-- dump date 20140619_235031 -- class Genbank::misc_feature -- table misc_feature_note -- id note 312153000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 312153000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 312153000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153000004 Walker A motif; other site 312153000005 ATP binding site [chemical binding]; other site 312153000006 Walker B motif; other site 312153000007 arginine finger; other site 312153000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 312153000009 DnaA box-binding interface [nucleotide binding]; other site 312153000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 312153000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 312153000012 putative DNA binding surface [nucleotide binding]; other site 312153000013 dimer interface [polypeptide binding]; other site 312153000014 beta-clamp/clamp loader binding surface; other site 312153000015 beta-clamp/translesion DNA polymerase binding surface; other site 312153000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 312153000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153000018 ATP binding site [chemical binding]; other site 312153000019 Mg2+ binding site [ion binding]; other site 312153000020 G-X-G motif; other site 312153000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 312153000022 anchoring element; other site 312153000023 dimer interface [polypeptide binding]; other site 312153000024 ATP binding site [chemical binding]; other site 312153000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 312153000026 active site 312153000027 putative metal-binding site [ion binding]; other site 312153000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 312153000029 Proteins containing SET domain [General function prediction only]; Region: COG2940 312153000030 SET domain; Region: SET; pfam00856 312153000031 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 312153000032 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 312153000033 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 312153000034 Walker A/P-loop; other site 312153000035 ATP binding site [chemical binding]; other site 312153000036 Q-loop/lid; other site 312153000037 ABC transporter signature motif; other site 312153000038 Walker B; other site 312153000039 D-loop; other site 312153000040 H-loop/switch region; other site 312153000041 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 312153000042 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 312153000043 Walker A/P-loop; other site 312153000044 ATP binding site [chemical binding]; other site 312153000045 Q-loop/lid; other site 312153000046 ABC transporter signature motif; other site 312153000047 Walker B; other site 312153000048 D-loop; other site 312153000049 H-loop/switch region; other site 312153000050 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 312153000051 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 312153000052 putative ligand binding site [chemical binding]; other site 312153000053 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 312153000054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 312153000055 TM-ABC transporter signature motif; other site 312153000056 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 312153000057 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 312153000058 TM-ABC transporter signature motif; other site 312153000059 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 312153000060 putative active site [active] 312153000061 putative substrate binding site [chemical binding]; other site 312153000062 ATP binding site [chemical binding]; other site 312153000063 short chain dehydrogenase; Provisional; Region: PRK06949 312153000064 classical (c) SDRs; Region: SDR_c; cd05233 312153000065 NAD(P) binding site [chemical binding]; other site 312153000066 active site 312153000067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 312153000068 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 312153000069 active site 312153000070 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153000071 hypothetical protein; Provisional; Region: PRK10621 312153000072 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 312153000073 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 312153000074 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 312153000075 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 312153000076 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 312153000077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153000078 S-adenosylmethionine binding site [chemical binding]; other site 312153000079 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 312153000080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 312153000081 P-loop; other site 312153000082 Magnesium ion binding site [ion binding]; other site 312153000083 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 312153000084 ParB-like nuclease domain; Region: ParBc; pfam02195 312153000085 ATP synthase I chain; Region: ATP_synt_I; pfam03899 312153000086 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 312153000087 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 312153000088 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 312153000089 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 312153000090 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 312153000091 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 312153000092 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 312153000093 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 312153000094 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 312153000095 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 312153000096 beta subunit interaction interface [polypeptide binding]; other site 312153000097 Walker A motif; other site 312153000098 ATP binding site [chemical binding]; other site 312153000099 Walker B motif; other site 312153000100 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 312153000101 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 312153000102 core domain interface [polypeptide binding]; other site 312153000103 delta subunit interface [polypeptide binding]; other site 312153000104 epsilon subunit interface [polypeptide binding]; other site 312153000105 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 312153000106 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 312153000107 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 312153000108 alpha subunit interaction interface [polypeptide binding]; other site 312153000109 Walker A motif; other site 312153000110 ATP binding site [chemical binding]; other site 312153000111 Walker B motif; other site 312153000112 inhibitor binding site; inhibition site 312153000113 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 312153000114 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 312153000115 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 312153000116 gamma subunit interface [polypeptide binding]; other site 312153000117 epsilon subunit interface [polypeptide binding]; other site 312153000118 LBP interface [polypeptide binding]; other site 312153000119 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 312153000120 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 312153000121 substrate binding site [chemical binding]; other site 312153000122 active site 312153000123 primosome assembly protein PriA; Validated; Region: PRK05580 312153000124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153000125 ATP binding site [chemical binding]; other site 312153000126 putative Mg++ binding site [ion binding]; other site 312153000127 helicase superfamily c-terminal domain; Region: HELICc; smart00490 312153000128 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 312153000129 lipoyl attachment site [posttranslational modification]; other site 312153000130 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 312153000131 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 312153000132 Fatty acid desaturase; Region: FA_desaturase; pfam00487 312153000133 putative di-iron ligands [ion binding]; other site 312153000134 Cytochrome c; Region: Cytochrom_C; cl11414 312153000135 Predicted methyltransferases [General function prediction only]; Region: COG0313 312153000136 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 312153000137 putative SAM binding site [chemical binding]; other site 312153000138 putative homodimer interface [polypeptide binding]; other site 312153000139 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 312153000140 dimer interface [polypeptide binding]; other site 312153000141 active site 312153000142 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 312153000143 BON domain; Region: BON; pfam04972 312153000144 BON domain; Region: BON; pfam04972 312153000145 Cytochrome c; Region: Cytochrom_C; cl11414 312153000146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 312153000147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153000148 Coenzyme A binding pocket [chemical binding]; other site 312153000149 elongation factor Tu; Reviewed; Region: PRK00049 312153000150 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 312153000151 G1 box; other site 312153000152 GEF interaction site [polypeptide binding]; other site 312153000153 GTP/Mg2+ binding site [chemical binding]; other site 312153000154 Switch I region; other site 312153000155 G2 box; other site 312153000156 G3 box; other site 312153000157 Switch II region; other site 312153000158 G4 box; other site 312153000159 G5 box; other site 312153000160 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 312153000161 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 312153000162 Antibiotic Binding Site [chemical binding]; other site 312153000163 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 312153000164 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 312153000165 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 312153000166 putative homodimer interface [polypeptide binding]; other site 312153000167 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 312153000168 heterodimer interface [polypeptide binding]; other site 312153000169 homodimer interface [polypeptide binding]; other site 312153000170 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 312153000171 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 312153000172 23S rRNA interface [nucleotide binding]; other site 312153000173 L7/L12 interface [polypeptide binding]; other site 312153000174 putative thiostrepton binding site; other site 312153000175 L25 interface [polypeptide binding]; other site 312153000176 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 312153000177 mRNA/rRNA interface [nucleotide binding]; other site 312153000178 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 312153000179 23S rRNA interface [nucleotide binding]; other site 312153000180 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 312153000181 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 312153000182 core dimer interface [polypeptide binding]; other site 312153000183 peripheral dimer interface [polypeptide binding]; other site 312153000184 L10 interface [polypeptide binding]; other site 312153000185 L11 interface [polypeptide binding]; other site 312153000186 putative EF-Tu interaction site [polypeptide binding]; other site 312153000187 putative EF-G interaction site [polypeptide binding]; other site 312153000188 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 312153000189 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 312153000190 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 312153000191 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 312153000192 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 312153000193 RPB3 interaction site [polypeptide binding]; other site 312153000194 RPB1 interaction site [polypeptide binding]; other site 312153000195 RPB11 interaction site [polypeptide binding]; other site 312153000196 RPB10 interaction site [polypeptide binding]; other site 312153000197 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 312153000198 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 312153000199 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 312153000200 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 312153000201 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 312153000202 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 312153000203 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 312153000204 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 312153000205 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 312153000206 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 312153000207 DNA binding site [nucleotide binding] 312153000208 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 312153000209 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 312153000210 S17 interaction site [polypeptide binding]; other site 312153000211 S8 interaction site; other site 312153000212 16S rRNA interaction site [nucleotide binding]; other site 312153000213 streptomycin interaction site [chemical binding]; other site 312153000214 23S rRNA interaction site [nucleotide binding]; other site 312153000215 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 312153000216 30S ribosomal protein S7; Validated; Region: PRK05302 312153000217 elongation factor G; Reviewed; Region: PRK00007 312153000218 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 312153000219 G1 box; other site 312153000220 putative GEF interaction site [polypeptide binding]; other site 312153000221 GTP/Mg2+ binding site [chemical binding]; other site 312153000222 Switch I region; other site 312153000223 G2 box; other site 312153000224 G3 box; other site 312153000225 Switch II region; other site 312153000226 G4 box; other site 312153000227 G5 box; other site 312153000228 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 312153000229 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 312153000230 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 312153000231 elongation factor Tu; Reviewed; Region: PRK00049 312153000232 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 312153000233 G1 box; other site 312153000234 GEF interaction site [polypeptide binding]; other site 312153000235 GTP/Mg2+ binding site [chemical binding]; other site 312153000236 Switch I region; other site 312153000237 G2 box; other site 312153000238 G3 box; other site 312153000239 Switch II region; other site 312153000240 G4 box; other site 312153000241 G5 box; other site 312153000242 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 312153000243 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 312153000244 Antibiotic Binding Site [chemical binding]; other site 312153000245 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 312153000246 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 312153000247 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 312153000248 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 312153000249 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 312153000250 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 312153000251 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 312153000252 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 312153000253 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 312153000254 putative translocon binding site; other site 312153000255 protein-rRNA interface [nucleotide binding]; other site 312153000256 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 312153000257 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 312153000258 G-X-X-G motif; other site 312153000259 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 312153000260 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 312153000261 23S rRNA interface [nucleotide binding]; other site 312153000262 5S rRNA interface [nucleotide binding]; other site 312153000263 putative antibiotic binding site [chemical binding]; other site 312153000264 L25 interface [polypeptide binding]; other site 312153000265 L27 interface [polypeptide binding]; other site 312153000266 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 312153000267 L23 interface [polypeptide binding]; other site 312153000268 signal recognition particle (SRP54) interaction site; other site 312153000269 trigger factor interaction site; other site 312153000270 23S rRNA interface [nucleotide binding]; other site 312153000271 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 312153000272 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 312153000273 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 312153000274 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 312153000275 RNA binding site [nucleotide binding]; other site 312153000276 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 312153000277 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 312153000278 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 312153000279 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 312153000280 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 312153000281 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 312153000282 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 312153000283 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 312153000284 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 312153000285 5S rRNA interface [nucleotide binding]; other site 312153000286 23S rRNA interface [nucleotide binding]; other site 312153000287 L5 interface [polypeptide binding]; other site 312153000288 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 312153000289 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 312153000290 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 312153000291 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 312153000292 23S rRNA binding site [nucleotide binding]; other site 312153000293 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 312153000294 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 312153000295 SecY translocase; Region: SecY; pfam00344 312153000296 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 312153000297 rRNA binding site [nucleotide binding]; other site 312153000298 predicted 30S ribosome binding site; other site 312153000299 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 312153000300 30S ribosomal protein S13; Region: bact_S13; TIGR03631 312153000301 30S ribosomal protein S11; Validated; Region: PRK05309 312153000302 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 312153000303 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 312153000304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153000305 RNA binding surface [nucleotide binding]; other site 312153000306 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 312153000307 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 312153000308 alphaNTD homodimer interface [polypeptide binding]; other site 312153000309 alphaNTD - beta interaction site [polypeptide binding]; other site 312153000310 alphaNTD - beta' interaction site [polypeptide binding]; other site 312153000311 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 312153000312 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 312153000313 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 312153000314 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 312153000315 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 312153000316 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 312153000317 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 312153000318 DsbD alpha interface [polypeptide binding]; other site 312153000319 catalytic residues [active] 312153000320 MOSC domain; Region: MOSC; pfam03473 312153000321 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 312153000322 dimer interface [polypeptide binding]; other site 312153000323 active site 312153000324 aspartate-rich active site metal binding site; other site 312153000325 allosteric magnesium binding site [ion binding]; other site 312153000326 Schiff base residues; other site 312153000327 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 312153000328 G1 box; other site 312153000329 GTP/Mg2+ binding site [chemical binding]; other site 312153000330 Switch I region; other site 312153000331 G2 box; other site 312153000332 G3 box; other site 312153000333 Switch II region; other site 312153000334 G4 box; other site 312153000335 G5 box; other site 312153000336 Cytochrome c553 [Energy production and conversion]; Region: COG2863 312153000337 Cytochrome c; Region: Cytochrom_C; cl11414 312153000338 diaminopimelate decarboxylase; Region: lysA; TIGR01048 312153000339 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 312153000340 active site 312153000341 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 312153000342 substrate binding site [chemical binding]; other site 312153000343 catalytic residues [active] 312153000344 dimer interface [polypeptide binding]; other site 312153000345 Frataxin-like domain; Region: Frataxin_Cyay; pfam01491 312153000346 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 312153000347 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 312153000348 active site 312153000349 dimer interface [polypeptide binding]; other site 312153000350 metal binding site [ion binding]; metal-binding site 312153000351 shikimate kinase; Reviewed; Region: aroK; PRK00131 312153000352 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 312153000353 ADP binding site [chemical binding]; other site 312153000354 magnesium binding site [ion binding]; other site 312153000355 putative shikimate binding site; other site 312153000356 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 312153000357 Secretin and TonB N terminus short domain; Region: STN; pfam07660 312153000358 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 312153000359 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 312153000360 Transglycosylase; Region: Transgly; pfam00912 312153000361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 312153000362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 312153000363 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 312153000364 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 312153000365 active site 312153000366 dimer interface [polypeptide binding]; other site 312153000367 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 312153000368 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 312153000369 active site 312153000370 FMN binding site [chemical binding]; other site 312153000371 substrate binding site [chemical binding]; other site 312153000372 3Fe-4S cluster binding site [ion binding]; other site 312153000373 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 312153000374 domain interface; other site 312153000375 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 312153000376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153000377 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 312153000378 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 312153000379 Walker A/P-loop; other site 312153000380 ATP binding site [chemical binding]; other site 312153000381 Q-loop/lid; other site 312153000382 ABC transporter signature motif; other site 312153000383 Walker B; other site 312153000384 D-loop; other site 312153000385 H-loop/switch region; other site 312153000386 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 312153000387 Permease; Region: Permease; pfam02405 312153000388 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 312153000389 mce related protein; Region: MCE; pfam02470 312153000390 VacJ like lipoprotein; Region: VacJ; cl01073 312153000391 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 312153000392 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 312153000393 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 312153000394 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 312153000395 Walker A/P-loop; other site 312153000396 ATP binding site [chemical binding]; other site 312153000397 Q-loop/lid; other site 312153000398 ABC transporter signature motif; other site 312153000399 Walker B; other site 312153000400 D-loop; other site 312153000401 H-loop/switch region; other site 312153000402 ABC-2 type transporter; Region: ABC2_membrane; cl17235 312153000403 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 312153000404 BolA-like protein; Region: BolA; pfam01722 312153000405 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 312153000406 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 312153000407 hinge; other site 312153000408 active site 312153000409 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 312153000410 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 312153000411 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 312153000412 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 312153000413 NAD binding site [chemical binding]; other site 312153000414 dimerization interface [polypeptide binding]; other site 312153000415 product binding site; other site 312153000416 substrate binding site [chemical binding]; other site 312153000417 zinc binding site [ion binding]; other site 312153000418 catalytic residues [active] 312153000419 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 312153000420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153000421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153000422 homodimer interface [polypeptide binding]; other site 312153000423 catalytic residue [active] 312153000424 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 312153000425 putative active site pocket [active] 312153000426 4-fold oligomerization interface [polypeptide binding]; other site 312153000427 metal binding residues [ion binding]; metal-binding site 312153000428 3-fold/trimer interface [polypeptide binding]; other site 312153000429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 312153000430 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 312153000431 putative active site [active] 312153000432 oxyanion strand; other site 312153000433 catalytic triad [active] 312153000434 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 312153000435 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 312153000436 catalytic residues [active] 312153000437 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 312153000438 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 312153000439 substrate binding site [chemical binding]; other site 312153000440 glutamase interaction surface [polypeptide binding]; other site 312153000441 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 312153000442 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 312153000443 metal binding site [ion binding]; metal-binding site 312153000444 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 312153000445 nucleotide binding site/active site [active] 312153000446 HIT family signature motif; other site 312153000447 catalytic residue [active] 312153000448 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 312153000449 sec-independent translocase; Provisional; Region: tatB; PRK01919 312153000450 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 312153000451 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 312153000452 eyelet of channel; other site 312153000453 trimer interface [polypeptide binding]; other site 312153000454 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 312153000455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000456 binding surface 312153000457 TPR motif; other site 312153000458 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 312153000459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000460 binding surface 312153000461 TPR motif; other site 312153000462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000463 binding surface 312153000464 TPR motif; other site 312153000465 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 312153000466 Tetratricopeptide repeat; Region: TPR_1; pfam00515 312153000467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000468 TPR motif; other site 312153000469 binding surface 312153000470 TPR repeat; Region: TPR_11; pfam13414 312153000471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000472 binding surface 312153000473 TPR motif; other site 312153000474 TPR repeat; Region: TPR_11; pfam13414 312153000475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153000476 binding surface 312153000477 TPR motif; other site 312153000478 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 312153000479 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 312153000480 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 312153000481 protein binding site [polypeptide binding]; other site 312153000482 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 312153000483 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 312153000484 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 312153000485 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 312153000486 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 312153000487 [2Fe-2S] cluster binding site [ion binding]; other site 312153000488 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 312153000489 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 312153000490 Qi binding site; other site 312153000491 intrachain domain interface; other site 312153000492 interchain domain interface [polypeptide binding]; other site 312153000493 heme bH binding site [chemical binding]; other site 312153000494 heme bL binding site [chemical binding]; other site 312153000495 Qo binding site; other site 312153000496 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 312153000497 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 312153000498 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 312153000499 stringent starvation protein A; Provisional; Region: sspA; PRK09481 312153000500 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 312153000501 C-terminal domain interface [polypeptide binding]; other site 312153000502 putative GSH binding site (G-site) [chemical binding]; other site 312153000503 dimer interface [polypeptide binding]; other site 312153000504 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 312153000505 dimer interface [polypeptide binding]; other site 312153000506 N-terminal domain interface [polypeptide binding]; other site 312153000507 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 312153000508 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 312153000509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153000510 metabolite-proton symporter; Region: 2A0106; TIGR00883 312153000511 putative substrate translocation pore; other site 312153000512 Phasin protein; Region: Phasin_2; pfam09361 312153000513 RmuC family; Region: RmuC; pfam02646 312153000514 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 312153000515 putative GSH binding site [chemical binding]; other site 312153000516 catalytic residues [active] 312153000517 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 312153000518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153000519 S-adenosylmethionine binding site [chemical binding]; other site 312153000520 peptide chain release factor 1; Validated; Region: prfA; PRK00591 312153000521 This domain is found in peptide chain release factors; Region: PCRF; smart00937 312153000522 RF-1 domain; Region: RF-1; pfam00472 312153000523 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 312153000524 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 312153000525 tRNA; other site 312153000526 putative tRNA binding site [nucleotide binding]; other site 312153000527 putative NADP binding site [chemical binding]; other site 312153000528 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 312153000529 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 312153000530 ligand binding site [chemical binding]; other site 312153000531 active site 312153000532 UGI interface [polypeptide binding]; other site 312153000533 catalytic site [active] 312153000534 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 312153000535 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 312153000536 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 312153000537 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 312153000538 dimerization domain [polypeptide binding]; other site 312153000539 dimer interface [polypeptide binding]; other site 312153000540 catalytic residues [active] 312153000541 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 312153000542 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 312153000543 GTP-binding protein YchF; Reviewed; Region: PRK09601 312153000544 YchF GTPase; Region: YchF; cd01900 312153000545 G1 box; other site 312153000546 GTP/Mg2+ binding site [chemical binding]; other site 312153000547 Switch I region; other site 312153000548 G2 box; other site 312153000549 Switch II region; other site 312153000550 G3 box; other site 312153000551 G4 box; other site 312153000552 G5 box; other site 312153000553 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 312153000554 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 312153000555 active site 312153000556 ribulose/triose binding site [chemical binding]; other site 312153000557 phosphate binding site [ion binding]; other site 312153000558 substrate (anthranilate) binding pocket [chemical binding]; other site 312153000559 product (indole) binding pocket [chemical binding]; other site 312153000560 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 312153000561 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 312153000562 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 312153000563 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 312153000564 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 312153000565 glutamine binding [chemical binding]; other site 312153000566 catalytic triad [active] 312153000567 anthranilate synthase component I; Provisional; Region: PRK13565 312153000568 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 312153000569 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 312153000570 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 312153000571 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 312153000572 substrate binding site [chemical binding]; other site 312153000573 hexamer interface [polypeptide binding]; other site 312153000574 metal binding site [ion binding]; metal-binding site 312153000575 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 312153000576 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 312153000577 MltA specific insert domain; Region: MltA; smart00925 312153000578 3D domain; Region: 3D; pfam06725 312153000579 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 312153000580 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 312153000581 metal binding site [ion binding]; metal-binding site 312153000582 putative dimer interface [polypeptide binding]; other site 312153000583 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 312153000584 AAA domain; Region: AAA_26; pfam13500 312153000585 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 312153000586 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 312153000587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 312153000588 catalytic residue [active] 312153000589 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 312153000590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 312153000591 inhibitor-cofactor binding pocket; inhibition site 312153000592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153000593 catalytic residue [active] 312153000594 biotin synthase; Region: bioB; TIGR00433 312153000595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153000596 FeS/SAM binding site; other site 312153000597 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 312153000598 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 312153000599 diiron binding motif [ion binding]; other site 312153000600 cell division protein MraZ; Reviewed; Region: PRK00326 312153000601 MraZ protein; Region: MraZ; pfam02381 312153000602 MraZ protein; Region: MraZ; pfam02381 312153000603 MraW methylase family; Region: Methyltransf_5; cl17771 312153000604 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 312153000605 Cell division protein FtsL; Region: FtsL; cl11433 312153000606 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 312153000607 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 312153000608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 312153000609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 312153000610 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 312153000611 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153000612 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153000613 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 312153000614 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 312153000615 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153000616 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153000617 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 312153000618 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 312153000619 Mg++ binding site [ion binding]; other site 312153000620 putative catalytic motif [active] 312153000621 putative substrate binding site [chemical binding]; other site 312153000622 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 312153000623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153000624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153000625 cell division protein FtsW; Region: ftsW; TIGR02614 312153000626 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 312153000627 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 312153000628 active site 312153000629 homodimer interface [polypeptide binding]; other site 312153000630 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 312153000631 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 312153000632 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153000633 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153000634 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 312153000635 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 312153000636 ATP-grasp domain; Region: ATP-grasp_4; cl17255 312153000637 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 312153000638 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 312153000639 Cell division protein FtsQ; Region: FtsQ; pfam03799 312153000640 cell division protein FtsA; Region: ftsA; TIGR01174 312153000641 Cell division protein FtsA; Region: FtsA; smart00842 312153000642 Cell division protein FtsA; Region: FtsA; pfam14450 312153000643 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 312153000644 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 312153000645 nucleotide binding site [chemical binding]; other site 312153000646 SulA interaction site; other site 312153000647 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 312153000648 catalytic triad [active] 312153000649 dimer interface [polypeptide binding]; other site 312153000650 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 312153000651 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 312153000652 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 312153000653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 312153000654 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 312153000655 SEC-C motif; Region: SEC-C; pfam02810 312153000656 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 312153000657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153000658 catalytic loop [active] 312153000659 iron binding site [ion binding]; other site 312153000660 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 312153000661 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 312153000662 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 312153000663 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 312153000664 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 312153000665 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 312153000666 heterotetramer interface [polypeptide binding]; other site 312153000667 active site pocket [active] 312153000668 cleavage site 312153000669 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 312153000670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153000671 Walker A motif; other site 312153000672 ATP binding site [chemical binding]; other site 312153000673 Walker B motif; other site 312153000674 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 312153000675 active site 312153000676 8-oxo-dGMP binding site [chemical binding]; other site 312153000677 nudix motif; other site 312153000678 metal binding site [ion binding]; metal-binding site 312153000679 hypothetical protein; Provisional; Region: PRK05287 312153000680 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 312153000681 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 312153000682 CoA-binding site [chemical binding]; other site 312153000683 ATP-binding [chemical binding]; other site 312153000684 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 312153000685 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 312153000686 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 312153000687 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 312153000688 Type II/IV secretion system protein; Region: T2SE; pfam00437 312153000689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 312153000690 Walker A motif; other site 312153000691 ATP binding site [chemical binding]; other site 312153000692 Walker B motif; other site 312153000693 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 312153000694 Domain of unknown function DUF21; Region: DUF21; pfam01595 312153000695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 312153000696 Transporter associated domain; Region: CorC_HlyC; smart01091 312153000697 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 312153000698 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 312153000699 DNA binding site [nucleotide binding] 312153000700 active site 312153000701 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 312153000702 substrate binding pocket [chemical binding]; other site 312153000703 substrate-Mg2+ binding site; other site 312153000704 aspartate-rich region 1; other site 312153000705 aspartate-rich region 2; other site 312153000706 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 312153000707 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 312153000708 Na binding site [ion binding]; other site 312153000709 putative glycosylation site [posttranslational modification]; other site 312153000710 putative glycosylation site [posttranslational modification]; other site 312153000711 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 312153000712 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 312153000713 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 312153000714 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 312153000715 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 312153000716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 312153000717 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 312153000718 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 312153000719 substrate binding pocket [chemical binding]; other site 312153000720 chain length determination region; other site 312153000721 substrate-Mg2+ binding site; other site 312153000722 catalytic residues [active] 312153000723 aspartate-rich region 1; other site 312153000724 active site lid residues [active] 312153000725 aspartate-rich region 2; other site 312153000726 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 312153000727 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 312153000728 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 312153000729 GTPase CgtA; Reviewed; Region: obgE; PRK12299 312153000730 GTP1/OBG; Region: GTP1_OBG; pfam01018 312153000731 Obg GTPase; Region: Obg; cd01898 312153000732 G1 box; other site 312153000733 GTP/Mg2+ binding site [chemical binding]; other site 312153000734 Switch I region; other site 312153000735 G2 box; other site 312153000736 G3 box; other site 312153000737 Switch II region; other site 312153000738 G4 box; other site 312153000739 G5 box; other site 312153000740 gamma-glutamyl kinase; Provisional; Region: PRK05429 312153000741 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 312153000742 nucleotide binding site [chemical binding]; other site 312153000743 homotetrameric interface [polypeptide binding]; other site 312153000744 putative phosphate binding site [ion binding]; other site 312153000745 putative allosteric binding site; other site 312153000746 CNP1-like family; Region: CNP1; pfam08750 312153000747 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 312153000748 putative active site [active] 312153000749 Ap4A binding site [chemical binding]; other site 312153000750 nudix motif; other site 312153000751 putative metal binding site [ion binding]; other site 312153000752 prolyl-tRNA synthetase; Provisional; Region: PRK09194 312153000753 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 312153000754 dimer interface [polypeptide binding]; other site 312153000755 motif 1; other site 312153000756 active site 312153000757 motif 2; other site 312153000758 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 312153000759 putative deacylase active site [active] 312153000760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 312153000761 active site 312153000762 motif 3; other site 312153000763 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 312153000764 anticodon binding site; other site 312153000765 signal recognition particle protein; Provisional; Region: PRK10867 312153000766 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 312153000767 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 312153000768 P loop; other site 312153000769 GTP binding site [chemical binding]; other site 312153000770 Signal peptide binding domain; Region: SRP_SPB; pfam02978 312153000771 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 312153000772 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 312153000773 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 312153000774 amidase catalytic site [active] 312153000775 Zn binding residues [ion binding]; other site 312153000776 substrate binding site [chemical binding]; other site 312153000777 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 312153000778 ATP cone domain; Region: ATP-cone; pfam03477 312153000779 Class I ribonucleotide reductase; Region: RNR_I; cd01679 312153000780 active site 312153000781 dimer interface [polypeptide binding]; other site 312153000782 catalytic residues [active] 312153000783 effector binding site; other site 312153000784 R2 peptide binding site; other site 312153000785 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 312153000786 dimer interface [polypeptide binding]; other site 312153000787 putative radical transfer pathway; other site 312153000788 diiron center [ion binding]; other site 312153000789 tyrosyl radical; other site 312153000790 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 312153000791 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 312153000792 substrate binding site [chemical binding]; other site 312153000793 ATP binding site [chemical binding]; other site 312153000794 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 312153000795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153000796 S-adenosylmethionine binding site [chemical binding]; other site 312153000797 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 312153000798 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 312153000799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 312153000800 ATP-grasp domain; Region: ATP-grasp_4; cl17255 312153000801 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 312153000802 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 312153000803 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 312153000804 carboxyltransferase (CT) interaction site; other site 312153000805 biotinylation site [posttranslational modification]; other site 312153000806 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 312153000807 Dehydroquinase class II; Region: DHquinase_II; pfam01220 312153000808 trimer interface [polypeptide binding]; other site 312153000809 active site 312153000810 dimer interface [polypeptide binding]; other site 312153000811 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 312153000812 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 312153000813 catalytic residues [active] 312153000814 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 312153000815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 312153000816 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153000817 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153000818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 312153000819 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 312153000820 NAD(P) binding site [chemical binding]; other site 312153000821 homotetramer interface [polypeptide binding]; other site 312153000822 homodimer interface [polypeptide binding]; other site 312153000823 active site 312153000824 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 312153000825 