interface [polypeptide binding]; other site 118163003486 active site 118163003487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003488 S-adenosylmethionine binding site [chemical binding]; other site 118163003489 Rubrerythrin [Energy production and conversion]; Region: COG1592 118163003490 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 118163003491 binuclear metal center [ion binding]; other site 118163003492 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 118163003493 iron binding site [ion binding]; other site 118163003494 methionine aminopeptidase; Provisional; Region: PRK08671 118163003495 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 118163003496 active site 118163003497 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 118163003498 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 118163003499 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 118163003500 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 118163003501 metal-binding site [ion binding] 118163003502 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163003503 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163003504 Domain of unknown function (DUF305); Region: DUF305; pfam03713 118163003505 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 118163003506 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 118163003507 Multicopper oxidase; Region: Cu-oxidase; pfam00394 118163003508 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 118163003509 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 118163003510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163003511 Walker A/P-loop; other site 118163003512 ATP binding site [chemical binding]; other site 118163003513 ABC transporter signature motif; other site 118163003514 Response regulator receiver domain; Region: Response_reg; pfam00072 118163003515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003516 active site 118163003517 phosphorylation site [posttranslational modification] 118163003518 intermolecular recognition site; other site 118163003519 dimerization interface [polypeptide binding]; other site 118163003520 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163003521 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163003522 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163003523 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163003524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163003525 putative active site [active] 118163003526 heme pocket [chemical binding]; other site 118163003527 PAS fold; Region: PAS_3; pfam08447 118163003528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163003529 putative active site [active] 118163003530 heme pocket [chemical binding]; other site 118163003531 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163003532 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163003533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163003534 dimer interface [polypeptide binding]; other site 118163003535 phosphorylation site [posttranslational modification] 118163003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163003537 ATP binding site [chemical binding]; other site 118163003538 Mg2+ binding site [ion binding]; other site 118163003539 G-X-G motif; other site 118163003540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003541 active site 118163003542 phosphorylation site [posttranslational modification] 118163003543 intermolecular recognition site; other site 118163003544 Response regulator receiver domain; Region: Response_reg; pfam00072 118163003545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003546 active site 118163003547 phosphorylation site [posttranslational modification] 118163003548 intermolecular recognition site; other site 118163003549 dimerization interface [polypeptide binding]; other site 118163003550 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163003551 putative binding surface; other site 118163003552 active site 118163003553 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163003554 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163003555 active site 118163003556 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 118163003557 tocopherol O-methyltransferase; Region: PLN02244 118163003558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003559 S-adenosylmethionine binding site [chemical binding]; other site 118163003560 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 118163003561 dimerization interface [polypeptide binding]; other site 118163003562 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 118163003563 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 118163003564 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 118163003565 THF binding site; other site 118163003566 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 118163003567 substrate binding site [chemical binding]; other site 118163003568 THF binding site; other site 118163003569 zinc-binding site [ion binding]; other site 118163003570 Predicted metal-binding protein [Function unknown]; Region: COG5469 118163003571 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 118163003572 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 118163003573 PIN domain; Region: PIN; pfam01850 118163003574 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 118163003575 Subunit I/III interface [polypeptide binding]; other site 118163003576 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 118163003577 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 118163003578 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 118163003579 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 118163003580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 118163003581 Predicted membrane protein [Function unknown]; Region: COG4244 118163003582 Predicted membrane protein [Function unknown]; Region: COG4244 118163003583 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163003584 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 118163003585 Zn binding site [ion binding]; other site 118163003586 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 118163003587 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163003588 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163003589 putative active site [active] 118163003590 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 118163003591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 118163003592 inhibitor-cofactor binding pocket; inhibition site 118163003593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163003594 catalytic residue [active] 118163003595 light-harvesting-like protein 3; Provisional; Region: PLN00014 118163003596 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 118163003597 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163003598 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163003599 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163003600 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 118163003601 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 118163003602 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 118163003603 anti sigma factor interaction site; other site 118163003604 regulatory phosphorylation site [posttranslational modification]; other site 118163003605 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163003606 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163003607 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 118163003608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 118163003609 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 118163003610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003611 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163003612 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 118163003613 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 118163003614 Probable transposase; Region: OrfB_IS605; pfam01385 118163003615 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163003616 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 118163003617 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163003618 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 118163003619 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 118163003620 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 118163003621 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 118163003622 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 118163003623 active site 118163003624 catalytic residues [active] 118163003625 metal binding site [ion binding]; metal-binding site 118163003626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 118163003627 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 118163003628 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 118163003629 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 118163003630 active site 118163003631 homodimer interface [polypeptide binding]; other site 118163003632 catalytic site [active] 118163003633 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 118163003634 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 118163003635 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 118163003636 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163003637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003638 S-adenosylmethionine binding site [chemical binding]; other site 118163003639 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 118163003640 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 118163003641 VanZ like family; Region: VanZ; pfam04892 118163003642 Predicted dehydrogenase [General function prediction only]; Region: COG0579 118163003643 hydroxyglutarate oxidase; Provisional; Region: PRK11728 118163003644 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163003645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163003646 active site 118163003647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163003649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163003650 Methyltransferase domain; Region: Methyltransf_12; pfam08242 118163003651 S-adenosylmethionine binding site [chemical binding]; other site 118163003652 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 118163003653 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 118163003654 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 118163003655 putative substrate binding pocket [chemical binding]; other site 118163003656 dimer interface [polypeptide binding]; other site 118163003657 phosphate binding site [ion binding]; other site 118163003658 Family description; Region: VCBS; pfam13517 118163003659 Family description; Region: VCBS; pfam13517 118163003660 Family description; Region: VCBS; pfam13517 118163003661 Family description; Region: VCBS; pfam13517 118163003662 Family description; Region: VCBS; pfam13517 118163003663 Family description; Region: VCBS; pfam13517 118163003664 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163003665 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 118163003666 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163003667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003668 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 118163003669 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163003670 Methyltransferase domain; Region: Methyltransf_12; pfam08242 118163003671 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 118163003672 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 118163003673 FAD binding site [chemical binding]; other site 118163003674 S-adenosylmethionine synthetase; Validated; Region: PRK05250 118163003675 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 118163003676 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 118163003677 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 118163003678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163003679 extended (e) SDRs; Region: SDR_e; cd08946 118163003680 NAD(P) binding site [chemical binding]; other site 118163003681 active site 118163003682 substrate binding site [chemical binding]; other site 118163003683 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 118163003684 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 118163003685 substrate binding site; other site 118163003686 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 118163003687 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 118163003688 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 118163003689 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 118163003690 Exostosin family; Region: Exostosin; pfam03016 118163003691 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163003692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003693 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163003694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003695 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163003696 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 118163003697 active site 118163003698 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163003699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163003702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003703 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 118163003704 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163003705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163003706 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163003707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163003708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003709 S-adenosylmethionine binding site [chemical binding]; other site 118163003710 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 118163003711 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 118163003712 inhibitor-cofactor binding pocket; inhibition site 118163003713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163003714 catalytic residue [active] 118163003715 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 118163003716 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 118163003717 Ligand binding site; other site 118163003718 metal-binding site 118163003719 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163003720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163003721 Walker A/P-loop; other site 118163003722 ATP binding site [chemical binding]; other site 118163003723 Q-loop/lid; other site 118163003724 ABC transporter signature motif; other site 118163003725 Walker B; other site 118163003726 D-loop; other site 118163003727 H-loop/switch region; other site 118163003728 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003729 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163003730 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003731 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003732 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163003733 Chain length determinant protein; Region: Wzz; pfam02706 118163003734 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 118163003735 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163003736 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 118163003737 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 118163003738 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 118163003739 SLBB domain; Region: SLBB; pfam10531 118163003740 Uncharacterized conserved protein [Function unknown]; Region: COG1262 118163003741 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 118163003742 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 118163003743 nickel binding site [ion binding]; other site 118163003744 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 118163003745 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 118163003746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163003747 ATP binding site [chemical binding]; other site 118163003748 putative Mg++ binding site [ion binding]; other site 118163003749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163003750 nucleotide binding region [chemical binding]; other site 118163003751 ATP-binding site [chemical binding]; other site 118163003752 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 118163003753 HRDC domain; Region: HRDC; pfam00570 118163003754 HTH domain; Region: HTH_22; pfam13309 118163003755 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 118163003756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163003757 dimerization interface [polypeptide binding]; other site 118163003758 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 118163003759 PAS domain; Region: PAS; smart00091 118163003760 putative active site [active] 118163003761 heme pocket [chemical binding]; other site 118163003762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163003763 dimer interface [polypeptide binding]; other site 118163003764 phosphorylation site [posttranslational modification] 118163003765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163003766 ATP binding site [chemical binding]; other site 118163003767 Mg2+ binding site [ion binding]; other site 118163003768 G-X-G motif; other site 118163003769 Cache domain; Region: Cache_1; pfam02743 118163003770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163003771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163003772 dimerization interface [polypeptide binding]; other site 118163003773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163003774 dimer interface [polypeptide binding]; other site 118163003775 phosphorylation site [posttranslational modification] 118163003776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163003777 ATP binding site [chemical binding]; other site 118163003778 Mg2+ binding site [ion binding]; other site 118163003779 G-X-G motif; other site 118163003780 Response regulator receiver domain; Region: Response_reg; pfam00072 118163003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163003782 active site 118163003783 phosphorylation site [posttranslational modification] 118163003784 intermolecular recognition site; other site 118163003785 dimerization interface [polypeptide binding]; other site 118163003786 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 118163003787 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163003788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163003789 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 118163003790 putative metal binding site; other site 118163003791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 118163003792 TPR motif; other site 118163003793 binding surface 118163003794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163003795 binding surface 118163003796 TPR repeat; Region: TPR_11; pfam13414 118163003797 TPR motif; other site 118163003798 TPR repeat; Region: TPR_11; pfam13414 118163003799 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 118163003800 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 118163003801 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163003802 Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194 118163003803 DNA methylase; Region: N6_N4_Mtase; cl17433 118163003804 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 118163003805 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 118163003806 active site 118163003807 dimer interface [polypeptide binding]; other site 118163003808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163003809 active site 118163003810 CTP synthetase; Validated; Region: pyrG; PRK05380 118163003811 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 118163003812 Catalytic site [active] 118163003813 active site 118163003814 UTP binding site [chemical binding]; other site 118163003815 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 118163003816 active site 118163003817 putative oxyanion hole; other site 118163003818 catalytic triad [active] 118163003819 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 118163003820 putative active site pocket [active] 118163003821 dimerization interface [polypeptide binding]; other site 118163003822 putative catalytic residue [active] 118163003823 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 118163003824 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 118163003825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163003826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163003827 DNA binding residues [nucleotide binding] 118163003828 Late competence development protein ComFB; Region: ComFB; pfam10719 118163003829 Sm and related proteins; Region: Sm_like; cl00259 118163003830 heptamer interface [polypeptide binding]; other site 118163003831 Sm1 motif; other site 118163003832 hexamer interface [polypeptide binding]; other site 118163003833 RNA binding site [nucleotide binding]; other site 118163003834 Sm2 motif; other site 118163003835 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 118163003836 diaminopimelate epimerase; Region: PLN02536 118163003837 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 118163003838 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 118163003839 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 118163003840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163003841 FeS/SAM binding site; other site 118163003842 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 118163003843 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163003844 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 118163003845 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163003846 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163003847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 118163003848 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 118163003849 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 118163003850 interchain domain interface [polypeptide binding]; other site 118163003851 intrachain domain interface; other site 118163003852 Qi binding site; other site 118163003853 Qo binding site; other site 118163003854 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 118163003855 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 118163003856 Qi binding site; other site 118163003857 intrachain domain interface; other site 118163003858 interchain domain interface [polypeptide binding]; other site 118163003859 heme bH binding site [chemical binding]; other site 118163003860 heme bL binding site [chemical binding]; other site 118163003861 Qo binding site; other site 118163003862 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 118163003863 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 118163003864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163003865 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 118163003866 acyl-activating enzyme (AAE) consensus motif; other site 118163003867 putative AMP binding site [chemical binding]; other site 118163003868 putative active site [active] 118163003869 putative CoA binding site [chemical binding]; other site 118163003870 urea carboxylase; Region: urea_carbox; TIGR02712 118163003871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163003872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163003873 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 118163003874 active site 118163003875 Int/Topo IB signature motif; other site 118163003876 DNA binding site [nucleotide binding] 118163003877 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 118163003878 Fatty acid desaturase; Region: FA_desaturase; pfam00487 118163003879 Di-iron ligands [ion binding]; other site 118163003880 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163003881 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 118163003882 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163003883 catalytic residue [active] 118163003884 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163003885 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163003886 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 118163003887 aromatic arch; other site 118163003888 DCoH dimer interaction site [polypeptide binding]; other site 118163003889 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 118163003890 DCoH tetramer interaction site [polypeptide binding]; other site 118163003891 substrate binding site [chemical binding]; other site 118163003892 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 118163003893 shikimate kinase; Reviewed; Region: aroK; PRK00131 118163003894 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 118163003895 ADP binding site [chemical binding]; other site 118163003896 magnesium binding site [ion binding]; other site 118163003897 putative shikimate binding site; other site 118163003898 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 118163003899 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 118163003900 active site 118163003901 DNA binding site [nucleotide binding] 118163003902 Int/Topo IB signature motif; other site 118163003903 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 118163003904 Mechanosensitive ion channel; Region: MS_channel; pfam00924 118163003905 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 118163003906 MutS domain I; Region: MutS_I; pfam01624 118163003907 MutS domain II; Region: MutS_II; pfam05188 118163003908 MutS domain III; Region: MutS_III; pfam05192 118163003909 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 118163003910 Walker A/P-loop; other site 118163003911 ATP binding site [chemical binding]; other site 118163003912 Q-loop/lid; other site 118163003913 ABC transporter signature motif; other site 118163003914 Walker B; other site 118163003915 D-loop; other site 118163003916 H-loop/switch region; other site 118163003917 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 118163003918 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 118163003919 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 118163003920 pyruvate kinase; Provisional; Region: PRK06354 118163003921 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 118163003922 domain interfaces; other site 118163003923 active site 118163003924 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 118163003925 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 118163003926 Hemerythrin-like domain; Region: Hr-like; cd12108 118163003927 HEAT repeats; Region: HEAT_2; pfam13646 118163003928 HEAT repeats; Region: HEAT_2; pfam13646 118163003929 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 118163003930 protein binding surface [polypeptide binding]; other site 118163003931 HEAT repeats; Region: HEAT_2; pfam13646 118163003932 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 118163003933 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 118163003934 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 118163003935 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 118163003936 HEAT repeats; Region: HEAT_2; pfam13646 118163003937 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 118163003938 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 118163003939 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 118163003940 metal binding site [ion binding]; metal-binding site 118163003941 dimer interface [polypeptide binding]; other site 118163003942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163003943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163003944 phosphorylation site [posttranslational modification] 118163003945 dimer interface [polypeptide binding]; other site 118163003946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163003947 ATP binding site [chemical binding]; other site 118163003948 Mg2+ binding site [ion binding]; other site 118163003949 G-X-G motif; other site 118163003950 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 118163003951 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 118163003952 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163003953 Chain length determinant protein; Region: Wzz; pfam02706 118163003954 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 118163003955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163003956 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 118163003957 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 118163003958 SLBB domain; Region: SLBB; pfam10531 118163003959 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 118163003960 SLBB domain; Region: SLBB; pfam10531 118163003961 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 118163003962 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 118163003963 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 118163003964 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 118163003965 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 118163003966 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 118163003967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163003968 Uncharacterized conserved protein [Function unknown]; Region: COG1262 118163003969 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 118163003970 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 118163003971 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 118163003972 active site 118163003973 dimer interface [polypeptide binding]; other site 118163003974 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 118163003975 dimer interface [polypeptide binding]; other site 118163003976 active site 118163003977 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 118163003978 homodimer interface [polypeptide binding]; other site 118163003979 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 118163003980 active site pocket [active] 118163003981 Homeodomain-like domain; Region: HTH_23; pfam13384 118163003982 Winged helix-turn helix; Region: HTH_29; pfam13551 118163003983 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 118163003984 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163003985 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163003986 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163003987 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003988 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163003989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163003990 S-adenosylmethionine binding site [chemical binding]; other site 118163003991 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 118163003992 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 118163003993 Ligand binding site; other site 118163003994 Putative Catalytic site; other site 118163003995 DXD motif; other site 118163003996 Predicted membrane protein [Function unknown]; Region: COG2246 118163003997 GtrA-like protein; Region: GtrA; pfam04138 118163003998 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163003999 Predicted integral membrane protein [Function unknown]; Region: COG5617 118163004000 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 118163004001 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 118163004002 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 118163004003 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 118163004004 glutamine binding [chemical binding]; other site 118163004005 catalytic triad [active] 118163004006 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 118163004007 metal-binding heat shock protein; Provisional; Region: PRK00016 118163004008 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 118163004009 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 118163004010 putative lipid kinase; Reviewed; Region: PRK13057 118163004011 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 118163004012 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 118163004013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163004014 Walker A/P-loop; other site 118163004015 ATP binding site [chemical binding]; other site 118163004016 Q-loop/lid; other site 118163004017 ABC transporter signature motif; other site 118163004018 Walker B; other site 118163004019 D-loop; other site 118163004020 H-loop/switch region; other site 118163004021 TOBE domain; Region: TOBE_2; pfam08402 118163004022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163004023 dimerization interface [polypeptide binding]; other site 118163004024 putative DNA binding site [nucleotide binding]; other site 118163004025 putative Zn2+ binding site [ion binding]; other site 118163004026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 118163004027 conserved hypothetical protein; Region: TIGR03492 118163004028 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 118163004029 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 118163004030 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 118163004031 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 118163004032 dimerization interface [polypeptide binding]; other site 118163004033 active site 118163004034 RDD family; Region: RDD; pfam06271 118163004035 Protein of unknown function DUF72; Region: DUF72; pfam01904 118163004036 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 118163004037 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 118163004038 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 118163004039 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 118163004040 putative GSH binding site [chemical binding]; other site 118163004041 catalytic residues [active] 118163004042 BolA-like protein; Region: BolA; pfam01722 118163004043 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 118163004044 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 118163004045 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 118163004046 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 118163004047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163004048 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 118163004049 Probable transposase; Region: OrfB_IS605; pfam01385 118163004050 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 118163004051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163004052 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 118163004053 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 118163004054 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 118163004055 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 118163004056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 118163004057 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 118163004058 substrate binding pocket [chemical binding]; other site 118163004059 membrane-bound complex binding site; other site 118163004060 hinge residues; other site 118163004061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163004062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004063 binding surface 118163004064 TPR motif; other site 118163004065 TPR repeat; Region: TPR_11; pfam13414 118163004066 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 118163004067 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 118163004068 putative ADP-binding pocket [chemical binding]; other site 118163004069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163004070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163004071 NAD(P) binding site [chemical binding]; other site 118163004072 active site 118163004073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 118163004074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 118163004075 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163004076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163004077 active site 118163004078 Predicted membrane protein [Function unknown]; Region: COG3431 118163004079 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163004080 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163004081 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 118163004082 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 118163004083 Sulfate transporter family; Region: Sulfate_transp; pfam00916 118163004084 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 118163004085 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163004086 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 118163004087 Walker A/P-loop; other site 118163004088 ATP binding site [chemical binding]; other site 118163004089 Q-loop/lid; other site 118163004090 ABC transporter signature motif; other site 118163004091 Walker B; other site 118163004092 D-loop; other site 118163004093 H-loop/switch region; other site 118163004094 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163004095 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 118163004096 Walker A/P-loop; other site 118163004097 ATP binding site [chemical binding]; other site 118163004098 Q-loop/lid; other site 118163004099 ABC transporter signature motif; other site 118163004100 Walker B; other site 118163004101 D-loop; other site 118163004102 H-loop/switch region; other site 118163004103 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 118163004104 NMT1-like family; Region: NMT1_2; pfam13379 118163004105 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 118163004106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163004107 dimer interface [polypeptide binding]; other site 118163004108 conserved gate region; other site 118163004109 ABC-ATPase subunit interface; other site 118163004110 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 118163004111 NMT1-like family; Region: NMT1_2; pfam13379 118163004112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163004114 dimerization interface [polypeptide binding]; other site 118163004115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004116 dimer interface [polypeptide binding]; other site 118163004117 phosphorylation site [posttranslational modification] 118163004118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004119 ATP binding site [chemical binding]; other site 118163004120 Mg2+ binding site [ion binding]; other site 118163004121 G-X-G motif; other site 118163004122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004124 active site 118163004125 phosphorylation site [posttranslational modification] 118163004126 intermolecular recognition site; other site 118163004127 dimerization interface [polypeptide binding]; other site 118163004128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163004129 DNA binding site [nucleotide binding] 118163004130 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 118163004131 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163004132 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 118163004133 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 118163004134 putative active site [active] 118163004135 Zn binding site [ion binding]; other site 118163004136 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 118163004137 RimK-like ATP-grasp domain; Region: RimK; pfam08443 118163004138 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 118163004139 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 118163004140 B12 binding site [chemical binding]; other site 118163004141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163004142 FeS/SAM binding site; other site 118163004143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 118163004144 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 118163004145 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 118163004146 anti sigma factor interaction site; other site 118163004147 regulatory phosphorylation site [posttranslational modification]; other site 118163004148 Homeodomain-like domain; Region: HTH_23; pfam13384 118163004149 Winged helix-turn helix; Region: HTH_29; pfam13551 118163004150 Homeodomain-like domain; Region: HTH_32; pfam13565 118163004151 Predicted permeases [General function prediction only]; Region: COG0701 118163004152 TIGR03943 family protein; Region: TIGR03943 118163004153 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 118163004154 16S/18S rRNA binding site [nucleotide binding]; other site 118163004155 S13e-L30e interaction site [polypeptide binding]; other site 118163004156 25S rRNA binding site [nucleotide binding]; other site 118163004157 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 118163004158 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 118163004159 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 118163004160 quinolinate synthetase; Provisional; Region: PRK09375 118163004161 CheW-like domain; Region: CheW; pfam01584 118163004162 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163004163 putative binding surface; other site 118163004164 active site 118163004165 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 118163004166 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 118163004167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004168 ATP binding site [chemical binding]; other site 118163004169 Mg2+ binding site [ion binding]; other site 118163004170 G-X-G motif; other site 118163004171 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 118163004172 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163004173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004174 active site 118163004175 phosphorylation site [posttranslational modification] 118163004176 intermolecular recognition site; other site 118163004177 dimerization interface [polypeptide binding]; other site 118163004178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163004179 dimerization interface [polypeptide binding]; other site 118163004180 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163004181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163004182 dimer interface [polypeptide binding]; other site 118163004183 putative CheW interface [polypeptide binding]; other site 118163004184 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 118163004185 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004187 active site 118163004188 phosphorylation site [posttranslational modification] 118163004189 intermolecular recognition site; other site 118163004190 dimerization interface [polypeptide binding]; other site 118163004191 HEAT repeats; Region: HEAT_2; pfam13646 118163004192 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 118163004193 HEAT repeats; Region: HEAT_2; pfam13646 118163004194 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 118163004195 HEAT repeats; Region: HEAT_2; pfam13646 118163004196 S-layer homology domain; Region: SLH; pfam00395 118163004197 S-layer homology domain; Region: SLH; pfam00395 118163004198 S-layer homology domain; Region: SLH; pfam00395 118163004199 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 118163004200 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 118163004201 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 118163004202 Clp amino terminal domain; Region: Clp_N; pfam02861 118163004203 Clp amino terminal domain; Region: Clp_N; pfam02861 118163004204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163004205 Walker A motif; other site 118163004206 ATP binding site [chemical binding]; other site 118163004207 Walker B motif; other site 118163004208 arginine finger; other site 118163004209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163004210 Walker A motif; other site 118163004211 ATP binding site [chemical binding]; other site 118163004212 Walker B motif; other site 118163004213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 118163004214 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 118163004215 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 118163004216 23S rRNA binding site [nucleotide binding]; other site 118163004217 L21 binding site [polypeptide binding]; other site 118163004218 L13 binding site [polypeptide binding]; other site 118163004219 Predicted integral membrane protein [Function unknown]; Region: COG0762 118163004220 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 118163004221 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 118163004222 putative active site [active] 118163004223 putative metal binding site [ion binding]; other site 118163004224 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 118163004225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163004226 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163004227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163004228 active site 118163004229 ATP binding site [chemical binding]; other site 118163004230 substrate binding site [chemical binding]; other site 118163004231 activation loop (A-loop); other site 118163004232 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 118163004233 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004235 active site 118163004236 phosphorylation site [posttranslational modification] 118163004237 intermolecular recognition site; other site 118163004238 dimerization interface [polypeptide binding]; other site 118163004239 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163004240 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163004241 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 118163004242 GIY-YIG motif/motif A; other site 118163004243 Uncharacterized conserved protein [Function unknown]; Region: COG1432 118163004244 LabA_like proteins; Region: LabA; cd10911 118163004245 putative metal binding site [ion binding]; other site 118163004246 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163004247 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004249 active site 118163004250 phosphorylation site [posttranslational modification] 118163004251 intermolecular recognition site; other site 118163004252 dimerization interface [polypeptide binding]; other site 118163004253 CHASE domain; Region: CHASE; cl01369 118163004254 PAS domain; Region: PAS_9; pfam13426 118163004255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163004256 putative active site [active] 118163004257 heme pocket [chemical binding]; other site 118163004258 PAS fold; Region: PAS_4; pfam08448 118163004259 GAF domain; Region: GAF; pfam01590 118163004260 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163004261 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163004262 PAS domain S-box; Region: sensory_box; TIGR00229 118163004263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163004264 putative active site [active] 118163004265 heme pocket [chemical binding]; other site 118163004266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004268 dimer interface [polypeptide binding]; other site 118163004269 phosphorylation site [posttranslational modification] 118163004270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004271 ATP binding site [chemical binding]; other site 118163004272 Mg2+ binding site [ion binding]; other site 118163004273 G-X-G motif; other site 118163004274 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163004275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004276 active site 118163004277 phosphorylation site [posttranslational modification] 118163004278 intermolecular recognition site; other site 118163004279 dimerization interface [polypeptide binding]; other site 118163004280 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163004281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004282 active site 118163004283 phosphorylation site [posttranslational modification] 118163004284 intermolecular recognition site; other site 118163004285 dimerization interface [polypeptide binding]; other site 118163004286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163004287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004288 active site 118163004289 phosphorylation site [posttranslational modification] 118163004290 intermolecular recognition site; other site 118163004291 dimerization interface [polypeptide binding]; other site 118163004292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163004293 DNA binding site [nucleotide binding] 118163004294 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163004295 putative binding surface; other site 118163004296 active site 118163004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004298 active site 118163004299 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 118163004300 phosphorylation site [posttranslational modification] 118163004301 intermolecular recognition site; other site 118163004302 dimerization interface [polypeptide binding]; other site 118163004303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004304 active site 118163004305 phosphorylation site [posttranslational modification] 118163004306 intermolecular recognition site; other site 118163004307 dimerization interface [polypeptide binding]; other site 118163004308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163004309 metal binding site [ion binding]; metal-binding site 118163004310 active site 118163004311 I-site; other site 118163004312 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 118163004313 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163004314 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 118163004315 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 118163004316 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 118163004317 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 118163004318 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 118163004319 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 118163004320 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 118163004321 D-pathway; other site 118163004322 Putative ubiquinol binding site [chemical binding]; other site 118163004323 Low-spin heme (heme b) binding site [chemical binding]; other site 118163004324 Putative water exit pathway; other site 118163004325 Binuclear center (heme o3/CuB) [ion binding]; other site 118163004326 K-pathway; other site 118163004327 Putative proton exit pathway; other site 118163004328 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 118163004329 Subunit I/III interface [polypeptide binding]; other site 118163004330 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163004331 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163004332 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163004333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 118163004334 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 118163004335 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 118163004336 Surface antigen; Region: Bac_surface_Ag; pfam01103 118163004337 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 118163004338 haemagglutination activity domain; Region: Haemagg_act; pfam05860 118163004339 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 118163004340 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163004341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004342 binding surface 118163004343 TPR repeat; Region: TPR_11; pfam13414 118163004344 TPR motif; other site 118163004345 TPR repeat; Region: TPR_11; pfam13414 118163004346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163004347 TPR repeat; Region: TPR_11; pfam13414 118163004348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004349 binding surface 118163004350 TPR motif; other site 118163004351 TPR repeat; Region: TPR_11; pfam13414 118163004352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 118163004353 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 118163004354 TM-ABC transporter signature motif; other site 118163004355 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 118163004356 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 118163004357 putative active site [active] 118163004358 adenylation catalytic residue [active] 118163004359 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 118163004360 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 118163004361 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 118163004362 active site 118163004363 catalytic site [active] 118163004364 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 118163004365 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 118163004366 putative FMN binding site [chemical binding]; other site 118163004367 NADPH bind site [chemical binding]; other site 118163004368 Amidohydrolase; Region: Amidohydro_2; pfam04909 118163004369 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 118163004370 YcaO-like family; Region: YcaO; pfam02624 118163004371 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 118163004372 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 118163004373 active site 118163004374 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 118163004375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163004376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163004377 active site 118163004378 ATP binding site [chemical binding]; other site 118163004379 substrate binding site [chemical binding]; other site 118163004380 activation loop (A-loop); other site 118163004381 AAA ATPase domain; Region: AAA_16; pfam13191 118163004382 Predicted ATPase [General function prediction only]; Region: COG3899 118163004383 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163004384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163004385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004387 dimer interface [polypeptide binding]; other site 118163004388 phosphorylation site [posttranslational modification] 118163004389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004390 ATP binding site [chemical binding]; other site 118163004391 Mg2+ binding site [ion binding]; other site 118163004392 G-X-G motif; other site 118163004393 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004395 active site 118163004396 phosphorylation site [posttranslational modification] 118163004397 intermolecular recognition site; other site 118163004398 dimerization interface [polypeptide binding]; other site 118163004399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004401 ATP binding site [chemical binding]; other site 118163004402 Mg2+ binding site [ion binding]; other site 118163004403 G-X-G motif; other site 118163004404 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163004405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 118163004406 active site 118163004407 metal binding site [ion binding]; metal-binding site 118163004408 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 118163004409 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 118163004410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163004411 active site 118163004412 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 118163004413 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 118163004414 active site 118163004415 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 118163004416 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163004417 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163004418 phosphopeptide binding site; other site 118163004419 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 118163004420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 118163004421 RNA binding surface [nucleotide binding]; other site 118163004422 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 118163004423 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 118163004424 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 118163004425 pantothenate kinase; Reviewed; Region: PRK13331 118163004426 short chain dehydrogenase; Provisional; Region: PRK08219 118163004427 classical (c) SDRs; Region: SDR_c; cd05233 118163004428 NAD(P) binding site [chemical binding]; other site 118163004429 active site 118163004430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 118163004431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163004432 Walker A/P-loop; other site 118163004433 ATP binding site [chemical binding]; other site 118163004434 Q-loop/lid; other site 118163004435 ABC transporter signature motif; other site 118163004436 Walker B; other site 118163004437 D-loop; other site 118163004438 H-loop/switch region; other site 118163004439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 118163004440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163004441 dimer interface [polypeptide binding]; other site 118163004442 conserved gate region; other site 118163004443 putative PBP binding loops; other site 118163004444 ABC-ATPase subunit interface; other site 118163004445 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 118163004446 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 118163004447 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 118163004448 hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100 118163004449 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 118163004450 agmatinase; Region: agmatinase; TIGR01230 118163004451 Agmatinase-like family; Region: Agmatinase-like; cd09990 118163004452 active site 118163004453 oligomer interface [polypeptide binding]; other site 118163004454 Mn binding site [ion binding]; other site 118163004455 ykkC-yxkD leader; IMG reference gene:2509573522; Ple7327_1639 118163004456 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163004457 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163004458 Hexamer interface [polypeptide binding]; other site 118163004459 Hexagonal pore residue; other site 118163004460 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163004461 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163004462 Hexamer interface [polypeptide binding]; other site 118163004463 Hexagonal pore residue; other site 118163004464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163004465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163004466 S-adenosylmethionine binding site [chemical binding]; other site 118163004467 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 118163004468 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 118163004469 substrate binding site [chemical binding]; other site 118163004470 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 118163004471 substrate binding site [chemical binding]; other site 118163004472 ligand binding site [chemical binding]; other site 118163004473 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163004474 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 118163004475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163004476 active site 118163004477 motif I; other site 118163004478 motif II; other site 118163004479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163004480 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 118163004481 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 118163004482 Rhomboid family; Region: Rhomboid; pfam01694 118163004483 hydrolase, alpha/beta fold family protein; Region: PLN02824 118163004484 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 118163004485 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 118163004486 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 118163004487 HAS barrel domain; Region: HAS-barrel; pfam09378 118163004488 HerA helicase [Replication, recombination, and repair]; Region: COG0433 118163004489 Domain of unknown function DUF87; Region: DUF87; pfam01935 118163004490 CAAX protease self-immunity; Region: Abi; pfam02517 118163004491 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 118163004492 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 118163004493 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 118163004494 putative catalytic cysteine [active] 118163004495 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 118163004496 putative active site [active] 118163004497 metal binding site [ion binding]; metal-binding site 118163004498 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 118163004499 endonuclease III; Region: ENDO3c; smart00478 118163004500 minor groove reading motif; other site 118163004501 helix-hairpin-helix signature motif; other site 118163004502 substrate binding pocket [chemical binding]; other site 118163004503 active site 118163004504 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 118163004505 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 118163004506 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 118163004507 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 118163004508 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 118163004509 GatB domain; Region: GatB_Yqey; smart00845 118163004510 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163004511 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163004512 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 118163004513 Ligand Binding Site [chemical binding]; other site 118163004514 Uncharacterized conserved protein [Function unknown]; Region: COG1434 118163004515 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 118163004516 putative active site [active] 118163004517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163004518 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163004519 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 118163004520 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 118163004521 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004523 active site 118163004524 phosphorylation site [posttranslational modification] 118163004525 intermolecular recognition site; other site 118163004526 dimerization interface [polypeptide binding]; other site 118163004527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163004528 metal binding site [ion binding]; metal-binding site 118163004529 active site 118163004530 I-site; other site 118163004531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163004532 Cache domain; Region: Cache_1; pfam02743 118163004533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163004535 dimerization interface [polypeptide binding]; other site 118163004536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004537 dimer interface [polypeptide binding]; other site 118163004538 phosphorylation site [posttranslational modification] 118163004539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004540 ATP binding site [chemical binding]; other site 118163004541 Mg2+ binding site [ion binding]; other site 118163004542 G-X-G motif; other site 118163004543 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163004544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004545 active site 118163004546 phosphorylation site [posttranslational modification] 118163004547 intermolecular recognition site; other site 118163004548 dimerization interface [polypeptide binding]; other site 118163004549 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163004550 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 118163004551 Walker A/P-loop; other site 118163004552 ATP binding site [chemical binding]; other site 118163004553 Q-loop/lid; other site 118163004554 ABC transporter signature motif; other site 118163004555 Walker B; other site 118163004556 D-loop; other site 118163004557 H-loop/switch region; other site 118163004558 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163004559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163004560 Walker A/P-loop; other site 118163004561 ATP binding site [chemical binding]; other site 118163004562 Q-loop/lid; other site 118163004563 ABC transporter signature motif; other site 118163004564 Walker B; other site 118163004565 D-loop; other site 118163004566 H-loop/switch region; other site 118163004567 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163004568 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 118163004569 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 118163004570 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 118163004571 catalytic residues [active] 118163004572 catalytic nucleophile [active] 118163004573 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163004574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163004575 S-adenosylmethionine binding site [chemical binding]; other site 118163004576 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 118163004577 active site 118163004578 catalytic residues [active] 118163004579 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 118163004580 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 118163004581 dimer interface [polypeptide binding]; other site 118163004582 FMN binding site [chemical binding]; other site 118163004583 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 118163004584 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163004585 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163004586 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163004587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163004588 motif II; other site 118163004589 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163004590 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 118163004591 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 118163004592 active site 118163004593 TDP-binding site; other site 118163004594 acceptor substrate-binding pocket; other site 118163004595 homodimer interface [polypeptide binding]; other site 118163004596 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 118163004597 alpha-beta subunit interface [polypeptide binding]; other site 118163004598 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 118163004599 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 118163004600 C-terminal domain interface [polypeptide binding]; other site 118163004601 active site 118163004602 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 118163004603 active site 118163004604 N-terminal domain interface [polypeptide binding]; other site 118163004605 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 118163004606 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 118163004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163004608 FeS/SAM binding site; other site 118163004609 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 118163004610 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 118163004611 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 118163004612 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163004613 Ligand Binding Site [chemical binding]; other site 118163004614 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 118163004615 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 118163004616 anti sigma factor interaction site; other site 118163004617 regulatory phosphorylation site [posttranslational modification]; other site 118163004618 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163004619 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163004620 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 118163004621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 118163004622 putative glycosyl transferase; Provisional; Region: PRK10307 118163004623 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 118163004624 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 118163004625 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 118163004626 active site 118163004627 metal binding site [ion binding]; metal-binding site 118163004628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163004629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163004630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163004631 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 118163004632 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 118163004633 metal-binding site 118163004634 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163004635 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 118163004636 active site 118163004637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163004638 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 118163004639 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 