-- dump date   	20140619_235535
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
553174000001	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
553174000002	Right handed beta helix region; Region: Beta_helix; pfam13229
553174000003	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
553174000004	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
553174000005	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
553174000006	dimerization interface [polypeptide binding]; other site
553174000007	active site
553174000008	metal binding site [ion binding]; metal-binding site
553174000009	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
553174000010	dsRNA binding site [nucleotide binding]; other site
553174000011	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
553174000012	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
553174000013	dimer interface [polypeptide binding]; other site
553174000014	active site
553174000015	acyl carrier protein; Provisional; Region: acpP; PRK00982
553174000016	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
553174000017	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
553174000018	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174000019	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
553174000020	putative active site [active]
553174000021	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364
553174000022	ATP cone domain; Region: ATP-cone; pfam03477
553174000023	Class I ribonucleotide reductase; Region: RNR_I; cd01679
553174000024	active site
553174000025	dimer interface [polypeptide binding]; other site
553174000026	catalytic residues [active]
553174000027	effector binding site; other site
553174000028	R2 peptide binding site; other site
553174000029	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
553174000030	dimer interface [polypeptide binding]; other site
553174000031	putative radical transfer pathway; other site
553174000032	diiron center [ion binding]; other site
553174000033	tyrosyl radical; other site
553174000034	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
553174000035	GTP-binding protein YchF; Reviewed; Region: PRK09601
553174000036	YchF GTPase; Region: YchF; cd01900
553174000037	G1 box; other site
553174000038	GTP/Mg2+ binding site [chemical binding]; other site
553174000039	Switch I region; other site
553174000040	G2 box; other site
553174000041	Switch II region; other site
553174000042	G3 box; other site
553174000043	G4 box; other site
553174000044	G5 box; other site
553174000045	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
553174000046	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
553174000047	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
553174000048	MutS domain I; Region: MutS_I; pfam01624
553174000049	MutS domain II; Region: MutS_II; pfam05188
553174000050	MutS domain III; Region: MutS_III; pfam05192
553174000051	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
553174000052	Walker A/P-loop; other site
553174000053	ATP binding site [chemical binding]; other site
553174000054	Q-loop/lid; other site
553174000055	ABC transporter signature motif; other site
553174000056	Walker B; other site
553174000057	D-loop; other site
553174000058	H-loop/switch region; other site
553174000059	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
553174000060	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174000061	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174000062	DNA binding residues [nucleotide binding]
553174000063	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
553174000064	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
553174000065	putative active site [active]
553174000066	putative NTP binding site [chemical binding]; other site
553174000067	putative nucleic acid binding site [nucleotide binding]; other site
553174000068	hypothetical protein; Provisional; Region: PRK07101
553174000069	substrate-cofactor binding pocket; other site
553174000070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174000071	catalytic residue [active]
553174000072	para-aminobenzoate synthase component I; Validated; Region: PRK07093
553174000073	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
553174000074	NADH(P)-binding; Region: NAD_binding_10; pfam13460
553174000075	NAD binding site [chemical binding]; other site
553174000076	active site
553174000077	Histidine kinase; Region: His_kinase; pfam06580
553174000078	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
553174000079	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
553174000080	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
553174000081	AIR carboxylase; Region: AIRC; pfam00731
553174000082	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
553174000083	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
553174000084	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
553174000085	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174000086	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174000087	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
553174000088	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174000089	active site
553174000090	HIGH motif; other site
553174000091	nucleotide binding site [chemical binding]; other site
553174000092	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
553174000093	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174000094	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174000095	active site
553174000096	KMSKS motif; other site
553174000097	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
553174000098	tRNA binding surface [nucleotide binding]; other site
553174000099	Uncharacterized conserved protein [Function unknown]; Region: COG1284
553174000100	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
553174000101	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
553174000102	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
553174000103	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
553174000104	active site
553174000105	dimerization interface [polypeptide binding]; other site
553174000106	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174000107	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
553174000108	Bacterial Ig-like domain; Region: Big_5; pfam13205
553174000109	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
553174000110	GH3 auxin-responsive promoter; Region: GH3; pfam03321
553174000111	DNA polymerase I; Provisional; Region: PRK05755
553174000112	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
553174000113	active site
553174000114	metal binding site 1 [ion binding]; metal-binding site
553174000115	putative 5' ssDNA interaction site; other site
553174000116	metal binding site 3; metal-binding site
553174000117	metal binding site 2 [ion binding]; metal-binding site
553174000118	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
553174000119	putative DNA binding site [nucleotide binding]; other site
553174000120	putative metal binding site [ion binding]; other site
553174000121	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
553174000122	active site
553174000123	catalytic site [active]
553174000124	substrate binding site [chemical binding]; other site
553174000125	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
553174000126	active site
553174000127	DNA binding site [nucleotide binding]
553174000128	catalytic site [active]
553174000129	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
553174000130	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
553174000131	substrate binding pocket [chemical binding]; other site
553174000132	chain length determination region; other site
553174000133	substrate-Mg2+ binding site; other site
553174000134	catalytic residues [active]
553174000135	aspartate-rich region 1; other site
553174000136	active site lid residues [active]
553174000137	aspartate-rich region 2; other site
553174000138	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
553174000139	intersubunit interface [polypeptide binding]; other site
553174000140	active site
553174000141	catalytic residue [active]
553174000142	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
553174000143	homodimer interface [polypeptide binding]; other site
553174000144	metal binding site [ion binding]; metal-binding site
553174000145	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
553174000146	putative active site [active]
553174000147	dimerization interface [polypeptide binding]; other site
553174000148	putative tRNAtyr binding site [nucleotide binding]; other site
553174000149	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
553174000150	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
553174000151	GIY-YIG motif/motif A; other site
553174000152	active site
553174000153	catalytic site [active]
553174000154	putative DNA binding site [nucleotide binding]; other site
553174000155	metal binding site [ion binding]; metal-binding site
553174000156	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
553174000157	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174000158	active site
553174000159	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
553174000160	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
553174000161	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
553174000162	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
553174000163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
553174000164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174000165	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
553174000166	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
553174000167	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174000168	sugar binding site [chemical binding]; other site
553174000169	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
553174000170	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
553174000171	putative Iron-sulfur protein interface [polypeptide binding]; other site
553174000172	proximal heme binding site [chemical binding]; other site
553174000173	distal heme binding site [chemical binding]; other site
553174000174	putative dimer interface [polypeptide binding]; other site
553174000175	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
553174000176	L-aspartate oxidase; Provisional; Region: PRK06175
553174000177	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
553174000178	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
553174000179	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
553174000180	Catalytic domain of Protein Kinases; Region: PKc; cd00180
553174000181	active site
553174000182	substrate binding site [chemical binding]; other site
553174000183	ATP binding site [chemical binding]; other site
553174000184	Protein kinase domain; Region: Pkinase; pfam00069
553174000185	activation loop (A-loop); other site
553174000186	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
553174000187	Methyltransferase domain; Region: Methyltransf_26; pfam13659
553174000188	Endonuclease I; Region: Endonuclease_1; cl01003
553174000189	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
553174000190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174000191	ATP binding site [chemical binding]; other site
553174000192	Mg2+ binding site [ion binding]; other site
553174000193	G-X-G motif; other site
553174000194	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
553174000195	ATP binding site [chemical binding]; other site
553174000196	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
553174000197	active site
553174000198	putative metal-binding site [ion binding]; other site
553174000199	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
553174000200	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
553174000201	C-terminal peptidase (prc); Region: prc; TIGR00225
553174000202	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
553174000203	protein binding site [polypeptide binding]; other site
553174000204	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
553174000205	Catalytic dyad [active]
553174000206	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
553174000207	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
553174000208	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174000209	active site
553174000210	nucleotide binding site [chemical binding]; other site
553174000211	HIGH motif; other site
553174000212	KMSKS motif; other site
553174000213	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
553174000214	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
553174000215	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174000216	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174000217	DNA binding residues [nucleotide binding]
553174000218	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
553174000219	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
553174000220	DNA protecting protein DprA; Region: dprA; TIGR00732
553174000221	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
553174000222	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
553174000223	active site
553174000224	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
553174000225	dihydrodipicolinate reductase; Provisional; Region: PRK00048
553174000226	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
553174000227	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
553174000228	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
553174000229	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
553174000230	Catalytic site [active]
553174000231	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
553174000232	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
553174000233	WbqC-like protein family; Region: WbqC; pfam08889
553174000234	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
553174000235	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
553174000236	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
553174000237	Aspartase; Region: Aspartase; cd01357
553174000238	active sites [active]
553174000239	tetramer interface [polypeptide binding]; other site
553174000240	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174000241	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174000242	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000243	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000244	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174000245	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174000246	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
553174000247	active site
553174000248	metal binding site [ion binding]; metal-binding site
553174000249	homotetramer interface [polypeptide binding]; other site
553174000250	Acyltransferase family; Region: Acyl_transf_3; pfam01757
553174000251	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
553174000252	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
553174000253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174000254	Walker A motif; other site
553174000255	ATP binding site [chemical binding]; other site
553174000256	Walker B motif; other site
553174000257	arginine finger; other site
553174000258	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
553174000259	Uncharacterized conserved protein [Function unknown]; Region: COG1284
553174000260	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
553174000261	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
553174000262	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
553174000263	catalytic residues [active]
553174000264	dimer interface [polypeptide binding]; other site
553174000265	NAD-dependent deacetylase; Provisional; Region: PRK00481
553174000266	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
553174000267	NAD+ binding site [chemical binding]; other site
553174000268	substrate binding site [chemical binding]; other site
553174000269	Zn binding site [ion binding]; other site
553174000270	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
553174000271	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
553174000272	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
553174000273	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
553174000274	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
553174000275	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
553174000276	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
553174000277	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
553174000278	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
553174000279	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
553174000280	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
553174000281	putative DNA binding site [nucleotide binding]; other site
553174000282	putative Zn2+ binding site [ion binding]; other site
553174000283	AsnC family; Region: AsnC_trans_reg; pfam01037
553174000284	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
553174000285	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
553174000286	catalytic triad [active]
553174000287	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
553174000288	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
553174000289	active site
553174000290	dimer interface [polypeptide binding]; other site
553174000291	M28 Zn-Peptidases; Region: M28_like_6; cd08656
553174000292	Peptidase family M28; Region: Peptidase_M28; pfam04389
553174000293	metal binding site [ion binding]; metal-binding site
553174000294	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
553174000295	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
553174000296	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
553174000297	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
553174000298	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
553174000299	Peptidase S46; Region: Peptidase_S46; pfam10459
553174000300	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
553174000301	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
553174000302	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
553174000303	DEAD-like helicases superfamily; Region: DEXDc; smart00487
553174000304	ATP binding site [chemical binding]; other site
553174000305	Mg++ binding site [ion binding]; other site
553174000306	motif III; other site
553174000307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174000308	nucleotide binding region [chemical binding]; other site
553174000309	ATP-binding site [chemical binding]; other site
553174000310	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
553174000311	RNA binding site [nucleotide binding]; other site
553174000312	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
553174000313	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
553174000314	RNase E interface [polypeptide binding]; other site
553174000315	trimer interface [polypeptide binding]; other site
553174000316	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
553174000317	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
553174000318	RNase E interface [polypeptide binding]; other site
553174000319	trimer interface [polypeptide binding]; other site
553174000320	active site
553174000321	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
553174000322	putative nucleic acid binding region [nucleotide binding]; other site
553174000323	G-X-X-G motif; other site
553174000324	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
553174000325	RNA binding site [nucleotide binding]; other site
553174000326	domain interface; other site
553174000327	Lamin Tail Domain; Region: LTD; pfam00932
553174000328	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
553174000329	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
553174000330	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174000331	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174000332	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
553174000333	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
553174000334	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
553174000335	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174000336	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
553174000337	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174000338	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
553174000339	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
553174000340	putative substrate binding site [chemical binding]; other site
553174000341	putative ATP binding site [chemical binding]; other site
553174000342	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
553174000343	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
553174000344	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
553174000345	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
553174000346	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
553174000347	active site
553174000348	catalytic residues [active]
553174000349	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
553174000350	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
553174000351	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174000352	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
553174000353	homotrimer interaction site [polypeptide binding]; other site
553174000354	zinc binding site [ion binding]; other site
553174000355	CDP-binding sites; other site
553174000356	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
553174000357	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
553174000358	active site
553174000359	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174000360	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
553174000361	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
553174000362	elongation factor Ts; Provisional; Region: tsf; PRK09377
553174000363	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
553174000364	Elongation factor TS; Region: EF_TS; pfam00889
553174000365	Elongation factor TS; Region: EF_TS; pfam00889
553174000366	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
553174000367	rRNA interaction site [nucleotide binding]; other site
553174000368	S8 interaction site; other site
553174000369	putative laminin-1 binding site; other site
553174000370	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
553174000371	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
553174000372	23S rRNA interface [nucleotide binding]; other site
553174000373	L3 interface [polypeptide binding]; other site
553174000374	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
553174000375	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
553174000376	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
553174000377	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
553174000378	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
553174000379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
553174000380	dimer interface [polypeptide binding]; other site
553174000381	phosphorylation site [posttranslational modification]
553174000382	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
553174000383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174000384	ATP binding site [chemical binding]; other site
553174000385	Mg2+ binding site [ion binding]; other site
553174000386	G-X-G motif; other site
553174000387	Response regulator receiver domain; Region: Response_reg; pfam00072
553174000388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
553174000389	active site
553174000390	phosphorylation site [posttranslational modification]
553174000391	intermolecular recognition site; other site
553174000392	dimerization interface [polypeptide binding]; other site
553174000393	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
553174000394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174000395	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000396	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000397	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174000398	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174000399	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174000400	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174000401	SusD family; Region: SusD; pfam07980
553174000402	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
553174000403	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
553174000404	substrate binding [chemical binding]; other site
553174000405	active site
553174000406	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
553174000407	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
553174000408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174000409	putative substrate translocation pore; other site
553174000410	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
553174000411	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
553174000412	putative substrate binding site [chemical binding]; other site
553174000413	putative ATP binding site [chemical binding]; other site
553174000414	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174000415	non-specific DNA binding site [nucleotide binding]; other site
553174000416	salt bridge; other site
553174000417	sequence-specific DNA binding site [nucleotide binding]; other site
553174000418	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
553174000419	Sulfatase; Region: Sulfatase; pfam00884
553174000420	Sulfatase; Region: Sulfatase; cl17466
553174000421	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
553174000422	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