RNB domain; Region: RNB; pfam00773 312153000826 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 312153000827 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 312153000828 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 312153000829 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 312153000830 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 312153000831 shikimate binding site; other site 312153000832 NAD(P) binding site [chemical binding]; other site 312153000833 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 312153000834 Transglycosylase; Region: Transgly; cl17702 312153000835 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 312153000836 active site 312153000837 dimer interface [polypeptide binding]; other site 312153000838 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 312153000839 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 312153000840 Cl binding site [ion binding]; other site 312153000841 oligomer interface [polypeptide binding]; other site 312153000842 Competence-damaged protein; Region: CinA; pfam02464 312153000843 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 312153000844 tetramer interfaces [polypeptide binding]; other site 312153000845 binuclear metal-binding site [ion binding]; other site 312153000846 thiamine monophosphate kinase; Provisional; Region: PRK05731 312153000847 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 312153000848 ATP binding site [chemical binding]; other site 312153000849 dimerization interface [polypeptide binding]; other site 312153000850 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 312153000851 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 312153000852 Malic enzyme, N-terminal domain; Region: malic; pfam00390 312153000853 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 312153000854 putative NAD(P) binding site [chemical binding]; other site 312153000855 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 312153000856 Barstar (barnase inhibitor); Region: Barstar; pfam01337 312153000857 RNAase interaction site [polypeptide binding]; other site 312153000858 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 312153000859 RNA methyltransferase, RsmE family; Region: TIGR00046 312153000860 transketolase; Reviewed; Region: PRK12753 312153000861 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 312153000862 TPP-binding site [chemical binding]; other site 312153000863 dimer interface [polypeptide binding]; other site 312153000864 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 312153000865 PYR/PP interface [polypeptide binding]; other site 312153000866 dimer interface [polypeptide binding]; other site 312153000867 TPP binding site [chemical binding]; other site 312153000868 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 312153000869 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 312153000870 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 312153000871 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 312153000872 ferric uptake regulator; Provisional; Region: fur; PRK09462 312153000873 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 312153000874 metal binding site 2 [ion binding]; metal-binding site 312153000875 putative DNA binding helix; other site 312153000876 metal binding site 1 [ion binding]; metal-binding site 312153000877 dimer interface [polypeptide binding]; other site 312153000878 structural Zn2+ binding site [ion binding]; other site 312153000879 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 312153000880 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 312153000881 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 312153000882 dihydrodipicolinate reductase; Provisional; Region: PRK00048 312153000883 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 312153000884 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 312153000885 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 312153000886 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 312153000887 HIGH motif; other site 312153000888 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 312153000889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153000890 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153000891 active site 312153000892 KMSKS motif; other site 312153000893 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 312153000894 tRNA binding surface [nucleotide binding]; other site 312153000895 Lipopolysaccharide-assembly; Region: LptE; pfam04390 312153000896 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 312153000897 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 312153000898 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 312153000899 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 312153000900 putative catalytic cysteine [active] 312153000901 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 312153000902 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 312153000903 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 312153000904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153000905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153000906 Rubredoxin [Energy production and conversion]; Region: COG1773 312153000907 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 312153000908 iron binding site [ion binding]; other site 312153000909 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 312153000910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 312153000911 inhibitor-cofactor binding pocket; inhibition site 312153000912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153000913 catalytic residue [active] 312153000914 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 312153000915 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 312153000916 active site 312153000917 metal binding site [ion binding]; metal-binding site 312153000918 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 312153000919 DNA photolyase; Region: DNA_photolyase; pfam00875 312153000920 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 312153000921 Uncharacterized conserved protein [Function unknown]; Region: COG1434 312153000922 putative active site [active] 312153000923 hypothetical protein; Validated; Region: PRK00228 312153000924 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 312153000925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153000926 active site 312153000927 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 312153000928 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 312153000929 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 312153000930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153000931 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 312153000932 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 312153000933 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 312153000934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 312153000935 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 312153000936 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 312153000937 NAD binding site [chemical binding]; other site 312153000938 substrate binding site [chemical binding]; other site 312153000939 homodimer interface [polypeptide binding]; other site 312153000940 active site 312153000941 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 312153000942 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 312153000943 NADP binding site [chemical binding]; other site 312153000944 active site 312153000945 putative substrate binding site [chemical binding]; other site 312153000946 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 312153000947 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 312153000948 substrate binding site; other site 312153000949 tetramer interface; other site 312153000950 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 312153000951 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 312153000952 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153000953 putative active site [active] 312153000954 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 312153000955 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 312153000956 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 312153000957 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 312153000958 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 312153000959 NAD binding site [chemical binding]; other site 312153000960 putative substrate binding site 2 [chemical binding]; other site 312153000961 putative substrate binding site 1 [chemical binding]; other site 312153000962 active site 312153000963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153000964 S-adenosylmethionine binding site [chemical binding]; other site 312153000965 succinic semialdehyde dehydrogenase; Region: PLN02278 312153000966 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 312153000967 tetramerization interface [polypeptide binding]; other site 312153000968 NAD(P) binding site [chemical binding]; other site 312153000969 catalytic residues [active] 312153000970 transcription antitermination factor NusB; Region: nusB; TIGR01951 312153000971 putative RNA binding site [nucleotide binding]; other site 312153000972 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 312153000973 homopentamer interface [polypeptide binding]; other site 312153000974 active site 312153000975 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 312153000976 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 312153000977 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 312153000978 dimerization interface [polypeptide binding]; other site 312153000979 active site 312153000980 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 312153000981 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 312153000982 catalytic motif [active] 312153000983 Zn binding site [ion binding]; other site 312153000984 RibD C-terminal domain; Region: RibD_C; cl17279 312153000985 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 312153000986 Lumazine binding domain; Region: Lum_binding; pfam00677 312153000987 Lumazine binding domain; Region: Lum_binding; pfam00677 312153000988 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 312153000989 Ligand Binding Site [chemical binding]; other site 312153000990 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 312153000991 Tetratricopeptide repeat; Region: TPR_6; pfam13174 312153000992 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 312153000993 ligand binding site [chemical binding]; other site 312153000994 translocation protein TolB; Provisional; Region: tolB; PRK02889 312153000995 TolB amino-terminal domain; Region: TolB_N; pfam04052 312153000996 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 312153000997 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 312153000998 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 312153000999 TolA protein; Region: tolA_full; TIGR02794 312153001000 TonB C terminal; Region: TonB_2; pfam13103 312153001001 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 312153001002 TolR protein; Region: tolR; TIGR02801 312153001003 TolQ protein; Region: tolQ; TIGR02796 312153001004 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 312153001005 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 312153001006 dimer interface [polypeptide binding]; other site 312153001007 active site 312153001008 glycine-pyridoxal phosphate binding site [chemical binding]; other site 312153001009 folate binding site [chemical binding]; other site 312153001010 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 312153001011 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 312153001012 ATP cone domain; Region: ATP-cone; pfam03477 312153001013 adenylate kinase; Reviewed; Region: adk; PRK00279 312153001014 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 312153001015 AMP-binding site [chemical binding]; other site 312153001016 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 312153001017 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 312153001018 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 312153001019 Ligand binding site; other site 312153001020 oligomer interface; other site 312153001021 Uncharacterized conserved protein [Function unknown]; Region: COG2835 312153001022 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 312153001023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 312153001024 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 312153001025 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 312153001026 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 312153001027 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 312153001028 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 312153001029 generic binding surface II; other site 312153001030 generic binding surface I; other site 312153001031 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 312153001032 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 312153001033 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 312153001034 FAD binding domain; Region: FAD_binding_4; pfam01565 312153001035 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 312153001036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 312153001037 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 312153001038 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 312153001039 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 312153001040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 312153001041 active site 312153001042 DNA binding site [nucleotide binding] 312153001043 Int/Topo IB signature motif; other site 312153001044 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 312153001045 Predicted membrane protein [Function unknown]; Region: COG3686 312153001046 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 312153001047 active site 312153001048 High potential iron-sulfur protein; Region: HIPIP; pfam01355 312153001049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 312153001050 Helix-turn-helix domain; Region: HTH_28; pfam13518 312153001051 Helix-turn-helix domain; Region: HTH_28; pfam13518 312153001052 Homeodomain-like domain; Region: HTH_32; pfam13565 312153001053 putative transposase OrfB; Reviewed; Region: PHA02517 312153001054 HTH-like domain; Region: HTH_21; pfam13276 312153001055 Integrase core domain; Region: rve; pfam00665 312153001056 Integrase core domain; Region: rve_2; pfam13333 312153001057 HPP family; Region: HPP; pfam04982 312153001058 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 312153001059 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 312153001060 Substrate binding site; other site 312153001061 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 312153001062 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 312153001063 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 312153001064 NADP-binding site; other site 312153001065 homotetramer interface [polypeptide binding]; other site 312153001066 substrate binding site [chemical binding]; other site 312153001067 homodimer interface [polypeptide binding]; other site 312153001068 active site 312153001069 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 312153001070 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 312153001071 NADP binding site [chemical binding]; other site 312153001072 active site 312153001073 putative substrate binding site [chemical binding]; other site 312153001074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153001075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 312153001076 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 312153001077 metal-binding site 312153001078 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 312153001079 active site 312153001080 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 312153001081 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 312153001082 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 312153001083 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153001084 putative active site [active] 312153001085 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 312153001086 Bacterial sugar transferase; Region: Bac_transf; pfam02397 312153001087 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 312153001088 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 312153001089 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 312153001090 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 312153001091 inhibitor-cofactor binding pocket; inhibition site 312153001092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001093 catalytic residue [active] 312153001094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153001095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 312153001096 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 312153001097 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 312153001098 putative trimer interface [polypeptide binding]; other site 312153001099 putative CoA binding site [chemical binding]; other site 312153001100 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 312153001101 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 312153001102 Mg++ binding site [ion binding]; other site 312153001103 putative catalytic motif [active] 312153001104 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 312153001105 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 312153001106 Probable Catalytic site; other site 312153001107 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 312153001108 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 312153001109 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 312153001110 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 312153001111 Walker A/P-loop; other site 312153001112 ATP binding site [chemical binding]; other site 312153001113 Q-loop/lid; other site 312153001114 ABC transporter signature motif; other site 312153001115 Walker B; other site 312153001116 D-loop; other site 312153001117 H-loop/switch region; other site 312153001118 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 312153001119 putative carbohydrate binding site [chemical binding]; other site 312153001120 Methyltransferase domain; Region: Methyltransf_23; pfam13489 312153001121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001122 S-adenosylmethionine binding site [chemical binding]; other site 312153001123 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 312153001124 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 312153001125 putative ligand binding site [chemical binding]; other site 312153001126 putative catalytic site [active] 312153001127 Rhamnan synthesis protein F; Region: RgpF; pfam05045 312153001128 Methyltransferase domain; Region: Methyltransf_31; pfam13847 312153001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001130 S-adenosylmethionine binding site [chemical binding]; other site 312153001131 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 312153001132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 312153001133 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 312153001134 NAD(P) binding site [chemical binding]; other site 312153001135 active site 312153001136 hypothetical protein; Provisional; Region: PRK07233 312153001137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 312153001138 Predicted membrane protein [Function unknown]; Region: COG2246 312153001139 GtrA-like protein; Region: GtrA; pfam04138 312153001140 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 312153001141 classical (c) SDRs; Region: SDR_c; cd05233 312153001142 NAD(P) binding site [chemical binding]; other site 312153001143 active site 312153001144 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 312153001145 FAD binding domain; Region: FAD_binding_4; pfam01565 312153001146 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 312153001147 Divergent PAP2 family; Region: DUF212; pfam02681 312153001148 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 312153001149 ligand-binding site [chemical binding]; other site 312153001150 Methyltransferase domain; Region: Methyltransf_23; pfam13489 312153001151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001152 S-adenosylmethionine binding site [chemical binding]; other site 312153001153 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 312153001154 Ligand binding site; other site 312153001155 Putative Catalytic site; other site 312153001156 DXD motif; other site 312153001157 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 312153001158 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 312153001159 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 312153001160 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 312153001161 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 312153001162 putative active site [active] 312153001163 Predicted transcriptional regulator [Transcription]; Region: COG4190 312153001164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 312153001165 putative DNA binding site [nucleotide binding]; other site 312153001166 putative Zn2+ binding site [ion binding]; other site 312153001167 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 312153001168 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 312153001169 active site 312153001170 SAM binding site [chemical binding]; other site 312153001171 homodimer interface [polypeptide binding]; other site 312153001172 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153001173 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 312153001174 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 312153001175 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 312153001176 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 312153001177 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 312153001178 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 312153001179 RES domain; Region: RES; smart00953 312153001180 Fic/DOC family; Region: Fic; cl00960 312153001181 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 312153001182 Acyltransferase family; Region: Acyl_transf_3; pfam01757 312153001183 Protein of unknown function (DUF615); Region: DUF615; pfam04751 312153001184 choline dehydrogenase; Validated; Region: PRK02106 312153001185 lycopene cyclase; Region: lycopene_cycl; TIGR01789 312153001186 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 312153001187 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 312153001188 EamA-like transporter family; Region: EamA; pfam00892 312153001189 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 312153001190 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 312153001191 putative ligand binding site [chemical binding]; other site 312153001192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 312153001193 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 312153001194 TM-ABC transporter signature motif; other site 312153001195 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 312153001196 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 312153001197 TM-ABC transporter signature motif; other site 312153001198 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 312153001199 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 312153001200 Walker A/P-loop; other site 312153001201 ATP binding site [chemical binding]; other site 312153001202 Q-loop/lid; other site 312153001203 ABC transporter signature motif; other site 312153001204 Walker B; other site 312153001205 D-loop; other site 312153001206 H-loop/switch region; other site 312153001207 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 312153001208 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 312153001209 Walker A/P-loop; other site 312153001210 ATP binding site [chemical binding]; other site 312153001211 Q-loop/lid; other site 312153001212 ABC transporter signature motif; other site 312153001213 Walker B; other site 312153001214 D-loop; other site 312153001215 H-loop/switch region; other site 312153001216 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 312153001217 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 312153001218 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 312153001219 active site 312153001220 substrate binding site [chemical binding]; other site 312153001221 Mg2+ binding site [ion binding]; other site 312153001222 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 312153001223 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 312153001224 N-acetyl-D-glucosamine binding site [chemical binding]; other site 312153001225 catalytic residue [active] 312153001226 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 312153001227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 312153001228 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 312153001229 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 312153001230 Sensors of blue-light using FAD; Region: BLUF; pfam04940 312153001231 TMAO/DMSO reductase; Reviewed; Region: PRK05363 312153001232 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 312153001233 Moco binding site; other site 312153001234 metal coordination site [ion binding]; other site 312153001235 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 312153001236 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 312153001237 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 312153001238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 312153001239 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 312153001240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 312153001241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 312153001242 Isochorismatase family; Region: Isochorismatase; pfam00857 312153001243 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 312153001244 catalytic triad [active] 312153001245 conserved cis-peptide bond; other site 312153001246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 312153001247 malonic semialdehyde reductase; Provisional; Region: PRK10538 312153001248 NAD(P) binding site [chemical binding]; other site 312153001249 active site 312153001250 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 312153001251 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 312153001252 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 312153001253 RNA binding surface [nucleotide binding]; other site 312153001254 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 312153001255 active site 312153001256 uracil binding [chemical binding]; other site 312153001257 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 312153001258 aromatic arch; other site 312153001259 DCoH dimer interaction site [polypeptide binding]; other site 312153001260 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 312153001261 DCoH tetramer interaction site [polypeptide binding]; other site 312153001262 substrate binding site [chemical binding]; other site 312153001263 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 312153001264 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 312153001265 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 312153001266 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 312153001267 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 312153001268 folate binding site [chemical binding]; other site 312153001269 NADP+ binding site [chemical binding]; other site 312153001270 thymidylate synthase; Reviewed; Region: thyA; PRK01827 312153001271 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 312153001272 dimerization interface [polypeptide binding]; other site 312153001273 active site 312153001274 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 312153001275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153001276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153001277 Ferredoxin [Energy production and conversion]; Region: COG1146 312153001278 4Fe-4S binding domain; Region: Fer4; pfam00037 312153001279 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 312153001280 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 312153001281 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 312153001282 dimerization interface [polypeptide binding]; other site 312153001283 ligand binding site [chemical binding]; other site 312153001284 NADP binding site [chemical binding]; other site 312153001285 catalytic site [active] 312153001286 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 312153001287 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 312153001288 dimer interface [polypeptide binding]; other site 312153001289 putative functional site; other site 312153001290 putative MPT binding site; other site 312153001291 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 312153001292 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 312153001293 GTP binding site; other site 312153001294 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 312153001295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153001296 FeS/SAM binding site; other site 312153001297 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 312153001298 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 312153001299 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 312153001300 homodimer interface [polypeptide binding]; other site 312153001301 oligonucleotide binding site [chemical binding]; other site 312153001302 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 312153001303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153001304 RNA binding surface [nucleotide binding]; other site 312153001305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 312153001306 active site 312153001307 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 312153001308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 312153001309 motif II; other site 312153001310 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 312153001311 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 312153001312 tandem repeat interface [polypeptide binding]; other site 312153001313 oligomer interface [polypeptide binding]; other site 312153001314 active site residues [active] 312153001315 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 312153001316 putative SAM binding site [chemical binding]; other site 312153001317 homodimer interface [polypeptide binding]; other site 312153001318 Maf-like protein; Region: Maf; pfam02545 312153001319 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 312153001320 active site 312153001321 dimer interface [polypeptide binding]; other site 312153001322 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 312153001323 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 312153001324 putative phosphate acyltransferase; Provisional; Region: PRK05331 312153001325 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 312153001326 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 312153001327 dimer interface [polypeptide binding]; other site 312153001328 active site 312153001329 CoA binding pocket [chemical binding]; other site 312153001330 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 312153001331 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 312153001332 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 312153001333 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 312153001334 NAD(P) binding site [chemical binding]; other site 312153001335 homotetramer interface [polypeptide binding]; other site 312153001336 homodimer interface [polypeptide binding]; other site 312153001337 active site 312153001338 acyl carrier protein; Provisional; Region: acpP; PRK00982 312153001339 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 312153001340 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 312153001341 dimer interface [polypeptide binding]; other site 312153001342 active site 312153001343 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 312153001344 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 312153001345 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 312153001346 protein binding site [polypeptide binding]; other site 312153001347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 312153001348 protein binding site [polypeptide binding]; other site 312153001349 GTP-binding protein LepA; Provisional; Region: PRK05433 312153001350 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 312153001351 G1 box; other site 312153001352 putative GEF interaction site [polypeptide binding]; other site 312153001353 GTP/Mg2+ binding site [chemical binding]; other site 312153001354 Switch I region; other site 312153001355 G2 box; other site 312153001356 G3 box; other site 312153001357 Switch II region; other site 312153001358 G4 box; other site 312153001359 G5 box; other site 312153001360 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 312153001361 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 312153001362 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 312153001363 signal peptidase I; Provisional; Region: PRK10861 312153001364 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 312153001365 Catalytic site [active] 312153001366 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 312153001367 ribonuclease III; Reviewed; Region: rnc; PRK00102 312153001368 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 312153001369 dimerization interface [polypeptide binding]; other site 312153001370 active site 312153001371 metal binding site [ion binding]; metal-binding site 312153001372 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 312153001373 dsRNA binding site [nucleotide binding]; other site 312153001374 GTPase Era; Reviewed; Region: era; PRK00089 312153001375 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 312153001376 G1 box; other site 312153001377 GTP/Mg2+ binding site [chemical binding]; other site 312153001378 Switch I region; other site 312153001379 G2 box; other site 312153001380 Switch II region; other site 312153001381 G3 box; other site 312153001382 G5 box; other site 312153001383 KH domain; Region: KH_2; pfam07650 312153001384 Recombination protein O N terminal; Region: RecO_N; pfam11967 312153001385 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 312153001386 Recombination protein O C terminal; Region: RecO_C; pfam02565 312153001387 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 312153001388 active site 312153001389 hydrophilic channel; other site 312153001390 dimerization interface [polypeptide binding]; other site 312153001391 catalytic residues [active] 312153001392 active site lid [active] 312153001393 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 312153001394 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 312153001395 beta-hexosaminidase; Provisional; Region: PRK05337 312153001396 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 312153001397 active site 312153001398 zinc binding site [ion binding]; other site 312153001399 elongation factor P; Validated; Region: PRK00529 312153001400 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 312153001401 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 312153001402 RNA binding site [nucleotide binding]; other site 312153001403 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 312153001404 RNA binding site [nucleotide binding]; other site 312153001405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 312153001406 conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837 312153001407 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 312153001408 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 312153001409 GIY-YIG motif/motif A; other site 312153001410 active site 312153001411 catalytic site [active] 312153001412 putative DNA binding site [nucleotide binding]; other site 312153001413 metal binding site [ion binding]; metal-binding site 312153001414 UvrB/uvrC motif; Region: UVR; pfam02151 312153001415 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 312153001416 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 312153001417 LexA repressor; Validated; Region: PRK00215 312153001418 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 312153001419 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 312153001420 Catalytic site [active] 312153001421 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 312153001422 active site 312153001423 homotetramer interface [polypeptide binding]; other site 312153001424 homodimer interface [polypeptide binding]; other site 312153001425 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 312153001426 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 312153001427 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 312153001428 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 312153001429 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 312153001430 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 312153001431 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 312153001432 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 312153001433 Walker A motif; other site 312153001434 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 312153001435 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 312153001436 Homing endonuclease; Region: Hom_end; pfam05204 312153001437 replicative DNA helicase; Region: DnaB; TIGR00665 312153001438 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 312153001439 ATP binding site [chemical binding]; other site 312153001440 Walker B motif; other site 312153001441 DNA binding loops [nucleotide binding] 312153001442 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 312153001443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 312153001444 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 312153001445 NlpC/P60 family; Region: NLPC_P60; pfam00877 312153001446 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 312153001447 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 312153001448 putative active site [active] 312153001449 PhoH-like protein; Region: PhoH; pfam02562 312153001450 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 312153001451 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 312153001452 catalytic triad [active] 312153001453 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 312153001454 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 312153001455 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 312153001456 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 312153001457 NAD binding site [chemical binding]; other site 312153001458 substrate binding site [chemical binding]; other site 312153001459 active site 312153001460 putative formyltransferase; Provisional; Region: PRK06988 312153001461 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 312153001462 active site 312153001463 substrate binding site [chemical binding]; other site 312153001464 cosubstrate binding site; other site 312153001465 catalytic site [active] 312153001466 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 312153001467 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 312153001468 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 312153001469 Ligand binding site; other site 312153001470 Putative Catalytic site; other site 312153001471 DXD motif; other site 312153001472 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 312153001473 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 312153001474 inhibitor-cofactor binding pocket; inhibition site 312153001475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001476 catalytic residue [active] 312153001477 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 312153001478 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 312153001479 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 312153001480 aminotransferase AlaT; Validated; Region: PRK09265 312153001481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153001482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001483 homodimer interface [polypeptide binding]; other site 312153001484 catalytic residue [active] 312153001485 homoserine dehydrogenase; Provisional; Region: PRK06349 312153001486 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 312153001487 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 312153001488 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 312153001489 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 312153001490 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 312153001491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001492 catalytic residue [active] 312153001493 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 312153001494 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 312153001495 dimer interface [polypeptide binding]; other site 312153001496 putative functional site; other site 312153001497 putative MPT binding site; other site 312153001498 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 312153001499 MoaE interaction surface [polypeptide binding]; other site 312153001500 MoeB interaction surface [polypeptide binding]; other site 312153001501 thiocarboxylated glycine; other site 312153001502 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 312153001503 MoaE homodimer interface [polypeptide binding]; other site 312153001504 MoaD interaction [polypeptide binding]; other site 312153001505 active site residues [active] 312153001506 Carboxylesterase family; Region: COesterase; pfam00135 312153001507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 312153001508 substrate binding pocket [chemical binding]; other site 312153001509 catalytic triad [active] 312153001510 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 312153001511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153001512 putative substrate translocation pore; other site 312153001513 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 312153001514 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 312153001515 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 312153001516 GIY-YIG motif/motif A; other site 312153001517 putative active site [active] 312153001518 putative metal binding site [ion binding]; other site 312153001519 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 312153001520 Clp amino terminal domain; Region: Clp_N; pfam02861 312153001521 Clp amino terminal domain; Region: Clp_N; pfam02861 312153001522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153001523 Walker A motif; other site 312153001524 ATP binding site [chemical binding]; other site 312153001525 Walker B motif; other site 312153001526 arginine finger; other site 312153001527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153001528 Walker A motif; other site 312153001529 ATP binding site [chemical binding]; other site 312153001530 Walker B motif; other site 312153001531 arginine finger; other site 312153001532 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 312153001533 Biofilm formation and stress response factor; Region: BsmA; pfam10014 312153001534 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153001536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153001537 putative substrate translocation pore; other site 312153001538 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 312153001539 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 312153001540 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 312153001541 metal-binding site [ion binding] 312153001542 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 312153001543 Soluble P-type ATPase [General function prediction only]; Region: COG4087 312153001544 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 312153001545 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 312153001546 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 312153001547 Low-spin heme binding site [chemical binding]; other site 312153001548 Putative water exit pathway; other site 312153001549 Binuclear center (active site) [active] 312153001550 Putative proton exit pathway; other site 312153001551 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 312153001552 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 312153001553 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 312153001554 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 312153001555 Cytochrome c; Region: Cytochrom_C; pfam00034 312153001556 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 312153001557 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 312153001558 4Fe-4S binding domain; Region: Fer4_5; pfam12801 312153001559 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 312153001560 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 312153001561 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 312153001562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 312153001563 ligand binding site [chemical binding]; other site 312153001564 flexible hinge region; other site 312153001565 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 312153001566 putative switch regulator; other site 312153001567 non-specific DNA interactions [nucleotide binding]; other site 312153001568 DNA binding site [nucleotide binding] 312153001569 sequence specific DNA binding site [nucleotide binding]; other site 312153001570 putative cAMP binding site [chemical binding]; other site 312153001571 Family description; Region: DsbD_2; pfam13386 312153001572 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 312153001573 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 312153001574 Ligand Binding Site [chemical binding]; other site 312153001575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 312153001576 Peptidase family M23; Region: Peptidase_M23; pfam01551 312153001577 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 312153001578 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 312153001579 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 312153001580 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 312153001581 active site pocket [active] 312153001582 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 312153001583 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 312153001584 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 312153001585 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 312153001586 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 312153001587 inhibitor site; inhibition site 312153001588 active site 312153001589 dimer interface [polypeptide binding]; other site 312153001590 catalytic residue [active] 312153001591 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 312153001592 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 312153001593 putative ligand binding site [chemical binding]; other site 312153001594 NAD binding site [chemical binding]; other site 312153001595 catalytic site [active] 312153001596 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 312153001597 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 312153001598 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 312153001599 enterobactin exporter EntS; Provisional; Region: PRK10489 312153001600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153001601 putative substrate translocation pore; other site 312153001602 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 312153001603 Cytochrome C' Region: Cytochrom_C_2; pfam01322 312153001604 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 312153001605 Peptidase family M50; Region: Peptidase_M50; pfam02163 312153001606 active site 312153001607 putative substrate binding region [chemical binding]; other site 312153001608 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 312153001609 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 312153001610 putative active site [active] 312153001611 metal binding site [ion binding]; metal-binding site 312153001612 chromosome condensation membrane protein; Provisional; Region: PRK14196 312153001613 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153001614 Chromate transporter; Region: Chromate_transp; pfam02417 312153001615 Chromate transporter; Region: Chromate_transp; pfam02417 312153001616 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 312153001617 dimerization interface [polypeptide binding]; other site 312153001618 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 312153001619 NAD binding site [chemical binding]; other site 312153001620 ligand binding site [chemical binding]; other site 312153001621 catalytic site [active] 312153001622 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 312153001623 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153001624 rhodanese superfamily protein; Provisional; Region: PRK05320 312153001625 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153001626 active site residue [active] 312153001627 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153001628 Uncharacterized conserved protein [Function unknown]; Region: COG2128 312153001629 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 312153001630 Pirin-related protein [General function prediction only]; Region: COG1741 312153001631 Pirin; Region: Pirin; pfam02678 312153001632 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 312153001633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 312153001634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001635 S-adenosylmethionine binding site [chemical binding]; other site 312153001636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153001637 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 312153001638 TPR motif; other site 312153001639 