118163004640 putative active site [active] 118163004641 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 118163004642 putative active site [active] 118163004643 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 118163004644 active site 118163004645 SAM binding site [chemical binding]; other site 118163004646 homodimer interface [polypeptide binding]; other site 118163004647 prolyl-tRNA synthetase; Provisional; Region: PRK09194 118163004648 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 118163004649 dimer interface [polypeptide binding]; other site 118163004650 motif 1; other site 118163004651 active site 118163004652 motif 2; other site 118163004653 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 118163004654 putative deacylase active site [active] 118163004655 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 118163004656 active site 118163004657 motif 3; other site 118163004658 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 118163004659 anticodon binding site; other site 118163004660 PAS fold; Region: PAS; pfam00989 118163004661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163004662 putative active site [active] 118163004663 heme pocket [chemical binding]; other site 118163004664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163004665 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163004666 ligand binding site [chemical binding]; other site 118163004667 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 118163004668 putative switch regulator; other site 118163004669 non-specific DNA interactions [nucleotide binding]; other site 118163004670 DNA binding site [nucleotide binding] 118163004671 sequence specific DNA binding site [nucleotide binding]; other site 118163004672 putative cAMP binding site [chemical binding]; other site 118163004673 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 118163004674 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 118163004675 putative active site [active] 118163004676 substrate binding site [chemical binding]; other site 118163004677 putative cosubstrate binding site; other site 118163004678 catalytic site [active] 118163004679 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 118163004680 substrate binding site [chemical binding]; other site 118163004681 Predicted transcriptional regulators [Transcription]; Region: COG1725 118163004682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 118163004683 DNA-binding site [nucleotide binding]; DNA binding site 118163004684 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 118163004685 CAAX protease self-immunity; Region: Abi; pfam02517 118163004686 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 118163004687 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 118163004688 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 118163004689 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 118163004690 FAD binding pocket [chemical binding]; other site 118163004691 FAD binding motif [chemical binding]; other site 118163004692 phosphate binding motif [ion binding]; other site 118163004693 beta-alpha-beta structure motif; other site 118163004694 NAD binding pocket [chemical binding]; other site 118163004695 Predicted membrane protein [Function unknown]; Region: COG1808 118163004696 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 118163004697 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 118163004698 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163004699 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 118163004700 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163004701 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 118163004702 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163004703 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163004704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163004705 motif II; other site 118163004706 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163004707 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 118163004708 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 118163004709 putative ADP-binding pocket [chemical binding]; other site 118163004710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163004711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004712 active site 118163004713 phosphorylation site [posttranslational modification] 118163004714 intermolecular recognition site; other site 118163004715 dimerization interface [polypeptide binding]; other site 118163004716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163004717 DNA binding site [nucleotide binding] 118163004718 CHASE3 domain; Region: CHASE3; pfam05227 118163004719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004721 dimer interface [polypeptide binding]; other site 118163004722 phosphorylation site [posttranslational modification] 118163004723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004724 ATP binding site [chemical binding]; other site 118163004725 Mg2+ binding site [ion binding]; other site 118163004726 G-X-G motif; other site 118163004727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163004728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004729 active site 118163004730 phosphorylation site [posttranslational modification] 118163004731 intermolecular recognition site; other site 118163004732 dimerization interface [polypeptide binding]; other site 118163004733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163004734 DNA binding site [nucleotide binding] 118163004735 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 118163004736 core domain interface [polypeptide binding]; other site 118163004737 delta subunit interface [polypeptide binding]; other site 118163004738 epsilon subunit interface [polypeptide binding]; other site 118163004739 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 118163004740 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 118163004741 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 118163004742 beta subunit interaction interface [polypeptide binding]; other site 118163004743 Walker A motif; other site 118163004744 ATP binding site [chemical binding]; other site 118163004745 Walker B motif; other site 118163004746 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 118163004747 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 118163004748 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 118163004749 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 118163004750 ATP synthase CF0 B subunit; Region: atpF; CHL00019 118163004751 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 118163004752 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 118163004753 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 118163004754 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 118163004755 ATP synthase CF0 A subunit; Region: atpI; CHL00046 118163004756 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 118163004757 Fasciclin domain; Region: Fasciclin; pfam02469 118163004758 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 118163004759 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 118163004760 dimerization interface [polypeptide binding]; other site 118163004761 putative active cleft [active] 118163004762 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 118163004763 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 118163004764 putative active site cavity [active] 118163004765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163004766 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163004767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163004768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163004769 dimer interface [polypeptide binding]; other site 118163004770 phosphorylation site [posttranslational modification] 118163004771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004772 ATP binding site [chemical binding]; other site 118163004773 Mg2+ binding site [ion binding]; other site 118163004774 G-X-G motif; other site 118163004775 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004776 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 118163004777 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163004778 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163004779 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 118163004780 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 118163004781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163004782 Zn2+ binding site [ion binding]; other site 118163004783 Mg2+ binding site [ion binding]; other site 118163004784 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 118163004785 acyl-CoA synthetase; Validated; Region: PRK05850 118163004786 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163004787 acyl-activating enzyme (AAE) consensus motif; other site 118163004788 active site 118163004789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 118163004790 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 118163004791 active site 118163004792 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163004793 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 118163004794 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 118163004795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163004796 NAD(P) binding site [chemical binding]; other site 118163004797 TPR repeat; Region: TPR_11; pfam13414 118163004798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004799 TPR motif; other site 118163004800 binding surface 118163004801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004802 TPR motif; other site 118163004803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163004804 binding surface 118163004805 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163004806 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163004807 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163004808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163004809 active site 118163004810 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163004811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163004812 active site 118163004813 hypothetical protein; Provisional; Region: PRK07208 118163004814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163004815 hydroxyglutarate oxidase; Provisional; Region: PRK11728 118163004816 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 118163004817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163004818 active site 118163004819 DNA gyrase subunit A; Validated; Region: PRK05560 118163004820 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 118163004821 CAP-like domain; other site 118163004822 active site 118163004823 primary dimer interface [polypeptide binding]; other site 118163004824 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004825 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004826 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004827 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004828 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004829 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163004830 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 118163004831 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 118163004832 putative lipid kinase; Reviewed; Region: PRK00861 118163004833 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 118163004834 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 118163004835 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 118163004836 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 118163004837 active site 118163004838 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 118163004839 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 118163004840 Ferritin-like domain; Region: Ferritin; pfam00210 118163004841 dimanganese center [ion binding]; other site 118163004842 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 118163004843 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 118163004844 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 118163004845 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 118163004846 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 118163004847 catalytic residues [active] 118163004848 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 118163004849 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 118163004850 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 118163004851 dimer interface [polypeptide binding]; other site 118163004852 active site 118163004853 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 118163004854 active site 118163004855 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 118163004856 Uncharacterized conserved protein [Function unknown]; Region: COG3391 118163004857 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004858 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004859 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004860 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004861 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004862 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 118163004863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163004864 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 118163004865 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163004866 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163004867 ligand binding site [chemical binding]; other site 118163004868 flexible hinge region; other site 118163004869 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 118163004870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163004871 Walker A motif; other site 118163004872 ATP binding site [chemical binding]; other site 118163004873 Walker B motif; other site 118163004874 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 118163004875 4Fe-4S binding domain; Region: Fer4_5; pfam12801 118163004876 4Fe-4S binding domain; Region: Fer4_5; pfam12801 118163004877 topology modulation protein; Reviewed; Region: PRK08118 118163004878 AAA domain; Region: AAA_17; pfam13207 118163004879 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 118163004880 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 118163004881 NAD binding site [chemical binding]; other site 118163004882 ATP-grasp domain; Region: ATP-grasp; pfam02222 118163004883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163004884 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163004885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163004886 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 118163004887 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 118163004888 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 118163004889 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 118163004890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163004891 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163004892 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163004893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163004894 S-adenosylmethionine binding site [chemical binding]; other site 118163004895 L-type amino acid transporter; Region: 2A0308; TIGR00911 118163004896 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 118163004897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163004898 Ligand Binding Site [chemical binding]; other site 118163004899 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 118163004900 hypothetical protein; Provisional; Region: PRK02509 118163004901 Uncharacterized conserved protein [Function unknown]; Region: COG1615 118163004902 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 118163004903 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 118163004904 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 118163004905 active site 118163004906 HIGH motif; other site 118163004907 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 118163004908 active site 118163004909 KMSKS motif; other site 118163004910 acylphosphatase; Provisional; Region: PRK14423 118163004911 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 118163004912 Cysteine-rich domain; Region: CCG; pfam02754 118163004913 Cysteine-rich domain; Region: CCG; pfam02754 118163004914 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 118163004915 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 118163004916 active site 118163004917 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 118163004918 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 118163004919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163004920 ATP binding site [chemical binding]; other site 118163004921 Mg2+ binding site [ion binding]; other site 118163004922 G-X-G motif; other site 118163004923 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 118163004924 Response regulator receiver domain; Region: Response_reg; pfam00072 118163004925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004926 active site 118163004927 phosphorylation site [posttranslational modification] 118163004928 intermolecular recognition site; other site 118163004929 dimerization interface [polypeptide binding]; other site 118163004930 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163004931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163004932 active site 118163004933 phosphorylation site [posttranslational modification] 118163004934 intermolecular recognition site; other site 118163004935 dimerization interface [polypeptide binding]; other site 118163004936 GTPase Era; Reviewed; Region: era; PRK00089 118163004937 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 118163004938 G1 box; other site 118163004939 GTP/Mg2+ binding site [chemical binding]; other site 118163004940 Switch I region; other site 118163004941 G2 box; other site 118163004942 Switch II region; other site 118163004943 G3 box; other site 118163004944 G4 box; other site 118163004945 G5 box; other site 118163004946 KH domain; Region: KH_2; pfam07650 118163004947 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 118163004948 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 118163004949 active site 118163004950 Zn binding site [ion binding]; other site 118163004951 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 118163004952 metal ion-dependent adhesion site (MIDAS); other site 118163004953 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 118163004954 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 118163004955 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 118163004956 CHASE2 domain; Region: CHASE2; pfam05226 118163004957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163004958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163004959 metal binding site [ion binding]; metal-binding site 118163004960 active site 118163004961 I-site; other site 118163004962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163004963 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 118163004964 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 118163004965 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 118163004966 Family of unknown function (DUF490); Region: DUF490; pfam04357 118163004967 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 118163004968 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 118163004969 dimer interface [polypeptide binding]; other site 118163004970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163004971 catalytic residue [active] 118163004972 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 118163004973 putative dimer interface [polypeptide binding]; other site 118163004974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163004975 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 118163004976 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 118163004977 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 118163004978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163004979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 118163004980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163004981 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 118163004982 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 118163004983 Ligand binding site; other site 118163004984 Putative Catalytic site; other site 118163004985 DXD motif; other site 118163004986 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163004987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004988 binding surface 118163004989 TPR motif; other site 118163004990 TPR repeat; Region: TPR_11; pfam13414 118163004991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004992 binding surface 118163004993 TPR motif; other site 118163004994 TPR repeat; Region: TPR_11; pfam13414 118163004995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163004996 TPR motif; other site 118163004997 binding surface 118163004998 TPR repeat; Region: TPR_11; pfam13414 118163004999 HEAT repeats; Region: HEAT_2; pfam13646 118163005000 HEAT repeats; Region: HEAT_2; pfam13646 118163005001 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 118163005002 Penicillin amidase; Region: Penicil_amidase; pfam01804 118163005003 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 118163005004 active site 118163005005 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 118163005006 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163005007 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163005008 phosphopeptide binding site; other site 118163005009 Protease prsW family; Region: PrsW-protease; pfam13367 118163005010 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 118163005011 CoA binding domain; Region: CoA_binding_2; pfam13380 118163005012 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 118163005013 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 118163005014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 118163005015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 118163005016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163005017 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 118163005018 Probable transposase; Region: OrfB_IS605; pfam01385 118163005019 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163005020 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 118163005021 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 118163005022 Imelysin; Region: Peptidase_M75; pfam09375 118163005023 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 118163005024 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 118163005025 S-layer homology domain; Region: SLH; pfam00395 118163005026 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 118163005027 FeoA domain; Region: FeoA; pfam04023 118163005028 FeoA domain; Region: FeoA; pfam04023 118163005029 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163005030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 118163005031 Walker A/P-loop; other site 118163005032 ATP binding site [chemical binding]; other site 118163005033 Q-loop/lid; other site 118163005034 ABC transporter signature motif; other site 118163005035 Walker B; other site 118163005036 D-loop; other site 118163005037 H-loop/switch region; other site 118163005038 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 118163005039 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 118163005040 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 118163005041 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 118163005042 protein I interface; other site 118163005043 D2 interface; other site 118163005044 protein T interface; other site 118163005045 chlorophyll binding site; other site 118163005046 beta carotene binding site; other site 118163005047 pheophytin binding site; other site 118163005048 manganese-stabilizing polypeptide interface; other site 118163005049 CP43 interface; other site 118163005050 protein L interface; other site 118163005051 oxygen evolving complex binding site; other site 118163005052 bromide binding site; other site 118163005053 quinone binding site; other site 118163005054 Fe binding site [ion binding]; other site 118163005055 core light harvesting interface; other site 118163005056 cytochrome b559 alpha subunit interface; other site 118163005057 cytochrome c-550 interface; other site 118163005058 protein J interface; other site 118163005059 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 118163005060 active site 118163005061 Fe-S cluster binding site [ion binding]; other site 118163005062 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 118163005063 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 118163005064 thiamine phosphate binding site [chemical binding]; other site 118163005065 active site 118163005066 pyrophosphate binding site [ion binding]; other site 118163005067 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 118163005068 thiS-thiF/thiG interaction site; other site 118163005069 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 118163005070 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 118163005071 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 118163005072 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 118163005073 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 118163005074 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 118163005075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163005076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005077 active site 118163005078 phosphorylation site [posttranslational modification] 118163005079 intermolecular recognition site; other site 118163005080 dimerization interface [polypeptide binding]; other site 118163005081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163005082 DNA binding site [nucleotide binding] 118163005083 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163005084 putative binding surface; other site 118163005085 active site 118163005086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 118163005087 active site 118163005088 phosphorylation site [posttranslational modification] 118163005089 intermolecular recognition site; other site 118163005090 Response regulator receiver domain; Region: Response_reg; pfam00072 118163005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005092 active site 118163005093 phosphorylation site [posttranslational modification] 118163005094 intermolecular recognition site; other site 118163005095 dimerization interface [polypeptide binding]; other site 118163005096 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163005097 GAF domain; Region: GAF; pfam01590 118163005098 Phytochrome region; Region: PHY; pfam00360 118163005099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163005100 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 118163005101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005102 putative active site [active] 118163005103 heme pocket [chemical binding]; other site 118163005104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163005105 dimer interface [polypeptide binding]; other site 118163005106 phosphorylation site [posttranslational modification] 118163005107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163005108 ATP binding site [chemical binding]; other site 118163005109 Mg2+ binding site [ion binding]; other site 118163005110 G-X-G motif; other site 118163005111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005112 active site 118163005113 phosphorylation site [posttranslational modification] 118163005114 intermolecular recognition site; other site 118163005115 dimerization interface [polypeptide binding]; other site 118163005116 Protoglobin; Region: Protoglobin; pfam11563 118163005117 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 118163005118 diiron binding motif [ion binding]; other site 118163005119 Ferritin-like domain; Region: Ferritin; pfam00210 118163005120 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 118163005121 [2Fe-2S] cluster binding site [ion binding]; other site 118163005122 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163005123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005124 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005125 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 118163005126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163005127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163005128 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005130 active site 118163005131 phosphorylation site [posttranslational modification] 118163005132 dimerization interface [polypeptide binding]; other site 118163005133 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 118163005134 protein I interface; other site 118163005135 D2 interface; other site 118163005136 protein T interface; other site 118163005137 chlorophyll binding site; other site 118163005138 beta carotene binding site; other site 118163005139 pheophytin binding site; other site 118163005140 manganese-stabilizing polypeptide interface; other site 118163005141 CP43 interface; other site 118163005142 protein L interface; other site 118163005143 oxygen evolving complex binding site; other site 118163005144 bromide binding site; other site 118163005145 quinone binding site; other site 118163005146 Fe binding site [ion binding]; other site 118163005147 core light harvesting interface; other site 118163005148 cytochrome b559 alpha subunit interface; other site 118163005149 cytochrome c-550 interface; other site 118163005150 protein J interface; other site 118163005151 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 118163005152 pheophytin binding site; other site 118163005153 chlorophyll binding site; other site 118163005154 quinone binding site; other site 118163005155 Fe binding site [ion binding]; other site 118163005156 Photosystem II protein; Region: PSII; cl08223 118163005157 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 118163005158 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 118163005159 pheophytin binding site; other site 118163005160 chlorophyll binding site; other site 118163005161 quinone binding site; other site 118163005162 Fe binding site [ion binding]; other site 118163005163 photosystem II 47 kDa protein; Region: psbB; CHL00062 118163005164 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 118163005165 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005166 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005167 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005168 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005169 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005170 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163005171 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163005172 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005173 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 118163005174 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 118163005175 substrate binding site [chemical binding]; other site 118163005176 Uncharacterized conserved protein [Function unknown]; Region: COG4279 118163005177 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 118163005178 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 118163005179 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 118163005180 Malic enzyme, N-terminal domain; Region: malic; pfam00390 118163005181 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 118163005182 putative NAD(P) binding site [chemical binding]; other site 118163005183 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 118163005184 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 118163005185 putative rRNA binding site [nucleotide binding]; other site 118163005186 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 118163005187 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 118163005188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163005189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163005190 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 118163005191 catalytic residues [active] 118163005192 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163005193 putative active site [active] 118163005194 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 118163005195 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 118163005196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163005197 binding surface 118163005198 TPR motif; other site 118163005199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163005200 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 118163005201 Amidase; Region: Amidase; pfam01425 118163005202 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 118163005203 homodecamer interface [polypeptide binding]; other site 118163005204 GTP cyclohydrolase I; Provisional; Region: PLN03044 118163005205 active site 118163005206 putative catalytic site residues [active] 118163005207 zinc binding site [ion binding]; other site 118163005208 GTP-CH-I/GFRP interaction surface; other site 118163005209 short chain dehydrogenase; Provisional; Region: PRK07454 118163005210 classical (c) SDRs; Region: SDR_c; cd05233 118163005211 NAD(P) binding site [chemical binding]; other site 118163005212 active site 118163005213 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 118163005214 Protein of unknown function (DUF790); Region: DUF790; pfam05626 118163005215 Response regulator receiver domain; Region: Response_reg; pfam00072 118163005216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005217 active site 118163005218 phosphorylation site [posttranslational modification] 118163005219 intermolecular recognition site; other site 118163005220 dimerization interface [polypeptide binding]; other site 118163005221 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 118163005222 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 118163005223 heat shock protein 90; Provisional; Region: PRK05218 118163005224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163005225 ATP binding site [chemical binding]; other site 118163005226 Mg2+ binding site [ion binding]; other site 118163005227 G-X-G motif; other site 118163005228 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 118163005229 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 118163005230 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163005231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163005232 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 118163005233 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 118163005234 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 118163005235 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 118163005236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163005237 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163005238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163005239 Walker A/P-loop; other site 118163005240 ATP binding site [chemical binding]; other site 118163005241 Q-loop/lid; other site 118163005242 ABC transporter signature motif; other site 118163005243 Walker B; other site 118163005244 D-loop; other site 118163005245 H-loop/switch region; other site 118163005246 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 118163005247 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 118163005248 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 118163005249 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 118163005250 Response regulator receiver domain; Region: Response_reg; pfam00072 118163005251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005252 active site 118163005253 phosphorylation site [posttranslational modification] 118163005254 intermolecular recognition site; other site 118163005255 dimerization interface [polypeptide binding]; other site 118163005256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163005257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005258 active site 118163005259 phosphorylation site [posttranslational modification] 118163005260 intermolecular recognition site; other site 118163005261 dimerization interface [polypeptide binding]; other site 118163005262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163005263 DNA binding site [nucleotide binding] 118163005264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163005265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163005266 dimerization interface [polypeptide binding]; other site 118163005267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163005268 dimer interface [polypeptide binding]; other site 118163005269 phosphorylation site [posttranslational modification] 118163005270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163005271 ATP binding site [chemical binding]; other site 118163005272 Mg2+ binding site [ion binding]; other site 118163005273 G-X-G motif; other site 118163005274 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163005275 RNA methyltransferase, RsmE family; Region: TIGR00046 118163005276 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 118163005277 malate dehydrogenase; Reviewed; Region: PRK06223 118163005278 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 118163005279 NAD(P) binding site [chemical binding]; other site 118163005280 dimer interface [polypeptide binding]; other site 118163005281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 118163005282 substrate binding site [chemical binding]; other site 118163005283 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 118163005284 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 118163005285 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 118163005286 Zn binding site [ion binding]; other site 118163005287 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 118163005288 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 118163005289 UbiA prenyltransferase family; Region: UbiA; pfam01040 118163005290 CpeS-like protein; Region: CpeS; pfam09367 118163005291 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005292 Phycobilisome protein; Region: Phycobilisome; cl08227 118163005293 HEAT repeats; Region: HEAT_2; pfam13646 118163005294 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 118163005295 protein binding surface [polypeptide binding]; other site 118163005296 HEAT repeats; Region: HEAT_2; pfam13646 118163005297 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 118163005298 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 118163005299 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 118163005300 active site 118163005301 ATP binding site [chemical binding]; other site 118163005302 substrate binding site [chemical binding]; other site 118163005303 activation loop (A-loop); other site 118163005304 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 118163005305 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 118163005306 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 118163005307 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 118163005308 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 118163005309 active site 118163005310 SAM binding site [chemical binding]; other site 118163005311 homodimer interface [polypeptide binding]; other site 118163005312 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 118163005313 PhoH-like protein; Region: PhoH; pfam02562 118163005314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 118163005315 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 118163005316 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 118163005317 active site 118163005318 trimer interface [polypeptide binding]; other site 118163005319 allosteric site; other site 118163005320 active site lid [active] 118163005321 hexamer (dimer of trimers) interface [polypeptide binding]; other site 118163005322 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 118163005323 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 118163005324 cobalamin binding residues [chemical binding]; other site 118163005325 putative BtuC binding residues; other site 118163005326 dimer interface [polypeptide binding]; other site 118163005327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163005328 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 118163005329 putative ADP-binding pocket [chemical binding]; other site 118163005330 TPR repeat; Region: TPR_11; pfam13414 118163005331 Tetratricopeptide repeat; Region: TPR_1; pfam00515 118163005332 HEAT repeats; Region: HEAT_2; pfam13646 118163005333 non-SMC mitotic condensation complex subunit 1; Region: Cnd1; pfam12717 118163005334 L-aspartate oxidase; Provisional; Region: PRK07395 118163005335 L-aspartate oxidase; Provisional; Region: PRK06175 118163005336 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 118163005337 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 118163005338 catalytic residue [active] 118163005339 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 118163005340 active site 118163005341 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 118163005342 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 118163005343 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 118163005344 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 118163005345 minor groove reading motif; other site 118163005346 helix-hairpin-helix signature motif; other site 118163005347 substrate binding pocket [chemical binding]; other site 118163005348 active site 118163005349 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 118163005350 ribosomal protein S14; Region: rps14; CHL00074 118163005351 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 118163005352 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 118163005353 Right handed beta helix region; Region: Beta_helix; pfam13229 118163005354 Disaggregatase related; Region: Disaggr_assoc; pfam08480 118163005355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005356 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163005357 putative active site [active] 118163005358 heme pocket [chemical binding]; other site 118163005359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005360 putative active site [active] 118163005361 heme pocket [chemical binding]; other site 118163005362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005363 PAS fold; Region: PAS_3; pfam08447 118163005364 putative active site [active] 118163005365 heme pocket [chemical binding]; other site 118163005366 PAS domain S-box; Region: sensory_box; TIGR00229 118163005367 PAS domain S-box; Region: sensory_box; TIGR00229 118163005368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005369 putative active site [active] 118163005370 PAS domain S-box; Region: sensory_box; TIGR00229 118163005371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005372 putative active site [active] 118163005373 heme pocket [chemical binding]; other site 118163005374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005375 PAS fold; Region: PAS_3; pfam08447 118163005376 putative active site [active] 118163005377 heme pocket [chemical binding]; other site 118163005378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163005379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163005380 metal binding site [ion binding]; metal-binding site 118163005381 active site 118163005382 I-site; other site 118163005383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163005384 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 118163005385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163005386 S-adenosylmethionine binding site [chemical binding]; other site 118163005387 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 118163005388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 118163005389 ATP binding site [chemical binding]; other site 118163005390 Mg2+ binding site [ion binding]; other site 118163005391 G-X-G motif; other site 118163005392 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 118163005393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163005394 Coenzyme A binding pocket [chemical binding]; other site 118163005395 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 118163005396 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 118163005397 short chain dehydrogenase; Provisional; Region: PRK05693 118163005398 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 118163005399 NADP binding site [chemical binding]; other site 118163005400 active site 118163005401 steroid binding site; other site 118163005402 adenylosuccinate lyase; Provisional; Region: PRK07380 118163005403 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 118163005404 tetramer interface [polypeptide binding]; other site 118163005405 active site 118163005406 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 118163005407 Double zinc ribbon; Region: DZR; pfam12773 118163005408 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 118163005409 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 118163005410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163005411 Coenzyme A binding pocket [chemical binding]; other site 118163005412 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163005413 Ligand Binding Site [chemical binding]; other site 118163005414 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 118163005415 ATP-sulfurylase; Region: ATPS; cd00517 118163005416 active site 118163005417 HXXH motif; other site 118163005418 flexible loop; other site 118163005419 Caspase domain; Region: Peptidase_C14; pfam00656 118163005420 phosphoenolpyruvate synthase; Validated; Region: PRK06464 118163005421 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 118163005422 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 118163005423 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 118163005424 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 118163005425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163005426 NAD(P) binding site [chemical binding]; other site 118163005427 active site 118163005428 Predicted permeases [General function prediction only]; Region: COG0795 118163005429 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 118163005430 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 118163005431 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 118163005432 dimer interface [polypeptide binding]; other site 118163005433 putative functional site; other site 118163005434 putative MPT binding site; other site 118163005435 The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; Region: THUMP; smart00981 118163005436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163005437 S-adenosylmethionine binding site [chemical binding]; other site 118163005438 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 118163005439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163005440 Alkaline phosphatase homologues; Region: alkPPc; smart00098 118163005441 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 118163005442 active site 118163005443 dimer interface [polypeptide binding]; other site 118163005444 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 118163005445 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 118163005446 putative active site [active] 118163005447 catalytic site [active] 118163005448 putative metal binding site [ion binding]; other site 118163005449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 118163005450 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 118163005451 generic binding surface II; other site 118163005452 generic binding surface I; other site 118163005453 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 118163005454 putative active site [active] 118163005455 putative catalytic site [active] 118163005456 putative Mg binding site IVb [ion binding]; other site 118163005457 putative phosphate binding site [ion binding]; other site 118163005458 putative DNA binding site [nucleotide binding]; other site 118163005459 putative Mg binding site IVa [ion binding]; other site 118163005460 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 118163005461 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 118163005462 putative active site [active] 118163005463 putative metal binding site [ion binding]; other site 118163005464 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 118163005465 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 118163005466 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 118163005467 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 118163005468 dimerization interface [polypeptide binding]; other site 118163005469 DPS ferroxidase diiron center [ion binding]; other site 118163005470 ion pore; other site 118163005471 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 118163005472 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 118163005473 Cysteine-rich domain; Region: CCG; pfam02754 118163005474 Cysteine-rich domain; Region: CCG; pfam02754 118163005475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 118163005476 FAD binding domain; Region: FAD_binding_4; pfam01565 118163005477 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 118163005478 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 118163005479 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 118163005480 beta-phosphoglucomutase; Region: bPGM; TIGR01990 118163005481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163005482 motif II; other site 118163005483 sucrose synthase; Region: sucr_synth; TIGR02470 118163005484 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 118163005485 putative ADP-binding pocket [chemical binding]; other site 118163005486 phosphoenolpyruvate synthase; Validated; Region: PRK06464 118163005487 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 118163005488 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 118163005489 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 118163005490 FOG: CBS domain [General function prediction only]; Region: COG0517 118163005491 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 118163005492 CP12 domain; Region: CP12; pfam02672 118163005493 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 118163005494 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 118163005495 dimer interface [polypeptide binding]; other site 118163005496 PYR/PP interface [polypeptide binding]; other site 118163005497 TPP binding site [chemical binding]; other site 118163005498 substrate binding site [chemical binding]; other site 118163005499 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 118163005500 Domain of unknown function; Region: EKR; pfam10371 118163005501 4Fe-4S binding domain; Region: Fer4_6; pfam12837 118163005502 4Fe-4S binding domain; Region: Fer4; pfam00037 118163005503 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 118163005504 TPP-binding site [chemical binding]; other site 118163005505 dimer interface [polypeptide binding]; other site 118163005506 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 118163005507 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 118163005508 putative active site [active] 118163005509 putative FMN binding site [chemical binding]; other site 118163005510 putative substrate binding site [chemical binding]; other site 118163005511 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 118163005512 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 118163005513 active site 118163005514 ADP/pyrophosphate binding site [chemical binding]; other site 118163005515 dimerization interface [polypeptide binding]; other site 118163005516 allosteric effector site; other site 118163005517 fructose-1,6-bisphosphate binding site; other site 118163005518 polyphosphate kinase; Provisional; Region: PRK05443 118163005519 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 118163005520 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 118163005521 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 118163005522 putative domain interface [polypeptide binding]; other site 118163005523 putative active site [active] 118163005524 catalytic site [active] 118163005525 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 118163005526 putative domain interface [polypeptide binding]; other site 118163005527 putative active site [active] 118163005528 catalytic site [active] 118163005529 FOG: CBS domain [General function prediction only]; Region: COG0517 118163005530 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 118163005531 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 118163005532 hypothetical protein; Provisional; Region: PRK04194 118163005533 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 118163005534 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 118163005535 hinge; other site 118163005536 active site 118163005537 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 118163005538 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 118163005539 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 118163005540 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 118163005541 FAD binding site [chemical binding]; other site 118163005542 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 118163005543 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 118163005544 active site 118163005545 HIGH motif; other site 118163005546 dimer interface [polypeptide binding]; other site 118163005547 KMSKS motif; other site 118163005548 O-succinylbenzoate synthase; Provisional; Region: PRK02714 118163005549 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 118163005550 active site 118163005551 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 118163005552 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 118163005553 acyl-activating enzyme (AAE) consensus motif; other site 118163005554 putative AMP binding site [chemical binding]; other site 118163005555 putative active site [active] 118163005556 putative CoA binding site [chemical binding]; other site 118163005557 TPR repeat; Region: TPR_11; pfam13414 118163005558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163005559 binding surface 118163005560 TPR motif; other site 118163005561 TPR repeat; Region: TPR_11; pfam13414 118163005562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163005563 binding surface 118163005564 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163005565 TPR motif; other site 118163005566 TPR repeat; Region: TPR_11; pfam13414 118163005567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163005568 binding surface 118163005569 TPR motif; other site 118163005570 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 118163005571 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 118163005572 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 118163005573 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 118163005574 NADP binding site [chemical binding]; other site 118163005575 active site 118163005576 putative substrate binding site [chemical binding]; other site 118163005577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163005578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163005579 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 118163005580 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 118163005581 substrate binding site; other site 118163005582 metal-binding site 118163005583 Oligomer interface; other site 118163005584 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 118163005585 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 118163005586 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163005587 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 118163005588 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 118163005589 NAD binding site [chemical binding]; other site 118163005590 substrate binding site [chemical binding]; other site 118163005591 homodimer interface [polypeptide binding]; other site 118163005592 active site 118163005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163005594 S-adenosylmethionine binding site [chemical binding]; other site 118163005595 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 118163005596 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 118163005597 putative NAD(P) binding site [chemical binding]; other site 118163005598 active site 118163005599 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 118163005600 homotrimer interaction site [polypeptide binding]; other site 118163005601 zinc binding site [ion binding]; other site 118163005602 CDP-binding sites; other site 118163005603 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 118163005604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 118163005605 Putative phosphatase (DUF442); Region: DUF442; cl17385 118163005606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163005607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163005608 active site 118163005609 ATP binding site [chemical binding]; other site 118163005610 substrate binding site [chemical binding]; other site 118163005611 activation loop (A-loop); other site 118163005612 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 118163005613 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 118163005614 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163005615 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163005616 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 118163005617 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 118163005618 Uncharacterized conserved protein [Function unknown]; Region: COG0432 118163005619 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 118163005620 homotrimer interaction site [polypeptide binding]; other site 118163005621 putative active site [active] 118163005622 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 118163005623 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 118163005624 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 118163005625 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 118163005626 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 118163005627 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 118163005628 Protein of unknown function, DUF393; Region: DUF393; pfam04134 118163005629 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 118163005630 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 118163005631 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 118163005632 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 118163005633 RNA binding site [nucleotide binding]; other site 118163005634 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 118163005635 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 118163005636 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 118163005637 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 118163005638 active site 118163005639 ADP/pyrophosphate binding site [chemical binding]; other site 118163005640 dimerization interface [polypeptide binding]; other site 118163005641 allosteric effector site; other site 118163005642 fructose-1,6-bisphosphate binding site; other site 118163005643 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 118163005644 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 118163005645 dimerization interface [polypeptide binding]; other site 118163005646 ATP binding site [chemical binding]; other site 118163005647 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 118163005648 dimerization interface [polypeptide binding]; other site 118163005649 ATP binding site [chemical binding]; other site 118163005650 amidophosphoribosyltransferase; Provisional; Region: PRK07349 118163005651 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 118163005652 active site 118163005653 tetramer interface [polypeptide binding]; other site 118163005654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163005655 active site 118163005656 Protein of unknown function (DUF760); Region: DUF760; pfam05542 118163005657 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 118163005658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163005659 FeS/SAM binding site; other site 118163005660 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 118163005661 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 118163005662 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163005663 putative active site [active] 118163005664 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 118163005665 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 118163005666 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 118163005667 ThiS interaction site; other site 118163005668 putative active site [active] 118163005669 tetramer interface [polypeptide binding]; other site 118163005670 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 118163005671 Integral membrane protein TerC family; Region: TerC; cl10468 118163005672 TPR repeat; Region: TPR_11; pfam13414 118163005673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163005674 binding surface 118163005675 TPR motif; other site 118163005676 TPR repeat; Region: TPR_11; pfam13414 118163005677 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 118163005678 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 118163005679 putative C-terminal domain interface [polypeptide binding]; other site 118163005680 putative GSH binding site (G-site) [chemical binding]; other site 118163005681 putative dimer interface [polypeptide binding]; other site 118163005682 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 118163005683 N-terminal domain interface [polypeptide binding]; other site 118163005684 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 118163005685 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 118163005686 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 118163005687 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 118163005688 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 118163005689 active site 118163005690 Substrate binding site; other site 118163005691 Mg++ binding site; other site 118163005692 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 118163005693 putative trimer interface [polypeptide binding]; other site 118163005694 putative CoA binding site [chemical binding]; other site 118163005695 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 118163005696 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 118163005697 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 118163005698 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 118163005699 dimer interface [polypeptide binding]; other site 118163005700 ssDNA binding site [nucleotide binding]; other site 118163005701 tetramer (dimer of dimers) interface [polypeptide binding]; other site 118163005702 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 118163005703 metal ion-dependent adhesion site (MIDAS); other site 118163005704 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 118163005705 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 118163005706 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 118163005707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163005708 Walker A/P-loop; other site 118163005709 ATP binding site [chemical binding]; other site 118163005710 Q-loop/lid; other site 118163005711 ABC transporter signature motif; other site 118163005712 Walker B; other site 118163005713 D-loop; other site 118163005714 H-loop/switch region; other site 118163005715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 118163005716 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 118163005717 hypothetical protein; Validated; Region: PRK00110 118163005718 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 118163005719 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 118163005720 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 118163005721 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163005722 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 118163005723 nucleoside/Zn binding site; other site 118163005724 dimer interface [polypeptide binding]; other site 118163005725 catalytic motif [active] 118163005726 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 118163005727 seryl-tRNA synthetase; Provisional; Region: PRK05431 118163005728 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 118163005729 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 118163005730 dimer interface [polypeptide binding]; other site 118163005731 active site 118163005732 motif 1; other site 118163005733 motif 2; other site 118163005734 motif 3; other site 118163005735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163005736 dimer interface [polypeptide binding]; other site 118163005737 phosphorylation site [posttranslational modification] 118163005738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163005739 ATP binding site [chemical binding]; other site 118163005740 Mg2+ binding site [ion binding]; other site 118163005741 G-X-G motif; other site 118163005742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163005743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005744 active site 118163005745 phosphorylation site [posttranslational modification] 118163005746 intermolecular recognition site; other site 118163005747 dimerization interface [polypeptide binding]; other site 118163005748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163005749 DNA binding site [nucleotide binding] 118163005750 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 118163005751 active site 118163005752 SAM binding site [chemical binding]; other site 118163005753 homodimer interface [polypeptide binding]; other site 118163005754 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 118163005755 MgtE intracellular N domain; Region: MgtE_N; smart00924 118163005756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 118163005757 Divalent cation transporter; Region: MgtE; pfam01769 118163005758 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163005759 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163005760 structural tetrad; other site 118163005761 MEKHLA domain; Region: MEKHLA; pfam08670 118163005762 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 118163005763 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 118163005764 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 118163005765 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 118163005766 Walker A/P-loop; other site 118163005767 ATP binding site [chemical binding]; other site 118163005768 Q-loop/lid; other site 118163005769 ABC transporter signature motif; other site 118163005770 Walker B; other site 118163005771 D-loop; other site 118163005772 H-loop/switch region; other site 118163005773 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 118163005774 putative carbohydrate binding site [chemical binding]; other site 118163005775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 118163005776 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163005777 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 118163005778 Sulfatase; Region: Sulfatase; pfam00884 118163005779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 118163005780 Methyltransferase domain; Region: Methyltransf_24; pfam13578 118163005781 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163005782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163005783 active site 118163005784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163005785 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 118163005786 TM2 domain; Region: TM2; pfam05154 118163005787 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 118163005788 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 118163005789 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 