-- dump date 20140619_235434 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767031000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 767031000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 767031000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031000004 Walker A motif; other site 767031000005 ATP binding site [chemical binding]; other site 767031000006 Walker B motif; other site 767031000007 arginine finger; other site 767031000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767031000009 DnaA box-binding interface [nucleotide binding]; other site 767031000010 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 767031000011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031000012 Zn2+ binding site [ion binding]; other site 767031000013 Mg2+ binding site [ion binding]; other site 767031000014 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 767031000015 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 767031000016 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 767031000017 trimer interface [polypeptide binding]; other site 767031000018 active site 767031000019 UDP-GlcNAc binding site [chemical binding]; other site 767031000020 lipid binding site [chemical binding]; lipid-binding site 767031000021 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 767031000022 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 767031000023 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767031000024 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 767031000025 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 767031000026 active site 767031000027 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767031000028 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767031000029 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 767031000030 Transglycosylase; Region: Transgly; pfam00912 767031000031 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767031000032 PIF1-like helicase; Region: PIF1; pfam05970 767031000033 AAA domain; Region: AAA_30; pfam13604 767031000034 Family description; Region: UvrD_C_2; pfam13538 767031000035 MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299 767031000036 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031000037 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767031000038 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031000039 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031000040 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031000041 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767031000042 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031000043 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031000044 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031000045 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031000046 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031000047 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 767031000048 active site 767031000049 DNA polymerase IV; Validated; Region: PRK02406 767031000050 DNA binding site [nucleotide binding] 767031000051 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767031000052 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 767031000053 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 767031000054 SLBB domain; Region: SLBB; pfam10531 767031000055 SLBB domain; Region: SLBB; pfam10531 767031000056 SLBB domain; Region: SLBB; pfam10531 767031000057 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 767031000058 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 767031000059 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 767031000060 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 767031000061 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 767031000062 Chain length determinant protein; Region: Wzz; cl15801 767031000063 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767031000064 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 767031000065 CoA binding site [chemical binding]; other site 767031000066 active site 767031000067 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 767031000068 putative ligand binding site [chemical binding]; other site 767031000069 putative catalytic site [active] 767031000070 LicD family; Region: LicD; pfam04991 767031000071 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 767031000072 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 767031000073 active site 767031000074 metal-binding site 767031000075 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 767031000076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767031000077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031000078 homodimer interface [polypeptide binding]; other site 767031000079 catalytic residue [active] 767031000080 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 767031000081 metal-binding site 767031000082 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 767031000083 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 767031000084 Mg++ binding site [ion binding]; other site 767031000085 putative catalytic motif [active] 767031000086 substrate binding site [chemical binding]; other site 767031000087 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 767031000088 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 767031000089 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031000090 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 767031000091 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767031000092 active site 767031000093 metal binding site [ion binding]; metal-binding site 767031000094 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767031000095 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 767031000096 active site 767031000097 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767031000098 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767031000099 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 767031000100 homotrimer interaction site [polypeptide binding]; other site 767031000101 putative active site [active] 767031000102 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 767031000103 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 767031000104 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 767031000105 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 767031000106 GTPase CgtA; Reviewed; Region: obgE; PRK12299 767031000107 GTP1/OBG; Region: GTP1_OBG; pfam01018 767031000108 Obg GTPase; Region: Obg; cd01898 767031000109 G1 box; other site 767031000110 GTP/Mg2+ binding site [chemical binding]; other site 767031000111 Switch I region; other site 767031000112 G2 box; other site 767031000113 G3 box; other site 767031000114 Switch II region; other site 767031000115 G4 box; other site 767031000116 G5 box; other site 767031000117 adenylate kinase; Reviewed; Region: adk; PRK00279 767031000118 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767031000119 AMP-binding site [chemical binding]; other site 767031000120 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767031000121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031000122 active site 767031000123 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 767031000124 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767031000125 putative substrate binding site [chemical binding]; other site 767031000126 putative ATP binding site [chemical binding]; other site 767031000127 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 767031000128 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 767031000129 intersubunit interface [polypeptide binding]; other site 767031000130 active site 767031000131 zinc binding site [ion binding]; other site 767031000132 Na+ binding site [ion binding]; other site 767031000133 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767031000134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031000135 active site 767031000136 motif I; other site 767031000137 motif II; other site 767031000138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031000139 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 767031000140 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 767031000141 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 767031000142 excinuclease ABC subunit B; Provisional; Region: PRK05298 767031000143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031000144 ATP binding site [chemical binding]; other site 767031000145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031000146 nucleotide binding region [chemical binding]; other site 767031000147 ATP-binding site [chemical binding]; other site 767031000148 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767031000149 UvrB/uvrC motif; Region: UVR; pfam02151 767031000150 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 767031000151 Part of AAA domain; Region: AAA_19; pfam13245 767031000152 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 767031000153 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767031000154 active site 767031000155 catalytic site [active] 767031000156 substrate binding site [chemical binding]; other site 767031000157 Family description; Region: UvrD_C_2; pfam13538 767031000158 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767031000159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031000160 Response regulator receiver domain; Region: Response_reg; pfam00072 767031000161 active site 767031000162 phosphorylation site [posttranslational modification] 767031000163 intermolecular recognition site; other site 767031000164 dimerization interface [polypeptide binding]; other site 767031000165 PglZ domain; Region: PglZ; pfam08665 767031000166 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 767031000167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031000168 TPR motif; other site 767031000169 binding surface 767031000170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767031000171 binding surface 767031000172 TPR motif; other site 767031000173 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 767031000174 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 767031000175 hinge; other site 767031000176 active site 767031000177 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 767031000178 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 767031000179 metal binding site [ion binding]; metal-binding site 767031000180 dimer interface [polypeptide binding]; other site 767031000181 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 767031000182 M6 family metalloprotease domain; Region: M6dom_TIGR03296 767031000183 SurA N-terminal domain; Region: SurA_N_2; pfam13623 767031000184 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 767031000185 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 767031000186 Domain of unknown function DUF21; Region: DUF21; pfam01595 767031000187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767031000188 Transporter associated domain; Region: CorC_HlyC; smart01091 767031000189 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 767031000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031000191 putative transporter; Provisional; Region: PRK10504 767031000192 putative substrate translocation pore; other site 767031000193 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 767031000194 HemN C-terminal domain; Region: HemN_C; pfam06969 767031000195 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 767031000196 elongation factor G; Reviewed; Region: PRK12740 767031000197 G1 box; other site 767031000198 putative GEF interaction site [polypeptide binding]; other site 767031000199 GTP/Mg2+ binding site [chemical binding]; other site 767031000200 Switch I region; other site 767031000201 G2 box; other site 767031000202 G3 box; other site 767031000203 Switch II region; other site 767031000204 G4 box; other site 767031000205 G5 box; other site 767031000206 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767031000207 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767031000208 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767031000209 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 767031000210 catalytic residues [active] 767031000211 dimer interface [polypeptide binding]; other site 767031000212 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767031000213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767031000214 RNA binding surface [nucleotide binding]; other site 767031000215 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767031000216 active site 767031000217 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767031000218 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 767031000219 pyruvate kinase; Provisional; Region: PRK05826 767031000220 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 767031000221 domain interfaces; other site 767031000222 active site 767031000223 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 767031000224 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767031000225 YceG-like family; Region: YceG; pfam02618 767031000226 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 767031000227 dimerization interface [polypeptide binding]; other site 767031000228 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767031000229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031000230 motif II; other site 767031000231 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 767031000232 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 767031000233 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 767031000234 shikimate binding site; other site 767031000235 NAD(P) binding site [chemical binding]; other site 767031000236 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 767031000237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031000238 S-adenosylmethionine binding site [chemical binding]; other site 767031000239 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 767031000240 ATP binding site [chemical binding]; other site 767031000241 active site 767031000242 substrate binding site [chemical binding]; other site 767031000243 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767031000244 PhoH-like protein; Region: PhoH; pfam02562 767031000245 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 767031000246 Ligand Binding Site [chemical binding]; other site 767031000247 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 767031000248 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 767031000249 FAD binding pocket [chemical binding]; other site 767031000250 FAD binding motif [chemical binding]; other site 767031000251 phosphate binding motif [ion binding]; other site 767031000252 beta-alpha-beta structure motif; other site 767031000253 NAD binding pocket [chemical binding]; other site 767031000254 Iron coordination center [ion binding]; other site 767031000255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767031000256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767031000257 seryl-tRNA synthetase; Provisional; Region: PRK05431 767031000258 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767031000259 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767031000260 dimer interface [polypeptide binding]; other site 767031000261 active site 767031000262 motif 1; other site 767031000263 motif 2; other site 767031000264 motif 3; other site 767031000265 TPR repeat; Region: TPR_11; pfam13414 767031000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031000267 TPR motif; other site 767031000268 TPR repeat; Region: TPR_11; pfam13414 767031000269 binding surface 767031000270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031000271 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767031000272 active site 767031000273 catalytic residues [active] 767031000274 metal binding site [ion binding]; metal-binding site 767031000275 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 767031000276 Sporulation related domain; Region: SPOR; pfam05036 767031000277 YtxH-like protein; Region: YtxH; pfam12732 767031000278 YARHG domain; Region: YARHG; pfam13308 767031000279 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 767031000280 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 767031000281 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 767031000282 putative active site [active] 767031000283 putative metal binding site [ion binding]; other site 767031000284 A new structural DNA glycosylase; Region: AlkD_like; cd06561 767031000285 active site 767031000286 Protein of unknown function (DUF721); Region: DUF721; pfam05258 767031000287 recombination protein F; Reviewed; Region: recF; PRK00064 767031000288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031000289 Walker A/P-loop; other site 767031000290 ATP binding site [chemical binding]; other site 767031000291 Q-loop/lid; other site 767031000292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031000293 ABC transporter signature motif; other site 767031000294 Walker B; other site 767031000295 D-loop; other site 767031000296 H-loop/switch region; other site 767031000297 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 767031000298 homopentamer interface [polypeptide binding]; other site 767031000299 active site 767031000300 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031000301 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031000302 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031000303 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767031000304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767031000305 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767031000306 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 767031000307 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 767031000308 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 767031000309 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000310 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000311 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 767031000312 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 767031000313 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000314 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000315 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000316 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767031000317 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 767031000318 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 767031000319 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767031000320 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767031000321 active site 767031000322 oxyanion hole [active] 767031000323 catalytic triad [active] 767031000324 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 767031000325 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767031000326 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 767031000327 putative NAD(P) binding site [chemical binding]; other site 767031000328 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 767031000329 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031000330 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 767031000331 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767031000332 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767031000333 active site 767031000334 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 767031000335 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 767031000336 NAD(P) binding site [chemical binding]; other site 767031000337 homotetramer interface [polypeptide binding]; other site 767031000338 homodimer interface [polypeptide binding]; other site 767031000339 active site 767031000340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767031000341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767031000342 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 767031000343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767031000344 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031000345 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 767031000346 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767031000347 G1 box; other site 767031000348 GTP/Mg2+ binding site [chemical binding]; other site 767031000349 Switch I region; other site 767031000350 G2 box; other site 767031000351 G3 box; other site 767031000352 Switch II region; other site 767031000353 G4 box; other site 767031000354 G5 box; other site 767031000355 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767031000356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031000357 ABC transporter; Region: ABC_tran_2; pfam12848 767031000358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031000359 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 767031000360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767031000361 Walker A/P-loop; other site 767031000362 ATP binding site [chemical binding]; other site 767031000363 Q-loop/lid; other site 767031000364 ABC transporter signature motif; other site 767031000365 Walker B; other site 767031000366 D-loop; other site 767031000367 H-loop/switch region; other site 767031000368 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 767031000369 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 767031000370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 767031000371 nucleotide binding region [chemical binding]; other site 767031000372 ATP-binding site [chemical binding]; other site 767031000373 SEC-C motif; Region: SEC-C; pfam02810 767031000374 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 767031000375 putative hydrolase; Provisional; Region: PRK02113 767031000376 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767031000377 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 767031000378 FAD binding domain; Region: FAD_binding_4; pfam01565 767031000379 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767031000380 maltose O-acetyltransferase; Provisional; Region: PRK10092 767031000381 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767031000382 active site 767031000383 substrate binding site [chemical binding]; other site 767031000384 trimer interface [polypeptide binding]; other site 767031000385 CoA binding site [chemical binding]; other site 767031000386 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 767031000387 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767031000388 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767031000389 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767031000390 dimer interface [polypeptide binding]; other site 767031000391 motif 1; other site 767031000392 active site 767031000393 motif 2; other site 767031000394 motif 3; other site 767031000395 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 767031000396 homodimer interaction site [polypeptide binding]; other site 767031000397 cofactor binding site; other site 767031000398 OPT oligopeptide transporter protein; Region: OPT; pfam03169 767031000399 putative oligopeptide transporter, OPT family; Region: TIGR00733 767031000400 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 767031000401 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 767031000402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767031000403 catalytic residue [active] 767031000404 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 767031000405 Na binding site [ion binding]; other site 767031000406 pantothenate kinase; Provisional; Region: PRK13317 767031000407 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767031000408 IHF - DNA interface [nucleotide binding]; other site 767031000409 IHF dimer interface [polypeptide binding]; other site 767031000410 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 767031000411 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 767031000412 homodimer interface [polypeptide binding]; other site 767031000413 oligonucleotide binding site [chemical binding]; other site 767031000414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031000415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031000416 dimer interface [polypeptide binding]; other site 767031000417 phosphorylation site [posttranslational modification] 767031000418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031000419 ATP binding site [chemical binding]; other site 767031000420 Mg2+ binding site [ion binding]; other site 767031000421 G-X-G motif; other site 767031000422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767031000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031000424 active site 767031000425 phosphorylation site [posttranslational modification] 767031000426 intermolecular recognition site; other site 767031000427 dimerization interface [polypeptide binding]; other site 767031000428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767031000429 DNA binding site [nucleotide binding] 767031000430 L-aspartate oxidase; Provisional; Region: PRK09077 767031000431 L-aspartate oxidase; Provisional; Region: PRK06175 767031000432 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767031000433 quinolinate synthetase; Provisional; Region: PRK09375 767031000434 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 767031000435 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 767031000436 dimerization interface [polypeptide binding]; other site 767031000437 active site 767031000438 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 767031000439 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 767031000440 active site 767031000441 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 767031000442 putative catalytic site [active] 767031000443 putative metal binding site [ion binding]; other site 767031000444 putative phosphate binding site [ion binding]; other site 767031000445 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 767031000446 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 767031000447 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 767031000448 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 767031000449 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 767031000450 UbiA prenyltransferase family; Region: UbiA; pfam01040 767031000451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767031000452 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767031000453 nucleoside/Zn binding site; other site 767031000454 dimer interface [polypeptide binding]; other site 767031000455 catalytic motif [active] 767031000456 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767031000457 nucleoside/Zn binding site; other site 767031000458 dimer interface [polypeptide binding]; other site 767031000459 catalytic motif [active] 767031000460 hypothetical protein; Reviewed; Region: PRK12497 767031000461 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 767031000462 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 767031000463 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767031000464 putative nucleotide binding site [chemical binding]; other site 767031000465 uridine monophosphate binding site [chemical binding]; other site 767031000466 homohexameric interface [polypeptide binding]; other site 767031000467 glycyl-tRNA synthetase; Provisional; Region: PRK04173 767031000468 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767031000469 motif 1; other site 767031000470 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 767031000471 active site 767031000472 motif 2; other site 767031000473 motif 3; other site 767031000474 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 767031000475 anticodon binding site; other site 767031000476 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767031000477 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767031000478 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 767031000479 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 767031000480 active site 767031000481 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767031000482 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 767031000483 ligand binding site [chemical binding]; other site 767031000484 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 767031000485 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767031000486 TPP-binding site; other site 767031000487 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767031000488 PYR/PP interface [polypeptide binding]; other site 767031000489 dimer interface [polypeptide binding]; other site 767031000490 TPP binding site [chemical binding]; other site 767031000491 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767031000492 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 767031000493 TrkA-N domain; Region: TrkA_N; pfam02254 767031000494 TrkA-C domain; Region: TrkA_C; pfam02080 767031000495 TrkA-N domain; Region: TrkA_N; pfam02254 767031000496 TrkA-C domain; Region: TrkA_C; pfam02080 767031000497 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767031000498 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 767031000499 AAA domain; Region: AAA_21; pfam13304 767031000500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031000501 ABC transporter signature motif; other site 767031000502 Walker B; other site 767031000503 D-loop; other site 767031000504 H-loop/switch region; other site 767031000505 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 767031000506 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767031000507 homodimer interface [polypeptide binding]; other site 767031000508 substrate-cofactor binding pocket; other site 767031000509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031000510 catalytic residue [active] 767031000511 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767031000512 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767031000513 dimer interface [polypeptide binding]; other site 767031000514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031000515 catalytic residue [active] 767031000516 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 767031000517 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 767031000518 adenylosuccinate lyase; Provisional; Region: PRK09285 767031000519 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 767031000520 tetramer interface [polypeptide binding]; other site 767031000521 active site 767031000522 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767031000523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767031000524 RNA binding surface [nucleotide binding]; other site 767031000525 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767031000526 active site 767031000527 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767031000528 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 767031000529 putative dimer interface [polypeptide binding]; other site 767031000530 putative anticodon binding site; other site 767031000531 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767031000532 homodimer interface [polypeptide binding]; other site 767031000533 motif 1; other site 767031000534 motif 2; other site 767031000535 active site 767031000536 motif 3; other site 767031000537 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767031000538 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767031000539 dimerization interface [polypeptide binding]; other site 767031000540 DPS ferroxidase diiron center [ion binding]; other site 767031000541 ion pore; other site 767031000542 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 767031000543 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 767031000544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 767031000545 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767031000546 active site 767031000547 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767031000548 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767031000549 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 767031000550 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767031000551 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767031000552 OstA-like protein; Region: OstA_2; pfam13100 767031000553 OstA-like protein; Region: OstA; cl00844 767031000554 OstA-like protein; Region: OstA; cl00844 767031000555 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 767031000556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031000557 ATP binding site [chemical binding]; other site 767031000558 Mg2+ binding site [ion binding]; other site 767031000559 G-X-G motif; other site 767031000560 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767031000561 ATP binding site [chemical binding]; other site 767031000562 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767031000563 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 767031000564 Nnf1; Region: Nnf1; pfam03980 767031000565 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767031000566 ligand binding site [chemical binding]; other site 767031000567 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767031000568 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767031000569 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767031000570 lipoyl synthase; Provisional; Region: PRK05481 767031000571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031000572 FeS/SAM binding site; other site 767031000573 FMN-binding domain; Region: FMN_bind; pfam04205 767031000574 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767031000575 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767031000576 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767031000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031000578 putative substrate translocation pore; other site 767031000579 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 767031000580 Ligand Binding Site [chemical binding]; other site 767031000581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767031000582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767031000583 Walker A/P-loop; other site 767031000584 ATP binding site [chemical binding]; other site 767031000585 Q-loop/lid; other site 767031000586 ABC transporter signature motif; other site 767031000587 Walker B; other site 767031000588 D-loop; other site 767031000589 H-loop/switch region; other site 767031000590 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 767031000591 S1 domain; Region: S1_2; pfam13509 767031000592 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 767031000593 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 767031000594 putative ATP binding site [chemical binding]; other site 767031000595 putative substrate interface [chemical binding]; other site 767031000596 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 767031000597 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 767031000598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031000599 ATP binding site [chemical binding]; other site 767031000600 putative Mg++ binding site [ion binding]; other site 767031000601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031000602 nucleotide binding region [chemical binding]; other site 767031000603 ATP-binding site [chemical binding]; other site 767031000604 RQC domain; Region: RQC; pfam09382 767031000605 HRDC domain; Region: HRDC; pfam00570 767031000606 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767031000607 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 767031000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031000609 Walker A motif; other site 767031000610 ATP binding site [chemical binding]; other site 767031000611 Walker B motif; other site 767031000612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767031000613 Clp protease; Region: CLP_protease; pfam00574 767031000614 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767031000615 oligomer interface [polypeptide binding]; other site 767031000616 active site residues [active] 767031000617 trigger factor; Region: tig; TIGR00115 767031000618 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 767031000619 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 767031000620 Walker A/P-loop; other site 767031000621 ATP binding site [chemical binding]; other site 767031000622 Q-loop/lid; other site 767031000623 ABC transporter signature motif; other site 767031000624 Walker B; other site 767031000625 D-loop; other site 767031000626 H-loop/switch region; other site 767031000627 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 767031000628 Permease; Region: Permease; pfam02405 767031000629 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767031000630 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 767031000631 Walker A/P-loop; other site 767031000632 ATP binding site [chemical binding]; other site 767031000633 Q-loop/lid; other site 767031000634 ABC transporter signature motif; other site 767031000635 Walker B; other site 767031000636 D-loop; other site 767031000637 H-loop/switch region; other site 767031000638 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 767031000639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031000640 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 767031000641 GTP-binding protein Der; Reviewed; Region: PRK00093 767031000642 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767031000643 G1 box; other site 767031000644 GTP/Mg2+ binding site [chemical binding]; other site 767031000645 Switch I region; other site 767031000646 G2 box; other site 767031000647 Switch II region; other site 767031000648 G3 box; other site 767031000649 G4 box; other site 767031000650 G5 box; other site 767031000651 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767031000652 G1 box; other site 767031000653 GTP/Mg2+ binding site [chemical binding]; other site 767031000654 Switch I region; other site 767031000655 G2 box; other site 767031000656 G3 box; other site 767031000657 Switch II region; other site 767031000658 G4 box; other site 767031000659 G5 box; other site 767031000660 GTPase Era; Reviewed; Region: era; PRK00089 767031000661 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767031000662 G1 box; other site 767031000663 GTP/Mg2+ binding site [chemical binding]; other site 767031000664 Switch I region; other site 767031000665 G2 box; other site 767031000666 Switch II region; other site 767031000667 G3 box; other site 767031000668 G4 box; other site 767031000669 G5 box; other site 767031000670 KH domain; Region: KH_2; pfam07650 767031000671 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767031000672 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767031000673 dimer interface [polypeptide binding]; other site 767031000674 active site 767031000675 CoA binding pocket [chemical binding]; other site 767031000676 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 767031000677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031000679 ATP binding site [chemical binding]; other site 767031000680 Mg2+ binding site [ion binding]; other site 767031000681 G-X-G motif; other site 767031000682 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031000683 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031000684 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031000685 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 767031000686 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767031000687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767031000688 ligand binding site [chemical binding]; other site 767031000689 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767031000690 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 767031000691 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767031000692 NigD-like protein; Region: NigD; pfam12667 767031000693 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767031000694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031000695 active site 767031000696 hypothetical protein; Reviewed; Region: PRK00024 767031000697 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767031000698 MPN+ (JAMM) motif; other site 767031000699 Zinc-binding site [ion binding]; other site 767031000700 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 767031000701 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031000702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031000703 active site 767031000704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 767031000705 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 767031000706 Short C-terminal domain; Region: SHOCT; pfam09851 767031000707 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767031000708 dimer interface [polypeptide binding]; other site 767031000709 substrate binding site [chemical binding]; other site 767031000710 ATP binding site [chemical binding]; other site 767031000711 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031000712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031000713 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 767031000714 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 767031000715 active site 767031000716 multimer interface [polypeptide binding]; other site 767031000717 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 767031000718 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 767031000719 predicted active site [active] 767031000720 catalytic triad [active] 767031000721 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767031000722 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 767031000723 tetramer interface [polypeptide binding]; other site 767031000724 catalytic Zn binding site [ion binding]; other site 767031000725 NADP binding site [chemical binding]; other site 767031000726 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 767031000727 nucleotide binding site/active site [active] 767031000728 HIT family signature motif; other site 767031000729 catalytic residue [active] 767031000730 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767031000731 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767031000732 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767031000733 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767031000734 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767031000735 active site 767031000736 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767031000737 Peptidase family C69; Region: Peptidase_C69; cl17793 767031000738 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 767031000739 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 767031000740 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 767031000741 nucleophile elbow; other site 767031000742 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 767031000743 dihydropteroate synthase; Region: DHPS; TIGR01496 767031000744 substrate binding pocket [chemical binding]; other site 767031000745 dimer interface [polypeptide binding]; other site 767031000746 inhibitor binding site; inhibition site 767031000747 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767031000748 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767031000749 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 767031000750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 767031000751 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 767031000752 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767031000753 propionate/acetate kinase; Provisional; Region: PRK12379 767031000754 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 767031000755 putative active site [active] 767031000756 putative metal binding site [ion binding]; other site 767031000757 Domain of unknown function DUF59; Region: DUF59; cl00941 767031000758 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 767031000759 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 767031000760 active site 767031000761 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 767031000762 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 767031000763 calcium mediated ligand binding site; other site 767031000764 intermolecular salt bridges; other site 767031000765 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 767031000766 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031000767 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031000768 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031000769 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031000770 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 767031000771 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031000772 active site 767031000773 RecX family; Region: RecX; pfam02631 767031000774 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 767031000775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031000776 S-adenosylmethionine binding site [chemical binding]; other site 767031000777 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 767031000778 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 767031000779 catalytic motif [active] 767031000780 Zn binding site [ion binding]; other site 767031000781 RibD C-terminal domain; Region: RibD_C; cl17279 767031000782 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 767031000783 Transposase domain (DUF772); Region: DUF772; pfam05598 767031000784 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 767031000785 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767031000786 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 