binding surface 312153001640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153001641 binding surface 312153001642 TPR motif; other site 312153001643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153001644 phosphoglycolate phosphatase; Provisional; Region: PRK13222 312153001645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 312153001646 motif II; other site 312153001647 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 312153001648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001649 S-adenosylmethionine binding site [chemical binding]; other site 312153001650 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 312153001651 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 312153001652 ligand binding site [chemical binding]; other site 312153001653 DNA gyrase subunit A; Validated; Region: PRK05560 312153001654 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 312153001655 CAP-like domain; other site 312153001656 active site 312153001657 primary dimer interface [polypeptide binding]; other site 312153001658 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001659 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153001664 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 312153001665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 312153001666 catalytic residue [active] 312153001667 Chorismate mutase type II; Region: CM_2; cl00693 312153001668 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 312153001669 Prephenate dehydratase; Region: PDT; pfam00800 312153001670 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 312153001671 putative L-Phe binding site [chemical binding]; other site 312153001672 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 312153001673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153001674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001675 homodimer interface [polypeptide binding]; other site 312153001676 catalytic residue [active] 312153001677 prephenate dehydrogenase; Validated; Region: PRK08507 312153001678 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 312153001679 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 312153001680 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 312153001681 hinge; other site 312153001682 active site 312153001683 cytidylate kinase; Provisional; Region: cmk; PRK00023 312153001684 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 312153001685 CMP-binding site; other site 312153001686 The sites determining sugar specificity; other site 312153001687 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 312153001688 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 312153001689 RNA binding site [nucleotide binding]; other site 312153001690 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 312153001691 RNA binding site [nucleotide binding]; other site 312153001692 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 312153001693 RNA binding site [nucleotide binding]; other site 312153001694 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 312153001695 RNA binding site [nucleotide binding]; other site 312153001696 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 312153001697 RNA binding site [nucleotide binding]; other site 312153001698 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 312153001699 RNA binding site [nucleotide binding]; other site 312153001700 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 312153001701 IHF dimer interface [polypeptide binding]; other site 312153001702 IHF - DNA interface [nucleotide binding]; other site 312153001703 tetratricopeptide repeat protein; Provisional; Region: PRK11788 312153001704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153001705 TPR motif; other site 312153001706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153001707 binding surface 312153001708 TPR motif; other site 312153001709 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 312153001710 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 312153001711 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 312153001712 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 312153001713 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 312153001714 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 312153001715 putative ribose interaction site [chemical binding]; other site 312153001716 putative ADP binding site [chemical binding]; other site 312153001717 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 312153001718 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 312153001719 NADP binding site [chemical binding]; other site 312153001720 homopentamer interface [polypeptide binding]; other site 312153001721 substrate binding site [chemical binding]; other site 312153001722 active site 312153001723 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 312153001724 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 312153001725 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 312153001726 cysteine synthase B; Region: cysM; TIGR01138 312153001727 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 312153001728 dimer interface [polypeptide binding]; other site 312153001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001730 catalytic residue [active] 312153001731 Transglycosylase SLT domain; Region: SLT_2; pfam13406 312153001732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 312153001733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 312153001734 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 312153001735 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 312153001736 putative active site [active] 312153001737 Zn binding site [ion binding]; other site 312153001738 acyl-CoA synthetase; Validated; Region: PRK08162 312153001739 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 312153001740 acyl-activating enzyme (AAE) consensus motif; other site 312153001741 putative active site [active] 312153001742 AMP binding site [chemical binding]; other site 312153001743 putative CoA binding site [chemical binding]; other site 312153001744 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 312153001745 Ligand binding site [chemical binding]; other site 312153001746 Electron transfer flavoprotein domain; Region: ETF; pfam01012 312153001747 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 312153001748 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 312153001749 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 312153001750 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 312153001751 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 312153001752 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 312153001753 active site 312153001754 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 312153001755 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 312153001756 META domain; Region: META; pfam03724 312153001757 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 312153001758 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 312153001759 RimM N-terminal domain; Region: RimM; pfam01782 312153001760 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 312153001761 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 312153001762 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 312153001763 putative active site [active] 312153001764 putative CoA binding site [chemical binding]; other site 312153001765 nudix motif; other site 312153001766 metal binding site [ion binding]; metal-binding site 312153001767 CobD/Cbib protein; Region: CobD_Cbib; cl00561 312153001768 GTPase RsgA; Reviewed; Region: PRK00098 312153001769 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 312153001770 RNA binding site [nucleotide binding]; other site 312153001771 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 312153001772 GTPase/Zn-binding domain interface [polypeptide binding]; other site 312153001773 GTP/Mg2+ binding site [chemical binding]; other site 312153001774 G4 box; other site 312153001775 G5 box; other site 312153001776 G1 box; other site 312153001777 Switch I region; other site 312153001778 G2 box; other site 312153001779 G3 box; other site 312153001780 Switch II region; other site 312153001781 Peptidase family M48; Region: Peptidase_M48; pfam01435 312153001782 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 312153001783 catalytic site [active] 312153001784 putative active site [active] 312153001785 putative substrate binding site [chemical binding]; other site 312153001786 dimer interface [polypeptide binding]; other site 312153001787 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 312153001788 MPT binding site; other site 312153001789 trimer interface [polypeptide binding]; other site 312153001790 peptidase PmbA; Provisional; Region: PRK11040 312153001791 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 312153001792 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 312153001793 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 312153001794 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 312153001795 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153001796 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 312153001797 putative hydrolase; Provisional; Region: PRK11460 312153001798 Protein of unknown function, DUF485; Region: DUF485; pfam04341 312153001799 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 312153001800 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 312153001801 Na binding site [ion binding]; other site 312153001802 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 312153001803 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 312153001804 active site 312153001805 catalytic site [active] 312153001806 substrate binding site [chemical binding]; other site 312153001807 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 312153001808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 312153001809 ligand binding site [chemical binding]; other site 312153001810 flexible hinge region; other site 312153001811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 312153001812 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 312153001813 metal binding triad; other site 312153001814 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 312153001815 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 312153001816 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 312153001817 CoA binding domain; Region: CoA_binding; cl17356 312153001818 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 312153001819 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 312153001820 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 312153001821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 312153001822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153001823 Coenzyme A binding pocket [chemical binding]; other site 312153001824 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 312153001825 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 312153001826 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 312153001827 putative N-terminal domain interface [polypeptide binding]; other site 312153001828 putative dimer interface [polypeptide binding]; other site 312153001829 putative substrate binding pocket (H-site) [chemical binding]; other site 312153001830 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 312153001831 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 312153001832 Cytochrome c553 [Energy production and conversion]; Region: COG2863 312153001833 Cytochrome c; Region: Cytochrom_C; pfam00034 312153001834 Phytochelatin synthase; Region: Phytochelatin; pfam05023 312153001835 Secretory lipase; Region: LIP; pfam03583 312153001836 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 312153001837 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 312153001838 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 312153001839 Cl- selectivity filter; other site 312153001840 Cl- binding residues [ion binding]; other site 312153001841 pore gating glutamate residue; other site 312153001842 dimer interface [polypeptide binding]; other site 312153001843 H+/Cl- coupling transport residue; other site 312153001844 pyruvate dehydrogenase; Provisional; Region: PRK09124 312153001845 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 312153001846 PYR/PP interface [polypeptide binding]; other site 312153001847 dimer interface [polypeptide binding]; other site 312153001848 tetramer interface [polypeptide binding]; other site 312153001849 TPP binding site [chemical binding]; other site 312153001850 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 312153001851 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 312153001852 TPP-binding site [chemical binding]; other site 312153001853 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153001854 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153001855 Cytochrome c; Region: Cytochrom_C; pfam00034 312153001856 Predicted membrane protein [Function unknown]; Region: COG2259 312153001857 Predicted membrane protein [Function unknown]; Region: COG4280 312153001858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153001859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 312153001860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153001861 dimer interface [polypeptide binding]; other site 312153001862 phosphorylation site [posttranslational modification] 312153001863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153001864 ATP binding site [chemical binding]; other site 312153001865 Mg2+ binding site [ion binding]; other site 312153001866 G-X-G motif; other site 312153001867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 312153001868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153001869 active site 312153001870 phosphorylation site [posttranslational modification] 312153001871 intermolecular recognition site; other site 312153001872 dimerization interface [polypeptide binding]; other site 312153001873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 312153001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153001875 active site 312153001876 phosphorylation site [posttranslational modification] 312153001877 intermolecular recognition site; other site 312153001878 dimerization interface [polypeptide binding]; other site 312153001879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 312153001880 DNA binding residues [nucleotide binding] 312153001881 dimerization interface [polypeptide binding]; other site 312153001882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 312153001883 dimerization interface [polypeptide binding]; other site 312153001884 putative DNA binding site [nucleotide binding]; other site 312153001885 putative Zn2+ binding site [ion binding]; other site 312153001886 hypothetical protein; Provisional; Region: PRK09272 312153001887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 312153001888 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 312153001889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153001890 Coenzyme A binding pocket [chemical binding]; other site 312153001891 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 312153001892 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 312153001893 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 312153001894 Methyltransferase domain; Region: Methyltransf_23; pfam13489 312153001895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153001896 S-adenosylmethionine binding site [chemical binding]; other site 312153001897 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 312153001898 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153001899 active site 312153001900 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 312153001901 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 312153001902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 312153001903 active site 312153001904 LTXXQ motif family protein; Region: LTXXQ; pfam07813 312153001905 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 312153001906 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 312153001907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 312153001908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 312153001909 DNA binding residues [nucleotide binding] 312153001910 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 312153001911 DNA-binding site [nucleotide binding]; DNA binding site 312153001912 RNA-binding motif; other site 312153001913 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 312153001914 rRNA binding site [nucleotide binding]; other site 312153001915 predicted 30S ribosome binding site; other site 312153001916 AAA domain; Region: AAA_33; pfam13671 312153001917 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 312153001918 active site 312153001919 glyoxylate reductase; Reviewed; Region: PRK13243 312153001920 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 312153001921 dimerization interface [polypeptide binding]; other site 312153001922 ligand binding site [chemical binding]; other site 312153001923 NADP binding site [chemical binding]; other site 312153001924 catalytic site [active] 312153001925 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 312153001926 tartronate semialdehyde reductase; Provisional; Region: PRK15059 312153001927 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 312153001928 AMIN domain; Region: AMIN; pfam11741 312153001929 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 312153001930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 312153001931 active site 312153001932 metal binding site [ion binding]; metal-binding site 312153001933 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 312153001934 epoxyqueuosine reductase; Region: TIGR00276 312153001935 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 312153001936 AzlC protein; Region: AzlC; pfam03591 312153001937 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 312153001938 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 312153001939 FAD binding domain; Region: FAD_binding_4; pfam01565 312153001940 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 312153001941 Transcriptional regulators [Transcription]; Region: GntR; COG1802 312153001942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 312153001943 DNA-binding site [nucleotide binding]; DNA binding site 312153001944 FCD domain; Region: FCD; pfam07729 312153001945 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 312153001946 homodimer interface [polypeptide binding]; other site 312153001947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153001948 catalytic residue [active] 312153001949 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 312153001950 helicase 45; Provisional; Region: PTZ00424 312153001951 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 312153001952 ATP binding site [chemical binding]; other site 312153001953 Mg++ binding site [ion binding]; other site 312153001954 motif III; other site 312153001955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153001956 nucleotide binding region [chemical binding]; other site 312153001957 ATP-binding site [chemical binding]; other site 312153001958 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 312153001959 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 312153001960 active site 312153001961 HIGH motif; other site 312153001962 nucleotide binding site [chemical binding]; other site 312153001963 active site 312153001964 KMSKS motif; other site 312153001965 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 312153001966 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 312153001967 putative active site [active] 312153001968 putative PHP Thumb interface [polypeptide binding]; other site 312153001969 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 312153001970 generic binding surface II; other site 312153001971 generic binding surface I; other site 312153001972 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 312153001973 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153001974 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153001975 putative active site [active] 312153001976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 312153001977 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 312153001978 Substrate binding site; other site 312153001979 metal-binding site 312153001980 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 312153001981 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 312153001982 putative metal binding site; other site 312153001983 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 312153001984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 312153001985 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 312153001986 Walker A/P-loop; other site 312153001987 ATP binding site [chemical binding]; other site 312153001988 Q-loop/lid; other site 312153001989 ABC transporter signature motif; other site 312153001990 Walker B; other site 312153001991 D-loop; other site 312153001992 H-loop/switch region; other site 312153001993 ribonuclease G; Provisional; Region: PRK11712 312153001994 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 312153001995 homodimer interface [polypeptide binding]; other site 312153001996 oligonucleotide binding site [chemical binding]; other site 312153001997 Maf-like protein; Region: Maf; pfam02545 312153001998 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 312153001999 active site 312153002000 dimer interface [polypeptide binding]; other site 312153002001 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 312153002002 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 312153002003 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 312153002004 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 312153002005 active site 312153002006 (T/H)XGH motif; other site 312153002007 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 312153002008 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 312153002009 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 312153002010 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 312153002011 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 312153002012 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 312153002013 hypothetical protein; Validated; Region: PRK00110 312153002014 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 312153002015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153002016 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 312153002017 substrate binding site [chemical binding]; other site 312153002018 dimerization interface [polypeptide binding]; other site 312153002019 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 312153002020 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 312153002021 Predicted permeases [General function prediction only]; Region: COG0795 312153002022 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 312153002023 multifunctional aminopeptidase A; Provisional; Region: PRK00913 312153002024 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 312153002025 interface (dimer of trimers) [polypeptide binding]; other site 312153002026 Substrate-binding/catalytic site; other site 312153002027 Zn-binding sites [ion binding]; other site 312153002028 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 312153002029 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 312153002030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 312153002031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153002032 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 312153002033 putative dimerization interface [polypeptide binding]; other site 312153002034 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 312153002035 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 312153002036 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 312153002037 DctM-like transporters; Region: DctM; pfam06808 312153002038 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 312153002039 malonyl-CoA synthase; Validated; Region: PRK07514 312153002040 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 312153002041 acyl-activating enzyme (AAE) consensus motif; other site 312153002042 active site 312153002043 AMP binding site [chemical binding]; other site 312153002044 CoA binding site [chemical binding]; other site 312153002045 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153002046 Cell division protein ZapA; Region: ZapA; pfam05164 312153002047 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 312153002048 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 312153002049 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 312153002050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 312153002051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 312153002052 ligand binding site [chemical binding]; other site 312153002053 flexible hinge region; other site 312153002054 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 312153002055 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 312153002056 PYR/PP interface [polypeptide binding]; other site 312153002057 dimer interface [polypeptide binding]; other site 312153002058 TPP binding site [chemical binding]; other site 312153002059 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 312153002060 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 312153002061 TPP-binding site; other site 312153002062 dimer interface [polypeptide binding]; other site 312153002063 formyl-coenzyme A transferase; Provisional; Region: PRK05398 312153002064 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153002065 PAS domain S-box; Region: sensory_box; TIGR00229 312153002066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 312153002067 putative active site [active] 312153002068 heme pocket [chemical binding]; other site 312153002069 formyl-coenzyme A transferase; Provisional; Region: PRK05398 312153002070 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153002071 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 312153002072 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 312153002073 putative active site [active] 312153002074 substrate binding site [chemical binding]; other site 312153002075 putative cosubstrate binding site; other site 312153002076 catalytic site [active] 312153002077 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 312153002078 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 312153002079 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153002080 active site 312153002081 pantoate--beta-alanine ligase; Region: panC; TIGR00018 312153002082 Pantoate-beta-alanine ligase; Region: PanC; cd00560 312153002083 active site 312153002084 ATP-binding site [chemical binding]; other site 312153002085 pantoate-binding site; other site 312153002086 HXXH motif; other site 312153002087 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 312153002088 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 312153002089 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 312153002090 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 312153002091 active site 312153002092 HIGH motif; other site 312153002093 KMSKS motif; other site 312153002094 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 312153002095 tRNA binding surface [nucleotide binding]; other site 312153002096 anticodon binding site; other site 312153002097 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 312153002098 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 312153002099 trimer interface [polypeptide binding]; other site 312153002100 active site 312153002101 Inward rectifier potassium channel; Region: IRK; pfam01007 312153002102 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 312153002103 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 312153002104 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 312153002105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 312153002106 catalytic residue [active] 312153002107 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 312153002108 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 312153002109 tetramerization interface [polypeptide binding]; other site 312153002110 active site 312153002111 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 312153002112 DctM-like transporters; Region: DctM; pfam06808 312153002113 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 312153002114 argininosuccinate lyase; Provisional; Region: PRK00855 312153002115 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 312153002116 active sites [active] 312153002117 tetramer interface [polypeptide binding]; other site 312153002118 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 312153002119 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 312153002120 domain interfaces; other site 312153002121 active site 312153002122 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 312153002123 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 312153002124 active site 312153002125 Chorismate lyase; Region: Chor_lyase; cl01230 312153002126 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 312153002127 DEAD-like helicases superfamily; Region: DEXDc; smart00487 312153002128 ATP binding site [chemical binding]; other site 312153002129 Mg++ binding site [ion binding]; other site 312153002130 motif III; other site 312153002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153002132 nucleotide binding region [chemical binding]; other site 312153002133 ATP-binding site [chemical binding]; other site 312153002134 LysE type translocator; Region: LysE; cl00565 312153002135 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 312153002136 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 312153002137 NAD(P) binding site [chemical binding]; other site 312153002138 catalytic residues [active] 312153002139 methionine sulfoxide reductase A; Provisional; Region: PRK14054 312153002140 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 312153002141 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 312153002142 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 312153002143 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 312153002144 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 312153002145 putative ATP binding site [chemical binding]; other site 312153002146 putative substrate interface [chemical binding]; other site 312153002147 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 312153002148 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 312153002149 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 312153002150 hexamer interface [polypeptide binding]; other site 312153002151 ligand binding site [chemical binding]; other site 312153002152 putative active site [active] 312153002153 NAD(P) binding site [chemical binding]; other site 312153002154 Predicted membrane protein [Function unknown]; Region: COG2119 312153002155 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 312153002156 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 312153002157 aminopeptidase N; Provisional; Region: pepN; PRK14015 312153002158 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 312153002159 active site 312153002160 Zn binding site [ion binding]; other site 312153002161 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 312153002162 AMP binding site [chemical binding]; other site 312153002163 metal binding site [ion binding]; metal-binding site 312153002164 active site 312153002165 cyanophycin synthetase; Provisional; Region: PRK14016 312153002166 ATP-grasp domain; Region: ATP-grasp_4; cl17255 312153002167 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153002168 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153002169 cyanophycin synthetase; Provisional; Region: PRK14016 312153002170 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 312153002171 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 312153002172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 312153002173 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 312153002174 Walker A/P-loop; other site 312153002175 ATP binding site [chemical binding]; other site 312153002176 Q-loop/lid; other site 312153002177 ABC transporter signature motif; other site 312153002178 Walker B; other site 312153002179 D-loop; other site 312153002180 H-loop/switch region; other site 312153002181 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 312153002182 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 312153002183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153002184 putative substrate translocation pore; other site 312153002185 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 312153002186 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 312153002187 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 312153002188 N-terminal plug; other site 312153002189 ligand-binding site [chemical binding]; other site 312153002190 BNR repeat-like domain; Region: BNR_2; pfam13088 312153002191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 312153002192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 312153002193 catalytic residues [active] 312153002194 Protein of unknown function (DUF461); Region: DUF461; pfam04314 312153002195 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 312153002196 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 312153002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153002198 active site 312153002199 phosphorylation site [posttranslational modification] 312153002200 intermolecular recognition site; other site 312153002201 dimerization interface [polypeptide binding]; other site 312153002202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 312153002203 DNA binding residues [nucleotide binding] 312153002204 dimerization interface [polypeptide binding]; other site 312153002205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 312153002206 non-specific DNA binding site [nucleotide binding]; other site 312153002207 salt bridge; other site 312153002208 sequence-specific DNA binding site [nucleotide binding]; other site 312153002209 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 312153002210 Nitrogen regulatory protein P-II; Region: P-II; smart00938 312153002211 NAD synthetase; Provisional; Region: PRK13981 312153002212 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 312153002213 multimer interface [polypeptide binding]; other site 312153002214 active site 312153002215 catalytic triad [active] 312153002216 protein interface 1 [polypeptide binding]; other site 312153002217 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 312153002218 homodimer interface [polypeptide binding]; other site 312153002219 NAD binding pocket [chemical binding]; other site 312153002220 ATP binding pocket [chemical binding]; other site 312153002221 Mg binding site [ion binding]; other site 312153002222 active-site loop [active] 312153002223 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 312153002224 dimer interface [polypeptide binding]; other site 312153002225 substrate binding site [chemical binding]; other site 312153002226 metal binding sites [ion binding]; metal-binding site 312153002227 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 312153002228 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 312153002229 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 312153002230 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 312153002231 oligomeric interface; other site 312153002232 putative active site [active] 312153002233 homodimer interface [polypeptide binding]; other site 312153002234 thioredoxin reductase; Provisional; Region: PRK10262 312153002235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153002236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153002237 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 312153002238 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 312153002239 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 312153002240 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 312153002241 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 312153002242 seryl-tRNA synthetase; Provisional; Region: PRK05431 312153002243 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 312153002244 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 312153002245 dimer interface [polypeptide binding]; other site 312153002246 active site 312153002247 motif 1; other site 312153002248 motif 2; other site 312153002249 motif 3; other site 312153002250 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 312153002251 putative active site [active] 312153002252 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 312153002253 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 312153002254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153002255 ATP binding site [chemical binding]; other site 312153002256 putative Mg++ binding site [ion binding]; other site 312153002257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153002258 nucleotide binding region [chemical binding]; other site 312153002259 ATP-binding site [chemical binding]; other site 312153002260 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 312153002261 HRDC domain; Region: HRDC; pfam00570 312153002262 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 312153002263 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 312153002264 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 312153002265 active site 312153002266 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 312153002267 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 312153002268 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 312153002269 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 312153002270 active site 312153002271 catalytic site [active] 312153002272 substrate binding site [chemical binding]; other site 312153002273 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 312153002274 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 312153002275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153002276 Walker A motif; other site 312153002277 ATP binding site [chemical binding]; other site 312153002278 Walker B motif; other site 312153002279 arginine finger; other site 312153002280 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 312153002281 hypothetical protein; Validated; Region: PRK00153 312153002282 recombination protein RecR; Reviewed; Region: recR; PRK00076 312153002283 RecR protein; Region: RecR; pfam02132 312153002284 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 312153002285 putative active site [active] 312153002286 putative metal-binding site [ion binding]; other site 312153002287 tetramer interface [polypeptide binding]; other site 312153002288 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 312153002289 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 312153002290 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 312153002291 Catalytic site [active] 312153002292 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 312153002293 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 312153002294 active site 312153002295 DNA binding site [nucleotide binding] 312153002296 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 312153002297 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 312153002298 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 312153002299 Protein of unknown function (DUF465); Region: DUF465; cl01070 312153002300 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 312153002301 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 312153002302 PhnA protein; Region: PhnA; pfam03831 312153002303 AsmA family; Region: AsmA; pfam05170 312153002304 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 312153002305 Membrane protein of unknown function; Region: DUF360; pfam04020 312153002306 SlyX; Region: SlyX; pfam04102 312153002307 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 312153002308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 312153002309 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 312153002310 PIN domain; Region: PIN_3; pfam13470 312153002311 YaeQ protein; Region: YaeQ; pfam07152 312153002312 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 312153002313 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 312153002314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153002315 FeS/SAM binding site; other site 312153002316 HemN C-terminal domain; Region: HemN_C; pfam06969 312153002317 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 312153002318 AAA domain; Region: AAA_33; pfam13671 312153002319 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 312153002320 ABC transporter ATPase component; Reviewed; Region: PRK11147 312153002321 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002323 ABC transporter; Region: ABC_tran_2; pfam12848 312153002324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002325 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 312153002326 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 312153002327 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 312153002328 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 312153002329 HSP70 interaction site [polypeptide binding]; other site 312153002330 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 312153002331 substrate binding site [polypeptide binding]; other site 312153002332 dimer interface [polypeptide binding]; other site 312153002333 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 312153002334 galactarate dehydratase; Region: galactar-dH20; TIGR03248 312153002335 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 312153002336 Pirin-related protein [General function prediction only]; Region: COG1741 312153002337 Pirin; Region: Pirin; pfam02678 312153002338 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 312153002339 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 312153002340 Predicted membrane protein [Function unknown]; Region: COG3223 312153002341 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 312153002342 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 312153002343 Cytochrome c; Region: Cytochrom_C; cl11414 312153002344 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 312153002345 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 312153002346 active site 312153002347 Zn binding site [ion binding]; other site 312153002348 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 312153002349 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 312153002350 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 312153002351 homodimer interface [polypeptide binding]; other site 312153002352 NADP binding site [chemical binding]; other site 312153002353 substrate binding site [chemical binding]; other site 312153002354 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 312153002355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153002356 active site 312153002357 phosphorylation site [posttranslational modification] 312153002358 intermolecular recognition site; other site 312153002359 dimerization interface [polypeptide binding]; other site 312153002360 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 312153002361 DNA binding residues [nucleotide binding] 312153002362 dimerization interface [polypeptide binding]; other site 312153002363 PAS domain S-box; Region: sensory_box; TIGR00229 312153002364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 312153002365 putative active site [active] 312153002366 heme pocket [chemical binding]; other site 312153002367 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 312153002368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153002369 dimer interface [polypeptide binding]; other site 312153002370 phosphorylation site [posttranslational modification] 312153002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153002372 ATP binding site [chemical binding]; other site 312153002373 Mg2+ binding site [ion binding]; other site 312153002374 G-X-G motif; other site 312153002375 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 312153002376 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 312153002377 dimer interface [polypeptide binding]; other site 312153002378 TPP-binding site [chemical binding]; other site 312153002379 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 312153002380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 312153002381 E3 interaction surface; other site 312153002382 lipoyl attachment site [posttranslational modification]; other site 312153002383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 312153002384 E3 interaction surface; other site 312153002385 lipoyl attachment site [posttranslational modification]; other site 312153002386 e3 binding domain; Region: E3_binding; pfam02817 312153002387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 312153002388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 312153002389 E3 interaction surface; other site 312153002390 lipoyl attachment site [posttranslational modification]; other site 312153002391 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 312153002392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153002393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153002394 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 312153002395 Phasin protein; Region: Phasin_2; pfam09361 312153002396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 312153002397 EamA-like transporter family; Region: EamA; pfam00892 312153002398 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 312153002399 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 312153002400 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 312153002401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 312153002402 Bacterial transcriptional regulator; Region: IclR; pfam01614 312153002403 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 312153002404 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 312153002405 quinone interaction residues [chemical binding]; other site 312153002406 active site 312153002407 catalytic residues [active] 312153002408 FMN binding site [chemical binding]; other site 312153002409 substrate binding site [chemical binding]; other site 312153002410 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 312153002411 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 312153002412 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 312153002413 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 312153002414 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 312153002415 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 312153002416 nudix motif; other site 312153002417 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 312153002418 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 312153002419 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 312153002420 homodimer interface [polypeptide binding]; other site 312153002421 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 312153002422 substrate-cofactor binding pocket; other site 312153002423 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 312153002424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153002425 catalytic residue [active] 312153002426 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 312153002427 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 312153002428 substrate binding site [chemical binding]; other site 312153002429 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 312153002430 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 312153002431 recombination factor protein RarA; Reviewed; Region: PRK13342 312153002432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153002433 Walker A motif; other site 312153002434 ATP binding site [chemical binding]; other site 312153002435 Walker B motif; other site 312153002436 arginine finger; other site 312153002437 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 312153002438 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 312153002439 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 312153002440 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 312153002441 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 312153002442 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 312153002443 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 312153002444 C-terminal domain interface [polypeptide binding]; other site 312153002445 GSH binding site (G-site) [chemical binding]; other site 312153002446 dimer interface [polypeptide binding]; other site 312153002447 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 312153002448 N-terminal domain interface [polypeptide binding]; other site 312153002449 putative dimer interface [polypeptide binding]; other site 312153002450 active site 312153002451 methionine aminotransferase; Validated; Region: PRK09082 312153002452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153002453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153002454 homodimer interface [polypeptide binding]; other site 312153002455 catalytic residue [active] 312153002456 hypothetical protein; Validated; Region: PRK02101 312153002457 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 312153002458 malate dehydrogenase; Provisional; Region: PRK05442 312153002459 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 312153002460 NAD(P) binding site [chemical binding]; other site 312153002461 dimer interface [polypeptide