118163005790 amidase; Provisional; Region: PRK09201 118163005791 Amidase; Region: Amidase; cl11426 118163005792 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 118163005793 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 118163005794 active site 118163005795 catalytic site [active] 118163005796 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 118163005797 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 118163005798 putative active site [active] 118163005799 PhoH-like protein; Region: PhoH; pfam02562 118163005800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163005801 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 118163005802 active site 118163005803 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 118163005804 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 118163005805 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 118163005806 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 118163005807 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 118163005808 Enoylreductase; Region: PKS_ER; smart00829 118163005809 NAD(P) binding site [chemical binding]; other site 118163005810 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 118163005811 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 118163005812 putative NADP binding site [chemical binding]; other site 118163005813 active site 118163005814 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163005815 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 118163005816 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 118163005817 substrate-cofactor binding pocket; other site 118163005818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163005819 catalytic residue [active] 118163005820 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163005821 Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152 118163005822 pheophytin binding site; other site 118163005823 chlorophyll binding site; other site 118163005824 quinone binding site; other site 118163005825 Fe binding site [ion binding]; other site 118163005826 photosystem II 44 kDa protein; Region: psbC; CHL00035 118163005827 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 118163005828 Response regulator receiver domain; Region: Response_reg; pfam00072 118163005829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005830 active site 118163005831 phosphorylation site [posttranslational modification] 118163005832 intermolecular recognition site; other site 118163005833 dimerization interface [polypeptide binding]; other site 118163005834 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 118163005835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 118163005836 inhibitor-cofactor binding pocket; inhibition site 118163005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163005838 catalytic residue [active] 118163005839 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 118163005840 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 118163005841 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 118163005842 homodimer interface [polypeptide binding]; other site 118163005843 NADP binding site [chemical binding]; other site 118163005844 substrate binding site [chemical binding]; other site 118163005845 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 118163005846 nudix motif; other site 118163005847 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 118163005848 C-terminal peptidase (prc); Region: prc; TIGR00225 118163005849 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 118163005850 protein binding site [polypeptide binding]; other site 118163005851 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 118163005852 Catalytic dyad [active] 118163005853 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 118163005854 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 118163005855 active site 118163005856 catalytic triad [active] 118163005857 oxyanion hole [active] 118163005858 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 118163005859 Exoribonuclease R [Transcription]; Region: VacB; COG0557 118163005860 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 118163005861 RNB domain; Region: RNB; pfam00773 118163005862 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 118163005863 RNA binding site [nucleotide binding]; other site 118163005864 Clp protease; Region: CLP_protease; pfam00574 118163005865 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 118163005866 oligomer interface [polypeptide binding]; other site 118163005867 active site residues [active] 118163005868 cell division protein; Validated; Region: ftsH; CHL00176 118163005869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163005870 Walker A motif; other site 118163005871 ATP binding site [chemical binding]; other site 118163005872 Walker B motif; other site 118163005873 arginine finger; other site 118163005874 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163005875 Response regulator receiver domain; Region: Response_reg; pfam00072 118163005876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163005877 active site 118163005878 phosphorylation site [posttranslational modification] 118163005879 intermolecular recognition site; other site 118163005880 dimerization interface [polypeptide binding]; other site 118163005881 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 118163005882 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 118163005883 metal binding site 2 [ion binding]; metal-binding site 118163005884 putative DNA binding helix; other site 118163005885 metal binding site 1 [ion binding]; metal-binding site 118163005886 dimer interface [polypeptide binding]; other site 118163005887 structural Zn2+ binding site [ion binding]; other site 118163005888 S-adenosylmethionine synthetase; Validated; Region: PRK05250 118163005889 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 118163005890 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 118163005891 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 118163005892 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 118163005893 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 118163005894 C-terminal domain interface [polypeptide binding]; other site 118163005895 GSH binding site (G-site) [chemical binding]; other site 118163005896 dimer interface [polypeptide binding]; other site 118163005897 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 118163005898 N-terminal domain interface [polypeptide binding]; other site 118163005899 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005900 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163005901 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005902 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163005903 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005904 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163005905 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005906 DNA polymerase III subunit delta; Validated; Region: PRK07452 118163005907 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 118163005908 Uncharacterized conserved protein [Function unknown]; Region: COG1262 118163005909 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 118163005910 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 118163005911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 118163005912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163005913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163005914 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 118163005915 proposed catalytic triad [active] 118163005916 active site nucleophile [active] 118163005917 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 118163005918 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163005919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163005920 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163005921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163005922 PAS domain; Region: PAS_9; pfam13426 118163005923 putative active site [active] 118163005924 heme pocket [chemical binding]; other site 118163005925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163005926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163005927 metal binding site [ion binding]; metal-binding site 118163005928 active site 118163005929 I-site; other site 118163005930 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163005931 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 118163005932 elongation factor G; Reviewed; Region: PRK12740 118163005933 G1 box; other site 118163005934 putative GEF interaction site [polypeptide binding]; other site 118163005935 GTP/Mg2+ binding site [chemical binding]; other site 118163005936 Switch I region; other site 118163005937 G2 box; other site 118163005938 G3 box; other site 118163005939 Switch II region; other site 118163005940 G4 box; other site 118163005941 G5 box; other site 118163005942 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 118163005943 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 118163005944 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 118163005945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163005946 Bacterial Ig-like domain; Region: Big_5; pfam13205 118163005947 Anti-sigma-K factor rskA; Region: RskA; pfam10099 118163005948 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 118163005949 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 118163005950 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 118163005951 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 118163005952 dephospho-CoA kinase; Region: TIGR00152 118163005953 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 118163005954 CoA-binding site [chemical binding]; other site 118163005955 ATP-binding [chemical binding]; other site 118163005956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163005958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005959 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163005960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 118163005961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 118163005962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 118163005963 dimerization interface [polypeptide binding]; other site 118163005964 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 118163005965 active site 118163005966 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 118163005967 active site 118163005968 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 118163005969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163005970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163005971 DNA binding residues [nucleotide binding] 118163005972 dimerization interface [polypeptide binding]; other site 118163005973 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163005974 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163005975 protein binding site [polypeptide binding]; other site 118163005976 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163005977 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163005978 protein binding site [polypeptide binding]; other site 118163005979 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 118163005980 PemK-like protein; Region: PemK; pfam02452 118163005981 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 118163005982 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163005983 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 118163005984 metal-binding site 118163005985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163005986 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163005987 YcfA-like protein; Region: YcfA; pfam07927 118163005988 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 118163005989 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 118163005990 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 118163005991 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163005992 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163005993 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 118163005994 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 118163005995 dimerization interface [polypeptide binding]; other site 118163005996 domain crossover interface; other site 118163005997 redox-dependent activation switch; other site 118163005998 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 118163005999 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 118163006000 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 118163006001 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 118163006002 active site 118163006003 Probable transposase; Region: OrfB_IS605; pfam01385 118163006004 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163006005 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 118163006006 Predicted membrane protein [Function unknown]; Region: COG2324 118163006007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 118163006008 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 118163006009 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 118163006010 phosphatidate cytidylyltransferase; Region: PLN02953 118163006011 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 118163006012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163006013 S-adenosylmethionine binding site [chemical binding]; other site 118163006014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163006015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006016 active site 118163006017 phosphorylation site [posttranslational modification] 118163006018 intermolecular recognition site; other site 118163006019 dimerization interface [polypeptide binding]; other site 118163006020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163006021 DNA binding site [nucleotide binding] 118163006022 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163006023 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 118163006024 Protein export membrane protein; Region: SecD_SecF; cl14618 118163006025 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163006026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163006027 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163006028 GUN4-like; Region: GUN4; pfam05419 118163006029 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 118163006030 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 118163006031 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 118163006032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 118163006033 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 118163006034 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 118163006035 MoaE homodimer interface [polypeptide binding]; other site 118163006036 MoaD interaction [polypeptide binding]; other site 118163006037 active site residues [active] 118163006038 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163006039 Phycobilisome protein; Region: Phycobilisome; cl08227 118163006040 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 118163006041 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163006042 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163006043 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163006044 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163006045 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163006046 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163006047 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163006048 HEAT repeats; Region: HEAT_2; pfam13646 118163006049 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 118163006050 HEAT repeats; Region: HEAT_2; pfam13646 118163006051 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 118163006052 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 118163006053 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 118163006054 PYR/PP interface [polypeptide binding]; other site 118163006055 dimer interface [polypeptide binding]; other site 118163006056 TPP binding site [chemical binding]; other site 118163006057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 118163006058 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 118163006059 TPP-binding site [chemical binding]; other site 118163006060 dimer interface [polypeptide binding]; other site 118163006061 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 118163006062 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 118163006063 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 118163006064 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 118163006065 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 118163006066 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 118163006067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163006068 FeS/SAM binding site; other site 118163006069 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 118163006070 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 118163006071 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 118163006072 active site 118163006073 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 118163006074 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 118163006075 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 118163006076 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 118163006077 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 118163006078 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 118163006079 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 118163006080 four helix bundle protein; Region: TIGR02436 118163006081 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 118163006082 WYL domain; Region: WYL; pfam13280 118163006083 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 118163006084 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 118163006085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163006086 S-adenosylmethionine binding site [chemical binding]; other site 118163006087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163006088 Probable transposase; Region: OrfB_IS605; pfam01385 118163006089 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163006090 Ligand Binding Site [chemical binding]; other site 118163006091 FtsH Extracellular; Region: FtsH_ext; pfam06480 118163006092 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 118163006093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163006094 Walker A motif; other site 118163006095 ATP binding site [chemical binding]; other site 118163006096 Walker B motif; other site 118163006097 arginine finger; other site 118163006098 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163006099 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 118163006100 isoleucyl-tRNA synthetase; Region: PLN02843 118163006101 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 118163006102 HIGH motif; other site 118163006103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 118163006104 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 118163006105 active site 118163006106 KMSKS motif; other site 118163006107 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 118163006108 tRNA binding surface [nucleotide binding]; other site 118163006109 anticodon binding site; other site 118163006110 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 118163006111 threonine dehydratase; Reviewed; Region: PRK09224 118163006112 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 118163006113 tetramer interface [polypeptide binding]; other site 118163006114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163006115 catalytic residue [active] 118163006116 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 118163006117 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 118163006118 putative Ile/Val binding site [chemical binding]; other site 118163006119 2-isopropylmalate synthase; Validated; Region: PRK00915 118163006120 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 118163006121 active site 118163006122 catalytic residues [active] 118163006123 metal binding site [ion binding]; metal-binding site 118163006124 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 118163006125 Uncharacterized conserved protein [Function unknown]; Region: COG1432 118163006126 LabA_like proteins; Region: LabA; cd10911 118163006127 putative metal binding site [ion binding]; other site 118163006128 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 118163006129 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 118163006130 active site residue [active] 118163006131 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 118163006132 active site residue [active] 118163006133 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 118163006134 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 118163006135 ATP binding site [chemical binding]; other site 118163006136 Mg2+ binding site [ion binding]; other site 118163006137 G-X-G motif; other site 118163006138 Response regulator receiver domain; Region: Response_reg; pfam00072 118163006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006140 active site 118163006141 phosphorylation site [posttranslational modification] 118163006142 intermolecular recognition site; other site 118163006143 dimerization interface [polypeptide binding]; other site 118163006144 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 118163006145 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 118163006146 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 118163006147 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 118163006148 anti sigma factor interaction site; other site 118163006149 regulatory phosphorylation site [posttranslational modification]; other site 118163006150 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 118163006151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163006152 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 118163006153 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163006154 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163006155 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 118163006156 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 118163006157 NAD binding site [chemical binding]; other site 118163006158 homodimer interface [polypeptide binding]; other site 118163006159 active site 118163006160 substrate binding site [chemical binding]; other site 118163006161 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 118163006162 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 118163006163 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 118163006164 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 118163006165 active site 118163006166 PHP Thumb interface [polypeptide binding]; other site 118163006167 metal binding site [ion binding]; metal-binding site 118163006168 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 118163006169 protein-splicing catalytic site; other site 118163006170 thioester formation/cholesterol transfer; other site 118163006171 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 118163006172 Aspartase; Region: Aspartase; cd01357 118163006173 active sites [active] 118163006174 tetramer interface [polypeptide binding]; other site 118163006175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163006176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163006177 dimer interface [polypeptide binding]; other site 118163006178 phosphorylation site [posttranslational modification] 118163006179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163006180 ATP binding site [chemical binding]; other site 118163006181 Mg2+ binding site [ion binding]; other site 118163006182 G-X-G motif; other site 118163006183 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 118163006184 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 118163006185 TMP-binding site; other site 118163006186 ATP-binding site [chemical binding]; other site 118163006187 mercuric reductase; Validated; Region: PRK06370 118163006188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163006189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 118163006190 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 118163006191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163006192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163006193 homodimer interface [polypeptide binding]; other site 118163006194 catalytic residue [active] 118163006195 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 118163006196 IHF dimer interface [polypeptide binding]; other site 118163006197 IHF - DNA interface [nucleotide binding]; other site 118163006198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163006199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163006200 DNA binding residues [nucleotide binding] 118163006201 dimerization interface [polypeptide binding]; other site 118163006202 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 118163006203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163006204 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 118163006205 catalytic site [active] 118163006206 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 118163006207 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 118163006208 Walker A/P-loop; other site 118163006209 ATP binding site [chemical binding]; other site 118163006210 Q-loop/lid; other site 118163006211 ABC transporter signature motif; other site 118163006212 Walker B; other site 118163006213 D-loop; other site 118163006214 H-loop/switch region; other site 118163006215 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 118163006216 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 118163006217 Walker A/P-loop; other site 118163006218 ATP binding site [chemical binding]; other site 118163006219 Q-loop/lid; other site 118163006220 ABC transporter signature motif; other site 118163006221 Walker B; other site 118163006222 D-loop; other site 118163006223 H-loop/switch region; other site 118163006224 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 118163006225 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 118163006226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 118163006227 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 118163006228 TM-ABC transporter signature motif; other site 118163006229 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 118163006230 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 118163006231 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 118163006232 TM-ABC transporter signature motif; other site 118163006233 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 118163006234 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 118163006235 putative ligand binding site [chemical binding]; other site 118163006236 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 118163006237 G1 box; other site 118163006238 GTP/Mg2+ binding site [chemical binding]; other site 118163006239 G2 box; other site 118163006240 Switch I region; other site 118163006241 G3 box; other site 118163006242 Switch II region; other site 118163006243 G4 box; other site 118163006244 G5 box; other site 118163006245 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 118163006246 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 118163006247 Mechanosensitive ion channel; Region: MS_channel; pfam00924 118163006248 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 118163006249 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 118163006250 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 118163006251 putative acyl-acceptor binding pocket; other site 118163006252 TMAO/DMSO reductase; Reviewed; Region: PRK05363 118163006253 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 118163006254 Moco binding site; other site 118163006255 metal coordination site [ion binding]; other site 118163006256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163006257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163006258 phosphopeptide binding site; other site 118163006259 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 118163006260 cyclase homology domain; Region: CHD; cd07302 118163006261 nucleotidyl binding site; other site 118163006262 metal binding site [ion binding]; metal-binding site 118163006263 dimer interface [polypeptide binding]; other site 118163006264 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 118163006265 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 118163006266 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163006267 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163006268 active site 118163006269 ATP binding site [chemical binding]; other site 118163006270 substrate binding site [chemical binding]; other site 118163006271 activation loop (A-loop); other site 118163006272 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 118163006273 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 118163006274 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 118163006275 Repair protein; Region: Repair_PSII; pfam04536 118163006276 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 118163006277 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 118163006278 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 118163006279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163006280 Walker A motif; other site 118163006281 ATP binding site [chemical binding]; other site 118163006282 Walker B motif; other site 118163006283 arginine finger; other site 118163006284 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 118163006286 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 118163006287 AAA domain; Region: AAA_33; pfam13671 118163006288 ATP-binding site [chemical binding]; other site 118163006289 Gluconate-6-phosphate binding site [chemical binding]; other site 118163006290 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 118163006291 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 118163006292 active site 118163006293 Zn binding site [ion binding]; other site 118163006294 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 118163006295 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 118163006296 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 118163006297 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 118163006298 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 118163006299 Walker A motif; other site 118163006300 ATP binding site [chemical binding]; other site 118163006301 Walker B motif; other site 118163006302 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 118163006303 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 118163006304 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 118163006305 Walker A motif; other site 118163006306 ATP binding site [chemical binding]; other site 118163006307 Walker B motif; other site 118163006308 heat shock protein GrpE; Provisional; Region: PRK14140 118163006309 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 118163006310 dimer interface [polypeptide binding]; other site 118163006311 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 118163006312 molecular chaperone DnaK; Provisional; Region: PRK13411 118163006313 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 118163006314 nucleotide binding site [chemical binding]; other site 118163006315 NEF interaction site [polypeptide binding]; other site 118163006316 SBD interface [polypeptide binding]; other site 118163006317 chaperone protein DnaJ; Provisional; Region: PRK14293 118163006318 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163006319 HSP70 interaction site [polypeptide binding]; other site 118163006320 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 118163006321 substrate binding site [polypeptide binding]; other site 118163006322 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 118163006323 Zn binding sites [ion binding]; other site 118163006324 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 118163006325 dimer interface [polypeptide binding]; other site 118163006326 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 118163006327 CPxP motif; other site 118163006328 GTPase RsgA; Reviewed; Region: PRK12289 118163006329 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 118163006330 RNA binding site [nucleotide binding]; other site 118163006331 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 118163006332 GTPase/Zn-binding domain interface [polypeptide binding]; other site 118163006333 GTP/Mg2+ binding site [chemical binding]; other site 118163006334 G4 box; other site 118163006335 G5 box; other site 118163006336 G1 box; other site 118163006337 Switch I region; other site 118163006338 G2 box; other site 118163006339 G3 box; other site 118163006340 Switch II region; other site 118163006341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163006342 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 118163006343 NAD(P) binding site [chemical binding]; other site 118163006344 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 118163006345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163006346 NADH(P)-binding; Region: NAD_binding_10; pfam13460 118163006347 active site 118163006348 TPR repeat; Region: TPR_11; pfam13414 118163006349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163006350 binding surface 118163006351 TPR motif; other site 118163006352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 118163006353 mercuric reductase; Validated; Region: PRK06370 118163006354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163006355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163006356 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 118163006357 Uncharacterized conserved protein [Function unknown]; Region: COG0398 118163006358 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 118163006359 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 118163006360 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 118163006361 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 118163006362 inhibitor-cofactor binding pocket; inhibition site 118163006363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163006364 catalytic residue [active] 118163006365 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006367 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163006368 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006369 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 118163006370 active site 118163006371 catalytic triad [active] 118163006372 oxyanion hole [active] 118163006373 Flavin Reductases; Region: FlaRed; cl00801 118163006374 hypothetical protein; Provisional; Region: PRK07338 118163006375 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 118163006376 metal binding site [ion binding]; metal-binding site 118163006377 dimer interface [polypeptide binding]; other site 118163006378 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 118163006379 diiron binding motif [ion binding]; other site 118163006380 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 118163006381 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 118163006382 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 118163006383 active site 118163006384 Riboflavin kinase; Region: Flavokinase; pfam01687 118163006385 MoxR-like ATPases [General function prediction only]; Region: COG0714 118163006386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163006387 Walker A motif; other site 118163006388 ATP binding site [chemical binding]; other site 118163006389 Walker B motif; other site 118163006390 arginine finger; other site 118163006391 Dihaem cytochrome c; Region: DHC; pfam09626 118163006392 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 118163006393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163006394 conserved gate region; other site 118163006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163006396 dimer interface [polypeptide binding]; other site 118163006397 ABC-ATPase subunit interface; other site 118163006398 putative PBP binding loops; other site 118163006399 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 118163006400 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 118163006401 substrate binding pocket [chemical binding]; other site 118163006402 membrane-bound complex binding site; other site 118163006403 hinge residues; other site 118163006404 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 118163006405 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 118163006406 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 118163006407 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 118163006408 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 118163006409 BT1 family; Region: BT1; pfam03092 118163006410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163006411 putative substrate translocation pore; other site 118163006412 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 118163006413 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 118163006414 Predicted transcriptional regulators [Transcription]; Region: COG1733 118163006415 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 118163006416 classical (c) SDRs; Region: SDR_c; cd05233 118163006417 NAD(P) binding site [chemical binding]; other site 118163006418 active site 118163006419 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 118163006420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163006421 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 118163006422 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 118163006423 motif 1; other site 118163006424 active site 118163006425 motif 2; other site 118163006426 motif 3; other site 118163006427 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 118163006428 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 118163006429 trimer interface [polypeptide binding]; other site 118163006430 dimer interface [polypeptide binding]; other site 118163006431 putative active site [active] 118163006432 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163006433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163006434 catalytic loop [active] 118163006435 iron binding site [ion binding]; other site 118163006436 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 118163006437 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 118163006438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163006439 S-adenosylmethionine binding site [chemical binding]; other site 118163006440 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 118163006441 allophycocyanin, beta subunit; Region: apcB; TIGR01337 118163006442 glutamine synthetase, type I; Region: GlnA; TIGR00653 118163006443 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 118163006444 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 118163006445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163006446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 118163006447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163006448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163006449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163006450 motif II; other site 118163006451 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163006452 Polyomavirus coat protein; Region: Polyoma_coat2; cl17644 118163006453 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 118163006454 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 118163006455 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 118163006456 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 118163006457 intersubunit interface [polypeptide binding]; other site 118163006458 active site 118163006459 Zn2+ binding site [ion binding]; other site 118163006460 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 118163006461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163006462 motif II; other site 118163006463 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163006464 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163006465 structural tetrad; other site 118163006466 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163006467 structural tetrad; other site 118163006468 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 118163006469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163006470 Walker A/P-loop; other site 118163006471 ATP binding site [chemical binding]; other site 118163006472 Q-loop/lid; other site 118163006473 ABC transporter signature motif; other site 118163006474 Walker B; other site 118163006475 D-loop; other site 118163006476 H-loop/switch region; other site 118163006477 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 118163006478 ABC-2 type transporter; Region: ABC2_membrane; cl17235 118163006479 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 118163006480 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 118163006481 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 118163006482 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163006483 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 118163006484 ligand binding site [chemical binding]; other site 118163006485 flexible hinge region; other site 118163006486 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 118163006487 putative switch regulator; other site 118163006488 non-specific DNA interactions [nucleotide binding]; other site 118163006489 DNA binding site [nucleotide binding] 118163006490 sequence specific DNA binding site [nucleotide binding]; other site 118163006491 putative cAMP binding site [chemical binding]; other site 118163006492 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 118163006493 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 118163006494 NAD binding site [chemical binding]; other site 118163006495 homotetramer interface [polypeptide binding]; other site 118163006496 homodimer interface [polypeptide binding]; other site 118163006497 substrate binding site [chemical binding]; other site 118163006498 active site 118163006499 Protein of unknown function (DUF98); Region: DUF98; pfam01947 118163006500 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 118163006501 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 118163006502 putative active site [active] 118163006503 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 118163006504 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 118163006505 tRNA; other site 118163006506 putative tRNA binding site [nucleotide binding]; other site 118163006507 putative NADP binding site [chemical binding]; other site 118163006508 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 118163006509 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163006510 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163006511 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 118163006512 Ligand Binding Site [chemical binding]; other site 118163006513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163006514 Ligand Binding Site [chemical binding]; other site 118163006515 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 118163006516 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 118163006517 Protein of unknown function (DUF512); Region: DUF512; pfam04459 118163006518 acetyl-CoA synthetase; Provisional; Region: PRK00174 118163006519 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 118163006520 active site 118163006521 CoA binding site [chemical binding]; other site 118163006522 acyl-activating enzyme (AAE) consensus motif; other site 118163006523 AMP binding site [chemical binding]; other site 118163006524 acetate binding site [chemical binding]; other site 118163006525 AAA ATPase domain; Region: AAA_16; pfam13191 118163006526 NACHT domain; Region: NACHT; pfam05729 118163006527 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 118163006528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006529 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163006530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006533 Protein of unknown function (DUF552); Region: DUF552; pfam04472 118163006534 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 118163006535 putative hydrophobic ligand binding site [chemical binding]; other site 118163006536 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 118163006537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163006538 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 118163006539 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 118163006540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163006541 FeS/SAM binding site; other site 118163006542 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 118163006543 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 118163006544 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 118163006545 GTP/Mg2+ binding site [chemical binding]; other site 118163006546 G4 box; other site 118163006547 G5 box; other site 118163006548 G1 box; other site 118163006549 Switch I region; other site 118163006550 G2 box; other site 118163006551 G3 box; other site 118163006552 Switch II region; other site 118163006553 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 118163006554 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 118163006555 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163006556 dimer interface [polypeptide binding]; other site 118163006557 [2Fe-2S] cluster binding site [ion binding]; other site 118163006558 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 118163006559 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 118163006560 dimerization interface [polypeptide binding]; other site 118163006561 DPS ferroxidase diiron center [ion binding]; other site 118163006562 ion pore; other site 118163006563 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 118163006564 substrate binding site [chemical binding]; other site 118163006565 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 118163006566 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 118163006567 putative binding surface; other site 118163006568 active site 118163006569 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 118163006570 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 118163006571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163006572 ATP binding site [chemical binding]; other site 118163006573 Mg2+ binding site [ion binding]; other site 118163006574 G-X-G motif; other site 118163006575 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 118163006576 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163006577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006578 active site 118163006579 phosphorylation site [posttranslational modification] 118163006580 intermolecular recognition site; other site 118163006581 dimerization interface [polypeptide binding]; other site 118163006582 HAMP domain; Region: HAMP; pfam00672 118163006583 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163006584 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163006585 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163006586 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163006587 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 118163006588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163006589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163006590 dimer interface [polypeptide binding]; other site 118163006591 putative CheW interface [polypeptide binding]; other site 118163006592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163006593 dimerization interface [polypeptide binding]; other site 118163006594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163006595 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163006596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163006597 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163006598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 118163006599 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 118163006600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 118163006601 dimer interface [polypeptide binding]; other site 118163006602 putative CheW interface [polypeptide binding]; other site 118163006603 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 118163006604 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 118163006605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006606 Response regulator receiver domain; Region: Response_reg; pfam00072 118163006607 active site 118163006608 phosphorylation site [posttranslational modification] 118163006609 intermolecular recognition site; other site 118163006610 dimerization interface [polypeptide binding]; other site 118163006611 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 118163006612 Response regulator receiver domain; Region: Response_reg; pfam00072 118163006613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006614 active site 118163006615 phosphorylation site [posttranslational modification] 118163006616 intermolecular recognition site; other site 118163006617 dimerization interface [polypeptide binding]; other site 118163006618 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 118163006619 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 118163006620 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 118163006621 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 118163006622 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 118163006623 substrate binding site [chemical binding]; other site 118163006624 ligand binding site [chemical binding]; other site 118163006625 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163006626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006627 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006628 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163006629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163006630 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163006631 metal binding site [ion binding]; metal-binding site 118163006632 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 118163006633 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163006634 Predicted membrane protein [Function unknown]; Region: COG2259 118163006635 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163006636 Protein export membrane protein; Region: SecD_SecF; cl14618 118163006637 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163006638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163006639 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163006640 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 118163006641 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 118163006642 Peptidase family M23; Region: Peptidase_M23; pfam01551 118163006643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 118163006644 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 118163006645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163006646 catalytic loop [active] 118163006647 iron binding site [ion binding]; other site 118163006648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163006649 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163006650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163006651 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 118163006652 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 118163006653 iron-sulfur cluster [ion binding]; other site 118163006654 [2Fe-2S] cluster binding site [ion binding]; other site 118163006655 Uncharacterized conserved protein [Function unknown]; Region: COG3349 118163006656 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 118163006657 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 118163006658 G1 box; other site 118163006659 GTP/Mg2+ binding site [chemical binding]; other site 118163006660 Switch I region; other site 118163006661 G2 box; other site 118163006662 Switch II region; other site 118163006663 G3 box; other site 118163006664 G4 box; other site 118163006665 G5 box; other site 118163006666 Domain of unknown function (DUF697); Region: DUF697; pfam05128 118163006667 homoserine dehydrogenase; Provisional; Region: PRK06349 118163006668 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 118163006669 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 118163006670 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 118163006671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 118163006672 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 118163006673 Peptidase family M23; Region: Peptidase_M23; pfam01551 118163006674 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 118163006675 catalytic triad [active] 118163006676 glucokinase; Provisional; Region: glk; PRK00292 118163006677 glucokinase, proteobacterial type; Region: glk; TIGR00749 118163006678 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 118163006679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163006680 Walker A/P-loop; other site 118163006681 ATP binding site [chemical binding]; other site 118163006682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163006683 ABC transporter signature motif; other site 118163006684 Walker B; other site 118163006685 D-loop; other site 118163006686 H-loop/switch region; other site 118163006687 Domain of unknown function DUF29; Region: DUF29; pfam01724 118163006688 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 118163006689 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 118163006690 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 118163006691 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 118163006692 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 118163006693 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 118163006694 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 118163006695 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163006696 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 118163006697 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 118163006698 tetramer (dimer of dimers) interface [polypeptide binding]; other site 118163006699 active site 118163006700 dimer interface [polypeptide binding]; other site 118163006701 gamma-glutamyl kinase; Provisional; Region: PRK05429 118163006702 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 118163006703 nucleotide binding site [chemical binding]; other site 118163006704 homotetrameric interface [polypeptide binding]; other site 118163006705 putative phosphate binding site [ion binding]; other site 118163006706 putative allosteric binding site; other site 118163006707 PUA domain; Region: PUA; pfam01472 118163006708 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 118163006709 pseudouridine synthase; Region: TIGR00093 118163006710 active site 118163006711 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 118163006712 homotrimer interface [polypeptide binding]; other site 118163006713 Walker A motif; other site 118163006714 GTP binding site [chemical binding]; other site 118163006715 Walker B motif; other site 118163006716 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 118163006717 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163006718 putative metal binding site; other site 118163006719 putative acyl transferase; Provisional; Region: PRK10502 118163006720 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 118163006721 putative trimer interface [polypeptide binding]; other site 118163006722 putative active site [active] 118163006723 putative substrate binding site [chemical binding]; other site 118163006724 putative CoA binding site [chemical binding]; other site 118163006725 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 118163006726 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163006727 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 118163006728 Probable Catalytic site; other site 118163006729 metal-binding site 118163006730 colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016 118163006731 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 118163006732 trimer interface [polypeptide binding]; other site 118163006733 active site 118163006734 substrate binding site [chemical binding]; other site 118163006735 CoA binding site [chemical binding]; other site 118163006736 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 118163006737 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163006738 TrkA-N domain; Region: TrkA_N; pfam02254 118163006739 argininosuccinate synthase; Provisional; Region: PRK13820 118163006740 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 118163006741 ANP binding site [chemical binding]; other site 118163006742 Substrate Binding Site II [chemical binding]; other site 118163006743 Substrate Binding Site I [chemical binding]; other site 118163006744 Protein of unknown function DUF99; Region: DUF99; pfam01949 118163006745 hypothetical protein; Provisional; Region: PRK00766 118163006746 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 118163006747 nudix motif; other site 118163006748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163006749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006750 active site 118163006751 phosphorylation site [posttranslational modification] 118163006752 intermolecular recognition site; other site 118163006753 dimerization interface [polypeptide binding]; other site 118163006754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163006755 DNA binding site [nucleotide binding] 118163006756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163006757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163006758 active site 118163006759 ATP binding site [chemical binding]; other site 118163006760 substrate binding site [chemical binding]; other site 118163006761 activation loop (A-loop); other site 118163006762 Bacterial SH3 domain; Region: SH3_3; cl17532 118163006763 Putative esterase; Region: Esterase; pfam00756 118163006764 Predicted integral membrane protein [Function unknown]; Region: COG0392 118163006765 Uncharacterized conserved protein [Function unknown]; Region: COG2898 118163006766 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 118163006767 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 118163006768 Putative esterase; Region: Esterase; pfam00756 118163006769 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 118163006770 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 118163006771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163006772 Probable transposase; Region: OrfB_IS605; pfam01385 118163006773 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163006774 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 118163006775 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163006776 Magnesium ion binding site [ion binding]; other site 118163006777 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163006778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163006779 active site 118163006780 Transcriptional regulator [Transcription]; Region: LytR; COG1316 118163006781 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 118163006782 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163006783 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163006784 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163006785 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163006786 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 118163006787 FtsX-like permease family; Region: FtsX; pfam02687 118163006788 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 118163006789 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163006790 FtsX-like permease family; Region: FtsX; pfam02687 118163006791 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163006792 putative active site [active] 118163006793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 118163006794 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163006795 Walker A/P-loop; other site 118163006796 ATP binding site [chemical binding]; other site 118163006797 Q-loop/lid; other site 118163006798 ABC transporter signature motif; other site 118163006799 Walker B; other site 118163006800 D-loop; other site 118163006801 H-loop/switch region; other site 118163006802 O-Antigen ligase; Region: Wzy_C; pfam04932 118163006803 calcium/proton exchanger (cax); Region: cax; TIGR00378 118163006804 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163006805 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163006806 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 118163006807 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 118163006808 transmembrane helices; other site 118163006809 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 118163006810 TrkA-C domain; Region: TrkA_C; pfam02080 118163006811 TrkA-C domain; Region: TrkA_C; pfam02080 118163006812 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 118163006813 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 118163006814 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 118163006815 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 118163006816 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 118163006817 putative dimer interface [polypeptide binding]; other site 118163006818 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 118163006819 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 118163006820 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 118163006821 tartrate dehydrogenase; Region: TTC; TIGR02089 118163006822 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 118163006823 substrate binding site [chemical binding]; other site 118163006824 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 118163006825 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 118163006826 substrate binding site [chemical binding]; other site 118163006827 ligand binding site [chemical binding]; other site 118163006828 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 118163006829 aromatic arch; other site 118163006830 DCoH dimer interaction site [polypeptide binding]; other site 118163006831 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 118163006832 DCoH tetramer interaction site [polypeptide binding]; other site 118163006833 substrate binding site [chemical binding]; other site 118163006834 urease subunit alpha; Reviewed; Region: ureC; PRK13207 118163006835 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 118163006836 subunit interactions [polypeptide binding]; other site 118163006837 active site 118163006838 flap region; other site 118163006839 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 118163006840 putative active site [active] 118163006841 putative metal binding residues [ion binding]; other site 118163006842 signature motif; other site 118163006843 putative dimer interface [polypeptide binding]; other site 118163006844 putative phosphate binding site [ion binding]; other site 118163006845 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 118163006846 active site 118163006847 Peptidase family M50; Region: Peptidase_M50; pfam02163 118163006848 putative substrate binding region [chemical binding]; other site 118163006849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 118163006850 Double zinc ribbon; Region: DZR; pfam12773 118163006851 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 118163006852 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163006853 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163006854 phosphopeptide binding site; other site 118163006855 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 118163006856 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 118163006857 putative active site [active] 118163006858 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 118163006859 Uncharacterized conserved protein [Function unknown]; Region: COG2928 118163006860 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 118163006861 putative RNA binding site [nucleotide binding]; other site 118163006862 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 118163006863 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 118163006864 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 118163006865 P loop; other site 118163006866 GTP binding site [chemical binding]; other site 118163006867 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 118163006868 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 118163006869 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163006870 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163006871 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163006872 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163006873 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163006874 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163006875 Response regulator receiver domain; Region: Response_reg; pfam00072 118163006876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006877 active site 118163006878 phosphorylation site [posttranslational modification] 118163006879 intermolecular recognition site; other site 118163006880 dimerization interface [polypeptide binding]; other site 118163006881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163006882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163006883 metal binding site [ion binding]; metal-binding site 118163006884 active site 118163006885 I-site; other site 118163006886 Cache domain; Region: Cache_1; pfam02743 118163006887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163006888 dimerization interface [polypeptide binding]; other site 118163006889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163006890 dimer interface [polypeptide binding]; other site 118163006891 phosphorylation site [posttranslational modification] 118163006892 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163006893 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163006894 phosphopeptide binding site; other site 118163006895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163006896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163006897 metal binding site [ion binding]; metal-binding site 118163006898 active site 118163006899 I-site; other site 118163006900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163006901 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163006902 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163006903 phosphopeptide binding site; other site 118163006904 PAS domain S-box; Region: sensory_box; TIGR00229 118163006905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163006906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163006907 metal binding site [ion binding]; metal-binding site 118163006908 active site 118163006909 I-site; other site 118163006910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163006911 Inward rectifier potassium channel; Region: IRK; pfam01007 118163006912 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163006913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006914 active site 118163006915 phosphorylation site [posttranslational modification] 118163006916 intermolecular recognition site; other site 118163006917 dimerization interface [polypeptide binding]; other site 118163006918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163006919 PAS fold; Region: PAS_3; pfam08447 118163006920 putative active site [active] 118163006921 heme pocket [chemical binding]; other site 118163006922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163006923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163006924 metal binding site [ion binding]; metal-binding site 118163006925 active site 118163006926 I-site; other site 118163006927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163006928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163006929 