553174000423	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
553174000424	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
553174000425	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
553174000426	nudix motif; other site
553174000427	DNA topoisomerase I; Provisional; Region: PRK08780
553174000428	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
553174000429	active site
553174000430	interdomain interaction site; other site
553174000431	putative metal-binding site [ion binding]; other site
553174000432	nucleotide binding site [chemical binding]; other site
553174000433	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
553174000434	domain I; other site
553174000435	DNA binding groove [nucleotide binding]
553174000436	phosphate binding site [ion binding]; other site
553174000437	domain II; other site
553174000438	domain III; other site
553174000439	nucleotide binding site [chemical binding]; other site
553174000440	catalytic site [active]
553174000441	domain IV; other site
553174000442	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
553174000443	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
553174000444	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
553174000445	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
553174000446	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
553174000447	ADP binding site [chemical binding]; other site
553174000448	magnesium binding site [ion binding]; other site
553174000449	putative shikimate binding site; other site
553174000450	arginine decarboxylase; Provisional; Region: PRK05354
553174000451	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
553174000452	dimer interface [polypeptide binding]; other site
553174000453	active site
553174000454	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174000455	catalytic residues [active]
553174000456	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
553174000457	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
553174000458	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
553174000459	generic binding surface II; other site
553174000460	ssDNA binding site; other site
553174000461	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174000462	ATP binding site [chemical binding]; other site
553174000463	putative Mg++ binding site [ion binding]; other site
553174000464	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174000465	nucleotide binding region [chemical binding]; other site
553174000466	ATP-binding site [chemical binding]; other site
553174000467	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
553174000468	Peptidase family M23; Region: Peptidase_M23; pfam01551
553174000469	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
553174000470	anaerobic sulfatase-maturase; Provisional; Region: PRK13745
553174000471	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174000472	FeS/SAM binding site; other site
553174000473	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
553174000474	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174000475	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
553174000476	metal-binding site
553174000477	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174000478	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
553174000479	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
553174000480	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174000481	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174000482	DNA binding residues [nucleotide binding]
553174000483	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
553174000484	substrate binding site; other site
553174000485	dimer interface; other site
553174000486	DJ-1 family protein; Region: not_thiJ; TIGR01383
553174000487	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
553174000488	conserved cys residue [active]
553174000489	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
553174000490	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
553174000491	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
553174000492	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
553174000493	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
553174000494	Walker A/P-loop; other site
553174000495	ATP binding site [chemical binding]; other site
553174000496	Q-loop/lid; other site
553174000497	ABC transporter signature motif; other site
553174000498	Walker B; other site
553174000499	D-loop; other site
553174000500	H-loop/switch region; other site
553174000501	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
553174000502	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174000503	catalytic residues [active]
553174000504	Gram-negative bacterial tonB protein; Region: TonB; cl10048
553174000505	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
553174000506	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
553174000507	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
553174000508	Ca binding site [ion binding]; other site
553174000509	active site
553174000510	homodimer interface [polypeptide binding]; other site
553174000511	catalytic site [active]
553174000512	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
553174000513	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
553174000514	pullulanase, type I; Region: pulA_typeI; TIGR02104
553174000515	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
553174000516	Ca binding site [ion binding]; other site
553174000517	active site
553174000518	catalytic site [active]
553174000519	4-alpha-glucanotransferase; Region: PLN02950
553174000520	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
553174000521	starch-binding site 2 [chemical binding]; other site
553174000522	starch-binding site 1 [chemical binding]; other site
553174000523	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
553174000524	starch-binding site 2 [chemical binding]; other site
553174000525	starch-binding site 1 [chemical binding]; other site
553174000526	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
553174000527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174000528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
553174000529	putative substrate translocation pore; other site
553174000530	Transcriptional regulators [Transcription]; Region: PurR; COG1609
553174000531	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
553174000532	DNA binding site [nucleotide binding]
553174000533	domain linker motif; other site
553174000534	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
553174000535	dimerization interface [polypeptide binding]; other site
553174000536	ligand binding site [chemical binding]; other site
553174000537	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000538	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000539	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174000540	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174000541	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174000542	SusD family; Region: SusD; pfam07980
553174000543	SusE outer membrane protein; Region: SusE; pfam14292
553174000544	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
553174000545	starch binding site [chemical binding]; other site
553174000546	Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967
553174000547	starch binding site [chemical binding]; other site
553174000548	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956
553174000549	starch binding site [chemical binding]; other site
553174000550	alpha-amylase; Region: PLN02361
553174000551	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
553174000552	active site
553174000553	Ca binding site [ion binding]; other site
553174000554	catalytic site [active]
553174000555	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
553174000556	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
553174000557	non-heme iron binding site [ion binding]; other site
553174000558	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174000559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174000560	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
553174000561	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
553174000562	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
553174000563	protein binding site [polypeptide binding]; other site
553174000564	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
553174000565	Catalytic dyad [active]
553174000566	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
553174000567	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
553174000568	hypothetical protein; Validated; Region: PRK02001
553174000569	Sm1 motif; other site
553174000570	RNA binding site [nucleotide binding]; other site
553174000571	transcription termination factor NusA; Region: NusA; TIGR01953
553174000572	NusA N-terminal domain; Region: NusA_N; pfam08529
553174000573	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
553174000574	RNA binding site [nucleotide binding]; other site
553174000575	homodimer interface [polypeptide binding]; other site
553174000576	NusA-like KH domain; Region: KH_5; pfam13184
553174000577	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
553174000578	G-X-X-G motif; other site
553174000579	translation initiation factor IF-2; Region: IF-2; TIGR00487
553174000580	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
553174000581	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
553174000582	G1 box; other site
553174000583	putative GEF interaction site [polypeptide binding]; other site
553174000584	GTP/Mg2+ binding site [chemical binding]; other site
553174000585	Switch I region; other site
553174000586	G2 box; other site
553174000587	G3 box; other site
553174000588	Switch II region; other site
553174000589	G4 box; other site
553174000590	G5 box; other site
553174000591	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
553174000592	Translation-initiation factor 2; Region: IF-2; pfam11987
553174000593	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
553174000594	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
553174000595	putative ABC transporter; Region: ycf24; CHL00085
553174000596	FeS assembly ATPase SufC; Region: sufC; TIGR01978
553174000597	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
553174000598	Walker A/P-loop; other site
553174000599	ATP binding site [chemical binding]; other site
553174000600	Q-loop/lid; other site
553174000601	ABC transporter signature motif; other site
553174000602	Walker B; other site
553174000603	D-loop; other site
553174000604	H-loop/switch region; other site
553174000605	FeS assembly protein SufD; Region: sufD; TIGR01981
553174000606	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
553174000607	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
553174000608	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
553174000609	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
553174000610	catalytic residue [active]
553174000611	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
553174000612	RNA/DNA hybrid binding site [nucleotide binding]; other site
553174000613	active site
553174000614	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000615	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000616	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174000617	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174000618	SusD family; Region: SusD; pfam07980
553174000619	Predicted transcriptional regulator [Transcription]; Region: COG2378
553174000620	WYL domain; Region: WYL; pfam13280
553174000621	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
553174000622	active site
553174000623	catalytic triad [active]
553174000624	oxyanion hole [active]
553174000625	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
553174000626	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
553174000627	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174000628	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174000629	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
553174000630	phosphoglyceromutase; Provisional; Region: PRK05434
553174000631	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
553174000632	ligand binding site [chemical binding]; other site
553174000633	active site
553174000634	UGI interface [polypeptide binding]; other site
553174000635	catalytic site [active]
553174000636	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
553174000637	ligand binding site [chemical binding]; other site
553174000638	active site
553174000639	UGI interface [polypeptide binding]; other site
553174000640	catalytic site [active]
553174000641	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
553174000642	Helix-turn-helix domain; Region: HTH_18; pfam12833
553174000643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174000644	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
553174000645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174000646	ATP binding site [chemical binding]; other site
553174000647	Mg2+ binding site [ion binding]; other site
553174000648	G-X-G motif; other site
553174000649	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
553174000650	anchoring element; other site
553174000651	dimer interface [polypeptide binding]; other site
553174000652	ATP binding site [chemical binding]; other site
553174000653	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
553174000654	active site
553174000655	metal binding site [ion binding]; metal-binding site
553174000656	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
553174000657	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
553174000658	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
553174000659	N-terminal plug; other site
553174000660	ligand-binding site [chemical binding]; other site
553174000661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174000662	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
553174000663	putative substrate translocation pore; other site
553174000664	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
553174000665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174000666	FeS/SAM binding site; other site
553174000667	HemN C-terminal domain; Region: HemN_C; pfam06969
553174000668	protoporphyrinogen oxidase; Region: PLN02576
553174000669	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
553174000670	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
553174000671	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
553174000672	Recombination protein O N terminal; Region: RecO_N; pfam11967
553174000673	Recombination protein O C terminal; Region: RecO_C; pfam02565
553174000674	Predicted membrane protein [Function unknown]; Region: COG2855
553174000675	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174000676	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174000677	cell division protein FtsZ; Validated; Region: PRK09330
553174000678	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
553174000679	nucleotide binding site [chemical binding]; other site
553174000680	SulA interaction site; other site
553174000681	Cell division protein FtsA; Region: FtsA; smart00842
553174000682	Cell division protein FtsA; Region: FtsA; pfam14450
553174000683	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
553174000684	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
553174000685	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
553174000686	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
553174000687	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
553174000688	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
553174000689	homodimer interface [polypeptide binding]; other site
553174000690	active site
553174000691	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
553174000692	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
553174000693	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
553174000694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
553174000695	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
553174000696	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
553174000697	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
553174000698	Mg++ binding site [ion binding]; other site
553174000699	putative catalytic motif [active]
553174000700	putative substrate binding site [chemical binding]; other site
553174000701	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
553174000702	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
553174000703	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
553174000704	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
553174000705	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
553174000706	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
553174000707	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
553174000708	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
553174000709	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
553174000710	MraW methylase family; Region: Methyltransf_5; cl17771
553174000711	cell division protein MraZ; Reviewed; Region: PRK00326
553174000712	MraZ protein; Region: MraZ; pfam02381
553174000713	MraZ protein; Region: MraZ; pfam02381
553174000714	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
553174000715	putative acyl-acceptor binding pocket; other site
553174000716	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
553174000717	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
553174000718	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
553174000719	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
553174000720	Helix-turn-helix domain; Region: HTH_18; pfam12833
553174000721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174000722	AAA domain; Region: AAA_22; pfam13401
553174000723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174000724	Walker A motif; other site
553174000725	ATP binding site [chemical binding]; other site
553174000726	Walker B motif; other site
553174000727	Family description; Region: UvrD_C_2; pfam13538
553174000728	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
553174000729	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
553174000730	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
553174000731	catalytic triad [active]
553174000732	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
553174000733	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
553174000734	active site
553174000735	Zn binding site [ion binding]; other site
553174000736	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
553174000737	AAA domain; Region: AAA_14; pfam13173
553174000738	Surface protein; Region: DUF3664; pfam12406
553174000739	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
553174000740	hypothetical protein; Provisional; Region: PRK10649
553174000741	Sulfatase; Region: Sulfatase; cl17466
553174000742	Acyltransferase family; Region: Acyl_transf_3; pfam01757
553174000743	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
553174000744	Acyltransferase family; Region: Acyl_transf_3; pfam01757
553174000745	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
553174000746	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
553174000747	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174000748	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174000749	active site
553174000750	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
553174000751	LicD family; Region: LicD; cl01378
553174000752	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
553174000753	substrate binding site; other site
553174000754	dimer interface; other site
553174000755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174000756	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
553174000757	NAD(P) binding site [chemical binding]; other site
553174000758	active site
553174000759	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
553174000760	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
553174000761	active site
553174000762	(T/H)XGH motif; other site
553174000763	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
553174000764	putative active site [active]
553174000765	Guanylate kinase; Region: Guanylate_kin; pfam00625
553174000766	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
553174000767	catalytic site [active]
553174000768	G-X2-G-X-G-K; other site
553174000769	hypothetical protein; Provisional; Region: PRK11820
553174000770	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
553174000771	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
553174000772	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
553174000773	Glycoprotease family; Region: Peptidase_M22; pfam00814
553174000774	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
553174000775	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
553174000776	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
553174000777	hinge; other site
553174000778	active site
553174000779	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
553174000780	RimM N-terminal domain; Region: RimM; pfam01782
553174000781	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
553174000782	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
553174000783	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
553174000784	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
553174000785	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
553174000786	RIP metalloprotease RseP; Region: TIGR00054
553174000787	active site
553174000788	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
553174000789	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
553174000790	putative substrate binding region [chemical binding]; other site
553174000791	Chromate transporter; Region: Chromate_transp; pfam02417
553174000792	Chromate transporter; Region: Chromate_transp; pfam02417
553174000793	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
553174000794	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
553174000795	dimerization interface [polypeptide binding]; other site
553174000796	ATP binding site [chemical binding]; other site
553174000797	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
553174000798	dimerization interface [polypeptide binding]; other site
553174000799	ATP binding site [chemical binding]; other site
553174000800	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
553174000801	putative active site [active]
553174000802	catalytic triad [active]
553174000803	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
553174000804	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174000805	ligand binding site [chemical binding]; other site
553174000806	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
553174000807	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
553174000808	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
553174000809	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
553174000810	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
553174000811	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
553174000812	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
553174000813	GldM N-terminal domain; Region: GldM_N; pfam12081
553174000814	GldM C-terminal domain; Region: GldM_C; pfam12080
553174000815	gliding motility associated protien GldN; Region: GldN; TIGR03523
553174000816	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174000817	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
553174000818	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174000819	ATP binding site [chemical binding]; other site
553174000820	putative Mg++ binding site [ion binding]; other site
553174000821	helicase superfamily c-terminal domain; Region: HELICc; smart00490
553174000822	ATP-binding site [chemical binding]; other site
553174000823	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174000824	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
553174000825	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
553174000826	Zn2+ binding site [ion binding]; other site
553174000827	Mg2+ binding site [ion binding]; other site
553174000828	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
553174000829	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
553174000830	HIGH motif; other site
553174000831	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
553174000832	active site
553174000833	KMSKS motif; other site
553174000834	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
553174000835	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
553174000836	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
553174000837	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
553174000838	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
553174000839	active site
553174000840	HIGH motif; other site
553174000841	dimer interface [polypeptide binding]; other site
553174000842	KMSKS motif; other site
553174000843	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000844	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000845	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174000846	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174000847	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174000848	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174000849	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
553174000850	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
553174000851	NAD(P) binding site [chemical binding]; other site