binding]; other site 312153002462 malate binding site [chemical binding]; other site 312153002463 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 312153002464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 312153002465 DNA-binding site [nucleotide binding]; DNA binding site 312153002466 UTRA domain; Region: UTRA; pfam07702 312153002467 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 312153002468 Iron-sulfur protein interface; other site 312153002469 proximal quinone binding site [chemical binding]; other site 312153002470 SdhD (CybS) interface [polypeptide binding]; other site 312153002471 proximal heme binding site [chemical binding]; other site 312153002472 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 312153002473 SdhC subunit interface [polypeptide binding]; other site 312153002474 proximal heme binding site [chemical binding]; other site 312153002475 cardiolipin binding site; other site 312153002476 Iron-sulfur protein interface; other site 312153002477 proximal quinone binding site [chemical binding]; other site 312153002478 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 312153002479 L-aspartate oxidase; Provisional; Region: PRK06175 312153002480 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 312153002481 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 312153002482 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 312153002483 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 312153002484 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 312153002485 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 312153002486 dimer interface [polypeptide binding]; other site 312153002487 active site 312153002488 citrylCoA binding site [chemical binding]; other site 312153002489 NADH binding [chemical binding]; other site 312153002490 cationic pore residues; other site 312153002491 oxalacetate/citrate binding site [chemical binding]; other site 312153002492 coenzyme A binding site [chemical binding]; other site 312153002493 catalytic triad [active] 312153002494 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 312153002495 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 312153002496 substrate binding site [chemical binding]; other site 312153002497 ligand binding site [chemical binding]; other site 312153002498 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 312153002499 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 312153002500 substrate binding site [chemical binding]; other site 312153002501 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 312153002502 tartrate dehydrogenase; Region: TTC; TIGR02089 312153002503 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 312153002504 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 312153002505 FimV N-terminal domain; Region: FimV_core; TIGR03505 312153002506 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 312153002507 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 312153002508 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 312153002509 dimerization interface 3.5A [polypeptide binding]; other site 312153002510 active site 312153002511 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 312153002512 active site 312153002513 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 312153002514 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 312153002515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153002516 catalytic residue [active] 312153002517 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 312153002518 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 312153002519 substrate binding site [chemical binding]; other site 312153002520 active site 312153002521 catalytic residues [active] 312153002522 heterodimer interface [polypeptide binding]; other site 312153002523 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 312153002524 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 312153002525 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 312153002526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 312153002527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 312153002528 Sporulation related domain; Region: SPOR; pfam05036 312153002529 Colicin V production protein; Region: Colicin_V; pfam02674 312153002530 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 312153002531 amidophosphoribosyltransferase; Provisional; Region: PRK09246 312153002532 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 312153002533 active site 312153002534 tetramer interface [polypeptide binding]; other site 312153002535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153002536 active site 312153002537 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 312153002538 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 312153002539 homodimer interface [polypeptide binding]; other site 312153002540 substrate-cofactor binding pocket; other site 312153002541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153002542 catalytic residue [active] 312153002543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153002544 S-adenosylmethionine binding site [chemical binding]; other site 312153002545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153002546 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 312153002547 Walker A/P-loop; other site 312153002548 ATP binding site [chemical binding]; other site 312153002549 Q-loop/lid; other site 312153002550 ABC transporter signature motif; other site 312153002551 Walker B; other site 312153002552 D-loop; other site 312153002553 H-loop/switch region; other site 312153002554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153002555 dimer interface [polypeptide binding]; other site 312153002556 conserved gate region; other site 312153002557 putative PBP binding loops; other site 312153002558 ABC-ATPase subunit interface; other site 312153002559 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 312153002560 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 312153002561 ligand binding site [chemical binding]; other site 312153002562 Cytochrome c [Energy production and conversion]; Region: COG3258 312153002563 Cytochrome c; Region: Cytochrom_C; pfam00034 312153002564 Cytochrome c553 [Energy production and conversion]; Region: COG2863 312153002565 Cytochrome c; Region: Cytochrom_C; cl11414 312153002566 putative inner membrane protein; Provisional; Region: PRK11099 312153002567 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 312153002568 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153002569 active site residue [active] 312153002570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153002571 active site residue [active] 312153002572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 312153002573 dimerization interface [polypeptide binding]; other site 312153002574 putative DNA binding site [nucleotide binding]; other site 312153002575 putative Zn2+ binding site [ion binding]; other site 312153002576 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 312153002577 UbiA prenyltransferase family; Region: UbiA; pfam01040 312153002578 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 312153002579 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 312153002580 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 312153002581 ligand binding site [chemical binding]; other site 312153002582 flexible hinge region; other site 312153002583 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 312153002584 High potential iron-sulfur protein; Region: HIPIP; pfam01355 312153002585 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153002586 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 312153002587 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 312153002588 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 312153002589 Moco binding site; other site 312153002590 metal coordination site [ion binding]; other site 312153002591 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 312153002592 Predicted secreted protein [Function unknown]; Region: COG5501 312153002593 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 312153002594 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 312153002595 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 312153002596 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 312153002597 active site 312153002598 metal binding site [ion binding]; metal-binding site 312153002599 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 312153002600 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 312153002601 DsrE/DsrF-like family; Region: DrsE; cl00672 312153002602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 312153002603 Predicted transporter component [General function prediction only]; Region: COG2391 312153002604 Sulphur transport; Region: Sulf_transp; pfam04143 312153002605 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 312153002606 Predicted transporter component [General function prediction only]; Region: COG2391 312153002607 Predicted transporter component [General function prediction only]; Region: COG2391 312153002608 Sulphur transport; Region: Sulf_transp; pfam04143 312153002609 Putative phosphatase (DUF442); Region: DUF442; cl17385 312153002610 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 312153002611 active site 312153002612 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 312153002613 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153002614 active site residue [active] 312153002615 AAA domain; Region: AAA_17; pfam13207 312153002616 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153002617 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 312153002618 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153002619 Cytochrome c [Energy production and conversion]; Region: COG3258 312153002620 Cytochrome c; Region: Cytochrom_C; pfam00034 312153002621 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 312153002622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 312153002623 FAD binding site [chemical binding]; other site 312153002624 substrate binding pocket [chemical binding]; other site 312153002625 catalytic base [active] 312153002626 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 312153002627 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 312153002628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002630 ABC transporter; Region: ABC_tran_2; pfam12848 312153002631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 312153002632 Predicted Fe-S protein [General function prediction only]; Region: COG3313 312153002633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 312153002634 Protein of unknown function, DUF482; Region: DUF482; pfam04339 312153002635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 312153002636 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 312153002637 dimer interface [polypeptide binding]; other site 312153002638 active site 312153002639 metal binding site [ion binding]; metal-binding site 312153002640 glutathione binding site [chemical binding]; other site 312153002641 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 312153002642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 312153002643 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 312153002644 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 312153002645 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 312153002646 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 312153002647 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 312153002648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 312153002649 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 312153002650 HD domain; Region: HD_4; pfam13328 312153002651 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 312153002652 synthetase active site [active] 312153002653 NTP binding site [chemical binding]; other site 312153002654 metal binding site [ion binding]; metal-binding site 312153002655 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 312153002656 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 312153002657 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 312153002658 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 312153002659 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 312153002660 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 312153002661 active site 312153002662 dimer interface [polypeptide binding]; other site 312153002663 motif 1; other site 312153002664 motif 2; other site 312153002665 motif 3; other site 312153002666 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 312153002667 anticodon binding site; other site 312153002668 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 312153002669 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 312153002670 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 312153002671 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 312153002672 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 312153002673 23S rRNA binding site [nucleotide binding]; other site 312153002674 L21 binding site [polypeptide binding]; other site 312153002675 L13 binding site [polypeptide binding]; other site 312153002676 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 312153002677 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 312153002678 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 312153002679 dimer interface [polypeptide binding]; other site 312153002680 motif 1; other site 312153002681 active site 312153002682 motif 2; other site 312153002683 motif 3; other site 312153002684 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 312153002685 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 312153002686 putative tRNA-binding site [nucleotide binding]; other site 312153002687 B3/4 domain; Region: B3_4; pfam03483 312153002688 tRNA synthetase B5 domain; Region: B5; smart00874 312153002689 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 312153002690 dimer interface [polypeptide binding]; other site 312153002691 motif 1; other site 312153002692 motif 3; other site 312153002693 motif 2; other site 312153002694 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 312153002695 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 312153002696 IHF - DNA interface [nucleotide binding]; other site 312153002697 IHF dimer interface [polypeptide binding]; other site 312153002698 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 312153002699 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 312153002700 DNA binding residues [nucleotide binding] 312153002701 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 312153002702 CoenzymeA binding site [chemical binding]; other site 312153002703 subunit interaction site [polypeptide binding]; other site 312153002704 PHB binding site; other site 312153002705 H-NS histone family; Region: Histone_HNS; pfam00816 312153002706 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 312153002707 Helix-turn-helix domain; Region: HTH_17; pfam12728 312153002708 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 312153002709 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 312153002710 TPP-binding site [chemical binding]; other site 312153002711 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 312153002712 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 312153002713 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 312153002714 E3 interaction surface; other site 312153002715 lipoyl attachment site [posttranslational modification]; other site 312153002716 e3 binding domain; Region: E3_binding; pfam02817 312153002717 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 312153002718 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 312153002719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153002720 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 312153002721 Predicted ATPase [General function prediction only]; Region: COG1485 312153002722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153002723 Walker A/P-loop; other site 312153002724 ATP binding site [chemical binding]; other site 312153002725 Q-loop/lid; other site 312153002726 ABC transporter signature motif; other site 312153002727 Walker B; other site 312153002728 D-loop; other site 312153002729 H-loop/switch region; other site 312153002730 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 312153002731 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 312153002732 active site 312153002733 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 312153002734 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 312153002735 active site 312153002736 HIGH motif; other site 312153002737 dimer interface [polypeptide binding]; other site 312153002738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153002739 active site 312153002740 KMSKS motif; other site 312153002741 Methyltransferase domain; Region: Methyltransf_23; pfam13489 312153002742 Methyltransferase domain; Region: Methyltransf_18; pfam12847 312153002743 S-adenosylmethionine binding site [chemical binding]; other site 312153002744 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 312153002745 dihydrodipicolinate synthase; Region: dapA; TIGR00674 312153002746 dimer interface [polypeptide binding]; other site 312153002747 active site 312153002748 catalytic residue [active] 312153002749 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 312153002750 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 312153002751 Uncharacterized conserved protein [Function unknown]; Region: COG2850 312153002752 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 312153002753 serine O-acetyltransferase; Region: cysE; TIGR01172 312153002754 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 312153002755 trimer interface [polypeptide binding]; other site 312153002756 active site 312153002757 substrate binding site [chemical binding]; other site 312153002758 CoA binding site [chemical binding]; other site 312153002759 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 312153002760 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 312153002761 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 312153002762 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 312153002763 active site 312153002764 dimerization interface [polypeptide binding]; other site 312153002765 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 312153002766 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 312153002767 putative active site [active] 312153002768 putative metal binding site [ion binding]; other site 312153002769 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 312153002770 substrate binding site [chemical binding]; other site 312153002771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153002772 binding surface 312153002773 TPR motif; other site 312153002774 TPR repeat; Region: TPR_11; pfam13414 312153002775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153002776 binding surface 312153002777 TPR motif; other site 312153002778 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 312153002779 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 312153002780 active site 312153002781 HIGH motif; other site 312153002782 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 312153002783 KMSKS motif; other site 312153002784 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 312153002785 tRNA binding surface [nucleotide binding]; other site 312153002786 anticodon binding site; other site 312153002787 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 312153002788 endonuclease III; Region: ENDO3c; smart00478 312153002789 minor groove reading motif; other site 312153002790 helix-hairpin-helix signature motif; other site 312153002791 substrate binding pocket [chemical binding]; other site 312153002792 active site 312153002793 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 312153002794 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 312153002795 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 312153002796 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 312153002797 Ligand Binding Site [chemical binding]; other site 312153002798 TilS substrate binding domain; Region: TilS; pfam09179 312153002799 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 312153002800 aspartate kinase; Reviewed; Region: PRK06635 312153002801 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 312153002802 putative nucleotide binding site [chemical binding]; other site 312153002803 putative catalytic residues [active] 312153002804 putative Mg ion binding site [ion binding]; other site 312153002805 putative aspartate binding site [chemical binding]; other site 312153002806 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 312153002807 putative allosteric regulatory site; other site 312153002808 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 312153002809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 312153002810 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 312153002811 putative active site [active] 312153002812 putative metal binding site [ion binding]; other site 312153002813 HipA N-terminal domain; Region: Couple_hipA; cl11853 312153002814 HipA-like N-terminal domain; Region: HipA_N; pfam07805 312153002815 HipA-like C-terminal domain; Region: HipA_C; pfam07804 312153002816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 312153002817 non-specific DNA binding site [nucleotide binding]; other site 312153002818 salt bridge; other site 312153002819 sequence-specific DNA binding site [nucleotide binding]; other site 312153002820 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 312153002821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 312153002822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 312153002823 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 312153002824 Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment; Region: Ribosomal_L19e; cl00232 312153002825 Protein export membrane protein; Region: SecD_SecF; cl14618 312153002826 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 312153002827 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153002828 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 312153002829 active site 312153002830 catalytic residues [active] 312153002831 metal binding site [ion binding]; metal-binding site 312153002832 Smr domain; Region: Smr; pfam01713 312153002833 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 312153002834 Predicted membrane protein [Function unknown]; Region: COG5393 312153002835 YqjK-like protein; Region: YqjK; pfam13997 312153002836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153002837 active site 312153002838 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 312153002839 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 312153002840 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 312153002841 acyl-activating enzyme (AAE) consensus motif; other site 312153002842 putative AMP binding site [chemical binding]; other site 312153002843 putative active site [active] 312153002844 putative CoA binding site [chemical binding]; other site 312153002845 dihydroxy-acid dehydratase; Validated; Region: PRK06131 312153002846 putative protease; Provisional; Region: PRK15452 312153002847 Peptidase family U32; Region: Peptidase_U32; pfam01136 312153002848 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 312153002849 dimer interface [polypeptide binding]; other site 312153002850 substrate binding site [chemical binding]; other site 312153002851 ATP binding site [chemical binding]; other site 312153002852 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 312153002853 thiamine phosphate binding site [chemical binding]; other site 312153002854 active site 312153002855 pyrophosphate binding site [ion binding]; other site 312153002856 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 312153002857 ThiS interaction site; other site 312153002858 putative active site [active] 312153002859 tetramer interface [polypeptide binding]; other site 312153002860 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 312153002861 thiS-thiF/thiG interaction site; other site 312153002862 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 312153002863 hydroxyglutarate oxidase; Provisional; Region: PRK11728 312153002864 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 312153002865 ThiC-associated domain; Region: ThiC-associated; pfam13667 312153002866 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 312153002867 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 312153002868 nudix motif; other site 312153002869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153002870 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 312153002871 putative substrate translocation pore; other site 312153002872 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 312153002873 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153002874 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 312153002875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153002876 ATP binding site [chemical binding]; other site 312153002877 Mg2+ binding site [ion binding]; other site 312153002878 G-X-G motif; other site 312153002879 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 312153002880 anchoring element; other site 312153002881 dimer interface [polypeptide binding]; other site 312153002882 ATP binding site [chemical binding]; other site 312153002883 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 312153002884 active site 312153002885 metal binding site [ion binding]; metal-binding site 312153002886 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 312153002887 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 312153002888 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 312153002889 CAP-like domain; other site 312153002890 active site 312153002891 primary dimer interface [polypeptide binding]; other site 312153002892 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 312153002893 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 312153002894 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 312153002895 XdhC Rossmann domain; Region: XdhC_C; pfam13478 312153002896 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 312153002897 Ligand binding site; other site 312153002898 metal-binding site 312153002899 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 312153002900 homotrimer interaction site [polypeptide binding]; other site 312153002901 putative active site [active] 312153002902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 312153002903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153002904 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 312153002905 Walker A motif; other site 312153002906 ATP binding site [chemical binding]; other site 312153002907 Walker B motif; other site 312153002908 arginine finger; other site 312153002909 Cytochrome c553 [Energy production and conversion]; Region: COG2863 312153002910 Cytochrome c553 [Energy production and conversion]; Region: COG2863 312153002911 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153002912 Transcriptional regulators [Transcription]; Region: GntR; COG1802 312153002913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 312153002914 DNA-binding site [nucleotide binding]; DNA binding site 312153002915 FCD domain; Region: FCD; pfam07729 312153002916 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 312153002917 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 312153002918 active site 312153002919 substrate binding site [chemical binding]; other site 312153002920 coenzyme B12 binding site [chemical binding]; other site 312153002921 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 312153002922 B12 binding site [chemical binding]; other site 312153002923 cobalt ligand [ion binding]; other site 312153002924 membrane ATPase/protein kinase; Provisional; Region: PRK09435 312153002925 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 312153002926 Walker A; other site 312153002927 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 312153002928 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 312153002929 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 312153002930 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 312153002931 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 312153002932 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 312153002933 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 312153002934 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 312153002935 carboxyltransferase (CT) interaction site; other site 312153002936 biotinylation site [posttranslational modification]; other site 312153002937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 312153002938 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 312153002939 dimer interface [polypeptide binding]; other site 312153002940 substrate binding site [chemical binding]; other site 312153002941 metal binding site [ion binding]; metal-binding site 312153002942 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 312153002943 Glycoprotease family; Region: Peptidase_M22; pfam00814 312153002944 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 312153002945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153002946 Coenzyme A binding pocket [chemical binding]; other site 312153002947 lysophospholipid transporter LplT; Provisional; Region: PRK11195 312153002948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 312153002949 alanine racemase; Reviewed; Region: dadX; PRK03646 312153002950 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 312153002951 active site 312153002952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 312153002953 substrate binding site [chemical binding]; other site 312153002954 catalytic residues [active] 312153002955 dimer interface [polypeptide binding]; other site 312153002956 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 312153002957 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 312153002958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153002959 RNA binding surface [nucleotide binding]; other site 312153002960 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 312153002961 active site 312153002962 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 312153002963 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 312153002964 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 312153002965 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 312153002966 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 312153002967 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 312153002968 NAD(P) binding site [chemical binding]; other site 312153002969 homotetramer interface [polypeptide binding]; other site 312153002970 homodimer interface [polypeptide binding]; other site 312153002971 active site 312153002972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 312153002973 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 312153002974 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 312153002975 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 312153002976 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 312153002977 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 312153002978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153002979 FeS/SAM binding site; other site 312153002980 beta-ketothiolase; Provisional; Region: PRK09051 312153002981 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 312153002982 dimer interface [polypeptide binding]; other site 312153002983 active site 312153002984 phosphoserine phosphatase SerB; Region: serB; TIGR00338 312153002985 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 312153002986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 312153002987 motif II; other site 312153002988 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 312153002989 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 312153002990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153002991 ATP binding site [chemical binding]; other site 312153002992 putative Mg++ binding site [ion binding]; other site 312153002993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153002994 nucleotide binding region [chemical binding]; other site 312153002995 ATP-binding site [chemical binding]; other site 312153002996 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 312153002997 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 312153002998 substrate binding site; other site 312153002999 dimer interface; other site 312153003000 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 312153003001 homotrimer interaction site [polypeptide binding]; other site 312153003002 zinc binding site [ion binding]; other site 312153003003 CDP-binding sites; other site 312153003004 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 312153003005 putative FMN binding site [chemical binding]; other site 312153003006 trigger factor; Provisional; Region: tig; PRK01490 312153003007 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 312153003008 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 312153003009 Clp protease; Region: CLP_protease; pfam00574 312153003010 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 312153003011 oligomer interface [polypeptide binding]; other site 312153003012 active site residues [active] 312153003013 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 312153003014 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 312153003015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153003016 Walker A motif; other site 312153003017 ATP binding site [chemical binding]; other site 312153003018 Walker B motif; other site 312153003019 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 312153003020 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 312153003021 Found in ATP-dependent protease La (LON); Region: LON; smart00464 312153003022 Found in ATP-dependent protease La (LON); Region: LON; smart00464 312153003023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153003024 Walker A motif; other site 312153003025 ATP binding site [chemical binding]; other site 312153003026 Walker B motif; other site 312153003027 arginine finger; other site 312153003028 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 312153003029 SurA N-terminal domain; Region: SurA_N_3; cl07813 312153003030 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 312153003031 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 312153003032 active site 312153003033 catalytic triad [active] 312153003034 oxyanion hole [active] 312153003035 switch loop; other site 312153003036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 312153003037 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 312153003038 Walker A/P-loop; other site 312153003039 ATP binding site [chemical binding]; other site 312153003040 Q-loop/lid; other site 312153003041 ABC transporter signature motif; other site 312153003042 Walker B; other site 312153003043 D-loop; other site 312153003044 H-loop/switch region; other site 312153003045 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 312153003046 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 312153003047 dimerization interface [polypeptide binding]; other site 312153003048 ATP binding site [chemical binding]; other site 312153003049 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 312153003050 dimerization interface [polypeptide binding]; other site 312153003051 ATP binding site [chemical binding]; other site 312153003052 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 312153003053 putative active site [active] 312153003054 catalytic triad [active] 312153003055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153003056 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 312153003057 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 312153003058 substrate binding site [chemical binding]; other site 312153003059 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 312153003060 substrate binding site [chemical binding]; other site 312153003061 ligand binding site [chemical binding]; other site 312153003062 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 312153003063 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 312153003064 CTP synthetase; Validated; Region: pyrG; PRK05380 312153003065 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 312153003066 Catalytic site [active] 312153003067 active site 312153003068 UTP binding site [chemical binding]; other site 312153003069 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 312153003070 active site 312153003071 putative oxyanion hole; other site 312153003072 catalytic triad [active] 312153003073 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 312153003074 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 312153003075 enolase; Provisional; Region: eno; PRK00077 312153003076 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 312153003077 dimer interface [polypeptide binding]; other site 312153003078 metal binding site [ion binding]; metal-binding site 312153003079 substrate binding pocket [chemical binding]; other site 312153003080 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 312153003081 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 312153003082 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 312153003083 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 312153003084 dimerization interface [polypeptide binding]; other site 312153003085 domain crossover interface; other site 312153003086 redox-dependent activation switch; other site 312153003087 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 312153003088 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 312153003089 active site 312153003090 HIGH motif; other site 312153003091 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 312153003092 active site 312153003093 KMSKS motif; other site 312153003094 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 312153003095 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 312153003096 Esterase/lipase [General function prediction only]; Region: COG1647 312153003097 A new structural DNA glycosylase; Region: AlkD_like; cl11434 312153003098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 312153003099 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 312153003100 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 312153003101 dimer interface [polypeptide binding]; other site 312153003102 active site 312153003103 tartronate semialdehyde reductase; Provisional; Region: PRK15059 312153003104 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 312153003105 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 312153003106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 312153003107 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 312153003108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 312153003109 active site 312153003110 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 312153003111 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 312153003112 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 312153003113 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 312153003114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 312153003115 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 312153003116 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 312153003117 active site 312153003118 DNA polymerase III subunit delta'; Validated; Region: PRK06964 312153003119 DNA polymerase III subunit delta'; Validated; Region: PRK08485 312153003120 thymidylate kinase; Validated; Region: tmk; PRK00698 312153003121 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 312153003122 TMP-binding site; other site 312153003123 ATP-binding site [chemical binding]; other site 312153003124 YceG-like family; Region: YceG; pfam02618 312153003125 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 312153003126 dimerization interface [polypeptide binding]; other site 312153003127 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 312153003128 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 312153003129 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 312153003130 NRDE protein; Region: NRDE; cl01315 312153003131 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 312153003132 CoenzymeA binding site [chemical binding]; other site 312153003133 subunit interaction site [polypeptide binding]; other site 312153003134 PHB binding site; other site 312153003135 Uncharacterized conserved protein [Function unknown]; Region: COG0397 312153003136 hypothetical protein; Validated; Region: PRK00029 312153003137 methionine sulfoxide reductase B; Provisional; Region: PRK00222 312153003138 SelR domain; Region: SelR; pfam01641 312153003139 intracellular septation protein A; Reviewed; Region: PRK00259 312153003140 BolA-like protein; Region: BolA; pfam01722 312153003141 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 312153003142 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 312153003143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153003144 putative substrate translocation pore; other site 312153003145 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 312153003146 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 312153003147 Tetramer interface [polypeptide binding]; other site 312153003148 active site 312153003149 FMN-binding site [chemical binding]; other site 312153003150 FOG: CBS domain [General function prediction only]; Region: COG0517 312153003151 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 312153003152 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 312153003153 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 312153003154 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 312153003155 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 312153003156 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 312153003157 FAD binding domain; Region: FAD_binding_4; pfam01565 312153003158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 312153003159 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 312153003160 Ca2+ binding site [ion binding]; other site 312153003161 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 312153003162 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 312153003163 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 312153003164 Walker A/P-loop; other site 312153003165 ATP binding site [chemical binding]; other site 312153003166 Q-loop/lid; other site 312153003167 ABC transporter signature motif; other site 312153003168 Walker B; other site 312153003169 D-loop; other site 312153003170 H-loop/switch region; other site 312153003171 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 312153003172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003173 dimer interface [polypeptide binding]; other site 312153003174 conserved gate region; other site 312153003175 putative PBP binding loops; other site 312153003176 ABC-ATPase subunit interface; other site 312153003177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003178 dimer interface [polypeptide binding]; other site 312153003179 conserved gate region; other site 312153003180 putative PBP binding loops; other site 312153003181 ABC-ATPase subunit interface; other site 312153003182 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 312153003183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 312153003184 substrate binding pocket [chemical binding]; other site 312153003185 membrane-bound complex binding site; other site 312153003186 hinge residues; other site 312153003187 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 312153003188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153003189 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 312153003190 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153003191 active site 312153003192 PAS domain S-box; Region: sensory_box; TIGR00229 312153003193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 312153003194 putative active site [active] 312153003195 heme pocket [chemical binding]; other site 312153003196 cyanate hydratase; Validated; Region: PRK02866 312153003197 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 312153003198 oligomer interface [polypeptide binding]; other site 312153003199 active site 312153003200 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 312153003201 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 312153003202 Walker A/P-loop; other site 312153003203 ATP binding site [chemical binding]; other site 312153003204 Q-loop/lid; other site 312153003205 ABC transporter signature motif; other site 312153003206 Walker B; other site 312153003207 D-loop; other site 312153003208 H-loop/switch region; other site 312153003209 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 312153003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003211 dimer interface [polypeptide binding]; other site 312153003212 conserved gate region; other site 312153003213 putative PBP binding loops; other site 312153003214 ABC-ATPase subunit interface; other site 312153003215 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 312153003216 NMT1-like family; Region: NMT1_2; pfam13379 312153003217 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 312153003218 active site 312153003219 SAM binding site [chemical binding]; other site 312153003220 homodimer interface [polypeptide binding]; other site 312153003221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 312153003222 NMT1-like family; Region: NMT1_2; pfam13379 312153003223 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 312153003224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153003225 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 312153003226 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 312153003227 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 312153003228 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 312153003229 [2Fe-2S] cluster binding site [ion binding]; other site 312153003230 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 312153003231 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 312153003232 molybdopterin cofactor binding site; other site 312153003233 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 312153003234 molybdopterin cofactor binding site; other site 312153003235 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 312153003236 glycosyl transferase family protein; Provisional; Region: PRK08136 312153003237 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 312153003238 HPP family; Region: HPP; pfam04982 312153003239 HPP family; Region: HPP; pfam04982 312153003240 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 312153003241 HPP family; Region: HPP; pfam04982 312153003242 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 312153003243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 312153003244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 312153003245 SnoaL-like domain; Region: SnoaL_2; pfam12680 312153003246 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 312153003247 putative FMN binding site [chemical binding]; other site 312153003248 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 312153003249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 312153003250 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 312153003251 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 312153003252 active site 312153003253 substrate binding site [chemical binding]; other site 312153003254 metal binding site [ion binding]; metal-binding site 312153003255 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 312153003256 dihydropteroate synthase; Region: DHPS; TIGR01496 312153003257 substrate binding pocket [chemical binding]; other site 312153003258 dimer interface [polypeptide binding]; other site 312153003259 inhibitor binding site; inhibition site 312153003260 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 312153003261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153003262 Walker A motif; other site 312153003263 ATP binding site [chemical binding]; other site 312153003264 Walker B motif; other site 312153003265 arginine finger; other site 312153003266 Peptidase family M41; Region: Peptidase_M41; pfam01434 312153003267 FtsJ-like methyltransferase; Region: FtsJ; cl17430 312153003268 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 312153003269 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 312153003270 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 312153003271 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 312153003272 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 312153003273 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 312153003274 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 312153003275 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 312153003276 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 312153003277 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 312153003278 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 312153003279 ATP-grasp domain; Region: ATP-grasp_4; cl17255 312153003280 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 312153003281 IMP binding site; other site 312153003282 dimer interface [polypeptide binding]; other site 312153003283 interdomain contacts; other site 312153003284 partial ornithine binding site; other site 312153003285 