ATP binding site [chemical binding]; other site 118163006930 G-X-G motif; other site 118163006931 Response regulator receiver domain; Region: Response_reg; pfam00072 118163006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163006933 active site 118163006934 phosphorylation site [posttranslational modification] 118163006935 intermolecular recognition site; other site 118163006936 dimerization interface [polypeptide binding]; other site 118163006937 CHASE4 domain; Region: CHASE4; pfam05228 118163006938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 118163006939 dimerization interface [polypeptide binding]; other site 118163006940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163006941 PAS fold; Region: PAS_3; pfam08447 118163006942 putative active site [active] 118163006943 heme pocket [chemical binding]; other site 118163006944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163006945 dimer interface [polypeptide binding]; other site 118163006946 phosphorylation site [posttranslational modification] 118163006947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163006948 ATP binding site [chemical binding]; other site 118163006949 Mg2+ binding site [ion binding]; other site 118163006950 G-X-G motif; other site 118163006951 S-layer homology domain; Region: SLH; pfam00395 118163006952 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 118163006953 hypothetical protein; Reviewed; Region: PRK00024 118163006954 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 118163006955 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 118163006956 MPN+ (JAMM) motif; other site 118163006957 Zinc-binding site [ion binding]; other site 118163006958 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 118163006959 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 118163006960 nucleotide binding site [chemical binding]; other site 118163006961 putative NEF/HSP70 interaction site [polypeptide binding]; other site 118163006962 SBD interface [polypeptide binding]; other site 118163006963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163006964 active site 118163006965 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 118163006966 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 118163006967 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 118163006968 carotene isomerase; Region: carot_isom; TIGR02730 118163006969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163006970 hydroxyglutarate oxidase; Provisional; Region: PRK11728 118163006971 GAF domain; Region: GAF; pfam01590 118163006972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163006973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163006974 dimer interface [polypeptide binding]; other site 118163006975 phosphorylation site [posttranslational modification] 118163006976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163006977 ATP binding site [chemical binding]; other site 118163006978 Mg2+ binding site [ion binding]; other site 118163006979 G-X-G motif; other site 118163006980 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 118163006981 ABC1 family; Region: ABC1; cl17513 118163006982 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 118163006983 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163006984 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 118163006985 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 118163006986 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 118163006987 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 118163006988 Probable Catalytic site; other site 118163006989 metal-binding site 118163006990 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 118163006991 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 118163006992 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163006993 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163006994 active site 118163006995 ATP binding site [chemical binding]; other site 118163006996 substrate binding site [chemical binding]; other site 118163006997 activation loop (A-loop); other site 118163006998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163006999 binding surface 118163007000 TPR motif; other site 118163007001 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 118163007002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007003 binding surface 118163007004 TPR motif; other site 118163007005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007006 binding surface 118163007007 TPR motif; other site 118163007008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007009 binding surface 118163007010 TPR motif; other site 118163007011 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 118163007012 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 118163007013 active site 118163007014 catalytic site [active] 118163007015 methionine sulfoxide reductase B; Provisional; Region: PRK00222 118163007016 SelR domain; Region: SelR; pfam01641 118163007017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163007018 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 118163007019 active site 118163007020 metal binding site [ion binding]; metal-binding site 118163007021 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 118163007022 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 118163007023 dimer interface [polypeptide binding]; other site 118163007024 PYR/PP interface [polypeptide binding]; other site 118163007025 TPP binding site [chemical binding]; other site 118163007026 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 118163007027 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 118163007028 TPP-binding site [chemical binding]; other site 118163007029 dimer interface [polypeptide binding]; other site 118163007030 glycogen branching enzyme; Provisional; Region: PRK05402 118163007031 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 118163007032 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 118163007033 active site 118163007034 catalytic site [active] 118163007035 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 118163007036 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 118163007037 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 118163007038 putative active site [active] 118163007039 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 118163007040 putative active site [active] 118163007041 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 118163007042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007043 binding surface 118163007044 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163007045 TPR motif; other site 118163007046 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163007047 TPR repeat; Region: TPR_11; pfam13414 118163007048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007049 binding surface 118163007050 TPR motif; other site 118163007051 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 118163007052 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 118163007053 C-terminal domain interface [polypeptide binding]; other site 118163007054 GSH binding site (G-site) [chemical binding]; other site 118163007055 dimer interface [polypeptide binding]; other site 118163007056 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 118163007057 N-terminal domain interface [polypeptide binding]; other site 118163007058 dimer interface [polypeptide binding]; other site 118163007059 substrate binding pocket (H-site) [chemical binding]; other site 118163007060 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 118163007061 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 118163007062 Walker A/P-loop; other site 118163007063 ATP binding site [chemical binding]; other site 118163007064 Q-loop/lid; other site 118163007065 ABC transporter signature motif; other site 118163007066 Walker B; other site 118163007067 D-loop; other site 118163007068 H-loop/switch region; other site 118163007069 TOBE domain; Region: TOBE_2; pfam08402 118163007070 exonuclease SbcC; Region: sbcc; TIGR00618 118163007071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163007072 Walker A/P-loop; other site 118163007073 ATP binding site [chemical binding]; other site 118163007074 Q-loop/lid; other site 118163007075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163007076 ABC transporter signature motif; other site 118163007077 Walker B; other site 118163007078 D-loop; other site 118163007079 H-loop/switch region; other site 118163007080 Clp protease; Region: CLP_protease; pfam00574 118163007081 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 118163007082 oligomer interface [polypeptide binding]; other site 118163007083 active site residues [active] 118163007084 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 118163007085 putative hydrophobic ligand binding site [chemical binding]; other site 118163007086 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163007087 dimerization interface [polypeptide binding]; other site 118163007088 putative DNA binding site [nucleotide binding]; other site 118163007089 putative Zn2+ binding site [ion binding]; other site 118163007090 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 118163007091 active site 118163007092 dimer interface [polypeptide binding]; other site 118163007093 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 118163007094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163007095 active site 118163007096 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 118163007097 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 118163007098 active site 118163007099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163007100 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163007101 proline aminopeptidase P II; Provisional; Region: PRK10879 118163007102 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 118163007103 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 118163007104 active site 118163007105 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 118163007106 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163007107 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007108 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163007112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163007113 Domain of unknown function (DUF202); Region: DUF202; cl09954 118163007114 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 118163007115 putative substrate binding pocket [chemical binding]; other site 118163007116 catalytic triad [active] 118163007117 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 118163007118 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 118163007119 putative active site [active] 118163007120 oxyanion strand; other site 118163007121 catalytic triad [active] 118163007122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163007123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007124 active site 118163007125 phosphorylation site [posttranslational modification] 118163007126 intermolecular recognition site; other site 118163007127 dimerization interface [polypeptide binding]; other site 118163007128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163007129 DNA binding site [nucleotide binding] 118163007130 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007132 active site 118163007133 phosphorylation site [posttranslational modification] 118163007134 intermolecular recognition site; other site 118163007135 dimerization interface [polypeptide binding]; other site 118163007136 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 118163007137 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 118163007138 spermidine synthase; Provisional; Region: PRK00811 118163007139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007140 S-adenosylmethionine binding site [chemical binding]; other site 118163007141 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 118163007142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163007143 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 118163007144 Dehydroquinase class II; Region: DHquinase_II; pfam01220 118163007145 trimer interface [polypeptide binding]; other site 118163007146 active site 118163007147 dimer interface [polypeptide binding]; other site 118163007148 competence damage-inducible protein A; Provisional; Region: PRK00549 118163007149 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 118163007150 putative MPT binding site; other site 118163007151 Competence-damaged protein; Region: CinA; pfam02464 118163007152 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 118163007153 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 118163007154 Mg++ binding site [ion binding]; other site 118163007155 putative catalytic motif [active] 118163007156 substrate binding site [chemical binding]; other site 118163007157 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 118163007158 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 118163007159 dimer interface [polypeptide binding]; other site 118163007160 active site 118163007161 glycine-pyridoxal phosphate binding site [chemical binding]; other site 118163007162 folate binding site [chemical binding]; other site 118163007163 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 118163007164 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 118163007165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 118163007166 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 118163007167 tocopherol O-methyltransferase; Region: PLN02244 118163007168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007169 S-adenosylmethionine binding site [chemical binding]; other site 118163007170 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163007171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007174 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007178 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007179 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 118163007180 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 118163007181 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 118163007182 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 118163007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007184 S-adenosylmethionine binding site [chemical binding]; other site 118163007185 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 118163007186 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 118163007187 oligomerization interface [polypeptide binding]; other site 118163007188 active site 118163007189 metal binding site [ion binding]; metal-binding site 118163007190 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 118163007191 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 118163007192 SmpB-tmRNA interface; other site 118163007193 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 118163007194 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 118163007195 CpeS-like protein; Region: CpeS; pfam09367 118163007196 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 118163007197 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 118163007198 active site 118163007199 interdomain interaction site; other site 118163007200 putative metal-binding site [ion binding]; other site 118163007201 nucleotide binding site [chemical binding]; other site 118163007202 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 118163007203 domain I; other site 118163007204 DNA binding groove [nucleotide binding] 118163007205 phosphate binding site [ion binding]; other site 118163007206 domain II; other site 118163007207 domain III; other site 118163007208 nucleotide binding site [chemical binding]; other site 118163007209 catalytic site [active] 118163007210 domain IV; other site 118163007211 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 118163007212 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 118163007213 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 118163007214 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 118163007215 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 118163007216 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163007217 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 118163007218 4Fe-4S binding domain; Region: Fer4; pfam00037 118163007219 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 118163007220 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 118163007221 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163007222 catalytic residues [active] 118163007223 molecular chaperone DnaK; Provisional; Region: PRK13410 118163007224 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 118163007225 nucleotide binding site [chemical binding]; other site 118163007226 NEF interaction site [polypeptide binding]; other site 118163007227 SBD interface [polypeptide binding]; other site 118163007228 chaperone protein DnaJ; Provisional; Region: PRK14299 118163007229 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163007230 HSP70 interaction site [polypeptide binding]; other site 118163007231 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 118163007232 dimer interface [polypeptide binding]; other site 118163007233 light-harvesting-like protein 3; Provisional; Region: PLN00014 118163007234 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 118163007235 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 118163007236 oligomer interface [polypeptide binding]; other site 118163007237 active site residues [active] 118163007238 Clp protease; Region: CLP_protease; pfam00574 118163007239 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 118163007240 oligomer interface [polypeptide binding]; other site 118163007241 active site residues [active] 118163007242 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163007243 Chain length determinant protein; Region: Wzz; pfam02706 118163007244 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 118163007245 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 118163007246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163007247 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163007248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163007249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163007250 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163007251 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 118163007252 S-layer homology domain; Region: SLH; pfam00395 118163007253 S-layer homology domain; Region: SLH; pfam00395 118163007254 Cupin domain; Region: Cupin_2; cl17218 118163007255 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 118163007256 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 118163007257 S17 interaction site [polypeptide binding]; other site 118163007258 S8 interaction site; other site 118163007259 16S rRNA interaction site [nucleotide binding]; other site 118163007260 streptomycin interaction site [chemical binding]; other site 118163007261 23S rRNA interaction site [nucleotide binding]; other site 118163007262 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 118163007263 30S ribosomal protein S7; Validated; Region: PRK05302 118163007264 elongation factor G; Reviewed; Region: PRK00007 118163007265 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 118163007266 G1 box; other site 118163007267 putative GEF interaction site [polypeptide binding]; other site 118163007268 GTP/Mg2+ binding site [chemical binding]; other site 118163007269 Switch I region; other site 118163007270 G2 box; other site 118163007271 G3 box; other site 118163007272 Switch II region; other site 118163007273 G4 box; other site 118163007274 G5 box; other site 118163007275 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 118163007276 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 118163007277 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 118163007278 elongation factor Tu; Region: tufA; CHL00071 118163007279 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 118163007280 G1 box; other site 118163007281 GEF interaction site [polypeptide binding]; other site 118163007282 GTP/Mg2+ binding site [chemical binding]; other site 118163007283 Switch I region; other site 118163007284 G2 box; other site 118163007285 G3 box; other site 118163007286 Switch II region; other site 118163007287 G4 box; other site 118163007288 G5 box; other site 118163007289 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 118163007290 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 118163007291 Antibiotic Binding Site [chemical binding]; other site 118163007292 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 118163007293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 118163007294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163007295 Coenzyme A binding pocket [chemical binding]; other site 118163007296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163007297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163007298 dimer interface [polypeptide binding]; other site 118163007299 phosphorylation site [posttranslational modification] 118163007300 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 118163007301 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 118163007302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007303 S-adenosylmethionine binding site [chemical binding]; other site 118163007304 Tic22-like family; Region: Tic22; pfam04278 118163007305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163007306 Coenzyme A binding pocket [chemical binding]; other site 118163007307 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163007308 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 118163007309 Protein of unknown function (DUF615); Region: DUF615; cl01147 118163007310 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 118163007311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163007312 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 118163007313 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163007314 TrkA-N domain; Region: TrkA_N; pfam02254 118163007315 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 118163007316 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 118163007317 Predicted transcriptional regulator [Transcription]; Region: COG1959 118163007318 Transcriptional regulator; Region: Rrf2; cl17282 118163007319 Uncharacterized conserved protein [Function unknown]; Region: COG3791 118163007320 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 118163007321 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 118163007322 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163007323 P-loop; other site 118163007324 Magnesium ion binding site [ion binding]; other site 118163007325 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 118163007326 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 118163007327 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 118163007328 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 118163007329 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 118163007330 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 118163007331 putative dimer interface [polypeptide binding]; other site 118163007332 [2Fe-2S] cluster binding site [ion binding]; other site 118163007333 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163007334 dimer interface [polypeptide binding]; other site 118163007335 [2Fe-2S] cluster binding site [ion binding]; other site 118163007336 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 118163007337 SLBB domain; Region: SLBB; pfam10531 118163007338 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 118163007339 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 118163007340 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163007341 catalytic loop [active] 118163007342 iron binding site [ion binding]; other site 118163007343 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 118163007344 4Fe-4S binding domain; Region: Fer4; pfam00037 118163007345 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 118163007346 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 118163007347 hypothetical protein; Provisional; Region: PRK07236 118163007348 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 118163007349 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 118163007350 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 118163007351 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 118163007352 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 118163007353 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163007354 dimer interface [polypeptide binding]; other site 118163007355 [2Fe-2S] cluster binding site [ion binding]; other site 118163007356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163007357 PAS domain; Region: PAS_9; pfam13426 118163007358 putative active site [active] 118163007359 heme pocket [chemical binding]; other site 118163007360 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 118163007361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 118163007362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163007363 dimer interface [polypeptide binding]; other site 118163007364 conserved gate region; other site 118163007365 putative PBP binding loops; other site 118163007366 ABC-ATPase subunit interface; other site 118163007367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163007368 active site 118163007369 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 118163007370 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 118163007371 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 118163007372 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 118163007373 putative NAD(P) binding site [chemical binding]; other site 118163007374 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 118163007375 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 118163007376 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 118163007377 Peptidase family M50; Region: Peptidase_M50; pfam02163 118163007378 active site 118163007379 putative substrate binding region [chemical binding]; other site 118163007380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 118163007381 ornithine carbamoyltransferase; Provisional; Region: PRK00779 118163007382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 118163007383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 118163007384 Proline dehydrogenase; Region: Pro_dh; pfam01619 118163007385 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 118163007386 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 118163007387 Glutamate binding site [chemical binding]; other site 118163007388 homodimer interface [polypeptide binding]; other site 118163007389 NAD binding site [chemical binding]; other site 118163007390 catalytic residues [active] 118163007391 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 118163007392 active site 118163007393 catalytic residues [active] 118163007394 metal binding site [ion binding]; metal-binding site 118163007395 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163007396 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163007397 active site 118163007398 ATP binding site [chemical binding]; other site 118163007399 substrate binding site [chemical binding]; other site 118163007400 activation loop (A-loop); other site 118163007401 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163007402 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007403 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007404 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007405 CpeS-like protein; Region: CpeS; pfam09367 118163007406 HEAT repeats; Region: HEAT_2; pfam13646 118163007407 HEAT repeats; Region: HEAT_2; pfam13646 118163007408 HEAT repeats; Region: HEAT_2; pfam13646 118163007409 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 118163007410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163007411 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 118163007412 nudix motif; other site 118163007413 argininosuccinate lyase; Provisional; Region: PRK00855 118163007414 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 118163007415 active sites [active] 118163007416 tetramer interface [polypeptide binding]; other site 118163007417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163007418 GAF domain; Region: GAF; cl17456 118163007419 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 118163007420 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 118163007421 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 118163007422 aromatic arch; other site 118163007423 DCoH dimer interaction site [polypeptide binding]; other site 118163007424 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 118163007425 DCoH tetramer interaction site [polypeptide binding]; other site 118163007426 substrate binding site [chemical binding]; other site 118163007427 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163007428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 118163007429 active site 118163007430 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 118163007431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163007432 active site 118163007433 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163007434 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 118163007435 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 118163007436 Active site cavity [active] 118163007437 catalytic acid [active] 118163007438 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 118163007439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007440 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163007441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007442 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007443 integron integrase; Region: integrase_gron; TIGR02249 118163007444 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 118163007445 Int/Topo IB signature motif; other site 118163007446 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 118163007447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163007448 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 118163007449 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 118163007450 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 118163007451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 118163007452 DNA-binding site [nucleotide binding]; DNA binding site 118163007453 UTRA domain; Region: UTRA; pfam07702 118163007454 Guanylate kinase; Region: Guanylate_kin; pfam00625 118163007455 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 118163007456 active site 118163007457 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 118163007458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 118163007459 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 118163007460 active site 118163007461 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 118163007462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163007463 Walker A/P-loop; other site 118163007464 ATP binding site [chemical binding]; other site 118163007465 Q-loop/lid; other site 118163007466 ABC transporter signature motif; other site 118163007467 Walker B; other site 118163007468 D-loop; other site 118163007469 H-loop/switch region; other site 118163007470 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 118163007471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 118163007472 Walker A/P-loop; other site 118163007473 ATP binding site [chemical binding]; other site 118163007474 Q-loop/lid; other site 118163007475 ABC transporter signature motif; other site 118163007476 Walker B; other site 118163007477 D-loop; other site 118163007478 H-loop/switch region; other site 118163007479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 118163007480 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 118163007481 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 118163007482 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 118163007483 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 118163007484 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 118163007485 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 118163007486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163007487 dimer interface [polypeptide binding]; other site 118163007488 conserved gate region; other site 118163007489 putative PBP binding loops; other site 118163007490 ABC-ATPase subunit interface; other site 118163007491 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 118163007492 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 118163007493 Walker A/P-loop; other site 118163007494 ATP binding site [chemical binding]; other site 118163007495 Q-loop/lid; other site 118163007496 ABC transporter signature motif; other site 118163007497 Walker B; other site 118163007498 D-loop; other site 118163007499 H-loop/switch region; other site 118163007500 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 118163007501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 118163007502 substrate binding pocket [chemical binding]; other site 118163007503 membrane-bound complex binding site; other site 118163007504 hinge residues; other site 118163007505 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 118163007506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163007507 Walker A motif; other site 118163007508 ATP binding site [chemical binding]; other site 118163007509 Walker B motif; other site 118163007510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 118163007511 Integrase core domain; Region: rve; pfam00665 118163007512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 118163007513 Uncharacterized conserved protein [Function unknown]; Region: COG3391 118163007514 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 118163007515 Domain of unknown function (DUF305); Region: DUF305; pfam03713 118163007516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163007517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007518 active site 118163007519 phosphorylation site [posttranslational modification] 118163007520 intermolecular recognition site; other site 118163007521 dimerization interface [polypeptide binding]; other site 118163007522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163007523 DNA binding site [nucleotide binding] 118163007524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163007525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163007526 dimerization interface [polypeptide binding]; other site 118163007527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163007528 dimer interface [polypeptide binding]; other site 118163007529 phosphorylation site [posttranslational modification] 118163007530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163007531 ATP binding site [chemical binding]; other site 118163007532 Mg2+ binding site [ion binding]; other site 118163007533 G-X-G motif; other site 118163007534 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163007535 structural tetrad; other site 118163007536 PQQ-like domain; Region: PQQ_2; pfam13360 118163007537 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163007538 Protein of unknown function (DUF433); Region: DUF433; cl01030 118163007539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163007540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163007541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163007542 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 118163007543 Coenzyme A binding pocket [chemical binding]; other site 118163007544 Putative addiction module component; Region: Unstab_antitox; pfam09720 118163007545 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 118163007546 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 118163007547 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 118163007548 Protein of unknown function (DUF433); Region: DUF433; cl01030 118163007549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 118163007550 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163007551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 118163007552 Transposase; Region: HTH_Tnp_1; cl17663 118163007553 AMIN domain; Region: AMIN; pfam11741 118163007554 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163007555 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 118163007556 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 118163007557 Clp amino terminal domain; Region: Clp_N; pfam02861 118163007558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163007559 Walker A motif; other site 118163007560 ATP binding site [chemical binding]; other site 118163007561 Walker B motif; other site 118163007562 arginine finger; other site 118163007563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163007564 Walker A motif; other site 118163007565 ATP binding site [chemical binding]; other site 118163007566 Walker B motif; other site 118163007567 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 118163007568 DNA gyrase subunit A; Validated; Region: PRK05560 118163007569 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 118163007570 CAP-like domain; other site 118163007571 active site 118163007572 primary dimer interface [polypeptide binding]; other site 118163007573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163007574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163007575 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 118163007576 Response regulator receiver domain; Region: Response_reg; pfam00072 118163007577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007578 active site 118163007579 phosphorylation site [posttranslational modification] 118163007580 intermolecular recognition site; other site 118163007581 dimerization interface [polypeptide binding]; other site 118163007582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007583 binding surface 118163007584 TPR motif; other site 118163007585 TPR repeat; Region: TPR_11; pfam13414 118163007586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007587 TPR motif; other site 118163007588 binding surface 118163007589 TPR repeat; Region: TPR_11; pfam13414 118163007590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007591 binding surface 118163007592 TPR repeat; Region: TPR_11; pfam13414 118163007593 TPR motif; other site 118163007594 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 118163007595 Pantoate-beta-alanine ligase; Region: PanC; cd00560 118163007596 active site 118163007597 ATP-binding site [chemical binding]; other site 118163007598 pantoate-binding site; other site 118163007599 HXXH motif; other site 118163007600 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 118163007601 CMP-binding site; other site 118163007602 The sites determining sugar specificity; other site 118163007603 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 118163007604 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 118163007605 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 118163007606 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 118163007607 dimerization interface [polypeptide binding]; other site 118163007608 putative ATP binding site [chemical binding]; other site 118163007609 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 118163007610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163007611 FeS/SAM binding site; other site 118163007612 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 118163007613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007614 S-adenosylmethionine binding site [chemical binding]; other site 118163007615 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 118163007616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163007617 FeS/SAM binding site; other site 118163007618 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 118163007619 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 118163007620 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 118163007621 putative active site [active] 118163007622 putative catalytic site [active] 118163007623 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 118163007624 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 118163007625 Cobalt transport protein; Region: CbiQ; pfam02361 118163007626 anthranilate synthase component I-like protein; Validated; Region: PRK05940 118163007627 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 118163007628 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 118163007629 CHAT domain; Region: CHAT; cl17868 118163007630 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 118163007631 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 118163007632 putative ligand binding site [chemical binding]; other site 118163007633 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 118163007634 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 118163007635 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 118163007636 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 118163007637 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 118163007638 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 118163007639 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 118163007640 G1 box; other site 118163007641 GTP/Mg2+ binding site [chemical binding]; other site 118163007642 G2 box; other site 118163007643 Switch I region; other site 118163007644 G3 box; other site 118163007645 Switch II region; other site 118163007646 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 118163007647 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 118163007648 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 118163007649 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 118163007650 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 118163007651 active site 118163007652 dimer interface [polypeptide binding]; other site 118163007653 motif 1; other site 118163007654 motif 2; other site 118163007655 motif 3; other site 118163007656 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 118163007657 anticodon binding site; other site 118163007658 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 118163007659 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163007660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163007661 active site 118163007662 ATP binding site [chemical binding]; other site 118163007663 substrate binding site [chemical binding]; other site 118163007664 activation loop (A-loop); other site 118163007665 carotene isomerase; Region: carot_isom; TIGR02730 118163007666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163007667 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 118163007668 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 118163007669 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 118163007670 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 118163007671 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 118163007672 GSH binding site [chemical binding]; other site 118163007673 catalytic residues [active] 118163007674 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 118163007675 nucleoside/Zn binding site; other site 118163007676 dimer interface [polypeptide binding]; other site 118163007677 catalytic motif [active] 118163007678 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163007679 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 118163007680 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 118163007681 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 118163007682 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 118163007683 Psb28 protein; Region: Psb28; pfam03912 118163007684 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 118163007685 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 118163007686 putative NAD(P) binding site [chemical binding]; other site 118163007687 putative active site [active] 118163007688 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 118163007689 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 118163007690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 118163007691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163007692 Coenzyme A binding pocket [chemical binding]; other site 118163007693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 118163007694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163007695 Coenzyme A binding pocket [chemical binding]; other site 118163007696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 118163007697 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 118163007698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163007699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 118163007700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 118163007701 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 118163007702 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 118163007703 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 118163007704 putative efflux protein, MATE family; Region: matE; TIGR00797 118163007705 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 118163007706 conserved cys residue [active] 118163007707 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 118163007708 Protein of unknown function DUF104; Region: DUF104; cl11530 118163007709 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 118163007710 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007711 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007712 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007713 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 118163007714 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007715 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007716 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007717 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 118163007718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163007719 dimer interface [polypeptide binding]; other site 118163007720 phosphorylation site [posttranslational modification] 118163007721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163007722 ATP binding site [chemical binding]; other site 118163007723 Mg2+ binding site [ion binding]; other site 118163007724 G-X-G motif; other site 118163007725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163007726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007727 active site 118163007728 phosphorylation site [posttranslational modification] 118163007729 intermolecular recognition site; other site 118163007730 dimerization interface [polypeptide binding]; other site 118163007731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163007732 DNA binding site [nucleotide binding] 118163007733 AMIN domain; Region: AMIN; pfam11741 118163007734 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 118163007735 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 118163007736 active site 118163007737 metal binding site [ion binding]; metal-binding site 118163007738 glutamate racemase; Provisional; Region: PRK00865 118163007739 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 118163007740 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 118163007741 homotetramer interface [polypeptide binding]; other site 118163007742 ligand binding site [chemical binding]; other site 118163007743 catalytic site [active] 118163007744 NAD binding site [chemical binding]; other site 118163007745 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163007746 ligand binding site [chemical binding]; other site 118163007747 flexible hinge region; other site 118163007748 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 118163007749 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 118163007750 putative active site [active] 118163007751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163007752 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 118163007753 Walker A/P-loop; other site 118163007754 ATP binding site [chemical binding]; other site 118163007755 Q-loop/lid; other site 118163007756 ABC transporter signature motif; other site 118163007757 Walker B; other site 118163007758 D-loop; other site 118163007759 H-loop/switch region; other site 118163007760 Homeodomain-like domain; Region: HTH_23; pfam13384 118163007761 Winged helix-turn helix; Region: HTH_29; pfam13551 118163007762 Winged helix-turn helix; Region: HTH_33; pfam13592 118163007763 Response regulator receiver domain; Region: Response_reg; pfam00072 118163007764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007765 active site 118163007766 phosphorylation site [posttranslational modification] 118163007767 intermolecular recognition site; other site 118163007768 dimerization interface [polypeptide binding]; other site 118163007769 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 118163007770 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163007771 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163007772 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 118163007773 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 118163007774 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 118163007775 CoA binding domain; Region: CoA_binding_2; pfam13380 118163007776 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 118163007777 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 118163007778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 118163007779 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 118163007780 ribonuclease Z; Region: RNase_Z; TIGR02651 118163007781 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 118163007782 Active_site [active] 118163007783 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 118163007784 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 118163007785 HflX GTPase family; Region: HflX; cd01878 118163007786 G1 box; other site 118163007787 GTP/Mg2+ binding site [chemical binding]; other site 118163007788 Switch I region; other site 118163007789 G2 box; other site 118163007790 G3 box; other site 118163007791 Switch II region; other site 118163007792 G4 box; other site 118163007793 G5 box; other site 118163007794 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 118163007795 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 118163007796 active site 118163007797 catalytic residues [active] 118163007798 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 118163007799 catalytic residues [active] 118163007800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163007801 putative substrate translocation pore; other site 118163007802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 118163007803 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 118163007804 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 118163007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163007806 dimer interface [polypeptide binding]; other site 118163007807 conserved gate region; other site 118163007808 putative PBP binding loops; other site 118163007809 ABC-ATPase subunit interface; other site 118163007810 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 118163007811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163007812 dimer interface [polypeptide binding]; other site 118163007813 conserved gate region; other site 118163007814 putative PBP binding loops; other site 118163007815 ABC-ATPase subunit interface; other site 118163007816 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 118163007817 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 118163007818 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 118163007819 TPP-binding site [chemical binding]; other site 118163007820 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 118163007821 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 118163007822 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163007823 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 118163007824 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 118163007825 iron-sulfur cluster [ion binding]; other site 118163007826 [2Fe-2S] cluster binding site [ion binding]; other site 118163007827 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 118163007828 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 118163007829 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163007830 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 118163007831 Predicted membrane protein [Function unknown]; Region: COG3463 118163007832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163007833 catalytic core [active] 118163007834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163007835 catalytic core [active] 118163007836 glyoxylate reductase; Reviewed; Region: PRK13243 118163007837 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 118163007838 dimerization interface [polypeptide binding]; other site 118163007839 ligand binding site [chemical binding]; other site 118163007840 NADP binding site [chemical binding]; other site 118163007841 catalytic site [active] 118163007842 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 118163007843 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 118163007844 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 118163007845 putative RNA binding site [nucleotide binding]; other site 118163007846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163007847 S-adenosylmethionine binding site [chemical binding]; other site 118163007848 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 118163007849 NMT1-like family; Region: NMT1_2; pfam13379 118163007850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163007851 dimerization interface [polypeptide binding]; other site 118163007852 putative DNA binding site [nucleotide binding]; other site 118163007853 putative Zn2+ binding site [ion binding]; other site 118163007854 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 118163007855 DsrE/DsrF-like family; Region: DrsE; pfam02635 118163007856 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 118163007857 active site residue [active] 118163007858 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 118163007859 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 118163007860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163007861 dimerization interface [polypeptide binding]; other site 118163007862 putative DNA binding site [nucleotide binding]; other site 118163007863 putative Zn2+ binding site [ion binding]; other site 118163007864 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163007865 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163007866 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163007867 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 118163007868 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 118163007869 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 118163007870 nudix motif; other site 118163007871 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163007872 Protein export membrane protein; Region: SecD_SecF; cl14618 118163007873 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163007874 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007875 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007877 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007878 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 118163007879 L-asparaginase II; Region: Asparaginase_II; cl01842 118163007880 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 118163007881 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 118163007882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163007883 Zn2+ binding site [ion binding]; other site 118163007884 Mg2+ binding site [ion binding]; other site 118163007885 WYL domain; Region: WYL; pfam13280 118163007886 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 118163007887 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 118163007888 trmE is a tRNA modification GTPase; Region: trmE; cd04164 118163007889 G1 box; other site 118163007890 GTP/Mg2+ binding site [chemical binding]; other site 118163007891 Switch I region; other site 118163007892 G2 box; other site 118163007893 Switch II region; other site 118163007894 G3 box; other site 118163007895 G4 box; other site 118163007896 G5 box; other site 118163007897 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 118163007898 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 118163007899 protein I interface; other site 118163007900 D2 interface; other site 118163007901 protein T interface; other site 118163007902 chlorophyll binding site; other site 118163007903 beta carotene binding site; other site 118163007904 pheophytin binding site; other site 118163007905 manganese-stabilizing polypeptide interface; other site 118163007906 CP43 interface; other site 118163007907 protein L interface; other site 118163007908 oxygen evolving complex binding site; other site 118163007909 bromide binding site; other site 118163007910 quinone binding site; other site 118163007911 Fe binding site [ion binding]; other site 118163007912 core light harvesting interface; other site 118163007913 cytochrome b559 alpha subunit interface; other site 118163007914 cytochrome c-550 interface; other site 118163007915 protein J interface; other site 118163007916 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 118163007917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163007918 FeS/SAM binding site; other site 118163007919 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 118163007920 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 118163007921 catalytic residues [active] 118163007922 Ion channel; Region: Ion_trans_2; pfam07885 118163007923 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163007924 TrkA-N domain; Region: TrkA_N; pfam02254 118163007925 TrkA-C domain; Region: TrkA_C; pfam02080 118163007926 acetylornithine aminotransferase; Provisional; Region: PRK02627 118163007927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 118163007928 inhibitor-cofactor binding pocket; inhibition site 118163007929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163007930 catalytic residue [active] 118163007931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 118163007932 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 118163007933 inhibitor-cofactor binding pocket; inhibition site 118163007934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163007935 catalytic residue [active] 118163007936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007937 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163007938 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163007940 hypothetical protein; Reviewed; Region: PRK12497 118163007941 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 118163007942 Ycf39; Provisional; Region: ycf39; CHL00194 118163007943 NAD(P) binding site [chemical binding]; other site 118163007944 putative active site [active] 118163007945 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 118163007946 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 118163007947 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 118163007948 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 118163007949 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 118163007950 ligand binding site [chemical binding]; other site 118163007951 homodimer interface [polypeptide binding]; other site 118163007952 NAD(P) binding site [chemical binding]; other site 118163007953 trimer interface B [polypeptide binding]; other site 118163007954 trimer interface A [polypeptide binding]; other site 118163007955 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 118163007956 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 118163007957 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 118163007958 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 118163007959 alpha subunit interaction interface [polypeptide binding]; other site 118163007960 Walker A motif; other site 118163007961 ATP binding site [chemical binding]; other site 118163007962 Walker B motif; other site 118163007963 inhibitor binding site; inhibition site 118163007964 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 118163007965 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 118163007966 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 118163007967 substrate binding pocket [chemical binding]; other site 118163007968 chain length determination region; other site 118163007969 substrate-Mg2+ binding site; other site 118163007970 catalytic residues [active] 118163007971 aspartate-rich region 1; other site 118163007972 active site lid residues [active] 118163007973 aspartate-rich region 2; other site 118163007974 Divergent PAP2 family; Region: DUF212; pfam02681 118163007975 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 118163007976 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 118163007977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163007978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163007979 active site 118163007980 phosphorylation site [posttranslational modification] 118163007981 intermolecular recognition site; other site 118163007982 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 118163007983 CHASE2 domain; Region: CHASE2; pfam05226 118163007984 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 118163007985 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 118163007986 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163007987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163007988 binding surface 118163007989 TPR motif; other site 118163007990 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163007991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163007992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 118163007993 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 118163007994 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 118163007995 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 118163007996 catalytic triad [active] 118163007997 putative active site [active] 118163007998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163007999 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 118163008000 putative ADP-binding pocket [chemical binding]; other site 118163008001 glycogen synthase; Provisional; Region: glgA; PRK00654 118163008002 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 118163008003 ADP-binding pocket [chemical binding]; other site 118163008004 homodimer interface [polypeptide binding]; other site 118163008005 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 118163008006 DNA-binding interface [nucleotide binding]; DNA binding site 118163008007 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 118163008008 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 118163008009 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 118163008010 catalytic site [active] 118163008011 subunit interface [polypeptide binding]; other site 118163008012 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 118163008013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 118163008014 anti sigma factor interaction site; other site 118163008015 regulatory phosphorylation site [posttranslational modification]; other site 118163008016 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 118163008017 dimerization interface [polypeptide binding]; other site 118163008018 active site 118163008019 metal binding site [ion binding]; metal-binding site 118163008020 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 118163008021 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 118163008022 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 118163008023 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 118163008024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 118163008025 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 118163008026 active site 118163008027 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163008028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163008029 S-adenosylmethionine binding site [chemical binding]; other site 118163008030 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 118163008031 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 118163008032 substrate binding site [chemical binding]; other site 118163008033 glutamase interaction surface [polypeptide binding]; other site 118163008034 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 118163008035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163008036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163008037 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 118163008038 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 118163008039 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163008040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163008041 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163008042 acyl carrier protein; Provisional; Region: acpP; PRK00982 118163008043 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 118163008044 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 118163008045 dimer interface [polypeptide binding]; other site 118163008046 active site 118163008047 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 118163008048 transketolase; Region: PLN02790 118163008049 TPP-binding site [chemical binding]; other site 118163008050 dimer interface [polypeptide binding]; other site 118163008051 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 118163008052 PYR/PP interface [polypeptide binding]; other site 118163008053 dimer interface [polypeptide binding]; other site 118163008054 TPP binding site [chemical binding]; other site 118163008055 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 118163008056 TrkA-N domain; Region: TrkA_N; pfam02254 118163008057 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163008058 TrkA-N domain; Region: TrkA_N; pfam02254 118163008059 TrkA-C domain; Region: TrkA_C; pfam02080 118163008060 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 118163008061 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 118163008062 Ribosomal subunit 39S; Region: Ribosomal_L50; pfam10501 118163008063 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 118163008064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 118163008065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 118163008066 catalytic residue [active] 118163008067 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 118163008068 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 118163008069 G1 box; other site 118163008070 putative GEF interaction site [polypeptide binding]; other site 118163008071 GTP/Mg2+ binding site [chemical binding]; other site 118163008072 Switch I region; other site 118163008073 G2 box; other site 118163008074 G3 box; other site 118163008075 Switch II region; other site 118163008076 G4 box; other site 118163008077 G5 box; other site 118163008078 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 118163008079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 118163008080 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 118163008081 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 118163008082 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 118163008083 active site 118163008084 HIGH motif; other site 118163008085 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 118163008086 KMSKS motif; other site 118163008087 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 118163008088 tRNA binding surface [nucleotide binding]; other site 118163008089 anticodon binding site; other site 118163008090 DsrE/DsrF-like family; Region: DrsE; pfam02635 