767031000787 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 767031000788 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 767031000789 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 767031000790 active site 767031000791 RNA/DNA hybrid binding site [nucleotide binding]; other site 767031000792 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 767031000793 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 767031000794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031000795 active site 767031000796 HIGH motif; other site 767031000797 nucleotide binding site [chemical binding]; other site 767031000798 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767031000799 KMSK motif region; other site 767031000800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767031000801 tRNA binding surface [nucleotide binding]; other site 767031000802 anticodon binding site; other site 767031000803 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 767031000804 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767031000805 active site 767031000806 HIGH motif; other site 767031000807 KMSKS motif; other site 767031000808 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767031000809 tRNA binding surface [nucleotide binding]; other site 767031000810 anticodon binding site; other site 767031000811 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 767031000812 dimer interface [polypeptide binding]; other site 767031000813 putative tRNA-binding site [nucleotide binding]; other site 767031000814 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767031000815 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767031000816 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767031000817 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 767031000818 Na2 binding site [ion binding]; other site 767031000819 putative substrate binding site 1 [chemical binding]; other site 767031000820 Na binding site 1 [ion binding]; other site 767031000821 putative substrate binding site 2 [chemical binding]; other site 767031000822 Predicted integral membrane protein [Function unknown]; Region: COG5652 767031000823 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 767031000824 putative active site [active] 767031000825 putative metal binding residues [ion binding]; other site 767031000826 signature motif; other site 767031000827 putative dimer interface [polypeptide binding]; other site 767031000828 putative phosphate binding site [ion binding]; other site 767031000829 peptide chain release factor 2; Validated; Region: prfB; PRK00578 767031000830 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767031000831 RF-1 domain; Region: RF-1; pfam00472 767031000832 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 767031000833 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031000834 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 767031000835 acyl-activating enzyme (AAE) consensus motif; other site 767031000836 acyl-activating enzyme (AAE) consensus motif; other site 767031000837 putative AMP binding site [chemical binding]; other site 767031000838 putative active site [active] 767031000839 putative CoA binding site [chemical binding]; other site 767031000840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 767031000841 Peptidase family M23; Region: Peptidase_M23; pfam01551 767031000842 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 767031000843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767031000844 binding surface 767031000845 TPR motif; other site 767031000846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031000847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031000848 binding surface 767031000849 TPR motif; other site 767031000850 Tetratricopeptide repeat; Region: TPR_15; pfam13429 767031000851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031000852 TPR motif; other site 767031000853 binding surface 767031000854 TPR repeat; Region: TPR_11; pfam13414 767031000855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031000856 TPR motif; other site 767031000857 binding surface 767031000858 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767031000859 trimer interface [polypeptide binding]; other site 767031000860 active site 767031000861 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 767031000862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767031000863 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 767031000864 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 767031000865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767031000866 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 767031000867 AAA domain; Region: AAA_11; pfam13086 767031000868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031000869 ATP binding site [chemical binding]; other site 767031000870 putative Mg++ binding site [ion binding]; other site 767031000871 AAA domain; Region: AAA_12; pfam13087 767031000872 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 767031000873 PB1 interaction surface [polypeptide binding]; other site 767031000874 PB1 interaction [polypeptide binding]; other site 767031000875 PB1 interaction surface [polypeptide binding]; other site 767031000876 PB1 interaction site [polypeptide binding]; other site 767031000877 PB1 interaction site [polypeptide binding]; other site 767031000878 PB1 interaction surface [polypeptide binding]; other site 767031000879 PB1 interaction surface [polypeptide binding]; other site 767031000880 AAA domain; Region: AAA_11; pfam13086 767031000881 Part of AAA domain; Region: AAA_19; pfam13245 767031000882 AAA domain; Region: AAA_30; pfam13604 767031000883 AAA domain; Region: AAA_12; pfam13087 767031000884 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 767031000885 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 767031000886 NAD binding site [chemical binding]; other site 767031000887 homotetramer interface [polypeptide binding]; other site 767031000888 homodimer interface [polypeptide binding]; other site 767031000889 substrate binding site [chemical binding]; other site 767031000890 active site 767031000891 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 767031000892 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031000893 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767031000894 active site 767031000895 DNA binding site [nucleotide binding] 767031000896 Int/Topo IB signature motif; other site 767031000897 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 767031000898 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 767031000899 Active Sites [active] 767031000900 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767031000901 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 767031000902 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 767031000903 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767031000904 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 767031000905 Divergent AAA domain; Region: AAA_4; pfam04326 767031000906 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 767031000907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767031000908 putative DNA binding site [nucleotide binding]; other site 767031000909 putative Zn2+ binding site [ion binding]; other site 767031000910 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 767031000911 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767031000912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767031000913 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 767031000914 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 767031000915 Phage associated DNA primase [General function prediction only]; Region: COG3378 767031000916 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031000917 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031000918 active site 767031000919 Int/Topo IB signature motif; other site 767031000920 DNA binding site [nucleotide binding] 767031000921 Histidine kinase; Region: His_kinase; pfam06580 767031000922 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767031000923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031000924 active site 767031000925 phosphorylation site [posttranslational modification] 767031000926 intermolecular recognition site; other site 767031000927 dimerization interface [polypeptide binding]; other site 767031000928 LytTr DNA-binding domain; Region: LytTR; smart00850 767031000929 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 767031000930 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 767031000931 Substrate binding site; other site 767031000932 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031000933 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031000934 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031000935 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 767031000936 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 767031000937 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031000938 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031000939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767031000940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767031000941 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 767031000942 dimerization interface [polypeptide binding]; other site 767031000943 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 767031000944 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767031000945 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767031000946 amphipathic channel; other site 767031000947 Asn-Pro-Ala signature motifs; other site 767031000948 glycerol kinase; Provisional; Region: glpK; PRK00047 767031000949 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767031000950 N- and C-terminal domain interface [polypeptide binding]; other site 767031000951 active site 767031000952 MgATP binding site [chemical binding]; other site 767031000953 catalytic site [active] 767031000954 metal binding site [ion binding]; metal-binding site 767031000955 glycerol binding site [chemical binding]; other site 767031000956 homotetramer interface [polypeptide binding]; other site 767031000957 homodimer interface [polypeptide binding]; other site 767031000958 FBP binding site [chemical binding]; other site 767031000959 protein IIAGlc interface [polypeptide binding]; other site 767031000960 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 767031000961 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767031000962 Cysteine-rich domain; Region: CCG; pfam02754 767031000963 Cysteine-rich domain; Region: CCG; pfam02754 767031000964 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 767031000965 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 767031000966 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 767031000967 hydroxyglutarate oxidase; Provisional; Region: PRK11728 767031000968 SPFH domain / Band 7 family; Region: Band_7; pfam01145 767031000969 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767031000970 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767031000971 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767031000972 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767031000973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767031000974 RNA binding surface [nucleotide binding]; other site 767031000975 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767031000976 active site 767031000977 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767031000978 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 767031000979 elongation factor P; Validated; Region: PRK00529 767031000980 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767031000981 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767031000982 RNA binding site [nucleotide binding]; other site 767031000983 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767031000984 RNA binding site [nucleotide binding]; other site 767031000985 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 767031000986 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767031000987 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767031000988 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 767031000989 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767031000990 FMN binding site [chemical binding]; other site 767031000991 active site 767031000992 catalytic residues [active] 767031000993 substrate binding site [chemical binding]; other site 767031000994 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 767031000995 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 767031000996 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 767031000997 Protein export membrane protein; Region: SecD_SecF; cl14618 767031000998 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 767031000999 putative catalytic site [active] 767031001000 putative metal binding site [ion binding]; other site 767031001001 putative phosphate binding site [ion binding]; other site 767031001002 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 767031001003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 767031001004 IHF - DNA interface [nucleotide binding]; other site 767031001005 IHF dimer interface [polypeptide binding]; other site 767031001006 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001007 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767031001008 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767031001009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031001010 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767031001011 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031001012 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767031001013 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031001014 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031001015 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031001016 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 767031001017 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 767031001018 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001019 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001020 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001021 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001022 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001023 SusD family; Region: SusD; pfam07980 767031001024 trehalose synthase; Region: treS_nterm; TIGR02456 767031001025 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 767031001026 active site 767031001027 catalytic site [active] 767031001028 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 767031001029 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 767031001030 catalytic residue [active] 767031001031 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 767031001032 catalytic residues [active] 767031001033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767031001034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767031001035 peroxiredoxin; Region: AhpC; TIGR03137 767031001036 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 767031001037 dimer interface [polypeptide binding]; other site 767031001038 decamer (pentamer of dimers) interface [polypeptide binding]; other site 767031001039 catalytic triad [active] 767031001040 peroxidatic and resolving cysteines [active] 767031001041 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767031001042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767031001043 Walker A/P-loop; other site 767031001044 ATP binding site [chemical binding]; other site 767031001045 Q-loop/lid; other site 767031001046 ABC transporter signature motif; other site 767031001047 Walker B; other site 767031001048 D-loop; other site 767031001049 H-loop/switch region; other site 767031001050 putative transporter; Validated; Region: PRK03818 767031001051 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767031001052 TrkA-C domain; Region: TrkA_C; pfam02080 767031001053 TrkA-C domain; Region: TrkA_C; pfam02080 767031001054 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 767031001055 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 767031001056 substrate binding site [chemical binding]; other site 767031001057 ATP binding site [chemical binding]; other site 767031001058 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767031001059 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767031001060 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767031001061 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767031001062 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 767031001063 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 767031001064 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 767031001065 active site 767031001066 ribonuclease P; Reviewed; Region: rnpA; PRK01903 767031001067 Haemolytic domain; Region: Haemolytic; pfam01809 767031001068 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 767031001069 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767031001070 active site 767031001071 HIGH motif; other site 767031001072 dimer interface [polypeptide binding]; other site 767031001073 KMSKS motif; other site 767031001074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 767031001075 RNA binding surface [nucleotide binding]; other site 767031001076 Clostripain family; Region: Peptidase_C11; pfam03415 767031001077 alpha-galactosidase; Region: PLN02808; cl17638 767031001078 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 767031001079 DNA binding site [nucleotide binding] 767031001080 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767031001081 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767031001082 active site 767031001083 Int/Topo IB signature motif; other site 767031001084 Dehydroquinase class II; Region: DHquinase_II; pfam01220 767031001085 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 767031001086 trimer interface [polypeptide binding]; other site 767031001087 active site 767031001088 dimer interface [polypeptide binding]; other site 767031001089 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 767031001090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031001091 S-adenosylmethionine binding site [chemical binding]; other site 767031001092 Ribosome-binding factor A; Region: RBFA; pfam02033 767031001093 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 767031001094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767031001095 FtsX-like permease family; Region: FtsX; pfam02687 767031001096 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 767031001097 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 767031001098 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031001099 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 767031001100 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767031001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031001102 Walker A motif; other site 767031001103 ATP binding site [chemical binding]; other site 767031001104 Walker B motif; other site 767031001105 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 767031001106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031001107 ABC transporter signature motif; other site 767031001108 DDE superfamily endonuclease; Region: DDE_5; cl17874 767031001109 Ribosome-binding factor A; Region: RBFA; pfam02033 767031001110 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 767031001111 FtsX-like permease family; Region: FtsX; pfam02687 767031001112 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 767031001113 Fic/DOC family; Region: Fic; pfam02661 767031001114 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 767031001115 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 767031001116 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 767031001117 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 767031001118 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 767031001119 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 767031001120 putative homodimer interface [polypeptide binding]; other site 767031001121 putative active site pocket [active] 767031001122 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 767031001123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767031001124 Glycogen synthase; Region: Glycogen_syn; pfam05693 767031001125 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 767031001126 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031001127 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 767031001128 acyl-activating enzyme (AAE) consensus motif; other site 767031001129 AMP binding site [chemical binding]; other site 767031001130 active site 767031001131 CoA binding site [chemical binding]; other site 767031001132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767031001133 non-specific DNA binding site [nucleotide binding]; other site 767031001134 salt bridge; other site 767031001135 sequence-specific DNA binding site [nucleotide binding]; other site 767031001136 Cupin domain; Region: Cupin_2; pfam07883 767031001137 PspC domain; Region: PspC; pfam04024 767031001138 Arginine repressor [Transcription]; Region: ArgR; COG1438 767031001139 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767031001140 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767031001141 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001142 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031001143 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 767031001144 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 767031001145 active site 767031001146 substrate-binding site [chemical binding]; other site 767031001147 metal-binding site [ion binding] 767031001148 ATP binding site [chemical binding]; other site 767031001149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031001150 active site 767031001151 Histidine kinase; Region: His_kinase; pfam06580 767031001152 para-aminobenzoate synthase component I; Validated; Region: PRK07093 767031001153 hypothetical protein; Provisional; Region: PRK07101 767031001154 substrate-cofactor binding pocket; other site 767031001155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031001156 catalytic residue [active] 767031001157 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 767031001158 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 767031001159 putative active site [active] 767031001160 putative NTP binding site [chemical binding]; other site 767031001161 putative nucleic acid binding site [nucleotide binding]; other site 767031001162 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 767031001163 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 767031001164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031001165 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767031001166 Active site serine [active] 767031001167 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767031001168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031001169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031001170 DNA binding residues [nucleotide binding] 767031001171 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001173 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031001174 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767031001175 MutS domain I; Region: MutS_I; pfam01624 767031001176 MutS domain II; Region: MutS_II; pfam05188 767031001177 MutS domain III; Region: MutS_III; pfam05192 767031001178 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767031001179 Walker A/P-loop; other site 767031001180 ATP binding site [chemical binding]; other site 767031001181 Q-loop/lid; other site 767031001182 ABC transporter signature motif; other site 767031001183 Walker B; other site 767031001184 D-loop; other site 767031001185 H-loop/switch region; other site 767031001186 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 767031001187 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 767031001188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767031001189 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 767031001190 putative active site [active] 767031001191 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 767031001192 acyl carrier protein; Provisional; Region: acpP; PRK00982 767031001193 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 767031001194 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767031001195 dimer interface [polypeptide binding]; other site 767031001196 active site 767031001197 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 767031001198 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767031001199 dimerization interface [polypeptide binding]; other site 767031001200 active site 767031001201 metal binding site [ion binding]; metal-binding site 767031001202 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767031001203 dsRNA binding site [nucleotide binding]; other site 767031001204 GTP-binding protein YchF; Reviewed; Region: PRK09601 767031001205 YchF GTPase; Region: YchF; cd01900 767031001206 G1 box; other site 767031001207 GTP/Mg2+ binding site [chemical binding]; other site 767031001208 Switch I region; other site 767031001209 G2 box; other site 767031001210 Switch II region; other site 767031001211 G3 box; other site 767031001212 G4 box; other site 767031001213 G5 box; other site 767031001214 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767031001215 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 767031001216 hypothetical protein; Provisional; Region: PRK02877 767031001217 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767031001218 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767031001219 active site 767031001220 HIGH motif; other site 767031001221 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767031001222 KMSKS motif; other site 767031001223 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767031001224 tRNA binding surface [nucleotide binding]; other site 767031001225 anticodon binding site; other site 767031001226 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 767031001227 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767031001228 Walker A/P-loop; other site 767031001229 ATP binding site [chemical binding]; other site 767031001230 Q-loop/lid; other site 767031001231 ABC transporter signature motif; other site 767031001232 Walker B; other site 767031001233 D-loop; other site 767031001234 H-loop/switch region; other site 767031001235 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 767031001236 NosL; Region: NosL; cl01769 767031001237 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 767031001238 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 767031001239 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767031001240 LytTr DNA-binding domain; Region: LytTR; smart00850 767031001241 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 767031001242 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 767031001243 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 767031001244 AIR carboxylase; Region: AIRC; pfam00731 767031001245 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 767031001246 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 767031001247 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 767031001248 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 767031001249 Peptidase family U32; Region: Peptidase_U32; pfam01136 767031001250 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 767031001251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767031001252 Sulfatase; Region: Sulfatase; cl17466 767031001253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031001254 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767031001255 putative ADP-binding pocket [chemical binding]; other site 767031001256 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 767031001257 putative metal binding site; other site 767031001258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031001259 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767031001260 putative ADP-binding pocket [chemical binding]; other site 767031001261 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 767031001262 active site 767031001263 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 767031001264 active site 767031001265 GtrA-like protein; Region: GtrA; pfam04138 767031001266 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767031001267 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767031001268 Ligand binding site; other site 767031001269 Putative Catalytic site; other site 767031001270 DXD motif; other site 767031001271 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 767031001272 putative active site [active] 767031001273 putative catalytic site [active] 767031001274 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 767031001275 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767031001276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031001277 FeS/SAM binding site; other site 767031001278 TRAM domain; Region: TRAM; pfam01938 767031001279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767031001280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031001281 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 767031001282 Walker A/P-loop; other site 767031001283 ATP binding site [chemical binding]; other site 767031001284 Q-loop/lid; other site 767031001285 ABC transporter signature motif; other site 767031001286 Walker B; other site 767031001287 D-loop; other site 767031001288 H-loop/switch region; other site 767031001289 Sulfatase; Region: Sulfatase; pfam00884 767031001290 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767031001291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 767031001292 putative acyl-acceptor binding pocket; other site 767031001293 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001294 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031001295 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001296 AAA ATPase domain; Region: AAA_16; pfam13191 767031001297 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 767031001298 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 767031001299 active site 767031001300 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767031001301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031001302 NAD(P) binding site [chemical binding]; other site 767031001303 active site 767031001304 ribonuclease R; Region: RNase_R; TIGR02063 767031001305 RNB domain; Region: RNB; pfam00773 767031001306 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 767031001307 RNA binding site [nucleotide binding]; other site 767031001308 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 767031001309 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 767031001310 TPP-binding site [chemical binding]; other site 767031001311 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 767031001312 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767031001313 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767031001314 dimer interface [polypeptide binding]; other site 767031001315 PYR/PP interface [polypeptide binding]; other site 767031001316 TPP binding site [chemical binding]; other site 767031001317 substrate binding site [chemical binding]; other site 767031001318 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 767031001319 active site 767031001320 catalytic residues [active] 767031001321 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 767031001322 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 767031001323 Sulfatase; Region: Sulfatase; cl17466 767031001324 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 767031001325 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 767031001326 dimer interface [polypeptide binding]; other site 767031001327 putative radical transfer pathway; other site 767031001328 diiron center [ion binding]; other site 767031001329 tyrosyl radical; other site 767031001330 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364 767031001331 ATP cone domain; Region: ATP-cone; pfam03477 767031001332 Class I ribonucleotide reductase; Region: RNR_I; cd01679 767031001333 active site 767031001334 dimer interface [polypeptide binding]; other site 767031001335 catalytic residues [active] 767031001336 effector binding site; other site 767031001337 R2 peptide binding site; other site 767031001338 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 767031001339 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 767031001340 active site 767031001341 catalytic motif [active] 767031001342 Zn binding site [ion binding]; other site 767031001343 glutamate racemase; Provisional; Region: PRK00865 767031001344 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 767031001345 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 767031001346 periplasmic chaperone; Provisional; Region: PRK10780 767031001347 periplasmic chaperone; Provisional; Region: PRK10780 767031001348 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 767031001349 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 767031001350 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 767031001351 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 767031001352 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 767031001353 Surface antigen; Region: Bac_surface_Ag; pfam01103 767031001354 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838 767031001355 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 767031001356 catalytic residue [active] 767031001357 putative FPP diphosphate binding site; other site 767031001358 putative FPP binding hydrophobic cleft; other site 767031001359 dimer interface [polypeptide binding]; other site 767031001360 putative IPP diphosphate binding site; other site 767031001361 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 767031001362 glycyl-tRNA synthetase; Provisional; Region: PRK14908 767031001363 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 767031001364 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767031001365 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767031001366 PhoU domain; Region: PhoU; pfam01895 767031001367 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767031001368 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 767031001369 active site 767031001370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767031001371 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767031001372 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001373 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031001374 GH3 auxin-responsive promoter; Region: GH3; pfam03321 767031001375 Bacterial Ig-like domain; Region: Big_5; pfam13205 767031001376 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 767031001377 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 767031001378 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767031001379 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 767031001380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031001381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031001382 active site 767031001383 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767031001384 active site 767031001385 dimerization interface [polypeptide binding]; other site 767031001386 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767031001387 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767031001388 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767031001389 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767031001390 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 767031001391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031001392 active site 767031001393 HIGH motif; other site 767031001394 nucleotide binding site [chemical binding]; other site 767031001395 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767031001396 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031001397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031001398 active site 767031001399 KMSKS motif; other site 767031001400 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767031001401 tRNA binding surface [nucleotide binding]; other site 767031001402 DNA polymerase I; Provisional; Region: PRK05755 767031001403 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767031001404 active site 767031001405 metal binding site 1 [ion binding]; metal-binding site 767031001406 putative 5' ssDNA interaction site; other site 767031001407 metal binding site 3; metal-binding site 767031001408 metal binding site 2 [ion binding]; metal-binding site 767031001409 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767031001410 putative DNA binding site [nucleotide binding]; other site 767031001411 putative metal binding site [ion binding]; other site 767031001412 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 767031001413 active site 767031001414 catalytic site [active] 767031001415 substrate binding site [chemical binding]; other site 767031001416 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767031001417 active site 767031001418 DNA binding site [nucleotide binding] 767031001419 catalytic site [active] 767031001420 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767031001421 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767031001422 substrate binding pocket [chemical binding]; other site 767031001423 chain length determination region; other site 767031001424 substrate-Mg2+ binding site; other site 767031001425 catalytic residues [active] 767031001426 aspartate-rich region 1; other site 767031001427 active site lid residues [active] 767031001428 aspartate-rich region 2; other site 767031001429 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 767031001430 intersubunit interface [polypeptide binding]; other site 767031001431 active site 767031001432 catalytic residue [active] 767031001433 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 767031001434 homodimer interface [polypeptide binding]; other site 767031001435 metal binding site [ion binding]; metal-binding site 767031001436 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 767031001437 putative active site [active] 767031001438 dimerization interface [polypeptide binding]; other site 767031001439 putative tRNAtyr binding site [nucleotide binding]; other site 767031001440 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767031001441 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767031001442 GIY-YIG motif/motif A; other site 767031001443 active site 767031001444 catalytic site [active] 767031001445 putative DNA binding site [nucleotide binding]; other site 767031001446 metal binding site [ion binding]; metal-binding site 767031001447 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767031001448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031001449 active site 767031001450 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767031001451 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 767031001452 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767031001453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031001454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767031001455 putative substrate translocation pore; other site 767031001456 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001457 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 767031001458 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 767031001459 N-terminal plug; other site 767031001460 ligand-binding site [chemical binding]; other site 767031001461 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 767031001462 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 767031001463 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767031001464 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 767031001465 putative active site [active] 767031001466 putative catalytic site [active] 767031001467 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 767031001468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031001469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031001470 dimer interface [polypeptide binding]; other site 767031001471 phosphorylation site [posttranslational modification] 767031001472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031001473 ATP binding site [chemical binding]; other site 767031001474 Mg2+ binding site [ion binding]; other site 767031001475 G-X-G motif; other site 767031001476 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 767031001477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031001478 active site 767031001479 phosphorylation site [posttranslational modification] 767031001480 intermolecular recognition site; other site 767031001481 dimerization interface [polypeptide binding]; other site 767031001482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767031001483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031001484 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031001485 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031001486 SusD family; Region: SusD; pfam07980 767031001487 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001488 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001489 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001490 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001491 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 767031001492 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 767031001493 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 767031001494 putative Iron-sulfur protein interface [polypeptide binding]; other site 767031001495 proximal heme binding site [chemical binding]; other site 767031001496 distal heme binding site [chemical binding]; other site 767031001497 putative dimer interface [polypeptide binding]; other site 767031001498 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 767031001499 L-aspartate oxidase; Provisional; Region: PRK06175 767031001500 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767031001501 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 767031001502 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 767031001503 GLPGLI family protein; Region: GLPGLI; TIGR01200 767031001504 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767031001505 active site 767031001506 substrate binding site [chemical binding]; other site 767031001507 ATP binding site [chemical binding]; other site 767031001508 Protein kinase domain; Region: Pkinase; pfam00069 767031001509 activation loop (A-loop); other site 767031001510 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767031001511 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767031001512 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767031001513 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 767031001514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767031001515 Catalytic site [active] 767031001516 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767031001517 WbqC-like protein family; Region: WbqC; pfam08889 767031001518 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767031001519 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031001520 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 767031001521 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681 767031001522 nudix motif; other site 767031001523 DNA topoisomerase I; Validated; Region: PRK06599 767031001524 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767031001525 active site 767031001526 interdomain interaction site; other site 767031001527 putative metal-binding site [ion binding]; other site 767031001528 nucleotide binding site [chemical binding]; other site 767031001529 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767031001530 domain I; other site 767031001531 DNA binding groove [nucleotide binding] 767031001532 phosphate binding site [ion binding]; other site 767031001533 domain II; other site 767031001534 domain III; other site 767031001535 nucleotide binding site [chemical binding]; other site 767031001536 catalytic site [active] 767031001537 domain IV; other site 767031001538 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 767031001539 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 767031001540 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 767031001541 Shikimate kinase; Region: SKI; pfam01202 767031001542 ADP binding site [chemical binding]; other site 767031001543 magnesium binding site [ion binding]; other site 767031001544 putative shikimate binding site; other site 767031001545 arginine decarboxylase; Provisional; Region: PRK05354 767031001546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 767031001547 dimer interface [polypeptide binding]; other site 767031001548 active site 767031001549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767031001550 catalytic residues [active] 767031001551 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 767031001552 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767031001553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031001554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031001555 DNA binding residues [nucleotide binding] 767031001556 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001557 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001558 