553174000852	LDH/MDH dimer interface [polypeptide binding]; other site
553174000853	substrate binding site [chemical binding]; other site
553174000854	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
553174000855	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
553174000856	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
553174000857	active site
553174000858	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
553174000859	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174000860	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
553174000861	active site
553174000862	DNA binding site [nucleotide binding]
553174000863	Int/Topo IB signature motif; other site
553174000864	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
553174000865	30S subunit binding site; other site
553174000866	elongation factor Tu; Reviewed; Region: PRK12735
553174000867	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
553174000868	G1 box; other site
553174000869	GEF interaction site [polypeptide binding]; other site
553174000870	GTP/Mg2+ binding site [chemical binding]; other site
553174000871	Switch I region; other site
553174000872	G2 box; other site
553174000873	G3 box; other site
553174000874	Switch II region; other site
553174000875	G4 box; other site
553174000876	G5 box; other site
553174000877	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
553174000878	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
553174000879	Antibiotic Binding Site [chemical binding]; other site
553174000880	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
553174000881	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
553174000882	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
553174000883	putative homodimer interface [polypeptide binding]; other site
553174000884	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
553174000885	heterodimer interface [polypeptide binding]; other site
553174000886	homodimer interface [polypeptide binding]; other site
553174000887	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
553174000888	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
553174000889	23S rRNA interface [nucleotide binding]; other site
553174000890	L7/L12 interface [polypeptide binding]; other site
553174000891	putative thiostrepton binding site; other site
553174000892	L25 interface [polypeptide binding]; other site
553174000893	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
553174000894	mRNA/rRNA interface [nucleotide binding]; other site
553174000895	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
553174000896	23S rRNA interface [nucleotide binding]; other site
553174000897	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
553174000898	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
553174000899	core dimer interface [polypeptide binding]; other site
553174000900	peripheral dimer interface [polypeptide binding]; other site
553174000901	L10 interface [polypeptide binding]; other site
553174000902	L11 interface [polypeptide binding]; other site
553174000903	putative EF-Tu interaction site [polypeptide binding]; other site
553174000904	putative EF-G interaction site [polypeptide binding]; other site
553174000905	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
553174000906	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
553174000907	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
553174000908	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
553174000909	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
553174000910	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
553174000911	RPB3 interaction site [polypeptide binding]; other site
553174000912	RPB1 interaction site [polypeptide binding]; other site
553174000913	RPB11 interaction site [polypeptide binding]; other site
553174000914	RPB10 interaction site [polypeptide binding]; other site
553174000915	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
553174000916	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
553174000917	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
553174000918	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
553174000919	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
553174000920	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
553174000921	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
553174000922	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
553174000923	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
553174000924	DNA binding site [nucleotide binding]
553174000925	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
553174000926	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
553174000927	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174000928	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
553174000929	Sulfatase; Region: Sulfatase; pfam00884
553174000930	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174000931	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174000932	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
553174000933	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174000934	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
553174000935	S17 interaction site [polypeptide binding]; other site
553174000936	S8 interaction site; other site
553174000937	16S rRNA interaction site [nucleotide binding]; other site
553174000938	streptomycin interaction site [chemical binding]; other site
553174000939	23S rRNA interaction site [nucleotide binding]; other site
553174000940	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
553174000941	30S ribosomal protein S7; Validated; Region: PRK05302
553174000942	elongation factor G; Reviewed; Region: PRK12739
553174000943	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
553174000944	G1 box; other site
553174000945	putative GEF interaction site [polypeptide binding]; other site
553174000946	GTP/Mg2+ binding site [chemical binding]; other site
553174000947	Switch I region; other site
553174000948	G2 box; other site
553174000949	G3 box; other site
553174000950	Switch II region; other site
553174000951	G4 box; other site
553174000952	G5 box; other site
553174000953	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
553174000954	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
553174000955	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
553174000956	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
553174000957	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
553174000958	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
553174000959	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
553174000960	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
553174000961	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
553174000962	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
553174000963	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
553174000964	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
553174000965	putative translocon binding site; other site
553174000966	protein-rRNA interface [nucleotide binding]; other site
553174000967	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
553174000968	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
553174000969	G-X-X-G motif; other site
553174000970	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
553174000971	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
553174000972	23S rRNA interface [nucleotide binding]; other site
553174000973	5S rRNA interface [nucleotide binding]; other site
553174000974	putative antibiotic binding site [chemical binding]; other site
553174000975	L25 interface [polypeptide binding]; other site
553174000976	L27 interface [polypeptide binding]; other site
553174000977	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
553174000978	23S rRNA interface [nucleotide binding]; other site
553174000979	putative translocon interaction site; other site
553174000980	signal recognition particle (SRP54) interaction site; other site
553174000981	L23 interface [polypeptide binding]; other site
553174000982	trigger factor interaction site; other site
553174000983	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
553174000984	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
553174000985	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
553174000986	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
553174000987	RNA binding site [nucleotide binding]; other site
553174000988	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
553174000989	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
553174000990	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
553174000991	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
553174000992	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
553174000993	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
553174000994	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
553174000995	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
553174000996	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
553174000997	5S rRNA interface [nucleotide binding]; other site
553174000998	23S rRNA interface [nucleotide binding]; other site
553174000999	L5 interface [polypeptide binding]; other site
553174001000	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
553174001001	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
553174001002	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
553174001003	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
553174001004	23S rRNA binding site [nucleotide binding]; other site
553174001005	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
553174001006	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
553174001007	SecY translocase; Region: SecY; pfam00344
553174001008	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
553174001009	active site
553174001010	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
553174001011	rRNA binding site [nucleotide binding]; other site
553174001012	predicted 30S ribosome binding site; other site
553174001013	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
553174001014	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
553174001015	30S ribosomal protein S13; Region: bact_S13; TIGR03631
553174001016	30S ribosomal protein S11; Validated; Region: PRK05309
553174001017	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
553174001018	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
553174001019	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
553174001020	RNA binding surface [nucleotide binding]; other site
553174001021	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
553174001022	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
553174001023	alphaNTD - beta interaction site [polypeptide binding]; other site
553174001024	alphaNTD homodimer interface [polypeptide binding]; other site
553174001025	alphaNTD - beta' interaction site [polypeptide binding]; other site
553174001026	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
553174001027	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
553174001028	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174001029	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174001030	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174001031	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174001032	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001033	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
553174001034	Leucine rich repeat; Region: LRR_8; pfam13855
553174001035	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
553174001036	Substrate binding site [chemical binding]; other site
553174001037	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
553174001038	stage V sporulation protein K; Region: spore_V_K; TIGR02881
553174001039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001040	Walker A motif; other site
553174001041	ATP binding site [chemical binding]; other site
553174001042	Walker B motif; other site
553174001043	arginine finger; other site
553174001044	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
553174001045	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
553174001046	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
553174001047	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
553174001048	glutamate dehydrogenase; Provisional; Region: PRK14030
553174001049	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
553174001050	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
553174001051	NAD(P) binding site [chemical binding]; other site
553174001052	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
553174001053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174001054	non-specific DNA binding site [nucleotide binding]; other site
553174001055	salt bridge; other site
553174001056	sequence-specific DNA binding site [nucleotide binding]; other site
553174001057	HipA N-terminal domain; Region: Couple_hipA; cl11853
553174001058	HipA-like N-terminal domain; Region: HipA_N; pfam07805
553174001059	HipA-like C-terminal domain; Region: HipA_C; pfam07804
553174001060	acyl-CoA synthetase; Provisional; Region: PRK13383
553174001061	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174001062	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
553174001063	acyl-activating enzyme (AAE) consensus motif; other site
553174001064	AMP binding site [chemical binding]; other site
553174001065	active site
553174001066	CoA binding site [chemical binding]; other site
553174001067	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
553174001068	classical (c) SDRs; Region: SDR_c; cd05233
553174001069	NAD(P) binding site [chemical binding]; other site
553174001070	active site
553174001071	RDD family; Region: RDD; pfam06271
553174001072	Integral membrane protein DUF95; Region: DUF95; pfam01944
553174001073	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
553174001074	MoxR-like ATPases [General function prediction only]; Region: COG0714
553174001075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001076	Walker A motif; other site
553174001077	ATP binding site [chemical binding]; other site
553174001078	Walker B motif; other site
553174001079	arginine finger; other site
553174001080	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
553174001081	Protein of unknown function DUF58; Region: DUF58; pfam01882
553174001082	Lipocalin-like domain; Region: Lipocalin_6; pfam13944
553174001083	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
553174001084	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
553174001085	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
553174001086	N-terminal plug; other site
553174001087	ligand-binding site [chemical binding]; other site
553174001088	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
553174001089	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174001090	catalytic residues [active]
553174001091	Outer membrane protein Omp28; Region: Omp28; pfam11551
553174001092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174001093	Walker A/P-loop; other site
553174001094	ATP binding site [chemical binding]; other site
553174001095	Q-loop/lid; other site
553174001096	ABC transporter signature motif; other site
553174001097	Walker B; other site
553174001098	D-loop; other site
553174001099	H-loop/switch region; other site
553174001100	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
553174001101	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174001102	active site
553174001103	motif I; other site
553174001104	motif II; other site
553174001105	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
553174001106	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
553174001107	amphipathic channel; other site
553174001108	Asn-Pro-Ala signature motifs; other site
553174001109	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
553174001110	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
553174001111	intersubunit interface [polypeptide binding]; other site
553174001112	active site
553174001113	zinc binding site [ion binding]; other site
553174001114	Na+ binding site [ion binding]; other site
553174001115	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
553174001116	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
553174001117	putative substrate binding site [chemical binding]; other site
553174001118	putative ATP binding site [chemical binding]; other site
553174001119	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174001120	active site
553174001121	adenylate kinase; Reviewed; Region: adk; PRK00279
553174001122	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
553174001123	AMP-binding site [chemical binding]; other site
553174001124	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
553174001125	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
553174001126	four helix bundle protein; Region: TIGR02436
553174001127	GTPase CgtA; Reviewed; Region: obgE; PRK12299
553174001128	GTP1/OBG; Region: GTP1_OBG; pfam01018
553174001129	Obg GTPase; Region: Obg; cd01898
553174001130	G1 box; other site
553174001131	GTP/Mg2+ binding site [chemical binding]; other site
553174001132	Switch I region; other site
553174001133	G2 box; other site
553174001134	G3 box; other site
553174001135	Switch II region; other site
553174001136	G4 box; other site
553174001137	G5 box; other site
553174001138	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
553174001139	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
553174001140	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
553174001141	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
553174001142	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
553174001143	homotrimer interaction site [polypeptide binding]; other site
553174001144	putative active site [active]
553174001145	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
553174001146	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
553174001147	active site
553174001148	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
553174001149	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174001150	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001151	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
553174001152	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
553174001153	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
553174001154	active site
553174001155	metal binding site [ion binding]; metal-binding site
553174001156	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174001157	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174001158	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174001159	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
553174001160	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
553174001161	hydrophobic ligand binding site; other site
553174001162	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
553174001163	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
553174001164	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
553174001165	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
553174001166	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
553174001167	dimerization interface [polypeptide binding]; other site
553174001168	active site
553174001169	aspartate aminotransferase; Provisional; Region: PRK05764
553174001170	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
553174001171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174001172	homodimer interface [polypeptide binding]; other site
553174001173	catalytic residue [active]
553174001174	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
553174001175	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
553174001176	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
553174001177	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
553174001178	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
553174001179	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174001180	PBP superfamily domain; Region: PBP_like_2; pfam12849
553174001181	Tetratricopeptide repeat; Region: TPR_12; pfam13424
553174001182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174001183	TPR motif; other site
553174001184	binding surface
553174001185	muropeptide transporter; Reviewed; Region: ampG; PRK11902
553174001186	muropeptide transporter; Validated; Region: ampG; cl17669
553174001187	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
553174001188	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
553174001189	minor groove reading motif; other site
553174001190	helix-hairpin-helix signature motif; other site
553174001191	substrate binding pocket [chemical binding]; other site
553174001192	active site
553174001193	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
553174001194	DNA binding and oxoG recognition site [nucleotide binding]
553174001195	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
553174001196	purine monophosphate binding site [chemical binding]; other site
553174001197	dimer interface [polypeptide binding]; other site
553174001198	putative catalytic residues [active]
553174001199	rod shape-determining protein MreB; Provisional; Region: PRK13927
553174001200	MreB and similar proteins; Region: MreB_like; cd10225
553174001201	nucleotide binding site [chemical binding]; other site
553174001202	Mg binding site [ion binding]; other site
553174001203	putative protofilament interaction site [polypeptide binding]; other site
553174001204	RodZ interaction site [polypeptide binding]; other site
553174001205	rod shape-determining protein MreC; Provisional; Region: PRK13922
553174001206	rod shape-determining protein MreC; Region: MreC; pfam04085
553174001207	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
553174001208	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
553174001209	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
553174001210	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
553174001211	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
553174001212	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
553174001213	GldH lipoprotein; Region: GldH_lipo; pfam14109
553174001214	PSP1 C-terminal conserved region; Region: PSP1; cl00770
553174001215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
553174001216	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
553174001217	Walker A motif; other site
553174001218	ATP binding site [chemical binding]; other site
553174001219	DNA polymerase III subunit delta'; Validated; Region: PRK08485
553174001220	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
553174001221	FAD binding site [chemical binding]; other site
553174001222	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
553174001223	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
553174001224	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
553174001225	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
553174001226	ligand binding site [chemical binding]; other site
553174001227	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
553174001228	Domain of unknown function DUF20; Region: UPF0118; pfam01594
553174001229	thymidine kinase; Provisional; Region: PRK04296
553174001230	Predicted methyltransferases [General function prediction only]; Region: COG0313
553174001231	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
553174001232	putative SAM binding site [chemical binding]; other site
553174001233	putative homodimer interface [polypeptide binding]; other site
553174001234	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
553174001235	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
553174001236	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174001237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174001238	DNA binding residues [nucleotide binding]
553174001239	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
553174001240	nucleoside/Zn binding site; other site
553174001241	dimer interface [polypeptide binding]; other site
553174001242	catalytic motif [active]
553174001243	hypothetical protein; Reviewed; Region: PRK12497
553174001244	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
553174001245	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
553174001246	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
553174001247	putative nucleotide binding site [chemical binding]; other site
553174001248	uridine monophosphate binding site [chemical binding]; other site
553174001249	homohexameric interface [polypeptide binding]; other site
553174001250	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
553174001251	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
553174001252	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
553174001253	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174001254	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174001255	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174001256	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001257	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174001258	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174001259	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
553174001260	active site
553174001261	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
553174001262	active site
553174001263	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174001264	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001265	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174001266	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