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 312153003286 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 312153003287 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 312153003288 catalytic site [active] 312153003289 subunit interface [polypeptide binding]; other site 312153003290 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 312153003291 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 312153003292 acyl-activating enzyme (AAE) consensus motif; other site 312153003293 AMP binding site [chemical binding]; other site 312153003294 active site 312153003295 CoA binding site [chemical binding]; other site 312153003296 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 312153003297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 312153003298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 312153003299 catalytic residue [active] 312153003300 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 312153003301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153003302 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 312153003303 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 312153003304 RNA/DNA hybrid binding site [nucleotide binding]; other site 312153003305 active site 312153003306 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 312153003307 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 312153003308 HlyD family secretion protein; Region: HlyD_3; pfam13437 312153003309 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 312153003310 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 312153003311 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 312153003312 active site 312153003313 catalytic site [active] 312153003314 substrate binding site [chemical binding]; other site 312153003315 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 312153003316 tartrate dehydrogenase; Region: TTC; TIGR02089 312153003317 SprT-like family; Region: SprT-like; pfam10263 312153003318 SprT homologues; Region: SprT; cl01182 312153003319 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 312153003320 Amidase; Region: Amidase; cl11426 312153003321 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153003322 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 312153003323 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 312153003324 active site 312153003325 FMN binding site [chemical binding]; other site 312153003326 substrate binding site [chemical binding]; other site 312153003327 homotetramer interface [polypeptide binding]; other site 312153003328 catalytic residue [active] 312153003329 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 312153003330 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 312153003331 tetrameric interface [polypeptide binding]; other site 312153003332 NAD binding site [chemical binding]; other site 312153003333 catalytic residues [active] 312153003334 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 312153003335 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 312153003336 dimer interface [polypeptide binding]; other site 312153003337 ADP-ribose binding site [chemical binding]; other site 312153003338 active site 312153003339 nudix motif; other site 312153003340 metal binding site [ion binding]; metal-binding site 312153003341 NADH dehydrogenase subunit 2; Validated; Region: ND2; MTH00041 312153003342 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 312153003343 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 312153003344 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 312153003345 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 312153003346 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 312153003347 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 312153003348 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 312153003349 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 312153003350 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 312153003351 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 312153003352 4Fe-4S binding domain; Region: Fer4; pfam00037 312153003353 4Fe-4S binding domain; Region: Fer4; pfam00037 312153003354 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 312153003355 NADH dehydrogenase subunit G; Validated; Region: PRK09129 312153003356 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153003357 catalytic loop [active] 312153003358 iron binding site [ion binding]; other site 312153003359 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 312153003360 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 312153003361 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 312153003362 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 312153003363 SLBB domain; Region: SLBB; pfam10531 312153003364 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 312153003365 NADH dehydrogenase subunit E; Validated; Region: PRK07539 312153003366 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 312153003367 putative dimer interface [polypeptide binding]; other site 312153003368 [2Fe-2S] cluster binding site [ion binding]; other site 312153003369 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 312153003370 NADH dehydrogenase subunit D; Validated; Region: PRK06075 312153003371 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 312153003372 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 312153003373 NADH dehydrogenase subunit B; Validated; Region: PRK06411 312153003374 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 312153003375 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 312153003376 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 312153003377 triosephosphate isomerase; Provisional; Region: PRK14567 312153003378 substrate binding site [chemical binding]; other site 312153003379 dimer interface [polypeptide binding]; other site 312153003380 catalytic triad [active] 312153003381 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 312153003382 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 312153003383 NAD(P) binding site [chemical binding]; other site 312153003384 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 312153003385 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 312153003386 RNase E interface [polypeptide binding]; other site 312153003387 trimer interface [polypeptide binding]; other site 312153003388 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 312153003389 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 312153003390 RNase E interface [polypeptide binding]; other site 312153003391 trimer interface [polypeptide binding]; other site 312153003392 active site 312153003393 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 312153003394 putative nucleic acid binding region [nucleotide binding]; other site 312153003395 G-X-X-G motif; other site 312153003396 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 312153003397 RNA binding site [nucleotide binding]; other site 312153003398 domain interface; other site 312153003399 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 312153003400 16S/18S rRNA binding site [nucleotide binding]; other site 312153003401 S13e-L30e interaction site [polypeptide binding]; other site 312153003402 25S rRNA binding site [nucleotide binding]; other site 312153003403 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 312153003404 2-isopropylmalate synthase; Validated; Region: PRK00915 312153003405 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 312153003406 active site 312153003407 catalytic residues [active] 312153003408 metal binding site [ion binding]; metal-binding site 312153003409 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 312153003410 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 312153003411 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 312153003412 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 312153003413 ketol-acid reductoisomerase; Provisional; Region: PRK05479 312153003414 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 312153003415 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 312153003416 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 312153003417 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 312153003418 putative valine binding site [chemical binding]; other site 312153003419 dimer interface [polypeptide binding]; other site 312153003420 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 312153003421 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 312153003422 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 312153003423 PYR/PP interface [polypeptide binding]; other site 312153003424 dimer interface [polypeptide binding]; other site 312153003425 TPP binding site [chemical binding]; other site 312153003426 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 312153003427 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 312153003428 TPP-binding site [chemical binding]; other site 312153003429 dimer interface [polypeptide binding]; other site 312153003430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 312153003431 RNA polymerase factor sigma-70; Validated; Region: PRK09047 312153003432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 312153003433 DNA binding residues [nucleotide binding] 312153003434 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 312153003435 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 312153003436 RDD family; Region: RDD; pfam06271 312153003437 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 312153003438 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 312153003439 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 312153003440 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 312153003441 putative NAD(P) binding site [chemical binding]; other site 312153003442 putative active site [active] 312153003443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 312153003444 Protein of unknown function (DUF330); Region: DUF330; cl01135 312153003445 mce related protein; Region: MCE; pfam02470 312153003446 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 312153003447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153003448 Walker A/P-loop; other site 312153003449 ATP binding site [chemical binding]; other site 312153003450 Q-loop/lid; other site 312153003451 ABC transporter signature motif; other site 312153003452 Walker B; other site 312153003453 D-loop; other site 312153003454 H-loop/switch region; other site 312153003455 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 312153003456 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 312153003457 Permease; Region: Permease; pfam02405 312153003458 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 312153003459 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 312153003460 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 312153003461 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 312153003462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 312153003463 Zn2+ binding site [ion binding]; other site 312153003464 Mg2+ binding site [ion binding]; other site 312153003465 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 312153003466 synthetase active site [active] 312153003467 NTP binding site [chemical binding]; other site 312153003468 metal binding site [ion binding]; metal-binding site 312153003469 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 312153003470 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 312153003471 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 312153003472 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 312153003473 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 312153003474 catalytic site [active] 312153003475 G-X2-G-X-G-K; other site 312153003476 hypothetical protein; Provisional; Region: PRK11820 312153003477 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 312153003478 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 312153003479 ribonuclease PH; Reviewed; Region: rph; PRK00173 312153003480 Ribonuclease PH; Region: RNase_PH_bact; cd11362 312153003481 hexamer interface [polypeptide binding]; other site 312153003482 active site 312153003483 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 312153003484 active site 312153003485 dimerization interface [polypeptide binding]; other site 312153003486 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 312153003487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153003488 FeS/SAM binding site; other site 312153003489 HemN C-terminal domain; Region: HemN_C; pfam06969 312153003490 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153003491 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 312153003492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 312153003493 SCP-2 sterol transfer family; Region: SCP2; pfam02036 312153003494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 312153003495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153003496 dimer interface [polypeptide binding]; other site 312153003497 phosphorylation site [posttranslational modification] 312153003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153003499 ATP binding site [chemical binding]; other site 312153003500 Mg2+ binding site [ion binding]; other site 312153003501 G-X-G motif; other site 312153003502 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 312153003503 nucleophile elbow; other site 312153003504 benzoylformate decarboxylase; Reviewed; Region: PRK07092 312153003505 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 312153003506 PYR/PP interface [polypeptide binding]; other site 312153003507 dimer interface [polypeptide binding]; other site 312153003508 TPP binding site [chemical binding]; other site 312153003509 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 312153003510 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 312153003511 TPP-binding site [chemical binding]; other site 312153003512 dimer interface [polypeptide binding]; other site 312153003513 hydroxyglutarate oxidase; Provisional; Region: PRK11728 312153003514 Predicted dehydrogenase [General function prediction only]; Region: COG0579 312153003515 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 312153003516 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 312153003517 active site 312153003518 dimer interface [polypeptide binding]; other site 312153003519 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 312153003520 dimer interface [polypeptide binding]; other site 312153003521 active site 312153003522 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 312153003523 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 312153003524 active site 312153003525 substrate binding site [chemical binding]; other site 312153003526 metal binding site [ion binding]; metal-binding site 312153003527 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 312153003528 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 312153003529 Surface antigen; Region: Bac_surface_Ag; pfam01103 312153003530 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 312153003531 Autotransporter beta-domain; Region: Autotransporter; smart00869 312153003532 Tetratricopeptide repeat; Region: TPR_16; pfam13432 312153003533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003534 TPR motif; other site 312153003535 binding surface 312153003536 TPR repeat; Region: TPR_11; pfam13414 312153003537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 312153003538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003539 binding surface 312153003540 TPR motif; other site 312153003541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003542 binding surface 312153003543 TPR motif; other site 312153003544 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 312153003545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003546 TPR motif; other site 312153003547 TPR repeat; Region: TPR_11; pfam13414 312153003548 binding surface 312153003549 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153003550 Tetratricopeptide repeat; Region: TPR_16; pfam13432 312153003551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003552 TPR motif; other site 312153003553 binding surface 312153003554 TPR repeat; Region: TPR_11; pfam13414 312153003555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003556 TPR motif; other site 312153003557 binding surface 312153003558 Tetratricopeptide repeat; Region: TPR_12; pfam13424 312153003559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003560 binding surface 312153003561 TPR motif; other site 312153003562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003563 binding surface 312153003564 TPR motif; other site 312153003565 TPR repeat; Region: TPR_11; pfam13414 312153003566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003567 binding surface 312153003568 TPR motif; other site 312153003569 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 312153003570 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 312153003571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153003572 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 312153003573 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 312153003574 ligand-binding site [chemical binding]; other site 312153003575 Peptidase family M48; Region: Peptidase_M48; cl12018 312153003576 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 312153003577 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 312153003578 quinolinate synthetase; Provisional; Region: PRK09375 312153003579 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 312153003580 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 312153003581 dimerization interface [polypeptide binding]; other site 312153003582 active site 312153003583 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 312153003584 L-aspartate oxidase; Provisional; Region: PRK09077 312153003585 L-aspartate oxidase; Provisional; Region: PRK06175 312153003586 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 312153003587 PemK-like protein; Region: PemK; cl00995 312153003588 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 312153003589 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 312153003590 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153003591 catalytic loop [active] 312153003592 iron binding site [ion binding]; other site 312153003593 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 312153003594 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 312153003595 [4Fe-4S] binding site [ion binding]; other site 312153003596 molybdopterin cofactor binding site; other site 312153003597 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 312153003598 molybdopterin cofactor binding site; other site 312153003599 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 312153003600 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 312153003601 putative dimer interface [polypeptide binding]; other site 312153003602 [2Fe-2S] cluster binding site [ion binding]; other site 312153003603 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 312153003604 SLBB domain; Region: SLBB; pfam10531 312153003605 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 312153003606 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 312153003607 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 312153003608 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 312153003609 Predicted transcriptional regulator [Transcription]; Region: COG4190 312153003610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 312153003611 putative DNA binding site [nucleotide binding]; other site 312153003612 putative Zn2+ binding site [ion binding]; other site 312153003613 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 312153003614 YciI-like protein; Reviewed; Region: PRK12863 312153003615 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 312153003616 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 312153003617 active site 312153003618 Int/Topo IB signature motif; other site 312153003619 AAA domain; Region: AAA_21; pfam13304 312153003620 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 312153003621 active site 312153003622 catalytic site [active] 312153003623 substrate binding site [chemical binding]; other site 312153003624 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 312153003625 Fic/DOC family; Region: Fic; pfam02661 312153003626 Terminase-like family; Region: Terminase_6; pfam03237 312153003627 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 312153003628 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 312153003629 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 312153003630 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 312153003631 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 312153003632 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 312153003633 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 312153003634 HsdM N-terminal domain; Region: HsdM_N; pfam12161 312153003635 Methyltransferase domain; Region: Methyltransf_26; pfam13659 312153003636 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 312153003637 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 312153003638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153003639 ATP binding site [chemical binding]; other site 312153003640 putative Mg++ binding site [ion binding]; other site 312153003641 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 312153003642 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 312153003643 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 312153003644 acetyl-CoA synthetase; Provisional; Region: PRK00174 312153003645 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 312153003646 active site 312153003647 CoA binding site [chemical binding]; other site 312153003648 acyl-activating enzyme (AAE) consensus motif; other site 312153003649 AMP binding site [chemical binding]; other site 312153003650 acetate binding site [chemical binding]; other site 312153003651 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 312153003652 Fumarase C-terminus; Region: Fumerase_C; pfam05683 312153003653 glutamate racemase; Provisional; Region: PRK00865 312153003654 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 312153003655 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 312153003656 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 312153003657 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 312153003658 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 312153003659 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 312153003660 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 312153003661 PBP superfamily domain; Region: PBP_like_2; cl17296 312153003662 PBP superfamily domain; Region: PBP_like_2; cl17296 312153003663 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 312153003664 haemagglutination activity domain; Region: Haemagg_act; pfam05860 312153003665 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 312153003666 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153003667 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 312153003668 active site 312153003669 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 312153003670 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 312153003671 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 312153003672 putative active site [active] 312153003673 putative substrate binding site [chemical binding]; other site 312153003674 putative cosubstrate binding site; other site 312153003675 catalytic site [active] 312153003676 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 312153003677 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 312153003678 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 312153003679 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 312153003680 Cytochrome c; Region: Cytochrom_C; pfam00034 312153003681 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 312153003682 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 312153003683 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 312153003684 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 312153003685 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 312153003686 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 312153003687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153003688 catalytic loop [active] 312153003689 iron binding site [ion binding]; other site 312153003690 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 312153003691 LrgA family; Region: LrgA; pfam03788 312153003692 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 312153003693 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153003694 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 312153003695 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 312153003696 PIF1-like helicase; Region: PIF1; pfam05970 312153003697 AAA domain; Region: AAA_30; pfam13604 312153003698 Helicase; Region: Herpes_Helicase; pfam02689 312153003699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 312153003700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 312153003701 metal binding site [ion binding]; metal-binding site 312153003702 active site 312153003703 I-site; other site 312153003704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 312153003705 Zn2+ binding site [ion binding]; other site 312153003706 Mg2+ binding site [ion binding]; other site 312153003707 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 312153003708 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 312153003709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 312153003710 TPR repeat; Region: TPR_11; pfam13414 312153003711 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 312153003712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003713 binding surface 312153003714 TPR motif; other site 312153003715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003716 binding surface 312153003717 TPR repeat; Region: TPR_11; pfam13414 312153003718 TPR motif; other site 312153003719 Tetratricopeptide repeat; Region: TPR_16; pfam13432 312153003720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153003721 TPR motif; other site 312153003722 binding surface 312153003723 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 312153003724 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 312153003725 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 312153003726 DXD motif; other site 312153003727 PilZ domain; Region: PilZ; pfam07238 312153003728 PilZ domain; Region: PilZ; pfam07238 312153003729 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 312153003730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 312153003731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 312153003732 metal binding site [ion binding]; metal-binding site 312153003733 active site 312153003734 I-site; other site 312153003735 GAF domain; Region: GAF; pfam01590 312153003736 GAF domain; Region: GAF_2; pfam13185 312153003737 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 312153003738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 312153003739 Zn2+ binding site [ion binding]; other site 312153003740 Mg2+ binding site [ion binding]; other site 312153003741 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 312153003742 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 312153003743 FMN binding site [chemical binding]; other site 312153003744 active site 312153003745 catalytic residues [active] 312153003746 substrate binding site [chemical binding]; other site 312153003747 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153003748 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 312153003749 Amidase; Region: Amidase; cl11426 312153003750 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 312153003751 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 312153003752 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 312153003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003754 dimer interface [polypeptide binding]; other site 312153003755 conserved gate region; other site 312153003756 putative PBP binding loops; other site 312153003757 ABC-ATPase subunit interface; other site 312153003758 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 312153003759 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 312153003760 Walker A/P-loop; other site 312153003761 ATP binding site [chemical binding]; other site 312153003762 Q-loop/lid; other site 312153003763 ABC transporter signature motif; other site 312153003764 Walker B; other site 312153003765 D-loop; other site 312153003766 H-loop/switch region; other site 312153003767 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 312153003768 Amidase; Region: Amidase; cl11426 312153003769 indole-3-acetamide amidohydrolase; Region: PLN02722 312153003770 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 312153003771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 312153003772 substrate binding pocket [chemical binding]; other site 312153003773 membrane-bound complex binding site; other site 312153003774 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 312153003775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003776 dimer interface [polypeptide binding]; other site 312153003777 conserved gate region; other site 312153003778 putative PBP binding loops; other site 312153003779 ABC-ATPase subunit interface; other site 312153003780 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 312153003781 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 312153003782 Walker A/P-loop; other site 312153003783 ATP binding site [chemical binding]; other site 312153003784 Q-loop/lid; other site 312153003785 ABC transporter signature motif; other site 312153003786 Walker B; other site 312153003787 D-loop; other site 312153003788 H-loop/switch region; other site 312153003789 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 312153003790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 312153003791 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 312153003792 UreF; Region: UreF; pfam01730 312153003793 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 312153003794 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 312153003795 dimer interface [polypeptide binding]; other site 312153003796 catalytic residues [active] 312153003797 SpaB C-terminal domain; Region: SpaB_C; cl14828 312153003798 urease subunit alpha; Reviewed; Region: ureC; PRK13207 312153003799 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 312153003800 subunit interactions [polypeptide binding]; other site 312153003801 active site 312153003802 flap region; other site 312153003803 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 312153003804 alpha-beta subunit interface [polypeptide binding]; other site 312153003805 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 312153003806 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 312153003807 alpha-gamma subunit interface [polypeptide binding]; other site 312153003808 beta-gamma subunit interface [polypeptide binding]; other site 312153003809 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 312153003810 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 312153003811 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 312153003812 Walker A/P-loop; other site 312153003813 ATP binding site [chemical binding]; other site 312153003814 Q-loop/lid; other site 312153003815 ABC transporter signature motif; other site 312153003816 Walker B; other site 312153003817 D-loop; other site 312153003818 H-loop/switch region; other site 312153003819 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 312153003820 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 312153003821 Walker A/P-loop; other site 312153003822 ATP binding site [chemical binding]; other site 312153003823 Q-loop/lid; other site 312153003824 ABC transporter signature motif; other site 312153003825 Walker B; other site 312153003826 D-loop; other site 312153003827 H-loop/switch region; other site 312153003828 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 312153003829 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 312153003830 TM-ABC transporter signature motif; other site 312153003831 HEAT repeats; Region: HEAT_2; pfam13646 312153003832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 312153003833 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 312153003834 TM-ABC transporter signature motif; other site 312153003835 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 312153003836 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 312153003837 putative ligand binding site [chemical binding]; other site 312153003838 Secretory lipase; Region: LIP; pfam03583 312153003839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 312153003840 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 312153003841 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 312153003842 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 312153003843 active site 312153003844 FMN binding site [chemical binding]; other site 312153003845 substrate binding site [chemical binding]; other site 312153003846 3Fe-4S cluster binding site [ion binding]; other site 312153003847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 312153003848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 312153003849 metal binding site [ion binding]; metal-binding site 312153003850 active site 312153003851 I-site; other site 312153003852 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 312153003853 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 312153003854 active site 312153003855 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 312153003856 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 312153003857 Cupin domain; Region: Cupin_2; cl17218 312153003858 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 312153003859 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 312153003860 putative C-terminal domain interface [polypeptide binding]; other site 312153003861 putative GSH binding site (G-site) [chemical binding]; other site 312153003862 putative dimer interface [polypeptide binding]; other site 312153003863 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 312153003864 putative N-terminal domain interface [polypeptide binding]; other site 312153003865 putative dimer interface [polypeptide binding]; other site 312153003866 putative substrate binding pocket (H-site) [chemical binding]; other site 312153003867 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 312153003868 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 312153003869 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 312153003870 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 312153003871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 312153003872 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 312153003873 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 312153003874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 312153003875 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 312153003876 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 312153003877 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 312153003878 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 312153003879 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 312153003880 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 312153003881 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 312153003882 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 312153003883 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 312153003884 RNA binding site [nucleotide binding]; other site 312153003885 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 312153003886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153003887 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 312153003888 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 312153003889 G1 box; other site 312153003890 putative GEF interaction site [polypeptide binding]; other site 312153003891 GTP/Mg2+ binding site [chemical binding]; other site 312153003892 Switch I region; other site 312153003893 G2 box; other site 312153003894 G3 box; other site 312153003895 Switch II region; other site 312153003896 G4 box; other site 312153003897 G5 box; other site 312153003898 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 312153003899 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 312153003900 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 312153003901 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 312153003902 RNA binding site [nucleotide binding]; other site 312153003903 active site 312153003904 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 312153003905 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 312153003906 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 312153003907 translation initiation factor IF-2; Region: IF-2; TIGR00487 312153003908 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 312153003909 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 312153003910 G1 box; other site 312153003911 putative GEF interaction site [polypeptide binding]; other site 312153003912 GTP/Mg2+ binding site [chemical binding]; other site 312153003913 Switch I region; other site 312153003914 G2 box; other site 312153003915 G3 box; other site 312153003916 Switch II region; other site 312153003917 G4 box; other site 312153003918 G5 box; other site 312153003919 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 312153003920 Translation-initiation factor 2; Region: IF-2; pfam11987 312153003921 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 312153003922 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 312153003923 NusA N-terminal domain; Region: NusA_N; pfam08529 312153003924 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 312153003925 RNA binding site [nucleotide binding]; other site 312153003926 homodimer interface [polypeptide binding]; other site 312153003927 NusA-like KH domain; Region: KH_5; pfam13184 312153003928 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 312153003929 G-X-X-G motif; other site 312153003930 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 312153003931 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 312153003932 ribosome maturation protein RimP; Reviewed; Region: PRK00092 312153003933 Sm and related proteins; Region: Sm_like; cl00259 312153003934 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 312153003935 putative oligomer interface [polypeptide binding]; other site 312153003936 putative RNA binding site [nucleotide binding]; other site 312153003937 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 312153003938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153003939 RNA binding surface [nucleotide binding]; other site 312153003940 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 312153003941 probable active site [active] 312153003942 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 312153003943 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 312153003944 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 312153003945 active site 312153003946 nucleophile elbow; other site 312153003947 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 312153003948 NlpC/P60 family; Region: NLPC_P60; pfam00877 312153003949 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 312153003950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 312153003951 Walker A/P-loop; other site 312153003952 ATP binding site [chemical binding]; other site 312153003953 Q-loop/lid; other site 312153003954 ABC transporter signature motif; other site 312153003955 Walker B; other site 312153003956 D-loop; other site 312153003957 H-loop/switch region; other site 312153003958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 312153003959 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 312153003960 Walker A/P-loop; other site 312153003961 ATP binding site [chemical binding]; other site 312153003962 Q-loop/lid; other site 312153003963 ABC transporter signature motif; other site 312153003964 Walker B; other site 312153003965 D-loop; other site 312153003966 H-loop/switch region; other site 312153003967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 312153003968 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 312153003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003970 dimer interface [polypeptide binding]; other site 312153003971 conserved gate region; other site 312153003972 putative PBP binding loops; other site 312153003973 ABC-ATPase subunit interface; other site 312153003974 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 312153003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153003976 dimer interface [polypeptide binding]; other site 312153003977 conserved gate region; other site 312153003978 putative PBP binding loops; other site 312153003979 ABC-ATPase subunit interface; other site 312153003980 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 312153003981 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 312153003982 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 312153003983 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 312153003984 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 312153003985 NAD binding site [chemical binding]; other site 312153003986 homotetramer interface [polypeptide binding]; other site 312153003987 homodimer interface [polypeptide binding]; other site 312153003988 substrate binding site [chemical binding]; other site 312153003989 active site 312153003990 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 312153003991 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 312153003992 Chromate transporter; Region: Chromate_transp; pfam02417 312153003993 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 312153003994 Helix-turn-helix domain; Region: HTH_38; pfam13936 312153003995 Integrase core domain; Region: rve; pfam00665 312153003996 Uncharacterized conserved protein [Function unknown]; Region: COG3777 312153003997 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 312153003998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 312153003999 active site 2 [active] 312153004000 active site 1 [active] 312153004001 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 312153004002 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 312153004003 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004004 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 312153004005 BNR repeat-like domain; Region: BNR_2; pfam13088 312153004006 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 312153004007 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 312153004008 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 312153004009 Helix-turn-helix domain; Region: HTH_38; pfam13936 312153004010 Winged helix-turn helix; Region: HTH_29; pfam13551 312153004011 Integrase core domain; Region: rve; pfam00665 312153004012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 312153004013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 312153004014 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 312153004015 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 312153004016 putative catalytic site [active] 312153004017 putative phosphate binding site [ion binding]; other site 312153004018 active site 312153004019 metal binding site A [ion binding]; metal-binding site 312153004020 DNA binding site [nucleotide binding] 312153004021 putative AP binding site [nucleotide binding]; other site 312153004022 putative metal binding site B [ion binding]; other site 312153004023 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 312153004024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153004025 active site 312153004026 phosphorylation site [posttranslational modification] 312153004027 intermolecular recognition site; other site 312153004028 dimerization interface [polypeptide binding]; other site 312153004029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153004030 Walker A motif; other site 312153004031 ATP binding site [chemical binding]; other site 312153004032 Walker B motif; other site 312153004033 arginine finger; other site 312153004034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 312153004035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 312153004036 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 312153004037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153004038 dimer interface [polypeptide binding]; other site 312153004039 phosphorylation site [posttranslational modification] 312153004040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153004041 ATP binding site [chemical binding]; other site 312153004042 Mg2+ binding site [ion binding]; other site 312153004043 G-X-G motif; other site 312153004044 glutamine synthetase; Provisional; Region: glnA; PRK09469 312153004045 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 312153004046 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 312153004047 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 312153004048 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 312153004049 putative MPT binding site; other site 312153004050 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 312153004051 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 312153004052 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 312153004053 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 312153004054 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 312153004055 NodB motif; other site 312153004056 active site 312153004057 catalytic site [active] 312153004058 metal binding site [ion binding]; metal-binding site 312153004059 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 312153004060 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 312153004061 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 312153004062 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 312153004063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153004064 ATP binding site [chemical binding]; other site 312153004065 putative Mg++ binding site [ion binding]; other site 312153004066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153004067 nucleotide binding region [chemical binding]; other site 312153004068 ATP-binding site [chemical binding]; other site 312153004069 Helicase associated domain (HA2); Region: HA2; pfam04408 312153004070 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 312153004071 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 312153004072 N-acetylglutamate synthase; Validated; Region: PRK05279 312153004073 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 312153004074 putative feedback inhibition sensing region; other site 312153004075 putative nucleotide binding site [chemical binding]; other site 312153004076 putative substrate binding site [chemical binding]; other site 312153004077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153004078 Coenzyme A binding pocket [chemical binding]; other site 312153004079 oxidative damage protection protein; Provisional; Region: PRK05408 312153004080 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 312153004081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 312153004082 active site 312153004083 dimer interface [polypeptide binding]; other site 312153004084 transaldolase-like protein; Provisional; Region: PTZ00411 312153004085 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 312153004086 active site 312153004087 dimer interface [polypeptide binding]; other site 312153004088 catalytic residue [active] 312153004089 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 312153004090 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 312153004091 active site 312153004092 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 312153004093 Coenzyme A transferase; Region: CoA_trans; smart00882 312153004094 Coenzyme A transferase; Region: CoA_trans; cl17247 312153004095 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 312153004096 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 312153004097 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 312153004098 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 312153004099 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 312153004100 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 312153004101 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 312153004102 RNA binding site [nucleotide binding]; other site 312153004103 RNB domain; Region: RNB; pfam00773 312153004104 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 312153004105 RNA binding site [nucleotide binding]; other site 312153004106 amino acid transporter; Region: 2A0306; TIGR00909 312153004107 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 312153004108 AzlC protein; Region: AzlC; pfam03591 312153004109 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 312153004110 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 312153004111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153004112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153004113 putative substrate translocation pore; other site 312153004114 malate synthase G; Provisional; Region: PRK02999 312153004115 active site 312153004116 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 312153004117 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 312153004118 GDP-binding site [chemical binding]; other site 312153004119 ACT binding site; other site 312153004120 IMP binding