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 767031001559 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 767031001560 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767031001561 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767031001562 Peptidase S46; Region: Peptidase_S46; pfam10459 767031001563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767031001564 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767031001565 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767031001566 C-terminal peptidase (prc); Region: prc; TIGR00225 767031001567 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767031001568 protein binding site [polypeptide binding]; other site 767031001569 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767031001570 Catalytic dyad [active] 767031001571 GxxExxY protein; Region: GxxExxY; TIGR04256 767031001572 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 767031001573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031001574 ATP binding site [chemical binding]; other site 767031001575 Mg2+ binding site [ion binding]; other site 767031001576 G-X-G motif; other site 767031001577 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 767031001578 ATP binding site [chemical binding]; other site 767031001579 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 767031001580 active site 767031001581 putative metal-binding site [ion binding]; other site 767031001582 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767031001583 Endonuclease I; Region: Endonuclease_1; cl01003 767031001584 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767031001585 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 767031001586 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 767031001587 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767031001588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031001589 active site 767031001590 nucleotide binding site [chemical binding]; other site 767031001591 HIGH motif; other site 767031001592 KMSKS motif; other site 767031001593 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 767031001594 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767031001595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031001596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031001597 DNA binding residues [nucleotide binding] 767031001598 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 767031001599 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 767031001600 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 767031001601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031001602 Walker A motif; other site 767031001603 ATP binding site [chemical binding]; other site 767031001604 Walker B motif; other site 767031001605 arginine finger; other site 767031001606 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767031001607 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767031001608 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767031001609 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767031001610 M28 Zn-Peptidases; Region: M28_like_6; cd08656 767031001611 Peptidase family M28; Region: Peptidase_M28; pfam04389 767031001612 metal binding site [ion binding]; metal-binding site 767031001613 Peptidase C26; Region: Peptidase_C26; pfam07722 767031001614 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767031001615 conserved cys residue [active] 767031001616 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767031001617 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 767031001618 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 767031001619 active site 767031001620 dimer interface [polypeptide binding]; other site 767031001621 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 767031001622 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 767031001623 putative DNA binding site [nucleotide binding]; other site 767031001624 putative Zn2+ binding site [ion binding]; other site 767031001625 AsnC family; Region: AsnC_trans_reg; pfam01037 767031001626 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 767031001627 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 767031001628 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767031001629 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 767031001630 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 767031001631 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767031001632 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 767031001633 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 767031001634 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767031001635 NAD-dependent deacetylase; Provisional; Region: PRK00481 767031001636 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 767031001637 NAD+ binding site [chemical binding]; other site 767031001638 substrate binding site [chemical binding]; other site 767031001639 Zn binding site [ion binding]; other site 767031001640 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 767031001641 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 767031001642 RNase E interface [polypeptide binding]; other site 767031001643 trimer interface [polypeptide binding]; other site 767031001644 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 767031001645 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 767031001646 RNase E interface [polypeptide binding]; other site 767031001647 trimer interface [polypeptide binding]; other site 767031001648 active site 767031001649 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 767031001650 putative nucleic acid binding region [nucleotide binding]; other site 767031001651 G-X-X-G motif; other site 767031001652 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 767031001653 RNA binding site [nucleotide binding]; other site 767031001654 domain interface; other site 767031001655 DNA protecting protein DprA; Region: dprA; TIGR00732 767031001656 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 767031001657 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767031001658 active site 767031001659 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 767031001660 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001661 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001662 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767031001663 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767031001664 ATP binding site [chemical binding]; other site 767031001665 Mg++ binding site [ion binding]; other site 767031001666 motif III; other site 767031001667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031001668 nucleotide binding region [chemical binding]; other site 767031001669 ATP-binding site [chemical binding]; other site 767031001670 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 767031001671 RNA binding site [nucleotide binding]; other site 767031001672 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 767031001673 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767031001674 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 767031001675 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767031001676 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767031001677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031001678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031001679 dimer interface [polypeptide binding]; other site 767031001680 phosphorylation site [posttranslational modification] 767031001681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031001682 ATP binding site [chemical binding]; other site 767031001683 Mg2+ binding site [ion binding]; other site 767031001684 G-X-G motif; other site 767031001685 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 767031001686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031001687 active site 767031001688 phosphorylation site [posttranslational modification] 767031001689 intermolecular recognition site; other site 767031001690 dimerization interface [polypeptide binding]; other site 767031001691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767031001692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031001693 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001694 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001695 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001696 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001697 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031001698 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001699 SusD family; Region: SusD; pfam07980 767031001700 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 767031001701 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 767031001702 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767031001703 substrate binding [chemical binding]; other site 767031001704 active site 767031001705 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767031001706 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767031001707 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767031001708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031001709 dimer interface [polypeptide binding]; other site 767031001710 phosphorylation site [posttranslational modification] 767031001711 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 767031001712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031001713 active site 767031001714 phosphorylation site [posttranslational modification] 767031001715 intermolecular recognition site; other site 767031001716 dimerization interface [polypeptide binding]; other site 767031001717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031001718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767031001719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031001720 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001721 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001722 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001723 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001724 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 767031001725 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031001726 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001727 SusD family; Region: SusD; pfam07980 767031001728 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 767031001729 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 767031001730 active site 767031001731 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 767031001732 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767031001733 substrate binding [chemical binding]; other site 767031001734 active site 767031001735 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767031001736 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 767031001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031001738 putative substrate translocation pore; other site 767031001739 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767031001740 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 767031001741 putative substrate binding site [chemical binding]; other site 767031001742 putative ATP binding site [chemical binding]; other site 767031001743 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 767031001744 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 767031001745 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 767031001746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767031001747 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767031001748 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 767031001749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767031001750 putative substrate binding site [chemical binding]; other site 767031001751 putative ATP binding site [chemical binding]; other site 767031001752 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031001753 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767031001754 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031001755 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 767031001756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767031001757 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 767031001758 homotrimer interaction site [polypeptide binding]; other site 767031001759 zinc binding site [ion binding]; other site 767031001760 CDP-binding sites; other site 767031001761 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 767031001762 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 767031001763 active site 767031001764 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031001765 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 767031001766 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 767031001767 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 767031001768 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767031001769 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031001770 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 767031001771 Uncharacterized conserved protein [Function unknown]; Region: COG1479 767031001772 Protein of unknown function DUF262; Region: DUF262; pfam03235 767031001773 Uncharacterized conserved protein [Function unknown]; Region: COG1479 767031001774 Protein of unknown function DUF262; Region: DUF262; pfam03235 767031001775 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031001776 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 767031001777 N-terminal plug; other site 767031001778 ligand-binding site [chemical binding]; other site 767031001779 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767031001780 23S rRNA interface [nucleotide binding]; other site 767031001781 L3 interface [polypeptide binding]; other site 767031001782 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767031001783 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767031001784 rRNA interaction site [nucleotide binding]; other site 767031001785 S8 interaction site; other site 767031001786 putative laminin-1 binding site; other site 767031001787 elongation factor Ts; Provisional; Region: tsf; PRK09377 767031001788 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 767031001789 Elongation factor TS; Region: EF_TS; pfam00889 767031001790 Elongation factor TS; Region: EF_TS; pfam00889 767031001791 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001792 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001793 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001794 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001795 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001796 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001797 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767031001798 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767031001799 active site 767031001800 metal binding site [ion binding]; metal-binding site 767031001801 homotetramer interface [polypeptide binding]; other site 767031001802 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 767031001803 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767031001804 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767031001805 Peptidase family M23; Region: Peptidase_M23; pfam01551 767031001806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767031001807 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767031001808 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 767031001809 generic binding surface II; other site 767031001810 ssDNA binding site; other site 767031001811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031001812 ATP binding site [chemical binding]; other site 767031001813 putative Mg++ binding site [ion binding]; other site 767031001814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031001815 nucleotide binding region [chemical binding]; other site 767031001816 ATP-binding site [chemical binding]; other site 767031001817 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 767031001818 substrate binding site; other site 767031001819 dimer interface; other site 767031001820 DJ-1 family protein; Region: not_thiJ; TIGR01383 767031001821 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 767031001822 conserved cys residue [active] 767031001823 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 767031001824 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 767031001825 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767031001826 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031001827 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767031001828 Walker A/P-loop; other site 767031001829 ATP binding site [chemical binding]; other site 767031001830 Q-loop/lid; other site 767031001831 ABC transporter signature motif; other site 767031001832 Walker B; other site 767031001833 D-loop; other site 767031001834 H-loop/switch region; other site 767031001835 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 767031001836 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031001837 catalytic residues [active] 767031001838 AAA domain; Region: AAA_14; pfam13173 767031001839 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 767031001840 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 767031001841 Sulfatase; Region: Sulfatase; cl17466 767031001842 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 767031001843 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 767031001844 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767031001845 Ca binding site [ion binding]; other site 767031001846 active site 767031001847 homodimer interface [polypeptide binding]; other site 767031001848 catalytic site [active] 767031001849 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 767031001850 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 767031001851 pullulanase, type I; Region: pulA_typeI; TIGR02104 767031001852 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 767031001853 Ca binding site [ion binding]; other site 767031001854 active site 767031001855 catalytic site [active] 767031001856 4-alpha-glucanotransferase; Region: PLN02950 767031001857 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 767031001858 starch-binding site 2 [chemical binding]; other site 767031001859 starch-binding site 1 [chemical binding]; other site 767031001860 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 767031001861 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 767031001862 active site 767031001863 Ca binding site [ion binding]; other site 767031001864 catalytic site [active] 767031001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031001866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767031001867 putative substrate translocation pore; other site 767031001868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767031001869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767031001870 DNA binding site [nucleotide binding] 767031001871 domain linker motif; other site 767031001872 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767031001873 dimerization interface [polypeptide binding]; other site 767031001874 ligand binding site [chemical binding]; other site 767031001875 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001876 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001877 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 767031001878 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 767031001879 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031001880 SusE outer membrane protein; Region: SusE; pfam14292 767031001881 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 767031001882 starch binding site [chemical binding]; other site 767031001883 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 767031001884 starch binding site [chemical binding]; other site 767031001885 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 767031001886 starch binding site [chemical binding]; other site 767031001887 alpha-amylase; Region: PLN02361 767031001888 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 767031001889 active site 767031001890 Ca binding site [ion binding]; other site 767031001891 catalytic site [active] 767031001892 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 767031001893 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 767031001894 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 767031001895 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 767031001896 Aspartase; Region: Aspartase; cd01357 767031001897 active sites [active] 767031001898 tetramer interface [polypeptide binding]; other site 767031001899 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767031001900 RNA/DNA hybrid binding site [nucleotide binding]; other site 767031001901 active site 767031001902 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767031001903 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767031001904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767031001905 catalytic residue [active] 767031001906 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 767031001907 FeS assembly protein SufD; Region: sufD; TIGR01981 767031001908 FeS assembly ATPase SufC; Region: sufC; TIGR01978 767031001909 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 767031001910 Walker A/P-loop; other site 767031001911 ATP binding site [chemical binding]; other site 767031001912 Q-loop/lid; other site 767031001913 ABC transporter signature motif; other site 767031001914 Walker B; other site 767031001915 D-loop; other site 767031001916 H-loop/switch region; other site 767031001917 putative ABC transporter; Region: ycf24; CHL00085 767031001918 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 767031001919 translation initiation factor IF-2; Region: IF-2; TIGR00487 767031001920 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767031001921 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767031001922 G1 box; other site 767031001923 putative GEF interaction site [polypeptide binding]; other site 767031001924 GTP/Mg2+ binding site [chemical binding]; other site 767031001925 Switch I region; other site 767031001926 G2 box; other site 767031001927 G3 box; other site 767031001928 Switch II region; other site 767031001929 G4 box; other site 767031001930 G5 box; other site 767031001931 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767031001932 Translation-initiation factor 2; Region: IF-2; pfam11987 767031001933 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767031001934 transcription termination factor NusA; Region: NusA; TIGR01953 767031001935 NusA N-terminal domain; Region: NusA_N; pfam08529 767031001936 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767031001937 RNA binding site [nucleotide binding]; other site 767031001938 homodimer interface [polypeptide binding]; other site 767031001939 NusA-like KH domain; Region: KH_5; pfam13184 767031001940 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767031001941 G-X-X-G motif; other site 767031001942 Sm and related proteins; Region: Sm_like; cl00259 767031001943 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767031001944 C-terminal peptidase (prc); Region: prc; TIGR00225 767031001945 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767031001946 protein binding site [polypeptide binding]; other site 767031001947 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767031001948 Catalytic dyad [active] 767031001949 Uncharacterized conserved protein [Function unknown]; Region: COG4938 767031001950 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 767031001951 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 767031001952 putative active site [active] 767031001953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031001954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031001955 Walker A/P-loop; other site 767031001956 ATP binding site [chemical binding]; other site 767031001957 Q-loop/lid; other site 767031001958 ABC transporter signature motif; other site 767031001959 Walker B; other site 767031001960 D-loop; other site 767031001961 H-loop/switch region; other site 767031001962 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 767031001963 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 767031001964 non-heme iron binding site [ion binding]; other site 767031001965 dimer interface [polypeptide binding]; other site 767031001966 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 767031001967 non-heme iron binding site [ion binding]; other site 767031001968 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 767031001969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031001970 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 767031001971 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 767031001972 metal-binding site 767031001973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031001974 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031001975 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031001976 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031001977 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031001978 SusD family; Region: SusD; pfam07980 767031001979 Predicted transcriptional regulator [Transcription]; Region: COG2378 767031001980 WYL domain; Region: WYL; pfam13280 767031001981 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 767031001982 active site 767031001983 catalytic triad [active] 767031001984 oxyanion hole [active] 767031001985 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031001986 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 767031001987 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 767031001988 phosphoglyceromutase; Provisional; Region: PRK05434 767031001989 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767031001990 ligand binding site [chemical binding]; other site 767031001991 active site 767031001992 UGI interface [polypeptide binding]; other site 767031001993 catalytic site [active] 767031001994 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767031001995 ligand binding site [chemical binding]; other site 767031001996 active site 767031001997 UGI interface [polypeptide binding]; other site 767031001998 catalytic site [active] 767031001999 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 767031002000 Cupin domain; Region: Cupin_2; cl17218 767031002001 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031002002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031002003 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767031002004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031002005 ATP binding site [chemical binding]; other site 767031002006 Mg2+ binding site [ion binding]; other site 767031002007 G-X-G motif; other site 767031002008 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767031002009 anchoring element; other site 767031002010 dimer interface [polypeptide binding]; other site 767031002011 ATP binding site [chemical binding]; other site 767031002012 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767031002013 active site 767031002014 putative metal-binding site [ion binding]; other site 767031002015 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767031002016 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767031002017 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 767031002018 Recombination protein O N terminal; Region: RecO_N; pfam11967 767031002019 Recombination protein O C terminal; Region: RecO_C; pfam02565 767031002020 Predicted membrane protein [Function unknown]; Region: COG2855 767031002021 cell division protein FtsZ; Validated; Region: PRK09330 767031002022 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767031002023 nucleotide binding site [chemical binding]; other site 767031002024 SulA interaction site; other site 767031002025 cell division protein FtsA; Region: ftsA; TIGR01174 767031002026 Cell division protein FtsA; Region: FtsA; smart00842 767031002027 Cell division protein FtsA; Region: FtsA; pfam14450 767031002028 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767031002029 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031002030 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767031002031 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767031002032 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767031002033 homodimer interface [polypeptide binding]; other site 767031002034 active site 767031002035 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 767031002036 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 767031002037 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 767031002038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031002039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767031002040 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767031002041 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767031002042 Mg++ binding site [ion binding]; other site 767031002043 putative catalytic motif [active] 767031002044 putative substrate binding site [chemical binding]; other site 767031002045 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767031002046 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767031002047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031002048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767031002049 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767031002050 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767031002051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767031002052 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767031002053 two component system sensor kinase SsrA; Provisional; Region: PRK15347 767031002054 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767031002055 MraW methylase family; Region: Methyltransf_5; cl17771 767031002056 cell division protein MraZ; Reviewed; Region: PRK00326 767031002057 MraZ protein; Region: MraZ; pfam02381 767031002058 MraZ protein; Region: MraZ; pfam02381 767031002059 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767031002060 putative acyl-acceptor binding pocket; other site 767031002061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 767031002062 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 767031002063 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 767031002064 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767031002065 AAA domain; Region: AAA_22; pfam13401 767031002066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031002067 Walker A motif; other site 767031002068 ATP binding site [chemical binding]; other site 767031002069 Walker B motif; other site 767031002070 Family description; Region: UvrD_C_2; pfam13538 767031002071 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 767031002072 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 767031002073 catalytic triad [active] 767031002074 Abi-like protein; Region: Abi_2; pfam07751 767031002075 LicD family; Region: LicD; pfam04991 767031002076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031002077 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 767031002078 NAD(P) binding site [chemical binding]; other site 767031002079 active site 767031002080 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 767031002081 substrate binding site; other site 767031002082 dimer interface; other site 767031002083 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031002084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031002085 active site 767031002086 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 767031002087 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767031002088 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767031002089 active site 767031002090 Zn binding site [ion binding]; other site 767031002091 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767031002092 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 767031002093 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767031002094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031002095 active site 767031002096 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 767031002097 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 767031002098 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 767031002099 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767031002100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767031002101 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 767031002102 Sulfatase; Region: Sulfatase; cl17466 767031002103 CotH protein; Region: CotH; pfam08757 767031002104 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031002105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031002106 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 767031002107 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767031002108 active site 767031002109 (T/H)XGH motif; other site 767031002110 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767031002111 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767031002112 catalytic site [active] 767031002113 G-X2-G-X-G-K; other site 767031002114 hypothetical protein; Provisional; Region: PRK11820 767031002115 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 767031002116 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 767031002117 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767031002118 Glycoprotease family; Region: Peptidase_M22; pfam00814 767031002119 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 767031002120 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767031002121 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767031002122 hinge; other site 767031002123 active site 767031002124 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767031002125 RimM N-terminal domain; Region: RimM; pfam01782 767031002126 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 767031002127 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 767031002128 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 767031002129 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 767031002130 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767031002131 RIP metalloprotease RseP; Region: TIGR00054 767031002132 active site 767031002133 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767031002134 protein binding site [polypeptide binding]; other site 767031002135 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767031002136 putative substrate binding region [chemical binding]; other site 767031002137 Chromate transporter; Region: Chromate_transp; pfam02417 767031002138 Chromate transporter; Region: Chromate_transp; pfam02417 767031002139 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 767031002140 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767031002141 dimerization interface [polypeptide binding]; other site 767031002142 ATP binding site [chemical binding]; other site 767031002143 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767031002144 dimerization interface [polypeptide binding]; other site 767031002145 ATP binding site [chemical binding]; other site 767031002146 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767031002147 putative active site [active] 767031002148 catalytic triad [active] 767031002149 Peptidase C10 family; Region: Peptidase_C10; pfam01640 767031002150 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031002151 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 767031002152 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 767031002153 substrate-cofactor binding pocket; other site 767031002154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031002155 catalytic residue [active] 767031002156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767031002157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031002158 NAD(P) binding site [chemical binding]; other site 767031002159 active site 767031002160 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 767031002161 Putative esterase; Region: Esterase; pfam00756 767031002162 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 767031002163 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 767031002164 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 767031002165 homotrimer interaction site [polypeptide binding]; other site 767031002166 putative active site [active] 767031002167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 767031002168 homotrimer interaction site [polypeptide binding]; other site 767031002169 putative active site [active] 767031002170 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 767031002171 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 767031002172 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767031002173 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031002174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031002175 active site 767031002176 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 767031002177 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 767031002178 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 767031002179 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 767031002180 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 767031002181 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 767031002182 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 767031002183 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 767031002184 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 767031002185 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 767031002186 GldM N-terminal domain; Region: GldM_N; pfam12081 767031002187 GldM C-terminal domain; Region: GldM_C; pfam12080 767031002188 gliding motility associated protien GldN; Region: GldN; TIGR03523 767031002189 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031002190 primosome assembly protein PriA; Validated; Region: PRK05580 767031002191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031002192 ATP binding site [chemical binding]; other site 767031002193 putative Mg++ binding site [ion binding]; other site 767031002194 helicase superfamily c-terminal domain; Region: HELICc; smart00490 767031002195 ATP-binding site [chemical binding]; other site 767031002196 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 767031002197 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 767031002198 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 767031002199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031002200 Zn2+ binding site [ion binding]; other site 767031002201 Mg2+ binding site [ion binding]; other site 767031002202 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767031002203 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767031002204 HIGH motif; other site 767031002205 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767031002206 active site 767031002207 KMSKS motif; other site 767031002208 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 767031002209 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 767031002210 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767031002211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767031002212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767031002213 active site 767031002214 HIGH motif; other site 767031002215 dimer interface [polypeptide binding]; other site 767031002216 KMSKS motif; other site 767031002217 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 767031002218 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 767031002219 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 767031002220 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 767031002221 NAD(P) binding site [chemical binding]; other site 767031002222 LDH/MDH dimer interface [polypeptide binding]; other site 767031002223 substrate binding site [chemical binding]; other site 767031002224 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767031002225 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767031002226 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 767031002227 active site 767031002228 Fic family protein [Function unknown]; Region: COG3177 767031002229 Fic/DOC family; Region: Fic; pfam02661 767031002230 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 767031002231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 767031002232 DNA binding residues [nucleotide binding] 767031002233 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 767031002234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031002235 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767031002236 active site 767031002237 DNA binding site [nucleotide binding] 767031002238 Int/Topo IB signature motif; other site 767031002239 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767031002240 30S subunit binding site; other site 767031002241 elongation factor Tu; Reviewed; Region: PRK12735 767031002242 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767031002243 G1 box; other site 767031002244 GEF interaction site [polypeptide binding]; other site 767031002245 GTP/Mg2+ binding site [chemical binding]; other site 767031002246 Switch I region; other site 767031002247 G2 box; other site 767031002248 G3 box; other site 767031002249 Switch II region; other site 767031002250 G4 box; other site 767031002251 G5 box; other site 767031002252 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767031002253 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767031002254 Antibiotic Binding Site [chemical binding]; other site 767031002255 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 767031002256 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767031002257 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767031002258 putative homodimer interface [polypeptide binding]; other site 767031002259 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767031002260 heterodimer interface [polypeptide binding]; other site 767031002261 homodimer interface [polypeptide binding]; other site 767031002262 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767031002263 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767031002264 23S rRNA interface [nucleotide binding]; other site 767031002265 L7/L12 interface [polypeptide binding]; other site 767031002266 putative thiostrepton binding site; other site 767031002267 L25 interface [polypeptide binding]; other site 767031002268 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767031002269 mRNA/rRNA interface [nucleotide binding]; other site 767031002270 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767031002271 23S rRNA interface [nucleotide binding]; other site 767031002272 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767031002273 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767031002274 core dimer interface [polypeptide binding]; other site 767031002275 peripheral dimer interface [polypeptide binding]; other site 767031002276 L10 interface [polypeptide binding]; other site 767031002277 L11 interface [polypeptide binding]; other site 767031002278 putative EF-Tu interaction site [polypeptide binding]; other site 767031002279 putative EF-G interaction site [polypeptide binding]; other site 767031002280 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 767031002281 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767031002282 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767031002283 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767031002284 RPB12 interaction site [polypeptide binding]; other site 767031002285 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767031002286 RPB11 interaction site [polypeptide binding]; other site 767031002287 RPB12 interaction site [polypeptide binding]; other site 767031002288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767031002289 RPB3 interaction site [polypeptide binding]; other site 767031002290 RPB1 interaction site [polypeptide binding]; other site 767031002291 RPB11 interaction site [polypeptide binding]; other site 767031002292 RPB10 interaction site [polypeptide binding]; other site 767031002293 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767031002294 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 767031002295 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767031002296 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767031002297 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767031002298 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 767031002299 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 767031002300 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767031002301 DNA binding site [nucleotide binding] 767031002302 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767031002303 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 767031002304 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 767031002305 DDE superfamily endonuclease; Region: DDE_5; cl17874 767031002306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 767031002307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767031002308 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 767031002309 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 767031002310 Sulfatase; Region: Sulfatase; pfam00884 767031002311 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767031002312 S17 interaction site [polypeptide binding]; other site 767031002313 S8 interaction