553174001267	catalytic residues [active]
553174001268	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
553174001269	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
553174001270	active site
553174001271	PHP Thumb interface [polypeptide binding]; other site
553174001272	metal binding site [ion binding]; metal-binding site
553174001273	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
553174001274	generic binding surface II; other site
553174001275	generic binding surface I; other site
553174001276	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
553174001277	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
553174001278	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
553174001279	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
553174001280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
553174001281	Response regulator receiver domain; Region: Response_reg; pfam00072
553174001282	active site
553174001283	phosphorylation site [posttranslational modification]
553174001284	intermolecular recognition site; other site
553174001285	dimerization interface [polypeptide binding]; other site
553174001286	PglZ domain; Region: PglZ; pfam08665
553174001287	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
553174001288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174001289	TPR motif; other site
553174001290	binding surface
553174001291	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
553174001292	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
553174001293	hinge; other site
553174001294	active site
553174001295	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174001296	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
553174001297	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
553174001298	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
553174001299	active site
553174001300	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
553174001301	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
553174001302	N-terminal plug; other site
553174001303	ligand-binding site [chemical binding]; other site
553174001304	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174001305	active site
553174001306	xanthine permease; Region: pbuX; TIGR03173
553174001307	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
553174001308	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174001309	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
553174001310	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
553174001311	active site
553174001312	catalytic triad [active]
553174001313	oxyanion hole [active]
553174001314	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
553174001315	active site
553174001316	putative catalytic site [active]
553174001317	DNA binding site [nucleotide binding]
553174001318	putative phosphate binding site [ion binding]; other site
553174001319	metal binding site A [ion binding]; metal-binding site
553174001320	AP binding site [nucleotide binding]; other site
553174001321	metal binding site B [ion binding]; metal-binding site
553174001322	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
553174001323	homodecamer interface [polypeptide binding]; other site
553174001324	GTP cyclohydrolase I; Provisional; Region: PLN03044
553174001325	active site
553174001326	putative catalytic site residues [active]
553174001327	zinc binding site [ion binding]; other site
553174001328	GTP-CH-I/GFRP interaction surface; other site
553174001329	triosephosphate isomerase; Provisional; Region: PRK14565
553174001330	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
553174001331	substrate binding site [chemical binding]; other site
553174001332	dimer interface [polypeptide binding]; other site
553174001333	catalytic triad [active]
553174001334	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
553174001335	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
553174001336	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
553174001337	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
553174001338	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
553174001339	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
553174001340	active site
553174001341	NTP binding site [chemical binding]; other site
553174001342	metal binding triad [ion binding]; metal-binding site
553174001343	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
553174001344	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
553174001345	Zn2+ binding site [ion binding]; other site
553174001346	Mg2+ binding site [ion binding]; other site
553174001347	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
553174001348	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
553174001349	HlyD family secretion protein; Region: HlyD_3; pfam13437
553174001350	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
553174001351	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
553174001352	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
553174001353	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
553174001354	putative trimer interface [polypeptide binding]; other site
553174001355	putative CoA binding site [chemical binding]; other site
553174001356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174001357	Radical SAM superfamily; Region: Radical_SAM; pfam04055
553174001358	FeS/SAM binding site; other site
553174001359	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
553174001360	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
553174001361	G1 box; other site
553174001362	putative GEF interaction site [polypeptide binding]; other site
553174001363	GTP/Mg2+ binding site [chemical binding]; other site
553174001364	Switch I region; other site
553174001365	G2 box; other site
553174001366	G3 box; other site
553174001367	Switch II region; other site
553174001368	G4 box; other site
553174001369	G5 box; other site
553174001370	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
553174001371	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
553174001372	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
553174001373	16S/18S rRNA binding site [nucleotide binding]; other site
553174001374	S13e-L30e interaction site [polypeptide binding]; other site
553174001375	25S rRNA binding site [nucleotide binding]; other site
553174001376	Peptidase C10 family; Region: Peptidase_C10; pfam01640
553174001377	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
553174001378	catalytic center binding site [active]
553174001379	ATP binding site [chemical binding]; other site
553174001380	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
553174001381	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
553174001382	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
553174001383	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
553174001384	RNA binding site [nucleotide binding]; other site
553174001385	active site
553174001386	Bacitracin resistance protein BacA; Region: BacA; pfam02673
553174001387	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
553174001388	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
553174001389	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
553174001390	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174001391	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
553174001392	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174001393	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174001394	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174001395	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001396	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174001397	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
553174001398	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174001399	Tetratricopeptide repeat; Region: TPR_12; pfam13424
553174001400	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174001401	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
553174001402	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174001403	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174001404	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174001405	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
553174001406	Cation efflux family; Region: Cation_efflux; pfam01545
553174001407	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174001408	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174001409	active site
553174001410	GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103
553174001411	Stage II sporulation protein; Region: SpoIID; pfam08486
553174001412	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
553174001413	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
553174001414	muropeptide transporter; Validated; Region: ampG; cl17669
553174001415	Peptidase family M48; Region: Peptidase_M48; pfam01435
553174001416	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
553174001417	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
553174001418	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
553174001419	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
553174001420	active site
553174001421	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
553174001422	homodimer interface [polypeptide binding]; other site
553174001423	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
553174001424	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174001425	Heavy-metal-associated domain; Region: HMA; pfam00403
553174001426	Helix-turn-helix domain; Region: HTH_18; pfam12833
553174001427	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174001428	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
553174001429	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
553174001430	metal-binding site [ion binding]
553174001431	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
553174001432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174001433	active site
553174001434	motif I; other site
553174001435	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
553174001436	motif II; other site
553174001437	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
553174001438	active site
553174001439	catalytic residues [active]
553174001440	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
553174001441	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
553174001442	Chorismate mutase type II; Region: CM_2; smart00830
553174001443	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
553174001444	putative catalytic site [active]
553174001445	putative metal binding site [ion binding]; other site
553174001446	putative phosphate binding site [ion binding]; other site
553174001447	Protein of unknown function, DUF481; Region: DUF481; cl01213
553174001448	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
553174001449	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
553174001450	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
553174001451	Predicted membrane protein [Function unknown]; Region: COG2323
553174001452	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
553174001453	catalytic triad [active]
553174001454	conserved cis-peptide bond; other site
553174001455	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
553174001456	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
553174001457	Tetramer interface [polypeptide binding]; other site
553174001458	active site
553174001459	FMN-binding site [chemical binding]; other site
553174001460	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
553174001461	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
553174001462	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
553174001463	active site
553174001464	catalytic residues [active]
553174001465	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
553174001466	catalytic residues [active]
553174001467	flavodoxin FldA; Validated; Region: PRK09267
553174001468	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
553174001469	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
553174001470	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
553174001471	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
553174001472	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
553174001473	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
553174001474	dimer interface [polypeptide binding]; other site
553174001475	FMN binding site [chemical binding]; other site
553174001476	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
553174001477	dimer interface [polypeptide binding]; other site
553174001478	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
553174001479	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
553174001480	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
553174001481	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
553174001482	MgtC family; Region: MgtC; pfam02308
553174001483	maltose O-acetyltransferase; Provisional; Region: PRK10092
553174001484	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
553174001485	active site
553174001486	substrate binding site [chemical binding]; other site
553174001487	trimer interface [polypeptide binding]; other site
553174001488	CoA binding site [chemical binding]; other site
553174001489	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174001490	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174001491	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174001492	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174001493	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174001494	SusD family; Region: SusD; pfam07980
553174001495	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
553174001496	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
553174001497	N-terminal plug; other site
553174001498	ligand-binding site [chemical binding]; other site
553174001499	Protein of unknown function (DUF805); Region: DUF805; pfam05656
553174001500	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
553174001501	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
553174001502	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
553174001503	nucleotide binding pocket [chemical binding]; other site
553174001504	K-X-D-G motif; other site
553174001505	catalytic site [active]
553174001506	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
553174001507	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
553174001508	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
553174001509	Dimer interface [polypeptide binding]; other site
553174001510	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
553174001511	active site
553174001512	8-oxo-dGMP binding site [chemical binding]; other site
553174001513	nudix motif; other site
553174001514	metal binding site [ion binding]; metal-binding site
553174001515	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
553174001516	NHAD transporter family protein; Provisional; Region: PLN00137
553174001517	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
553174001518	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174001519	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
553174001520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
553174001521	Coenzyme A binding pocket [chemical binding]; other site
553174001522	AAA domain; Region: AAA_30; pfam13604
553174001523	Family description; Region: UvrD_C_2; pfam13538
553174001524	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
553174001525	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
553174001526	active site
553174001527	substrate binding site [chemical binding]; other site
553174001528	Mg2+ binding site [ion binding]; other site
553174001529	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
553174001530	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
553174001531	Walker A/P-loop; other site
553174001532	ATP binding site [chemical binding]; other site
553174001533	Q-loop/lid; other site
553174001534	ABC transporter signature motif; other site
553174001535	Walker B; other site
553174001536	D-loop; other site
553174001537	H-loop/switch region; other site
553174001538	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
553174001539	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
553174001540	DNA-binding site [nucleotide binding]; DNA binding site
553174001541	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
553174001542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174001543	ATP binding site [chemical binding]; other site
553174001544	putative Mg++ binding site [ion binding]; other site
553174001545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174001546	nucleotide binding region [chemical binding]; other site
553174001547	ATP-binding site [chemical binding]; other site
553174001548	recombinase A; Provisional; Region: recA; PRK09354
553174001549	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
553174001550	hexamer interface [polypeptide binding]; other site
553174001551	Walker A motif; other site
553174001552	ATP binding site [chemical binding]; other site
553174001553	Walker B motif; other site
553174001554	TfoX N-terminal domain; Region: TfoX_N; cl17592
553174001555	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
553174001556	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
553174001557	NAD(P) binding pocket [chemical binding]; other site
553174001558	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
553174001559	malate dehydrogenase; Provisional; Region: PRK13529
553174001560	Malic enzyme, N-terminal domain; Region: malic; pfam00390
553174001561	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
553174001562	NAD(P) binding site [chemical binding]; other site
553174001563	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
553174001564	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
553174001565	dimer interface [polypeptide binding]; other site
553174001566	PYR/PP interface [polypeptide binding]; other site
553174001567	TPP binding site [chemical binding]; other site
553174001568	substrate binding site [chemical binding]; other site
553174001569	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
553174001570	Domain of unknown function; Region: EKR; smart00890
553174001571	4Fe-4S binding domain; Region: Fer4_6; pfam12837
553174001572	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174001573	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
553174001574	TPP-binding site [chemical binding]; other site
553174001575	dimer interface [polypeptide binding]; other site
553174001576	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
553174001577	AAA domain; Region: AAA_14; pfam13173
553174001578	Helix-turn-helix domain; Region: HTH_36; pfam13730
553174001579	ATP-grasp domain; Region: ATP-grasp_4; cl17255
553174001580	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
553174001581	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
553174001582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174001583	S-adenosylmethionine binding site [chemical binding]; other site
553174001584	pyruvate phosphate dikinase; Provisional; Region: PRK09279
553174001585	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
553174001586	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
553174001587	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
553174001588	Beta-lactamase; Region: Beta-lactamase; pfam00144
553174001589	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
553174001590	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
553174001591	Clp amino terminal domain; Region: Clp_N; pfam02861
553174001592	Clp amino terminal domain; Region: Clp_N; pfam02861
553174001593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001594	Walker A motif; other site
553174001595	ATP binding site [chemical binding]; other site
553174001596	Walker B motif; other site
553174001597	arginine finger; other site
553174001598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001599	Walker A motif; other site
553174001600	ATP binding site [chemical binding]; other site
553174001601	Walker B motif; other site
553174001602	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
553174001603	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
553174001604	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174001605	FeS/SAM binding site; other site
553174001606	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
553174001607	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
553174001608	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
553174001609	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
553174001610	Catalytic site [active]
553174001611	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
553174001612	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
553174001613	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174001614	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
553174001615	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174001616	DNA binding residues [nucleotide binding]
553174001617	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
553174001618	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
553174001619	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
553174001620	protein binding site [polypeptide binding]; other site
553174001621	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
553174001622	protein binding site [polypeptide binding]; other site
553174001623	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
553174001624	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
553174001625	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
553174001626	Penicillinase repressor; Region: Pencillinase_R; pfam03965
553174001627	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
553174001628	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
553174001629	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
553174001630	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
553174001631	putative NADH binding site [chemical binding]; other site
553174001632	putative active site [active]
553174001633	nudix motif; other site
553174001634	putative metal binding site [ion binding]; other site
553174001635	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
553174001636	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
553174001637	active site
553174001638	metal binding site [ion binding]; metal-binding site
553174001639	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
553174001640	glutamate dehydrogenase; Provisional; Region: PRK14031
553174001641	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
553174001642	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
553174001643	NAD(P) binding site [chemical binding]; other site
553174001644	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
553174001645	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
553174001646	ATP binding site [chemical binding]; other site
553174001647	Mg++ binding site [ion binding]; other site
553174001648	motif III; other site
553174001649	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174001650	nucleotide binding region [chemical binding]; other site
553174001651	ATP-binding site [chemical binding]; other site
553174001652	Predicted permeases [General function prediction only]; Region: COG0795
553174001653	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
553174001654	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
553174001655	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
553174001656	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
553174001657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001658	Walker A motif; other site
553174001659	ATP binding site [chemical binding]; other site
553174001660	Walker B motif; other site
553174001661	arginine finger; other site
553174001662	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
553174001663	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
553174001664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174001665	S-adenosylmethionine binding site [chemical binding]; other site
553174001666	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
553174001667	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
553174001668	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
553174001669	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
553174001670	substrate-cofactor binding pocket; other site
553174001671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174001672	catalytic residue [active]
553174001673	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
553174001674	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
553174001675	dimer interface [polypeptide binding]; other site
553174001676	ssDNA binding site [nucleotide binding]; other site
553174001677	tetramer (dimer of dimers) interface [polypeptide binding]; other site
553174001678	gliding motility-associated protein GldE; Region: GldE; TIGR03520
553174001679	Domain of unknown function DUF21; Region: DUF21; pfam01595
553174001680	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
553174001681	Transporter associated domain; Region: CorC_HlyC; pfam03471
553174001682	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
553174001683	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
553174001684	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
553174001685	phosphoserine phosphatase SerB; Region: serB; TIGR00338
553174001686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174001687	motif II; other site