118163008091 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 118163008092 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 118163008093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163008094 DsrE/DsrF-like family; Region: DrsE; pfam02635 118163008095 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 118163008096 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 118163008097 dimer interface [polypeptide binding]; other site 118163008098 active site 118163008099 aspartate-rich active site metal binding site; other site 118163008100 allosteric magnesium binding site [ion binding]; other site 118163008101 Schiff base residues; other site 118163008102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008103 binding surface 118163008104 TPR motif; other site 118163008105 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 118163008108 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 118163008109 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 118163008110 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 118163008111 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 118163008112 oligomeric interface; other site 118163008113 homodimer interface [polypeptide binding]; other site 118163008114 putative active site [active] 118163008115 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 118163008116 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 118163008117 Surface antigen; Region: Bac_surface_Ag; pfam01103 118163008118 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163008119 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 118163008120 putative active site [active] 118163008121 homotetrameric interface [polypeptide binding]; other site 118163008122 metal binding site [ion binding]; metal-binding site 118163008123 M28 Zn-Peptidases; Region: M28_like_1; cd05640 118163008124 Peptidase family M28; Region: Peptidase_M28; pfam04389 118163008125 metal binding site [ion binding]; metal-binding site 118163008126 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 118163008127 nucleotide binding site [chemical binding]; other site 118163008128 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 118163008129 Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683 118163008130 Peptidase family M48; Region: Peptidase_M48; cl12018 118163008131 CHASE2 domain; Region: CHASE2; pfam05226 118163008132 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 118163008133 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 118163008134 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 118163008135 cofactor binding site; other site 118163008136 DNA binding site [nucleotide binding] 118163008137 substrate interaction site [chemical binding]; other site 118163008138 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 118163008139 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 118163008140 putative catalytic site [active] 118163008141 putative phosphate binding site [ion binding]; other site 118163008142 active site 118163008143 metal binding site A [ion binding]; metal-binding site 118163008144 DNA binding site [nucleotide binding] 118163008145 putative AP binding site [nucleotide binding]; other site 118163008146 putative metal binding site B [ion binding]; other site 118163008147 flavoprotein, HI0933 family; Region: TIGR00275 118163008148 light-harvesting-like protein 3; Provisional; Region: PLN00014 118163008149 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 118163008150 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163008151 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 118163008152 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163008153 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163008154 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 118163008155 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163008156 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163008157 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 118163008158 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 118163008159 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 118163008160 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 118163008161 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008163 active site 118163008164 phosphorylation site [posttranslational modification] 118163008165 intermolecular recognition site; other site 118163008166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008167 dimerization interface [polypeptide binding]; other site 118163008168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163008169 dimer interface [polypeptide binding]; other site 118163008170 phosphorylation site [posttranslational modification] 118163008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008172 ATP binding site [chemical binding]; other site 118163008173 Mg2+ binding site [ion binding]; other site 118163008174 G-X-G motif; other site 118163008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008176 active site 118163008177 phosphorylation site [posttranslational modification] 118163008178 intermolecular recognition site; other site 118163008179 dimerization interface [polypeptide binding]; other site 118163008180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163008181 dimer interface [polypeptide binding]; other site 118163008182 phosphorylation site [posttranslational modification] 118163008183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008184 ATP binding site [chemical binding]; other site 118163008185 Mg2+ binding site [ion binding]; other site 118163008186 G-X-G motif; other site 118163008187 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008189 active site 118163008190 phosphorylation site [posttranslational modification] 118163008191 intermolecular recognition site; other site 118163008192 dimerization interface [polypeptide binding]; other site 118163008193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008195 active site 118163008196 phosphorylation site [posttranslational modification] 118163008197 intermolecular recognition site; other site 118163008198 dimerization interface [polypeptide binding]; other site 118163008199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163008200 DNA binding residues [nucleotide binding] 118163008201 dimerization interface [polypeptide binding]; other site 118163008202 CsbD-like; Region: CsbD; cl17424 118163008203 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 118163008204 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 118163008205 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 118163008206 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 118163008207 DNA primase; Validated; Region: dnaG; PRK05667 118163008208 CHC2 zinc finger; Region: zf-CHC2; pfam01807 118163008209 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 118163008210 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 118163008211 active site 118163008212 metal binding site [ion binding]; metal-binding site 118163008213 interdomain interaction site; other site 118163008214 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 118163008215 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 118163008216 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 118163008217 inhibitor-cofactor binding pocket; inhibition site 118163008218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163008219 catalytic residue [active] 118163008220 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 118163008221 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 118163008222 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 118163008223 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163008224 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 118163008225 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 118163008226 hypothetical protein; Provisional; Region: PRK07377 118163008227 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 118163008228 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 118163008229 Domain of unknown function DUF20; Region: UPF0118; pfam01594 118163008230 hydrolase, alpha/beta fold family protein; Region: PLN02824 118163008231 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 118163008232 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 118163008233 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 118163008234 Cl- selectivity filter; other site 118163008235 Cl- binding residues [ion binding]; other site 118163008236 pore gating glutamate residue; other site 118163008237 dimer interface [polypeptide binding]; other site 118163008238 H+/Cl- coupling transport residue; other site 118163008239 FOG: CBS domain [General function prediction only]; Region: COG0517 118163008240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 118163008241 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 118163008242 Ligand Binding Site [chemical binding]; other site 118163008243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163008244 Ligand Binding Site [chemical binding]; other site 118163008245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163008246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008247 active site 118163008248 phosphorylation site [posttranslational modification] 118163008249 intermolecular recognition site; other site 118163008250 dimerization interface [polypeptide binding]; other site 118163008251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163008252 DNA binding residues [nucleotide binding] 118163008253 dimerization interface [polypeptide binding]; other site 118163008254 Uncharacterized conserved protein [Function unknown]; Region: COG3339 118163008255 Peptidase family M48; Region: Peptidase_M48; cl12018 118163008256 YciI-like protein; Reviewed; Region: PRK12864 118163008257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163008258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008259 active site 118163008260 phosphorylation site [posttranslational modification] 118163008261 intermolecular recognition site; other site 118163008262 dimerization interface [polypeptide binding]; other site 118163008263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163008264 DNA binding site [nucleotide binding] 118163008265 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 118163008266 ATP-NAD kinase; Region: NAD_kinase; pfam01513 118163008267 Ycf39; Provisional; Region: ycf39; CHL00194 118163008268 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 118163008269 NAD(P) binding site [chemical binding]; other site 118163008270 putative active site [active] 118163008271 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 118163008272 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 118163008273 Tetramer interface [polypeptide binding]; other site 118163008274 active site 118163008275 FMN-binding site [chemical binding]; other site 118163008276 elongation factor G; Reviewed; Region: PRK00007 118163008277 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 118163008278 G1 box; other site 118163008279 putative GEF interaction site [polypeptide binding]; other site 118163008280 GTP/Mg2+ binding site [chemical binding]; other site 118163008281 Switch I region; other site 118163008282 G2 box; other site 118163008283 G3 box; other site 118163008284 Switch II region; other site 118163008285 G4 box; other site 118163008286 G5 box; other site 118163008287 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 118163008288 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 118163008289 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 118163008290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008291 binding surface 118163008292 TPR motif; other site 118163008293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008296 binding surface 118163008297 TPR motif; other site 118163008298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008300 binding surface 118163008301 TPR motif; other site 118163008302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008303 CHAT domain; Region: CHAT; pfam12770 118163008304 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 118163008305 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163008306 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 118163008307 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 118163008308 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 118163008309 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 118163008310 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 118163008311 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 118163008312 catalytic motif [active] 118163008313 Zn binding site [ion binding]; other site 118163008314 RibD C-terminal domain; Region: RibD_C; cl17279 118163008315 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 118163008316 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 118163008317 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 118163008318 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163008319 GAF domain; Region: GAF; pfam01590 118163008320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163008322 dimer interface [polypeptide binding]; other site 118163008323 GUN4-like; Region: GUN4; pfam05419 118163008324 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 118163008325 isocitrate dehydrogenase; Validated; Region: PRK07362 118163008326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008327 TPR motif; other site 118163008328 binding surface 118163008329 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163008330 glycogen synthase; Provisional; Region: glgA; PRK00654 118163008331 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 118163008332 ADP-binding pocket [chemical binding]; other site 118163008333 homodimer interface [polypeptide binding]; other site 118163008334 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 118163008335 metal binding site 2 [ion binding]; metal-binding site 118163008336 putative DNA binding helix; other site 118163008337 metal binding site 1 [ion binding]; metal-binding site 118163008338 dimer interface [polypeptide binding]; other site 118163008339 structural Zn2+ binding site [ion binding]; other site 118163008340 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 118163008341 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 118163008342 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 118163008343 putative active site [active] 118163008344 catalytic triad [active] 118163008345 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 118163008346 amphipathic channel; other site 118163008347 Asn-Pro-Ala signature motifs; other site 118163008348 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 118163008349 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 118163008350 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 118163008351 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 118163008352 substrate binding site [chemical binding]; other site 118163008353 hexamer interface [polypeptide binding]; other site 118163008354 metal binding site [ion binding]; metal-binding site 118163008355 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 118163008356 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 118163008357 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 118163008358 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 118163008359 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 118163008360 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 118163008361 P-loop; other site 118163008362 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 118163008363 Rubredoxin; Region: Rubredoxin; pfam00301 118163008364 iron binding site [ion binding]; other site 118163008365 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 118163008366 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 118163008367 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 118163008368 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 118163008369 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 118163008370 trimer interface [polypeptide binding]; other site 118163008371 active site 118163008372 substrate binding site [chemical binding]; other site 118163008373 CoA binding site [chemical binding]; other site 118163008374 Ycf46; Provisional; Region: ycf46; CHL00195 118163008375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163008376 Walker A motif; other site 118163008377 ATP binding site [chemical binding]; other site 118163008378 Walker B motif; other site 118163008379 arginine finger; other site 118163008380 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 118163008381 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 118163008382 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 118163008383 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 118163008384 Cache domain; Region: Cache_1; pfam02743 118163008385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163008387 dimerization interface [polypeptide binding]; other site 118163008388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163008389 dimer interface [polypeptide binding]; other site 118163008390 phosphorylation site [posttranslational modification] 118163008391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008392 ATP binding site [chemical binding]; other site 118163008393 Mg2+ binding site [ion binding]; other site 118163008394 G-X-G motif; other site 118163008395 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163008396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008397 active site 118163008398 phosphorylation site [posttranslational modification] 118163008399 intermolecular recognition site; other site 118163008400 dimerization interface [polypeptide binding]; other site 118163008401 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008403 active site 118163008404 phosphorylation site [posttranslational modification] 118163008405 intermolecular recognition site; other site 118163008406 dimerization interface [polypeptide binding]; other site 118163008407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163008408 dimer interface [polypeptide binding]; other site 118163008409 phosphorylation site [posttranslational modification] 118163008410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008412 ATP binding site [chemical binding]; other site 118163008413 Mg2+ binding site [ion binding]; other site 118163008414 G-X-G motif; other site 118163008415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163008416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008417 active site 118163008418 phosphorylation site [posttranslational modification] 118163008419 intermolecular recognition site; other site 118163008420 dimerization interface [polypeptide binding]; other site 118163008421 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008423 active site 118163008424 phosphorylation site [posttranslational modification] 118163008425 intermolecular recognition site; other site 118163008426 dimerization interface [polypeptide binding]; other site 118163008427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163008428 PAS fold; Region: PAS_3; pfam08447 118163008429 putative active site [active] 118163008430 heme pocket [chemical binding]; other site 118163008431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163008432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163008433 metal binding site [ion binding]; metal-binding site 118163008434 active site 118163008435 I-site; other site 118163008436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163008437 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 118163008438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163008439 motif II; other site 118163008440 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 118163008441 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 118163008442 acyl-activating enzyme (AAE) consensus motif; other site 118163008443 putative AMP binding site [chemical binding]; other site 118163008444 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 118163008445 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 118163008446 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163008447 active site 118163008448 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 118163008449 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 118163008450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163008451 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 118163008452 Enoylreductase; Region: PKS_ER; smart00829 118163008453 NAD(P) binding site [chemical binding]; other site 118163008454 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 118163008455 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 118163008456 putative NADP binding site [chemical binding]; other site 118163008457 active site 118163008458 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163008459 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 118163008460 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 118163008461 Walker A/P-loop; other site 118163008462 ATP binding site [chemical binding]; other site 118163008463 Q-loop/lid; other site 118163008464 ABC transporter signature motif; other site 118163008465 Walker B; other site 118163008466 D-loop; other site 118163008467 H-loop/switch region; other site 118163008468 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 118163008469 putative hexamer interface [polypeptide binding]; other site 118163008470 putative hexagonal pore; other site 118163008471 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 118163008472 putative hexamer interface [polypeptide binding]; other site 118163008473 putative hexagonal pore; other site 118163008474 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 118163008475 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 118163008476 RNA binding site [nucleotide binding]; other site 118163008477 active site 118163008478 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 118163008479 Transglycosylase; Region: Transgly; pfam00912 118163008480 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 118163008481 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 118163008482 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 118163008483 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 118163008484 active site 118163008485 HIGH motif; other site 118163008486 dimer interface [polypeptide binding]; other site 118163008487 KMSKS motif; other site 118163008488 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008490 active site 118163008491 phosphorylation site [posttranslational modification] 118163008492 intermolecular recognition site; other site 118163008493 dimerization interface [polypeptide binding]; other site 118163008494 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163008495 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163008496 metal binding site [ion binding]; metal-binding site 118163008497 active site 118163008498 I-site; other site 118163008499 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163008500 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 118163008501 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 118163008502 E3 interaction surface; other site 118163008503 lipoyl attachment site [posttranslational modification]; other site 118163008504 e3 binding domain; Region: E3_binding; pfam02817 118163008505 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 118163008506 GH3 auxin-responsive promoter; Region: GH3; pfam03321 118163008507 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163008508 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 118163008509 acetate--CoA ligase; Provisional; Region: PLN03052 118163008510 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 118163008511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163008512 acyl-activating enzyme (AAE) consensus motif; other site 118163008513 AMP binding site [chemical binding]; other site 118163008514 active site 118163008515 CoA binding site [chemical binding]; other site 118163008516 Biofilm formation and stress response factor; Region: BsmA; cl01794 118163008517 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 118163008518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163008519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163008520 catalytic residue [active] 118163008521 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 118163008522 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 118163008523 active site 118163008524 homodimer interface [polypeptide binding]; other site 118163008525 catalytic site [active] 118163008526 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 118163008527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163008528 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 118163008529 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 118163008530 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 118163008531 aspartate aminotransferase; Provisional; Region: PRK05942 118163008532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163008533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163008534 homodimer interface [polypeptide binding]; other site 118163008535 catalytic residue [active] 118163008536 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 118163008537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 118163008538 active site 118163008539 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 118163008540 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 118163008541 four helix bundle protein; Region: TIGR02436 118163008542 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 118163008543 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 118163008544 dimer interface [polypeptide binding]; other site 118163008545 active site 118163008546 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 118163008547 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 118163008548 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 118163008549 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 118163008550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 118163008551 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 118163008552 substrate binding site [chemical binding]; other site 118163008553 oxyanion hole (OAH) forming residues; other site 118163008554 trimer interface [polypeptide binding]; other site 118163008555 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 118163008556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163008557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163008558 acyl-activating enzyme (AAE) consensus motif; other site 118163008559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163008560 AMP binding site [chemical binding]; other site 118163008561 active site 118163008562 CoA binding site [chemical binding]; other site 118163008563 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 118163008564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163008565 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 118163008566 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 118163008567 putative di-iron ligands [ion binding]; other site 118163008568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163008569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163008570 active site 118163008571 catalytic tetrad [active] 118163008572 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 118163008573 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163008574 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163008575 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 118163008576 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 118163008577 NAD binding site [chemical binding]; other site 118163008578 dimer interface [polypeptide binding]; other site 118163008579 substrate binding site [chemical binding]; other site 118163008580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 118163008581 dihydroorotase; Provisional; Region: PRK07575 118163008582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 118163008583 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 118163008584 active site 118163008585 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 118163008586 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 118163008587 Catalytic site [active] 118163008588 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 118163008589 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 118163008590 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163008591 active site 118163008592 AAA domain; Region: AAA_26; pfam13500 118163008593 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 118163008594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008595 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 118163008596 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 118163008597 substrate binding site [chemical binding]; other site 118163008598 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 118163008599 homodimer interface [polypeptide binding]; other site 118163008600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163008601 catalytic residue [active] 118163008602 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 118163008603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163008604 putative ADP-binding pocket [chemical binding]; other site 118163008605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163008606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163008607 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008609 active site 118163008610 phosphorylation site [posttranslational modification] 118163008611 intermolecular recognition site; other site 118163008612 dimerization interface [polypeptide binding]; other site 118163008613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 118163008614 Histidine kinase; Region: HisKA_3; pfam07730 118163008615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008616 ATP binding site [chemical binding]; other site 118163008617 Mg2+ binding site [ion binding]; other site 118163008618 G-X-G motif; other site 118163008619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163008620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008621 active site 118163008622 phosphorylation site [posttranslational modification] 118163008623 intermolecular recognition site; other site 118163008624 dimerization interface [polypeptide binding]; other site 118163008625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163008626 DNA binding residues [nucleotide binding] 118163008627 dimerization interface [polypeptide binding]; other site 118163008628 D5 N terminal like; Region: D5_N; cl07360 118163008629 ribosome maturation protein RimP; Reviewed; Region: PRK00092 118163008630 Sm and related proteins; Region: Sm_like; cl00259 118163008631 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 118163008632 putative oligomer interface [polypeptide binding]; other site 118163008633 putative RNA binding site [nucleotide binding]; other site 118163008634 NusA N-terminal domain; Region: NusA_N; pfam08529 118163008635 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 118163008636 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 118163008637 RNA binding site [nucleotide binding]; other site 118163008638 homodimer interface [polypeptide binding]; other site 118163008639 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 118163008640 G-X-X-G motif; other site 118163008641 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 118163008642 G-X-X-G motif; other site 118163008643 Protein of unknown function (DUF448); Region: DUF448; pfam04296 118163008644 putative RNA binding cleft [nucleotide binding]; other site 118163008645 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 118163008646 translation initiation factor IF-2; Region: IF-2; TIGR00487 118163008647 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 118163008648 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 118163008649 G1 box; other site 118163008650 putative GEF interaction site [polypeptide binding]; other site 118163008651 GTP/Mg2+ binding site [chemical binding]; other site 118163008652 Switch I region; other site 118163008653 G2 box; other site 118163008654 G3 box; other site 118163008655 Switch II region; other site 118163008656 G4 box; other site 118163008657 G5 box; other site 118163008658 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 118163008659 Translation-initiation factor 2; Region: IF-2; pfam11987 118163008660 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 118163008661 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008663 active site 118163008664 phosphorylation site [posttranslational modification] 118163008665 intermolecular recognition site; other site 118163008666 dimerization interface [polypeptide binding]; other site 118163008667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163008668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 118163008669 dimer interface [polypeptide binding]; other site 118163008670 phosphorylation site [posttranslational modification] 118163008671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008672 ATP binding site [chemical binding]; other site 118163008673 Mg2+ binding site [ion binding]; other site 118163008674 G-X-G motif; other site 118163008675 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 118163008676 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 118163008677 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163008678 ligand binding site [chemical binding]; other site 118163008679 flexible hinge region; other site 118163008680 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 118163008681 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 118163008682 putative active site [active] 118163008683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163008684 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 118163008685 Walker A/P-loop; other site 118163008686 ATP binding site [chemical binding]; other site 118163008687 Q-loop/lid; other site 118163008688 ABC transporter signature motif; other site 118163008689 Walker B; other site 118163008690 D-loop; other site 118163008691 H-loop/switch region; other site 118163008692 HlyD family secretion protein; Region: HlyD; pfam00529 118163008693 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 118163008694 E3 interaction surface; other site 118163008695 lipoyl attachment site [posttranslational modification]; other site 118163008696 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163008697 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 118163008698 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 118163008699 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 118163008700 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 118163008701 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 118163008702 NAD binding site [chemical binding]; other site 118163008703 homodimer interface [polypeptide binding]; other site 118163008704 active site 118163008705 substrate binding site [chemical binding]; other site 118163008706 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 118163008707 putative homodimer interface [polypeptide binding]; other site 118163008708 putative homotetramer interface [polypeptide binding]; other site 118163008709 putative metal binding site [ion binding]; other site 118163008710 putative homodimer-homodimer interface [polypeptide binding]; other site 118163008711 putative allosteric switch controlling residues; other site 118163008712 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 118163008713 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 118163008714 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 118163008715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163008716 catalytic residue [active] 118163008717 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 118163008718 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 118163008719 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 118163008720 shikimate binding site; other site 118163008721 NAD(P) binding site [chemical binding]; other site 118163008722 yiaA/B two helix domain; Region: YiaAB; cl01759 118163008723 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 118163008724 Ycf35; Provisional; Region: ycf35; CHL00193 118163008725 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 118163008726 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 118163008727 NAD(P) binding pocket [chemical binding]; other site 118163008728 Protein of unknown function, DUF479; Region: DUF479; cl01203 118163008729 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 118163008730 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 118163008731 putative di-iron ligands [ion binding]; other site 118163008732 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 118163008733 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 118163008734 quinone interaction residues [chemical binding]; other site 118163008735 active site 118163008736 catalytic residues [active] 118163008737 FMN binding site [chemical binding]; other site 118163008738 substrate binding site [chemical binding]; other site 118163008739 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 118163008740 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163008741 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 118163008742 Cytochrome c; Region: Cytochrom_C; pfam00034 118163008743 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 118163008744 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 118163008745 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 118163008746 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 118163008747 phosphate binding site [ion binding]; other site 118163008748 putative substrate binding pocket [chemical binding]; other site 118163008749 dimer interface [polypeptide binding]; other site 118163008750 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 118163008751 active site 118163008752 putative DNA-binding cleft [nucleotide binding]; other site 118163008753 dimer interface [polypeptide binding]; other site 118163008754 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163008755 HSP70 interaction site [polypeptide binding]; other site 118163008756 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 118163008757 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 118163008758 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 118163008759 tetramer interface [polypeptide binding]; other site 118163008760 TPP-binding site [chemical binding]; other site 118163008761 heterodimer interface [polypeptide binding]; other site 118163008762 phosphorylation loop region [posttranslational modification] 118163008763 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 118163008764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 118163008765 ATP binding site [chemical binding]; other site 118163008766 putative Mg++ binding site [ion binding]; other site 118163008767 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 118163008768 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 118163008769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163008770 dimerization interface [polypeptide binding]; other site 118163008771 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 118163008772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 118163008773 membrane-bound complex binding site; other site 118163008774 hinge residues; other site 118163008775 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 118163008776 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 118163008777 putative dimer interface [polypeptide binding]; other site 118163008778 GTP-binding protein YchF; Reviewed; Region: PRK09601 118163008779 YchF GTPase; Region: YchF; cd01900 118163008780 G1 box; other site 118163008781 GTP/Mg2+ binding site [chemical binding]; other site 118163008782 Switch I region; other site 118163008783 G2 box; other site 118163008784 Switch II region; other site 118163008785 G3 box; other site 118163008786 G4 box; other site 118163008787 G5 box; other site 118163008788 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 118163008789 Spherulation-specific family 4; Region: Spherulin4; pfam12138 118163008790 Haemolysin XhlA; Region: XhlA; pfam10779 118163008791 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 118163008792 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 118163008793 NAD binding site [chemical binding]; other site 118163008794 homodimer interface [polypeptide binding]; other site 118163008795 active site 118163008796 substrate binding site [chemical binding]; other site 118163008797 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 118163008798 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 118163008799 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 118163008800 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 118163008801 active site 118163008802 substrate binding site [chemical binding]; other site 118163008803 metal binding site [ion binding]; metal-binding site 118163008804 Response regulator receiver domain; Region: Response_reg; pfam00072 118163008805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163008806 active site 118163008807 phosphorylation site [posttranslational modification] 118163008808 intermolecular recognition site; other site 118163008809 dimerization interface [polypeptide binding]; other site 118163008810 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 118163008811 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163008812 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163008813 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163008814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163008815 methionine sulfoxide reductase A; Provisional; Region: PRK13014 118163008816 geranylgeranyl reductase; Region: ChlP; TIGR02028 118163008817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163008818 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 118163008819 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163008820 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 118163008821 Walker A/P-loop; other site 118163008822 ATP binding site [chemical binding]; other site 118163008823 Q-loop/lid; other site 118163008824 ABC transporter signature motif; other site 118163008825 Walker B; other site 118163008826 D-loop; other site 118163008827 H-loop/switch region; other site 118163008828 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163008829 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 118163008830 Walker A/P-loop; other site 118163008831 ATP binding site [chemical binding]; other site 118163008832 Q-loop/lid; other site 118163008833 ABC transporter signature motif; other site 118163008834 Walker B; other site 118163008835 D-loop; other site 118163008836 H-loop/switch region; other site 118163008837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 118163008838 NMT1-like family; Region: NMT1_2; pfam13379 118163008839 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 118163008840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163008841 dimer interface [polypeptide binding]; other site 118163008842 conserved gate region; other site 118163008843 putative PBP binding loops; other site 118163008844 ABC-ATPase subunit interface; other site 118163008845 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 118163008846 NMT1-like family; Region: NMT1_2; pfam13379 118163008847 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 118163008848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163008849 Mg2+ binding site [ion binding]; other site 118163008850 G-X-G motif; other site 118163008851 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 118163008852 anchoring element; other site 118163008853 dimer interface [polypeptide binding]; other site 118163008854 ATP binding site [chemical binding]; other site 118163008855 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 118163008856 active site 118163008857 putative metal-binding site [ion binding]; other site 118163008858 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 118163008859 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 118163008860 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 118163008861 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 118163008862 ScpA/B protein; Region: ScpA_ScpB; pfam02616 118163008863 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 118163008864 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 118163008865 active site 118163008866 Substrate binding site; other site 118163008867 Mg++ binding site; other site 118163008868 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 118163008869 putative trimer interface [polypeptide binding]; other site 118163008870 putative CoA binding site [chemical binding]; other site 118163008871 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 118163008872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163008873 active site 118163008874 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 118163008875 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 118163008876 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 118163008877 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 118163008878 ResB-like family; Region: ResB; pfam05140 118163008879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 118163008880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163008881 Coenzyme A binding pocket [chemical binding]; other site 118163008882 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 118163008883 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 118163008884 Walker A/P-loop; other site 118163008885 ATP binding site [chemical binding]; other site 118163008886 Q-loop/lid; other site 118163008887 ABC transporter signature motif; other site 118163008888 Walker B; other site 118163008889 D-loop; other site 118163008890 H-loop/switch region; other site 118163008891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163008892 dimer interface [polypeptide binding]; other site 118163008893 ABC-ATPase subunit interface; other site 118163008894 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 118163008895 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 118163008896 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163008898 binding surface 118163008899 TPR motif; other site 118163008900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163008901 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 118163008902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163008903 FeS/SAM binding site; other site 118163008904 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 118163008905 Ligand Binding Site [chemical binding]; other site 118163008906 homoserine kinase; Provisional; Region: PRK01212 118163008907 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 118163008908 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 118163008909 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 118163008910 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 118163008911 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 118163008912 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 118163008913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163008914 Walker A motif; other site 118163008915 ATP binding site [chemical binding]; other site 118163008916 Walker B motif; other site 118163008917 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 118163008918 RxxxH motif; other site 118163008919 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 118163008920 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 118163008921 putative NAD(P) binding site [chemical binding]; other site 118163008922 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 118163008923 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 118163008924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163008925 active site 118163008926 motif I; other site 118163008927 motif II; other site 118163008928 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 118163008929 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 118163008930 putative active site [active] 118163008931 catalytic triad [active] 118163008932 putative dimer interface [polypeptide binding]; other site 118163008933 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 118163008934 DNA photolyase; Region: DNA_photolyase; pfam00875 118163008935 ferredoxin-sulfite reductase; Region: sir; TIGR02042 118163008936 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 118163008937 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 118163008938 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 118163008939 RuvA N terminal domain; Region: RuvA_N; pfam01330 118163008940 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 118163008941 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 118163008942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 118163008943 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 118163008944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163008945 S-adenosylmethionine binding site [chemical binding]; other site 118163008946 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 118163008947 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 118163008948 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 118163008949 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 118163008950 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 118163008951 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 118163008952 ligand binding site; other site 118163008953 oligomer interface; other site 118163008954 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 118163008955 dimer interface [polypeptide binding]; other site 118163008956 N-terminal domain interface [polypeptide binding]; other site 118163008957 sulfate 1 binding site; other site 118163008958 lipoyl synthase; Provisional; Region: PRK05481 118163008959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163008960 FeS/SAM binding site; other site 118163008961 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 118163008962 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 118163008963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163008964 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163008965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163008966 DNA binding residues [nucleotide binding] 118163008967 2TM domain; Region: 2TM; pfam13239 118163008968 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 118163008969 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 118163008970 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 118163008971 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 118163008972 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 118163008973 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 118163008974 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 118163008975 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 118163008976 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 118163008977 RNase E interface [polypeptide binding]; other site 118163008978 trimer interface [polypeptide binding]; other site 118163008979 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 118163008980 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 118163008981 RNase E interface [polypeptide binding]; other site 118163008982 trimer interface [polypeptide binding]; other site 118163008983 active site 118163008984 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 118163008985 putative nucleic acid binding region [nucleotide binding]; other site 118163008986 G-X-X-G motif; other site 118163008987 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 118163008988 RNA binding site [nucleotide binding]; other site 118163008989 domain interface; other site 118163008990 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 118163008991 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 118163008992 active site 118163008993 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 118163008994 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 118163008995 PilZ domain; Region: PilZ; pfam07238 118163008996 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 118163008997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 118163008998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 118163008999 active site residue [active] 118163009000 Protein of unknown function, DUF547; Region: DUF547; pfam04784 118163009001 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 118163009002 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 118163009003 Probable Catalytic site; other site 118163009004 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163009005 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163009006 Hexamer interface [polypeptide binding]; other site 118163009007 Hexagonal pore residue; other site 118163009008 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163009009 Hexamer interface [polypeptide binding]; other site 118163009010 Hexagonal pore residue; other site 118163009011 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 118163009012 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 118163009013 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 118163009014 homodimer interface [polypeptide binding]; other site 118163009015 Walker A motif; other site 118163009016 ATP binding site [chemical binding]; other site 118163009017 hydroxycobalamin binding site [chemical binding]; other site 118163009018 Walker B motif; other site 118163009019 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163009020 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 118163009021 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 118163009022 threonine synthase; Validated; Region: PRK07591 118163009023 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 118163009024 homodimer interface [polypeptide binding]; other site 118163009025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009026 catalytic residue [active] 118163009027 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 118163009028 MoaE interaction surface [polypeptide binding]; other site 118163009029 MoeB interaction surface [polypeptide binding]; other site 118163009030 thiocarboxylated glycine; other site 118163009031 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163009032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163009033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163009034 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 118163009035 active site 118163009036 Acyl transferase domain; Region: Acyl_transf_1; cl08282 118163009037 Acyl transferase domain; Region: Acyl_transf_1; cl08282 118163009038 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 118163009039 hydrophobic ligand binding site; other site 118163009040 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 118163009041 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 118163009042 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 118163009043 putative active site [active] 118163009044 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 118163009045 Peptidase family M50; Region: Peptidase_M50; pfam02163 118163009046 active site 118163009047 putative substrate binding region [chemical binding]; other site 118163009048 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 118163009049 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163009050 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163009051 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 118163009052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163009053 Response regulator receiver domain; Region: Response_reg; pfam00072 118163009054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009055 active site 118163009056 phosphorylation site [posttranslational modification] 118163009057 intermolecular recognition site; other site 118163009058 dimerization interface [polypeptide binding]; other site 118163009059 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163009060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163009061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163009062 Walker A/P-loop; other site 118163009063 ATP binding site [chemical binding]; other site 118163009064 Q-loop/lid; other site 118163009065 ABC transporter signature motif; other site 118163009066 Walker B; other site 118163009067 D-loop; other site 118163009068 H-loop/switch region; other site 118163009069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163009070 catalytic core [active] 118163009071 citrate synthase; Provisional; Region: PRK14036 118163009072 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 118163009073 oxalacetate binding site [chemical binding]; other site 118163009074 citrylCoA binding site [chemical binding]; other site 118163009075 coenzyme A binding site [chemical binding]; other site 118163009076 catalytic triad [active] 118163009077 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 118163009078 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163009079 Predicted permeases [General function prediction only]; Region: COG0701 118163009080 ferrochelatase; Reviewed; Region: hemH; PRK00035 118163009081 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 118163009082 active site 118163009083 C-terminal domain interface [polypeptide binding]; other site 118163009084 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 118163009085 active site 118163009086 N-terminal domain interface [polypeptide binding]; other site 118163009087 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 118163009088 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 118163009089 KH domain; Region: KH_4; pfam13083 118163009090 ribosomal protein S16; Region: rps16; CHL00005 118163009091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163009092 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 118163009093 putative NAD(P) binding site [chemical binding]; other site 118163009094 active site 118163009095 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 118163009096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163009097 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 118163009098 acyl-CoA synthetase; Validated; Region: PRK05850 118163009099 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163009100 acyl-activating enzyme (AAE) consensus motif; other site 118163009101 active site 118163009102 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 118163009103 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 118163009104 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 118163009105 putative ADP-binding pocket [chemical binding]; other site 118163009106 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 118163009107 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 118163009108 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 118163009109 C-terminal peptidase (prc); Region: prc; TIGR00225 118163009110 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 118163009111 protein binding site [polypeptide binding]; other site 118163009112 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 118163009113 Catalytic dyad [active] 118163009114 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 118163009115 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 118163009116 rod shape-determining protein MreC; Provisional; Region: PRK13922 118163009117 rod shape-determining protein MreC; Region: MreC; pfam04085 118163009118 rod shape-determining protein MreB; Provisional; Region: PRK13927 118163009119 MreB and similar proteins; Region: MreB_like; cd10225 118163009120 nucleotide binding site [chemical binding]; other site 118163009121 Mg binding site [ion binding]; other site 118163009122 putative protofilament interaction site [polypeptide binding]; other site 118163009123 RodZ interaction site [polypeptide binding]; other site 118163009124 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 118163009125 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 118163009126 dimer interface [polypeptide binding]; other site 118163009127 ssDNA binding site [nucleotide binding]; other site 118163009128 tetramer (dimer of dimers) interface [polypeptide binding]; other site 118163009129 Uncharacterized conserved protein [Function unknown]; Region: COG2968 118163009130 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 118163009131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163009132 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 118163009133 putative ADP-binding pocket [chemical binding]; other site 118163009134 Bacterial sugar transferase; Region: Bac_transf; pfam02397 118163009135 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 118163009136 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 118163009137 NADP-binding site; other site 118163009138 homotetramer interface [polypeptide binding]; other site 118163009139 substrate binding site [chemical binding]; other site 118163009140 homodimer interface [polypeptide binding]; other site 118163009141 active site 118163009142 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 118163009143 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 118163009144 NADP binding site [chemical binding]; other site 118163009145 active site 118163009146 putative substrate binding site [chemical binding]; other site 118163009147 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 118163009148 ATP-binding site [chemical binding]; other site 118163009149 Gluconate-6-phosphate binding site [chemical binding]; other site 118163009150 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 118163009151 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 118163009152 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163009153 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 118163009154 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 118163009155 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 118163009156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 118163009157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 118163009158 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 118163009159 putative dimerization interface [polypeptide binding]; other site 118163009160 DNA repair protein RadA; Provisional; Region: PRK11823 118163009161 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 118163009162 Walker A motif/ATP binding site; other site 118163009163 ATP binding site [chemical binding]; other site 118163009164 Walker B motif; other site 118163009165 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 118163009166 Ycf27; Reviewed; Region: orf27; CHL00148 118163009167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009168 active site 118163009169 phosphorylation site [posttranslational modification] 118163009170 intermolecular recognition site; other site 118163009171 dimerization interface [polypeptide binding]; other site 118163009172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163009173 DNA binding site [nucleotide binding] 118163009174 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 118163009175 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 118163009176 putative active site pocket [active] 118163009177 dimerization interface [polypeptide binding]; other site 118163009178 putative catalytic residue [active] 118163009179 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 118163009180 active site 118163009181 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 118163009182 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 118163009183 active site 118163009184 Zn2+ binding site [ion binding]; other site 118163009185 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 118163009186 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 118163009187 putative ligand binding site [chemical binding]; other site 118163009188 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 118163009189 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 118163009190 Cytochrome c; Region: Cytochrom_C; cl11414 118163009191 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 118163009192 plastocyanin; Provisional; Region: PRK02710 118163009193 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 118163009194 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 118163009195 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 118163009196 nucleotide binding pocket [chemical binding]; other site 118163009197 K-X-D-G motif; other site 118163009198 catalytic site [active] 118163009199 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 118163009200 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 118163009201 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 118163009202 Dimer interface [polypeptide binding]; other site 118163009203 BRCT sequence motif; other site 118163009204 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 118163009205 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 118163009206 putative active site pocket [active] 118163009207 4-fold oligomerization interface [polypeptide binding]; other site 118163009208 metal binding residues [ion binding]; metal-binding site 118163009209 3-fold/trimer interface [polypeptide binding]; other site 118163009210 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 118163009211 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 118163009212 Peptidase family M23; Region: Peptidase_M23; pfam01551 118163009213 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 118163009214 Lumazine binding domain; Region: Lum_binding; pfam00677 118163009215 Lumazine binding domain; Region: Lum_binding; pfam00677 118163009216 Bifunctional nuclease; Region: DNase-RNase; pfam02577 118163009217 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 118163009218 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163009219 active site 118163009220 catalytic tetrad [active] 118163009221 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 118163009222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163009223 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 118163009224 non-specific DNA interactions [nucleotide binding]; other site 118163009225 DNA binding site [nucleotide binding] 118163009226 sequence specific DNA binding site [nucleotide binding]; other site 118163009227 putative cAMP binding site [chemical binding]; other site 118163009228 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 118163009229 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 118163009230 HIGH motif; other site 118163009231 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 118163009232 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 118163009233 active site 118163009234 KMSKS motif; other site 118163009235 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 118163009236 tRNA binding surface [nucleotide binding]; other site 118163009237 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 118163009238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163009239 S-adenosylmethionine binding site [chemical binding]; other site 118163009240 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 118163009241 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 118163009242 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 118163009243 