site; other site 767031002314 16S rRNA interaction site [nucleotide binding]; other site 767031002315 streptomycin interaction site [chemical binding]; other site 767031002316 23S rRNA interaction site [nucleotide binding]; other site 767031002317 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767031002318 30S ribosomal protein S7; Validated; Region: PRK05302 767031002319 elongation factor G; Reviewed; Region: PRK12739 767031002320 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767031002321 G1 box; other site 767031002322 putative GEF interaction site [polypeptide binding]; other site 767031002323 GTP/Mg2+ binding site [chemical binding]; other site 767031002324 Switch I region; other site 767031002325 G2 box; other site 767031002326 G3 box; other site 767031002327 Switch II region; other site 767031002328 G4 box; other site 767031002329 G5 box; other site 767031002330 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767031002331 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767031002332 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767031002333 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767031002334 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767031002335 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767031002336 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767031002337 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767031002338 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767031002339 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767031002340 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767031002341 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767031002342 putative translocon binding site; other site 767031002343 protein-rRNA interface [nucleotide binding]; other site 767031002344 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767031002345 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767031002346 G-X-X-G motif; other site 767031002347 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767031002348 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767031002349 23S rRNA interface [nucleotide binding]; other site 767031002350 5S rRNA interface [nucleotide binding]; other site 767031002351 putative antibiotic binding site [chemical binding]; other site 767031002352 L25 interface [polypeptide binding]; other site 767031002353 L27 interface [polypeptide binding]; other site 767031002354 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767031002355 23S rRNA interface [nucleotide binding]; other site 767031002356 putative translocon interaction site; other site 767031002357 signal recognition particle (SRP54) interaction site; other site 767031002358 L23 interface [polypeptide binding]; other site 767031002359 trigger factor interaction site; other site 767031002360 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767031002361 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767031002362 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 767031002363 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767031002364 RNA binding site [nucleotide binding]; other site 767031002365 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767031002366 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767031002367 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767031002368 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 767031002369 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767031002370 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767031002371 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767031002372 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767031002373 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767031002374 5S rRNA interface [nucleotide binding]; other site 767031002375 23S rRNA interface [nucleotide binding]; other site 767031002376 L5 interface [polypeptide binding]; other site 767031002377 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 767031002378 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767031002379 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767031002380 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767031002381 23S rRNA binding site [nucleotide binding]; other site 767031002382 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767031002383 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767031002384 SecY translocase; Region: SecY; pfam00344 767031002385 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767031002386 active site 767031002387 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767031002388 rRNA binding site [nucleotide binding]; other site 767031002389 predicted 30S ribosome binding site; other site 767031002390 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 767031002391 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 767031002392 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767031002393 30S ribosomal protein S11; Validated; Region: PRK05309 767031002394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767031002395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767031002396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767031002397 RNA binding surface [nucleotide binding]; other site 767031002398 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767031002399 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767031002400 alphaNTD - beta interaction site [polypeptide binding]; other site 767031002401 alphaNTD homodimer interface [polypeptide binding]; other site 767031002402 alphaNTD - beta' interaction site [polypeptide binding]; other site 767031002403 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767031002404 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767031002405 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 767031002406 Protein of unknown function (DUF524); Region: DUF524; pfam04411 767031002407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767031002408 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 767031002409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767031002410 non-specific DNA binding site [nucleotide binding]; other site 767031002411 salt bridge; other site 767031002412 sequence-specific DNA binding site [nucleotide binding]; other site 767031002413 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767031002414 substrate binding site [chemical binding]; other site 767031002415 THF binding site; other site 767031002416 zinc-binding site [ion binding]; other site 767031002417 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767031002418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767031002419 putative DNA binding site [nucleotide binding]; other site 767031002420 putative Zn2+ binding site [ion binding]; other site 767031002421 AsnC family; Region: AsnC_trans_reg; pfam01037 767031002422 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 767031002423 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 767031002424 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 767031002425 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 767031002426 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 767031002427 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 767031002428 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 767031002429 putative DNA binding site [nucleotide binding]; other site 767031002430 putative Zn2+ binding site [ion binding]; other site 767031002431 AsnC family; Region: AsnC_trans_reg; pfam01037 767031002432 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 767031002433 recombination protein RecR; Reviewed; Region: recR; PRK00076 767031002434 RecR protein; Region: RecR; pfam02132 767031002435 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767031002436 putative active site [active] 767031002437 putative metal-binding site [ion binding]; other site 767031002438 tetramer interface [polypeptide binding]; other site 767031002439 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 767031002440 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 767031002441 Probable Catalytic site; other site 767031002442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031002443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 767031002444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767031002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767031002446 Coenzyme A binding pocket [chemical binding]; other site 767031002447 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031002448 active site 767031002449 catalytic residues [active] 767031002450 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031002451 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031002452 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031002453 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031002454 SusD family; Region: SusD; pfam07980 767031002455 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031002456 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031002457 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031002458 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031002459 putative transporter; Validated; Region: PRK03818 767031002460 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767031002461 TrkA-C domain; Region: TrkA_C; pfam02080 767031002462 TrkA-C domain; Region: TrkA_C; pfam02080 767031002463 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767031002464 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031002465 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767031002466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031002467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031002468 DNA binding residues [nucleotide binding] 767031002469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 767031002470 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 767031002471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767031002472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031002473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767031002474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031002475 active site 767031002476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031002477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031002478 active site 767031002479 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767031002480 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767031002481 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031002482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031002483 active site 767031002484 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 767031002485 Peptidase C10 family; Region: Peptidase_C10; pfam01640 767031002486 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767031002487 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767031002488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031002489 DNA binding residues [nucleotide binding] 767031002490 Trehalase; Region: Trehalase; cl17346 767031002491 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 767031002492 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 767031002493 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 767031002494 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 767031002495 active site 767031002496 catalytic triad [active] 767031002497 oxyanion hole [active] 767031002498 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 767031002499 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767031002500 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031002501 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031002502 SusD family; Region: SusD; pfam07980 767031002503 Secretin and TonB N terminus short domain; Region: STN; pfam07660 767031002504 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031002505 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031002506 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031002507 FecR protein; Region: FecR; pfam04773 767031002508 trehalose synthase; Region: treS_nterm; TIGR02456 767031002509 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 767031002510 active site 767031002511 catalytic site [active] 767031002512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767031002513 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767031002514 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767031002515 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767031002516 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767031002517 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767031002518 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 767031002519 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767031002520 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767031002521 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767031002522 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767031002523 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 767031002524 amino acid carrier protein; Region: agcS; TIGR00835 767031002525 Predicted membrane protein [Function unknown]; Region: COG2259 767031002526 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767031002527 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 767031002528 6-phosphofructokinase; Provisional; Region: PRK03202 767031002529 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767031002530 active site 767031002531 ADP/pyrophosphate binding site [chemical binding]; other site 767031002532 dimerization interface [polypeptide binding]; other site 767031002533 allosteric effector site; other site 767031002534 fructose-1,6-bisphosphate binding site; other site 767031002535 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767031002536 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767031002537 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767031002538 alpha subunit interaction interface [polypeptide binding]; other site 767031002539 Walker A motif; other site 767031002540 ATP binding site [chemical binding]; other site 767031002541 Walker B motif; other site 767031002542 inhibitor binding site; inhibition site 767031002543 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767031002544 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767031002545 gamma subunit interface [polypeptide binding]; other site 767031002546 LBP interface [polypeptide binding]; other site 767031002547 ATP synthase A chain; Region: ATP-synt_A; cl00413 767031002548 ATP synthase subunit C; Region: ATP-synt_C; cl00466 767031002549 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 767031002550 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 767031002551 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 767031002552 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 767031002553 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767031002554 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767031002555 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767031002556 beta subunit interaction interface [polypeptide binding]; other site 767031002557 Walker A motif; other site 767031002558 ATP binding site [chemical binding]; other site 767031002559 Walker B motif; other site 767031002560 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767031002561 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767031002562 core domain interface [polypeptide binding]; other site 767031002563 delta subunit interface [polypeptide binding]; other site 767031002564 epsilon subunit interface [polypeptide binding]; other site 767031002565 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031002566 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031002567 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031002568 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 767031002569 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 767031002570 active site triad [active] 767031002571 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767031002572 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 767031002573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031002574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767031002575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031002576 DNA binding residues [nucleotide binding] 767031002577 prolyl-tRNA synthetase; Provisional; Region: PRK08661 767031002578 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 767031002579 dimer interface [polypeptide binding]; other site 767031002580 motif 1; other site 767031002581 active site 767031002582 motif 2; other site 767031002583 motif 3; other site 767031002584 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 767031002585 anticodon binding site; other site 767031002586 zinc-binding site [ion binding]; other site 767031002587 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 767031002588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767031002589 ligand binding site [chemical binding]; other site 767031002590 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 767031002591 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767031002592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031002593 active site 767031002594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767031002595 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 767031002596 active site 767031002597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767031002598 substrate binding site [chemical binding]; other site 767031002599 catalytic residues [active] 767031002600 dimer interface [polypeptide binding]; other site 767031002601 aspartate kinase III; Validated; Region: PRK09084 767031002602 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 767031002603 putative catalytic residues [active] 767031002604 nucleotide binding site [chemical binding]; other site 767031002605 aspartate binding site [chemical binding]; other site 767031002606 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 767031002607 dimer interface [polypeptide binding]; other site 767031002608 allosteric regulatory binding pocket; other site 767031002609 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767031002610 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 767031002611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767031002612 Walker A/P-loop; other site 767031002613 ATP binding site [chemical binding]; other site 767031002614 Q-loop/lid; other site 767031002615 ABC transporter signature motif; other site 767031002616 Walker B; other site 767031002617 D-loop; other site 767031002618 H-loop/switch region; other site 767031002619 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767031002620 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 767031002621 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 767031002622 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 767031002623 active site 767031002624 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 767031002625 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031002626 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031002627 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031002628 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031002629 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 767031002630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 767031002631 N-terminal plug; other site 767031002632 ligand-binding site [chemical binding]; other site 767031002633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031002634 active site 767031002635 xanthine permease; Region: pbuX; TIGR03173 767031002636 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 767031002637 Gram-negative bacterial tonB protein; Region: TonB; cl10048 767031002638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 767031002639 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 767031002640 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767031002641 active site 767031002642 oxyanion hole [active] 767031002643 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 767031002644 active site 767031002645 putative catalytic site [active] 767031002646 DNA binding site [nucleotide binding] 767031002647 putative phosphate binding site [ion binding]; other site 767031002648 metal binding site A [ion binding]; metal-binding site 767031002649 AP binding site [nucleotide binding]; other site 767031002650 metal binding site B [ion binding]; metal-binding site 767031002651 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 767031002652 homodecamer interface [polypeptide binding]; other site 767031002653 GTP cyclohydrolase I; Provisional; Region: PLN03044 767031002654 active site 767031002655 putative catalytic site residues [active] 767031002656 zinc binding site [ion binding]; other site 767031002657 GTP-CH-I/GFRP interaction surface; other site 767031002658 Sporulation related domain; Region: SPOR; pfam05036 767031002659 triosephosphate isomerase; Provisional; Region: PRK14567 767031002660 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767031002661 substrate binding site [chemical binding]; other site 767031002662 dimer interface [polypeptide binding]; other site 767031002663 catalytic triad [active] 767031002664 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 767031002665 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 767031002666 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 767031002667 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767031002668 active site 767031002669 NTP binding site [chemical binding]; other site 767031002670 metal binding triad [ion binding]; metal-binding site 767031002671 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767031002672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031002673 Zn2+ binding site [ion binding]; other site 767031002674 Mg2+ binding site [ion binding]; other site 767031002675 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767031002676 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767031002677 HlyD family secretion protein; Region: HlyD_3; pfam13437 767031002678 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 767031002679 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 767031002680 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 767031002681 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767031002682 putative trimer interface [polypeptide binding]; other site 767031002683 putative CoA binding site [chemical binding]; other site 767031002684 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 767031002685 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 767031002686 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 767031002687 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 767031002688 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767031002689 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767031002690 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767031002691 DHH family; Region: DHH; pfam01368 767031002692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031002693 active site 767031002694 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 767031002695 IHF dimer interface [polypeptide binding]; other site 767031002696 IHF - DNA interface [nucleotide binding]; other site 767031002697 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 767031002698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031002699 putative substrate translocation pore; other site 767031002700 POT family; Region: PTR2; cl17359 767031002701 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031002702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767031002703 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 767031002704 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 767031002705 ligand binding site [chemical binding]; other site 767031002706 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 767031002707 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767031002708 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767031002709 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767031002710 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767031002711 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767031002712 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 767031002713 G1 box; other site 767031002714 putative GEF interaction site [polypeptide binding]; other site 767031002715 GTP/Mg2+ binding site [chemical binding]; other site 767031002716 Switch I region; other site 767031002717 G2 box; other site 767031002718 G3 box; other site 767031002719 Switch II region; other site 767031002720 G4 box; other site 767031002721 G5 box; other site 767031002722 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767031002723 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767031002724 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767031002725 16S/18S rRNA binding site [nucleotide binding]; other site 767031002726 S13e-L30e interaction site [polypeptide binding]; other site 767031002727 25S rRNA binding site [nucleotide binding]; other site 767031002728 Peptidase C10 family; Region: Peptidase_C10; pfam01640 767031002729 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 767031002730 catalytic center binding site [active] 767031002731 ATP binding site [chemical binding]; other site 767031002732 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 767031002733 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 767031002734 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767031002735 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 767031002736 RNA binding site [nucleotide binding]; other site 767031002737 active site 767031002738 Bacitracin resistance protein BacA; Region: BacA; pfam02673 767031002739 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 767031002740 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 767031002741 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 767031002742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031002743 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767031002744 FeS/SAM binding site; other site 767031002745 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 767031002746 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 767031002747 CoA binding domain; Region: CoA_binding; smart00881 767031002748 CoA-ligase; Region: Ligase_CoA; pfam00549 767031002749 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 767031002750 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 767031002751 CoA-ligase; Region: Ligase_CoA; pfam00549 767031002752 butyrate kinase; Provisional; Region: PRK03011 767031002753 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 767031002754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 767031002755 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 767031002756 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 767031002757 NAD(P) binding site [chemical binding]; other site 767031002758 homodimer interface [polypeptide binding]; other site 767031002759 substrate binding site [chemical binding]; other site 767031002760 active site 767031002761 Chain length determinant protein; Region: Wzz; pfam02706 767031002762 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 767031002763 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 767031002764 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 767031002765 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 767031002766 substrate binding site; other site 767031002767 tetramer interface; other site 767031002768 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 767031002769 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767031002770 Cell division protein ZapA; Region: ZapA; pfam05164 767031002771 phosphodiesterase; Provisional; Region: PRK12704 767031002772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031002773 Zn2+ binding site [ion binding]; other site 767031002774 Mg2+ binding site [ion binding]; other site 767031002775 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 767031002776 Catalytic site [active] 767031002777 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 767031002778 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 767031002779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031002780 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767031002781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031002782 DNA binding residues [nucleotide binding] 767031002783 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 767031002784 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767031002785 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767031002786 protein binding site [polypeptide binding]; other site 767031002787 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 767031002788 protein binding site [polypeptide binding]; other site 767031002789 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 767031002790 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 767031002791 active site 767031002792 nucleophile elbow; other site 767031002793 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 767031002794 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 767031002795 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 767031002796 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 767031002797 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 767031002798 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 767031002799 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 767031002800 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 767031002801 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767031002802 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 767031002803 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 767031002804 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 767031002805 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 767031002806 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 767031002807 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767031002808 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 767031002809 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767031002810 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 767031002811 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767031002812 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 767031002813 catalytic residues [active] 767031002814 dimer interface [polypeptide binding]; other site 767031002815 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767031002816 DNA binding site [nucleotide binding] 767031002817 active site 767031002818 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767031002819 Cation efflux family; Region: Cation_efflux; pfam01545 767031002820 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 767031002821 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 767031002822 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 767031002823 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 767031002824 Clp amino terminal domain; Region: Clp_N; pfam02861 767031002825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031002826 Walker A motif; other site 767031002827 ATP binding site [chemical binding]; other site 767031002828 Walker B motif; other site 767031002829 arginine finger; other site 767031002830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031002831 Walker A motif; other site 767031002832 ATP binding site [chemical binding]; other site 767031002833 Walker B motif; other site 767031002834 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767031002835 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 767031002836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031002837 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 767031002838 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767031002839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031002840 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767031002841 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767031002842 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 767031002843 putative active site [active] 767031002844 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 767031002845 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 767031002846 nucleotide binding pocket [chemical binding]; other site 767031002847 K-X-D-G motif; other site 767031002848 catalytic site [active] 767031002849 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767031002850 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767031002851 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767031002852 Dimer interface [polypeptide binding]; other site 767031002853 BRCT sequence motif; other site 767031002854 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767031002855 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 767031002856 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031002857 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031002858 active site 767031002859 GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103 767031002860 Stage II sporulation protein; Region: SpoIID; pfam08486 767031002861 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 767031002862 muropeptide transporter; Validated; Region: ampG; cl17669 767031002863 Peptidase family M48; Region: Peptidase_M48; pfam01435 767031002864 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 767031002865 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 767031002866 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 767031002867 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 767031002868 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 767031002869 active site 767031002870 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 767031002871 homodimer interface [polypeptide binding]; other site 767031002872 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767031002873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767031002874 Coenzyme A binding pocket [chemical binding]; other site 767031002875 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767031002876 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 767031002877 4Fe-4S binding domain; Region: Fer4; pfam00037 767031002878 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 767031002879 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 767031002880 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 767031002881 NodB motif; other site 767031002882 active site 767031002883 catalytic site [active] 767031002884 metal binding site [ion binding]; metal-binding site 767031002885 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 767031002886 DNA topoisomerase III; Provisional; Region: PRK07726 767031002887 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767031002888 active site 767031002889 putative interdomain interaction site [polypeptide binding]; other site 767031002890 putative metal-binding site [ion binding]; other site 767031002891 putative nucleotide binding site [chemical binding]; other site 767031002892 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767031002893 domain I; other site 767031002894 DNA binding groove [nucleotide binding] 767031002895 phosphate binding site [ion binding]; other site 767031002896 domain II; other site 767031002897 domain III; other site 767031002898 nucleotide binding site [chemical binding]; other site 767031002899 catalytic site [active] 767031002900 domain IV; other site 767031002901 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 767031002902 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767031002903 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 767031002904 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 767031002905 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 767031002906 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767031002907 HlyD family secretion protein; Region: HlyD_3; pfam13437 767031002908 Outer membrane efflux protein; Region: OEP; pfam02321 767031002909 Outer membrane efflux protein; Region: OEP; pfam02321 767031002910 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 767031002911 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 767031002912 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 767031002913 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 767031002914 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 767031002915 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767031002916 metal binding site 2 [ion binding]; metal-binding site 767031002917 putative DNA binding helix; other site 767031002918 metal binding site 1 [ion binding]; metal-binding site 767031002919 dimer interface [polypeptide binding]; other site 767031002920 structural Zn2+ binding site [ion binding]; other site 767031002921 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767031002922 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767031002923 GDP-binding site [chemical binding]; other site 767031002924 ACT binding site; other site 767031002925 IMP binding site; other site 767031002926 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767031002927 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767031002928 dimer interface [polypeptide binding]; other site 767031002929 motif 1; other site 767031002930 active site 767031002931 motif 2; other site 767031002932 motif 3; other site 767031002933 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767031002934 anticodon binding site; other site 767031002935 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767031002936 23S rRNA binding site [nucleotide binding]; other site 767031002937 L21 binding site [polypeptide binding]; other site 767031002938 L13 binding site [polypeptide binding]; other site 767031002939 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767031002940 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 767031002941 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767031002942 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767031002943 Heavy-metal-associated domain; Region: HMA; pfam00403 767031002944 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031002945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031002946 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767031002947 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767031002948 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767031002949 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767031002950 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767031002951 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 767031002952 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 767031002953 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 767031002954 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 767031002955 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 767031002956 putative active site [active] 767031002957 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 767031002958 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767031002959 PLD-like domain; Region: PLDc_2; pfam13091 767031002960 putative active site [active] 767031002961 catalytic site [active] 767031002962 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767031002963 PLD-like domain; Region: PLDc_2; pfam13091 767031002964 putative active site [active] 767031002965 catalytic site [active] 767031002966 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767031002967 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767031002968 substrate binding site [chemical binding]; other site 767031002969 hexamer interface [polypeptide binding]; other site 767031002970 metal binding site [ion binding]; metal-binding site 767031002971 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 767031002972 active site 767031002973 Glutamine amidotransferase class-I; Region: GATase; pfam00117 767031002974 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 767031002975 glutamine binding [chemical binding]; other site 767031002976 catalytic triad [active] 767031002977 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 767031002978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767031002979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767031002980 putative DNA binding site [nucleotide binding]; other site 767031002981 putative Zn2+ binding site [ion binding]; other site 767031002982 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767031002983 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031002984 catalytic residues [active] 767031002985 thiamine-monophosphate kinase; Region: thiL; TIGR01379 767031002986 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 767031002987 ATP binding site [chemical binding]; other site 767031002988 dimerization interface [polypeptide binding]; other site 767031002989 purine nucleoside phosphorylase; Provisional; Region: PRK08202 767031002990 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 767031002991 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 767031002992 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 767031002993 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 767031002994 tandem repeat interface [polypeptide binding]; other site 767031002995 oligomer interface [polypeptide binding]; other site 767031002996 active site residues [active] 767031002997 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 767031002998 tandem repeat interface [polypeptide binding]; other site 767031002999 oligomer interface [polypeptide binding]; other site 767031003000 active site residues [active] 767031003001 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 767031003002 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 767031003003 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767031003004 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767031003005 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 767031003006 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767031003007 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 767031003008 folate binding site [chemical binding]; other site 767031003009 NADP+ binding site [chemical binding]; other site 767031003010 thymidylate synthase; Reviewed; Region: thyA; PRK01827 767031003011 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767031003012 dimerization interface [polypeptide binding]; other site 767031003013 active site 767031003014 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 767031003015 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 767031003016 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 767031003017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031003018 binding surface 767031003019 TPR motif; other site 767031003020 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 767031003021 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 767031003022 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 767031003023 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767031003024 ligand binding site [chemical binding]; other site 767031003025 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767031003026 MutS domain III; Region: MutS_III; pfam05192 767031003027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031003028 Walker A/P-loop; other site 767031003029 ATP binding site [chemical binding]; other site 767031003030 Q-loop/lid; other site 767031003031 ABC transporter signature motif; other site 767031003032 Walker B; other site 767031003033 D-loop; other site 767031003034 H-loop/switch region; other site 767031003035 Smr domain; Region: Smr; pfam01713 767031003036 MG2 domain; Region: A2M_N; pfam01835 767031003037 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 767031003038 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031003039 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 767031003040 active site 767031003041 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 767031003042 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 767031003043 NodB motif; other site 767031003044 putative active site [active] 767031003045 putative catalytic site [active] 767031003046 putative Zn binding site [ion binding]; other site 767031003047 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 767031003048 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 767031003049 DXD motif; other site 767031003050 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 767031003051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031003052 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767031003053 active site 767031003054 motif I; other site 767031003055 motif II; other site 767031003056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031003057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031003058 S-adenosylmethionine binding site [chemical binding]; other site 767031003059 methionine sulfoxide reductase B; Provisional; Region: PRK00222 767031003060 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 767031003061 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 767031003062 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767031003063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767031003064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767031003065 