553174001688	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
553174001689	Chain length determinant protein; Region: Wzz; pfam02706
553174001690	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
553174001691	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
553174001692	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
553174001693	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
553174001694	substrate binding site; other site
553174001695	tetramer interface; other site
553174001696	Cell division protein ZapA; Region: ZapA; pfam05164
553174001697	phosphodiesterase; Provisional; Region: PRK12704
553174001698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
553174001699	Zn2+ binding site [ion binding]; other site
553174001700	Mg2+ binding site [ion binding]; other site
553174001701	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174001702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174001703	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
553174001704	probable metal-binding protein; Region: matur_matur; TIGR03853
553174001705	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
553174001706	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
553174001707	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
553174001708	dimer interface [polypeptide binding]; other site
553174001709	active site
553174001710	glycine-pyridoxal phosphate binding site [chemical binding]; other site
553174001711	folate binding site [chemical binding]; other site
553174001712	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
553174001713	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
553174001714	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
553174001715	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
553174001716	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
553174001717	NodB motif; other site
553174001718	active site
553174001719	catalytic site [active]
553174001720	metal binding site [ion binding]; metal-binding site
553174001721	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
553174001722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
553174001723	TPR motif; other site
553174001724	binding surface
553174001725	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
553174001726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174001727	Walker A/P-loop; other site
553174001728	ATP binding site [chemical binding]; other site
553174001729	Q-loop/lid; other site
553174001730	ABC transporter signature motif; other site
553174001731	Walker B; other site
553174001732	D-loop; other site
553174001733	H-loop/switch region; other site
553174001734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
553174001735	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
553174001736	ATP cone domain; Region: ATP-cone; pfam03477
553174001737	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
553174001738	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
553174001739	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
553174001740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174001741	motif II; other site
553174001742	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
553174001743	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174001744	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
553174001745	Ligand binding site; other site
553174001746	Putative Catalytic site; other site
553174001747	DXD motif; other site
553174001748	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
553174001749	ApbE family; Region: ApbE; pfam02424
553174001750	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
553174001751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
553174001752	ligand binding site [chemical binding]; other site
553174001753	flexible hinge region; other site
553174001754	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
553174001755	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
553174001756	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
553174001757	active site
553174001758	Zn binding site [ion binding]; other site
553174001759	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
553174001760	catalytic motif [active]
553174001761	Zn binding site [ion binding]; other site
553174001762	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
553174001763	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
553174001764	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
553174001765	protein binding site [polypeptide binding]; other site
553174001766	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
553174001767	Catalytic dyad [active]
553174001768	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
553174001769	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
553174001770	Initiator Replication protein; Region: Rep_3; pfam01051
553174001771	Hemerythrin-like domain; Region: Hr-like; cd12108
553174001772	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
553174001773	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
553174001774	DNA binding residues [nucleotide binding]
553174001775	dimerization interface [polypeptide binding]; other site
553174001776	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
553174001777	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
553174001778	DNA binding residues [nucleotide binding]
553174001779	dimerization interface [polypeptide binding]; other site
553174001780	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
553174001781	PLD-like domain; Region: PLDc_2; pfam13091
553174001782	putative active site [active]
553174001783	catalytic site [active]
553174001784	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
553174001785	PLD-like domain; Region: PLDc_2; pfam13091
553174001786	putative active site [active]
553174001787	catalytic site [active]
553174001788	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
553174001789	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
553174001790	putative active site [active]
553174001791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
553174001792	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
553174001793	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174001794	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
553174001795	Mechanosensitive ion channel; Region: MS_channel; pfam00924
553174001796	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
553174001797	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
553174001798	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
553174001799	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
553174001800	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
553174001801	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
553174001802	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
553174001803	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
553174001804	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
553174001805	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
553174001806	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
553174001807	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
553174001808	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
553174001809	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
553174001810	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
553174001811	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
553174001812	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
553174001813	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
553174001814	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
553174001815	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
553174001816	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
553174001817	DNA polymerase III subunit beta; Validated; Region: PRK05643
553174001818	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
553174001819	putative DNA binding surface [nucleotide binding]; other site
553174001820	dimer interface [polypeptide binding]; other site
553174001821	beta-clamp/clamp loader binding surface; other site
553174001822	beta-clamp/translesion DNA polymerase binding surface; other site
553174001823	exodeoxyribonuclease X; Provisional; Region: PRK07983
553174001824	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
553174001825	active site
553174001826	catalytic site [active]
553174001827	substrate binding site [chemical binding]; other site
553174001828	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
553174001829	Flavoprotein; Region: Flavoprotein; pfam02441
553174001830	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
553174001831	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
553174001832	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
553174001833	Walker A/P-loop; other site
553174001834	ATP binding site [chemical binding]; other site
553174001835	Q-loop/lid; other site
553174001836	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
553174001837	ABC transporter signature motif; other site
553174001838	Walker B; other site
553174001839	D-loop; other site
553174001840	H-loop/switch region; other site
553174001841	TPR repeat; Region: TPR_11; pfam13414
553174001842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
553174001843	TPR motif; other site
553174001844	binding surface
553174001845	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
553174001846	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174001847	active site
553174001848	DNA binding site [nucleotide binding]
553174001849	Int/Topo IB signature motif; other site
553174001850	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
553174001851	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
553174001852	Nuclease-related domain; Region: NERD; pfam08378
553174001853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
553174001854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174001855	ATP binding site [chemical binding]; other site
553174001856	Mg2+ binding site [ion binding]; other site
553174001857	G-X-G motif; other site
553174001858	WYL domain; Region: WYL; pfam13280
553174001859	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
553174001860	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
553174001861	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
553174001862	AAA domain; Region: AAA_31; pfam13614
553174001863	P-loop; other site
553174001864	Magnesium ion binding site [ion binding]; other site
553174001865	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
553174001866	Homeodomain-like domain; Region: HTH_23; pfam13384
553174001867	O-Antigen ligase; Region: Wzy_C; cl04850
553174001868	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
553174001869	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
553174001870	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
553174001871	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
553174001872	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
553174001873	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
553174001874	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
553174001875	TraX protein; Region: TraX; pfam05857
553174001876	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
553174001877	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
553174001878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
553174001879	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
553174001880	WYL domain; Region: WYL; pfam13280
553174001881	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
553174001882	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
553174001883	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174001884	ATP binding site [chemical binding]; other site
553174001885	putative Mg++ binding site [ion binding]; other site
553174001886	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174001887	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174001888	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174001889	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
553174001890	Fic/DOC family; Region: Fic; pfam02661
553174001891	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174001892	non-specific DNA binding site [nucleotide binding]; other site
553174001893	salt bridge; other site
553174001894	sequence-specific DNA binding site [nucleotide binding]; other site
553174001895	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
553174001896	AAA domain; Region: AAA_30; pfam13604
553174001897	AAA domain; Region: AAA_11; pfam13086
553174001898	Family description; Region: UvrD_C_2; pfam13538
553174001899	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
553174001900	Peptidase family M23; Region: Peptidase_M23; pfam01551
553174001901	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
553174001902	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
553174001903	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
553174001904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174001905	active site
553174001906	MutS domain I; Region: MutS_I; pfam01624
553174001907	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
553174001908	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
553174001909	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
553174001910	Toprim-like; Region: Toprim_2; pfam13155
553174001911	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
553174001912	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
553174001913	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
553174001914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174001915	salt bridge; other site
553174001916	non-specific DNA binding site [nucleotide binding]; other site
553174001917	sequence-specific DNA binding site [nucleotide binding]; other site
553174001918	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
553174001919	active site
553174001920	catalytic triad [active]
553174001921	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
553174001922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174001923	Walker A motif; other site
553174001924	ATP binding site [chemical binding]; other site
553174001925	Walker B motif; other site
553174001926	arginine finger; other site
553174001927	DNA primase, catalytic core; Region: dnaG; TIGR01391
553174001928	CHC2 zinc finger; Region: zf-CHC2; pfam01807
553174001929	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
553174001930	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
553174001931	active site
553174001932	metal binding site [ion binding]; metal-binding site
553174001933	interdomain interaction site; other site
553174001934	AAA domain; Region: AAA_14; pfam13173
553174001935	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
553174001936	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
553174001937	Sulfatase; Region: Sulfatase; pfam00884
553174001938	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
553174001939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174001940	motif II; other site
553174001941	OsmC-like protein; Region: OsmC; pfam02566
553174001942	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
553174001943	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
553174001944	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
553174001945	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
553174001946	CoA binding domain; Region: CoA_binding; smart00881
553174001947	CoA-ligase; Region: Ligase_CoA; pfam00549
553174001948	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
553174001949	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
553174001950	CoA-ligase; Region: Ligase_CoA; pfam00549
553174001951	butyrate kinase; Provisional; Region: PRK03011
553174001952	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
553174001953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
553174001954	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
553174001955	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
553174001956	NAD(P) binding site [chemical binding]; other site
553174001957	homodimer interface [polypeptide binding]; other site
553174001958	substrate binding site [chemical binding]; other site
553174001959	active site
553174001960	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174001961	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
553174001962	cation binding site [ion binding]; other site
553174001963	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
553174001964	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
553174001965	active site
553174001966	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
553174001967	ResB-like family; Region: ResB; pfam05140
553174001968	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
553174001969	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
553174001970	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
553174001971	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
553174001972	metal binding site 2 [ion binding]; metal-binding site
553174001973	putative DNA binding helix; other site
553174001974	metal binding site 1 [ion binding]; metal-binding site
553174001975	dimer interface [polypeptide binding]; other site
553174001976	structural Zn2+ binding site [ion binding]; other site
553174001977	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
553174001978	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
553174001979	GDP-binding site [chemical binding]; other site
553174001980	ACT binding site; other site
553174001981	IMP binding site; other site
553174001982	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
553174001983	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
553174001984	dimer interface [polypeptide binding]; other site
553174001985	motif 1; other site
553174001986	active site
553174001987	motif 2; other site
553174001988	motif 3; other site
553174001989	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
553174001990	anticodon binding site; other site
553174001991	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
553174001992	putative catalytic site [active]
553174001993	putative metal binding site [ion binding]; other site
553174001994	putative phosphate binding site [ion binding]; other site
553174001995	enolase; Provisional; Region: eno; PRK00077
553174001996	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
553174001997	dimer interface [polypeptide binding]; other site
553174001998	metal binding site [ion binding]; metal-binding site
553174001999	substrate binding pocket [chemical binding]; other site
553174002000	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
553174002001	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
553174002002	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
553174002003	Cysteine-rich domain; Region: CCG; pfam02754
553174002004	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
553174002005	Cysteine-rich domain; Region: CCG; pfam02754
553174002006	DNA topoisomerase III; Provisional; Region: PRK07726
553174002007	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
553174002008	active site
553174002009	putative interdomain interaction site [polypeptide binding]; other site
553174002010	putative metal-binding site [ion binding]; other site
553174002011	putative nucleotide binding site [chemical binding]; other site
553174002012	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
553174002013	domain I; other site
553174002014	DNA binding groove [nucleotide binding]
553174002015	phosphate binding site [ion binding]; other site
553174002016	domain II; other site
553174002017	domain III; other site
553174002018	nucleotide binding site [chemical binding]; other site
553174002019	catalytic site [active]
553174002020	domain IV; other site
553174002021	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
553174002022	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
553174002023	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
553174002024	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
553174002025	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
553174002026	Outer membrane efflux protein; Region: OEP; pfam02321
553174002027	Outer membrane efflux protein; Region: OEP; pfam02321
553174002028	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
553174002029	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
553174002030	HlyD family secretion protein; Region: HlyD_3; pfam13437
553174002031	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
553174002032	ABC-2 type transporter; Region: ABC2_membrane; cl17235
553174002033	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
553174002034	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
553174002035	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
553174002036	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
553174002037	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
553174002038	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
553174002039	putative NAD(P) binding site [chemical binding]; other site
553174002040	homodimer interface [polypeptide binding]; other site
553174002041	homotetramer interface [polypeptide binding]; other site
553174002042	active site
553174002043	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
553174002044	EamA-like transporter family; Region: EamA; pfam00892
553174002045	EamA-like transporter family; Region: EamA; pfam00892
553174002046	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
553174002047	EamA-like transporter family; Region: EamA; pfam00892
553174002048	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
553174002049	dimer interface [polypeptide binding]; other site
553174002050	substrate binding site [chemical binding]; other site
553174002051	ATP binding site [chemical binding]; other site
553174002052	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
553174002053	active site
553174002054	thiamine phosphate binding site [chemical binding]; other site
553174002055	pyrophosphate binding site [ion binding]; other site
553174002056	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
553174002057	ThiC-associated domain; Region: ThiC-associated; pfam13667
553174002058	ThiC family; Region: ThiC; pfam01964
553174002059	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
553174002060	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
553174002061	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
553174002062	thiamine phosphate binding site [chemical binding]; other site
553174002063	active site
553174002064	pyrophosphate binding site [ion binding]; other site
553174002065	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
553174002066	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
553174002067	putative ligand binding site [chemical binding]; other site
553174002068	putative NAD binding site [chemical binding]; other site
553174002069	catalytic site [active]
553174002070	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174002071	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
553174002072	oligomer interface [polypeptide binding]; other site
553174002073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
553174002074	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
553174002075	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
553174002076	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
553174002077	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
553174002078	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
553174002079	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
553174002080	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174002081	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
553174002082	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
553174002083	dimer interface [polypeptide binding]; other site
553174002084	ADP-ribose binding site [chemical binding]; other site
553174002085	active site
553174002086	nudix motif; other site
553174002087	metal binding site [ion binding]; metal-binding site
553174002088	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
553174002089	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
553174002090	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
553174002091	catalytic residues [active]
553174002092	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
553174002093	putative DNA binding site [nucleotide binding]; other site
553174002094	putative Zn2+ binding site [ion binding]; other site
553174002095	Phosphotransferase enzyme family; Region: APH; pfam01636
553174002096	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
553174002097	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
553174002098	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
553174002099	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
553174002100	Zn2+ binding site [ion binding]; other site
553174002101	Mg2+ binding site [ion binding]; other site
553174002102	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
553174002103	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
553174002104	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
553174002105	trimer interface [polypeptide binding]; other site
553174002106	active site
553174002107	UDP-GlcNAc binding site [chemical binding]; other site
553174002108	lipid binding site [chemical binding]; lipid-binding site
553174002109	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
553174002110	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