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 118163009244 substrate binding site [chemical binding]; other site 118163009245 active site 118163009246 catalytic residues [active] 118163009247 heterodimer interface [polypeptide binding]; other site 118163009248 TPR repeat; Region: TPR_11; pfam13414 118163009249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009250 binding surface 118163009251 TPR motif; other site 118163009252 TPR repeat; Region: TPR_11; pfam13414 118163009253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009254 binding surface 118163009255 Tetratricopeptide repeat; Region: TPR_16; pfam13432 118163009256 TPR motif; other site 118163009257 TPR repeat; Region: TPR_11; pfam13414 118163009258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009259 binding surface 118163009260 TPR motif; other site 118163009261 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 118163009262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163009263 Probable transposase; Region: OrfB_IS605; pfam01385 118163009264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163009265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009266 active site 118163009267 phosphorylation site [posttranslational modification] 118163009268 intermolecular recognition site; other site 118163009269 dimerization interface [polypeptide binding]; other site 118163009270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163009271 DNA binding site [nucleotide binding] 118163009272 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 118163009273 AAA ATPase domain; Region: AAA_16; pfam13191 118163009274 AAA domain; Region: AAA_23; pfam13476 118163009275 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163009276 structural tetrad; other site 118163009277 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163009278 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163009279 structural tetrad; other site 118163009280 TPR repeat; Region: TPR_11; pfam13414 118163009281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009282 binding surface 118163009283 TPR motif; other site 118163009284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 118163009285 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163009286 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009288 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009289 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009290 biotin synthase; Validated; Region: PRK06256 118163009291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163009292 FeS/SAM binding site; other site 118163009293 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 118163009294 Beta-propeller repeat; Region: SBBP; pfam06739 118163009295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163009296 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 118163009297 catalytic site [active] 118163009298 Uncharacterized conserved protein [Function unknown]; Region: COG1359 118163009299 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 118163009300 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 118163009301 HflK protein; Region: hflK; TIGR01933 118163009302 putative addiction module antidote; Region: doc_partner; TIGR02609 118163009303 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 118163009304 magnesium chelatase subunit H; Provisional; Region: PLN03241 118163009305 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163009306 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163009307 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 118163009308 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 118163009309 cobalamin synthase; Reviewed; Region: cobS; PRK00235 118163009310 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 118163009311 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 118163009312 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 118163009313 Walker A/P-loop; other site 118163009314 ATP binding site [chemical binding]; other site 118163009315 Q-loop/lid; other site 118163009316 ABC transporter signature motif; other site 118163009317 Walker B; other site 118163009318 D-loop; other site 118163009319 H-loop/switch region; other site 118163009320 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 118163009321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163009322 dimer interface [polypeptide binding]; other site 118163009323 conserved gate region; other site 118163009324 putative PBP binding loops; other site 118163009325 ABC-ATPase subunit interface; other site 118163009326 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 118163009327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163009328 dimer interface [polypeptide binding]; other site 118163009329 conserved gate region; other site 118163009330 putative PBP binding loops; other site 118163009331 ABC-ATPase subunit interface; other site 118163009332 PBP superfamily domain; Region: PBP_like_2; cl17296 118163009333 PBP superfamily domain; Region: PBP_like_2; cl17296 118163009334 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 118163009335 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 118163009336 substrate-cofactor binding pocket; other site 118163009337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009338 catalytic residue [active] 118163009339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 118163009340 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 118163009341 active site 118163009342 metal binding site [ion binding]; metal-binding site 118163009343 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163009344 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163009345 structural tetrad; other site 118163009346 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 118163009347 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 118163009348 putative dimer interface [polypeptide binding]; other site 118163009349 putative anticodon binding site; other site 118163009350 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 118163009351 homodimer interface [polypeptide binding]; other site 118163009352 motif 1; other site 118163009353 motif 2; other site 118163009354 active site 118163009355 motif 3; other site 118163009356 light-harvesting-like protein 3; Provisional; Region: PLN00014 118163009357 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 118163009358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163009359 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163009360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163009361 DNA binding residues [nucleotide binding] 118163009362 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 118163009363 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 118163009364 NodB motif; other site 118163009365 active site 118163009366 catalytic site [active] 118163009367 metal binding site [ion binding]; metal-binding site 118163009368 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 118163009369 CHAT domain; Region: CHAT; cl17868 118163009370 Protein of function (DUF2518); Region: DUF2518; pfam10726 118163009371 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 118163009372 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 118163009373 putative active site [active] 118163009374 metal binding site [ion binding]; metal-binding site 118163009375 DevC protein; Region: devC; TIGR01185 118163009376 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163009377 FtsX-like permease family; Region: FtsX; pfam02687 118163009378 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 118163009379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 118163009380 Walker A/P-loop; other site 118163009381 ATP binding site [chemical binding]; other site 118163009382 Q-loop/lid; other site 118163009383 ABC transporter signature motif; other site 118163009384 Walker B; other site 118163009385 D-loop; other site 118163009386 H-loop/switch region; other site 118163009387 CpeS-like protein; Region: CpeS; pfam09367 118163009388 Phycobilisome protein; Region: Phycobilisome; cl08227 118163009389 HEAT repeats; Region: HEAT_2; pfam13646 118163009390 HEAT repeats; Region: HEAT_2; pfam13646 118163009391 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 118163009392 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 118163009393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163009394 motif II; other site 118163009395 magnesium chelatase subunit H; Provisional; Region: PRK12493 118163009396 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 118163009397 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163009398 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 118163009399 TPR repeat; Region: TPR_11; pfam13414 118163009400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009401 binding surface 118163009402 TPR motif; other site 118163009403 TPR repeat; Region: TPR_11; pfam13414 118163009404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009405 binding surface 118163009406 TPR motif; other site 118163009407 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 118163009408 active site 118163009409 S-layer homology domain; Region: SLH; pfam00395 118163009410 S-layer homology domain; Region: SLH; pfam00395 118163009411 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 118163009412 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 118163009413 B12 binding site [chemical binding]; other site 118163009414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163009415 FeS/SAM binding site; other site 118163009416 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 118163009417 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 118163009418 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 118163009419 DHH family; Region: DHH; pfam01368 118163009420 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163009421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163009422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163009423 protein binding site [polypeptide binding]; other site 118163009424 Uncharacterized protein involved in cysteine biosynthesis [Amino acid transport and metabolism]; Region: CysZ; COG2981 118163009425 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 118163009426 Predicted transcriptional regulator [Transcription]; Region: COG3682 118163009427 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 118163009428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 118163009429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163009430 putative substrate translocation pore; other site 118163009431 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 118163009432 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 118163009433 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 118163009434 metal binding site [ion binding]; metal-binding site 118163009435 cytochrome c-550; Provisional; Region: psbV; PRK13619 118163009436 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 118163009437 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 118163009438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163009439 dimer interface [polypeptide binding]; other site 118163009440 ABC-ATPase subunit interface; other site 118163009441 putative PBP binding loops; other site 118163009442 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 118163009443 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 118163009444 inhibitor-cofactor binding pocket; inhibition site 118163009445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009446 catalytic residue [active] 118163009447 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 118163009448 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 118163009449 chaperone protein DnaJ; Provisional; Region: PRK14299 118163009450 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163009451 HSP70 interaction site [polypeptide binding]; other site 118163009452 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 118163009453 substrate binding site [polypeptide binding]; other site 118163009454 dimer interface [polypeptide binding]; other site 118163009455 Predicted membrane protein [Function unknown]; Region: COG1971 118163009456 Domain of unknown function DUF; Region: DUF204; pfam02659 118163009457 Thf1-like protein; Reviewed; Region: PRK13266 118163009458 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 118163009459 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 118163009460 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 118163009461 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 118163009462 glutaminase active site [active] 118163009463 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 118163009464 dimer interface [polypeptide binding]; other site 118163009465 active site 118163009466 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 118163009467 dimer interface [polypeptide binding]; other site 118163009468 active site 118163009469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163009470 ligand binding site [chemical binding]; other site 118163009471 flexible hinge region; other site 118163009472 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 118163009473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163009474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163009475 Walker A/P-loop; other site 118163009476 ATP binding site [chemical binding]; other site 118163009477 Q-loop/lid; other site 118163009478 ABC transporter signature motif; other site 118163009479 Walker B; other site 118163009480 D-loop; other site 118163009481 H-loop/switch region; other site 118163009482 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 118163009483 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 118163009484 putative active site [active] 118163009485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163009486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163009487 Walker A/P-loop; other site 118163009488 ATP binding site [chemical binding]; other site 118163009489 Q-loop/lid; other site 118163009490 ABC transporter signature motif; other site 118163009491 Walker B; other site 118163009492 D-loop; other site 118163009493 H-loop/switch region; other site 118163009494 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 118163009495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163009496 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163009497 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163009498 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 118163009499 ligand binding site [chemical binding]; other site 118163009500 flexible hinge region; other site 118163009501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163009502 ligand binding site [chemical binding]; other site 118163009503 flexible hinge region; other site 118163009504 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163009505 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 118163009506 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 118163009507 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 118163009508 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 118163009509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163009510 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 118163009511 HAMP domain; Region: HAMP; pfam00672 118163009512 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 118163009513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163009514 HAMP domain; Region: HAMP; pfam00672 118163009515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163009516 dimer interface [polypeptide binding]; other site 118163009517 phosphorylation site [posttranslational modification] 118163009518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163009519 ATP binding site [chemical binding]; other site 118163009520 Mg2+ binding site [ion binding]; other site 118163009521 G-X-G motif; other site 118163009522 Response regulator receiver domain; Region: Response_reg; pfam00072 118163009523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009524 active site 118163009525 phosphorylation site [posttranslational modification] 118163009526 intermolecular recognition site; other site 118163009527 dimerization interface [polypeptide binding]; other site 118163009528 Cache domain; Region: Cache_1; pfam02743 118163009529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 118163009530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 118163009531 dimerization interface [polypeptide binding]; other site 118163009532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163009533 putative active site [active] 118163009534 heme pocket [chemical binding]; other site 118163009535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163009536 dimer interface [polypeptide binding]; other site 118163009537 phosphorylation site [posttranslational modification] 118163009538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163009539 ATP binding site [chemical binding]; other site 118163009540 Mg2+ binding site [ion binding]; other site 118163009541 G-X-G motif; other site 118163009542 Response regulator receiver domain; Region: Response_reg; pfam00072 118163009543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009544 active site 118163009545 phosphorylation site [posttranslational modification] 118163009546 intermolecular recognition site; other site 118163009547 dimerization interface [polypeptide binding]; other site 118163009548 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 118163009549 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 118163009550 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 118163009551 OstA-like protein; Region: OstA; cl00844 118163009552 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 118163009553 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 118163009554 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 118163009555 ribosomal protein L23; Region: rpl23; CHL00030 118163009556 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 118163009557 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 118163009558 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 118163009559 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 118163009560 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 118163009561 putative translocon binding site; other site 118163009562 protein-rRNA interface [nucleotide binding]; other site 118163009563 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 118163009564 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 118163009565 G-X-X-G motif; other site 118163009566 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 118163009567 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 118163009568 23S rRNA interface [nucleotide binding]; other site 118163009569 5S rRNA interface [nucleotide binding]; other site 118163009570 putative antibiotic binding site [chemical binding]; other site 118163009571 L25 interface [polypeptide binding]; other site 118163009572 L27 interface [polypeptide binding]; other site 118163009573 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 118163009574 23S rRNA interface [nucleotide binding]; other site 118163009575 putative translocon interaction site; other site 118163009576 signal recognition particle (SRP54) interaction site; other site 118163009577 L23 interface [polypeptide binding]; other site 118163009578 trigger factor interaction site; other site 118163009579 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 118163009580 ribosomal protein L14; Region: rpl14; CHL00057 118163009581 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 118163009582 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 118163009583 RNA binding site [nucleotide binding]; other site 118163009584 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 118163009585 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 118163009586 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 118163009587 ribosomal protein S8; Region: rps8; CHL00042 118163009588 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 118163009589 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 118163009590 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 118163009591 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 118163009592 23S rRNA interface [nucleotide binding]; other site 118163009593 5S rRNA interface [nucleotide binding]; other site 118163009594 L27 interface [polypeptide binding]; other site 118163009595 L5 interface [polypeptide binding]; other site 118163009596 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 118163009597 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 118163009598 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 118163009599 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 118163009600 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 118163009601 SecY translocase; Region: SecY; pfam00344 118163009602 adenylate kinase; Provisional; Region: adk; PRK02496 118163009603 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 118163009604 AMP-binding site [chemical binding]; other site 118163009605 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 118163009606 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 118163009607 rRNA binding site [nucleotide binding]; other site 118163009608 predicted 30S ribosome binding site; other site 118163009609 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 118163009610 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 118163009611 30S ribosomal protein S13; Region: bact_S13; TIGR03631 118163009612 30S ribosomal protein S11; Validated; Region: PRK05309 118163009613 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 118163009614 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 118163009615 alphaNTD homodimer interface [polypeptide binding]; other site 118163009616 alphaNTD - beta interaction site [polypeptide binding]; other site 118163009617 alphaNTD - beta' interaction site [polypeptide binding]; other site 118163009618 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 118163009619 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 118163009620 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 118163009621 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 118163009622 dimerization interface 3.5A [polypeptide binding]; other site 118163009623 active site 118163009624 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 118163009625 23S rRNA interface [nucleotide binding]; other site 118163009626 L3 interface [polypeptide binding]; other site 118163009627 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 118163009628 ribosomal protein L31; Validated; Region: rpl31; CHL00136 118163009629 peptide chain release factor 1; Validated; Region: prfA; PRK00591 118163009630 This domain is found in peptide chain release factors; Region: PCRF; smart00937 118163009631 RF-1 domain; Region: RF-1; pfam00472 118163009632 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 118163009633 active site 118163009634 catalytic triad [active] 118163009635 oxyanion hole [active] 118163009636 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 118163009637 ArsC family; Region: ArsC; pfam03960 118163009638 putative catalytic residues [active] 118163009639 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163009640 dimer interface [polypeptide binding]; other site 118163009641 [2Fe-2S] cluster binding site [ion binding]; other site 118163009642 FOG: CBS domain [General function prediction only]; Region: COG0517 118163009643 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 118163009644 CP12 domain; Region: CP12; cl14670 118163009645 NifT/FixU protein; Region: NifT; pfam06988 118163009646 NifZ domain; Region: NifZ; pfam04319 118163009647 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 118163009648 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 118163009649 active site 118163009650 catalytic residues [active] 118163009651 metal binding site [ion binding]; metal-binding site 118163009652 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 118163009653 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 118163009654 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 118163009655 dimerization interface [polypeptide binding]; other site 118163009656 DPS ferroxidase diiron center [ion binding]; other site 118163009657 ion pore; other site 118163009658 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 118163009659 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 118163009660 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 118163009661 trimer interface [polypeptide binding]; other site 118163009662 active site 118163009663 substrate binding site [chemical binding]; other site 118163009664 CoA binding site [chemical binding]; other site 118163009665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 118163009666 FOG: CBS domain [General function prediction only]; Region: COG0517 118163009667 FOG: CBS domain [General function prediction only]; Region: COG0517 118163009668 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 118163009669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163009670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163009671 metal binding site [ion binding]; metal-binding site 118163009672 active site 118163009673 I-site; other site 118163009674 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 118163009675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163009676 FeS/SAM binding site; other site 118163009677 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 118163009678 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 118163009679 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 118163009680 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 118163009681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163009682 catalytic residue [active] 118163009683 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 118163009684 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 118163009685 trimerization site [polypeptide binding]; other site 118163009686 active site 118163009687 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 118163009688 NifU-like domain; Region: NifU; pfam01106 118163009689 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 118163009690 nitrogenase iron protein; Region: nifH; TIGR01287 118163009691 Nucleotide-binding sites [chemical binding]; other site 118163009692 Walker A motif; other site 118163009693 Switch I region of nucleotide binding site; other site 118163009694 Fe4S4 binding sites [ion binding]; other site 118163009695 Switch II region of nucleotide binding site; other site 118163009696 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 118163009697 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 118163009698 MoFe protein alpha/beta subunit interactions; other site 118163009699 Alpha subunit P cluster binding residues; other site 118163009700 FeMoco binding residues [chemical binding]; other site 118163009701 MoFe protein alpha subunit/Fe protein contacts; other site 118163009702 MoFe protein dimer/ dimer interactions; other site 118163009703 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 118163009704 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 118163009705 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 118163009706 MoFe protein beta/alpha subunit interactions; other site 118163009707 Beta subunit P cluster binding residues; other site 118163009708 MoFe protein beta subunit/Fe protein contacts; other site 118163009709 MoFe protein dimer/ dimer interactions; other site 118163009710 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163009711 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 118163009712 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 118163009713 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 118163009714 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 118163009715 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 118163009716 Protein of unknown function, DUF269; Region: DUF269; pfam03270 118163009717 Rop-like; Region: Rop-like; pfam05082 118163009718 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 118163009719 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 118163009720 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 118163009721 ATP binding site [chemical binding]; other site 118163009722 substrate interface [chemical binding]; other site 118163009723 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 118163009724 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163009725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163009726 catalytic loop [active] 118163009727 iron binding site [ion binding]; other site 118163009728 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 118163009729 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 118163009730 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 118163009731 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 118163009732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 118163009733 dimer interface [polypeptide binding]; other site 118163009734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009735 catalytic residue [active] 118163009736 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 118163009737 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 118163009738 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 118163009739 trimer interface [polypeptide binding]; other site 118163009740 active site 118163009741 UDP-GlcNAc binding site [chemical binding]; other site 118163009742 lipid binding site [chemical binding]; lipid-binding site 118163009743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163009744 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 118163009745 NAD(P) binding site [chemical binding]; other site 118163009746 active site 118163009747 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 118163009748 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 118163009749 putative ADP-binding pocket [chemical binding]; other site 118163009750 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 118163009751 ABC-2 type transporter; Region: ABC2_membrane; cl17235 118163009752 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 118163009753 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 118163009754 Walker A/P-loop; other site 118163009755 ATP binding site [chemical binding]; other site 118163009756 Q-loop/lid; other site 118163009757 ABC transporter signature motif; other site 118163009758 Walker B; other site 118163009759 D-loop; other site 118163009760 H-loop/switch region; other site 118163009761 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 118163009762 putative carbohydrate binding site [chemical binding]; other site 118163009763 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163009764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163009765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163009766 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 118163009767 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 118163009768 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 118163009769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 118163009770 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 118163009771 WYL domain; Region: WYL; pfam13280 118163009772 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 118163009773 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 118163009774 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 118163009775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 118163009776 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 118163009777 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 118163009778 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 118163009779 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 118163009780 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 118163009781 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 118163009782 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 118163009783 RNA polymerase sigma factor; Validated; Region: PRK05949 118163009784 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 118163009785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163009786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163009787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163009788 DNA binding residues [nucleotide binding] 118163009789 TPR repeat; Region: TPR_11; pfam13414 118163009790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009791 binding surface 118163009792 TPR motif; other site 118163009793 TPR repeat; Region: TPR_11; pfam13414 118163009794 TPR repeat; Region: TPR_11; pfam13414 118163009795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009796 binding surface 118163009797 TPR motif; other site 118163009798 PsbP; Region: PsbP; pfam01789 118163009799 Maf-like protein; Region: Maf; pfam02545 118163009800 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 118163009801 active site 118163009802 dimer interface [polypeptide binding]; other site 118163009803 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 118163009804 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 118163009805 NAD binding site [chemical binding]; other site 118163009806 catalytic residues [active] 118163009807 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 118163009808 Protein of unknown function DUF58; Region: DUF58; pfam01882 118163009809 hybrid cluster protein; Provisional; Region: PRK05290 118163009810 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 118163009811 ACS interaction site; other site 118163009812 CODH interaction site; other site 118163009813 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 118163009814 hybrid metal cluster; other site 118163009815 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 118163009816 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 118163009817 putative acyl-acceptor binding pocket; other site 118163009818 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 118163009819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163009820 S-adenosylmethionine binding site [chemical binding]; other site 118163009821 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 118163009822 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 118163009823 dimer interface [polypeptide binding]; other site 118163009824 substrate binding site [chemical binding]; other site 118163009825 metal binding sites [ion binding]; metal-binding site 118163009826 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 118163009827 Flavoprotein; Region: Flavoprotein; pfam02441 118163009828 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 118163009829 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 118163009830 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163009831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163009832 catalytic loop [active] 118163009833 iron binding site [ion binding]; other site 118163009834 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 118163009835 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163009836 Ligand Binding Site [chemical binding]; other site 118163009837 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163009838 Ligand Binding Site [chemical binding]; other site 118163009839 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 118163009840 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 118163009841 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163009842 Chain length determinant protein; Region: Wzz; cl15801 118163009843 AAA domain; Region: AAA_31; pfam13614 118163009844 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 118163009845 active site 118163009846 SAM binding site [chemical binding]; other site 118163009847 homodimer interface [polypeptide binding]; other site 118163009848 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 118163009849 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 118163009850 active site 118163009851 PIN domain; Region: PIN_3; pfam13470 118163009852 DNA binding domain, excisionase family; Region: excise; TIGR01764 118163009853 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 118163009854 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 118163009855 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 118163009856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163009857 putative substrate translocation pore; other site 118163009858 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009859 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163009860 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009861 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163009862 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163009864 primosome assembly protein PriA; Validated; Region: PRK05580 118163009865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163009866 ATP binding site [chemical binding]; other site 118163009867 putative Mg++ binding site [ion binding]; other site 118163009868 helicase superfamily c-terminal domain; Region: HELICc; smart00490 118163009869 ATP-binding site [chemical binding]; other site 118163009870 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 118163009871 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 118163009872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163009873 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163009874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163009875 DNA binding residues [nucleotide binding] 118163009876 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 118163009877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163009878 DNA binding residues [nucleotide binding] 118163009879 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 118163009880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163009881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163009882 active site 118163009883 phosphorylation site [posttranslational modification] 118163009884 intermolecular recognition site; other site 118163009885 dimerization interface [polypeptide binding]; other site 118163009886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163009887 DNA binding site [nucleotide binding] 118163009888 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 118163009889 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 118163009890 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 118163009891 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 118163009892 heme binding pocket [chemical binding]; other site 118163009893 heme ligand [chemical binding]; other site 118163009894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 118163009895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 118163009896 dimerization interface [polypeptide binding]; other site 118163009897 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 118163009898 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 118163009899 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 118163009900 Dynamin family; Region: Dynamin_N; pfam00350 118163009901 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 118163009902 G1 box; other site 118163009903 GTP/Mg2+ binding site [chemical binding]; other site 118163009904 Switch I region; other site 118163009905 G2 box; other site 118163009906 Switch II region; other site 118163009907 G3 box; other site 118163009908 G4 box; other site 118163009909 G5 box; other site 118163009910 Domain of unknown function (DUF697); Region: DUF697; pfam05128 118163009911 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 118163009912 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 118163009913 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 118163009914 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 118163009915 Uncharacterized conserved protein [Function unknown]; Region: COG3349 118163009916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163009917 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 118163009918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 118163009919 active site 118163009920 ATP binding site [chemical binding]; other site 118163009921 Cupin domain; Region: Cupin_2; pfam07883 118163009922 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 118163009923 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 118163009924 Ligand binding site; other site 118163009925 Putative Catalytic site; other site 118163009926 DXD motif; other site 118163009927 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 118163009928 DHH family; Region: DHH; pfam01368 118163009929 DHHA1 domain; Region: DHHA1; pfam02272 118163009930 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163009931 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 118163009932 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 118163009933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163009934 binding surface 118163009935 TPR motif; other site 118163009936 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 118163009937 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 118163009938 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 118163009939 homodimer interface [polypeptide binding]; other site 118163009940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009941 catalytic residue [active] 118163009942 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 118163009943 active site 118163009944 ribulose/triose binding site [chemical binding]; other site 118163009945 phosphate binding site [ion binding]; other site 118163009946 substrate (anthranilate) binding pocket [chemical binding]; other site 118163009947 product (indole) binding pocket [chemical binding]; other site 118163009948 Uncharacterized conserved protein [Function unknown]; Region: COG2836 118163009949 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 118163009950 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 118163009951 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163009952 putative metal binding site; other site 118163009953 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 118163009954 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 118163009955 Protein phosphatase 2C; Region: PP2C; pfam00481 118163009956 active site 118163009957 CHAT domain; Region: CHAT; cl17868 118163009958 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163009959 phosphopeptide binding site; other site 118163009960 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 118163009961 putative active site [active] 118163009962 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 118163009963 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 118163009964 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 118163009965 Acylphosphatase; Region: Acylphosphatase; pfam00708 118163009966 HypF finger; Region: zf-HYPF; pfam07503 118163009967 HypF finger; Region: zf-HYPF; pfam07503 118163009968 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 118163009969 HupF/HypC family; Region: HupF_HypC; pfam01455 118163009970 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 118163009971 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 118163009972 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 118163009973 active site 1 [active] 118163009974 dimer interface [polypeptide binding]; other site 118163009975 hexamer interface [polypeptide binding]; other site 118163009976 active site 2 [active] 118163009977 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 118163009978 homodimer interface [polypeptide binding]; other site 118163009979 substrate-cofactor binding pocket; other site 118163009980 Aminotransferase class IV; Region: Aminotran_4; pfam01063 118163009981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163009982 catalytic residue [active] 118163009983 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 118163009984 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 118163009985 dimer interface [polypeptide binding]; other site 118163009986 tetramer interface [polypeptide binding]; other site 118163009987 PYR/PP interface [polypeptide binding]; other site 118163009988 TPP binding site [chemical binding]; other site 118163009989 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 118163009990 TPP-binding site; other site 118163009991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 118163009992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163009993 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 118163009994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163009995 S-adenosylmethionine binding site [chemical binding]; other site 118163009996 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163009997 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163009998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163009999 Walker A/P-loop; other site 118163010000 ATP binding site [chemical binding]; other site 118163010001 Q-loop/lid; other site 118163010002 ABC transporter signature motif; other site 118163010003 Walker B; other site 118163010004 D-loop; other site 118163010005 H-loop/switch region; other site 118163010006 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 118163010007 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163010008 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 118163010009 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 118163010010 Uncharacterized conserved protein [Function unknown]; Region: COG1434 118163010011 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 118163010012 putative active site [active] 118163010013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163010014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163010015 active site 118163010016 catalytic tetrad [active] 118163010017 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 118163010018 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 118163010019 dimer interface [polypeptide binding]; other site 118163010020 RNA polymerase sigma factor; Provisional; Region: PRK12518 118163010021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163010022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163010023 DNA binding residues [nucleotide binding] 118163010024 PhoD-like phosphatase; Region: PhoD; pfam09423 118163010025 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 118163010026 putative active site [active] 118163010027 Phosphoglycerate kinase; Region: PGK; pfam00162 118163010028 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 118163010029 substrate binding site [chemical binding]; other site 118163010030 hinge regions; other site 118163010031 ADP binding site [chemical binding]; other site 118163010032 catalytic site [active] 118163010033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163010034 Ligand Binding Site [chemical binding]; other site 118163010035 GMP synthase; Reviewed; Region: guaA; PRK00074 118163010036 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 118163010037 AMP/PPi binding site [chemical binding]; other site 118163010038 candidate oxyanion hole; other site 118163010039 catalytic triad [active] 118163010040 potential glutamine specificity residues [chemical binding]; other site 118163010041 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 118163010042 ATP Binding subdomain [chemical binding]; other site 118163010043 Ligand Binding sites [chemical binding]; other site 118163010044 Dimerization subdomain; other site 118163010045 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 118163010046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163010047 Walker A/P-loop; other site 118163010048 ATP binding site [chemical binding]; other site 118163010049 Q-loop/lid; other site 118163010050 ABC transporter signature motif; other site 118163010051 Walker B; other site 118163010052 D-loop; other site 118163010053 H-loop/switch region; other site 118163010054 Protein of unknown function (DUF732); Region: DUF732; pfam05305 118163010055 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163010056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 118163010057 flavodoxin FldA; Validated; Region: PRK09267 118163010058 F plasmid transfer operon protein; Region: TraF; pfam13728 118163010059 Photosystem II protein; Region: PSII; cl08223 118163010060 Photosystem II protein; Region: PSII; cl08223 118163010061 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 118163010062 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 118163010063 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 118163010064 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 118163010065 FeoA domain; Region: FeoA; pfam04023 118163010066 FeoA domain; Region: FeoA; pfam04023 118163010067 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 118163010068 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 118163010069 G1 box; other site 118163010070 GTP/Mg2+ binding site [chemical binding]; other site 118163010071 Switch I region; other site 118163010072 G2 box; other site 118163010073 G3 box; other site 118163010074 Switch II region; other site 118163010075 G4 box; other site 118163010076 G5 box; other site 118163010077 Nucleoside recognition; Region: Gate; pfam07670 118163010078 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 118163010079 FeoC like transcriptional regulator; Region: FeoC; pfam09012 118163010080 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 118163010081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163010082 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163010083 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163010084 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163010085 structural tetrad; other site 118163010086 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 118163010087 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 118163010088 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163010089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163010090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163010091 Transcriptional regulator [Transcription]; Region: LytR; COG1316 118163010092 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 118163010093 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 118163010094 Uncharacterized conserved protein [Function unknown]; Region: COG0432 118163010095 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 118163010096 catalytic core [active] 118163010097 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 118163010098 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 118163010099 putative dimer interface [polypeptide binding]; other site 118163010100 ChaB; Region: ChaB; cl01887 118163010101 chaperone protein DnaJ; Provisional; Region: PRK14299 118163010102 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163010103 HSP70 interaction site [polypeptide binding]; other site 118163010104 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 118163010105 substrate binding site [polypeptide binding]; other site 118163010106 dimer interface [polypeptide binding]; other site 118163010107 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 118163010108 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 118163010109 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 118163010110 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 118163010111 Predicted membrane protein [Function unknown]; Region: COG3431 118163010112 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 118163010113 PRC-barrel domain; Region: PRC; pfam05239 118163010114 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 118163010115 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 118163010116 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 118163010117 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 118163010118 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 118163010119 Walker A/P-loop; other site 118163010120 ATP binding site [chemical binding]; other site 118163010121 Q-loop/lid; other site 118163010122 ABC transporter signature motif; other site 118163010123 Walker B; other site 118163010124 D-loop; other site 118163010125 H-loop/switch region; other site 118163010126 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 118163010127 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 118163010128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163010129 dimer interface [polypeptide binding]; other site 118163010130 conserved gate region; other site 118163010131 putative PBP binding loops; other site 118163010132 ABC-ATPase subunit interface; other site 118163010133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163010134 dimer interface [polypeptide binding]; other site 118163010135 conserved gate region; other site 118163010136 putative PBP binding loops; other site 118163010137 ABC-ATPase subunit interface; other site 118163010138 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 118163010139 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 118163010140 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 118163010141 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 118163010142 active site residue [active] 118163010143 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163010144 HEAT repeats; Region: HEAT_2; pfam13646 118163010145 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 118163010146 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 118163010147 Walker A motif; other site 118163010148 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 118163010149 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 118163010150 tetramer interface [polypeptide binding]; other site 118163010151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163010152 catalytic residue [active] 118163010153 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 118163010154 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 118163010155 Ligand Binding Site [chemical binding]; other site 118163010156 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163010157 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163010158 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163010159 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163010160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163010161 dimer interface [polypeptide binding]; other site 118163010162 phosphorylation site [posttranslational modification] 118163010163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163010164 ATP binding site [chemical binding]; other site 118163010165 Mg2+ binding site [ion binding]; other site 118163010166 G-X-G motif; other site 118163010167 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 118163010168 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 118163010169 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 118163010170 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 118163010171 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 118163010172 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 118163010173 dimerization interface [polypeptide binding]; other site 118163010174 active site 118163010175 Uncharacterized conserved protein [Function unknown]; Region: COG5607 118163010176 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 118163010177 hypothetical protein; Provisional; Region: PRK02237 118163010178 DNA adenine methylase (dam); Region: dam; TIGR00571 118163010179 Transcriptional regulators [Transcription]; Region: MarR; COG1846 118163010180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163010181 putative DNA binding site [nucleotide binding]; other site 118163010182 putative Zn2+ binding site [ion binding]; other site 118163010183 MarR family; Region: MarR_2; cl17246 118163010184 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 118163010185 heme-binding site [chemical binding]; other site 118163010186 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 118163010187 Clp protease ATP binding subunit; Region: clpC; CHL00095 118163010188 Clp amino terminal domain; Region: Clp_N; pfam02861 118163010189 Clp amino terminal domain; Region: Clp_N; pfam02861 118163010190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163010191 Walker A motif; other site 118163010192 ATP binding site [chemical binding]; other site 118163010193 Walker B motif; other site 118163010194 arginine finger; other site 118163010195 UvrB/uvrC motif; Region: UVR; pfam02151 118163010196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163010197 Walker A motif; other site 118163010198 ATP binding site [chemical binding]; other site 118163010199 Walker B motif; other site 118163010200 arginine finger; other site 118163010201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 118163010202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 118163010203 diaminopimelate decarboxylase; Region: lysA; TIGR01048 118163010204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 118163010205 active site 118163010206 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 118163010207 substrate binding site [chemical binding]; other site 118163010208 catalytic residues [active] 118163010209 dimer interface [polypeptide binding]; other site 118163010210 TIGR00159 family protein; Region: TIGR00159 118163010211 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 118163010212 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 118163010213 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 118163010214 catalytic residue [active] 118163010215 putative FPP diphosphate binding site; other site 118163010216 putative FPP binding hydrophobic cleft; other site 118163010217 dimer interface [polypeptide binding]; other site 118163010218 putative IPP diphosphate binding site; other site 118163010219 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 118163010220 active site 118163010221 catalytic triad [active] 118163010222 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163010223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163010224 phosphopeptide binding site; other site 118163010225 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163010226 metal binding site [ion binding]; metal-binding site 118163010227 active site 118163010228 I-site; other site 118163010229 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163010230 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163010231 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163010232 phosphopeptide binding site; other site 118163010233 PAS domain S-box; Region: sensory_box; TIGR00229 118163010234 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163010235 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163010236 metal binding site [ion binding]; metal-binding site 118163010237 active site 118163010238 I-site; other site 118163010239 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163010240 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163010241 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163010242 phosphopeptide binding site; other site 118163010243 PAS domain S-box; Region: sensory_box; TIGR00229 118163010244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163010245 putative active site [active] 118163010246 heme pocket [chemical binding]; other site 118163010247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163010248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163010249 metal binding site [ion binding]; metal-binding site 118163010250 active site 118163010251 I-site; other site 118163010252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 118163010253 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163010254 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163010255 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 118163010256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163010257 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 118163010258 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 118163010259 Predicted membrane protein [Function unknown]; Region: COG3431 118163010260 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 118163010261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163010262 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 118163010263 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 118163010264 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 118163010265 Family description; Region: UvrD_C_2; pfam13538 118163010266 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 118163010267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 118163010268 non-specific DNA binding site [nucleotide binding]; other site 118163010269 salt bridge; other site 118163010270 sequence-specific DNA binding site [nucleotide binding]; other site 118163010271 Domain of unknown function (DUF955); Region: DUF955; pfam06114 118163010272 Bacterial Ig-like domain; Region: Big_5; pfam13205 118163010273 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 118163010274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163010275 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 118163010276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163010277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163010278 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163010279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163010280 motif II; other site 118163010281 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163010282 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 118163010283 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 118163010284 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 118163010285 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163010286 putative active site [active] 118163010287 hypothetical protein; Provisional; Region: PRK06850 118163010288 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 118163010289 Active Sites [active] 118163010290 photosystem II protein K; Region: psbK; CHL00047 118163010291 HEAT repeats; Region: HEAT_2; pfam13646 118163010292 Conserved TM helix; Region: TM_helix; pfam05552 118163010293 Conserved TM helix; Region: TM_helix; pfam05552 118163010294 Conserved TM helix; Region: TM_helix; pfam05552 118163010295 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 118163010296 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163010297 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163010298 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 118163010299 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 118163010300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163010301 FeS/SAM binding site; other site 118163010302 HemN C-terminal domain; Region: HemN_C; pfam06969 118163010303 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 118163010304 heme binding pocket [chemical binding]; other site 118163010305 heme ligand [chemical binding]; other site 118163010306 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 118163010307 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 118163010308 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 118163010309 diiron binding motif [ion binding]; other site 118163010310 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163010311 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163010312 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 118163010313 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163010314 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163010315 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 118163010316 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 118163010317 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 118163010318 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 118163010319 active site 118163010320 (T/H)XGH motif; other site 118163010321 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 118163010322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 118163010323 active site 118163010324 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 118163010325 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 118163010326 RNA binding surface [nucleotide binding]; other site 118163010327 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 118163010328 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 118163010329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 118163010330 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 118163010331 Soluble P-type ATPase [General function prediction only]; Region: COG4087 118163010332 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 118163010333 PRC-barrel domain; Region: PRC; pfam05239 118163010334 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 118163010335 PRC-barrel domain; Region: PRC; pfam05239 118163010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 118163010337 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 118163010338 dihydrodipicolinate reductase; Provisional; Region: PRK00048 118163010339 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 118163010340 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 118163010341 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163010342 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163010343 ligand binding site [chemical binding]; other site 118163010344 flexible hinge region; other site 118163010345 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 118163010346 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 118163010347 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 118163010348 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 118163010349 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 118163010350 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163010351 Methyltransferase domain; Region: Methyltransf_12; pfam08242 118163010352 S-adenosylmethionine binding site [chemical binding]; other site 118163010353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163010354 active site 118163010355 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 118163010356 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 118163010357 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 118163010358 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 118163010359 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 118163010360 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 118163010361 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 118163010362 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 118163010363 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 118163010364 TM-ABC transporter signature motif; other site 118163010365 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 118163010366 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 118163010367 Walker A/P-loop; other site 118163010368 ATP binding site [chemical binding]; other site 118163010369 Q-loop/lid; other site 118163010370 ABC transporter signature motif; other site 118163010371 Walker B; other site 118163010372 D-loop; other site 118163010373 H-loop/switch region; other site 118163010374 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 118163010375 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 118163010376 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 118163010377 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 118163010378 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 118163010379 [4Fe-4S] binding site [ion binding]; other site 118163010380 molybdopterin cofactor binding site; other site 118163010381 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 