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767031003066 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767031003067 Substrate-binding site [chemical binding]; other site 767031003068 Substrate specificity [chemical binding]; other site 767031003069 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767031003070 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767031003071 Substrate-binding site [chemical binding]; other site 767031003072 Substrate specificity [chemical binding]; other site 767031003073 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 767031003074 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 767031003075 PglZ domain; Region: PglZ; pfam08665 767031003076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767031003077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767031003078 DNA binding residues [nucleotide binding] 767031003079 dimerization interface [polypeptide binding]; other site 767031003080 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767031003081 EamA-like transporter family; Region: EamA; pfam00892 767031003082 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 767031003083 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 767031003084 active site 767031003085 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 767031003086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767031003087 active site 767031003088 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 767031003089 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 767031003090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031003091 motif II; other site 767031003092 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 767031003093 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 767031003094 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031003095 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 767031003096 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 767031003097 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767031003098 HSP70 interaction site [polypeptide binding]; other site 767031003099 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767031003100 dimer interface [polypeptide binding]; other site 767031003101 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 767031003102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 767031003103 active site 767031003104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767031003105 dimer interface [polypeptide binding]; other site 767031003106 catalytic residues [active] 767031003107 substrate binding site [chemical binding]; other site 767031003108 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767031003109 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767031003110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031003111 active site 767031003112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767031003113 serine O-acetyltransferase; Region: cysE; TIGR01172 767031003114 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 767031003115 trimer interface [polypeptide binding]; other site 767031003116 active site 767031003117 substrate binding site [chemical binding]; other site 767031003118 CoA binding site [chemical binding]; other site 767031003119 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767031003120 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767031003121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767031003122 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 767031003123 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 767031003124 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031003125 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767031003126 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767031003127 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767031003128 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767031003129 Predicted membrane protein [Function unknown]; Region: COG1238 767031003130 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031003131 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031003132 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031003133 Domain of unknown function (DUF386); Region: DUF386; cl01047 767031003134 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 767031003135 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 767031003136 active site 767031003137 Zn binding site [ion binding]; other site 767031003138 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767031003139 catalytic motif [active] 767031003140 Zn binding site [ion binding]; other site 767031003141 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767031003142 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 767031003143 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767031003144 protein binding site [polypeptide binding]; other site 767031003145 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767031003146 Catalytic dyad [active] 767031003147 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767031003148 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767031003149 NAD synthetase; Reviewed; Region: nadE; PRK02628 767031003150 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 767031003151 multimer interface [polypeptide binding]; other site 767031003152 active site 767031003153 catalytic triad [active] 767031003154 protein interface 1 [polypeptide binding]; other site 767031003155 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767031003156 homodimer interface [polypeptide binding]; other site 767031003157 NAD binding pocket [chemical binding]; other site 767031003158 ATP binding pocket [chemical binding]; other site 767031003159 Mg binding site [ion binding]; other site 767031003160 active-site loop [active] 767031003161 Domain of unknown function (DUF2027); Region: DUF2027; pfam09640 767031003162 Smr domain; Region: Smr; cl02619 767031003163 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 767031003164 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 767031003165 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 767031003166 active site 767031003167 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767031003168 Oxygen tolerance; Region: BatD; pfam13584 767031003169 TPR repeat; Region: TPR_11; pfam13414 767031003170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031003171 TPR motif; other site 767031003172 binding surface 767031003173 Bacterial SH3 domain homologues; Region: SH3b; smart00287 767031003174 TPR repeat; Region: TPR_11; pfam13414 767031003175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031003176 binding surface 767031003177 TPR motif; other site 767031003178 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031003179 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767031003180 metal ion-dependent adhesion site (MIDAS); other site 767031003181 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 767031003182 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 767031003183 metal ion-dependent adhesion site (MIDAS); other site 767031003184 Oxygen tolerance; Region: BatD; pfam13584 767031003185 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 767031003186 Protein of unknown function DUF58; Region: DUF58; pfam01882 767031003187 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767031003188 metal ion-dependent adhesion site (MIDAS); other site 767031003189 MoxR-like ATPases [General function prediction only]; Region: COG0714 767031003190 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 767031003191 ATP binding site [chemical binding]; other site 767031003192 Walker A motif; other site 767031003193 Walker B motif; other site 767031003194 arginine finger; other site 767031003195 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 767031003196 ResB-like family; Region: ResB; pfam05140 767031003197 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 767031003198 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 767031003199 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 767031003200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767031003201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767031003202 binding surface 767031003203 TPR motif; other site 767031003204 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767031003205 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767031003206 Walker A/P-loop; other site 767031003207 ATP binding site [chemical binding]; other site 767031003208 Q-loop/lid; other site 767031003209 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767031003210 ABC transporter signature motif; other site 767031003211 Walker B; other site 767031003212 D-loop; other site 767031003213 H-loop/switch region; other site 767031003214 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767031003215 Flavoprotein; Region: Flavoprotein; pfam02441 767031003216 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767031003217 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767031003218 active site 767031003219 catalytic site [active] 767031003220 substrate binding site [chemical binding]; other site 767031003221 DNA polymerase III subunit beta; Validated; Region: PRK05643 767031003222 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767031003223 putative DNA binding surface [nucleotide binding]; other site 767031003224 dimer interface [polypeptide binding]; other site 767031003225 beta-clamp/clamp loader binding surface; other site 767031003226 beta-clamp/translesion DNA polymerase binding surface; other site 767031003227 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 767031003228 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 767031003229 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 767031003230 putative NAD(P) binding site [chemical binding]; other site 767031003231 homodimer interface [polypeptide binding]; other site 767031003232 homotetramer interface [polypeptide binding]; other site 767031003233 active site 767031003234 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767031003235 Cysteine-rich domain; Region: CCG; pfam02754 767031003236 Cysteine-rich domain; Region: CCG; pfam02754 767031003237 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 767031003238 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 767031003239 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 767031003240 enolase; Provisional; Region: eno; PRK00077 767031003241 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767031003242 dimer interface [polypeptide binding]; other site 767031003243 metal binding site [ion binding]; metal-binding site 767031003244 substrate binding pocket [chemical binding]; other site 767031003245 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767031003246 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767031003247 Potassium binding sites [ion binding]; other site 767031003248 Cesium cation binding sites [ion binding]; other site 767031003249 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767031003250 active site 767031003251 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767031003252 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767031003253 active site 767031003254 catalytic triad [active] 767031003255 oxyanion hole [active] 767031003256 DNA repair protein RadA; Provisional; Region: PRK11823 767031003257 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767031003258 Walker A motif/ATP binding site; other site 767031003259 ATP binding site [chemical binding]; other site 767031003260 Walker B motif; other site 767031003261 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767031003262 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 767031003263 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767031003264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031003265 binding surface 767031003266 TPR motif; other site 767031003267 Protein of unknown function (DUF328); Region: DUF328; pfam03883 767031003268 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 767031003269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031003270 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 767031003271 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 767031003272 NADP binding site [chemical binding]; other site 767031003273 active site 767031003274 putative substrate binding site [chemical binding]; other site 767031003275 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 767031003276 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 767031003277 NADP-binding site; other site 767031003278 homotetramer interface [polypeptide binding]; other site 767031003279 substrate binding site [chemical binding]; other site 767031003280 homodimer interface [polypeptide binding]; other site 767031003281 active site 767031003282 hybrid cluster protein; Provisional; Region: PRK05290 767031003283 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767031003284 ACS interaction site; other site 767031003285 CODH interaction site; other site 767031003286 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 767031003287 hybrid metal cluster; other site 767031003288 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031003289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031003290 Peptidase family M49; Region: Peptidase_M49; pfam03571 767031003291 Uncharacterized conserved protein [Function unknown]; Region: COG3538 767031003292 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 767031003293 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 767031003294 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 767031003295 inhibitor-cofactor binding pocket; inhibition site 767031003296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031003297 catalytic residue [active] 767031003298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 767031003299 WxcM-like, C-terminal; Region: FdtA; pfam05523 767031003300 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 767031003301 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767031003302 ATP-grasp domain; Region: ATP-grasp; pfam02222 767031003303 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 767031003304 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 767031003305 NAD binding site [chemical binding]; other site 767031003306 substrate binding site [chemical binding]; other site 767031003307 homodimer interface [polypeptide binding]; other site 767031003308 active site 767031003309 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767031003310 active site 767031003311 metal binding site [ion binding]; metal-binding site 767031003312 homotetramer interface [polypeptide binding]; other site 767031003313 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 767031003314 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767031003315 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767031003316 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 767031003317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031003318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031003319 acyl-activating enzyme (AAE) consensus motif; other site 767031003320 acyl-activating enzyme (AAE) consensus motif; other site 767031003321 AMP binding site [chemical binding]; other site 767031003322 active site 767031003323 CoA binding site [chemical binding]; other site 767031003324 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 767031003325 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031003326 acyl-activating enzyme (AAE) consensus motif; other site 767031003327 AMP binding site [chemical binding]; other site 767031003328 active site 767031003329 CoA binding site [chemical binding]; other site 767031003330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767031003331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767031003332 ligand binding site [chemical binding]; other site 767031003333 flexible hinge region; other site 767031003334 GTP-binding protein LepA; Provisional; Region: PRK05433 767031003335 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767031003336 G1 box; other site 767031003337 putative GEF interaction site [polypeptide binding]; other site 767031003338 GTP/Mg2+ binding site [chemical binding]; other site 767031003339 Switch I region; other site 767031003340 G2 box; other site 767031003341 G3 box; other site 767031003342 Switch II region; other site 767031003343 G4 box; other site 767031003344 G5 box; other site 767031003345 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767031003346 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767031003347 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767031003348 DNA polymerase IV; Reviewed; Region: PRK03103 767031003349 Y-family of DNA polymerases; Region: PolY; cl12025 767031003350 active site 767031003351 DNA binding site [nucleotide binding] 767031003352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 767031003353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 767031003354 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 767031003355 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 767031003356 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 767031003357 active site 767031003358 catalytic site [active] 767031003359 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 767031003360 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 767031003361 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767031003362 imidazolonepropionase; Validated; Region: PRK09356 767031003363 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 767031003364 active site 767031003365 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 767031003366 active sites [active] 767031003367 tetramer interface [polypeptide binding]; other site 767031003368 urocanate hydratase; Provisional; Region: PRK05414 767031003369 glutamate formiminotransferase; Region: FtcD; TIGR02024 767031003370 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 767031003371 Formiminotransferase domain; Region: FTCD; pfam02971 767031003372 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 767031003373 DKNYY family; Region: DKNYY; pfam13644 767031003374 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 767031003375 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 767031003376 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767031003377 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767031003378 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767031003379 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767031003380 G1 box; other site 767031003381 GTP/Mg2+ binding site [chemical binding]; other site 767031003382 Switch I region; other site 767031003383 G2 box; other site 767031003384 Switch II region; other site 767031003385 G3 box; other site 767031003386 G4 box; other site 767031003387 G5 box; other site 767031003388 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767031003389 uracil transporter; Provisional; Region: PRK10720 767031003390 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 767031003391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767031003392 ABC-ATPase subunit interface; other site 767031003393 dimer interface [polypeptide binding]; other site 767031003394 putative PBP binding regions; other site 767031003395 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767031003396 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 767031003397 intersubunit interface [polypeptide binding]; other site 767031003398 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767031003399 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 767031003400 transmembrane helices; other site 767031003401 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031003402 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031003403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031003404 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767031003405 FeS/SAM binding site; other site 767031003406 MG2 domain; Region: A2M_N; pfam01835 767031003407 Alpha-2-macroglobulin family; Region: A2M; pfam00207 767031003408 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 767031003409 LytB protein; Region: LYTB; cl00507 767031003410 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 767031003411 heat shock protein 90; Provisional; Region: PRK05218 767031003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031003413 ATP binding site [chemical binding]; other site 767031003414 Mg2+ binding site [ion binding]; other site 767031003415 G-X-G motif; other site 767031003416 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 767031003417 A new structural DNA glycosylase; Region: AlkD_like; cd06561 767031003418 active site 767031003419 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767031003420 oligomerisation interface [polypeptide binding]; other site 767031003421 mobile loop; other site 767031003422 roof hairpin; other site 767031003423 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 767031003424 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767031003425 ring oligomerisation interface [polypeptide binding]; other site 767031003426 ATP/Mg binding site [chemical binding]; other site 767031003427 stacking interactions; other site 767031003428 hinge regions; other site 767031003429 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767031003430 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767031003431 G1 box; other site 767031003432 putative GEF interaction site [polypeptide binding]; other site 767031003433 GTP/Mg2+ binding site [chemical binding]; other site 767031003434 Switch I region; other site 767031003435 G2 box; other site 767031003436 G3 box; other site 767031003437 Switch II region; other site 767031003438 G4 box; other site 767031003439 G5 box; other site 767031003440 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 767031003441 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 767031003442 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 767031003443 NADP binding site [chemical binding]; other site 767031003444 active site 767031003445 putative substrate binding site [chemical binding]; other site 767031003446 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 767031003447 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767031003448 nucleotide binding site [chemical binding]; other site 767031003449 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767031003450 IHF dimer interface [polypeptide binding]; other site 767031003451 IHF - DNA interface [nucleotide binding]; other site 767031003452 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767031003453 IHF - DNA interface [nucleotide binding]; other site 767031003454 IHF dimer interface [polypeptide binding]; other site 767031003455 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 767031003456 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767031003457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031003458 FeS/SAM binding site; other site 767031003459 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 767031003460 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 767031003461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767031003462 OsmC-like protein; Region: OsmC; pfam02566 767031003463 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 767031003464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767031003465 motif II; other site 767031003466 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 767031003467 SLBB domain; Region: SLBB; pfam10531 767031003468 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767031003469 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767031003470 glutaminase active site [active] 767031003471 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767031003472 dimer interface [polypeptide binding]; other site 767031003473 active site 767031003474 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767031003475 dimer interface [polypeptide binding]; other site 767031003476 active site 767031003477 amidophosphoribosyltransferase; Provisional; Region: PRK06781 767031003478 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 767031003479 active site 767031003480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767031003481 active site 767031003482 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767031003483 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767031003484 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767031003485 catalytic site [active] 767031003486 subunit interface [polypeptide binding]; other site 767031003487 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 767031003488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767031003489 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767031003490 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767031003491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767031003492 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767031003493 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 767031003494 probable substrate binding site [chemical binding]; other site 767031003495 ATP cone domain; Region: ATP-cone; pfam03477 767031003496 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 767031003497 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767031003498 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 767031003499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031003500 motif II; other site 767031003501 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 767031003502 dimerization interface [polypeptide binding]; other site 767031003503 putative active cleft [active] 767031003504 RNA polymerase sigma factor; Provisional; Region: PRK12513 767031003505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031003506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031003507 DNA binding residues [nucleotide binding] 767031003508 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 767031003509 probable metal-binding protein; Region: matur_matur; TIGR03853 767031003510 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 767031003511 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031003512 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767031003513 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 767031003514 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767031003515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031003516 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767031003517 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 767031003518 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 767031003519 Probable Catalytic site; other site 767031003520 metal-binding site 767031003521 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 767031003522 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031003523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031003524 active site 767031003525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031003526 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767031003527 putative ADP-binding pocket [chemical binding]; other site 767031003528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031003529 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 767031003530 putative ADP-binding pocket [chemical binding]; other site 767031003531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767031003532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031003533 NAD(P) binding site [chemical binding]; other site 767031003534 active site 767031003535 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 767031003536 Mg++ binding site [ion binding]; other site 767031003537 putative catalytic motif [active] 767031003538 putative substrate binding site [chemical binding]; other site 767031003539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031003540 binding surface 767031003541 TPR motif; other site 767031003542 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 767031003543 catalytic center binding site [active] 767031003544 ATP binding site [chemical binding]; other site 767031003545 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 767031003546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 767031003547 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767031003548 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 767031003549 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 767031003550 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 767031003551 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767031003552 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 767031003553 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 767031003554 putative NADH binding site [chemical binding]; other site 767031003555 putative active site [active] 767031003556 nudix motif; other site 767031003557 putative metal binding site [ion binding]; other site 767031003558 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767031003559 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 767031003560 active site 767031003561 metal binding site [ion binding]; metal-binding site 767031003562 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767031003563 glutamate dehydrogenase; Provisional; Region: PRK14031 767031003564 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 767031003565 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 767031003566 NAD(P) binding site [chemical binding]; other site 767031003567 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767031003568 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 767031003569 ATP binding site [chemical binding]; other site 767031003570 Mg++ binding site [ion binding]; other site 767031003571 motif III; other site 767031003572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031003573 nucleotide binding region [chemical binding]; other site 767031003574 ATP-binding site [chemical binding]; other site 767031003575 Predicted permeases [General function prediction only]; Region: COG0795 767031003576 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 767031003577 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 767031003578 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 767031003579 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 767031003580 Found in ATP-dependent protease La (LON); Region: LON; smart00464 767031003581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031003582 Walker A motif; other site 767031003583 ATP binding site [chemical binding]; other site 767031003584 Walker B motif; other site 767031003585 arginine finger; other site 767031003586 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 767031003587 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 767031003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031003589 S-adenosylmethionine binding site [chemical binding]; other site 767031003590 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 767031003591 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767031003592 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 767031003593 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 767031003594 substrate-cofactor binding pocket; other site 767031003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031003596 catalytic residue [active] 767031003597 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767031003598 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767031003599 dimer interface [polypeptide binding]; other site 767031003600 ssDNA binding site [nucleotide binding]; other site 767031003601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767031003602 gliding motility-associated protein GldE; Region: GldE; TIGR03520 767031003603 Domain of unknown function DUF21; Region: DUF21; pfam01595 767031003604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767031003605 Transporter associated domain; Region: CorC_HlyC; smart01091 767031003606 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 767031003607 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 767031003608 Initiator Replication protein; Region: Rep_3; pfam01051 767031003609 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 767031003610 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 767031003611 Predicted membrane protein [Function unknown]; Region: COG2323 767031003612 signal recognition particle protein; Provisional; Region: PRK10867 767031003613 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767031003614 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767031003615 P loop; other site 767031003616 GTP binding site [chemical binding]; other site 767031003617 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767031003618 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 767031003619 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767031003620 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767031003621 homodimer interface [polypeptide binding]; other site 767031003622 NADP binding site [chemical binding]; other site 767031003623 substrate binding site [chemical binding]; other site 767031003624 TPR repeat; Region: TPR_11; pfam13414 767031003625 Tetratricopeptide repeat; Region: TPR_1; pfam00515 767031003626 Ferredoxin [Energy production and conversion]; Region: COG1146 767031003627 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767031003628 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 767031003629 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767031003630 dimer interface [polypeptide binding]; other site 767031003631 PYR/PP interface [polypeptide binding]; other site 767031003632 TPP binding site [chemical binding]; other site 767031003633 substrate binding site [chemical binding]; other site 767031003634 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 767031003635 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 767031003636 TPP-binding site [chemical binding]; other site 767031003637 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767031003638 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 767031003639 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767031003640 ligand binding site [chemical binding]; other site 767031003641 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767031003642 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 767031003643 active site 767031003644 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 767031003645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031003646 ATP binding site [chemical binding]; other site 767031003647 putative Mg++ binding site [ion binding]; other site 767031003648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031003649 nucleotide binding region [chemical binding]; other site 767031003650 ATP-binding site [chemical binding]; other site 767031003651 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767031003652 DHH family; Region: DHH; pfam01368 767031003653 DHHA1 domain; Region: DHHA1; pfam02272 767031003654 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 767031003655 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 767031003656 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767031003657 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 767031003658 active site 767031003659 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 767031003660 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 767031003661 active site 767031003662 nucleophile elbow; other site 767031003663 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 767031003664 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 767031003665 Imelysin; Region: Peptidase_M75; pfam09375 767031003666 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 767031003667 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767031003668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767031003669 DNA binding residues [nucleotide binding] 767031003670 dimerization interface [polypeptide binding]; other site 767031003671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767031003672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767031003673 DNA binding residues [nucleotide binding] 767031003674 dimerization interface [polypeptide binding]; other site 767031003675 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 767031003676 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 767031003677 Substrate binding site; other site 767031003678 metal-binding site 767031003679 GMP synthase; Reviewed; Region: guaA; PRK00074 767031003680 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767031003681 AMP/PPi binding site [chemical binding]; other site 767031003682 candidate oxyanion hole; other site 767031003683 catalytic triad [active] 767031003684 potential glutamine specificity residues [chemical binding]; other site 767031003685 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767031003686 ATP Binding subdomain [chemical binding]; other site 767031003687 Ligand Binding sites [chemical binding]; other site 767031003688 Dimerization subdomain; other site 767031003689 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767031003690 EamA-like transporter family; Region: EamA; pfam00892 767031003691 EamA-like transporter family; Region: EamA; pfam00892 767031003692 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767031003693 EamA-like transporter family; Region: EamA; cl17759 767031003694 EamA-like transporter family; Region: EamA; pfam00892 767031003695 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 767031003696 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 767031003697 FAD binding pocket [chemical binding]; other site 767031003698 FAD binding motif [chemical binding]; other site 767031003699 phosphate binding motif [ion binding]; other site 767031003700 beta-alpha-beta structure motif; other site 767031003701 NAD binding pocket [chemical binding]; other site 767031003702 Iron coordination center [ion binding]; other site 767031003703 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767031003704 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767031003705 heterodimer interface [polypeptide binding]; other site 767031003706 active site 767031003707 FMN binding site [chemical binding]; other site 767031003708 homodimer interface [polypeptide binding]; other site 767031003709 substrate binding site [chemical binding]; other site 767031003710 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 767031003711 catalytic triad [active] 767031003712 conserved cis-peptide bond; other site 767031003713 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 767031003714 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 767031003715 Tetramer interface [polypeptide binding]; other site 767031003716 active site 767031003717 FMN-binding site [chemical binding]; other site 767031003718 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 767031003719 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031003720 active site 767031003721 catalytic residues [active] 767031003722 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031003723 catalytic residues [active] 767031003724 flavodoxin FldA; Validated; Region: PRK09267 767031003725 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 767031003726 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 767031003727 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767031003728 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 767031003729 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 767031003730 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 767031003731 dimer interface [polypeptide binding]; other site 767031003732 FMN binding site [chemical binding]; other site 767031003733 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767031003734 dimer interface [polypeptide binding]; other site 767031003735 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767031003736 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767031003737 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767031003738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 767031003739 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767031003740 metal coordination site [ion binding]; other site 767031003741 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 767031003742 Prephenate dehydratase; Region: PDT; pfam00800 767031003743 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 767031003744 putative L-Phe binding site [chemical binding]; other site 767031003745 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 767031003746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767031003747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031003748 homodimer interface [polypeptide binding]; other site 767031003749 catalytic residue [active] 767031003750 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 767031003751 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 767031003752 Chorismate mutase type II; Region: CM_2; smart00830 767031003753 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 767031003754 prephenate dehydrogenase; Validated; Region: PRK08507 767031003755 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 767031003756 putative catalytic site [active] 767031003757 putative metal binding site [ion binding]; other site 767031003758 putative phosphate binding site [ion binding]; other site 767031003759 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 767031003760 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 767031003761 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767031003762 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 767031003763 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767031003764 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767031003765 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767031003766 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 767031003767 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767031003768 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 767031003769 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 767031003770 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 767031003771 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767031003772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031003773 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767031003774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767031003775 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767031003776 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 767031003777 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 767031003778 putative active site [active] 767031003779 catalytic site [active] 767031003780 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 767031003781 Phosphotransferase enzyme family; Region: APH; pfam01636 767031003782 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 767031003783 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 767031003784 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767031003785 putative active site [active] 767031003786 putative metal binding site [ion binding]; other site 767031003787 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 767031003788 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 767031003789 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 767031003790 MgtC family; Region: MgtC; pfam02308 767031003791 maltose O-acetyltransferase; Provisional; Region: PRK10092 767031003792 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767031003793 active site 767031003794 substrate binding site [chemical binding]; other site 767031003795 trimer interface [polypeptide binding]; other site 767031003796 CoA binding site [chemical binding]; other site 767031003797 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767031003798 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767031003799 putative active site [active] 767031003800 substrate binding site [chemical binding]; other site 767031003801 putative cosubstrate binding site; other site 767031003802 catalytic site [active] 767031003803 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767031003804 substrate binding site [chemical binding]; other site 767031003805 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 767031003806 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767031003807 Cl- selectivity filter; other site 767031003808 Cl- binding residues [ion binding]; other site 767031003809 pore gating glutamate residue; other site 767031003810 dimer interface [polypeptide binding]; other site 767031003811 FOG: CBS domain [General function prediction only]; Region: COG0517 767031003812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 767031003813 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 767031003814 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 767031003815 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 767031003816 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767031003817 dimer interface [polypeptide binding]; other site 767031003818 ADP-ribose binding site [chemical binding]; other site 767031003819 active site 767031003820 nudix motif; other site 767031003821 metal binding site [ion binding]; metal-binding