553174002111	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
553174002112	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
553174002113	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
553174002114	active site
553174002115	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
553174002116	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
553174002117	Transglycosylase; Region: Transgly; pfam00912
553174002118	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
553174002119	PIF1-like helicase; Region: PIF1; pfam05970
553174002120	AAA domain; Region: AAA_30; pfam13604
553174002121	Family description; Region: UvrD_C_2; pfam13538
553174002122	MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299
553174002123	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
553174002124	Ferritin-like domain; Region: Ferritin; pfam00210
553174002125	ferroxidase diiron center [ion binding]; other site
553174002126	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
553174002127	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
553174002128	homodimer interface [polypeptide binding]; other site
553174002129	substrate-cofactor binding pocket; other site
553174002130	catalytic residue [active]
553174002131	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
553174002132	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
553174002133	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
553174002134	generic binding surface II; other site
553174002135	generic binding surface I; other site
553174002136	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
553174002137	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
553174002138	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
553174002139	active site
553174002140	catalytic triad [active]
553174002141	Uncharacterized conserved protein [Function unknown]; Region: COG2966
553174002142	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
553174002143	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
553174002144	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
553174002145	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
553174002146	DEAD-like helicases superfamily; Region: DEXDc; smart00487
553174002147	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
553174002148	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
553174002149	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174002150	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174002151	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
553174002152	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
553174002153	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174002154	active site
553174002155	DNA binding site [nucleotide binding]
553174002156	Int/Topo IB signature motif; other site
553174002157	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
553174002158	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
553174002159	tandem repeat interface [polypeptide binding]; other site
553174002160	oligomer interface [polypeptide binding]; other site
553174002161	active site residues [active]
553174002162	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
553174002163	tandem repeat interface [polypeptide binding]; other site
553174002164	oligomer interface [polypeptide binding]; other site
553174002165	active site residues [active]
553174002166	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
553174002167	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
553174002168	purine nucleoside phosphorylase; Provisional; Region: PRK08202
553174002169	thiamine-monophosphate kinase; Region: thiL; TIGR01379
553174002170	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
553174002171	ATP binding site [chemical binding]; other site
553174002172	dimerization interface [polypeptide binding]; other site
553174002173	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174002174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174002175	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
553174002176	active site
553174002177	catalytic triad [active]
553174002178	oxyanion hole [active]
553174002179	Domain of unknown function (DUF303); Region: DUF303; pfam03629
553174002180	Sulfatase; Region: Sulfatase; cl17466
553174002181	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
553174002182	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
553174002183	Sulfatase; Region: Sulfatase; pfam00884
553174002184	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
553174002185	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
553174002186	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174002188	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
553174002189	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
553174002190	ring oligomerisation interface [polypeptide binding]; other site
553174002191	ATP/Mg binding site [chemical binding]; other site
553174002192	stacking interactions; other site
553174002193	hinge regions; other site
553174002194	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
553174002195	oligomerisation interface [polypeptide binding]; other site
553174002196	mobile loop; other site
553174002197	roof hairpin; other site
553174002198	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
553174002199	A new structural DNA glycosylase; Region: AlkD_like; cd06561
553174002200	active site
553174002201	Transposase, Mutator family; Region: Transposase_mut; pfam00872
553174002202	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174002203	active site
553174002204	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
553174002205	DHH family; Region: DHH; pfam01368
553174002206	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
553174002207	putative FMN binding site [chemical binding]; other site
553174002208	hypothetical protein; Provisional; Region: PRK11770
553174002209	Domain of unknown function (DUF307); Region: DUF307; pfam03733
553174002210	Domain of unknown function (DUF307); Region: DUF307; pfam03733
553174002211	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
553174002212	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
553174002213	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
553174002214	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
553174002215	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
553174002216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174002217	putative substrate translocation pore; other site
553174002218	POT family; Region: PTR2; cl17359
553174002219	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174002220	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
553174002221	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
553174002222	Family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine/isoleucine/valine- binding protein  (LIVBP)-like domain of the ionotropic glutamate recep; Region: PBP1_glutamate_receptors_like; cd06269
553174002223	dimerization interface [polypeptide binding]; other site
553174002224	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
553174002225	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
553174002226	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
553174002227	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
553174002228	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
553174002229	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
553174002230	dimerization interface [polypeptide binding]; other site
553174002231	putative active cleft [active]
553174002232	Low molecular weight phosphatase family; Region: LMWPc; cd00115
553174002233	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
553174002234	active site
553174002235	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
553174002236	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
553174002237	active site
553174002238	nucleophile elbow; other site
553174002239	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
553174002240	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
553174002241	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
553174002242	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
553174002243	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
553174002244	ATP-grasp domain; Region: ATP-grasp_4; cl17255
553174002245	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
553174002246	probable substrate binding site [chemical binding]; other site
553174002247	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
553174002248	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
553174002249	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
553174002250	catalytic site [active]
553174002251	subunit interface [polypeptide binding]; other site
553174002252	amidophosphoribosyltransferase; Region: purF; TIGR01134
553174002253	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
553174002254	active site
553174002255	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174002256	active site
553174002257	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
553174002258	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
553174002259	glutaminase active site [active]
553174002260	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
553174002261	dimer interface [polypeptide binding]; other site
553174002262	active site
553174002263	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
553174002264	dimer interface [polypeptide binding]; other site
553174002265	active site
553174002266	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
553174002267	SLBB domain; Region: SLBB; pfam10531
553174002268	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
553174002269	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
553174002270	putative active site [active]
553174002271	putative metal binding site [ion binding]; other site
553174002272	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
553174002273	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
553174002274	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
553174002275	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
553174002276	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
553174002277	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
553174002278	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
553174002279	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
553174002280	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
553174002281	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
553174002282	catalytic center binding site [active]
553174002283	ATP binding site [chemical binding]; other site
553174002284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
553174002285	binding surface
553174002286	TPR motif; other site
553174002287	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
553174002288	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
553174002289	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
553174002290	inhibitor-cofactor binding pocket; inhibition site
553174002291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174002292	catalytic residue [active]
553174002293	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
553174002294	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
553174002295	diaminopimelate decarboxylase; Region: PLN02537
553174002296	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
553174002297	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174002298	catalytic residue [active]
553174002299	Bacterial sugar transferase; Region: Bac_transf; pfam02397
553174002300	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
553174002301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174002302	NAD(P) binding site [chemical binding]; other site
553174002303	active site
553174002304	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
553174002305	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
553174002306	active site
553174002307	catalytic tetrad [active]
553174002308	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
553174002309	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
553174002310	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
553174002311	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
553174002312	putative ADP-binding pocket [chemical binding]; other site
553174002313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174002314	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174002315	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
553174002316	putative ADP-binding pocket [chemical binding]; other site
553174002317	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174002318	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174002319	active site
553174002320	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
553174002321	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
553174002322	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174002323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174002324	active site
553174002325	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
553174002326	trimer interface [polypeptide binding]; other site
553174002327	active site
553174002328	substrate binding site [chemical binding]; other site
553174002329	CoA binding site [chemical binding]; other site
553174002330	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174002331	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174002332	active site
553174002333	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
553174002334	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
553174002335	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
553174002336	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
553174002337	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
553174002338	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
553174002339	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174002340	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
553174002341	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
553174002342	putative active site [active]
553174002343	substrate binding site [chemical binding]; other site
553174002344	putative cosubstrate binding site; other site
553174002345	catalytic site [active]
553174002346	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
553174002347	substrate binding site [chemical binding]; other site
553174002348	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
553174002349	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
553174002350	Cl- selectivity filter; other site
553174002351	Cl- binding residues [ion binding]; other site
553174002352	pore gating glutamate residue; other site
553174002353	dimer interface [polypeptide binding]; other site
553174002354	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
553174002355	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
553174002356	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
553174002357	nucleotide binding site [chemical binding]; other site
553174002358	LysE type translocator; Region: LysE; cl00565
553174002359	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
553174002360	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
553174002361	NADP binding site [chemical binding]; other site
553174002362	active site
553174002363	putative substrate binding site [chemical binding]; other site
553174002364	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
553174002365	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
553174002366	G1 box; other site
553174002367	putative GEF interaction site [polypeptide binding]; other site
553174002368	GTP/Mg2+ binding site [chemical binding]; other site
553174002369	Switch I region; other site
553174002370	G2 box; other site
553174002371	G3 box; other site
553174002372	Switch II region; other site
553174002373	G4 box; other site
553174002374	G5 box; other site
553174002375	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
553174002376	RNA polymerase sigma factor; Provisional; Region: PRK12513
553174002377	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174002378	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174002379	DNA binding residues [nucleotide binding]
553174002380	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
553174002381	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
553174002382	substrate binding site [chemical binding]; other site
553174002383	hexamer interface [polypeptide binding]; other site
553174002384	metal binding site [ion binding]; metal-binding site
553174002385	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
553174002386	active site
553174002387	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
553174002388	Glutamine amidotransferase class-I; Region: GATase; pfam00117
553174002389	glutamine binding [chemical binding]; other site
553174002390	catalytic triad [active]
553174002391	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
553174002392	N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795
553174002393	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
553174002394	putative active site [active]
553174002395	catalytic site [active]
553174002396	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
553174002397	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174002398	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
553174002399	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
553174002400	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
553174002401	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
553174002402	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
553174002403	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
553174002404	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
553174002405	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
553174002406	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
553174002407	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
553174002408	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
553174002409	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
553174002410	GMP synthase; Reviewed; Region: guaA; PRK00074
553174002411	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
553174002412	AMP/PPi binding site [chemical binding]; other site
553174002413	candidate oxyanion hole; other site
553174002414	catalytic triad [active]
553174002415	potential glutamine specificity residues [chemical binding]; other site
553174002416	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
553174002417	ATP Binding subdomain [chemical binding]; other site
553174002418	Ligand Binding sites [chemical binding]; other site
553174002419	Dimerization subdomain; other site
553174002420	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
553174002421	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
553174002422	Substrate binding site; other site
553174002423	metal-binding site
553174002424	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
553174002425	DNA binding site [nucleotide binding]
553174002426	active site
553174002427	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
553174002428	catalytic residues [active]
553174002429	dimer interface [polypeptide binding]; other site
553174002430	Predicted membrane protein [Function unknown]; Region: COG4270
553174002431	Protein of unknown function DUF262; Region: DUF262; pfam03235
553174002432	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
553174002433	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
553174002434	active site
553174002435	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
553174002436	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466
553174002437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174002438	FeS/SAM binding site; other site
553174002439	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
553174002440	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
553174002441	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
553174002442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174002443	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
553174002444	Walker A motif; other site
553174002445	ATP binding site [chemical binding]; other site
553174002446	Walker B motif; other site
553174002447	arginine finger; other site
553174002448	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
553174002449	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
553174002450	Lipopolysaccharide-assembly; Region: LptE; pfam04390
553174002451	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
553174002452	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
553174002453	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
553174002454	active site
553174002455	substrate binding site [chemical binding]; other site
553174002456	metal binding site [ion binding]; metal-binding site
553174002457	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
553174002458	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
553174002459	active site
553174002460	nucleophile elbow; other site
553174002461	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
553174002462	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
553174002463	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
553174002464	active site
553174002465	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
553174002466	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
553174002467	DHH family; Region: DHH; pfam01368
553174002468	DHHA1 domain; Region: DHHA1; pfam02272
553174002469	DEAD-like helicases superfamily; Region: DEXDc; smart00487
553174002470	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174002471	ATP binding site [chemical binding]; other site
553174002472	putative Mg++ binding site [ion binding]; other site
553174002473	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174002474	nucleotide binding region [chemical binding]; other site
553174002475	ATP-binding site [chemical binding]; other site
553174002476	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
553174002477	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
553174002478	active site
553174002479	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174002480	ligand binding site [chemical binding]; other site
553174002481	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
553174002482	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
553174002483	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
553174002484	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
553174002485	TPP-binding site [chemical binding]; other site
553174002486	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
553174002487	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
553174002488	dimer interface [polypeptide binding]; other site
553174002489	PYR/PP interface [polypeptide binding]; other site
553174002490	TPP binding site [chemical binding]; other site
553174002491	substrate binding site [chemical binding]; other site
553174002492	Ferredoxin [Energy production and conversion]; Region: COG1146
553174002493	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
553174002494	TPR repeat; Region: TPR_11; pfam13414
553174002495	Tetratricopeptide repeat; Region: TPR_1; pfam00515
553174002496	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
553174002497	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
553174002498	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
553174002499	homodimer interface [polypeptide binding]; other site
553174002500	NADP binding site [chemical binding]; other site
553174002501	substrate binding site [chemical binding]; other site
553174002502	signal recognition particle protein; Provisional; Region: PRK10867
553174002503	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
553174002504	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
553174002505	P loop; other site
553174002506	GTP binding site [chemical binding]; other site
553174002507	Signal peptide binding domain; Region: SRP_SPB; pfam02978
553174002508	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
553174002509	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
553174002510	heterodimer interface [polypeptide binding]; other site
553174002511	active site
553174002512	FMN binding site [chemical binding]; other site
553174002513	homodimer interface [polypeptide binding]; other site
553174002514	substrate binding site [chemical binding]; other site
553174002515	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
553174002516	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
553174002517	FAD binding pocket [chemical binding]; other site
553174002518	FAD binding motif [chemical binding]; other site
553174002519	phosphate binding motif [ion binding]; other site
553174002520	beta-alpha-beta structure motif; other site
553174002521	NAD binding pocket [chemical binding]; other site
553174002522	Iron coordination center [ion binding]; other site
553174002523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174002524	non-specific DNA binding site [nucleotide binding]; other site
553174002525	salt bridge; other site
553174002526	sequence-specific DNA binding site [nucleotide binding]; other site
553174002527	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
553174002528	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
553174002529	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
553174002530	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