118163010382 molybdopterin cofactor binding site; other site 118163010383 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 118163010384 aspartate aminotransferase; Provisional; Region: PRK05764 118163010385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163010386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163010387 homodimer interface [polypeptide binding]; other site 118163010388 catalytic residue [active] 118163010389 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 118163010390 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 118163010391 putative acyl-acceptor binding pocket; other site 118163010392 Predicted methyltransferases [General function prediction only]; Region: COG0313 118163010393 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 118163010394 putative SAM binding site [chemical binding]; other site 118163010395 putative homodimer interface [polypeptide binding]; other site 118163010396 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 118163010397 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 118163010398 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 118163010399 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 118163010400 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 118163010401 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 118163010402 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 118163010403 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 118163010404 active site 118163010405 dimer interface [polypeptide binding]; other site 118163010406 motif 1; other site 118163010407 motif 2; other site 118163010408 motif 3; other site 118163010409 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 118163010410 anticodon binding site; other site 118163010411 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 118163010412 homodecamer interface [polypeptide binding]; other site 118163010413 GTP cyclohydrolase I; Provisional; Region: PLN03044 118163010414 active site 118163010415 putative catalytic site residues [active] 118163010416 zinc binding site [ion binding]; other site 118163010417 GTP-CH-I/GFRP interaction surface; other site 118163010418 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 118163010419 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 118163010420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163010421 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 118163010422 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 118163010423 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 118163010424 arginine-tRNA ligase; Region: PLN02286 118163010425 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 118163010426 active site 118163010427 HIGH motif; other site 118163010428 KMSK motif region; other site 118163010429 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 118163010430 tRNA binding surface [nucleotide binding]; other site 118163010431 anticodon binding site; other site 118163010432 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 118163010433 catalytic triad [active] 118163010434 conserved cis-peptide bond; other site 118163010435 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 118163010436 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 118163010437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163010438 FtsX-like permease family; Region: FtsX; pfam02687 118163010439 photosystem I subunit VII; Region: psaC; CHL00065 118163010440 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 118163010441 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 118163010442 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 118163010443 active site 118163010444 dimer interface [polypeptide binding]; other site 118163010445 catalytic residue [active] 118163010446 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 118163010447 Ca2+ binding site [ion binding]; other site 118163010448 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 118163010449 propionate/acetate kinase; Provisional; Region: PRK12379 118163010450 putative pectinesterase; Region: PLN02432; cl01911 118163010451 Right handed beta helix region; Region: Beta_helix; pfam13229 118163010452 Right handed beta helix region; Region: Beta_helix; pfam13229 118163010453 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 118163010454 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 118163010455 Walker A/P-loop; other site 118163010456 ATP binding site [chemical binding]; other site 118163010457 Q-loop/lid; other site 118163010458 ABC transporter signature motif; other site 118163010459 Walker B; other site 118163010460 D-loop; other site 118163010461 H-loop/switch region; other site 118163010462 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 118163010463 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 118163010464 active site 118163010465 substrate binding site [chemical binding]; other site 118163010466 FMN binding site [chemical binding]; other site 118163010467 putative catalytic residues [active] 118163010468 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 118163010469 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 118163010470 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 118163010471 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 118163010472 Predicted membrane protein [Function unknown]; Region: COG2119 118163010473 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 118163010474 Predicted membrane protein [Function unknown]; Region: COG2119 118163010475 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 118163010476 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 118163010477 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 118163010478 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 118163010479 DHH family; Region: DHH; pfam01368 118163010480 DHHA1 domain; Region: DHHA1; pfam02272 118163010481 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 118163010482 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 118163010483 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163010484 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163010485 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 118163010486 protein binding site [polypeptide binding]; other site 118163010487 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 118163010488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163010489 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 118163010490 Peptidase family M50; Region: Peptidase_M50; pfam02163 118163010491 active site 118163010492 putative substrate binding region [chemical binding]; other site 118163010493 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 118163010494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163010495 acyl-CoA synthetase; Validated; Region: PRK05850 118163010496 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163010497 acyl-activating enzyme (AAE) consensus motif; other site 118163010498 active site 118163010499 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163010500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 118163010501 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 118163010502 active site 118163010503 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 118163010504 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 118163010505 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 118163010506 KR domain; Region: KR; pfam08659 118163010507 putative NADP binding site [chemical binding]; other site 118163010508 active site 118163010509 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163010510 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 118163010511 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163010512 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163010513 proline/glycine betaine transporter; Provisional; Region: PRK10642 118163010514 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 118163010515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 118163010516 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 118163010517 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 118163010518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 118163010519 ATP-grasp domain; Region: ATP-grasp_4; cl17255 118163010520 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 118163010521 IMP binding site; other site 118163010522 dimer interface [polypeptide binding]; other site 118163010523 interdomain contacts; other site 118163010524 partial ornithine binding site; other site 118163010525 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 118163010526 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 118163010527 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 118163010528 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 118163010529 substrate binding site [chemical binding]; other site 118163010530 ATP binding site [chemical binding]; other site 118163010531 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163010532 putative active site [active] 118163010533 integral membrane protein MviN; Region: mviN; TIGR01695 118163010534 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 118163010535 Response regulator receiver domain; Region: Response_reg; pfam00072 118163010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010537 active site 118163010538 phosphorylation site [posttranslational modification] 118163010539 intermolecular recognition site; other site 118163010540 dimerization interface [polypeptide binding]; other site 118163010541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163010542 PAS domain; Region: PAS_9; pfam13426 118163010543 putative active site [active] 118163010544 heme pocket [chemical binding]; other site 118163010545 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163010546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163010547 metal binding site [ion binding]; metal-binding site 118163010548 active site 118163010549 I-site; other site 118163010550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163010551 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 118163010552 Uncharacterized conserved protein [Function unknown]; Region: COG1543 118163010553 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 118163010554 active site 118163010555 substrate binding site [chemical binding]; other site 118163010556 catalytic site [active] 118163010557 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 118163010558 adaptive-response sensory kinase; Validated; Region: PRK09303 118163010559 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 118163010560 tetramer interface [polypeptide binding]; other site 118163010561 dimer interface [polypeptide binding]; other site 118163010562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163010563 dimer interface [polypeptide binding]; other site 118163010564 phosphorylation site [posttranslational modification] 118163010565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163010566 ATP binding site [chemical binding]; other site 118163010567 Mg2+ binding site [ion binding]; other site 118163010568 G-X-G motif; other site 118163010569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163010570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163010571 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 118163010572 Walker A/P-loop; other site 118163010573 ATP binding site [chemical binding]; other site 118163010574 Q-loop/lid; other site 118163010575 ABC transporter signature motif; other site 118163010576 Walker B; other site 118163010577 D-loop; other site 118163010578 H-loop/switch region; other site 118163010579 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163010580 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 118163010581 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 118163010582 DNA protecting protein DprA; Region: dprA; TIGR00732 118163010583 PAS fold; Region: PAS; pfam00989 118163010584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163010585 putative active site [active] 118163010586 heme pocket [chemical binding]; other site 118163010587 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 118163010588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163010589 putative active site [active] 118163010590 heme pocket [chemical binding]; other site 118163010591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163010592 dimer interface [polypeptide binding]; other site 118163010593 phosphorylation site [posttranslational modification] 118163010594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163010595 ATP binding site [chemical binding]; other site 118163010596 Mg2+ binding site [ion binding]; other site 118163010597 G-X-G motif; other site 118163010598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163010599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010600 active site 118163010601 phosphorylation site [posttranslational modification] 118163010602 intermolecular recognition site; other site 118163010603 dimerization interface [polypeptide binding]; other site 118163010604 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 118163010605 Na binding site [ion binding]; other site 118163010606 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163010607 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 118163010608 putative active site [active] 118163010609 putative catalytic triad [active] 118163010610 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 118163010611 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 118163010612 active site 118163010613 catalytic motif [active] 118163010614 Zn binding site [ion binding]; other site 118163010615 TM2 domain; Region: TM2; cl00984 118163010616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163010617 dimerization interface [polypeptide binding]; other site 118163010618 putative DNA binding site [nucleotide binding]; other site 118163010619 putative Zn2+ binding site [ion binding]; other site 118163010620 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 118163010621 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 118163010622 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 118163010623 active site 118163010624 substrate binding site [chemical binding]; other site 118163010625 cosubstrate binding site; other site 118163010626 catalytic site [active] 118163010627 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 118163010628 Transglycosylase; Region: Transgly; pfam00912 118163010629 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 118163010630 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 118163010631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163010632 dimerization interface [polypeptide binding]; other site 118163010633 putative DNA binding site [nucleotide binding]; other site 118163010634 putative Zn2+ binding site [ion binding]; other site 118163010635 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 118163010636 arsenical-resistance protein; Region: acr3; TIGR00832 118163010637 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 118163010638 Low molecular weight phosphatase family; Region: LMWPc; cd00115 118163010639 active site 118163010640 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 118163010641 active site 118163010642 catalytic residues [active] 118163010643 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 118163010644 putative active site [active] 118163010645 putative metal binding site [ion binding]; other site 118163010646 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 118163010647 threonine synthase; Reviewed; Region: PRK06721 118163010648 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 118163010649 homodimer interface [polypeptide binding]; other site 118163010650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163010651 catalytic residue [active] 118163010652 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 118163010653 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 118163010654 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 118163010655 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 118163010656 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 118163010657 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 118163010658 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163010659 HSP70 interaction site [polypeptide binding]; other site 118163010660 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 118163010661 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163010662 S-layer homology domain; Region: SLH; pfam00395 118163010663 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 118163010664 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 118163010665 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163010666 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163010667 active site 118163010668 ATP binding site [chemical binding]; other site 118163010669 substrate binding site [chemical binding]; other site 118163010670 activation loop (A-loop); other site 118163010671 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 118163010672 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163010673 active site 118163010674 ATP binding site [chemical binding]; other site 118163010675 substrate binding site [chemical binding]; other site 118163010676 activation loop (A-loop); other site 118163010677 TPR repeat; Region: TPR_11; pfam13414 118163010678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163010679 binding surface 118163010680 TPR motif; other site 118163010681 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 118163010682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163010683 binding surface 118163010684 TPR motif; other site 118163010685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163010686 binding surface 118163010687 TPR repeat; Region: TPR_11; pfam13414 118163010688 TPR motif; other site 118163010689 TPR repeat; Region: TPR_11; pfam13414 118163010690 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 118163010691 Fasciclin domain; Region: Fasciclin; pfam02469 118163010692 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 118163010693 tetramer interface [polypeptide binding]; other site 118163010694 dimer interface [polypeptide binding]; other site 118163010695 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 118163010696 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 118163010697 Walker A motif; other site 118163010698 ATP binding site [chemical binding]; other site 118163010699 Walker B motif; other site 118163010700 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 118163010701 Domain of unknown function DUF21; Region: DUF21; pfam01595 118163010702 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 118163010703 Transporter associated domain; Region: CorC_HlyC; smart01091 118163010704 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 118163010705 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 118163010706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163010707 ATP binding site [chemical binding]; other site 118163010708 putative Mg++ binding site [ion binding]; other site 118163010709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163010710 nucleotide binding region [chemical binding]; other site 118163010711 ATP-binding site [chemical binding]; other site 118163010712 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 118163010713 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 118163010714 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 118163010715 active site 118163010716 intersubunit interface [polypeptide binding]; other site 118163010717 catalytic residue [active] 118163010718 Response regulator receiver domain; Region: Response_reg; pfam00072 118163010719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010720 active site 118163010721 phosphorylation site [posttranslational modification] 118163010722 intermolecular recognition site; other site 118163010723 dimerization interface [polypeptide binding]; other site 118163010724 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 118163010725 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 118163010726 HlyD family secretion protein; Region: HlyD_3; pfam13437 118163010727 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163010728 ligand binding site [chemical binding]; other site 118163010729 flexible hinge region; other site 118163010730 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 118163010731 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 118163010732 putative active site [active] 118163010733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163010734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163010735 Walker A/P-loop; other site 118163010736 ATP binding site [chemical binding]; other site 118163010737 Q-loop/lid; other site 118163010738 ABC transporter signature motif; other site 118163010739 Walker B; other site 118163010740 D-loop; other site 118163010741 H-loop/switch region; other site 118163010742 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163010743 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 118163010744 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 118163010745 OsmC-like protein; Region: OsmC; cl00767 118163010746 DAK2 domain; Region: Dak2; cl03685 118163010747 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 118163010748 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 118163010749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 118163010750 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 118163010751 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 118163010752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 118163010753 nudix motif; other site 118163010754 nudix motif; other site 118163010755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163010756 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 118163010757 putative ADP-binding pocket [chemical binding]; other site 118163010758 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 118163010759 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 118163010760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163010761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163010762 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 118163010763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163010764 dimer interface [polypeptide binding]; other site 118163010765 conserved gate region; other site 118163010766 putative PBP binding loops; other site 118163010767 ABC-ATPase subunit interface; other site 118163010768 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 118163010769 HAS barrel domain; Region: HAS-barrel; pfam09378 118163010770 SPRY domain; Region: SPRY; cl02614 118163010771 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 118163010772 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 118163010773 HIGH motif; other site 118163010774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 118163010775 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 118163010776 active site 118163010777 KMSKS motif; other site 118163010778 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 118163010779 tRNA binding surface [nucleotide binding]; other site 118163010780 anticodon binding site; other site 118163010781 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 118163010782 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 118163010783 MgtE intracellular N domain; Region: MgtE_N; smart00924 118163010784 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 118163010785 Divalent cation transporter; Region: MgtE; pfam01769 118163010786 MAPEG family; Region: MAPEG; pfam01124 118163010787 Cytochrome c; Region: Cytochrom_C; cl11414 118163010788 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 118163010789 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 118163010790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163010791 S-adenosylmethionine binding site [chemical binding]; other site 118163010792 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 118163010793 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 118163010794 Walker A/P-loop; other site 118163010795 ATP binding site [chemical binding]; other site 118163010796 Q-loop/lid; other site 118163010797 ABC transporter signature motif; other site 118163010798 Walker B; other site 118163010799 D-loop; other site 118163010800 H-loop/switch region; other site 118163010801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163010802 TPR motif; other site 118163010803 binding surface 118163010804 TPR repeat; Region: TPR_11; pfam13414 118163010805 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 118163010806 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 118163010807 putative catalytic cysteine [active] 118163010808 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 118163010809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163010810 FeS/SAM binding site; other site 118163010811 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 118163010812 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 118163010813 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 118163010814 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163010815 dimer interface [polypeptide binding]; other site 118163010816 [2Fe-2S] cluster binding site [ion binding]; other site 118163010817 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 118163010818 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 118163010819 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 118163010820 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 118163010821 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 118163010822 Nitrogen regulatory protein P-II; Region: P-II; smart00938 118163010823 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 118163010824 Nitrogen regulatory protein P-II; Region: P-II; smart00938 118163010825 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 118163010826 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 118163010827 Nucleotide-binding sites [chemical binding]; other site 118163010828 Walker A motif; other site 118163010829 Switch I region of nucleotide binding site; other site 118163010830 Fe4S4 binding sites [ion binding]; other site 118163010831 Switch II region of nucleotide binding site; other site 118163010832 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 118163010833 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 118163010834 trimerization site [polypeptide binding]; other site 118163010835 active site 118163010836 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 118163010837 NifU-like domain; Region: NifU; pfam01106 118163010838 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 118163010839 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 118163010840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163010841 catalytic residue [active] 118163010842 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 118163010843 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 118163010844 putative heme binding site [chemical binding]; other site 118163010845 Phosphotransferase enzyme family; Region: APH; pfam01636 118163010846 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 118163010847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163010848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010849 active site 118163010850 phosphorylation site [posttranslational modification] 118163010851 intermolecular recognition site; other site 118163010852 dimerization interface [polypeptide binding]; other site 118163010853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163010854 DNA binding residues [nucleotide binding] 118163010855 dimerization interface [polypeptide binding]; other site 118163010856 Response regulator receiver domain; Region: Response_reg; pfam00072 118163010857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010858 active site 118163010859 phosphorylation site [posttranslational modification] 118163010860 intermolecular recognition site; other site 118163010861 dimerization interface [polypeptide binding]; other site 118163010862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 118163010863 Histidine kinase; Region: HisKA_3; pfam07730 118163010864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163010865 ATP binding site [chemical binding]; other site 118163010866 Mg2+ binding site [ion binding]; other site 118163010867 G-X-G motif; other site 118163010868 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 118163010869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163010870 putative active site [active] 118163010871 heme pocket [chemical binding]; other site 118163010872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163010873 dimer interface [polypeptide binding]; other site 118163010874 phosphorylation site [posttranslational modification] 118163010875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163010876 ATP binding site [chemical binding]; other site 118163010877 Mg2+ binding site [ion binding]; other site 118163010878 G-X-G motif; other site 118163010879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010880 active site 118163010881 phosphorylation site [posttranslational modification] 118163010882 intermolecular recognition site; other site 118163010883 dimerization interface [polypeptide binding]; other site 118163010884 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 118163010885 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 118163010886 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 118163010887 NAD binding site [chemical binding]; other site 118163010888 dimerization interface [polypeptide binding]; other site 118163010889 product binding site; other site 118163010890 substrate binding site [chemical binding]; other site 118163010891 zinc binding site [ion binding]; other site 118163010892 catalytic residues [active] 118163010893 ribosomal protein S20; Region: rps20; CHL00102 118163010894 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 118163010895 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 118163010896 active site 118163010897 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 118163010898 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 118163010899 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 118163010900 RPB1 interaction site [polypeptide binding]; other site 118163010901 RPB10 interaction site [polypeptide binding]; other site 118163010902 RPB11 interaction site [polypeptide binding]; other site 118163010903 RPB3 interaction site [polypeptide binding]; other site 118163010904 RPB12 interaction site [polypeptide binding]; other site 118163010905 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 118163010906 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 118163010907 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 118163010908 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 118163010909 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 118163010910 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 118163010911 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 118163010912 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 118163010913 DNA binding site [nucleotide binding] 118163010914 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 118163010915 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 118163010916 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 118163010917 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 118163010918 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 118163010919 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 118163010920 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 118163010921 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 118163010922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 118163010923 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 118163010924 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 118163010925 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 118163010926 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 118163010927 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 118163010928 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 118163010929 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 118163010930 putative acyltransferase; Provisional; Region: PRK05790 118163010931 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 118163010932 dimer interface [polypeptide binding]; other site 118163010933 active site 118163010934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 118163010935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163010936 NAD(P) binding site [chemical binding]; other site 118163010937 active site 118163010938 isocitrate lyase; Provisional; Region: PRK15063 118163010939 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 118163010940 tetramer interface [polypeptide binding]; other site 118163010941 active site 118163010942 Mg2+/Mn2+ binding site [ion binding]; other site 118163010943 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 118163010944 malate synthase A; Region: malate_syn_A; TIGR01344 118163010945 active site 118163010946 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 118163010947 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 118163010948 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 118163010949 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 118163010950 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 118163010951 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 118163010952 active site 118163010953 nucleophile elbow; other site 118163010954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 118163010955 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 118163010956 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 118163010957 active site 118163010958 catalytic triad [active] 118163010959 oxyanion hole [active] 118163010960 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 118163010961 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 118163010962 active site 118163010963 Preprotein translocase SecG subunit; Region: SecG; cl09123 118163010964 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 118163010965 phosphoglyceromutase; Provisional; Region: PRK05434 118163010966 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 118163010967 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 118163010968 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 118163010969 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 118163010970 dihydroorotase; Provisional; Region: PRK07369 118163010971 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 118163010972 active site 118163010973 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 118163010974 arginine decarboxylase; Provisional; Region: PRK05354 118163010975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 118163010976 dimer interface [polypeptide binding]; other site 118163010977 active site 118163010978 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 118163010979 catalytic residues [active] 118163010980 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 118163010981 FO synthase subunit 2; Reviewed; Region: PRK07360 118163010982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163010983 FeS/SAM binding site; other site 118163010984 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 118163010985 dimer interface [polypeptide binding]; other site 118163010986 [2Fe-2S] cluster binding site [ion binding]; other site 118163010987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163010988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163010989 active site 118163010990 phosphorylation site [posttranslational modification] 118163010991 intermolecular recognition site; other site 118163010992 dimerization interface [polypeptide binding]; other site 118163010993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163010994 DNA binding residues [nucleotide binding] 118163010995 dimerization interface [polypeptide binding]; other site 118163010996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163010997 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163010998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163010999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011000 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 118163011001 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 118163011002 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 118163011003 Ligand binding site; other site 118163011004 Putative Catalytic site; other site 118163011005 DXD motif; other site 118163011006 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 118163011007 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 118163011008 Ligand binding site; other site 118163011009 Putative Catalytic site; other site 118163011010 DXD motif; other site 118163011011 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 118163011012 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 118163011013 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 118163011014 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 118163011015 Protein of unknown function, DUF393; Region: DUF393; pfam04134 118163011016 Response regulator receiver domain; Region: Response_reg; pfam00072 118163011017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011018 active site 118163011019 phosphorylation site [posttranslational modification] 118163011020 intermolecular recognition site; other site 118163011021 dimerization interface [polypeptide binding]; other site 118163011022 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 118163011023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 118163011024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 118163011025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163011026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011027 active site 118163011028 phosphorylation site [posttranslational modification] 118163011029 intermolecular recognition site; other site 118163011030 dimerization interface [polypeptide binding]; other site 118163011031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163011032 DNA binding residues [nucleotide binding] 118163011033 dimerization interface [polypeptide binding]; other site 118163011034 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 118163011035 Low molecular weight phosphatase family; Region: LMWPc; cd00115 118163011036 active site 118163011037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 118163011038 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 118163011039 ligand binding site [chemical binding]; other site 118163011040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163011041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163011042 active site 118163011043 catalytic tetrad [active] 118163011044 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 118163011045 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 118163011046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163011047 HSP70 interaction site [polypeptide binding]; other site 118163011048 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 118163011049 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 118163011050 dimer interface [polypeptide binding]; other site 118163011051 active site 118163011052 Schiff base residues; other site 118163011053 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 118163011054 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 118163011055 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 118163011056 putative active site [active] 118163011057 catalytic site [active] 118163011058 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 118163011059 putative ligand binding site [chemical binding]; other site 118163011060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 118163011061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163011062 Coenzyme A binding pocket [chemical binding]; other site 118163011063 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 118163011064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 118163011065 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 118163011066 dimerization interface [polypeptide binding]; other site 118163011067 substrate binding pocket [chemical binding]; other site 118163011068 Trypsin; Region: Trypsin; pfam00089 118163011069 active site 118163011070 substrate binding sites [chemical binding]; other site 118163011071 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163011072 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163011073 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163011074 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163011075 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163011076 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163011077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011078 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 118163011079 putative ADP-binding pocket [chemical binding]; other site 118163011080 integron integrase; Region: integrase_gron; TIGR02249 118163011081 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 118163011082 Int/Topo IB signature motif; other site 118163011083 XamI restriction endonuclease; Region: RE_XamI; pfam09572 118163011084 Methyltransferase domain; Region: Methyltransf_26; pfam13659 118163011085 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 118163011086 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 118163011087 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 118163011088 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 118163011089 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 118163011090 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 118163011091 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 118163011092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163011093 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 118163011094 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 118163011095 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 118163011096 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 118163011097 DNA binding site [nucleotide binding] 118163011098 active site 118163011099 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 118163011100 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 118163011101 FtsX-like permease family; Region: FtsX; pfam02687 118163011102 4-alpha-glucanotransferase; Provisional; Region: PRK14508 118163011103 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 118163011104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 118163011105 substrate binding site [chemical binding]; other site 118163011106 ATP binding site [chemical binding]; other site 118163011107 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 118163011108 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 118163011109 5S rRNA interface [nucleotide binding]; other site 118163011110 CTC domain interface [polypeptide binding]; other site 118163011111 L16 interface [polypeptide binding]; other site 118163011112 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 118163011113 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 118163011114 GDP-binding site [chemical binding]; other site 118163011115 ACT binding site; other site 118163011116 IMP binding site; other site 118163011117 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 118163011118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163011119 Walker A motif; other site 118163011120 ATP binding site [chemical binding]; other site 118163011121 Walker B motif; other site 118163011122 arginine finger; other site 118163011123 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 118163011124 Uncharacterized conserved protein [Function unknown]; Region: COG3937 118163011125 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 118163011126 lipoyl attachment site [posttranslational modification]; other site 118163011127 glycine dehydrogenase; Provisional; Region: PRK05367 118163011128 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 118163011129 tetramer interface [polypeptide binding]; other site 118163011130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163011131 catalytic residue [active] 118163011132 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 118163011133 tetramer interface [polypeptide binding]; other site 118163011134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163011135 catalytic residue [active] 118163011136 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 118163011137 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 118163011138 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 118163011139 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163011140 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 118163011141 recombination protein F; Reviewed; Region: recF; PRK00064 118163011142 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 118163011143 Walker A/P-loop; other site 118163011144 ATP binding site [chemical binding]; other site 118163011145 Q-loop/lid; other site 118163011146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163011147 ABC transporter signature motif; other site 118163011148 Walker B; other site 118163011149 D-loop; other site 118163011150 H-loop/switch region; other site 118163011151 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 118163011152 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 118163011153 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 118163011154 alpha-gamma subunit interface [polypeptide binding]; other site 118163011155 beta-gamma subunit interface [polypeptide binding]; other site 118163011156 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 118163011157 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 118163011158 DDE superfamily endonuclease; Region: DDE_4; pfam13359 118163011159 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 118163011160 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 118163011161 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 118163011162 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 118163011163 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 118163011164 putative valine binding site [chemical binding]; other site 118163011165 dimer interface [polypeptide binding]; other site 118163011166 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 118163011167 cell division protein; Validated; Region: ftsH; CHL00176 118163011168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163011169 Walker A motif; other site 118163011170 ATP binding site [chemical binding]; other site 118163011171 Walker B motif; other site 118163011172 arginine finger; other site 118163011173 Peptidase family M41; Region: Peptidase_M41; pfam01434 118163011174 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163011175 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 118163011176 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 118163011177 dimerization interface [polypeptide binding]; other site 118163011178 FAD binding pocket [chemical binding]; other site 118163011179 FAD binding motif [chemical binding]; other site 118163011180 catalytic residues [active] 118163011181 NAD binding pocket [chemical binding]; other site 118163011182 phosphate binding motif [ion binding]; other site 118163011183 beta-alpha-beta structure motif; other site 118163011184 phosphoribulokinase; Provisional; Region: PRK07429 118163011185 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 118163011186 active site 118163011187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 118163011188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011189 active site 118163011190 phosphorylation site [posttranslational modification] 118163011191 intermolecular recognition site; other site 118163011192 dimerization interface [polypeptide binding]; other site 118163011193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 118163011194 DNA binding site [nucleotide binding] 118163011195 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 118163011196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 118163011197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163011198 dimer interface [polypeptide binding]; other site 118163011199 phosphorylation site [posttranslational modification] 118163011200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163011201 ATP binding site [chemical binding]; other site 118163011202 Mg2+ binding site [ion binding]; other site 118163011203 G-X-G motif; other site 118163011204 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 118163011205 PhoU domain; Region: PhoU; pfam01895 118163011206 PhoU domain; Region: PhoU; pfam01895 118163011207 S-layer homology domain; Region: SLH; pfam00395 118163011208 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 118163011209 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 118163011210 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 118163011211 NAD binding site [chemical binding]; other site 118163011212 dimerization interface [polypeptide binding]; other site 118163011213 product binding site; other site 118163011214 substrate binding site [chemical binding]; other site 118163011215 zinc binding site [ion binding]; other site 118163011216 catalytic residues [active] 118163011217 acyl-CoA synthetase; Validated; Region: PRK05850 118163011218 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 118163011219 acyl-activating enzyme (AAE) consensus motif; other site 118163011220 active site 118163011221 proton extrusion protein PcxA; Provisional; Region: PRK02507 118163011222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 118163011223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163011224 Coenzyme A binding pocket [chemical binding]; other site 118163011225 phosphodiesterase YaeI; Provisional; Region: PRK11340 118163011226 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 118163011227 putative active site [active] 118163011228 putative metal binding site [ion binding]; other site 118163011229 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 118163011230 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 118163011231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 118163011232 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 118163011233 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 118163011234 putative catalytic residues [active] 118163011235 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 118163011236 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 118163011237 putative active site [active] 118163011238 putative dimer interface [polypeptide binding]; other site 118163011239 Peptidase family M48; Region: Peptidase_M48; cl12018 118163011240 photosystem II 47 kDa protein; Region: psbB; CHL00062 118163011241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163011242 Ligand Binding Site [chemical binding]; other site 118163011243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163011244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163011245 active site 118163011246 catalytic tetrad [active] 118163011247 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 118163011248 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 118163011249 hexamer interface [polypeptide binding]; other site 118163011250 ligand binding site [chemical binding]; other site 118163011251 putative active site [active] 118163011252 NAD(P) binding site [chemical binding]; other site 118163011253 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 118163011254 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 118163011255 Walker A/P-loop; other site 118163011256 ATP binding site [chemical binding]; other site 118163011257 Q-loop/lid; other site 118163011258 ABC transporter signature motif; other site 118163011259 Walker B; other site 118163011260 D-loop; other site 118163011261 H-loop/switch region; other site 118163011262 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 118163011263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 118163011264 Walker A/P-loop; other site 118163011265 ATP binding site [chemical binding]; other site 118163011266 Q-loop/lid; other site 118163011267 ABC transporter signature motif; other site 118163011268 Walker B; other site 118163011269 D-loop; other site 118163011270 H-loop/switch region; other site 118163011271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 118163011272 Class I aldolases; Region: Aldolase_Class_I; cl17187 118163011273 catalytic residue [active] 118163011274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163011275 dimer interface [polypeptide binding]; other site 118163011276 phosphorylation site [posttranslational modification] 118163011277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163011278 ATP binding site [chemical binding]; other site 118163011279 Mg2+ binding site [ion binding]; other site 118163011280 G-X-G motif; other site 118163011281 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 118163011282 RibD C-terminal domain; Region: RibD_C; cl17279 118163011283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 118163011284 Protein of unknown function, DUF482; Region: DUF482; pfam04339 118163011285 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 118163011286 CP12 domain; Region: CP12; pfam02672 118163011287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 118163011288 FIST N domain; Region: FIST; pfam08495 118163011289 FIST C domain; Region: FIST_C; pfam10442 118163011290 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 118163011291 ABC1 family; Region: ABC1; cl17513 118163011292 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 118163011293 active site 118163011294 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 118163011295 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163011296 putative catalytic residue [active] 118163011297 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 118163011298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163011299 motif II; other site 118163011300 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 118163011301 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 118163011302 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 118163011303 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 118163011304 generic binding surface II; other site 118163011305 ssDNA binding site; other site 118163011306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163011307 ATP binding site [chemical binding]; other site 118163011308 putative Mg++ binding site [ion binding]; other site 118163011309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163011310 nucleotide binding region [chemical binding]; other site 118163011311 ATP-binding site [chemical binding]; other site 118163011312 elongation factor Ts; Reviewed; Region: tsf; PRK12332 118163011313 UBA/TS-N domain; Region: UBA; pfam00627 118163011314 Elongation factor TS; Region: EF_TS; pfam00889 118163011315 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 118163011316 rRNA interaction site [nucleotide binding]; other site 118163011317 S8 interaction site; other site 118163011318 putative laminin-1 binding site; other site 118163011319 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 118163011320 AMP binding site [chemical binding]; other site 118163011321 fructose-1,6-bisphosphatase family protein; Region: PLN02628 118163011322 metal binding site [ion binding]; metal-binding site 118163011323 active site 118163011324 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 118163011325 putative active site [active] 118163011326 transaldolase; Provisional; Region: PRK03903 118163011327 catalytic residue [active] 118163011328 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 118163011329 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 118163011330 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 118163011331 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 118163011332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 118163011333 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 118163011334 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 118163011335 Cytochrome P450; Region: p450; cl12078 118163011336 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 118163011337 metal ion-dependent adhesion site (MIDAS); other site 118163011338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163011339 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163011340 active site 118163011341 ATP binding site [chemical binding]; other site 118163011342 substrate binding site [chemical binding]; other site 118163011343 activation loop (A-loop); other site 118163011344 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163011345 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163011346 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 118163011347 FOG: WD40 repeat [General function prediction only]; Region: COG2319 118163011348 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 118163011349 structural tetrad; other site 118163011350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 118163011351 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 118163011352 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 118163011353 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 118163011354 MOSC domain; Region: MOSC; pfam03473 118163011355 Cupin domain; Region: Cupin_2; pfam07883 118163011356 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 118163011357 methionine sulfoxide reductase A; Provisional; Region: PRK00058 118163011358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 118163011359 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163011360 putative active site [active] 118163011361 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163011362 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163011363 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163011364 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 118163011365 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 118163011366 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 118163011367 Peptidase family M48; Region: Peptidase_M48; cl12018 118163011368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163011369 TPR motif; other site 118163011370 binding surface 118163011371 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 118163011372 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 118163011373 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 118163011374 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163011375 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011376 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 118163011377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163011378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163011379 homodimer interface [polypeptide binding]; other site 118163011380 catalytic residue [active] 118163011381 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163011382 putative active site [active] 118163011383 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 118163011384 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 118163011385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163011386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163011387 AAA domain; Region: AAA_33; pfam13671 118163011388 AAA domain; Region: AAA_17; pfam13207 118163011389 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 118163011390 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 118163011391 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 118163011392 active site 118163011393 homodimer interface [polypeptide binding]; other site 118163011394 catalytic site [active] 118163011395 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 118163011396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163011397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163011398 ATP binding site [chemical binding]; other site 118163011399 Mg2+ binding site [ion binding]; other site 118163011400 G-X-G motif; other site 118163011401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 118163011402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163011403 dimer interface [polypeptide binding]; other site 118163011404 conserved gate region; other site 118163011405 putative PBP binding loops; other site 118163011406 ABC-ATPase subunit interface; other site 118163011407 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 118163011408 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 118163011409 peptide binding site [polypeptide binding]; other site 118163011410 dimer interface [polypeptide binding]; other site 118163011411 TM2 domain; Region: TM2; pfam05154 118163011412 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 118163011413 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 118163011414 Catalytic site [active] 118163011415 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 118163011416 AIR carboxylase; Region: AIRC; smart01001 118163011417 HEAT repeats; Region: HEAT_2; pfam13646 118163011418 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 118163011419 protein binding surface [polypeptide binding]; other site 118163011420 Response regulator receiver domain; Region: Response_reg; pfam00072 118163011421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011422 active site 118163011423 phosphorylation site [posttranslational modification] 118163011424 intermolecular recognition site; other site 118163011425 dimerization interface [polypeptide binding]; other site 118163011426 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 118163011427 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 118163011428 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 118163011429 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 118163011430 dimerization interface [polypeptide binding]; other site 118163011431 active site 118163011432 metal binding site [ion binding]; metal-binding site 118163011433 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 118163011434 dsRNA binding site [nucleotide binding]; other site 118163011435 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 118163011436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163011437 FeS/SAM binding site; other site 118163011438 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 118163011439 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 118163011440 putative active site [active] 118163011441 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163011442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163011443 active site 118163011444 ATP binding site [chemical binding]; other site 118163011445 substrate binding site [chemical binding]; other site 118163011446 activation loop (A-loop); other site 118163011447 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 118163011448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 118163011449 active site 118163011450 motif I; other site 118163011451 motif II; other site 118163011452 S-layer homology domain; Region: SLH; pfam00395 118163011453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 118163011454 active site 118163011455 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163011456 Predicted transcriptional regulators [Transcription]; Region: COG1733 118163011457 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 118163011458 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 118163011459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163011460 Probable transposase; Region: OrfB_IS605; pfam01385 118163011461 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 118163011462 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 118163011463 active site 118163011464 dimer interface [polypeptide binding]; other site 118163011465 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 118163011466 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 118163011467 active site 118163011468 FMN binding site [chemical binding]; other site 118163011469 substrate binding site [chemical binding]; other site 118163011470 3Fe-4S cluster binding site [ion binding]; other site 118163011471 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 118163011472 domain interface; other site 118163011473 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 118163011474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163011475 binding surface 118163011476 TPR motif; other site 118163011477 TPR repeat; Region: TPR_11; pfam13414 118163011478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163011479 binding surface 118163011480 TPR repeat; Region: TPR_11; pfam13414 118163011481 TPR motif; other site 118163011482 GUN4-like; Region: GUN4; pfam05419 118163011483 ATP cone domain; Region: ATP-cone; pfam03477 118163011484 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 118163011485 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 118163011486 Class I ribonucleotide reductase; Region: RNR_I; cd01679 118163011487 active site 118163011488 dimer interface [polypeptide binding]; other site 118163011489 catalytic residues [active] 118163011490 effector binding site; other site 118163011491 R2 peptide binding site; other site 118163011492 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 118163011493 dimer interface [polypeptide binding]; other site 118163011494 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 118163011495 putative radical transfer pathway; other site 118163011496 diiron center [ion binding]; other site 118163011497 tyrosyl radical; other site 118163011498 Predicted transcriptional regulator [Transcription]; Region: COG1959 118163011499 Transcriptional regulator; Region: Rrf2; cl17282 118163011500 acetolactate synthase; Reviewed; Region: PRK08322 118163011501 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 118163011502 PYR/PP interface [polypeptide binding]; other site 118163011503 dimer interface [polypeptide binding]; other site 118163011504 TPP binding site [chemical binding]; other site 118163011505 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 118163011506 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 118163011507 TPP-binding site [chemical binding]; other site 118163011508 dimer interface [polypeptide binding]; other site 118163011509 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 118163011510 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 118163011511 NAD(P) binding site [chemical binding]; other site 118163011512 catalytic residues [active] 118163011513 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 118163011514 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 118163011515 L-aspartate oxidase; Provisional; Region: PRK06175 118163011516 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 118163011517 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 118163011518 putative active site [active] 118163011519 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 118163011520 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 118163011521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 118163011522 RNA binding surface [nucleotide binding]; other site 118163011523 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163011524 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 118163011525 HSP70 interaction site [polypeptide