site 767031003822 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767031003823 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767031003824 putative Zn-ribbon RNA-binding protein; Provisional; Region: PRK14890 767031003825 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 767031003826 Peptidase family U32; Region: Peptidase_U32; pfam01136 767031003827 Collagenase; Region: DUF3656; pfam12392 767031003828 Homoserine O-succinyltransferase; Region: HTS; pfam04204 767031003829 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 767031003830 proposed active site lysine [active] 767031003831 conserved cys residue [active] 767031003832 LysE type translocator; Region: LysE; cl00565 767031003833 Lipopolysaccharide-assembly; Region: LptE; pfam04390 767031003834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031003835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767031003836 Walker A motif; other site 767031003837 ATP binding site [chemical binding]; other site 767031003838 Walker B motif; other site 767031003839 arginine finger; other site 767031003840 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767031003841 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767031003842 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 767031003843 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 767031003844 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 767031003845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031003846 FeS/SAM binding site; other site 767031003847 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 767031003848 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 767031003849 active site 767031003850 substrate binding site [chemical binding]; other site 767031003851 metal binding site [ion binding]; metal-binding site 767031003852 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 767031003853 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 767031003854 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031003855 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031003856 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031003857 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031003858 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031003859 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 767031003860 AAA domain; Region: AAA_14; pfam13173 767031003861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 767031003862 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 767031003863 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767031003864 dimer interface [polypeptide binding]; other site 767031003865 PYR/PP interface [polypeptide binding]; other site 767031003866 TPP binding site [chemical binding]; other site 767031003867 substrate binding site [chemical binding]; other site 767031003868 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767031003869 Domain of unknown function; Region: EKR; pfam10371 767031003870 4Fe-4S binding domain; Region: Fer4_6; pfam12837 767031003871 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 767031003872 TPP-binding site [chemical binding]; other site 767031003873 dimer interface [polypeptide binding]; other site 767031003874 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031003875 Outer membrane efflux protein; Region: OEP; pfam02321 767031003876 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 767031003877 HlyD family secretion protein; Region: HlyD_3; pfam13437 767031003878 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 767031003879 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767031003880 Walker A/P-loop; other site 767031003881 ATP binding site [chemical binding]; other site 767031003882 Q-loop/lid; other site 767031003883 ABC transporter signature motif; other site 767031003884 Walker B; other site 767031003885 D-loop; other site 767031003886 H-loop/switch region; other site 767031003887 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 767031003888 Walker A/P-loop; other site 767031003889 ATP binding site [chemical binding]; other site 767031003890 Q-loop/lid; other site 767031003891 ABC transporter signature motif; other site 767031003892 Walker B; other site 767031003893 D-loop; other site 767031003894 H-loop/switch region; other site 767031003895 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767031003896 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767031003897 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767031003898 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767031003899 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 767031003900 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 767031003901 dimer interface [polypeptide binding]; other site 767031003902 active site 767031003903 glycine-pyridoxal phosphate binding site [chemical binding]; other site 767031003904 folate binding site [chemical binding]; other site 767031003905 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 767031003906 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031003907 Uncharacterized conserved protein [Function unknown]; Region: COG3391 767031003908 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 767031003909 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 767031003910 active site 767031003911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767031003912 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 767031003913 cation binding site [ion binding]; other site 767031003914 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031003915 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767031003916 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 767031003917 putative ligand binding site [chemical binding]; other site 767031003918 putative NAD binding site [chemical binding]; other site 767031003919 catalytic site [active] 767031003920 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767031003921 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 767031003922 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 767031003923 putative metal binding site [ion binding]; other site 767031003924 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767031003925 HSP70 interaction site [polypeptide binding]; other site 767031003926 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 767031003927 active site 767031003928 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 767031003929 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 767031003930 Putative zinc ribbon domain; Region: DUF164; pfam02591 767031003931 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767031003932 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767031003933 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 767031003934 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 767031003935 Ligand binding site; other site 767031003936 Putative Catalytic site; other site 767031003937 DXD motif; other site 767031003938 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767031003939 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767031003940 putative acyl-acceptor binding pocket; other site 767031003941 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 767031003942 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 767031003943 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767031003944 putative active site [active] 767031003945 putative metal binding site [ion binding]; other site 767031003946 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 767031003947 dihydroorotase; Reviewed; Region: PRK09236 767031003948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767031003949 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 767031003950 active site 767031003951 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 767031003952 Septum formation initiator; Region: DivIC; cl17659 767031003953 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 767031003954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031003955 Walker A motif; other site 767031003956 ATP binding site [chemical binding]; other site 767031003957 Walker B motif; other site 767031003958 arginine finger; other site 767031003959 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 767031003960 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767031003961 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767031003962 TrkA-C domain; Region: TrkA_C; pfam02080 767031003963 TrkA-C domain; Region: TrkA_C; pfam02080 767031003964 peptidase T; Region: peptidase-T; TIGR01882 767031003965 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767031003966 metal binding site [ion binding]; metal-binding site 767031003967 dimer interface [polypeptide binding]; other site 767031003968 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 767031003969 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 767031003970 asparagine synthetase AsnA; Provisional; Region: PRK05425 767031003971 motif 1; other site 767031003972 dimer interface [polypeptide binding]; other site 767031003973 active site 767031003974 motif 2; other site 767031003975 motif 3; other site 767031003976 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 767031003977 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 767031003978 putative active site; other site 767031003979 catalytic triad [active] 767031003980 putative dimer interface [polypeptide binding]; other site 767031003981 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 767031003982 FMN binding site [chemical binding]; other site 767031003983 dimer interface [polypeptide binding]; other site 767031003984 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 767031003985 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 767031003986 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 767031003987 hypothetical protein; Provisional; Region: PRK08201 767031003988 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 767031003989 metal binding site [ion binding]; metal-binding site 767031003990 putative dimer interface [polypeptide binding]; other site 767031003991 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 767031003992 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767031003993 Int/Topo IB signature motif; other site 767031003994 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 767031003995 PcfK-like protein; Region: PcfK; pfam14058 767031003996 Antirestriction protein (ArdA); Region: ArdA; cl01953 767031003997 PcfJ-like protein; Region: PcfJ; pfam14284 767031003998 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 767031003999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031004000 S-adenosylmethionine binding site [chemical binding]; other site 767031004001 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 767031004002 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 767031004003 Conjugative transposon protein TraO; Region: TraO; pfam10626 767031004004 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 767031004005 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 767031004006 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 767031004007 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 767031004008 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 767031004009 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 767031004010 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 767031004011 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 767031004012 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 767031004013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004014 Walker A/P-loop; other site 767031004015 ATP binding site [chemical binding]; other site 767031004016 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 767031004017 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031004018 AAA domain; Region: AAA_31; pfam13614 767031004019 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767031004020 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767031004021 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 767031004022 YWFCY protein; Region: YWFCY; pfam14293 767031004023 AAA-like domain; Region: AAA_10; pfam12846 767031004024 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 767031004025 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767031004026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767031004027 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767031004028 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 767031004029 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 767031004030 Protein export membrane protein; Region: SecD_SecF; cl14618 767031004031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767031004032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031004033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004034 Walker A/P-loop; other site 767031004035 ATP binding site [chemical binding]; other site 767031004036 Q-loop/lid; other site 767031004037 ABC transporter signature motif; other site 767031004038 Walker B; other site 767031004039 D-loop; other site 767031004040 H-loop/switch region; other site 767031004041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767031004042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031004043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004044 Walker A/P-loop; other site 767031004045 ATP binding site [chemical binding]; other site 767031004046 Q-loop/lid; other site 767031004047 ABC transporter signature motif; other site 767031004048 Walker B; other site 767031004049 D-loop; other site 767031004050 H-loop/switch region; other site 767031004051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767031004052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767031004053 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004054 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031004055 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767031004057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767031004058 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 767031004059 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 767031004060 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767031004061 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767031004062 DNA topoisomerase III; Provisional; Region: PRK07726 767031004063 active site 767031004064 putative interdomain interaction site [polypeptide binding]; other site 767031004065 putative metal-binding site [ion binding]; other site 767031004066 putative nucleotide binding site [chemical binding]; other site 767031004067 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767031004068 domain I; other site 767031004069 DNA binding groove [nucleotide binding] 767031004070 phosphate binding site [ion binding]; other site 767031004071 domain II; other site 767031004072 domain III; other site 767031004073 nucleotide binding site [chemical binding]; other site 767031004074 catalytic site [active] 767031004075 domain IV; other site 767031004076 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767031004077 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767031004078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031004079 S-adenosylmethionine binding site [chemical binding]; other site 767031004080 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 767031004081 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 767031004082 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767031004083 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 767031004084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767031004085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767031004086 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767031004087 dimer interface [polypeptide binding]; other site 767031004088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767031004089 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767031004090 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 767031004091 active site 767031004092 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 767031004093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031004094 FeS/SAM binding site; other site 767031004095 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767031004096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004097 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 767031004098 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 767031004099 putative active site [active] 767031004100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031004101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004102 Walker A/P-loop; other site 767031004103 ATP binding site [chemical binding]; other site 767031004104 Q-loop/lid; other site 767031004105 ABC transporter signature motif; other site 767031004106 Walker B; other site 767031004107 D-loop; other site 767031004108 H-loop/switch region; other site 767031004109 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031004110 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031004111 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031004112 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 767031004113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031004114 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767031004115 active site 767031004116 DNA binding site [nucleotide binding] 767031004117 Int/Topo IB signature motif; other site 767031004118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031004119 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767031004120 active site 767031004121 DNA binding site [nucleotide binding] 767031004122 Int/Topo IB signature motif; other site 767031004123 helicase superfamily c-terminal domain; Region: HELICc; smart00490 767031004124 ATP-binding site [chemical binding]; other site 767031004125 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767031004126 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767031004127 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 767031004128 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031004129 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 767031004130 active site 767031004131 metal binding site [ion binding]; metal-binding site 767031004132 interdomain interaction site; other site 767031004133 AAA domain; Region: AAA_25; pfam13481 767031004134 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767031004135 Walker A motif; other site 767031004136 ATP binding site [chemical binding]; other site 767031004137 Walker B motif; other site 767031004138 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 767031004139 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031004140 catalytic residues [active] 767031004141 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 767031004142 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 767031004143 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 767031004144 active site 767031004145 catalytic residues [active] 767031004146 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767031004147 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767031004148 metal-binding site [ion binding] 767031004149 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767031004150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031004151 active site 767031004152 motif I; other site 767031004153 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767031004154 motif II; other site 767031004155 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767031004156 metal-binding site [ion binding] 767031004157 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 767031004158 Divergent AAA domain; Region: AAA_4; pfam04326 767031004159 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 767031004160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031004161 Zn2+ binding site [ion binding]; other site 767031004162 Mg2+ binding site [ion binding]; other site 767031004163 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767031004164 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767031004165 active site 767031004166 Zn binding site [ion binding]; other site 767031004167 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767031004168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031004169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031004170 ABC transporter; Region: ABC_tran_2; pfam12848 767031004171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031004172 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 767031004173 Ferritin-like domain; Region: Ferritin; pfam00210 767031004174 ferroxidase diiron center [ion binding]; other site 767031004175 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767031004176 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767031004177 homodimer interface [polypeptide binding]; other site 767031004178 substrate-cofactor binding pocket; other site 767031004179 catalytic residue [active] 767031004180 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767031004181 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767031004182 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767031004183 generic binding surface II; other site 767031004184 generic binding surface I; other site 767031004185 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 767031004186 active site 767031004187 catalytic triad [active] 767031004188 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767031004189 active site 767031004190 catalytic site [active] 767031004191 substrate binding site [chemical binding]; other site 767031004192 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 767031004193 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 767031004194 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 767031004195 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767031004196 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 767031004197 ligand binding site [chemical binding]; other site 767031004198 flexible hinge region; other site 767031004199 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 767031004200 putative switch regulator; other site 767031004201 non-specific DNA interactions [nucleotide binding]; other site 767031004202 DNA binding site [nucleotide binding] 767031004203 sequence specific DNA binding site [nucleotide binding]; other site 767031004204 putative cAMP binding site [chemical binding]; other site 767031004205 Hemerythrin-like domain; Region: Hr-like; cd12108 767031004206 Fe binding site [ion binding]; other site 767031004207 Uncharacterized conserved protein [Function unknown]; Region: COG3189 767031004208 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767031004209 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 767031004210 putative dimer interface [polypeptide binding]; other site 767031004211 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767031004212 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767031004213 CoA-binding site [chemical binding]; other site 767031004214 ATP-binding [chemical binding]; other site 767031004215 YbbR-like protein; Region: YbbR; pfam07949 767031004216 Preprotein translocase subunit; Region: YajC; pfam02699 767031004217 transcription antitermination factor NusB; Region: nusB; TIGR01951 767031004218 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 767031004219 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 767031004220 5S rRNA interface [nucleotide binding]; other site 767031004221 CTC domain interface [polypeptide binding]; other site 767031004222 L16 interface [polypeptide binding]; other site 767031004223 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767031004224 putative active site [active] 767031004225 catalytic residue [active] 767031004226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767031004227 RNA binding surface [nucleotide binding]; other site 767031004228 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 767031004229 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 767031004230 metal binding site [ion binding]; metal-binding site 767031004231 dimer interface [polypeptide binding]; other site 767031004232 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767031004233 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767031004234 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 767031004235 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 767031004236 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767031004237 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767031004238 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767031004239 hinge region; other site 767031004240 GTPase RsgA; Reviewed; Region: PRK00098 767031004241 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767031004242 RNA binding site [nucleotide binding]; other site 767031004243 homodimer interface [polypeptide binding]; other site 767031004244 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767031004245 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767031004246 GTP/Mg2+ binding site [chemical binding]; other site 767031004247 G4 box; other site 767031004248 G5 box; other site 767031004249 G1 box; other site 767031004250 Switch I region; other site 767031004251 G2 box; other site 767031004252 G3 box; other site 767031004253 Switch II region; other site 767031004254 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767031004255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031004256 motif II; other site 767031004257 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 767031004258 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767031004259 active site 767031004260 dimer interface [polypeptide binding]; other site 767031004261 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767031004262 dimer interface [polypeptide binding]; other site 767031004263 active site 767031004264 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 767031004265 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767031004266 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767031004267 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767031004268 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767031004269 dimer interface [polypeptide binding]; other site 767031004270 putative anticodon binding site; other site 767031004271 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767031004272 motif 1; other site 767031004273 active site 767031004274 motif 2; other site 767031004275 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 767031004276 motif 3; other site 767031004277 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767031004278 CoenzymeA binding site [chemical binding]; other site 767031004279 subunit interaction site [polypeptide binding]; other site 767031004280 PHB binding site; other site 767031004281 chorismate binding enzyme; Region: Chorismate_bind; cl10555 767031004282 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 767031004283 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 767031004284 dimer interface [polypeptide binding]; other site 767031004285 tetramer interface [polypeptide binding]; other site 767031004286 PYR/PP interface [polypeptide binding]; other site 767031004287 TPP binding site [chemical binding]; other site 767031004288 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767031004289 TPP-binding site [chemical binding]; other site 767031004290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767031004291 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 767031004292 substrate binding site [chemical binding]; other site 767031004293 oxyanion hole (OAH) forming residues; other site 767031004294 trimer interface [polypeptide binding]; other site 767031004295 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767031004296 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 767031004297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031004298 ATP binding site [chemical binding]; other site 767031004299 putative Mg++ binding site [ion binding]; other site 767031004300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031004301 nucleotide binding region [chemical binding]; other site 767031004302 ATP-binding site [chemical binding]; other site 767031004303 TRCF domain; Region: TRCF; pfam03461 767031004304 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 767031004305 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 767031004306 active site 767031004307 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 767031004308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031004309 acyl-activating enzyme (AAE) consensus motif; other site 767031004310 AMP binding site [chemical binding]; other site 767031004311 active site 767031004312 CoA binding site [chemical binding]; other site 767031004313 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767031004314 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767031004315 Cl binding site [ion binding]; other site 767031004316 oligomer interface [polypeptide binding]; other site 767031004317 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 767031004318 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 767031004319 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 767031004320 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 767031004321 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 767031004322 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767031004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031004324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767031004325 active site residue [active] 767031004326 Oligomerisation domain; Region: Oligomerisation; pfam02410 767031004327 FtsH Extracellular; Region: FtsH_ext; pfam06480 767031004328 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767031004329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031004330 Walker A motif; other site 767031004331 ATP binding site [chemical binding]; other site 767031004332 Walker B motif; other site 767031004333 arginine finger; other site 767031004334 Peptidase family M41; Region: Peptidase_M41; pfam01434 767031004335 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767031004336 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767031004337 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031004338 SprT homologues; Region: SprT; cl01182 767031004339 SprT-like family; Region: SprT-like; pfam10263 767031004340 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 767031004341 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 767031004342 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 767031004343 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004344 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 767031004345 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004346 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031004347 active site 767031004348 DNA binding site [nucleotide binding] 767031004349 Int/Topo IB signature motif; other site 767031004350 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767031004351 trimer interface [polypeptide binding]; other site 767031004352 active site 767031004353 G bulge; other site 767031004354 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 767031004355 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 767031004356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767031004357 putative active site [active] 767031004358 putative metal binding site [ion binding]; other site 767031004359 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031004360 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031004361 SusD family; Region: SusD; pfam07980 767031004362 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031004363 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031004364 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 767031004365 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767031004366 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767031004367 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767031004368 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 767031004369 AAA domain; Region: AAA_30; pfam13604 767031004370 Family description; Region: UvrD_C_2; pfam13538 767031004371 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 767031004372 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767031004373 TPP-binding site; other site 767031004374 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767031004375 PYR/PP interface [polypeptide binding]; other site 767031004376 dimer interface [polypeptide binding]; other site 767031004377 TPP binding site [chemical binding]; other site 767031004378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767031004379 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767031004380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004381 Walker A/P-loop; other site 767031004382 ATP binding site [chemical binding]; other site 767031004383 Q-loop/lid; other site 767031004384 ABC transporter signature motif; other site 767031004385 Walker B; other site 767031004386 D-loop; other site 767031004387 H-loop/switch region; other site 767031004388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767031004389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767031004390 Walker A/P-loop; other site 767031004391 ATP binding site [chemical binding]; other site 767031004392 Q-loop/lid; other site 767031004393 ABC transporter signature motif; other site 767031004394 Walker B; other site 767031004395 D-loop; other site 767031004396 H-loop/switch region; other site 767031004397 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767031004398 HD domain; Region: HD_4; pfam13328 767031004399 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767031004400 synthetase active site [active] 767031004401 NTP binding site [chemical binding]; other site 767031004402 metal binding site [ion binding]; metal-binding site 767031004403 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767031004404 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767031004405 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 767031004406 ParB-like nuclease domain; Region: ParBc; pfam02195 767031004407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767031004408 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767031004409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767031004410 P-loop; other site 767031004411 Magnesium ion binding site [ion binding]; other site 767031004412 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767031004413 Magnesium ion binding site [ion binding]; other site 767031004414 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 767031004415 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 767031004416 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 767031004417 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767031004418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767031004419 Walker A/P-loop; other site 767031004420 ATP binding site [chemical binding]; other site 767031004421 Q-loop/lid; other site 767031004422 ABC transporter signature motif; other site 767031004423 Walker B; other site 767031004424 D-loop; other site 767031004425 H-loop/switch region; other site 767031004426 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 767031004427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767031004428 DNA-binding site [nucleotide binding]; DNA binding site 767031004429 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767031004430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031004431 ATP binding site [chemical binding]; other site 767031004432 putative Mg++ binding site [ion binding]; other site 767031004433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031004434 nucleotide binding region [chemical binding]; other site 767031004435 ATP-binding site [chemical binding]; other site 767031004436 recombinase A; Provisional; Region: recA; PRK09354 767031004437 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767031004438 hexamer interface [polypeptide binding]; other site 767031004439 Walker A motif; other site 767031004440 ATP binding site [chemical binding]; other site 767031004441 Walker B motif; other site 767031004442 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 767031004443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031004444 TPR motif; other site 767031004445 binding surface 767031004446 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031004447 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 767031004448 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 767031004449 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 767031004450 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767031004451 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767031004452 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767031004453 motif 1; other site 767031004454 active site 767031004455 motif 2; other site 767031004456 motif 3; other site 767031004457 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767031004458 DHHA1 domain; Region: DHHA1; pfam02272 767031004459 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767031004460 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767031004461 DNA binding residues [nucleotide binding] 767031004462 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 767031004463 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 767031004464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031004465 S-adenosylmethionine binding site [chemical binding]; other site 767031004466 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767031004467 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 767031004468 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767031004469 putative active site [active] 767031004470 catalytic site [active] 767031004471 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767031004472 putative active site [active] 767031004473 catalytic site [active] 767031004474 DNA primase, catalytic core; Region: dnaG; TIGR01391 767031004475 CHC2 zinc finger; Region: zf-CHC2; pfam01807 767031004476 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767031004477 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767031004478 active site 767031004479 metal binding site [ion binding]; metal-binding site 767031004480 interdomain interaction site; other site 767031004481 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 767031004482 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 767031004483 Ligand binding site [chemical binding]; other site 767031004484 Electron transfer flavoprotein domain; Region: ETF; pfam01012 767031004485 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 767031004486 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 767031004487 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 767031004488 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 767031004489 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767031004490 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767031004491 active site 767031004492 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 767031004493 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 767031004494 Predicted ATPase [General function prediction only]; Region: COG4637 767031004495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 767031004496 ABC transporter signature motif; other site 767031004497 Walker B; other site 767031004498 D-loop; other site 767031004499 H-loop/switch region; other site 767031004500 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 767031004501 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767031004502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767031004503 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 767031004504 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 767031004505 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 767031004506 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 767031004507 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 767031004508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031004509 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767031004510 RuvA N terminal domain; Region: RuvA_N; pfam01330 767031004511 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 767031004512 cell surface protein SprA; Region: surface_SprA; TIGR04189 767031004513 Motility related/secretion protein; Region: SprA_N; pfam14349 767031004514 Motility related/secretion protein; Region: SprA_N; pfam14349 767031004515 Motility related/secretion protein; Region: SprA_N; pfam14349 767031004516 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 767031004517 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 767031004518 active site triad [active] 767031004519 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 767031004520 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 767031004521 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 767031004522 SIR2-like domain; Region: SIR2_2; pfam13289 767031004523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767031004524 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767031004525 BRO family, N-terminal domain; Region: Bro-N; cl10591 767031004526 Virulence-associated protein E; Region: VirE; pfam05272 767031004527 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 767031004528 multiple promoter invertase; Provisional; Region: mpi; PRK13413 767031004529 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767031004530 catalytic residues [active] 767031004531 catalytic nucleophile [active] 767031004532 Presynaptic Site I dimer interface [polypeptide binding]; other site 767031004533 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767031004534 Synaptic Flat tetramer interface [polypeptide binding]; other site 767031004535 Synaptic Site I dimer interface [polypeptide binding]; other site 767031004536 DNA binding site [nucleotide binding] 767031004537 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 767031004538 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 767031004539 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767031004540 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 767031004541 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 767031004542 putative homodimer interface [polypeptide binding]; other site 767031004543 putative active site [active] 767031004544 catalytic site [active] 767031004545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031004546 ATP binding site [chemical binding]; other site 767031004547 putative Mg++ binding site [ion binding]; other site 767031004548 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 767031004549 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031004550 nucleotide binding region [chemical binding]; other site 767031004551 ATP-binding site [chemical binding]; other site 767031004552 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 767031004553 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767031004554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767031004555 ATP binding site [chemical binding]; other site 767031004556 putative Mg++ binding site [ion binding]; other site 767031004557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 767031004558 nucleotide binding region [chemical binding]; other site 767031004559 ATP-binding site [chemical binding]; other site 767031004560 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 767031004561 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 767031004562 Fic/DOC family; Region: Fic; pfam02661 767031004563 BRO family, N-terminal domain; Region: Bro-N; cl10591 767031004564 CAAX protease self-immunity; Region: Abi; pfam02517 767031004565 BRO family, N-terminal domain; Region: Bro-N; cl10591 767031004566 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 767031004567 Fic/DOC family; Region: Fic; pfam02661 767031004568 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 767031004569 FIC domain binding interface [polypeptide binding]; other site 767031004570 Fic/DOC family; Region: Fic; pfam02661 767031004571 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 767031004572 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 767031004573 Virulence-associated protein E; Region: VirE; pfam05272 767031004574 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 767031004575 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767031004576 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767031004577 nucleotide binding site [chemical binding]; other site 767031004578 NEF interaction site [polypeptide binding]; other site 767031004579 SBD interface [polypeptide binding]; other site 767031004580 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 767031004581 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 767031004582 CAP-like domain; other site 767031004583 active site 767031004584 primary dimer interface [polypeptide binding]; other site 767031004585 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 767031004586 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 767031004587 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 767031004588 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 