site; other site 312153004121 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 312153004122 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 312153004123 dimer interface [polypeptide binding]; other site 312153004124 motif 1; other site 312153004125 active site 312153004126 motif 2; other site 312153004127 motif 3; other site 312153004128 HflC protein; Region: hflC; TIGR01932 312153004129 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 312153004130 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 312153004131 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 312153004132 HflK protein; Region: hflK; TIGR01933 312153004133 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 312153004134 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 312153004135 HflX GTPase family; Region: HflX; cd01878 312153004136 G1 box; other site 312153004137 GTP/Mg2+ binding site [chemical binding]; other site 312153004138 Switch I region; other site 312153004139 G2 box; other site 312153004140 G3 box; other site 312153004141 Switch II region; other site 312153004142 G4 box; other site 312153004143 G5 box; other site 312153004144 bacterial Hfq-like; Region: Hfq; cd01716 312153004145 hexamer interface [polypeptide binding]; other site 312153004146 Sm1 motif; other site 312153004147 RNA binding site [nucleotide binding]; other site 312153004148 Sm2 motif; other site 312153004149 GTP-binding protein Der; Reviewed; Region: PRK00093 312153004150 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 312153004151 G1 box; other site 312153004152 GTP/Mg2+ binding site [chemical binding]; other site 312153004153 Switch I region; other site 312153004154 G2 box; other site 312153004155 Switch II region; other site 312153004156 G3 box; other site 312153004157 G4 box; other site 312153004158 G5 box; other site 312153004159 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 312153004160 G1 box; other site 312153004161 GTP/Mg2+ binding site [chemical binding]; other site 312153004162 Switch I region; other site 312153004163 G2 box; other site 312153004164 G3 box; other site 312153004165 Switch II region; other site 312153004166 G4 box; other site 312153004167 G5 box; other site 312153004168 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 312153004169 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 312153004170 Trp docking motif [polypeptide binding]; other site 312153004171 active site 312153004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 312153004173 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 312153004174 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 312153004175 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 312153004176 dimer interface [polypeptide binding]; other site 312153004177 motif 1; other site 312153004178 active site 312153004179 motif 2; other site 312153004180 motif 3; other site 312153004181 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 312153004182 anticodon binding site; other site 312153004183 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 312153004184 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 312153004185 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 312153004186 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 312153004187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153004188 FeS/SAM binding site; other site 312153004189 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 312153004190 active site 312153004191 multimer interface [polypeptide binding]; other site 312153004192 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 312153004193 YccA-like proteins; Region: YccA_like; cd10433 312153004194 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 312153004195 TRAM domain; Region: TRAM; cl01282 312153004196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153004197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153004198 S-adenosylmethionine binding site [chemical binding]; other site 312153004199 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 312153004200 active site 312153004201 catalytic site [active] 312153004202 substrate binding site [chemical binding]; other site 312153004203 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 312153004204 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 312153004205 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 312153004206 Peptidase family M23; Region: Peptidase_M23; pfam01551 312153004207 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 312153004208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153004209 S-adenosylmethionine binding site [chemical binding]; other site 312153004210 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 312153004211 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 312153004212 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 312153004213 HlyD family secretion protein; Region: HlyD_3; pfam13437 312153004214 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 312153004215 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 312153004216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153004217 TPR motif; other site 312153004218 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 312153004219 Part of AAA domain; Region: AAA_19; pfam13245 312153004220 Family description; Region: UvrD_C_2; pfam13538 312153004221 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 312153004222 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 312153004223 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 312153004224 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 312153004225 catalytic residues [active] 312153004226 transcription termination factor Rho; Provisional; Region: rho; PRK09376 312153004227 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 312153004228 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 312153004229 RNA binding site [nucleotide binding]; other site 312153004230 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 312153004231 multimer interface [polypeptide binding]; other site 312153004232 Walker A motif; other site 312153004233 ATP binding site [chemical binding]; other site 312153004234 Walker B motif; other site 312153004235 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 312153004236 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 312153004237 multidrug efflux protein; Reviewed; Region: PRK01766 312153004238 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 312153004239 cation binding site [ion binding]; other site 312153004240 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 312153004241 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 312153004242 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 312153004243 putative dimer interface [polypeptide binding]; other site 312153004244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 312153004245 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004246 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 312153004247 enoyl-CoA hydratase; Provisional; Region: PRK06144 312153004248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 312153004249 substrate binding site [chemical binding]; other site 312153004250 oxyanion hole (OAH) forming residues; other site 312153004251 trimer interface [polypeptide binding]; other site 312153004252 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 312153004253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 312153004254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 312153004255 catalytic residue [active] 312153004256 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 312153004257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 312153004258 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 312153004259 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 312153004260 Uncharacterized conserved protein [Function unknown]; Region: COG4095 312153004261 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004262 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 312153004263 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 312153004264 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 312153004265 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004266 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 312153004267 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 312153004268 active site 312153004269 intersubunit interface [polypeptide binding]; other site 312153004270 Zn2+ binding site [ion binding]; other site 312153004271 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 312153004272 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 312153004273 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 312153004274 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 312153004275 G1 box; other site 312153004276 GTP/Mg2+ binding site [chemical binding]; other site 312153004277 Switch I region; other site 312153004278 G2 box; other site 312153004279 G3 box; other site 312153004280 Switch II region; other site 312153004281 G4 box; other site 312153004282 G5 box; other site 312153004283 Nucleoside recognition; Region: Gate; pfam07670 312153004284 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 312153004285 Nucleoside recognition; Region: Gate; pfam07670 312153004286 FeoA domain; Region: FeoA; pfam04023 312153004287 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 312153004288 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 312153004289 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 312153004290 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 312153004291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153004292 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 312153004293 PBP superfamily domain; Region: PBP_like; pfam12727 312153004294 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 312153004295 PBP superfamily domain; Region: PBP_like_2; pfam12849 312153004296 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 312153004297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 312153004298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153004299 Coenzyme A binding pocket [chemical binding]; other site 312153004300 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 312153004301 active site 312153004302 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 312153004303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 312153004304 DEAD-like helicases superfamily; Region: DEXDc; smart00487 312153004305 ATP binding site [chemical binding]; other site 312153004306 Mg++ binding site [ion binding]; other site 312153004307 motif III; other site 312153004308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153004309 nucleotide binding region [chemical binding]; other site 312153004310 ATP-binding site [chemical binding]; other site 312153004311 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 312153004312 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 312153004313 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 312153004314 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 312153004315 catalytic residues [active] 312153004316 selenophosphate synthetase; Provisional; Region: PRK00943 312153004317 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 312153004318 dimerization interface [polypeptide binding]; other site 312153004319 putative ATP binding site [chemical binding]; other site 312153004320 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 312153004321 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004322 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153004323 active site residue [active] 312153004324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 312153004325 active site residue [active] 312153004326 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 312153004327 active site residue [active] 312153004328 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 312153004329 active site residue [active] 312153004330 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 312153004331 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 312153004332 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 312153004333 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 312153004334 apolar tunnel; other site 312153004335 heme binding site [chemical binding]; other site 312153004336 dimerization interface [polypeptide binding]; other site 312153004337 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 312153004338 Predicted flavoproteins [General function prediction only]; Region: COG2081 312153004339 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 312153004340 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 312153004341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 312153004342 substrate binding pocket [chemical binding]; other site 312153004343 membrane-bound complex binding site; other site 312153004344 hinge residues; other site 312153004345 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 312153004346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 312153004347 Beta-Casp domain; Region: Beta-Casp; smart01027 312153004348 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 312153004349 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 312153004350 putative substrate binding site [chemical binding]; other site 312153004351 putative ATP binding site [chemical binding]; other site 312153004352 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 312153004353 EamA-like transporter family; Region: EamA; pfam00892 312153004354 EamA-like transporter family; Region: EamA; pfam00892 312153004355 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 312153004356 heme-binding site [chemical binding]; other site 312153004357 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 312153004358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 312153004359 catalytic residue [active] 312153004360 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004361 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 312153004362 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 312153004363 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 312153004364 EamA-like transporter family; Region: EamA; pfam00892 312153004365 EamA-like transporter family; Region: EamA; pfam00892 312153004366 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 312153004367 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 312153004368 phosphate binding site [ion binding]; other site 312153004369 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 312153004370 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 312153004371 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 312153004372 FMN binding site [chemical binding]; other site 312153004373 active site 312153004374 substrate binding site [chemical binding]; other site 312153004375 catalytic residue [active] 312153004376 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 312153004377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153004378 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 312153004379 dimerization interface [polypeptide binding]; other site 312153004380 Rubrerythrin [Energy production and conversion]; Region: COG1592 312153004381 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 312153004382 binuclear metal center [ion binding]; other site 312153004383 Rubredoxin [Energy production and conversion]; Region: COG1773 312153004384 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 312153004385 iron binding site [ion binding]; other site 312153004386 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 312153004387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153004388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153004389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153004390 binding surface 312153004391 TPR repeat; Region: TPR_11; pfam13414 312153004392 TPR motif; other site 312153004393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 312153004394 binding surface 312153004395 TPR motif; other site 312153004396 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 312153004397 Thioredoxin; Region: Thioredoxin_4; cl17273 312153004398 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 312153004399 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 312153004400 Protein of unknown function (DUF989); Region: DUF989; pfam06181 312153004401 superoxide dismutase; Provisional; Region: PRK10543 312153004402 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 312153004403 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 312153004404 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 312153004405 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 312153004406 NAD binding site [chemical binding]; other site 312153004407 homotetramer interface [polypeptide binding]; other site 312153004408 homodimer interface [polypeptide binding]; other site 312153004409 substrate binding site [chemical binding]; other site 312153004410 active site 312153004411 Predicted membrane protein [Function unknown]; Region: COG1238 312153004412 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 312153004413 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 312153004414 active site 312153004415 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 312153004416 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153004417 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 312153004418 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 312153004419 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 312153004420 putative active site [active] 312153004421 catalytic site [active] 312153004422 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 312153004423 putative active site [active] 312153004424 catalytic site [active] 312153004425 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 312153004426 putative catalytic site [active] 312153004427 putative metal binding site [ion binding]; other site 312153004428 putative phosphate binding site [ion binding]; other site 312153004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153004430 dimer interface [polypeptide binding]; other site 312153004431 conserved gate region; other site 312153004432 putative PBP binding loops; other site 312153004433 ABC-ATPase subunit interface; other site 312153004434 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 312153004435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153004436 Walker A/P-loop; other site 312153004437 ATP binding site [chemical binding]; other site 312153004438 Q-loop/lid; other site 312153004439 ABC transporter signature motif; other site 312153004440 Walker B; other site 312153004441 D-loop; other site 312153004442 H-loop/switch region; other site 312153004443 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 312153004444 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 312153004445 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 312153004446 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 312153004447 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 312153004448 [4Fe-4S] binding site [ion binding]; other site 312153004449 molybdopterin cofactor binding site; other site 312153004450 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 312153004451 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 312153004452 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 312153004453 molybdopterin cofactor binding site; other site 312153004454 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 312153004455 4Fe-4S binding domain; Region: Fer4; pfam00037 312153004456 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 312153004457 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 312153004458 4Fe-4S binding domain; Region: Fer4; pfam00037 312153004459 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 312153004460 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 312153004461 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 312153004462 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 312153004463 antiporter inner membrane protein; Provisional; Region: PRK11670 312153004464 Domain of unknown function DUF59; Region: DUF59; pfam01883 312153004465 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 312153004466 Walker A motif; other site 312153004467 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 312153004468 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 312153004469 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 312153004470 metal-binding site [ion binding] 312153004471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 312153004472 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 312153004473 metal-binding site [ion binding] 312153004474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 312153004475 Soluble P-type ATPase [General function prediction only]; Region: COG4087 312153004476 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 312153004477 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 312153004478 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 312153004479 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 312153004480 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153004481 putative active site [active] 312153004482 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 312153004483 active site 312153004484 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 312153004485 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 312153004486 SOUL heme-binding protein; Region: SOUL; pfam04832 312153004487 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 312153004488 dimer interface [polypeptide binding]; other site 312153004489 catalytic triad [active] 312153004490 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 312153004491 nucleoside/Zn binding site; other site 312153004492 dimer interface [polypeptide binding]; other site 312153004493 catalytic motif [active] 312153004494 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 312153004495 active site 312153004496 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 312153004497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153004498 FeS/SAM binding site; other site 312153004499 B12 binding domain; Region: B12-binding; pfam02310 312153004500 B12 binding site [chemical binding]; other site 312153004501 Radical SAM superfamily; Region: Radical_SAM; pfam04055 312153004502 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 312153004503 dinuclear metal binding motif [ion binding]; other site 312153004504 GMP synthase; Reviewed; Region: guaA; PRK00074 312153004505 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 312153004506 AMP/PPi binding site [chemical binding]; other site 312153004507 candidate oxyanion hole; other site 312153004508 catalytic triad [active] 312153004509 potential glutamine specificity residues [chemical binding]; other site 312153004510 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 312153004511 ATP Binding subdomain [chemical binding]; other site 312153004512 Ligand Binding sites [chemical binding]; other site 312153004513 Dimerization subdomain; other site 312153004514 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 312153004515 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 312153004516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 312153004517 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 312153004518 active site 312153004519 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 312153004520 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 312153004521 putative coenzyme Q binding site [chemical binding]; other site 312153004522 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 312153004523 SmpB-tmRNA interface; other site 312153004524 Uncharacterized conserved protein [Function unknown]; Region: COG2308 312153004525 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 312153004526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 312153004527 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 312153004528 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 312153004529 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 312153004530 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 312153004531 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 312153004532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 312153004533 Helix-turn-helix domain; Region: HTH_28; pfam13518 312153004534 Helix-turn-helix domain; Region: HTH_28; pfam13518 312153004535 Homeodomain-like domain; Region: HTH_32; pfam13565 312153004536 putative transposase OrfB; Reviewed; Region: PHA02517 312153004537 HTH-like domain; Region: HTH_21; pfam13276 312153004538 Integrase core domain; Region: rve; pfam00665 312153004539 Integrase core domain; Region: rve_2; pfam13333 312153004540 phosphoenolpyruvate synthase; Validated; Region: PRK06464 312153004541 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 312153004542 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 312153004543 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 312153004544 PEP synthetase regulatory protein; Provisional; Region: PRK05339 312153004545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 312153004546 Secretory lipase; Region: LIP; pfam03583 312153004547 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 312153004548 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 312153004549 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 312153004550 RNA/DNA hybrid binding site [nucleotide binding]; other site 312153004551 active site 312153004552 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 312153004553 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 312153004554 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 312153004555 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 312153004556 active site 312153004557 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 312153004558 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 312153004559 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 312153004560 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 312153004561 trimer interface [polypeptide binding]; other site 312153004562 active site 312153004563 UDP-GlcNAc binding site [chemical binding]; other site 312153004564 lipid binding site [chemical binding]; lipid-binding site 312153004565 periplasmic chaperone; Provisional; Region: PRK10780 312153004566 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 312153004567 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 312153004568 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 312153004569 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 312153004570 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 312153004571 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 312153004572 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 312153004573 Surface antigen; Region: Bac_surface_Ag; pfam01103 312153004574 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 312153004575 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 312153004576 active site 312153004577 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 312153004578 putative substrate binding region [chemical binding]; other site 312153004579 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 312153004580 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 312153004581 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 312153004582 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 312153004583 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 312153004584 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 312153004585 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 312153004586 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 312153004587 catalytic residue [active] 312153004588 putative FPP diphosphate binding site; other site 312153004589 putative FPP binding hydrophobic cleft; other site 312153004590 dimer interface [polypeptide binding]; other site 312153004591 putative IPP diphosphate binding site; other site 312153004592 ribosome recycling factor; Reviewed; Region: frr; PRK00083 312153004593 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 312153004594 hinge region; other site 312153004595 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 312153004596 putative nucleotide binding site [chemical binding]; other site 312153004597 uridine monophosphate binding site [chemical binding]; other site 312153004598 homohexameric interface [polypeptide binding]; other site 312153004599 elongation factor Ts; Provisional; Region: tsf; PRK09377 312153004600 UBA/TS-N domain; Region: UBA; pfam00627 312153004601 Elongation factor TS; Region: EF_TS; pfam00889 312153004602 Elongation factor TS; Region: EF_TS; pfam00889 312153004603 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 312153004604 rRNA interaction site [nucleotide binding]; other site 312153004605 S8 interaction site; other site 312153004606 putative laminin-1 binding site; other site 312153004607 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 312153004608 active site 312153004609 PII uridylyl-transferase; Provisional; Region: PRK03059 312153004610 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 312153004611 metal binding triad; other site 312153004612 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 312153004613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 312153004614 Zn2+ binding site [ion binding]; other site 312153004615 Mg2+ binding site [ion binding]; other site 312153004616 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 312153004617 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 312153004618 Predicted membrane protein [Function unknown]; Region: COG2259 312153004619 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 312153004620 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 312153004621 nucleotide binding pocket [chemical binding]; other site 312153004622 K-X-D-G motif; other site 312153004623 catalytic site [active] 312153004624 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 312153004625 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 312153004626 Helix-hairpin-helix motif; Region: HHH; pfam00633 312153004627 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 312153004628 Dimer interface [polypeptide binding]; other site 312153004629 BRCT sequence motif; other site 312153004630 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 312153004631 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 312153004632 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 312153004633 Walker A/P-loop; other site 312153004634 ATP binding site [chemical binding]; other site 312153004635 Q-loop/lid; other site 312153004636 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 312153004637 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 312153004638 ABC transporter signature motif; other site 312153004639 Walker B; other site 312153004640 D-loop; other site 312153004641 H-loop/switch region; other site 312153004642 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 312153004643 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 312153004644 trimer interface [polypeptide binding]; other site 312153004645 active site 312153004646 substrate binding site [chemical binding]; other site 312153004647 CoA binding site [chemical binding]; other site 312153004648 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 312153004649 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 312153004650 metal binding site [ion binding]; metal-binding site 312153004651 dimer interface [polypeptide binding]; other site 312153004652 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 312153004653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153004654 S-adenosylmethionine binding site [chemical binding]; other site 312153004655 DNA repair protein RadA; Provisional; Region: PRK11823 312153004656 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 312153004657 Walker A motif/ATP binding site; other site 312153004658 ATP binding site [chemical binding]; other site 312153004659 Walker B motif; other site 312153004660 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 312153004661 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 312153004662 potassium uptake protein; Region: kup; TIGR00794 312153004663 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 312153004664 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 312153004665 Competence protein; Region: Competence; pfam03772 312153004666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 312153004667 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 312153004668 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 312153004669 active site 312153004670 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 312153004671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 312153004672 Walker A/P-loop; other site 312153004673 ATP binding site [chemical binding]; other site 312153004674 Q-loop/lid; other site 312153004675 ABC transporter signature motif; other site 312153004676 Walker B; other site 312153004677 D-loop; other site 312153004678 H-loop/switch region; other site 312153004679 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 312153004680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 312153004681 FtsX-like permease family; Region: FtsX; pfam02687 312153004682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 312153004683 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 312153004684 DHH family; Region: DHH; pfam01368 312153004685 DHHA1 domain; Region: DHHA1; pfam02272 312153004686 peptide chain release factor 2; Validated; Region: prfB; PRK00578 312153004687 This domain is found in peptide chain release factors; Region: PCRF; smart00937 312153004688 RF-1 domain; Region: RF-1; pfam00472 312153004689 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 312153004690 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 312153004691 dimer interface [polypeptide binding]; other site 312153004692 putative anticodon binding site; other site 312153004693 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 312153004694 motif 1; other site 312153004695 active site 312153004696 motif 2; other site 312153004697 motif 3; other site 312153004698 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 312153004699 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 312153004700 ligand binding site [chemical binding]; other site 312153004701 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 312153004702 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 312153004703 dimer interface [polypeptide binding]; other site 312153004704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153004705 catalytic residue [active] 312153004706 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 312153004707 active site 312153004708 catalytic residues [active] 312153004709 metal binding site [ion binding]; metal-binding site 312153004710 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 312153004711 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 312153004712 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 312153004713 FAD binding pocket [chemical binding]; other site 312153004714 FAD binding motif [chemical binding]; other site 312153004715 phosphate binding motif [ion binding]; other site 312153004716 beta-alpha-beta structure motif; other site 312153004717 NAD binding pocket [chemical binding]; other site 312153004718 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 312153004719 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 312153004720 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 312153004721 Active Sites [active] 312153004722 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 312153004723 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 312153004724 Active Sites [active] 312153004725 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 312153004726 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 312153004727 CysD dimerization site [polypeptide binding]; other site 312153004728 G1 box; other site 312153004729 putative GEF interaction site [polypeptide binding]; other site 312153004730 GTP/Mg2+ binding site [chemical binding]; other site 312153004731 Switch I region; other site 312153004732 G2 box; other site 312153004733 G3 box; other site 312153004734 Switch II region; other site 312153004735 G4 box; other site 312153004736 G5 box; other site 312153004737 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 312153004738 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 312153004739 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 312153004740 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 312153004741 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 312153004742 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 312153004743 Moco binding site; other site 312153004744 metal coordination site [ion binding]; other site 312153004745 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 312153004746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153004747 catalytic loop [active] 312153004748 iron binding site [ion binding]; other site 312153004749 chaperone protein HscA; Provisional; Region: hscA; PRK05183 312153004750 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 312153004751 nucleotide binding site [chemical binding]; other site 312153004752 putative NEF/HSP70 interaction site [polypeptide binding]; other site 312153004753 SBD interface [polypeptide binding]; other site 312153004754 co-chaperone HscB; Provisional; Region: hscB; PRK03578 312153004755 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 312153004756 HSP70 interaction site [polypeptide binding]; other site 312153004757 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 312153004758 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 312153004759 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 312153004760 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 312153004761 trimerization site [polypeptide binding]; other site 312153004762 active site 312153004763 cysteine desulfurase; Provisional; Region: PRK14012 312153004764 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 312153004765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 312153004766 catalytic residue [active] 312153004767 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 312153004768 Rrf2 family protein; Region: rrf2_super; TIGR00738 312153004769 excinuclease ABC subunit B; Provisional; Region: PRK05298 312153004770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153004771 ATP binding site [chemical binding]; other site 312153004772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153004773 nucleotide binding region [chemical binding]; other site 312153004774 ATP-binding site [chemical binding]; other site 312153004775 Ultra-violet resistance protein B; Region: UvrB; pfam12344 312153004776 UvrB/uvrC motif; Region: UVR; pfam02151 312153004777 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 312153004778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153004779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153004780 homodimer interface [polypeptide binding]; other site 312153004781 catalytic residue [active] 312153004782 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 312153004783 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 312153004784 ferredoxin; Provisional; Region: PRK08764 312153004785 Putative Fe-S cluster; Region: FeS; cl17515 312153004786 4Fe-4S binding domain; Region: Fer4; pfam00037 312153004787 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 312153004788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 312153004789 minor groove reading motif; other site 312153004790 helix-hairpin-helix signature motif; other site 312153004791 substrate binding pocket [chemical binding]; other site 312153004792 active site 312153004793 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 312153004794 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 312153004795 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 312153004796 DUF35 OB-fold domain; Region: DUF35; pfam01796 312153004797 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 312153004798 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 312153004799 active site 312153004800 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 312153004801 Coenzyme A transferase; Region: CoA_trans; cl17247 312153004802 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 312153004803 nucleotide binding site/active site [active] 312153004804 HIT family signature motif; other site 312153004805 catalytic residue [active] 312153004806 isocitrate lyase; Provisional; Region: PRK15063 312153004807 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 312153004808 tetramer interface [polypeptide binding]; other site 312153004809 active site 312153004810 Mg2+/Mn2+ binding site [ion binding]; other site 312153004811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153004812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153004813 putative substrate translocation pore; other site 312153004814 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153004815 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 312153004816 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 312153004817 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 312153004818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153004819 binding surface 312153004820 TPR motif; other site 312153004821 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 312153004822 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 312153004823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 312153004824 catalytic residues [active] 312153004825 central insert; other site 312153004826 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 312153004827 CcmE; Region: CcmE; pfam03100 312153004828 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 312153004829 heme exporter protein CcmC; Region: ccmC; TIGR01191 312153004830 heme exporter protein CcmB; Region: ccmB; TIGR01190 312153004831 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 312153004832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153004833 Walker A/P-loop; other site 312153004834 ATP binding site [chemical binding]; other site 312153004835 Q-loop/lid; other site 312153004836 ABC transporter signature motif; other site 312153004837 Walker B; other site 312153004838 D-loop; other site 312153004839 H-loop/switch region; other site 312153004840 Uncharacterized conserved protein [Function unknown]; Region: COG2353 312153004841 YceI-like domain; Region: YceI; smart00867 312153004842 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 312153004843 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 312153004844 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 312153004845 MarR family; Region: MarR_2; cl17246 312153004846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 312153004847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 312153004848 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 312153004849 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 312153004850 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 312153004851 NADP binding site [chemical binding]; other site 312153004852 dimer interface [polypeptide binding]; other site 312153004853 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 312153004854 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 312153004855 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 312153004856 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 312153004857 putative active site [active] 312153004858 Zn binding site [ion binding]; other site 312153004859 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 312153004860 peroxiredoxin; Region: AhpC; TIGR03137 312153004861 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 312153004862 dimer interface [polypeptide binding]; other site 312153004863 decamer (pentamer of dimers) interface [polypeptide binding]; other site 312153004864 catalytic triad [active] 312153004865 peroxidatic and resolving cysteines [active] 312153004866 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 312153004867 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 312153004868 catalytic residue [active] 312153004869 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 312153004870 catalytic residues [active] 312153004871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153004872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 312153004873 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 312153004874 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 312153004875 DctM-like transporters; Region: DctM; pfam06808 312153004876 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 312153004877 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 312153004878 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 312153004879 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 312153004880 classical (c) SDRs; Region: SDR_c; cd05233 312153004881 NAD(P) binding site [chemical binding]; other site 312153004882 active site 312153004883 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 312153004884 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 312153004885 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 312153004886 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 312153004887 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 312153004888 FMN-binding pocket [chemical binding]; other site 312153004889 flavin binding motif; other site 312153004890 phosphate binding motif [ion binding]; other site 312153004891 beta-alpha-beta structure motif; other site 312153004892 NAD binding pocket [chemical binding]; other site 312153004893 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153004894 catalytic loop [active] 312153004895 iron binding site [ion binding]; other site 312153004896 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 312153004897 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 312153004898 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 312153004899 hydrophobic ligand binding site; other site 312153004900 Transcriptional regulators [Transcription]; Region: GntR; COG1802 312153004901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 312153004902 DNA-binding site [nucleotide binding]; DNA binding site 312153004903 FCD domain; Region: FCD; pfam07729 312153004904 hypothetical protein; Provisional; Region: PRK06208 312153004905 intersubunit interface [polypeptide binding]; other site 312153004906 active site 312153004907 Zn2+ binding site [ion binding]; other site 312153004908 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 312153004909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153004910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 312153004911 dimerization interface [polypeptide binding]; other site 312153004912 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 312153004913 EamA-like transporter family; Region: EamA; pfam00892 312153004914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 312153004915 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 312153004916 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 312153004917 putative ligand binding site [chemical binding]; other site 312153004918 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 312153004919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 312153004920 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 312153004921 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 312153004922 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 312153004923 dimer interface [polypeptide binding]; other site 312153004924 TPP-binding site [chemical binding]; other site 312153004925 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 312153004926 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 312153004927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 312153004928 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 312153004929 E3 interaction surface; other site 312153004930 lipoyl attachment site [posttranslational modification]; other site 312153004931 e3 binding domain; Region: E3_binding; pfam02817 312153004932 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 312153004933 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 312153004934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 312153004935 putative DNA binding site [nucleotide binding]; other site 312153004936 putative Zn2+ binding site [ion binding]; other site 312153004937 AsnC family; Region: AsnC_trans_reg; pfam01037 312153004938 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 312153004939 classical (c) SDRs; Region: SDR_c; cd05233 312153004940 NAD(P) binding site [chemical binding]; other site 312153004941 active site 312153004942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 312153004943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 312153004944 active site 312153004945 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 312153004946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 312153004947 substrate binding site [chemical binding]; other site 312153004948 oxyanion hole (OAH) forming residues; other site 312153004949 trimer interface [polypeptide binding]; other site 312153004950 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 