binding]; other site 118163011526 S-layer homology domain; Region: SLH; pfam00395 118163011527 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 118163011528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011529 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163011530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011532 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163011533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011534 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 118163011535 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 118163011536 GTP binding site; other site 118163011537 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 118163011538 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 118163011539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011540 active site 118163011541 phosphorylation site [posttranslational modification] 118163011542 intermolecular recognition site; other site 118163011543 dimerization interface [polypeptide binding]; other site 118163011544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163011545 Zn2+ binding site [ion binding]; other site 118163011546 Mg2+ binding site [ion binding]; other site 118163011547 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 118163011548 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 118163011549 Substrate binding site; other site 118163011550 Mg++ binding site; other site 118163011551 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 118163011552 active site 118163011553 substrate binding site [chemical binding]; other site 118163011554 CoA binding site [chemical binding]; other site 118163011555 chromosome segregation protein; Provisional; Region: PRK03918 118163011556 Secretin and TonB N terminus short domain; Region: STN; pfam07660 118163011557 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 118163011558 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 118163011559 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 118163011560 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 118163011561 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 118163011562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 118163011563 nucleotide binding site [chemical binding]; other site 118163011564 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 118163011565 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 118163011566 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 118163011567 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 118163011568 TPP-binding site; other site 118163011569 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 118163011570 PYR/PP interface [polypeptide binding]; other site 118163011571 dimer interface [polypeptide binding]; other site 118163011572 TPP binding site [chemical binding]; other site 118163011573 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 118163011574 putative phosphoketolase; Provisional; Region: PRK05261 118163011575 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 118163011576 TPP-binding site; other site 118163011577 XFP C-terminal domain; Region: XFP_C; pfam09363 118163011578 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 118163011579 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 118163011580 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 118163011581 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 118163011582 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 118163011583 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 118163011584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163011585 S-adenosylmethionine binding site [chemical binding]; other site 118163011586 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 118163011587 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 118163011588 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 118163011589 dimer interface [polypeptide binding]; other site 118163011590 catalytic residues [active] 118163011591 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 118163011592 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 118163011593 UreF; Region: UreF; pfam01730 118163011594 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 118163011595 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 118163011596 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 118163011597 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 118163011598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163011599 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 118163011600 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 118163011601 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 118163011602 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163011603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163011604 catalytic residue [active] 118163011605 Cupin domain; Region: Cupin_2; pfam07883 118163011606 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 118163011607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163011608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163011609 ligand binding site [chemical binding]; other site 118163011610 flexible hinge region; other site 118163011611 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 118163011612 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 118163011613 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 118163011614 generic binding surface I; other site 118163011615 generic binding surface II; other site 118163011616 putative hydrolase; Provisional; Region: PRK11460 118163011617 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 118163011618 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 118163011619 Protein export membrane protein; Region: SecD_SecF; cl14618 118163011620 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163011621 putative active site [active] 118163011622 LabA_like proteins; Region: LabA_like/DUF88; cl10034 118163011623 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163011624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163011625 catalytic loop [active] 118163011626 iron binding site [ion binding]; other site 118163011627 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 118163011628 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 118163011629 active site 118163011630 dimerization interface [polypeptide binding]; other site 118163011631 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163011632 HSP70 interaction site [polypeptide binding]; other site 118163011633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163011634 TPR repeat; Region: TPR_11; pfam13414 118163011635 binding surface 118163011636 TPR motif; other site 118163011637 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 118163011638 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 118163011639 dimer interface [polypeptide binding]; other site 118163011640 motif 1; other site 118163011641 active site 118163011642 motif 2; other site 118163011643 motif 3; other site 118163011644 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 118163011645 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 118163011646 hydrophobic ligand binding site; other site 118163011647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 118163011648 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 118163011649 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 118163011650 putative acyl-acceptor binding pocket; other site 118163011651 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 118163011652 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 118163011653 active site 118163011654 HIGH motif; other site 118163011655 KMSKS motif; other site 118163011656 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 118163011657 anticodon binding site; other site 118163011658 tRNA binding surface [nucleotide binding]; other site 118163011659 Uncharacterized conserved protein [Function unknown]; Region: COG1432 118163011660 LabA_like proteins; Region: LabA; cd10911 118163011661 putative metal binding site [ion binding]; other site 118163011662 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 118163011663 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 118163011664 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 118163011665 Stage II sporulation protein; Region: SpoIID; pfam08486 118163011666 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 118163011667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 118163011668 DNA binding site [nucleotide binding] 118163011669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163011670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163011671 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 118163011672 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 118163011673 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 118163011674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 118163011675 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 118163011676 putative FMN binding site [chemical binding]; other site 118163011677 NADPH bind site [chemical binding]; other site 118163011678 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 118163011679 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 118163011680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 118163011681 ligand binding site [chemical binding]; other site 118163011682 flexible hinge region; other site 118163011683 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 118163011684 putative switch regulator; other site 118163011685 non-specific DNA interactions [nucleotide binding]; other site 118163011686 DNA binding site [nucleotide binding] 118163011687 sequence specific DNA binding site [nucleotide binding]; other site 118163011688 putative cAMP binding site [chemical binding]; other site 118163011689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 118163011690 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 118163011691 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 118163011692 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 118163011693 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 118163011694 aromatic arch; other site 118163011695 DCoH dimer interaction site [polypeptide binding]; other site 118163011696 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 118163011697 DCoH tetramer interaction site [polypeptide binding]; other site 118163011698 substrate binding site [chemical binding]; other site 118163011699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011700 active site 118163011701 phosphorylation site [posttranslational modification] 118163011702 intermolecular recognition site; other site 118163011703 dimerization interface [polypeptide binding]; other site 118163011704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163011705 PAS domain; Region: PAS_9; pfam13426 118163011706 putative active site [active] 118163011707 heme pocket [chemical binding]; other site 118163011708 Response regulator receiver domain; Region: Response_reg; pfam00072 118163011709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011710 active site 118163011711 phosphorylation site [posttranslational modification] 118163011712 intermolecular recognition site; other site 118163011713 dimerization interface [polypeptide binding]; other site 118163011714 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163011715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163011716 active site 118163011717 substrate binding site [chemical binding]; other site 118163011718 ATP binding site [chemical binding]; other site 118163011719 activation loop (A-loop); other site 118163011720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 118163011721 AAA ATPase domain; Region: AAA_16; pfam13191 118163011722 Predicted ATPase [General function prediction only]; Region: COG3899 118163011723 Walker A motif; other site 118163011724 ATP binding site [chemical binding]; other site 118163011725 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163011726 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163011727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163011728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163011729 ATP binding site [chemical binding]; other site 118163011730 Mg2+ binding site [ion binding]; other site 118163011731 G-X-G motif; other site 118163011732 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 118163011733 active site 118163011734 dimer interface [polypeptide binding]; other site 118163011735 catalytic nucleophile [active] 118163011736 M28 Zn-Peptidases; Region: M28_like_1; cd05640 118163011737 Peptidase family M28; Region: Peptidase_M28; pfam04389 118163011738 metal binding site [ion binding]; metal-binding site 118163011739 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 118163011740 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 118163011741 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 118163011742 PsaD; Region: PsaD; pfam02531 118163011743 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 118163011744 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 118163011745 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 118163011746 protein binding site [polypeptide binding]; other site 118163011747 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 118163011748 Domain interface; other site 118163011749 Peptide binding site; other site 118163011750 Active site tetrad [active] 118163011751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163011752 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 118163011753 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 118163011754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 118163011755 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 118163011756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163011757 catalytic residue [active] 118163011758 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 118163011759 Methyltransferase domain; Region: Methyltransf_11; pfam08241 118163011760 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 118163011761 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 118163011762 Ligand binding site; other site 118163011763 Putative Catalytic site; other site 118163011764 DXD motif; other site 118163011765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163011766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 118163011767 putative substrate translocation pore; other site 118163011768 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 118163011769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163011770 NAD(P) binding site [chemical binding]; other site 118163011771 active site 118163011772 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 118163011773 substrate binding site [chemical binding]; other site 118163011774 active site 118163011775 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 118163011776 substrate binding site [chemical binding]; other site 118163011777 putative active site [active] 118163011778 redox center [active] 118163011779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 118163011780 Transposase IS200 like; Region: Y1_Tnp; pfam01797 118163011781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 118163011782 Probable transposase; Region: OrfB_IS605; pfam01385 118163011783 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 118163011784 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 118163011785 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 118163011786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163011787 FeS/SAM binding site; other site 118163011788 helicase 45; Provisional; Region: PTZ00424 118163011789 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 118163011790 ATP binding site [chemical binding]; other site 118163011791 Mg++ binding site [ion binding]; other site 118163011792 motif III; other site 118163011793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163011794 nucleotide binding region [chemical binding]; other site 118163011795 ATP-binding site [chemical binding]; other site 118163011796 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 118163011797 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 118163011798 domain interfaces; other site 118163011799 active site 118163011800 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163011801 putative active site [active] 118163011802 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 118163011803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163011804 Walker A/P-loop; other site 118163011805 ATP binding site [chemical binding]; other site 118163011806 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 118163011807 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 118163011808 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 118163011809 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 118163011810 16S rRNA methyltransferase B; Provisional; Region: PRK14901 118163011811 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 118163011812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163011813 S-adenosylmethionine binding site [chemical binding]; other site 118163011814 tellurium resistance terB-like protein; Region: terB_like; cd07177 118163011815 metal binding site [ion binding]; metal-binding site 118163011816 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 118163011817 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 118163011818 dimerization interface [polypeptide binding]; other site 118163011819 DPS ferroxidase diiron center [ion binding]; other site 118163011820 ion pore; other site 118163011821 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 118163011822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163011824 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 118163011825 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 118163011826 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 118163011827 DNA binding site [nucleotide binding] 118163011828 catalytic residue [active] 118163011829 H2TH interface [polypeptide binding]; other site 118163011830 putative catalytic residues [active] 118163011831 turnover-facilitating residue; other site 118163011832 intercalation triad [nucleotide binding]; other site 118163011833 8OG recognition residue [nucleotide binding]; other site 118163011834 putative reading head residues; other site 118163011835 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 118163011836 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 118163011837 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 118163011838 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 118163011839 colanic acid exporter; Provisional; Region: PRK10459 118163011840 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 118163011841 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163011842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163011843 active site 118163011844 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 118163011845 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 118163011846 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163011847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011848 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163011849 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163011850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011851 Haemagglutinin; Region: Hemagglutinin; pfam00509 118163011852 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 118163011853 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 118163011854 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 118163011855 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 118163011856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163011857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163011858 S-adenosylmethionine binding site [chemical binding]; other site 118163011859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 118163011860 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 118163011861 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 118163011862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163011863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011864 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 118163011865 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163011866 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 118163011867 metal-binding site 118163011868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163011869 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 118163011870 Methyltransferase domain; Region: Methyltransf_11; pfam08241 118163011871 Methyltransferase domain; Region: Methyltransf_23; pfam13489 118163011872 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 118163011873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 118163011874 active site 118163011875 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 118163011876 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 118163011877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163011878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163011879 S-adenosylmethionine binding site [chemical binding]; other site 118163011880 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 118163011881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163011882 ATP binding site [chemical binding]; other site 118163011883 putative Mg++ binding site [ion binding]; other site 118163011884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163011885 nucleotide binding region [chemical binding]; other site 118163011886 ATP-binding site [chemical binding]; other site 118163011887 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 118163011888 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 118163011889 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 118163011890 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 118163011891 SLBB domain; Region: SLBB; pfam10531 118163011892 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 118163011893 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 118163011894 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 118163011895 Nucleotide binding site [chemical binding]; other site 118163011896 DTAP/Switch II; other site 118163011897 Switch I; other site 118163011898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163011899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163011900 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 118163011901 Walker A/P-loop; other site 118163011902 ATP binding site [chemical binding]; other site 118163011903 Q-loop/lid; other site 118163011904 ABC transporter signature motif; other site 118163011905 Walker B; other site 118163011906 D-loop; other site 118163011907 H-loop/switch region; other site 118163011908 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 118163011909 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 118163011910 TrkA-N domain; Region: TrkA_N; pfam02254 118163011911 TrkA-C domain; Region: TrkA_C; pfam02080 118163011912 TrkA-C domain; Region: TrkA_C; pfam02080 118163011913 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 118163011914 ABC1 family; Region: ABC1; pfam03109 118163011915 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 118163011916 active site 118163011917 ATP binding site [chemical binding]; other site 118163011918 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 118163011919 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 118163011920 Substrate binding site; other site 118163011921 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 118163011922 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 118163011923 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 118163011924 putative NAD(P) binding site [chemical binding]; other site 118163011925 putative substrate binding site [chemical binding]; other site 118163011926 catalytic Zn binding site [ion binding]; other site 118163011927 structural Zn binding site [ion binding]; other site 118163011928 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 118163011929 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 118163011930 Walker A motif; other site 118163011931 ATP binding site [chemical binding]; other site 118163011932 Walker B motif; other site 118163011933 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 118163011934 ATP binding site [chemical binding]; other site 118163011935 Walker B motif; other site 118163011936 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 118163011937 tetramer interface [polypeptide binding]; other site 118163011938 dimer interface [polypeptide binding]; other site 118163011939 KaiA domain; Region: KaiA; pfam07688 118163011940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 118163011941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163011942 dimer interface [polypeptide binding]; other site 118163011943 phosphorylation site [posttranslational modification] 118163011944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163011945 ATP binding site [chemical binding]; other site 118163011946 Mg2+ binding site [ion binding]; other site 118163011947 G-X-G motif; other site 118163011948 Response regulator receiver domain; Region: Response_reg; pfam00072 118163011949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163011950 active site 118163011951 phosphorylation site [posttranslational modification] 118163011952 intermolecular recognition site; other site 118163011953 dimerization interface [polypeptide binding]; other site 118163011954 Exoribonuclease R [Transcription]; Region: VacB; COG0557 118163011955 RNB domain; Region: RNB; pfam00773 118163011956 ribosomal protein S18; Region: rps18; CHL00077 118163011957 ribosomal protein L33; Region: rpl33; CHL00104 118163011958 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 118163011959 S-layer homology domain; Region: SLH; pfam00395 118163011960 S-layer homology domain; Region: SLH; pfam00395 118163011961 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 118163011962 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 118163011963 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 118163011964 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 118163011965 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 118163011966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 118163011967 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 118163011968 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 118163011969 FAD binding domain; Region: FAD_binding_4; pfam01565 118163011970 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 118163011971 hypothetical protein; Validated; Region: PRK00153 118163011972 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 118163011973 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 118163011974 metal ion-dependent adhesion site (MIDAS); other site 118163011975 PRC-barrel domain; Region: PRC; pfam05239 118163011976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 118163011977 HSP70 interaction site [polypeptide binding]; other site 118163011978 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163011979 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011980 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163011981 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 118163011982 dimerization interface [polypeptide binding]; other site 118163011983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163011984 Ligand Binding Site [chemical binding]; other site 118163011985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 118163011986 Ligand Binding Site [chemical binding]; other site 118163011987 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 118163011988 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 118163011989 minor groove reading motif; other site 118163011990 helix-hairpin-helix signature motif; other site 118163011991 substrate binding pocket [chemical binding]; other site 118163011992 active site 118163011993 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 118163011994 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 118163011995 active site 118163011996 8-oxo-dGMP binding site [chemical binding]; other site 118163011997 nudix motif; other site 118163011998 metal binding site [ion binding]; metal-binding site 118163011999 Protein of unknown function (DUF760); Region: DUF760; pfam05542 118163012000 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 118163012001 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 118163012002 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 118163012003 Dimer interface [polypeptide binding]; other site 118163012004 BRCT sequence motif; other site 118163012005 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 118163012006 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 118163012007 catalytic triad [active] 118163012008 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 118163012009 homodimer interface [polypeptide binding]; other site 118163012010 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 118163012011 active site pocket [active] 118163012012 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 118163012013 putative active site [active] 118163012014 dimerization interface [polypeptide binding]; other site 118163012015 putative tRNAtyr binding site [nucleotide binding]; other site 118163012016 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 118163012017 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 118163012018 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 118163012019 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163012020 putative active site [active] 118163012021 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 118163012022 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 118163012023 active site 118163012024 HIGH motif; other site 118163012025 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 118163012026 KMSKS motif; other site 118163012027 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 118163012028 tRNA binding surface [nucleotide binding]; other site 118163012029 anticodon binding site; other site 118163012030 cobyric acid synthase; Provisional; Region: PRK00784 118163012031 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 118163012032 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 118163012033 catalytic triad [active] 118163012034 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 118163012035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 118163012036 catalytic triad [active] 118163012037 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 118163012038 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 118163012039 ketol-acid reductoisomerase; Provisional; Region: PRK05479 118163012040 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 118163012041 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 118163012042 hydrolase, alpha/beta fold family protein; Region: PLN02824 118163012043 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 118163012044 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 118163012045 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 118163012046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 118163012047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 118163012048 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 118163012049 dimer interface [polypeptide binding]; other site 118163012050 active site 118163012051 metal binding site [ion binding]; metal-binding site 118163012052 glutathione binding site [chemical binding]; other site 118163012053 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 118163012054 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 118163012055 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163012056 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163012057 active site 118163012058 ATP binding site [chemical binding]; other site 118163012059 substrate binding site [chemical binding]; other site 118163012060 activation loop (A-loop); other site 118163012061 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 118163012062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 118163012063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 118163012064 active site 118163012065 catalytic tetrad [active] 118163012066 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 118163012067 serpin-like protein; Provisional; Region: PHA02660 118163012068 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 118163012069 reactive center loop; other site 118163012070 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 118163012071 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 118163012072 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 118163012073 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 118163012074 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 118163012075 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 118163012076 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 118163012077 Cl- selectivity filter; other site 118163012078 Cl- binding residues [ion binding]; other site 118163012079 pore gating glutamate residue; other site 118163012080 dimer interface [polypeptide binding]; other site 118163012081 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 118163012082 FOG: CBS domain [General function prediction only]; Region: COG0517 118163012083 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 118163012084 Response regulator receiver domain; Region: Response_reg; pfam00072 118163012085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012086 active site 118163012087 phosphorylation site [posttranslational modification] 118163012088 intermolecular recognition site; other site 118163012089 dimerization interface [polypeptide binding]; other site 118163012090 hypothetical protein; Validated; Region: PRK00029 118163012091 Uncharacterized conserved protein [Function unknown]; Region: COG0397 118163012092 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 118163012093 Methyltransferase domain; Region: Methyltransf_31; pfam13847 118163012094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163012095 S-adenosylmethionine binding site [chemical binding]; other site 118163012096 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 118163012097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163012098 NAD(P) binding site [chemical binding]; other site 118163012099 active site 118163012100 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 118163012101 Double zinc ribbon; Region: DZR; pfam12773 118163012102 Protein phosphatase 2C; Region: PP2C; pfam00481 118163012103 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 118163012104 active site 118163012105 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 118163012106 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 118163012107 phosphopeptide binding site; other site 118163012108 Protein kinase domain; Region: Pkinase; pfam00069 118163012109 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163012110 active site 118163012111 ATP binding site [chemical binding]; other site 118163012112 substrate binding site [chemical binding]; other site 118163012113 activation loop (A-loop); other site 118163012114 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 118163012115 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 118163012116 feedback inhibition sensing region; other site 118163012117 homohexameric interface [polypeptide binding]; other site 118163012118 nucleotide binding site [chemical binding]; other site 118163012119 N-acetyl-L-glutamate binding site [chemical binding]; other site 118163012120 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 118163012121 Protein of unknown function (DUF561); Region: DUF561; pfam04481 118163012122 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 118163012123 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 118163012124 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163012125 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 118163012126 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 118163012127 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 118163012128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 118163012129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 118163012130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 118163012131 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 118163012132 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 118163012133 Phycobilisome protein; Region: Phycobilisome; cl08227 118163012134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163012135 TPR motif; other site 118163012136 TPR repeat; Region: TPR_11; pfam13414 118163012137 binding surface 118163012138 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 118163012139 nitrilase; Region: PLN02798 118163012140 putative active site [active] 118163012141 catalytic triad [active] 118163012142 dimer interface [polypeptide binding]; other site 118163012143 Haemolytic domain; Region: Haemolytic; pfam01809 118163012144 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 118163012145 ATP-NAD kinase; Region: NAD_kinase; pfam01513 118163012146 GTPase CgtA; Reviewed; Region: obgE; PRK12299 118163012147 GTP1/OBG; Region: GTP1_OBG; pfam01018 118163012148 Obg GTPase; Region: Obg; cd01898 118163012149 G1 box; other site 118163012150 GTP/Mg2+ binding site [chemical binding]; other site 118163012151 Switch I region; other site 118163012152 G2 box; other site 118163012153 G3 box; other site 118163012154 Switch II region; other site 118163012155 G4 box; other site 118163012156 G5 box; other site 118163012157 tellurium resistance terB-like protein; Region: terB_like; cd07177 118163012158 metal binding site [ion binding]; metal-binding site 118163012159 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 118163012160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 118163012161 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 118163012162 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 118163012163 Sporulation and spore germination; Region: Germane; pfam10646 118163012164 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 118163012165 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 118163012166 carboxyltransferase (CT) interaction site; other site 118163012167 biotinylation site [posttranslational modification]; other site 118163012168 elongation factor P; Validated; Region: PRK00529 118163012169 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 118163012170 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 118163012171 RNA binding site [nucleotide binding]; other site 118163012172 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 118163012173 RNA binding site [nucleotide binding]; other site 118163012174 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 118163012175 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 118163012176 [2Fe-2S] cluster binding site [ion binding]; other site 118163012177 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 118163012178 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 118163012179 active site 118163012180 thiamine monophosphate kinase; Provisional; Region: PRK05731 118163012181 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 118163012182 ATP binding site [chemical binding]; other site 118163012183 dimerization interface [polypeptide binding]; other site 118163012184 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 118163012185 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 118163012186 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 118163012187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163012188 catalytic loop [active] 118163012189 iron binding site [ion binding]; other site 118163012190 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 118163012191 CAAX protease self-immunity; Region: Abi; pfam02517 118163012192 Circadian oscillating protein COP23; Region: COP23; pfam14218 118163012193 hypothetical protein; Provisional; Region: PRK09936 118163012194 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 118163012195 conserved cys residue [active] 118163012196 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 118163012197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163012198 ATP binding site [chemical binding]; other site 118163012199 putative Mg++ binding site [ion binding]; other site 118163012200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163012201 nucleotide binding region [chemical binding]; other site 118163012202 ATP-binding site [chemical binding]; other site 118163012203 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 118163012204 Response regulator receiver domain; Region: Response_reg; pfam00072 118163012205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012206 active site 118163012207 intermolecular recognition site; other site 118163012208 dimerization interface [polypeptide binding]; other site 118163012209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 118163012210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 118163012211 metal binding site [ion binding]; metal-binding site 118163012212 active site 118163012213 I-site; other site 118163012214 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 118163012215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 118163012216 Walker A motif; other site 118163012217 ATP binding site [chemical binding]; other site 118163012218 Walker B motif; other site 118163012219 arginine finger; other site 118163012220 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 118163012221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 118163012222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 118163012223 S-adenosylmethionine binding site [chemical binding]; other site 118163012224 FOG: CBS domain [General function prediction only]; Region: COG0517 118163012225 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 118163012226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012227 putative active site [active] 118163012228 PAS fold; Region: PAS_3; pfam08447 118163012229 heme pocket [chemical binding]; other site 118163012230 PAS domain S-box; Region: sensory_box; TIGR00229 118163012231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012232 putative active site [active] 118163012233 heme pocket [chemical binding]; other site 118163012234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012235 PAS fold; Region: PAS_3; pfam08447 118163012236 putative active site [active] 118163012237 heme pocket [chemical binding]; other site 118163012238 PAS domain S-box; Region: sensory_box; TIGR00229 118163012239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012240 putative active site [active] 118163012241 heme pocket [chemical binding]; other site 118163012242 PAS domain S-box; Region: sensory_box; TIGR00229 118163012243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012244 putative active site [active] 118163012245 heme pocket [chemical binding]; other site 118163012246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012247 PAS fold; Region: PAS_3; pfam08447 118163012248 putative active site [active] 118163012249 heme pocket [chemical binding]; other site 118163012250 GAF domain; Region: GAF; pfam01590 118163012251 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 118163012252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 118163012253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163012254 dimer interface [polypeptide binding]; other site 118163012255 phosphorylation site [posttranslational modification] 118163012256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163012257 ATP binding site [chemical binding]; other site 118163012258 Mg2+ binding site [ion binding]; other site 118163012259 G-X-G motif; other site 118163012260 Response regulator receiver domain; Region: Response_reg; pfam00072 118163012261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012262 active site 118163012263 phosphorylation site [posttranslational modification] 118163012264 intermolecular recognition site; other site 118163012265 dimerization interface [polypeptide binding]; other site 118163012266 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163012267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012268 active site 118163012269 phosphorylation site [posttranslational modification] 118163012270 intermolecular recognition site; other site 118163012271 dimerization interface [polypeptide binding]; other site 118163012272 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 118163012273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012274 putative active site [active] 118163012275 heme pocket [chemical binding]; other site 118163012276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012277 putative active site [active] 118163012278 heme pocket [chemical binding]; other site 118163012279 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 118163012280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 118163012281 putative active site [active] 118163012282 heme pocket [chemical binding]; other site 118163012283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 118163012284 dimer interface [polypeptide binding]; other site 118163012285 phosphorylation site [posttranslational modification] 118163012286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 118163012287 ATP binding site [chemical binding]; other site 118163012288 Mg2+ binding site [ion binding]; other site 118163012289 G-X-G motif; other site 118163012290 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 118163012291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012292 active site 118163012293 phosphorylation site [posttranslational modification] 118163012294 intermolecular recognition site; other site 118163012295 dimerization interface [polypeptide binding]; other site 118163012296 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 118163012297 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 118163012298 allophycocyanin beta subunit; Region: apcB; CHL00088 118163012299 Phycobilisome protein; Region: Phycobilisome; cl08227 118163012300 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 118163012301 putative active site [active] 118163012302 phycobillisome linker protein; Region: apcE; CHL00091 118163012303 Phycobilisome protein; Region: Phycobilisome; cl08227 118163012304 Phycobilisome protein; Region: Phycobilisome; cl08227 118163012305 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163012306 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163012307 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 118163012308 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012309 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012310 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012311 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012312 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012313 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 118163012314 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 118163012315 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 118163012316 catalytic triad [active] 118163012317 putative active site [active] 118163012318 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 118163012319 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 118163012320 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 118163012321 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 118163012322 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 118163012323 cytochrome b subunit interaction site [polypeptide binding]; other site 118163012324 [2Fe-2S] cluster binding site [ion binding]; other site 118163012325 apocytochrome f; Reviewed; Region: PRK02693 118163012326 cytochrome f; Region: petA; CHL00037 118163012327 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 118163012328 metal binding site 2 [ion binding]; metal-binding site 118163012329 putative DNA binding helix; other site 118163012330 metal binding site 1 [ion binding]; metal-binding site 118163012331 dimer interface [polypeptide binding]; other site 118163012332 structural Zn2+ binding site [ion binding]; other site 118163012333 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 118163012334 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 118163012335 Cupin domain; Region: Cupin_2; cl17218 118163012336 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 118163012337 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 118163012338 P loop; other site 118163012339 Nucleotide binding site [chemical binding]; other site 118163012340 DTAP/Switch II; other site 118163012341 Switch I; other site 118163012342 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 118163012343 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 118163012344 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 118163012345 active site 118163012346 homodimer interface [polypeptide binding]; other site 118163012347 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 118163012348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 118163012349 Walker A/P-loop; other site 118163012350 ATP binding site [chemical binding]; other site 118163012351 Q-loop/lid; other site 118163012352 ABC transporter signature motif; other site 118163012353 Walker B; other site 118163012354 D-loop; other site 118163012355 H-loop/switch region; other site 118163012356 TOBE domain; Region: TOBE_2; pfam08402 118163012357 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 118163012358 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 118163012359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 118163012360 putative DNA binding site [nucleotide binding]; other site 118163012361 putative Zn2+ binding site [ion binding]; other site 118163012362 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 118163012363 putative ABC transporter; Region: ycf24; CHL00085 118163012364 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 118163012365 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 118163012366 Walker A/P-loop; other site 118163012367 ATP binding site [chemical binding]; other site 118163012368 Q-loop/lid; other site 118163012369 ABC transporter signature motif; other site 118163012370 Walker B; other site 118163012371 D-loop; other site 118163012372 H-loop/switch region; other site 118163012373 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 118163012374 FeS assembly protein SufD; Region: sufD; TIGR01981 118163012375 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 118163012376 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 118163012377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 118163012378 catalytic residue [active] 118163012379 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 118163012380 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 118163012381 NADH(P)-binding; Region: NAD_binding_10; pfam13460 118163012382 NAD(P) binding site [chemical binding]; other site 118163012383 putative active site [active] 118163012384 BioY family; Region: BioY; pfam02632 118163012385 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 118163012386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 118163012387 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 118163012388 H+ Antiporter protein; Region: 2A0121; TIGR00900 118163012389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 118163012390 putative substrate translocation pore; other site 118163012391 Protein of unknown function (DUF3989); Region: DUF3989; pfam13150 118163012392 RDD family; Region: RDD; pfam06271 118163012393 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163012394 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012395 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012396 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163012397 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012398 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012399 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 118163012400 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 118163012401 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 118163012402 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 118163012403 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 118163012404 G1 box; other site 118163012405 putative GEF interaction site [polypeptide binding]; other site 118163012406 GTP/Mg2+ binding site [chemical binding]; other site 118163012407 Switch I region; other site 118163012408 G2 box; other site 118163012409 G3 box; other site 118163012410 Switch II region; other site 118163012411 G4 box; other site 118163012412 G5 box; other site 118163012413 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 118163012414 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 118163012415 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 118163012416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 118163012417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163012418 homodimer interface [polypeptide binding]; other site 118163012419 catalytic residue [active] 118163012420 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 118163012421 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 118163012422 active site 118163012423 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 118163012424 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 118163012425 aromatic acid decarboxylase; Validated; Region: PRK05920 118163012426 Flavoprotein; Region: Flavoprotein; pfam02441 118163012427 HEAT repeats; Region: HEAT_2; pfam13646 118163012428 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 118163012429 HEAT repeats; Region: HEAT_2; pfam13646 118163012430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 118163012431 Coenzyme A binding pocket [chemical binding]; other site 118163012432 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 118163012433 Transposase IS200 like; Region: Y1_Tnp; cl00848 118163012434 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 118163012435 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 118163012436 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 118163012437 substrate-cofactor binding pocket; other site 118163012438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 118163012439 catalytic residue [active] 118163012440 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 118163012441 RimM N-terminal domain; Region: RimM; pfam01782 118163012442 PRC-barrel domain; Region: PRC; pfam05239 118163012443 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 118163012444 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 118163012445 ATP adenylyltransferase; Region: ATP_transf; pfam09830 118163012446 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 118163012447 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 118163012448 catalytic loop [active] 118163012449 iron binding site [ion binding]; other site 118163012450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 118163012451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 118163012452 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 118163012453 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 118163012454 homodimer interface [polypeptide binding]; other site 118163012455 oligonucleotide binding site [chemical binding]; other site 118163012456 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 118163012457 RNA/DNA hybrid binding site [nucleotide binding]; other site 118163012458 active site 118163012459 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 118163012460 prephenate dehydratase; Provisional; Region: PRK11898 118163012461 Prephenate dehydratase; Region: PDT; pfam00800 118163012462 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 118163012463 putative L-Phe binding site [chemical binding]; other site 118163012464 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 118163012465 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 118163012466 active site 118163012467 catalytic site [active] 118163012468 substrate binding site [chemical binding]; other site 118163012469 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 118163012470 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 118163012471 active site 118163012472 substrate-binding site [chemical binding]; other site 118163012473 metal-binding site [ion binding] 118163012474 ATP binding site [chemical binding]; other site 118163012475 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 118163012476 heme-binding site [chemical binding]; other site 118163012477 Stage II sporulation protein; Region: SpoIID; pfam08486 118163012478 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 118163012479 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 118163012480 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 118163012481 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 118163012482 ParB-like nuclease domain; Region: ParBc; cl02129 118163012483 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 118163012484 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 118163012485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 118163012486 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 118163012487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 118163012488 DNA binding residues [nucleotide binding] 118163012489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 118163012490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 118163012491 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 118163012492 Walker A/P-loop; other site 118163012493 ATP binding site [chemical binding]; other site 118163012494 Q-loop/lid; other site 118163012495 ABC transporter signature motif; other site 118163012496 Walker B; other site 118163012497 D-loop; other site 118163012498 H-loop/switch region; other site 118163012499 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 118163012500 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 118163012501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012502 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163012503 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012504 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 118163012505 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 118163012506 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 118163012507 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 118163012508 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 118163012509 FAD binding domain; Region: FAD_binding_4; pfam01565 118163012510 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 118163012511 5-oxoprolinase; Region: PLN02666 118163012512 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 118163012513 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 118163012514 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 118163012515 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 118163012516 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 118163012517 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 118163012518 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 118163012519 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163012520 P-loop; other site 118163012521 Magnesium ion binding site [ion binding]; other site 118163012522 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 118163012523 Magnesium ion binding site [ion binding]; other site 118163012524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 118163012525 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 118163012526 NAD(P) binding site [chemical binding]; other site 118163012527 active site 118163012528 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 118163012529 Glucose inhibited division protein A; Region: GIDA; pfam01134 118163012530 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 118163012531 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 118163012532 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 118163012533 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 118163012534 active site 118163012535 metal binding site [ion binding]; metal-binding site 118163012536 DNA binding site [nucleotide binding] 118163012537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163012538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163012539 active site 118163012540 ATP binding site [chemical binding]; other site 118163012541 substrate binding site [chemical binding]; other site 118163012542 activation loop (A-loop); other site 118163012543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 118163012544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 118163012545 active site 118163012546 ATP binding site [chemical binding]; other site 118163012547 substrate binding site [chemical binding]; other site 118163012548 activation loop (A-loop); other site 118163012549 TPR repeat; Region: TPR_11; pfam13414 118163012550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163012551 binding surface 118163012552 TPR motif; other site 118163012553 TPR repeat; Region: TPR_11; pfam13414 118163012554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163012555 binding surface 118163012556 TPR repeat; Region: TPR_11; pfam13414 118163012557 TPR motif; other site 118163012558 TPR repeat; Region: TPR_11; pfam13414 118163012559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 118163012560 binding surface 118163012561 TPR motif; other site 118163012562 TPR repeat; Region: TPR_11; pfam13414 118163012563 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 118163012564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 118163012565 ATP binding site [chemical binding]; other site 118163012566 putative Mg++ binding site [ion binding]; other site 118163012567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 118163012568 nucleotide binding region [chemical binding]; other site 118163012569 ATP-binding site [chemical binding]; other site 118163012570 PetN; Region: PetN; pfam03742 118163012571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 118163012572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 118163012573 active site 118163012574 phosphorylation site [posttranslational modification] 118163012575 intermolecular recognition site; other site 118163012576 dimerization interface [polypeptide binding]; other site 118163012577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 118163012578 DNA binding residues [nucleotide binding] 118163012579 dimerization interface [polypeptide binding]; other site 118163012580 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 118163012581 intersubunit interface [polypeptide binding]; other site 118163012582 active site 118163012583 zinc binding site [ion binding]; other site 118163012584 Na+ binding site [ion binding]; other site 118163012585 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 118163012586 active site 118163012587 SAM binding site [chemical binding]; other site 118163012588 homodimer interface [polypeptide binding]; other site 118163012589 phosphoglycolate phosphatase; Provisional; Region: PRK13225 118163012590 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 118163012591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 118163012592 Protein of unknown function (DUF433); Region: DUF433; cl01030 118163012593 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 118163012594 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 118163012595 active site 118163012596 dimer interface [polypeptide binding]; other site 118163012597 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 118163012598 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 118163012599 active site 118163012600 FMN binding site [chemical binding]; other site 118163012601 substrate binding site [chemical binding]; other site 118163012602 3Fe-4S cluster binding site [ion binding]; other site 118163012603 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 118163012604 domain interface; other site 118163012605 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 118163012606 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 118163012607 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 118163012608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 118163012609 dimer interface [polypeptide binding]; other site 118163012610 conserved gate region; other site 118163012611 putative PBP binding loops; other site 118163012612 ABC-ATPase subunit interface; other site 118163012613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 118163012614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 118163012615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 118163012616 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 118163012617 TPP-binding site [chemical binding]; other site 118163012618 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 118163012619 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 118163012620 PYR/PP interface [polypeptide binding]; other site 118163012621 dimer interface [polypeptide binding]; other site 118163012622 TPP binding site [chemical binding]; other site 118163012623 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 118163012624 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 118163012625 classical (c) SDRs; Region: SDR_c; cd05233 118163012626 NAD(P) binding site [chemical binding]; other site 118163012627 active site 118163012628 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 118163012629 Fasciclin domain; Region: Fasciclin; pfam02469 118163012630 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 118163012631 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 118163012632 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 118163012633 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 118163012634 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 118163012635 Hexamer interface [polypeptide binding]; other site 118163012636 Hexagonal pore residue; other site 118163012637 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 118163012638 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 118163012639 B12 binding site [chemical binding]; other site 118163012640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 118163012641 FeS/SAM binding site; other site 118163012642 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 118163012643 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 118163012644 putative hydrophobic ligand binding site [chemical binding]; other site 118163012645 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 118163012646 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 118163012647 DXD motif; other site 118163012648 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 118163012649 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 118163012650 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 118163012651 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 118163012652 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 118163012653 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 118163012654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 118163012655 nucleotide binding site [chemical binding]; other site 118163012656 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 118163012657 active site 118163012658 catalytic residues [active] 118163012659 metal binding site [ion binding]; metal-binding site