767031004589 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 767031004590 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767031004591 Sugar specificity; other site 767031004592 Pyrimidine base specificity; other site 767031004593 ATP-binding site [chemical binding]; other site 767031004594 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 767031004595 putative active site [active] 767031004596 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 767031004597 putative catalytic site [active] 767031004598 putative metal binding site [ion binding]; other site 767031004599 putative phosphate binding site [ion binding]; other site 767031004600 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004601 RPA2_OBF_family: A family of oligonucleotide binding (OB) folds with similarity to the OB fold of the single strand (ss) DNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear...; Region: RPA2_OBF_family; cd03524 767031004602 generic binding surface I; other site 767031004603 generic binding surface II; other site 767031004604 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 767031004605 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 767031004606 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767031004607 active site 767031004608 substrate binding site [chemical binding]; other site 767031004609 Mg2+ binding site [ion binding]; other site 767031004610 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 767031004611 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767031004612 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 767031004613 Probable Catalytic site; other site 767031004614 metal-binding site 767031004615 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 767031004616 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767031004617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031004618 FeS/SAM binding site; other site 767031004619 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 767031004620 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 767031004621 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 767031004622 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 767031004623 N-terminal plug; other site 767031004624 ligand-binding site [chemical binding]; other site 767031004625 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 767031004626 SecA binding site; other site 767031004627 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 767031004628 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767031004629 catalytic residues [active] 767031004630 Outer membrane protein Omp28; Region: Omp28; pfam11551 767031004631 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031004632 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 767031004633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004634 Walker A/P-loop; other site 767031004635 ATP binding site [chemical binding]; other site 767031004636 Q-loop/lid; other site 767031004637 ABC transporter signature motif; other site 767031004638 Walker B; other site 767031004639 D-loop; other site 767031004640 H-loop/switch region; other site 767031004641 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 767031004642 Protein of unknown function DUF58; Region: DUF58; pfam01882 767031004643 MoxR-like ATPases [General function prediction only]; Region: COG0714 767031004644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767031004645 Walker B motif; other site 767031004646 arginine finger; other site 767031004647 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 767031004648 Integral membrane protein DUF95; Region: DUF95; pfam01944 767031004649 RDD family; Region: RDD; pfam06271 767031004650 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 767031004651 Pyruvate formate lyase 1; Region: PFL1; cd01678 767031004652 coenzyme A binding site [chemical binding]; other site 767031004653 active site 767031004654 catalytic residues [active] 767031004655 glycine loop; other site 767031004656 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 767031004657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031004658 FeS/SAM binding site; other site 767031004659 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 767031004660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004661 Walker A/P-loop; other site 767031004662 ATP binding site [chemical binding]; other site 767031004663 Q-loop/lid; other site 767031004664 ABC transporter signature motif; other site 767031004665 Walker B; other site 767031004666 D-loop; other site 767031004667 H-loop/switch region; other site 767031004668 ABC transporter; Region: ABC_tran_2; pfam12848 767031004669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031004670 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 767031004671 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767031004672 dimer interface [polypeptide binding]; other site 767031004673 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767031004674 chaperone protein DnaJ; Provisional; Region: PRK14289 767031004675 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767031004676 HSP70 interaction site [polypeptide binding]; other site 767031004677 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 767031004678 substrate binding site [polypeptide binding]; other site 767031004679 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767031004680 Zn binding sites [ion binding]; other site 767031004681 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767031004682 dimer interface [polypeptide binding]; other site 767031004683 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 767031004684 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031004685 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 767031004686 Two component regulator propeller; Region: Reg_prop; pfam07494 767031004687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031004688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031004689 dimer interface [polypeptide binding]; other site 767031004690 phosphorylation site [posttranslational modification] 767031004691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031004692 ATP binding site [chemical binding]; other site 767031004693 Mg2+ binding site [ion binding]; other site 767031004694 G-X-G motif; other site 767031004695 Response regulator receiver domain; Region: Response_reg; pfam00072 767031004696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031004697 active site 767031004698 phosphorylation site [posttranslational modification] 767031004699 intermolecular recognition site; other site 767031004700 dimerization interface [polypeptide binding]; other site 767031004701 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031004702 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 767031004703 SusE outer membrane protein; Region: SusE; pfam14292 767031004704 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 767031004705 starch binding site [chemical binding]; other site 767031004706 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031004707 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031004708 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004709 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 767031004710 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 767031004711 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 767031004712 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 767031004713 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 767031004714 hydrophobic ligand binding site; other site 767031004715 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 767031004716 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 767031004717 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 767031004718 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767031004719 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 767031004720 dimerization interface [polypeptide binding]; other site 767031004721 active site 767031004722 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767031004723 active site 767031004724 catalytic residues [active] 767031004725 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 767031004726 L-fucose transporter; Provisional; Region: PRK10133; cl17665 767031004727 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 767031004728 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 767031004729 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767031004730 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 767031004731 nudix motif; other site 767031004732 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 767031004733 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 767031004734 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 767031004735 TPP-binding site [chemical binding]; other site 767031004736 dimer interface [polypeptide binding]; other site 767031004737 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767031004738 PYR/PP interface [polypeptide binding]; other site 767031004739 dimer interface [polypeptide binding]; other site 767031004740 TPP binding site [chemical binding]; other site 767031004741 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767031004742 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 767031004743 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031004744 active site 767031004745 catalytic residues [active] 767031004746 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031004747 catalytic residues [active] 767031004748 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031004749 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 767031004750 Leucine rich repeat; Region: LRR_8; pfam13855 767031004751 Leucine rich repeat; Region: LRR_8; pfam13855 767031004752 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031004753 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004754 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 767031004755 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004756 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031004757 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031004758 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031004759 Iodothyronine deiodinase; Region: T4_deiodinase; pfam00837 767031004760 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 767031004761 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031004762 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031004763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767031004764 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 767031004765 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031004766 membrane protein insertase; Provisional; Region: PRK01318 767031004767 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767031004768 CTP synthetase; Validated; Region: pyrG; PRK05380 767031004769 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767031004770 Catalytic site [active] 767031004771 active site 767031004772 UTP binding site [chemical binding]; other site 767031004773 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767031004774 active site 767031004775 putative oxyanion hole; other site 767031004776 catalytic triad [active] 767031004777 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 767031004778 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 767031004779 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 767031004780 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 767031004781 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 767031004782 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 767031004783 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 767031004784 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767031004785 active site 767031004786 catalytic site [active] 767031004787 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 767031004788 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 767031004789 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767031004790 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767031004791 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767031004792 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 767031004793 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767031004794 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031004795 AAA domain; Region: AAA_28; pfam13521 767031004796 NTPase; Region: NTPase_1; cl17478 767031004797 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 767031004798 putative active site; other site 767031004799 putative metal binding residues [ion binding]; other site 767031004800 signature motif; other site 767031004801 putative triphosphate binding site [ion binding]; other site 767031004802 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767031004803 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767031004804 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767031004805 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767031004806 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767031004807 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 767031004808 catalytic site [active] 767031004809 BNR repeat-like domain; Region: BNR_2; pfam13088 767031004810 Asp-box motif; other site 767031004811 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 767031004812 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 767031004813 active site 767031004814 trimer interface [polypeptide binding]; other site 767031004815 allosteric site; other site 767031004816 active site lid [active] 767031004817 hexamer (dimer of trimers) interface [polypeptide binding]; other site 767031004818 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 767031004819 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 767031004820 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 767031004821 active site 767031004822 trimer interface [polypeptide binding]; other site 767031004823 allosteric site; other site 767031004824 active site lid [active] 767031004825 hexamer (dimer of trimers) interface [polypeptide binding]; other site 767031004826 muropeptide transporter; Reviewed; Region: ampG; PRK11902 767031004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031004828 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 767031004829 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 767031004830 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767031004831 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767031004832 HlyD family secretion protein; Region: HlyD_3; pfam13437 767031004833 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767031004834 Eukaryotic phosphomannomutase; Region: PMM; cl17107 767031004835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031004836 motif II; other site 767031004837 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 767031004838 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 767031004839 Domain of unknown function DUF59; Region: DUF59; cl00941 767031004840 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 767031004841 Walker A motif; other site 767031004842 Rubrerythrin [Energy production and conversion]; Region: COG1592 767031004843 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 767031004844 iron binding site [ion binding]; other site 767031004845 Rubrerythrin [Energy production and conversion]; Region: COG1592 767031004846 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 767031004847 binuclear metal center [ion binding]; other site 767031004848 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 767031004849 iron binding site [ion binding]; other site 767031004850 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 767031004851 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 767031004852 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 767031004853 Predicted ATPases [General function prediction only]; Region: COG1106 767031004854 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 767031004855 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 767031004856 active site 767031004857 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 767031004858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031004859 putative substrate translocation pore; other site 767031004860 dimerization interface [polypeptide binding]; other site 767031004861 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 767031004862 putative active cleft [active] 767031004863 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 767031004864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031004865 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 767031004866 Peptidase M15; Region: Peptidase_M15_3; cl01194 767031004867 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767031004868 Predicted membrane protein [Function unknown]; Region: COG2860 767031004869 UPF0126 domain; Region: UPF0126; pfam03458 767031004870 UPF0126 domain; Region: UPF0126; pfam03458 767031004871 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767031004872 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 767031004873 putative ligand binding site [chemical binding]; other site 767031004874 putative NAD binding site [chemical binding]; other site 767031004875 catalytic site [active] 767031004876 recombination factor protein RarA; Reviewed; Region: PRK13342 767031004877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031004878 Walker A motif; other site 767031004879 ATP binding site [chemical binding]; other site 767031004880 Walker B motif; other site 767031004881 arginine finger; other site 767031004882 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767031004883 competence damage-inducible protein A; Provisional; Region: PRK01215 767031004884 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 767031004885 cell division protein FtsN; Provisional; Region: PRK12757 767031004886 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767031004887 AAA domain; Region: AAA_31; pfam13614 767031004888 P-loop; other site 767031004889 Magnesium ion binding site [ion binding]; other site 767031004890 aspartate aminotransferase; Provisional; Region: PRK05764 767031004891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767031004892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031004893 homodimer interface [polypeptide binding]; other site 767031004894 catalytic residue [active] 767031004895 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 767031004896 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 767031004897 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 767031004898 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 767031004899 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 767031004900 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 767031004901 PBP superfamily domain; Region: PBP_like_2; pfam12849 767031004902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031004903 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767031004904 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031004905 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 767031004906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031004907 FeS/SAM binding site; other site 767031004908 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 767031004909 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767031004910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031004911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031004912 DNA binding residues [nucleotide binding] 767031004913 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031004914 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 767031004915 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 767031004916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031004917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767031004918 dimer interface [polypeptide binding]; other site 767031004919 phosphorylation site [posttranslational modification] 767031004920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031004921 ATP binding site [chemical binding]; other site 767031004922 Mg2+ binding site [ion binding]; other site 767031004923 G-X-G motif; other site 767031004924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767031004925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031004926 active site 767031004927 phosphorylation site [posttranslational modification] 767031004928 intermolecular recognition site; other site 767031004929 dimerization interface [polypeptide binding]; other site 767031004930 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767031004931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031004932 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031004933 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031004934 SusD family; Region: SusD; pfam07980 767031004935 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004936 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031004937 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031004938 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 767031004939 putative substrate binding site [chemical binding]; other site 767031004940 active site 767031004941 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 767031004942 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 767031004943 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 767031004944 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 767031004945 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 767031004946 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 767031004947 putative substrate binding site [chemical binding]; other site 767031004948 active site 767031004949 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767031004950 active site 767031004951 catalytic residues [active] 767031004952 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 767031004953 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 767031004954 putative active site [active] 767031004955 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767031004956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031004957 Walker A/P-loop; other site 767031004958 ATP binding site [chemical binding]; other site 767031004959 Q-loop/lid; other site 767031004960 ABC transporter signature motif; other site 767031004961 Walker B; other site 767031004962 D-loop; other site 767031004963 H-loop/switch region; other site 767031004964 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004965 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004966 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 767031004967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767031004968 FeS/SAM binding site; other site 767031004969 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767031004970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767031004971 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767031004972 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004973 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004974 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 767031004975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031004976 S-adenosylmethionine binding site [chemical binding]; other site 767031004977 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767031004978 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 767031004979 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031004980 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031004981 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031004982 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031004983 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031004984 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 767031004985 active site 767031004986 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767031004987 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 767031004988 putative active site [active] 767031004989 putative catalytic site [active] 767031004990 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 767031004991 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 767031004992 RNA binding site [nucleotide binding]; other site 767031004993 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767031004994 RNA binding site [nucleotide binding]; other site 767031004995 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767031004996 RNA binding site [nucleotide binding]; other site 767031004997 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767031004998 RNA binding site [nucleotide binding]; other site 767031004999 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 767031005000 RNA binding site [nucleotide binding]; other site 767031005001 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 767031005002 RNA binding site [nucleotide binding]; other site 767031005003 Family of unknown function (DUF490); Region: DUF490; pfam04357 767031005004 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 767031005005 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 767031005006 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 767031005007 FMN-binding domain; Region: FMN_bind; cl01081 767031005008 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 767031005009 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 767031005010 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 767031005011 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 767031005012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767031005013 catalytic loop [active] 767031005014 iron binding site [ion binding]; other site 767031005015 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 767031005016 FAD binding pocket [chemical binding]; other site 767031005017 FAD binding motif [chemical binding]; other site 767031005018 phosphate binding motif [ion binding]; other site 767031005019 beta-alpha-beta structure motif; other site 767031005020 NAD binding pocket [chemical binding]; other site 767031005021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767031005022 DNA binding site [nucleotide binding] 767031005023 domain linker motif; other site 767031005024 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 767031005025 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767031005026 ligand binding site [chemical binding]; other site 767031005027 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 767031005028 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 767031005029 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031005030 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031005031 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005032 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 767031005033 FeoA domain; Region: FeoA; pfam04023 767031005034 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767031005035 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767031005036 G1 box; other site 767031005037 GTP/Mg2+ binding site [chemical binding]; other site 767031005038 Switch I region; other site 767031005039 G2 box; other site 767031005040 G3 box; other site 767031005041 Switch II region; other site 767031005042 G4 box; other site 767031005043 G5 box; other site 767031005044 Nucleoside recognition; Region: Gate; pfam07670 767031005045 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 767031005046 Nucleoside recognition; Region: Gate; pfam07670 767031005047 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767031005048 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767031005049 active site 767031005050 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767031005051 active site 767031005052 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767031005053 putative Zn-ribbon RNA-binding protein; Provisional; Region: PRK14890 767031005054 cytidylate kinase; Provisional; Region: cmk; PRK00023 767031005055 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767031005056 CMP-binding site; other site 767031005057 The sites determining sugar specificity; other site 767031005058 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 767031005059 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031005061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767031005062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 767031005063 active site 767031005064 phosphorylation site [posttranslational modification] 767031005065 intermolecular recognition site; other site 767031005066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767031005067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767031005068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767031005069 ATP binding site [chemical binding]; other site 767031005070 Mg2+ binding site [ion binding]; other site 767031005071 G-X-G motif; other site 767031005072 multiple promoter invertase; Provisional; Region: mpi; PRK13413 767031005073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767031005074 catalytic residues [active] 767031005075 catalytic nucleophile [active] 767031005076 Presynaptic Site I dimer interface [polypeptide binding]; other site 767031005077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767031005078 Synaptic Flat tetramer interface [polypeptide binding]; other site 767031005079 Synaptic Site I dimer interface [polypeptide binding]; other site 767031005080 DNA binding site [nucleotide binding] 767031005081 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767031005082 DNA-binding interface [nucleotide binding]; DNA binding site 767031005083 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767031005084 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 767031005085 AAA domain; Region: AAA_14; pfam13173 767031005086 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 767031005087 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767031005088 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 767031005089 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 767031005090 PLD-like domain; Region: PLDc_2; pfam13091 767031005091 putative homodimer interface [polypeptide binding]; other site 767031005092 putative active site [active] 767031005093 catalytic site [active] 767031005094 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767031005095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767031005096 putative Mg++ binding site [ion binding]; other site 767031005097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031005098 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 767031005099 nucleotide binding region [chemical binding]; other site 767031005100 ATP-binding site [chemical binding]; other site 767031005101 CAAX protease self-immunity; Region: Abi; pfam02517 767031005102 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767031005103 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767031005104 active site 767031005105 Riboflavin kinase; Region: Flavokinase; pfam01687 767031005106 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767031005107 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767031005108 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 767031005109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767031005110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767031005111 NAD(P) binding site [chemical binding]; other site 767031005112 active site 767031005113 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 767031005114 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767031005115 dimer interface [polypeptide binding]; other site 767031005116 active site 767031005117 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 767031005118 O-methyltransferase; Region: Methyltransf_2; pfam00891 767031005119 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 767031005120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 767031005121 putative acyl-acceptor binding pocket; other site 767031005122 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 767031005123 active site 2 [active] 767031005124 active site 1 [active] 767031005125 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767031005126 active site 767031005127 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 767031005128 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 767031005129 active site 767031005130 Phosphopantetheine attachment site; Region: PP-binding; cl09936 767031005131 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767031005132 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 767031005133 dimer interface [polypeptide binding]; other site 767031005134 active site 767031005135 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 767031005136 active site 767031005137 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 767031005138 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 767031005139 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 767031005140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031005141 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 767031005142 Ligand binding site; other site 767031005143 Putative Catalytic site; other site 767031005144 DXD motif; other site 767031005145 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767031005146 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767031005147 putative acyl-acceptor binding pocket; other site 767031005148 carotene isomerase; Region: carot_isom; TIGR02730 767031005149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767031005150 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 767031005151 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 767031005152 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 767031005153 substrate binding pocket [chemical binding]; other site 767031005154 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767031005155 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767031005156 putative acyl-acceptor binding pocket; other site 767031005157 Predicted exporter [General function prediction only]; Region: COG4258 767031005158 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767031005159 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767031005160 putative acyl-acceptor binding pocket; other site 767031005161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 767031005162 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 767031005163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031005164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767031005165 acyl-activating enzyme (AAE) consensus motif; other site 767031005166 acyl-activating enzyme (AAE) consensus motif; other site 767031005167 AMP binding site [chemical binding]; other site 767031005168 active site 767031005169 CoA binding site [chemical binding]; other site 767031005170 M6 family metalloprotease domain; Region: M6dom_TIGR03296 767031005171 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 767031005172 NigD-like protein; Region: NigD; pfam12667 767031005173 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767031005174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031005175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031005176 DNA binding residues [nucleotide binding] 767031005177 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 767031005178 muropeptide transporter; Reviewed; Region: ampG; PRK11902 767031005179 muropeptide transporter; Validated; Region: ampG; cl17669 767031005180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031005181 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 767031005182 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767031005183 minor groove reading motif; other site 767031005184 helix-hairpin-helix signature motif; other site 767031005185 substrate binding pocket [chemical binding]; other site 767031005186 active site 767031005187 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 767031005188 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 767031005189 DNA binding and oxoG recognition site [nucleotide binding] 767031005190 NADH dehydrogenase subunit G; Validated; Region: PRK08493 767031005191 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767031005192 purine monophosphate binding site [chemical binding]; other site 767031005193 dimer interface [polypeptide binding]; other site 767031005194 putative catalytic residues [active] 767031005195 rod shape-determining protein MreB; Provisional; Region: PRK13927 767031005196 MreB and similar proteins; Region: MreB_like; cd10225 767031005197 nucleotide binding site [chemical binding]; other site 767031005198 Mg binding site [ion binding]; other site 767031005199 putative protofilament interaction site [polypeptide binding]; other site 767031005200 RodZ interaction site [polypeptide binding]; other site 767031005201 rod shape-determining protein MreC; Provisional; Region: PRK13922 767031005202 rod shape-determining protein MreC; Region: MreC; pfam04085 767031005203 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767031005204 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 767031005205 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767031005206 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767031005207 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 767031005208 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 767031005209 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 767031005210 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767031005211 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767031005212 substrate binding pocket [chemical binding]; other site 767031005213 chain length determination region; other site 767031005214 substrate-Mg2+ binding site; other site 767031005215 catalytic residues [active] 767031005216 aspartate-rich region 1; other site 767031005217 active site lid residues [active] 767031005218 aspartate-rich region 2; other site 767031005219 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767031005220 active site 767031005221 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767031005222 Zn2+ binding site [ion binding]; other site 767031005223 Mg2+ binding site [ion binding]; other site 767031005224 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 767031005225 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 767031005226 active site 767031005227 metal binding site [ion binding]; metal-binding site 767031005228 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 767031005229 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 767031005230 E3 interaction surface; other site 767031005231 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 767031005232 active site 767031005233 dimer interface [polypeptide binding]; other site 767031005234 metal binding site [ion binding]; metal-binding site 767031005235 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 767031005236 starch binding outer membrane protein SusD; Region: SusD; cl17845 767031005237 SusD family; Region: SusD; pfam07980 767031005238 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031005239 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005240 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031005241 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031005242 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 767031005243 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 767031005244 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767031005245 sugar binding site [chemical binding]; other site 767031005246 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767031005247 sugar binding site [chemical binding]; other site 767031005248 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 767031005249 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 767031005250 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 767031005251 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 767031005252 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 767031005253 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 767031005254 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 767031005255 active site 767031005256 PHP Thumb interface [polypeptide binding]; other site 767031005257 metal binding site [ion binding]; metal-binding site 767031005258 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767031005259 generic binding surface II; other site 767031005260 generic binding surface I; other site 767031005261 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767031005262 catalytic residues [active] 767031005263 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 767031005264 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767031005265 Int/Topo IB signature motif; other site 767031005266 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 767031005267 PcfK-like protein; Region: PcfK; pfam14058 767031005268 PcfJ-like protein; Region: PcfJ; pfam14284 767031005269 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 767031005270 catalytic residue [active] 767031005271 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 767031005272 Conjugative transposon protein TraO; Region: TraO; pfam10626 767031005273 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 767031005274 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 767031005275 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 767031005276 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 767031005277 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 767031005278 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 767031005279 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 767031005280 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 767031005281 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 767031005282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767031005283 Walker A/P-loop; other site 767031005284 ATP binding site [chemical binding]; other site 767031005285 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 767031005286 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031005287 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031005288 AAA domain; Region: AAA_31; pfam13614 767031005289 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767031005290 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 767031005291 YWFCY protein; Region: YWFCY; pfam14293 767031005292 AAA-like domain; Region: AAA_10; pfam12846 767031005293 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 767031005294 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031005295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031005296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767031005297 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767031005298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767031005299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767031005300 DNA binding residues [nucleotide binding] 767031005301 dimerization interface [polypeptide binding]; other site 767031005302 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 767031005303 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 767031005304 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767031005305 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767031005306 DNA topoisomerase III; Provisional; Region: PRK07726 767031005307 active site 767031005308 putative interdomain interaction site [polypeptide binding]; other site 767031005309 putative metal-binding site [ion binding]; other site 767031005310 putative nucleotide binding site [chemical binding]; other site 767031005311 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767031005312 domain I; other site 767031005313 DNA binding groove [nucleotide binding] 767031005314 phosphate binding site [ion binding]; other site 767031005315 domain II; other site 767031005316 domain III; other site 767031005317 nucleotide binding site [chemical binding]; other site 767031005318 catalytic site [active] 767031005319 domain IV; other site 767031005320 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767031005321 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767031005322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031005323 S-adenosylmethionine binding site [chemical binding]; other site 767031005324 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 767031005325 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 767031005326 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767031005327 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 767031005328 helicase superfamily c-terminal domain; Region: HELICc; smart00490 767031005329 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 767031005330 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 767031005331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 767031005332 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 767031005333 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031005334 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 767031005335 active site 767031005336 metal binding site [ion binding]; metal-binding site 767031005337 interdomain interaction site; other site 767031005338 AAA domain; Region: AAA_25; pfam13481 767031005339 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767031005340 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 