312153004951 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 312153004952 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 312153004953 enoyl-CoA hydratase; Provisional; Region: PRK05862 312153004954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 312153004955 substrate binding site [chemical binding]; other site 312153004956 oxyanion hole (OAH) forming residues; other site 312153004957 trimer interface [polypeptide binding]; other site 312153004958 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 312153004959 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 312153004960 tetrameric interface [polypeptide binding]; other site 312153004961 NAD binding site [chemical binding]; other site 312153004962 catalytic residues [active] 312153004963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 312153004964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153004965 LysR substrate binding domain; Region: LysR_substrate; pfam03466 312153004966 dimerization interface [polypeptide binding]; other site 312153004967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153004968 putative substrate translocation pore; other site 312153004969 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 312153004970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 312153004971 acyl-activating enzyme (AAE) consensus motif; other site 312153004972 AMP binding site [chemical binding]; other site 312153004973 active site 312153004974 CoA binding site [chemical binding]; other site 312153004975 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 312153004976 FMN-binding domain; Region: FMN_bind; pfam04205 312153004977 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 312153004978 ApbE family; Region: ApbE; pfam02424 312153004979 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 312153004980 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 312153004981 Protein of unknown function (DUF330); Region: DUF330; pfam03886 312153004982 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 312153004983 mce related protein; Region: MCE; pfam02470 312153004984 mce related protein; Region: MCE; pfam02470 312153004985 mce related protein; Region: MCE; pfam02470 312153004986 Paraquat-inducible protein A; Region: PqiA; pfam04403 312153004987 Paraquat-inducible protein A; Region: PqiA; pfam04403 312153004988 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 312153004989 Transcriptional activator [Transcription]; Region: ChrR; COG3806 312153004990 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 312153004991 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 312153004992 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 312153004993 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 312153004994 active site 312153004995 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 312153004996 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 312153004997 arsenical-resistance protein; Region: acr3; TIGR00832 312153004998 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 312153004999 Low molecular weight phosphatase family; Region: LMWPc; cl00105 312153005000 active site 312153005001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 312153005002 dimerization interface [polypeptide binding]; other site 312153005003 putative DNA binding site [nucleotide binding]; other site 312153005004 putative Zn2+ binding site [ion binding]; other site 312153005005 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 312153005006 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 312153005007 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 312153005008 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 312153005009 putative acyl-acceptor binding pocket; other site 312153005010 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 312153005011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 312153005012 putative active site [active] 312153005013 putative metal binding site [ion binding]; other site 312153005014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 312153005015 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 312153005016 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 312153005017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 312153005018 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 312153005019 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 312153005020 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 312153005021 MgtC family; Region: MgtC; pfam02308 312153005022 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 312153005023 dimer interface [polypeptide binding]; other site 312153005024 Alkaline phosphatase homologues; Region: alkPPc; smart00098 312153005025 active site 312153005026 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 312153005027 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 312153005028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 312153005029 Low molecular weight phosphatase family; Region: LMWPc; cl00105 312153005030 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 312153005031 active site 312153005032 MgtC family; Region: MgtC; pfam02308 312153005033 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 312153005034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153005035 dimer interface [polypeptide binding]; other site 312153005036 phosphorylation site [posttranslational modification] 312153005037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153005038 ATP binding site [chemical binding]; other site 312153005039 Mg2+ binding site [ion binding]; other site 312153005040 G-X-G motif; other site 312153005041 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 312153005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153005043 active site 312153005044 phosphorylation site [posttranslational modification] 312153005045 intermolecular recognition site; other site 312153005046 dimerization interface [polypeptide binding]; other site 312153005047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 312153005048 DNA binding site [nucleotide binding] 312153005049 transcriptional regulator PhoU; Provisional; Region: PRK11115 312153005050 PhoU domain; Region: PhoU; pfam01895 312153005051 PhoU domain; Region: PhoU; pfam01895 312153005052 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 312153005053 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 312153005054 Walker A/P-loop; other site 312153005055 ATP binding site [chemical binding]; other site 312153005056 Q-loop/lid; other site 312153005057 ABC transporter signature motif; other site 312153005058 Walker B; other site 312153005059 D-loop; other site 312153005060 H-loop/switch region; other site 312153005061 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 312153005062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153005063 dimer interface [polypeptide binding]; other site 312153005064 conserved gate region; other site 312153005065 putative PBP binding loops; other site 312153005066 ABC-ATPase subunit interface; other site 312153005067 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 312153005068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 312153005069 dimer interface [polypeptide binding]; other site 312153005070 conserved gate region; other site 312153005071 putative PBP binding loops; other site 312153005072 ABC-ATPase subunit interface; other site 312153005073 PBP superfamily domain; Region: PBP_like_2; cl17296 312153005074 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 312153005075 Protein of unknown function, DUF393; Region: DUF393; pfam04134 312153005076 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 312153005077 C factor cell-cell signaling protein; Provisional; Region: PRK09009 312153005078 NADP binding site [chemical binding]; other site 312153005079 homodimer interface [polypeptide binding]; other site 312153005080 active site 312153005081 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 312153005082 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 312153005083 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 312153005084 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 312153005085 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 312153005086 active site 312153005087 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 312153005088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 312153005089 substrate binding site [chemical binding]; other site 312153005090 oxyanion hole (OAH) forming residues; other site 312153005091 trimer interface [polypeptide binding]; other site 312153005092 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 312153005093 CoA-transferase family III; Region: CoA_transf_3; pfam02515 312153005094 Uncharacterized conserved protein [Function unknown]; Region: COG2966 312153005095 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 312153005096 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 312153005097 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 312153005098 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 312153005099 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 312153005100 malate:quinone oxidoreductase; Validated; Region: PRK05257 312153005101 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 312153005102 Cupin domain; Region: Cupin_2; cl17218 312153005103 fumarate hydratase; Reviewed; Region: fumC; PRK00485 312153005104 Class II fumarases; Region: Fumarase_classII; cd01362 312153005105 active site 312153005106 tetramer interface [polypeptide binding]; other site 312153005107 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 312153005108 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 312153005109 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 312153005110 oligomer interface [polypeptide binding]; other site 312153005111 Predicted amidohydrolase [General function prediction only]; Region: COG0388 312153005112 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 312153005113 active site 312153005114 catalytic triad [active] 312153005115 dimer interface [polypeptide binding]; other site 312153005116 Predicted amidohydrolase [General function prediction only]; Region: COG0388 312153005117 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 312153005118 active site 312153005119 catalytic triad [active] 312153005120 dimer interface [polypeptide binding]; other site 312153005121 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 312153005122 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 312153005123 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 312153005124 E-class dimer interface [polypeptide binding]; other site 312153005125 P-class dimer interface [polypeptide binding]; other site 312153005126 active site 312153005127 Cu2+ binding site [ion binding]; other site 312153005128 Zn2+ binding site [ion binding]; other site 312153005129 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 312153005130 catalytic core [active] 312153005131 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 312153005132 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 312153005133 substrate binding site [chemical binding]; other site 312153005134 intracellular protease, PfpI family; Region: PfpI; TIGR01382 312153005135 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 312153005136 conserved cys residue [active] 312153005137 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 312153005138 putative aldolase; Validated; Region: PRK08130 312153005139 intersubunit interface [polypeptide binding]; other site 312153005140 active site 312153005141 Zn2+ binding site [ion binding]; other site 312153005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 312153005143 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 312153005144 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 312153005145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153005146 D-galactonate transporter; Region: 2A0114; TIGR00893 312153005147 putative substrate translocation pore; other site 312153005148 Transcriptional regulators [Transcription]; Region: FadR; COG2186 312153005149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 312153005150 DNA-binding site [nucleotide binding]; DNA binding site 312153005151 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 312153005152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 312153005153 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 312153005154 putative NAD(P) binding site [chemical binding]; other site 312153005155 active site 312153005156 putative substrate binding site [chemical binding]; other site 312153005157 EamA-like transporter family; Region: EamA; pfam00892 312153005158 EamA-like transporter family; Region: EamA; pfam00892 312153005159 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 312153005160 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 312153005161 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 312153005162 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 312153005163 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 312153005164 catalytic residues [active] 312153005165 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 312153005166 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 312153005167 putative active site [active] 312153005168 metal binding site [ion binding]; metal-binding site 312153005169 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 312153005170 active site 312153005171 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 312153005172 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 312153005173 dimer interface [polypeptide binding]; other site 312153005174 FMN binding site [chemical binding]; other site 312153005175 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 312153005176 active site 312153005177 catalytic site [active] 312153005178 substrate binding site [chemical binding]; other site 312153005179 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 312153005180 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 312153005181 GIY-YIG motif/motif A; other site 312153005182 active site 312153005183 catalytic site [active] 312153005184 putative DNA binding site [nucleotide binding]; other site 312153005185 metal binding site [ion binding]; metal-binding site 312153005186 Rrf2 family protein; Region: rrf2_super; TIGR00738 312153005187 Transcriptional regulator; Region: Rrf2; pfam02082 312153005188 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 312153005189 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 312153005190 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 312153005191 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 312153005192 MAPEG family; Region: MAPEG; pfam01124 312153005193 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 312153005194 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 312153005195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 312153005196 Dihydroneopterin aldolase; Region: FolB; pfam02152 312153005197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 312153005198 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 312153005199 Walker A/P-loop; other site 312153005200 ATP binding site [chemical binding]; other site 312153005201 Q-loop/lid; other site 312153005202 ABC transporter signature motif; other site 312153005203 Walker B; other site 312153005204 D-loop; other site 312153005205 H-loop/switch region; other site 312153005206 ABC-2 type transporter; Region: ABC2_membrane; cl17235 312153005207 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 312153005208 Domain of unknown function (DUF427); Region: DUF427; pfam04248 312153005209 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 312153005210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153005211 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 312153005212 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 312153005213 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 312153005214 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 312153005215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 312153005216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153005217 homodimer interface [polypeptide binding]; other site 312153005218 catalytic residue [active] 312153005219 citrate-proton symporter; Provisional; Region: PRK15075 312153005220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153005221 putative substrate translocation pore; other site 312153005222 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 312153005223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153005224 Coenzyme A binding pocket [chemical binding]; other site 312153005225 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 312153005226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153005227 putative substrate translocation pore; other site 312153005228 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 312153005229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153005230 active site 312153005231 phosphorylation site [posttranslational modification] 312153005232 intermolecular recognition site; other site 312153005233 dimerization interface [polypeptide binding]; other site 312153005234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 312153005235 DNA binding site [nucleotide binding] 312153005236 sensor protein KdpD; Provisional; Region: PRK10490 312153005237 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 312153005238 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 312153005239 Ligand Binding Site [chemical binding]; other site 312153005240 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 312153005241 GAF domain; Region: GAF_3; pfam13492 312153005242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153005243 dimer interface [polypeptide binding]; other site 312153005244 phosphorylation site [posttranslational modification] 312153005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153005246 ATP binding site [chemical binding]; other site 312153005247 Mg2+ binding site [ion binding]; other site 312153005248 G-X-G motif; other site 312153005249 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 312153005250 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 312153005251 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 312153005252 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 312153005253 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 312153005254 metal-binding site [ion binding] 312153005255 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 312153005256 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 312153005257 Heavy-metal-associated domain; Region: HMA; pfam00403 312153005258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 312153005259 Soluble P-type ATPase [General function prediction only]; Region: COG4087 312153005260 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 312153005261 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 312153005262 DNA binding residues [nucleotide binding] 312153005263 dimer interface [polypeptide binding]; other site 312153005264 putative metal binding site [ion binding]; other site 312153005265 Outer membrane efflux protein; Region: OEP; pfam02321 312153005266 Outer membrane efflux protein; Region: OEP; pfam02321 312153005267 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 312153005268 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 312153005269 HlyD family secretion protein; Region: HlyD_3; pfam13437 312153005270 AAA domain; Region: AAA_22; pfam13401 312153005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153005272 Walker A motif; other site 312153005273 ATP binding site [chemical binding]; other site 312153005274 Walker B motif; other site 312153005275 arginine finger; other site 312153005276 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 312153005277 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153005278 active site 312153005279 catalytic residues [active] 312153005280 DNA binding site [nucleotide binding] 312153005281 Int/Topo IB signature motif; other site 312153005282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 312153005283 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153005284 active site 312153005285 catalytic residues [active] 312153005286 DNA binding site [nucleotide binding] 312153005287 Int/Topo IB signature motif; other site 312153005288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 312153005289 Walker A/P-loop; other site 312153005290 ATP binding site [chemical binding]; other site 312153005291 AAA domain; Region: AAA_21; pfam13304 312153005292 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 312153005293 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 312153005294 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 312153005295 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 312153005296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 312153005297 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 312153005298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 312153005299 DNA binding residues [nucleotide binding] 312153005300 DNA primase, catalytic core; Region: dnaG; TIGR01391 312153005301 CHC2 zinc finger; Region: zf-CHC2; pfam01807 312153005302 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 312153005303 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 312153005304 active site 312153005305 metal binding site [ion binding]; metal-binding site 312153005306 interdomain interaction site; other site 312153005307 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 312153005308 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 312153005309 Yqey-like protein; Region: YqeY; pfam09424 312153005310 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 312153005311 UGMP family protein; Validated; Region: PRK09604 312153005312 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 312153005313 putative GTP cyclohydrolase; Provisional; Region: PRK13674 312153005314 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 312153005315 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 312153005316 TPP-binding site; other site 312153005317 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 312153005318 PYR/PP interface [polypeptide binding]; other site 312153005319 dimer interface [polypeptide binding]; other site 312153005320 TPP binding site [chemical binding]; other site 312153005321 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 312153005322 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 312153005323 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 312153005324 substrate binding pocket [chemical binding]; other site 312153005325 chain length determination region; other site 312153005326 substrate-Mg2+ binding site; other site 312153005327 catalytic residues [active] 312153005328 aspartate-rich region 1; other site 312153005329 active site lid residues [active] 312153005330 aspartate-rich region 2; other site 312153005331 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 312153005332 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 312153005333 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 312153005334 [2Fe-2S] cluster binding site [ion binding]; other site 312153005335 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 312153005336 alpha subunit interface [polypeptide binding]; other site 312153005337 active site 312153005338 substrate binding site [chemical binding]; other site 312153005339 Fe binding site [ion binding]; other site 312153005340 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 312153005341 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 312153005342 active site residue [active] 312153005343 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 312153005344 active site residue [active] 312153005345 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 312153005346 ZIP Zinc transporter; Region: Zip; pfam02535 312153005347 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 312153005348 DNA polymerase I; Provisional; Region: PRK05755 312153005349 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 312153005350 active site 312153005351 metal binding site 1 [ion binding]; metal-binding site 312153005352 putative 5' ssDNA interaction site; other site 312153005353 metal binding site 3; metal-binding site 312153005354 metal binding site 2 [ion binding]; metal-binding site 312153005355 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 312153005356 putative DNA binding site [nucleotide binding]; other site 312153005357 putative metal binding site [ion binding]; other site 312153005358 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 312153005359 active site 312153005360 catalytic site [active] 312153005361 substrate binding site [chemical binding]; other site 312153005362 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 312153005363 active site 312153005364 DNA binding site [nucleotide binding] 312153005365 catalytic site [active] 312153005366 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 312153005367 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 312153005368 putative active site [active] 312153005369 putative substrate binding site [chemical binding]; other site 312153005370 ATP binding site [chemical binding]; other site 312153005371 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 312153005372 Part of AAA domain; Region: AAA_19; pfam13245 312153005373 AAA domain; Region: AAA_12; pfam13087 312153005374 Family description; Region: UvrD_C_2; pfam13538 312153005375 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 312153005376 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153005377 active site 312153005378 HIGH motif; other site 312153005379 nucleotide binding site [chemical binding]; other site 312153005380 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 312153005381 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 312153005382 active site 312153005383 KMSKS motif; other site 312153005384 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 312153005385 tRNA binding surface [nucleotide binding]; other site 312153005386 anticodon binding site; other site 312153005387 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 312153005388 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 312153005389 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 312153005390 active site 312153005391 tetramer interface; other site 312153005392 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 312153005393 CPxP motif; other site 312153005394 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 312153005395 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 312153005396 motif 1; other site 312153005397 active site 312153005398 motif 2; other site 312153005399 motif 3; other site 312153005400 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 312153005401 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 312153005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 312153005403 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 312153005404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153005405 active site 312153005406 HIGH motif; other site 312153005407 nucleotide binding site [chemical binding]; other site 312153005408 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 312153005409 KMSKS motif; other site 312153005410 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 312153005411 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 312153005412 NADH(P)-binding; Region: NAD_binding_10; pfam13460 312153005413 putative NAD(P) binding site [chemical binding]; other site 312153005414 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 312153005415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 312153005416 catalytic loop [active] 312153005417 iron binding site [ion binding]; other site 312153005418 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 312153005419 FAD binding pocket [chemical binding]; other site 312153005420 FAD binding motif [chemical binding]; other site 312153005421 phosphate binding motif [ion binding]; other site 312153005422 beta-alpha-beta structure motif; other site 312153005423 NAD binding pocket [chemical binding]; other site 312153005424 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 312153005425 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 312153005426 inhibitor-cofactor binding pocket; inhibition site 312153005427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153005428 catalytic residue [active] 312153005429 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 312153005430 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 312153005431 Walker A/P-loop; other site 312153005432 ATP binding site [chemical binding]; other site 312153005433 Q-loop/lid; other site 312153005434 ABC transporter signature motif; other site 312153005435 Walker B; other site 312153005436 D-loop; other site 312153005437 H-loop/switch region; other site 312153005438 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 312153005439 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 312153005440 Walker A/P-loop; other site 312153005441 ATP binding site [chemical binding]; other site 312153005442 Q-loop/lid; other site 312153005443 ABC transporter signature motif; other site 312153005444 Walker B; other site 312153005445 D-loop; other site 312153005446 H-loop/switch region; other site 312153005447 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 312153005448 TM-ABC transporter signature motif; other site 312153005449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 312153005450 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 312153005451 TM-ABC transporter signature motif; other site 312153005452 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 312153005453 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 312153005454 dimerization interface [polypeptide binding]; other site 312153005455 ligand binding site [chemical binding]; other site 312153005456 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 312153005457 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 312153005458 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 312153005459 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 312153005460 hypothetical protein; Reviewed; Region: PRK00024 312153005461 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 312153005462 MPN+ (JAMM) motif; other site 312153005463 Zinc-binding site [ion binding]; other site 312153005464 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 312153005465 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 312153005466 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 312153005467 Fatty acid desaturase; Region: FA_desaturase; pfam00487 312153005468 Di-iron ligands [ion binding]; other site 312153005469 Transposase; Region: DDE_Tnp_ISL3; pfam01610 312153005470 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 312153005471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153005472 S-adenosylmethionine binding site [chemical binding]; other site 312153005473 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 312153005474 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 312153005475 active site 312153005476 substrate binding site [chemical binding]; other site 312153005477 cosubstrate binding site; other site 312153005478 catalytic site [active] 312153005479 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 312153005480 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 312153005481 active site 312153005482 Riboflavin kinase; Region: Flavokinase; smart00904 312153005483 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 312153005484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 312153005485 active site 312153005486 HIGH motif; other site 312153005487 nucleotide binding site [chemical binding]; other site 312153005488 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 312153005489 active site 312153005490 KMSKS motif; other site 312153005491 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 312153005492 tRNA binding surface [nucleotide binding]; other site 312153005493 anticodon binding site; other site 312153005494 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 312153005495 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 312153005496 lipoprotein signal peptidase; Provisional; Region: PRK14787 312153005497 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 312153005498 Flavoprotein; Region: Flavoprotein; pfam02441 312153005499 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 312153005500 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 312153005501 trimer interface [polypeptide binding]; other site 312153005502 active site 312153005503 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 312153005504 nucleoside/Zn binding site; other site 312153005505 dimer interface [polypeptide binding]; other site 312153005506 catalytic motif [active] 312153005507 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 312153005508 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 312153005509 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 312153005510 Aspartase; Region: Aspartase; cd01357 312153005511 active sites [active] 312153005512 tetramer interface [polypeptide binding]; other site 312153005513 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 312153005514 Clp amino terminal domain; Region: Clp_N; pfam02861 312153005515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153005516 Walker A motif; other site 312153005517 ATP binding site [chemical binding]; other site 312153005518 Walker B motif; other site 312153005519 arginine finger; other site 312153005520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153005521 Walker A motif; other site 312153005522 ATP binding site [chemical binding]; other site 312153005523 Walker B motif; other site 312153005524 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 312153005525 Uncharacterized conserved protein [Function unknown]; Region: COG2127 312153005526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 312153005527 DNA-binding site [nucleotide binding]; DNA binding site 312153005528 RNA-binding motif; other site 312153005529 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 312153005530 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 312153005531 argininosuccinate synthase; Provisional; Region: PRK13820 312153005532 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 312153005533 ANP binding site [chemical binding]; other site 312153005534 Substrate Binding Site II [chemical binding]; other site 312153005535 Substrate Binding Site I [chemical binding]; other site 312153005536 ornithine carbamoyltransferase; Provisional; Region: PRK00779 312153005537 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 312153005538 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 312153005539 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 312153005540 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 312153005541 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 312153005542 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 312153005543 Uncharacterized conserved protein [Function unknown]; Region: COG2912 312153005544 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 312153005545 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 312153005546 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 312153005547 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 312153005548 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 312153005549 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 312153005550 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 312153005551 dimerization interface [polypeptide binding]; other site 312153005552 putative ATP binding site [chemical binding]; other site 312153005553 Domain of unknown function DUF20; Region: UPF0118; pfam01594 312153005554 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 312153005555 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 312153005556 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 312153005557 Walker A motif; other site 312153005558 ATP binding site [chemical binding]; other site 312153005559 Walker B motif; other site 312153005560 arginine finger; other site 312153005561 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 312153005562 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 312153005563 poly(A) polymerase; Region: pcnB; TIGR01942 312153005564 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 312153005565 active site 312153005566 NTP binding site [chemical binding]; other site 312153005567 metal binding triad [ion binding]; metal-binding site 312153005568 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 312153005569 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 312153005570 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 312153005571 catalytic center binding site [active] 312153005572 ATP binding site [chemical binding]; other site 312153005573 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 312153005574 oligomerization interface [polypeptide binding]; other site 312153005575 active site 312153005576 metal binding site [ion binding]; metal-binding site 312153005577 chaperone protein DnaJ; Provisional; Region: PRK10767 312153005578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 312153005579 HSP70 interaction site [polypeptide binding]; other site 312153005580 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 312153005581 Zn binding sites [ion binding]; other site 312153005582 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 312153005583 dimer interface [polypeptide binding]; other site 312153005584 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 312153005585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 312153005586 nucleotide binding site [chemical binding]; other site 312153005587 GrpE; Region: GrpE; pfam01025 312153005588 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 312153005589 dimer interface [polypeptide binding]; other site 312153005590 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 312153005591 ferrochelatase; Reviewed; Region: hemH; PRK00035 312153005592 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 312153005593 C-terminal domain interface [polypeptide binding]; other site 312153005594 active site 312153005595 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 312153005596 active site 312153005597 N-terminal domain interface [polypeptide binding]; other site 312153005598 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 312153005599 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 312153005600 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 312153005601 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 312153005602 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 312153005603 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 312153005604 Walker A/P-loop; other site 312153005605 ATP binding site [chemical binding]; other site 312153005606 Q-loop/lid; other site 312153005607 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 312153005608 ABC transporter signature motif; other site 312153005609 Walker B; other site 312153005610 D-loop; other site 312153005611 H-loop/switch region; other site 312153005612 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 312153005613 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 312153005614 metal binding triad; other site 312153005615 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 312153005616 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 312153005617 metal binding triad; other site 312153005618 TIGR02099 family protein; Region: TIGR02099 312153005619 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 312153005620 nitrilase; Region: PLN02798 312153005621 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 312153005622 putative active site [active] 312153005623 catalytic triad [active] 312153005624 dimer interface [polypeptide binding]; other site 312153005625 protease TldD; Provisional; Region: tldD; PRK10735 312153005626 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 312153005627 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 312153005628 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 312153005629 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 312153005630 FAD binding domain; Region: FAD_binding_4; pfam01565 312153005631 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 312153005632 FAD binding domain; Region: FAD_binding_4; pfam01565 312153005633 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 312153005634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 312153005635 Cysteine-rich domain; Region: CCG; pfam02754 312153005636 Cysteine-rich domain; Region: CCG; pfam02754 312153005637 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 312153005638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 312153005639 catalytic residue [active] 312153005640 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 312153005641 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 312153005642 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 312153005643 UbiA prenyltransferase family; Region: UbiA; pfam01040 312153005644 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 312153005645 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 312153005646 generic binding surface II; other site 312153005647 ssDNA binding site; other site 312153005648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 312153005649 ATP binding site [chemical binding]; other site 312153005650 putative Mg++ binding site [ion binding]; other site 312153005651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 312153005652 nucleotide binding region [chemical binding]; other site 312153005653 ATP-binding site [chemical binding]; other site 312153005654 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 312153005655 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 312153005656 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 312153005657 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 312153005658 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 312153005659 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 312153005660 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 312153005661 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 312153005662 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 312153005663 Protein export membrane protein; Region: SecD_SecF; pfam02355 312153005664 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 312153005665 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 312153005666 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153005667 adenylosuccinate lyase; Provisional; Region: PRK09285 312153005668 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 312153005669 tetramer interface [polypeptide binding]; other site 312153005670 active site 312153005671 putative glutathione S-transferase; Provisional; Region: PRK10357 312153005672 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 312153005673 putative C-terminal domain interface [polypeptide binding]; other site 312153005674 putative GSH binding site (G-site) [chemical binding]; other site 312153005675 putative dimer interface [polypeptide binding]; other site 312153005676 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 312153005677 dimer interface [polypeptide binding]; other site 312153005678 N-terminal domain interface [polypeptide binding]; other site 312153005679 putative substrate binding pocket (H-site) [chemical binding]; other site 312153005680 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 312153005681 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 312153005682 Ligand Binding Site [chemical binding]; other site 312153005683 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 312153005684 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 312153005685 ligand binding site [chemical binding]; other site 312153005686 homodimer interface [polypeptide binding]; other site 312153005687 NAD(P) binding site [chemical binding]; other site 312153005688 trimer interface B [polypeptide binding]; other site 312153005689 trimer interface A [polypeptide binding]; other site 312153005690 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 312153005691 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 312153005692 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 312153005693 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 312153005694 GDP-Fucose binding site [chemical binding]; other site 312153005695 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 312153005696 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 312153005697 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 312153005698 ring oligomerisation interface [polypeptide binding]; other site 312153005699 ATP/Mg binding site [chemical binding]; other site 312153005700 stacking interactions; other site 312153005701 hinge regions; other site 312153005702 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 312153005703 oligomerisation interface [polypeptide binding]; other site 312153005704 mobile loop; other site 312153005705 roof hairpin; other site 312153005706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 312153005707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153005708 active site 312153005709 phosphorylation site [posttranslational modification] 312153005710 intermolecular recognition site; other site 312153005711 dimerization interface [polypeptide binding]; other site 312153005712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 312153005713 DNA binding residues [nucleotide binding] 312153005714 dimerization interface [polypeptide binding]; other site 312153005715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 312153005716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153005717 dimer interface [polypeptide binding]; other site 312153005718 phosphorylation site [posttranslational modification] 312153005719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153005720 ATP binding site [chemical binding]; other site 312153005721 Mg2+ binding site [ion binding]; other site 312153005722 G-X-G motif; other site 312153005723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153005724 Response regulator receiver domain; Region: Response_reg; pfam00072 312153005725 active site 312153005726 phosphorylation site [posttranslational modification] 312153005727 intermolecular recognition site; other site 312153005728 dimerization interface [polypeptide binding]; other site 312153005729 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 312153005730 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 312153005731 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 312153005732 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 312153005733 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 312153005734 NAD(P) binding site [chemical binding]; other site 312153005735 ATP-grasp domain; Region: ATP-grasp; pfam02222 312153005736 AIR carboxylase; Region: AIRC; pfam00731 312153005737 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 312153005738 ATP binding site [chemical binding]; other site 312153005739 active site 312153005740 substrate binding site [chemical binding]; other site 312153005741 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 312153005742 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 312153005743 intersubunit interface [polypeptide binding]; other site 312153005744 active site 312153005745 zinc binding site [ion binding]; other site 312153005746 Na+ binding site [ion binding]; other site 312153005747 pyruvate kinase; Provisional; Region: PRK05826 312153005748 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 312153005749 domain interfaces; other site 312153005750 active site 312153005751 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 312153005752 Phosphoglycerate kinase; Region: PGK; pfam00162 312153005753 substrate binding site [chemical binding]; other site 312153005754 hinge regions; other site 312153005755 ADP binding site [chemical binding]; other site 312153005756 catalytic site [active] 312153005757 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 312153005758 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 312153005759 homodimer interface [polypeptide binding]; other site 312153005760 substrate-cofactor binding pocket; other site 312153005761 catalytic residue [active] 312153005762 Zinc-finger domain; Region: zf-CHCC; cl01821 312153005763 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 312153005764 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153005765 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 312153005766 putative active site [active] 312153005767 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 312153005768 SnoaL-like domain; Region: SnoaL_3; pfam13474 312153005769 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 312153005770 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 312153005771 Peptidase family M48; Region: Peptidase_M48; pfam01435 312153005772 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 312153005773 trimer interface [polypeptide binding]; other site 312153005774 dimer interface [polypeptide binding]; other site 312153005775 putative active site [active] 312153005776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005777 binding surface 