553174002531	putative metal binding site [ion binding]; other site
553174002532	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
553174002533	HSP70 interaction site [polypeptide binding]; other site
553174002534	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
553174002535	active site
553174002536	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
553174002537	TM2 domain; Region: TM2; pfam05154
553174002538	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
553174002539	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
553174002540	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
553174002541	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
553174002542	putative active site; other site
553174002543	catalytic triad [active]
553174002544	putative dimer interface [polypeptide binding]; other site
553174002545	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
553174002546	dimer interface [polypeptide binding]; other site
553174002547	active site
553174002548	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
553174002549	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
553174002550	peptidase T; Region: peptidase-T; TIGR01882
553174002551	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
553174002552	metal binding site [ion binding]; metal-binding site
553174002553	dimer interface [polypeptide binding]; other site
553174002554	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
553174002555	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
553174002556	TrkA-C domain; Region: TrkA_C; pfam02080
553174002557	TrkA-C domain; Region: TrkA_C; pfam02080
553174002558	Part of AAA domain; Region: AAA_19; pfam13245
553174002559	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
553174002560	AAA domain; Region: AAA_12; pfam13087
553174002561	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
553174002562	Uncharacterized conserved protein [Function unknown]; Region: COG0327
553174002563	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
553174002564	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
553174002565	Putative zinc ribbon domain; Region: DUF164; pfam02591
553174002566	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
553174002567	FMN binding site [chemical binding]; other site
553174002568	dimer interface [polypeptide binding]; other site
553174002569	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
553174002570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
553174002571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174002572	homodimer interface [polypeptide binding]; other site
553174002573	catalytic residue [active]
553174002574	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
553174002575	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
553174002576	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
553174002577	catalytic residue [active]
553174002578	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
553174002579	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
553174002580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174002581	Walker A motif; other site
553174002582	ATP binding site [chemical binding]; other site
553174002583	Walker B motif; other site
553174002584	arginine finger; other site
553174002585	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
553174002586	Septum formation initiator; Region: DivIC; cl17659
553174002587	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
553174002588	dihydroorotase; Reviewed; Region: PRK09236
553174002589	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
553174002590	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
553174002591	active site
553174002592	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
553174002593	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
553174002594	putative active site [active]
553174002595	putative metal binding site [ion binding]; other site
553174002596	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
553174002597	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
553174002598	putative acyl-acceptor binding pocket; other site
553174002599	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
553174002600	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
553174002601	Ligand binding site; other site
553174002602	Putative Catalytic site; other site
553174002603	DXD motif; other site
553174002604	hypothetical protein; Provisional; Region: PRK08201
553174002605	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
553174002606	metal binding site [ion binding]; metal-binding site
553174002607	putative dimer interface [polypeptide binding]; other site
553174002608	HEPN domain; Region: HEPN; cl00824
553174002609	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
553174002610	active site
553174002611	NTP binding site [chemical binding]; other site
553174002612	metal binding triad [ion binding]; metal-binding site
553174002613	antibiotic binding site [chemical binding]; other site
553174002614	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
553174002615	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
553174002616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174002617	ATP binding site [chemical binding]; other site
553174002618	putative Mg++ binding site [ion binding]; other site
553174002619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174002620	nucleotide binding region [chemical binding]; other site
553174002621	ATP-binding site [chemical binding]; other site
553174002622	TRCF domain; Region: TRCF; pfam03461
553174002623	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
553174002624	conserved cys residue [active]
553174002625	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
553174002626	catalytic core [active]
553174002627	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
553174002628	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
553174002629	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
553174002630	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174002631	catalytic residues [active]
553174002632	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
553174002633	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
553174002634	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
553174002635	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
553174002636	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
553174002637	ligand binding site [chemical binding]; other site
553174002638	flexible hinge region; other site
553174002639	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
553174002640	putative switch regulator; other site
553174002641	non-specific DNA interactions [nucleotide binding]; other site
553174002642	DNA binding site [nucleotide binding]
553174002643	sequence specific DNA binding site [nucleotide binding]; other site
553174002644	putative cAMP binding site [chemical binding]; other site
553174002645	Hemerythrin-like domain; Region: Hr-like; cd12108
553174002646	Fe binding site [ion binding]; other site
553174002647	Uncharacterized conserved protein [Function unknown]; Region: COG3189
553174002648	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
553174002649	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
553174002650	putative dimer interface [polypeptide binding]; other site
553174002651	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
553174002652	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
553174002653	CoA-binding site [chemical binding]; other site
553174002654	ATP-binding [chemical binding]; other site
553174002655	YbbR-like protein; Region: YbbR; pfam07949
553174002656	Preprotein translocase subunit; Region: YajC; pfam02699
553174002657	transcription antitermination factor NusB; Region: nusB; TIGR01951
553174002658	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
553174002659	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
553174002660	5S rRNA interface [nucleotide binding]; other site
553174002661	CTC domain interface [polypeptide binding]; other site
553174002662	L16 interface [polypeptide binding]; other site
553174002663	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
553174002664	putative active site [active]
553174002665	catalytic residue [active]
553174002666	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
553174002667	RNA binding surface [nucleotide binding]; other site
553174002668	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
553174002669	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
553174002670	metal binding site [ion binding]; metal-binding site
553174002671	dimer interface [polypeptide binding]; other site
553174002672	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
553174002673	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
553174002674	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
553174002675	S-adenosylmethionine binding site [chemical binding]; other site
553174002676	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
553174002677	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
553174002678	ribosome recycling factor; Reviewed; Region: frr; PRK00083
553174002679	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
553174002680	hinge region; other site
553174002681	GTPase RsgA; Reviewed; Region: PRK00098
553174002682	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
553174002683	RNA binding site [nucleotide binding]; other site
553174002684	homodimer interface [polypeptide binding]; other site
553174002685	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
553174002686	GTPase/Zn-binding domain interface [polypeptide binding]; other site
553174002687	GTP/Mg2+ binding site [chemical binding]; other site
553174002688	G4 box; other site
553174002689	G5 box; other site
553174002690	G1 box; other site
553174002691	Switch I region; other site
553174002692	G2 box; other site
553174002693	G3 box; other site
553174002694	Switch II region; other site
553174002695	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
553174002696	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
553174002697	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174002698	motif II; other site
553174002699	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
553174002700	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
553174002701	active site
553174002702	dimer interface [polypeptide binding]; other site
553174002703	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
553174002704	dimer interface [polypeptide binding]; other site
553174002705	active site
553174002706	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
553174002707	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
553174002708	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
553174002709	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
553174002710	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
553174002711	dimer interface [polypeptide binding]; other site
553174002712	putative anticodon binding site; other site
553174002713	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
553174002714	motif 1; other site
553174002715	active site
553174002716	motif 2; other site
553174002717	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
553174002718	motif 3; other site
553174002719	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
553174002720	CoenzymeA binding site [chemical binding]; other site
553174002721	subunit interaction site [polypeptide binding]; other site
553174002722	PHB binding site; other site
553174002723	chorismate binding enzyme; Region: Chorismate_bind; cl10555
553174002724	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
553174002725	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
553174002726	dimer interface [polypeptide binding]; other site
553174002727	tetramer interface [polypeptide binding]; other site
553174002728	PYR/PP interface [polypeptide binding]; other site
553174002729	TPP binding site [chemical binding]; other site
553174002730	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
553174002731	TPP-binding site [chemical binding]; other site
553174002732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
553174002733	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
553174002734	substrate binding site [chemical binding]; other site
553174002735	oxyanion hole (OAH) forming residues; other site
553174002736	trimer interface [polypeptide binding]; other site
553174002737	GxxExxY protein; Region: GxxExxY; TIGR04256
553174002738	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
553174002739	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
553174002740	active site
553174002741	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
553174002742	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174002743	acyl-activating enzyme (AAE) consensus motif; other site
553174002744	AMP binding site [chemical binding]; other site
553174002745	active site
553174002746	CoA binding site [chemical binding]; other site
553174002747	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
553174002748	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
553174002749	Cl binding site [ion binding]; other site
553174002750	oligomer interface [polypeptide binding]; other site
553174002751	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
553174002752	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
553174002753	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
553174002754	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
553174002755	active site residue [active]
553174002756	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
553174002757	FtsH Extracellular; Region: FtsH_ext; pfam06480
553174002758	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
553174002759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174002760	Walker A motif; other site
553174002761	ATP binding site [chemical binding]; other site
553174002762	Walker B motif; other site
553174002763	arginine finger; other site
553174002764	Peptidase family M41; Region: Peptidase_M41; pfam01434
553174002765	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
553174002766	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
553174002767	SprT homologues; Region: SprT; cl01182
553174002768	SprT-like family; Region: SprT-like; pfam10263
553174002769	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
553174002770	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
553174002771	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
553174002772	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
553174002773	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
553174002774	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174002775	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174002776	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174002777	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174002778	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174002779	SusD family; Region: SusD; pfam07980
553174002780	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
553174002781	trimer interface [polypeptide binding]; other site
553174002782	active site
553174002783	G bulge; other site
553174002784	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
553174002785	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
553174002786	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
553174002787	Abi-like protein; Region: Abi_2; pfam07751
553174002788	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
553174002789	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
553174002790	DNA binding residues [nucleotide binding]
553174002791	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
553174002792	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
553174002793	motif 1; other site
553174002794	active site
553174002795	motif 2; other site
553174002796	motif 3; other site
553174002797	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
553174002798	DHHA1 domain; Region: DHHA1; pfam02272
553174002799	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
553174002800	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
553174002801	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
553174002802	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
553174002803	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
553174002804	P-loop; other site
553174002805	Magnesium ion binding site [ion binding]; other site
553174002806	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
553174002807	Magnesium ion binding site [ion binding]; other site
553174002808	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
553174002809	ParB-like nuclease domain; Region: ParBc; pfam02195
553174002810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
553174002811	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
553174002812	N-acetyl-D-glucosamine binding site [chemical binding]; other site
553174002813	catalytic residue [active]
553174002814	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
553174002815	HD domain; Region: HD_4; pfam13328
553174002816	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
553174002817	synthetase active site [active]
553174002818	NTP binding site [chemical binding]; other site
553174002819	metal binding site [ion binding]; metal-binding site
553174002820	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
553174002821	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
553174002822	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174002823	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174002824	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174002825	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174002826	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174002827	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174002828	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
553174002829	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174002830	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174002831	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174002832	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174002833	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
553174002834	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
553174002835	DNA binding residues [nucleotide binding]
553174002836	dimerization interface [polypeptide binding]; other site
553174002837	LrgB-like family; Region: LrgB; pfam04172
553174002838	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
553174002839	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
553174002840	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
553174002841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174002842	S-adenosylmethionine binding site [chemical binding]; other site
553174002843	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
553174002844	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
553174002845	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
553174002846	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
553174002847	putative active site [active]
553174002848	catalytic site [active]
553174002849	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
553174002850	putative active site [active]
553174002851	catalytic site [active]
553174002852	transcriptional regulator MalT; Provisional; Region: PRK04841
553174002853	DNA primase, catalytic core; Region: dnaG; TIGR01391
553174002854	CHC2 zinc finger; Region: zf-CHC2; pfam01807
553174002855	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
553174002856	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
553174002857	active site
553174002858	metal binding site [ion binding]; metal-binding site
553174002859	interdomain interaction site; other site
553174002860	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
553174002861	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
553174002862	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
553174002863	Ligand binding site [chemical binding]; other site
553174002864	Electron transfer flavoprotein domain; Region: ETF; pfam01012
553174002865	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
553174002866	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
553174002867	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
553174002868	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
553174002869	putative active site [active]
553174002870	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
553174002871	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
553174002872	active site
553174002873	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
553174002874	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
553174002875	Mechanosensitive ion channel; Region: MS_channel; pfam00924
553174002876	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
553174002877	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
553174002878	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
553174002879	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
553174002880	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
553174002881	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
553174002882	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
553174002883	RuvA N terminal domain; Region: RuvA_N; pfam01330
553174002884	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
553174002885	cell surface protein SprA; Region: surface_SprA; TIGR04189
553174002886	Motility related/secretion protein; Region: SprA_N; pfam14349
553174002887	Motility related/secretion protein; Region: SprA_N; pfam14349
553174002888	Motility related/secretion protein; Region: SprA_N; pfam14349
553174002889	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
553174002890	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
553174002891	dimer interface [polypeptide binding]; other site
553174002892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174002893	catalytic residue [active]
553174002894	AAA domain; Region: AAA_21; pfam13304
553174002895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174002896	ABC transporter signature motif; other site
553174002897	Walker B; other site
553174002898	D-loop; other site
553174002899	H-loop/switch region; other site
553174002900	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
553174002901	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
553174002902	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
553174002903	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
553174002904	active site
553174002905	metal binding site [ion binding]; metal-binding site
553174002906	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
553174002907	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
553174002908	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
553174002909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174002910	ATP binding site [chemical binding]; other site
553174002911	putative Mg++ binding site [ion binding]; other site
553174002912	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
553174002913	Abortive infection C-terminus; Region: Abi_C; pfam14355
553174002914	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174002915	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174002916	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174002917	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174002918	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174002919	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174002920	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174002921	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
553174002922	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174002923	active site
553174002924	DNA binding site [nucleotide binding]
553174002925	Int/Topo IB signature motif; other site
553174002926	HsdM N-terminal domain; Region: HsdM_N; pfam12161
553174002927	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
553174002928	Methyltransferase domain; Region: Methyltransf_26; pfam13659
553174002929	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
553174002930	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174002931	non-specific DNA binding site [nucleotide binding]; other site
553174002932	salt bridge; other site
553174002933	sequence-specific DNA binding site [nucleotide binding]; other site
553174002934	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
553174002935	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
553174002936	CHC2 zinc finger; Region: zf-CHC2; cl17510
553174002937	Toprim-like; Region: Toprim_2; pfam13155
553174002938	Virulence-associated protein E; Region: VirE; pfam05272
553174002939	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174002940	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
553174002941	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
553174002942	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
553174002943	Int/Topo IB signature motif; other site
553174002944	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
553174002945	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174002946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
553174002947	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
553174002948	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
553174002949	nucleotide binding site [chemical binding]; other site
553174002950	NEF interaction site [polypeptide binding]; other site