767031005341 Sporulation related domain; Region: SPOR; pfam05036 767031005342 phosphopeptide binding site; other site 767031005343 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 767031005344 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 767031005345 starch binding outer membrane protein SusD; Region: SusD; cd08977 767031005346 Secretin and TonB N terminus short domain; Region: STN; pfam07660 767031005347 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 767031005348 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005349 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031005350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031005351 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 767031005352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031005353 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031005354 DNA binding residues [nucleotide binding] 767031005355 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 767031005356 FecR protein; Region: FecR; pfam04773 767031005357 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 767031005358 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767031005359 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767031005360 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767031005361 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 767031005362 Histidine kinase; Region: His_kinase; pfam06580 767031005363 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 767031005364 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767031005365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767031005366 active site 767031005367 phosphorylation site [posttranslational modification] 767031005368 intermolecular recognition site; other site 767031005369 dimerization interface [polypeptide binding]; other site 767031005370 LytTr DNA-binding domain; Region: LytTR; smart00850 767031005371 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 767031005372 Lumazine binding domain; Region: Lum_binding; pfam00677 767031005373 Lumazine binding domain; Region: Lum_binding; pfam00677 767031005374 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 767031005375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767031005376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767031005377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767031005378 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 767031005379 tetramer interface [polypeptide binding]; other site 767031005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031005381 catalytic residue [active] 767031005382 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 767031005383 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 767031005384 tetramer interface [polypeptide binding]; other site 767031005385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031005386 catalytic residue [active] 767031005387 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 767031005388 lipoyl attachment site [posttranslational modification]; other site 767031005389 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 767031005390 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 767031005391 FMN-binding domain; Region: FMN_bind; pfam04205 767031005392 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 767031005393 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767031005394 SdiA-regulated; Region: SdiA-regulated; cd09971 767031005395 putative active site [active] 767031005396 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 767031005397 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 767031005398 Substrate binding site; other site 767031005399 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767031005400 glutamate dehydrogenase; Provisional; Region: PRK14030 767031005401 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 767031005402 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 767031005403 NAD(P) binding site [chemical binding]; other site 767031005404 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 767031005405 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 767031005406 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767031005407 Double zinc ribbon; Region: DZR; pfam12773 767031005408 Protein of unknown function (DUF983); Region: DUF983; cl02211 767031005409 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 767031005410 nucleoside transporter; Region: 2A0110; TIGR00889 767031005411 Bifunctional nuclease; Region: DNase-RNase; cl00553 767031005412 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 767031005413 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 767031005414 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031005415 Cupin domain; Region: Cupin_2; pfam07883 767031005416 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005417 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 767031005418 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 767031005419 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767031005420 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767031005421 fumarate hydratase; Provisional; Region: PRK15389 767031005422 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 767031005423 Fumarase C-terminus; Region: Fumerase_C; pfam05683 767031005424 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031005425 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767031005426 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031005427 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767031005428 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767031005429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767031005430 putative trimer interface [polypeptide binding]; other site 767031005431 putative CoA binding site [chemical binding]; other site 767031005432 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767031005433 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767031005434 HflX GTPase family; Region: HflX; cd01878 767031005435 G1 box; other site 767031005436 GTP/Mg2+ binding site [chemical binding]; other site 767031005437 Switch I region; other site 767031005438 G2 box; other site 767031005439 G3 box; other site 767031005440 Switch II region; other site 767031005441 G4 box; other site 767031005442 G5 box; other site 767031005443 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 767031005444 Cna protein B-type domain; Region: Cna_B_2; pfam13715 767031005445 GldH lipoprotein; Region: GldH_lipo; pfam14109 767031005446 PSP1 C-terminal conserved region; Region: PSP1; cl00770 767031005447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767031005448 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 767031005449 Walker A motif; other site 767031005450 ATP binding site [chemical binding]; other site 767031005451 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767031005452 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031005453 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031005454 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031005455 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 767031005456 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767031005457 active site 767031005458 catalytic residues [active] 767031005459 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 767031005460 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 767031005461 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 767031005462 ligand binding site [chemical binding]; other site 767031005463 DNA recombination protein RmuC; Provisional; Region: PRK10361 767031005464 RmuC family; Region: RmuC; pfam02646 767031005465 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 767031005466 additional DNA contacts [nucleotide binding]; other site 767031005467 mismatch recognition site; other site 767031005468 active site 767031005469 zinc binding site [ion binding]; other site 767031005470 DNA intercalation site [nucleotide binding]; other site 767031005471 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 767031005472 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031005473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031005474 ABC transporter; Region: ABC_tran_2; pfam12848 767031005475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767031005476 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767031005477 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767031005478 thymidine kinase; Provisional; Region: PRK04296 767031005479 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031005480 active site 767031005481 DNA binding site [nucleotide binding] 767031005482 Int/Topo IB signature motif; other site 767031005483 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767031005484 dimerization interface [polypeptide binding]; other site 767031005485 active site 767031005486 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 767031005487 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 767031005488 TIR domain; Region: TIR_2; pfam13676 767031005489 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031005490 RteC protein; Region: RteC; pfam09357 767031005491 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767031005492 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767031005493 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767031005494 Helix-turn-helix domain; Region: HTH_18; pfam12833 767031005495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767031005496 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767031005497 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767031005498 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 767031005499 Int/Topo IB signature motif; other site 767031005500 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 767031005501 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767031005502 Int/Topo IB signature motif; other site 767031005503 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767031005504 active site 767031005505 Int/Topo IB signature motif; other site 767031005506 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 767031005507 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767031005508 DNA methylase; Region: N6_N4_Mtase; pfam01555 767031005509 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 767031005510 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767031005511 FMN binding site [chemical binding]; other site 767031005512 dimer interface [polypeptide binding]; other site 767031005513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767031005514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767031005515 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 767031005516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767031005517 putative metal binding site [ion binding]; other site 767031005518 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031005519 Helix-turn-helix domain; Region: HTH_17; pfam12728 767031005520 Virulence-associated protein E; Region: VirE; pfam05272 767031005521 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 767031005522 Toprim-like; Region: Toprim_2; pfam13155 767031005523 active site 767031005524 metal binding site [ion binding]; metal-binding site 767031005525 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 767031005526 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 767031005527 Predicted methyltransferases [General function prediction only]; Region: COG0313 767031005528 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767031005529 putative SAM binding site [chemical binding]; other site 767031005530 putative homodimer interface [polypeptide binding]; other site 767031005531 chromosome segregation protein; Provisional; Region: PRK01156 767031005532 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767031005533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031005534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031005535 DNA binding residues [nucleotide binding] 767031005536 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 767031005537 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767031005538 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767031005539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767031005540 active site 767031005541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767031005542 dimer interface [polypeptide binding]; other site 767031005543 substrate binding site [chemical binding]; other site 767031005544 catalytic residues [active] 767031005545 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 767031005546 metal binding site 2 [ion binding]; metal-binding site 767031005547 putative DNA binding helix; other site 767031005548 metal binding site 1 [ion binding]; metal-binding site 767031005549 dimer interface [polypeptide binding]; other site 767031005550 structural Zn2+ binding site [ion binding]; other site 767031005551 GSCFA family; Region: GSCFA; pfam08885 767031005552 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 767031005553 nudix motif; other site 767031005554 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 767031005555 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 767031005556 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 767031005557 putative ligand binding site [chemical binding]; other site 767031005558 Phosphotransferase enzyme family; Region: APH; pfam01636 767031005559 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 767031005560 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 767031005561 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 767031005562 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 767031005563 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 767031005564 active site 767031005565 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767031005566 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 767031005567 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 767031005568 Domain of unknown function (DUF377); Region: DUF377; pfam04041 767031005569 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 767031005570 active site 767031005571 Thiamine pyrophosphokinase; Region: TPK; cd07995 767031005572 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 767031005573 active site 767031005574 dimerization interface [polypeptide binding]; other site 767031005575 thiamine binding site [chemical binding]; other site 767031005576 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 767031005577 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 767031005578 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 767031005579 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767031005580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031005581 S-adenosylmethionine binding site [chemical binding]; other site 767031005582 pyruvate phosphate dikinase; Provisional; Region: PRK09279 767031005583 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767031005584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767031005585 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767031005586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 767031005587 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767031005588 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767031005589 putative tRNA-binding site [nucleotide binding]; other site 767031005590 B3/4 domain; Region: B3_4; pfam03483 767031005591 tRNA synthetase B5 domain; Region: B5; smart00874 767031005592 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767031005593 dimer interface [polypeptide binding]; other site 767031005594 motif 1; other site 767031005595 motif 3; other site 767031005596 motif 2; other site 767031005597 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 767031005598 hypothetical protein; Provisional; Region: PRK12378 767031005599 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 767031005600 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 767031005601 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 767031005602 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767031005603 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767031005604 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767031005605 Transglycosylase; Region: Transgly; pfam00912 767031005606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767031005607 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 767031005608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767031005609 FtsX-like permease family; Region: FtsX; pfam02687 767031005610 aspartate aminotransferase; Provisional; Region: PRK07568 767031005611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767031005612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031005613 homodimer interface [polypeptide binding]; other site 767031005614 catalytic residue [active] 767031005615 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 767031005616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767031005617 catalytic residue [active] 767031005618 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 767031005619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767031005620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767031005621 homodimer interface [polypeptide binding]; other site 767031005622 catalytic residue [active] 767031005623 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767031005624 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767031005625 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 767031005626 Surface antigen; Region: Bac_surface_Ag; pfam01103 767031005627 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767031005628 Rubredoxin [Energy production and conversion]; Region: COG1773 767031005629 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 767031005630 iron binding site [ion binding]; other site 767031005631 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 767031005632 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767031005633 SmpB-tmRNA interface; other site 767031005634 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767031005635 active site 767031005636 UGMP family protein; Validated; Region: PRK09604 767031005637 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767031005638 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 767031005639 Competence-damaged protein; Region: CinA; pfam02464 767031005640 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767031005641 ribosomal protein L33; Region: rpl33; CHL00104 767031005642 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 767031005643 Flavodoxin domain; Region: Flavodoxin_5; cl17428 767031005644 Ferredoxin [Energy production and conversion]; Region: COG1146 767031005645 4Fe-4S binding domain; Region: Fer4; pfam00037 767031005646 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767031005647 Competence protein; Region: Competence; pfam03772 767031005648 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767031005649 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767031005650 dimerization interface 3.5A [polypeptide binding]; other site 767031005651 active site 767031005652 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767031005653 dihydrodipicolinate synthase; Region: dapA; TIGR00674 767031005654 dimer interface [polypeptide binding]; other site 767031005655 active site 767031005656 catalytic residue [active] 767031005657 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767031005658 active site 767031005659 dimer interface [polypeptide binding]; other site 767031005660 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767031005661 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767031005662 RF-1 domain; Region: RF-1; pfam00472 767031005663 Protein of unknown function (DUF511); Region: DUF511; cl01114 767031005664 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 767031005665 dimerization interface [polypeptide binding]; other site 767031005666 ATP binding site [chemical binding]; other site 767031005667 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 767031005668 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 767031005669 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 767031005670 Ligand binding site; other site 767031005671 oligomer interface; other site 767031005672 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 767031005673 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 767031005674 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 767031005675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031005676 active site 767031005677 motif I; other site 767031005678 motif II; other site 767031005679 Maf-like protein; Region: Maf; pfam02545 767031005680 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 767031005681 active site 767031005682 dimer interface [polypeptide binding]; other site 767031005683 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767031005684 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 767031005685 Phosphoglycerate kinase; Region: PGK; pfam00162 767031005686 substrate binding site [chemical binding]; other site 767031005687 hinge regions; other site 767031005688 ADP binding site [chemical binding]; other site 767031005689 catalytic site [active] 767031005690 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 767031005691 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 767031005692 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767031005693 Ligand binding site; other site 767031005694 Putative Catalytic site; other site 767031005695 DXD motif; other site 767031005696 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767031005697 ApbE family; Region: ApbE; pfam02424 767031005698 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767031005699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767031005700 ligand binding site [chemical binding]; other site 767031005701 flexible hinge region; other site 767031005702 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 767031005703 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 767031005704 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 767031005705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031005706 S-adenosylmethionine binding site [chemical binding]; other site 767031005707 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 767031005708 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 767031005709 active site 767031005710 ADP/pyrophosphate binding site [chemical binding]; other site 767031005711 dimerization interface [polypeptide binding]; other site 767031005712 allosteric effector site; other site 767031005713 fructose-1,6-bisphosphate binding site; other site 767031005714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 767031005715 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767031005716 putative acyl-acceptor binding pocket; other site 767031005717 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 767031005718 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 767031005719 active site 767031005720 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 767031005721 Interdomain contacts; other site 767031005722 Cytokine receptor motif; other site 767031005723 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 767031005724 hypothetical protein; Provisional; Region: PRK00955 767031005725 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 767031005726 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 767031005727 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767031005728 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767031005729 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 767031005730 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767031005731 carboxyltransferase (CT) interaction site; other site 767031005732 biotinylation site [posttranslational modification]; other site 767031005733 UDP-glucose 4-epimerase; Region: PLN02240 767031005734 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767031005735 NAD binding site [chemical binding]; other site 767031005736 homodimer interface [polypeptide binding]; other site 767031005737 active site 767031005738 substrate binding site [chemical binding]; other site 767031005739 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 767031005740 transcription termination factor Rho; Provisional; Region: PRK12608 767031005741 RNA binding site [nucleotide binding]; other site 767031005742 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 767031005743 multimer interface [polypeptide binding]; other site 767031005744 Walker A motif; other site 767031005745 ATP binding site [chemical binding]; other site 767031005746 Walker B motif; other site 767031005747 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 767031005748 HD domain; Region: HD_4; pfam13328 767031005749 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767031005750 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767031005751 synthetase active site [active] 767031005752 NTP binding site [chemical binding]; other site 767031005753 metal binding site [ion binding]; metal-binding site 767031005754 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767031005755 ACT domain; Region: ACT_4; pfam13291 767031005756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031005757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767031005758 putative substrate translocation pore; other site 767031005759 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 767031005760 oligomerization interface [polypeptide binding]; other site 767031005761 active site 767031005762 metal binding site [ion binding]; metal-binding site 767031005763 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 767031005764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767031005765 motif II; other site 767031005766 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 767031005767 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767031005768 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 767031005769 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 767031005770 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 767031005771 active site 767031005772 putative DNA-binding cleft [nucleotide binding]; other site 767031005773 dimer interface [polypeptide binding]; other site 767031005774 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767031005775 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767031005776 Ligand Binding Site [chemical binding]; other site 767031005777 TilS substrate C-terminal domain; Region: TilS_C; smart00977 767031005778 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 767031005779 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 767031005780 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 767031005781 putative RNA binding site [nucleotide binding]; other site 767031005782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767031005783 S-adenosylmethionine binding site [chemical binding]; other site 767031005784 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 767031005785 catalytic site [active] 767031005786 putative active site [active] 767031005787 putative substrate binding site [chemical binding]; other site 767031005788 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767031005789 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767031005790 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767031005791 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 767031005792 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 767031005793 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 767031005794 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 767031005795 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 767031005796 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 767031005797 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 767031005798 CRISPR-associated protein; Region: TIGR03986 767031005799 RAMP superfamily; Region: RAMPs; pfam03787 767031005800 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 767031005801 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 767031005802 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 767031005803 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 767031005804 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 767031005805 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 767031005806 VirE N-terminal domain; Region: VirE_N; pfam08800 767031005807 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 767031005808 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767031005809 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 767031005810 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 767031005811 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767031005812 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767031005813 active site 767031005814 dimer interface [polypeptide binding]; other site 767031005815 motif 1; other site 767031005816 motif 2; other site 767031005817 motif 3; other site 767031005818 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767031005819 anticodon binding site; other site 767031005820 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 767031005821 tetramerization interface [polypeptide binding]; other site 767031005822 active site 767031005823 Pantoate-beta-alanine ligase; Region: PanC; cd00560 767031005824 pantoate--beta-alanine ligase; Region: panC; TIGR00018 767031005825 active site 767031005826 ATP-binding site [chemical binding]; other site 767031005827 pantoate-binding site; other site 767031005828 HXXH motif; other site 767031005829 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 767031005830 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 767031005831 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767031005832 Clp amino terminal domain; Region: Clp_N; pfam02861 767031005833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031005834 Walker A motif; other site 767031005835 ATP binding site [chemical binding]; other site 767031005836 Walker B motif; other site 767031005837 arginine finger; other site 767031005838 UvrB/uvrC motif; Region: UVR; pfam02151 767031005839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767031005840 Walker A motif; other site 767031005841 ATP binding site [chemical binding]; other site 767031005842 Walker B motif; other site 767031005843 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767031005844 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 767031005845 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 767031005846 active site 767031005847 substrate binding site [chemical binding]; other site 767031005848 metal binding site [ion binding]; metal-binding site 767031005849 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 767031005850 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767031005851 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767031005852 dimer interface [polypeptide binding]; other site 767031005853 anticodon binding site; other site 767031005854 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767031005855 homodimer interface [polypeptide binding]; other site 767031005856 motif 1; other site 767031005857 active site 767031005858 motif 2; other site 767031005859 GAD domain; Region: GAD; pfam02938 767031005860 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767031005861 motif 3; other site 767031005862 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 767031005863 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767031005864 active site 767031005865 catalytic triad [active] 767031005866 oxyanion hole [active] 767031005867 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 767031005868 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 767031005869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031005870 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 767031005871 LicD family; Region: LicD; pfam04991 767031005872 classical (c) SDRs; Region: SDR_c; cd05233 767031005873 NAD(P) binding site [chemical binding]; other site 767031005874 active site 767031005875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031005876 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 767031005877 active site 767031005878 nucleotide binding site [chemical binding]; other site 767031005879 HIGH motif; other site 767031005880 KMSKS motif; other site 767031005881 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767031005882 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767031005883 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 767031005884 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767031005885 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767031005886 putative ADP-binding pocket [chemical binding]; other site 767031005887 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767031005888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767031005889 active site 767031005890 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 767031005891 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767031005892 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 767031005893 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767031005894 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767031005895 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767031005896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767031005897 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767031005898 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 767031005899 active site 767031005900 homodimer interface [polypeptide binding]; other site 767031005901 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 767031005902 Class I aldolases; Region: Aldolase_Class_I; cl17187 767031005903 catalytic residue [active] 767031005904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767031005905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767031005906 putative substrate translocation pore; other site 767031005907 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 767031005908 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767031005909 active site 767031005910 catalytic triad [active] 767031005911 oxyanion hole [active] 767031005912 Domain of unknown function (DUF303); Region: DUF303; pfam03629 767031005913 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 767031005914 catalytic triad [active] 767031005915 active site nucleophile [active] 767031005916 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 767031005917 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767031005918 minor groove reading motif; other site 767031005919 helix-hairpin-helix signature motif; other site 767031005920 substrate binding pocket [chemical binding]; other site 767031005921 active site 767031005922 TIGR02453 family protein; Region: TIGR02453 767031005923 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767031005924 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031005925 active site 767031005926 HIGH motif; other site 767031005927 nucleotide binding site [chemical binding]; other site 767031005928 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767031005929 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767031005930 active site 767031005931 KMSKS motif; other site 767031005932 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767031005933 tRNA binding surface [nucleotide binding]; other site 767031005934 anticodon binding site; other site 767031005935 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767031005936 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 767031005937 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 767031005938 homodimer interface [polypeptide binding]; other site 767031005939 metal binding site [ion binding]; metal-binding site 767031005940 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 767031005941 homodimer interface [polypeptide binding]; other site 767031005942 active site 767031005943 putative chemical substrate binding site [chemical binding]; other site 767031005944 metal binding site [ion binding]; metal-binding site 767031005945 Lipocalin-like; Region: Lipocalin_3; pfam12702 767031005946 ribonuclease Z; Region: RNase_Z; TIGR02651 767031005947 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 767031005948 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 767031005949 putative catalytic residues [active] 767031005950 putative nucleotide binding site [chemical binding]; other site 767031005951 putative aspartate binding site [chemical binding]; other site 767031005952 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 767031005953 dimer interface [polypeptide binding]; other site 767031005954 putative threonine allosteric regulatory site; other site 767031005955 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 767031005956 putative threonine allosteric regulatory site; other site 767031005957 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767031005958 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767031005959 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 767031005960 Predicted membrane protein [Function unknown]; Region: COG3059 767031005961 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 767031005962 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 767031005963 active site 767031005964 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767031005965 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 767031005966 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 767031005967 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 767031005968 catalytic core [active] 767031005969 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 767031005970 Flavin Reductases; Region: FlaRed; cl00801 767031005971 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767031005972 metal binding site 2 [ion binding]; metal-binding site 767031005973 putative DNA binding helix; other site 767031005974 metal binding site 1 [ion binding]; metal-binding site 767031005975 dimer interface [polypeptide binding]; other site 767031005976 structural Zn2+ binding site [ion binding]; other site 767031005977 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 767031005978 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031005979 active site 767031005980 HIGH motif; other site 767031005981 nucleotide binding site [chemical binding]; other site 767031005982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031005983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031005984 active site 767031005985 KMSKS motif; other site 767031005986 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 767031005987 tRNA binding surface [nucleotide binding]; other site 767031005988 anticodon binding site; other site 767031005989 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 767031005990 lipoprotein signal peptidase; Provisional; Region: PRK14788 767031005991 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 767031005992 Peptidase family M23; Region: Peptidase_M23; pfam01551 767031005993 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767031005994 Peptidase family C69; Region: Peptidase_C69; cl17793 767031005995 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767031005996 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767031005997 Uncharacterized conserved protein [Function unknown]; Region: COG4198 767031005998 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 767031005999 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 767031006000 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767031006001 putative ligand binding site [chemical binding]; other site 767031006002 putative NAD binding site [chemical binding]; other site 767031006003 putative catalytic site [active] 767031006004 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 767031006005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767031006006 catalytic residue [active] 767031006007 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 767031006008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767031006009 ATP binding site [chemical binding]; other site 767031006010 putative Mg++ binding site [ion binding]; other site 767031006011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767031006012 nucleotide binding region [chemical binding]; other site 767031006013 ATP-binding site [chemical binding]; other site 767031006014 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 767031006015 RNA binding site [nucleotide binding]; other site 767031006016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031006017 binding surface 767031006018 TPR motif; other site 767031006019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031006020 TPR motif; other site 767031006021 TPR repeat; Region: TPR_11; pfam13414 767031006022 binding surface 767031006023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767031006024 binding surface 767031006025 TPR motif; other site 767031006026 DNA gyrase subunit A; Validated; Region: PRK05560 767031006027 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767031006028 CAP-like domain; other site 767031006029 active site 767031006030 primary dimer interface [polypeptide binding]; other site 767031006031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767031006037 replicative DNA helicase; Region: DnaB; TIGR00665 767031006038 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767031006039 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767031006040 Walker A motif; other site 767031006041 ATP binding site [chemical binding]; other site 767031006042 Walker B motif; other site 767031006043 DNA binding loops [nucleotide binding] 767031006044 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 767031006045 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767031006046 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767031006047 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 767031006048 Family description; Region: UvrD_C_2; pfam13538 767031006049 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 767031006050 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767031006051 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 767031006052 Part of AAA domain; Region: AAA_19; pfam13245 767031006053 Family description; Region: UvrD_C_2; pfam13538 767031006054 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 767031006055 Transglycosylase; Region: Transgly; cl17702 767031006056 Surface antigen; Region: Bac_surface_Ag; pfam01103 767031006057 Family of unknown function (DUF490); Region: DUF490; pfam04357 767031006058 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 767031006059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767031006060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767031006061 DNA binding residues [nucleotide binding] 767031006062 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767031006063 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767031006064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031006065 TPR motif; other site 767031006066 binding surface 767031006067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767031006068 binding surface 767031006069 TPR motif; other site 767031006070 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 767031006071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767031006072 active site 767031006073 HIGH motif; other site 767031006074 nucleotide binding site [chemical binding]; other site 767031006075 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 767031006076 KMSKS motif; other site 767031006077 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 767031006078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767031006079 catalytic core [active] 767031006080 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 767031006081 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 767031006082 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 767031006083 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767031006084 DNA binding site [nucleotide binding] 767031006085 active site 767031006086 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 767031006087 dimer interface [polypeptide binding]; other site 767031006088 FMN binding site [chemical binding]; other site 767031006089 NADPH bind site [chemical binding]; other site 767031006090 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 767031006091 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 767031006092 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 767031006093 active site 767031006094 dimer interface [polypeptide binding]; other site 767031006095 effector binding site; other site 767031006096 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767031006097 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 767031006098 homooctamer interface [polypeptide binding]; other site 767031006099 active site 767031006100 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767031006101 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767031006102 active site 767031006103 metal binding site [ion binding]; metal-binding site 767031006104 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 767031006105 mce related protein; Region: MCE; pfam02470