312153005778 TPR motif; other site 312153005779 TPR repeat; Region: TPR_11; pfam13414 312153005780 TPR repeat; Region: TPR_11; pfam13414 312153005781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005782 binding surface 312153005783 TPR motif; other site 312153005784 TPR repeat; Region: TPR_11; pfam13414 312153005785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005786 binding surface 312153005787 TPR motif; other site 312153005788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153005789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 312153005790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153005791 Tetratricopeptide repeat; Region: TPR_16; pfam13432 312153005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005793 TPR motif; other site 312153005794 binding surface 312153005795 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 312153005796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005797 binding surface 312153005798 TPR motif; other site 312153005799 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 312153005800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153005801 binding surface 312153005802 TPR motif; other site 312153005803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 312153005804 Pilin (bacterial filament); Region: Pilin; pfam00114 312153005805 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 312153005806 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 312153005807 CoA binding domain; Region: CoA_binding; smart00881 312153005808 CoA-ligase; Region: Ligase_CoA; pfam00549 312153005809 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 312153005810 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 312153005811 CoA-ligase; Region: Ligase_CoA; pfam00549 312153005812 RecX family; Region: RecX; pfam02631 312153005813 recombinase A; Provisional; Region: recA; PRK09354 312153005814 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 312153005815 hexamer interface [polypeptide binding]; other site 312153005816 Walker A motif; other site 312153005817 ATP binding site [chemical binding]; other site 312153005818 Walker B motif; other site 312153005819 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 312153005820 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153005821 active site 312153005822 catalytic residues [active] 312153005823 DNA binding site [nucleotide binding] 312153005824 Int/Topo IB signature motif; other site 312153005825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 312153005826 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153005827 active site 312153005828 catalytic residues [active] 312153005829 DNA binding site [nucleotide binding] 312153005830 Int/Topo IB signature motif; other site 312153005831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 312153005832 MOSC domain; Region: MOSC; pfam03473 312153005833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153005834 putative substrate translocation pore; other site 312153005835 Predicted membrane protein [Function unknown]; Region: COG2860 312153005836 UPF0126 domain; Region: UPF0126; pfam03458 312153005837 UPF0126 domain; Region: UPF0126; pfam03458 312153005838 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 312153005839 maleylacetoacetate isomerase; Region: maiA; TIGR01262 312153005840 C-terminal domain interface [polypeptide binding]; other site 312153005841 GSH binding site (G-site) [chemical binding]; other site 312153005842 putative dimer interface [polypeptide binding]; other site 312153005843 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 312153005844 dimer interface [polypeptide binding]; other site 312153005845 N-terminal domain interface [polypeptide binding]; other site 312153005846 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 312153005847 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 312153005848 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 312153005849 trimer interface [polypeptide binding]; other site 312153005850 putative metal binding site [ion binding]; other site 312153005851 OsmC-like protein; Region: OsmC; pfam02566 312153005852 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 312153005853 active site 312153005854 catalytic residue [active] 312153005855 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 312153005856 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 312153005857 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 312153005858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153005859 FeS/SAM binding site; other site 312153005860 TRAM domain; Region: TRAM; pfam01938 312153005861 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 312153005862 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 312153005863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 312153005864 Transporter associated domain; Region: CorC_HlyC; smart01091 312153005865 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 312153005866 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 312153005867 putative active site [active] 312153005868 catalytic triad [active] 312153005869 putative dimer interface [polypeptide binding]; other site 312153005870 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 312153005871 dimer interface [polypeptide binding]; other site 312153005872 motif 1; other site 312153005873 active site 312153005874 motif 2; other site 312153005875 motif 3; other site 312153005876 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 312153005877 DALR anticodon binding domain; Region: DALR_1; pfam05746 312153005878 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 312153005879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 312153005880 active site 312153005881 motif I; other site 312153005882 motif II; other site 312153005883 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 312153005884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 312153005885 putative acyl-acceptor binding pocket; other site 312153005886 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 312153005887 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 312153005888 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 312153005889 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 312153005890 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 312153005891 SurA N-terminal domain; Region: SurA_N; pfam09312 312153005892 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 312153005893 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 312153005894 OstA-like protein; Region: OstA; cl00844 312153005895 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 312153005896 Organic solvent tolerance protein; Region: OstA_C; pfam04453 312153005897 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 312153005898 Phosphotransferase enzyme family; Region: APH; pfam01636 312153005899 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 312153005900 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 312153005901 Substrate binding site; other site 312153005902 metal-binding site 312153005903 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 312153005904 proline aminopeptidase P II; Provisional; Region: PRK10879 312153005905 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 312153005906 active site 312153005907 hypothetical protein; Provisional; Region: PRK06996 312153005908 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 312153005909 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 312153005910 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 312153005911 FMN binding site [chemical binding]; other site 312153005912 active site 312153005913 catalytic residues [active] 312153005914 substrate binding site [chemical binding]; other site 312153005915 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 312153005916 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 312153005917 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 312153005918 purine monophosphate binding site [chemical binding]; other site 312153005919 dimer interface [polypeptide binding]; other site 312153005920 putative catalytic residues [active] 312153005921 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 312153005922 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 312153005923 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 312153005924 active site 312153005925 putative DNA-binding cleft [nucleotide binding]; other site 312153005926 dimer interface [polypeptide binding]; other site 312153005927 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 312153005928 RuvA N terminal domain; Region: RuvA_N; pfam01330 312153005929 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 312153005930 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 312153005931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153005932 Walker A motif; other site 312153005933 ATP binding site [chemical binding]; other site 312153005934 Walker B motif; other site 312153005935 arginine finger; other site 312153005936 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 312153005937 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 312153005938 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 312153005939 active site 312153005940 HIGH motif; other site 312153005941 dimer interface [polypeptide binding]; other site 312153005942 KMSKS motif; other site 312153005943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153005944 RNA binding surface [nucleotide binding]; other site 312153005945 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 312153005946 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 312153005947 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 312153005948 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 312153005949 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 312153005950 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 312153005951 23S rRNA interface [nucleotide binding]; other site 312153005952 L3 interface [polypeptide binding]; other site 312153005953 OsmC-like protein; Region: OsmC; cl00767 312153005954 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 312153005955 active site 312153005956 substrate binding pocket [chemical binding]; other site 312153005957 dimer interface [polypeptide binding]; other site 312153005958 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 312153005959 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 312153005960 MOFRL family; Region: MOFRL; pfam05161 312153005961 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 312153005962 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 312153005963 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 312153005964 Walker A/P-loop; other site 312153005965 ATP binding site [chemical binding]; other site 312153005966 Q-loop/lid; other site 312153005967 ABC transporter signature motif; other site 312153005968 Walker B; other site 312153005969 D-loop; other site 312153005970 H-loop/switch region; other site 312153005971 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 312153005972 nudix motif; other site 312153005973 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 312153005974 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 312153005975 dimer interface [polypeptide binding]; other site 312153005976 anticodon binding site; other site 312153005977 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 312153005978 homodimer interface [polypeptide binding]; other site 312153005979 motif 1; other site 312153005980 active site 312153005981 motif 2; other site 312153005982 GAD domain; Region: GAD; pfam02938 312153005983 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 312153005984 motif 3; other site 312153005985 Uncharacterized conserved protein [Function unknown]; Region: COG2928 312153005986 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 312153005987 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 312153005988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 312153005989 SCP-2 sterol transfer family; Region: SCP2; pfam02036 312153005990 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 312153005991 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 312153005992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153005993 S-adenosylmethionine binding site [chemical binding]; other site 312153005994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 312153005995 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 312153005996 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 312153005997 FAD binding domain; Region: FAD_binding_4; pfam01565 312153005998 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 312153005999 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 312153006000 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 312153006001 Cysteine-rich domain; Region: CCG; pfam02754 312153006002 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 312153006003 threonine dehydratase; Reviewed; Region: PRK09224 312153006004 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 312153006005 tetramer interface [polypeptide binding]; other site 312153006006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 312153006007 catalytic residue [active] 312153006008 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 312153006009 putative Ile/Val binding site [chemical binding]; other site 312153006010 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 312153006011 putative Ile/Val binding site [chemical binding]; other site 312153006012 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 312153006013 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 312153006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 312153006015 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 312153006016 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 312153006017 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 312153006018 dimer interface [polypeptide binding]; other site 312153006019 ssDNA binding site [nucleotide binding]; other site 312153006020 tetramer (dimer of dimers) interface [polypeptide binding]; other site 312153006021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 312153006022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 312153006023 putative substrate translocation pore; other site 312153006024 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 312153006025 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 312153006026 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 312153006027 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 312153006028 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 312153006029 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 312153006030 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 312153006031 TrkA-N domain; Region: TrkA_N; pfam02254 312153006032 TrkA-C domain; Region: TrkA_C; pfam02080 312153006033 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 312153006034 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 312153006035 putative active site [active] 312153006036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 312153006037 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 312153006038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 312153006039 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 312153006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 312153006041 OstA-like protein; Region: OstA; cl00844 312153006042 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 312153006043 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 312153006044 Walker A/P-loop; other site 312153006045 ATP binding site [chemical binding]; other site 312153006046 Q-loop/lid; other site 312153006047 ABC transporter signature motif; other site 312153006048 Walker B; other site 312153006049 D-loop; other site 312153006050 H-loop/switch region; other site 312153006051 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 312153006052 30S subunit binding site; other site 312153006053 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 312153006054 active site 312153006055 phosphorylation site [posttranslational modification] 312153006056 HPr kinase/phosphorylase; Provisional; Region: PRK05428 312153006057 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 312153006058 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 312153006059 Hpr binding site; other site 312153006060 active site 312153006061 homohexamer subunit interaction site [polypeptide binding]; other site 312153006062 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 312153006063 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 312153006064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 312153006065 minor groove reading motif; other site 312153006066 helix-hairpin-helix signature motif; other site 312153006067 substrate binding pocket [chemical binding]; other site 312153006068 active site 312153006069 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 312153006070 DNA binding and oxoG recognition site [nucleotide binding] 312153006071 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 312153006072 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 312153006073 DNA binding site [nucleotide binding] 312153006074 catalytic residue [active] 312153006075 H2TH interface [polypeptide binding]; other site 312153006076 putative catalytic residues [active] 312153006077 turnover-facilitating residue; other site 312153006078 intercalation triad [nucleotide binding]; other site 312153006079 8OG recognition residue [nucleotide binding]; other site 312153006080 putative reading head residues; other site 312153006081 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 312153006082 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 312153006083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153006084 TPR motif; other site 312153006085 TPR repeat; Region: TPR_11; pfam13414 312153006086 binding surface 312153006087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 312153006088 binding surface 312153006089 TPR motif; other site 312153006090 TPR repeat; Region: TPR_11; pfam13414 312153006091 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 312153006092 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 312153006093 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 312153006094 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 312153006095 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 312153006096 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 312153006097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153006098 active site 312153006099 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 312153006100 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 312153006101 5S rRNA interface [nucleotide binding]; other site 312153006102 CTC domain interface [polypeptide binding]; other site 312153006103 L16 interface [polypeptide binding]; other site 312153006104 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 312153006105 putative active site [active] 312153006106 catalytic residue [active] 312153006107 Ferredoxin [Energy production and conversion]; Region: COG1146 312153006108 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 312153006109 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 312153006110 active site 312153006111 (T/H)XGH motif; other site 312153006112 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 312153006113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153006114 S-adenosylmethionine binding site [chemical binding]; other site 312153006115 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 312153006116 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 312153006117 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 312153006118 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 312153006119 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 312153006120 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 312153006121 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 312153006122 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 312153006123 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 312153006124 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 312153006125 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 312153006126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 312153006127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 312153006128 DNA binding residues [nucleotide binding] 312153006129 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 312153006130 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 312153006131 Cu(I) binding site [ion binding]; other site 312153006132 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 312153006133 UbiA prenyltransferase family; Region: UbiA; pfam01040 312153006134 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 312153006135 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 312153006136 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 312153006137 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 312153006138 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 312153006139 Subunit III/VIIa interface [polypeptide binding]; other site 312153006140 Phospholipid binding site [chemical binding]; other site 312153006141 Subunit I/III interface [polypeptide binding]; other site 312153006142 Subunit III/VIb interface [polypeptide binding]; other site 312153006143 Subunit III/VIa interface; other site 312153006144 Subunit III/Vb interface [polypeptide binding]; other site 312153006145 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 312153006146 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 312153006147 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 312153006148 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 312153006149 Subunit I/III interface [polypeptide binding]; other site 312153006150 D-pathway; other site 312153006151 Subunit I/VIIc interface [polypeptide binding]; other site 312153006152 Subunit I/IV interface [polypeptide binding]; other site 312153006153 Subunit I/II interface [polypeptide binding]; other site 312153006154 Low-spin heme (heme a) binding site [chemical binding]; other site 312153006155 Subunit I/VIIa interface [polypeptide binding]; other site 312153006156 Subunit I/VIa interface [polypeptide binding]; other site 312153006157 Dimer interface; other site 312153006158 Putative water exit pathway; other site 312153006159 Binuclear center (heme a3/CuB) [ion binding]; other site 312153006160 K-pathway; other site 312153006161 Subunit I/Vb interface [polypeptide binding]; other site 312153006162 Putative proton exit pathway; other site 312153006163 Subunit I/VIb interface; other site 312153006164 Subunit I/VIc interface [polypeptide binding]; other site 312153006165 Electron transfer pathway; other site 312153006166 Subunit I/VIIIb interface [polypeptide binding]; other site 312153006167 Subunit I/VIIb interface [polypeptide binding]; other site 312153006168 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 312153006169 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 312153006170 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 312153006171 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 312153006172 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 312153006173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153006174 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 312153006175 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 312153006176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153006177 active site 312153006178 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 312153006179 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 312153006180 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 312153006181 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 312153006182 preprotein translocase subunit SecB; Validated; Region: PRK05751 312153006183 SecA binding site; other site 312153006184 Preprotein binding site; other site 312153006185 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 312153006186 GSH binding site [chemical binding]; other site 312153006187 catalytic residues [active] 312153006188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 312153006189 active site residue [active] 312153006190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 312153006191 catalytic core [active] 312153006192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 312153006193 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 312153006194 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 312153006195 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 312153006196 protein binding site [polypeptide binding]; other site 312153006197 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 312153006198 Catalytic dyad [active] 312153006199 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 312153006200 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 312153006201 ATP binding site [chemical binding]; other site 312153006202 substrate interface [chemical binding]; other site 312153006203 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 312153006204 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 312153006205 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 312153006206 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 312153006207 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 312153006208 dimerization domain swap beta strand [polypeptide binding]; other site 312153006209 regulatory protein interface [polypeptide binding]; other site 312153006210 active site 312153006211 regulatory phosphorylation site [posttranslational modification]; other site 312153006212 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 312153006213 active pocket/dimerization site; other site 312153006214 active site 312153006215 phosphorylation site [posttranslational modification] 312153006216 glutathione synthetase; Provisional; Region: PRK05246 312153006217 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 312153006218 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 312153006219 Glutamate-cysteine ligase; Region: GshA; pfam08886 312153006220 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 312153006221 ammonium transporter; Provisional; Region: PRK10666 312153006222 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 312153006223 Nitrogen regulatory protein P-II; Region: P-II; smart00938 312153006224 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 312153006225 Membrane fusogenic activity; Region: BMFP; pfam04380 312153006226 lipoyl synthase; Provisional; Region: PRK05481 312153006227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 312153006228 FeS/SAM binding site; other site 312153006229 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 312153006230 Protein of unknown function (DUF493); Region: DUF493; cl01102 312153006231 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 312153006232 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 312153006233 dimer interface [polypeptide binding]; other site 312153006234 [2Fe-2S] cluster binding site [ion binding]; other site 312153006235 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 312153006236 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 312153006237 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 312153006238 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 312153006239 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 312153006240 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 312153006241 active site 312153006242 nucleotide binding site [chemical binding]; other site 312153006243 HIGH motif; other site 312153006244 KMSKS motif; other site 312153006245 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 312153006246 catalytic residues [active] 312153006247 dimer interface [polypeptide binding]; other site 312153006248 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 312153006249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 312153006250 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 312153006251 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 312153006252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153006253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153006254 S-adenosylmethionine binding site [chemical binding]; other site 312153006255 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 312153006256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 312153006257 NAD(P) binding site [chemical binding]; other site 312153006258 active site 312153006259 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 312153006260 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 312153006261 catalytic residues [active] 312153006262 hinge region; other site 312153006263 alpha helical domain; other site 312153006264 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 312153006265 Sporulation related domain; Region: SPOR; pfam05036 312153006266 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 312153006267 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 312153006268 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 312153006269 active site 312153006270 HIGH motif; other site 312153006271 KMSK motif region; other site 312153006272 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 312153006273 tRNA binding surface [nucleotide binding]; other site 312153006274 anticodon binding site; other site 312153006275 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 312153006276 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 312153006277 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 312153006278 substrate binding pocket [chemical binding]; other site 312153006279 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 312153006280 B12 binding site [chemical binding]; other site 312153006281 cobalt ligand [ion binding]; other site 312153006282 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 312153006283 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 312153006284 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 312153006285 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 312153006286 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 312153006287 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 312153006288 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 312153006289 NADP binding site [chemical binding]; other site 312153006290 dimer interface [polypeptide binding]; other site 312153006291 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 312153006292 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 312153006293 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 312153006294 putative C-terminal domain interface [polypeptide binding]; other site 312153006295 putative GSH binding site (G-site) [chemical binding]; other site 312153006296 putative dimer interface [polypeptide binding]; other site 312153006297 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 312153006298 N-terminal domain interface [polypeptide binding]; other site 312153006299 dimer interface [polypeptide binding]; other site 312153006300 substrate binding pocket (H-site) [chemical binding]; other site 312153006301 multidrug efflux protein; Reviewed; Region: PRK09579 312153006302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 312153006303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 312153006304 HlyD family secretion protein; Region: HlyD_3; pfam13437 312153006305 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 312153006306 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 312153006307 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 312153006308 glutaminase active site [active] 312153006309 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 312153006310 dimer interface [polypeptide binding]; other site 312153006311 active site 312153006312 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 312153006313 dimer interface [polypeptide binding]; other site 312153006314 active site 312153006315 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 312153006316 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 312153006317 Substrate binding site; other site 312153006318 Mg++ binding site; other site 312153006319 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 312153006320 active site 312153006321 substrate binding site [chemical binding]; other site 312153006322 CoA binding site [chemical binding]; other site 312153006323 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 312153006324 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 312153006325 Ligand Binding Site [chemical binding]; other site 312153006326 Dihydroneopterin aldolase; Region: FolB; smart00905 312153006327 active site 312153006328 short chain dehydrogenase; Provisional; Region: PRK09134 312153006329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 312153006330 NAD(P) binding site [chemical binding]; other site 312153006331 active site 312153006332 Uncharacterized conserved protein [Function unknown]; Region: COG1565 312153006333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 312153006334 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 312153006335 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 312153006336 active site 312153006337 NTP binding site [chemical binding]; other site 312153006338 metal binding triad [ion binding]; metal-binding site 312153006339 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 312153006340 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 312153006341 NADH(P)-binding; Region: NAD_binding_10; pfam13460 312153006342 putative NAD(P) binding site [chemical binding]; other site 312153006343 active site 312153006344 lytic murein transglycosylase; Provisional; Region: PRK11619 312153006345 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 312153006346 N-acetyl-D-glucosamine binding site [chemical binding]; other site 312153006347 catalytic residue [active] 312153006348 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 312153006349 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 312153006350 FAD binding site [chemical binding]; other site 312153006351 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 312153006352 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 312153006353 homotetramer interface [polypeptide binding]; other site 312153006354 ligand binding site [chemical binding]; other site 312153006355 catalytic site [active] 312153006356 NAD binding site [chemical binding]; other site 312153006357 S-adenosylmethionine synthetase; Validated; Region: PRK05250 312153006358 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 312153006359 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 312153006360 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 312153006361 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 312153006362 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 312153006363 putative acyl-acceptor binding pocket; other site 312153006364 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 312153006365 putative acyl-acceptor binding pocket; other site 312153006366 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 312153006367 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 312153006368 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 312153006369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 312153006370 active site 312153006371 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 312153006372 putative active site [active] 312153006373 putative catalytic site [active] 312153006374 putative DNA binding site [nucleotide binding]; other site 312153006375 putative phosphate binding site [ion binding]; other site 312153006376 metal binding site A [ion binding]; metal-binding site 312153006377 putative AP binding site [nucleotide binding]; other site 312153006378 putative metal binding site B [ion binding]; other site 312153006379 muropeptide transporter; Reviewed; Region: ampG; PRK11902 312153006380 AmpG-like permease; Region: 2A0125; TIGR00901 312153006381 Methyltransferase domain; Region: Methyltransf_23; pfam13489 312153006382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153006383 S-adenosylmethionine binding site [chemical binding]; other site 312153006384 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 312153006385 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 312153006386 division inhibitor protein; Provisional; Region: slmA; PRK09480 312153006387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 312153006388 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 312153006389 feedback inhibition sensing region; other site 312153006390 homohexameric interface [polypeptide binding]; other site 312153006391 nucleotide binding site [chemical binding]; other site 312153006392 N-acetyl-L-glutamate binding site [chemical binding]; other site 312153006393 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 312153006394 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 312153006395 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 312153006396 P-loop, Walker A motif; other site 312153006397 Base recognition motif; other site 312153006398 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 312153006399 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 312153006400 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 312153006401 active site 312153006402 DNA binding site [nucleotide binding] 312153006403 Int/Topo IB signature motif; other site 312153006404 Protein of unknown function, DUF484; Region: DUF484; cl17449 312153006405 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 312153006406 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 312153006407 GatB domain; Region: GatB_Yqey; smart00845 312153006408 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 312153006409 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 312153006410 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 312153006411 rod shape-determining protein MreB; Provisional; Region: PRK13927 312153006412 MreB and similar proteins; Region: MreB_like; cd10225 312153006413 nucleotide binding site [chemical binding]; other site 312153006414 Mg binding site [ion binding]; other site 312153006415 putative protofilament interaction site [polypeptide binding]; other site 312153006416 RodZ interaction site [polypeptide binding]; other site 312153006417 rod shape-determining protein MreC; Provisional; Region: PRK13922 312153006418 rod shape-determining protein MreC; Region: MreC; pfam04085 312153006419 rod shape-determining protein MreD; Region: MreD; cl01087 312153006420 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 312153006421 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 312153006422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 312153006423 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 312153006424 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 312153006425 IHF - DNA interface [nucleotide binding]; other site 312153006426 IHF dimer interface [polypeptide binding]; other site 312153006427 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 312153006428 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 312153006429 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 312153006430 active site clefts [active] 312153006431 zinc binding site [ion binding]; other site 312153006432 dimer interface [polypeptide binding]; other site 312153006433 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 312153006434 putative acyl-acceptor binding pocket; other site 312153006435 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 312153006436 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 312153006437 active site 312153006438 metal binding site [ion binding]; metal-binding site 312153006439 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 312153006440 Catalytic domain of Protein Kinases; Region: PKc; cd00180 312153006441 active site 312153006442 ATP binding site [chemical binding]; other site 312153006443 substrate binding site [chemical binding]; other site 312153006444 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 312153006445 substrate binding site [chemical binding]; other site 312153006446 activation loop (A-loop); other site 312153006447 activation loop (A-loop); other site 312153006448 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 312153006449 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 312153006450 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 312153006451 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 312153006452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 312153006453 RNA binding surface [nucleotide binding]; other site 312153006454 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 312153006455 active site 312153006456 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 312153006457 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 312153006458 putative GEF interaction site [polypeptide binding]; other site 312153006459 Switch I region; other site 312153006460 G2 box; other site 312153006461 G3 box; other site 312153006462 Switch II region; other site 312153006463 GTP/Mg2+ binding site [chemical binding]; other site 312153006464 G4 box; other site 312153006465 G5 box; other site 312153006466 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 312153006467 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 312153006468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 312153006469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 312153006470 Coenzyme A binding pocket [chemical binding]; other site 312153006471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 312153006472 catalytic core [active] 312153006473 MltA-interacting protein MipA; Region: MipA; cl01504 312153006474 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 312153006475 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 312153006476 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 312153006477 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 312153006478 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 312153006479 dimer interface [polypeptide binding]; other site 312153006480 active site 312153006481 heme binding site [chemical binding]; other site 312153006482 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 312153006483 MAPEG family; Region: MAPEG; cl09190 312153006484 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 312153006485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 312153006486 motif II; other site 312153006487 Protein of unknown function, DUF486; Region: DUF486; cl01236 312153006488 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 312153006489 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 312153006490 hydrophobic ligand binding site; other site 312153006491 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 312153006492 putative heme binding pocket [chemical binding]; other site 312153006493 CHRD domain; Region: CHRD; pfam07452 312153006494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 312153006495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 312153006496 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 312153006497 putative dimerization interface [polypeptide binding]; other site 312153006498 Domain of unknown function (DUF897); Region: DUF897; pfam05982 312153006499 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 312153006500 putative uracil binding site [chemical binding]; other site 312153006501 putative active site [active] 312153006502 Inward rectifier potassium channel; Region: IRK; pfam01007 312153006503 Patatin-like phospholipase; Region: Patatin; pfam01734 312153006504 active site 312153006505 nucleophile elbow; other site 312153006506 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153006507 active site 312153006508 catalytic residues [active] 312153006509 DNA binding site [nucleotide binding] 312153006510 Int/Topo IB signature motif; other site 312153006511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 312153006512 Walker A motif; other site 312153006513 ATP binding site [chemical binding]; other site 312153006514 Walker B motif; other site 312153006515 arginine finger; other site 312153006516 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 312153006517 active site 312153006518 catalytic residues [active] 312153006519 DNA binding site [nucleotide binding] 312153006520 Int/Topo IB signature motif; other site 312153006521 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 312153006522 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 312153006523 YcaO domain protein; Region: TIGR03549 312153006524 OsmC-like protein; Region: OsmC; pfam02566 312153006525 YcaO-like family; Region: YcaO; pfam02624 312153006526 Response regulator receiver domain; Region: Response_reg; pfam00072 312153006527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 312153006528 active site 312153006529 phosphorylation site [posttranslational modification] 312153006530 intermolecular recognition site; other site 312153006531 dimerization interface [polypeptide binding]; other site 312153006532 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 312153006533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 312153006534 dimerization interface [polypeptide binding]; other site 312153006535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 312153006536 dimer interface [polypeptide binding]; other site 312153006537 phosphorylation site [posttranslational modification] 312153006538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 312153006539 ATP binding site [chemical binding]; other site 312153006540 Mg2+ binding site [ion binding]; other site 312153006541 G-X-G motif; other site 312153006542 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 312153006543 16S rRNA methyltransferase B; Provisional; Region: PRK10901 312153006544 NusB family; Region: NusB; pfam01029 312153006545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 312153006546 S-adenosylmethionine binding site [chemical binding]; other site 312153006547 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 312153006548 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 312153006549 putative active site [active] 312153006550 substrate binding site [chemical binding]; other site 312153006551 putative cosubstrate binding site; other site 312153006552 catalytic site [active] 312153006553 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 312153006554 substrate binding site [chemical binding]; other site 312153006555 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 312153006556 active site 312153006557 catalytic residues [active] 312153006558 metal binding site [ion binding]; metal-binding site 312153006559 DNA protecting protein DprA; Region: dprA; TIGR00732 312153006560 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 312153006561 DNA topoisomerase III; Validated; Region: PRK08173 312153006562 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 312153006563 active site 312153006564 putative interdomain interaction site [polypeptide binding]; other site 312153006565 putative metal-binding site [ion binding]; other site 312153006566 putative nucleotide binding site [chemical binding]; other site 312153006567 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 312153006568 domain I; other site 312153006569 DNA binding groove [nucleotide binding] 312153006570 phosphate binding site [ion binding]; other site 312153006571 domain II; other site 312153006572 domain III; other site 312153006573 nucleotide binding site [chemical binding]; other site 312153006574 catalytic site [active] 312153006575 domain IV; other site 312153006576 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 312153006577 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 312153006578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 312153006579 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 312153006580 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 312153006581 active site 312153006582 substrate-binding site [chemical binding]; other site 312153006583 metal-binding site [ion binding] 312153006584 GTP binding site [chemical binding]; other site 312153006585 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 312153006586 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 312153006587 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 312153006588 GTP/Mg2+ binding site [chemical binding]; other site 312153006589 G4 box; other site 312153006590 G5 box; other site 312153006591 trmE is a tRNA modification GTPase; Region: trmE; cd04164 312153006592 G1 box; other site 312153006593 G1 box; other site 312153006594 GTP/Mg2+ binding site [chemical binding]; other site 312153006595 Switch I region; other site 312153006596 Switch I region; other site 312153006597 G2 box; other site 312153006598 G2 box; other site 312153006599 Switch II region; other site 312153006600 G3 box; other site 312153006601 G4 box; other site 312153006602 G5 box; other site 312153006603 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 312153006604 membrane protein insertase; Provisional; Region: PRK01318 312153006605 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 312153006606 Haemolytic domain; Region: Haemolytic; pfam01809 312153006607 Ribonuclease P; Region: Ribonuclease_P; cl00457 312153006608 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399