553174002951	SBD interface [polypeptide binding]; other site
553174002952	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
553174002953	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
553174002954	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
553174002955	TrkA-N domain; Region: TrkA_N; pfam02254
553174002956	TrkA-C domain; Region: TrkA_C; pfam02080
553174002957	TrkA-N domain; Region: TrkA_N; pfam02254
553174002958	TrkA-C domain; Region: TrkA_C; pfam02080
553174002959	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
553174002960	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
553174002961	TPP-binding site; other site
553174002962	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
553174002963	PYR/PP interface [polypeptide binding]; other site
553174002964	dimer interface [polypeptide binding]; other site
553174002965	TPP binding site [chemical binding]; other site
553174002966	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
553174002967	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174002968	ligand binding site [chemical binding]; other site
553174002969	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174002970	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
553174002971	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
553174002972	glycyl-tRNA synthetase; Provisional; Region: PRK04173
553174002973	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
553174002974	motif 1; other site
553174002975	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
553174002976	active site
553174002977	motif 2; other site
553174002978	motif 3; other site
553174002979	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
553174002980	anticodon binding site; other site
553174002981	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
553174002982	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
553174002983	CAP-like domain; other site
553174002984	active site
553174002985	primary dimer interface [polypeptide binding]; other site
553174002986	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
553174002987	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
553174002988	active site triad [active]
553174002989	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174002990	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
553174002991	adenylosuccinate lyase; Provisional; Region: PRK09285
553174002992	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
553174002993	tetramer interface [polypeptide binding]; other site
553174002994	active site
553174002995	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
553174002996	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
553174002997	RNA binding surface [nucleotide binding]; other site
553174002998	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
553174002999	active site
553174003000	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
553174003001	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
553174003002	putative dimer interface [polypeptide binding]; other site
553174003003	putative anticodon binding site; other site
553174003004	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
553174003005	homodimer interface [polypeptide binding]; other site
553174003006	motif 1; other site
553174003007	motif 2; other site
553174003008	active site
553174003009	motif 3; other site
553174003010	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
553174003011	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
553174003012	dimer interface [polypeptide binding]; other site
553174003013	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
553174003014	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
553174003015	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
553174003016	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
553174003017	putative ATP binding site [chemical binding]; other site
553174003018	putative substrate interface [chemical binding]; other site
553174003019	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174003020	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
553174003021	S1 domain; Region: S1_2; pfam13509
553174003022	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
553174003023	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
553174003024	Walker A/P-loop; other site
553174003025	ATP binding site [chemical binding]; other site
553174003026	Q-loop/lid; other site
553174003027	ABC transporter signature motif; other site
553174003028	Walker B; other site
553174003029	D-loop; other site
553174003030	H-loop/switch region; other site
553174003031	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
553174003032	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
553174003033	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
553174003034	Ligand Binding Site [chemical binding]; other site
553174003035	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
553174003036	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
553174003037	Uncharacterized conserved protein [Function unknown]; Region: COG1359
553174003038	FMN-binding domain; Region: FMN_bind; pfam04205
553174003039	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
553174003040	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
553174003041	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
553174003042	lipoyl synthase; Provisional; Region: PRK05481
553174003043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174003044	FeS/SAM binding site; other site
553174003045	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
553174003046	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174003047	ligand binding site [chemical binding]; other site
553174003048	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
553174003049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174003050	ATP binding site [chemical binding]; other site
553174003051	Mg2+ binding site [ion binding]; other site
553174003052	G-X-G motif; other site
553174003053	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
553174003054	ATP binding site [chemical binding]; other site
553174003055	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
553174003056	OstA-like protein; Region: OstA_2; pfam13100
553174003057	OstA-like protein; Region: OstA; cl00844
553174003058	OstA-like protein; Region: OstA; cl00844
553174003059	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
553174003060	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
553174003061	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
553174003062	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
553174003063	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
553174003064	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
553174003065	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
553174003066	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
553174003067	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
553174003068	active site
553174003069	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
553174003070	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
553174003071	dimerization interface [polypeptide binding]; other site
553174003072	DPS ferroxidase diiron center [ion binding]; other site
553174003073	ion pore; other site
553174003074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
553174003075	sequence-specific DNA binding site [nucleotide binding]; other site
553174003076	salt bridge; other site
553174003077	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
553174003078	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
553174003079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174003080	ATP binding site [chemical binding]; other site
553174003081	putative Mg++ binding site [ion binding]; other site
553174003082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174003083	nucleotide binding region [chemical binding]; other site
553174003084	ATP-binding site [chemical binding]; other site
553174003085	RQC domain; Region: RQC; pfam09382
553174003086	HRDC domain; Region: HRDC; pfam00570
553174003087	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
553174003088	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
553174003089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174003090	Walker A motif; other site
553174003091	ATP binding site [chemical binding]; other site
553174003092	Walker B motif; other site
553174003093	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
553174003094	Clp protease; Region: CLP_protease; pfam00574
553174003095	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
553174003096	oligomer interface [polypeptide binding]; other site
553174003097	active site residues [active]
553174003098	trigger factor; Region: tig; TIGR00115
553174003099	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
553174003100	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
553174003101	Walker A/P-loop; other site
553174003102	ATP binding site [chemical binding]; other site
553174003103	Q-loop/lid; other site
553174003104	ABC transporter signature motif; other site
553174003105	Walker B; other site
553174003106	D-loop; other site
553174003107	H-loop/switch region; other site
553174003108	Transposase IS200 like; Region: Y1_Tnp; cl00848
553174003109	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
553174003110	Permease; Region: Permease; pfam02405
553174003111	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
553174003112	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
553174003113	Walker A/P-loop; other site
553174003114	ATP binding site [chemical binding]; other site
553174003115	Q-loop/lid; other site
553174003116	ABC transporter signature motif; other site
553174003117	Walker B; other site
553174003118	D-loop; other site
553174003119	H-loop/switch region; other site
553174003120	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
553174003121	GTP-binding protein Der; Reviewed; Region: PRK00093
553174003122	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
553174003123	G1 box; other site
553174003124	GTP/Mg2+ binding site [chemical binding]; other site
553174003125	Switch I region; other site
553174003126	G2 box; other site
553174003127	Switch II region; other site
553174003128	G3 box; other site
553174003129	G4 box; other site
553174003130	G5 box; other site
553174003131	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
553174003132	G1 box; other site
553174003133	GTP/Mg2+ binding site [chemical binding]; other site
553174003134	Switch I region; other site
553174003135	G2 box; other site
553174003136	G3 box; other site
553174003137	Switch II region; other site
553174003138	G4 box; other site
553174003139	G5 box; other site
553174003140	GTPase Era; Reviewed; Region: era; PRK00089
553174003141	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
553174003142	G1 box; other site
553174003143	GTP/Mg2+ binding site [chemical binding]; other site
553174003144	Switch I region; other site
553174003145	G2 box; other site
553174003146	Switch II region; other site
553174003147	G3 box; other site
553174003148	G4 box; other site
553174003149	G5 box; other site
553174003150	KH domain; Region: KH_2; pfam07650
553174003151	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
553174003152	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
553174003153	dimer interface [polypeptide binding]; other site
553174003154	active site
553174003155	CoA binding pocket [chemical binding]; other site
553174003156	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
553174003157	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
553174003158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
553174003159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174003160	ATP binding site [chemical binding]; other site
553174003161	Mg2+ binding site [ion binding]; other site
553174003162	G-X-G motif; other site
553174003163	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174003164	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
553174003165	acyl-activating enzyme (AAE) consensus motif; other site
553174003166	AMP binding site [chemical binding]; other site
553174003167	active site
553174003168	CoA binding site [chemical binding]; other site
553174003169	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
553174003170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174003171	non-specific DNA binding site [nucleotide binding]; other site
553174003172	salt bridge; other site
553174003173	sequence-specific DNA binding site [nucleotide binding]; other site
553174003174	Cupin domain; Region: Cupin_2; pfam07883
553174003175	Arginine repressor [Transcription]; Region: ArgR; COG1438
553174003176	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
553174003177	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
553174003178	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
553174003179	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
553174003180	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
553174003181	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
553174003182	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
553174003183	ATP-grasp domain; Region: ATP-grasp_4; cl17255
553174003184	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
553174003185	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
553174003186	RNA binding surface [nucleotide binding]; other site
553174003187	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
553174003188	active site
553174003189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
553174003190	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
553174003191	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
553174003192	elongation factor P; Validated; Region: PRK00529
553174003193	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
553174003194	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
553174003195	RNA binding site [nucleotide binding]; other site
553174003196	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
553174003197	RNA binding site [nucleotide binding]; other site
553174003198	Competence protein CoiA-like family; Region: CoiA; cl11541
553174003199	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
553174003200	dihydropteroate synthase; Region: DHPS; TIGR01496
553174003201	substrate binding pocket [chemical binding]; other site
553174003202	dimer interface [polypeptide binding]; other site
553174003203	inhibitor binding site; inhibition site
553174003204	Uncharacterized conserved protein [Function unknown]; Region: COG1624
553174003205	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
553174003206	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
553174003207	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
553174003208	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
553174003209	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
553174003210	propionate/acetate kinase; Provisional; Region: PRK12379
553174003211	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
553174003212	putative active site [active]
553174003213	putative metal binding site [ion binding]; other site
553174003214	Domain of unknown function DUF59; Region: DUF59; cl00941
553174003215	hypothetical protein; Provisional; Region: PRK06771
553174003216	hypothetical protein; Reviewed; Region: PRK00024
553174003217	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
553174003218	MPN+ (JAMM) motif; other site
553174003219	Zinc-binding site [ion binding]; other site
553174003220	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
553174003221	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174003222	active site
553174003223	methionine gamma-lyase; Provisional; Region: PRK06767
553174003224	NigD-like protein; Region: NigD; pfam12667
553174003225	Spi protease inhibitor; Region: Inhibitor_I69; pfam13734
553174003226	Peptidase C10 family; Region: Peptidase_C10; pfam01640
553174003227	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174003228	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
553174003229	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
553174003230	substrate-cofactor binding pocket; other site
553174003231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174003232	catalytic residue [active]
553174003233	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
553174003234	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174003235	NAD(P) binding site [chemical binding]; other site
553174003236	active site
553174003237	SPFH domain / Band 7 family; Region: Band_7; pfam01145
553174003238	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
553174003239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
553174003240	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
553174003241	dimerization interface [polypeptide binding]; other site
553174003242	peroxiredoxin; Region: AhpC; TIGR03137
553174003243	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
553174003244	dimer interface [polypeptide binding]; other site
553174003245	decamer (pentamer of dimers) interface [polypeptide binding]; other site
553174003246	catalytic triad [active]
553174003247	peroxidatic and resolving cysteines [active]
553174003248	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
553174003249	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
553174003250	catalytic residue [active]
553174003251	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
553174003252	catalytic residues [active]
553174003253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
553174003254	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
553174003255	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
553174003256	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
553174003257	Soluble P-type ATPase [General function prediction only]; Region: COG4087
553174003258	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
553174003259	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
553174003260	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
553174003261	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
553174003262	FMN binding site [chemical binding]; other site
553174003263	active site
553174003264	catalytic residues [active]
553174003265	substrate binding site [chemical binding]; other site
553174003266	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
553174003267	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
553174003268	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
553174003269	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
553174003270	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
553174003271	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
553174003272	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
553174003273	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
553174003274	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
553174003275	Na2 binding site [ion binding]; other site
553174003276	putative substrate binding site 1 [chemical binding]; other site
553174003277	Na binding site 1 [ion binding]; other site
553174003278	putative substrate binding site 2 [chemical binding]; other site
553174003279	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
553174003280	putative active site [active]
553174003281	putative metal binding residues [ion binding]; other site
553174003282	signature motif; other site
553174003283	putative dimer interface [polypeptide binding]; other site
553174003284	putative phosphate binding site [ion binding]; other site
553174003285	peptide chain release factor 2; Validated; Region: prfB; PRK00578
553174003286	This domain is found in peptide chain release factors; Region: PCRF; smart00937
553174003287	RF-1 domain; Region: RF-1; pfam00472
553174003288	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
553174003289	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174003290	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
553174003291	acyl-activating enzyme (AAE) consensus motif; other site
553174003292	acyl-activating enzyme (AAE) consensus motif; other site
553174003293	putative AMP binding site [chemical binding]; other site
553174003294	putative active site [active]
553174003295	putative CoA binding site [chemical binding]; other site
553174003296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
553174003297	Peptidase family M23; Region: Peptidase_M23; pfam01551
553174003298	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
553174003299	Tetratricopeptide repeat; Region: TPR_12; pfam13424
553174003300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174003301	binding surface
553174003302	TPR motif; other site
553174003303	Tetratricopeptide repeat; Region: TPR_15; pfam13429
553174003304	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
553174003305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174003306	binding surface
553174003307	TPR motif; other site
553174003308	TPR repeat; Region: TPR_11; pfam13414
553174003309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174003310	binding surface
553174003311	TPR motif; other site
553174003312	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
553174003313	trimer interface [polypeptide binding]; other site
553174003314	active site
553174003315	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
553174003316	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
553174003317	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
553174003318	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
553174003319	AAA domain; Region: AAA_11; pfam13086
553174003320	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
553174003321	AAA domain; Region: AAA_12; pfam13087
553174003322	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
553174003323	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
553174003324	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174003325	active site
553174003326	HIGH motif; other site
553174003327	nucleotide binding site [chemical binding]; other site
553174003328	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
553174003329	KMSK motif region; other site
553174003330	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
553174003331	tRNA binding surface [nucleotide binding]; other site
553174003332	anticodon binding site; other site
553174003333	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
553174003334	active site
553174003335	RNA/DNA hybrid binding site [nucleotide binding]; other site
553174003336	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
553174003337	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
553174003338	NAD binding site [chemical binding]; other site
553174003339	homotetramer interface [polypeptide binding]; other site
553174003340	homodimer interface [polypeptide binding]; other site
553174003341	substrate binding site [chemical binding]; other site
553174003342	active site
553174003343	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
553174003344	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
553174003345	PLD-like domain; Region: PLDc_2; pfam13091
553174003346	putative homodimer interface [polypeptide binding]; other site
553174003347	putative active site [active]
553174003348	catalytic site [active]
553174003349	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
553174003350	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174003351	ATP binding site [chemical binding]; other site
553174003352	putative Mg++ binding site [ion binding]; other site
553174003353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174003354	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
553174003355	nucleotide binding region [chemical binding]; other site
553174003356	ATP-binding site [chemical binding]; other site
553174003357	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
553174003358	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
553174003359	Divergent AAA domain; Region: AAA_4; pfam04326
553174003360	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
553174003361	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
553174003362	Virulence protein [General function prediction only]; Region: COG3943
553174003363	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
553174003364	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
553174003365	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
553174003366	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
553174003367	Substrate binding site; other site
553174003368	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
553174003369	nucleotide binding site/active site [active]
553174003370	HIT family signature motif; other site
553174003371	catalytic residue [active]
553174003372	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
553174003373	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
553174003374	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
553174003375	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
553174003376	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
553174003377	predicted active site [active]
553174003378	catalytic triad [active]
553174003379	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
553174003380	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
553174003381	active site
553174003382	multimer interface [polypeptide binding]; other site
553174003383	Phosphomethylpyrimidine kinase; Region: Phos_pyr_kin; pfam08543
553174003384	substrate binding site [chemical binding]; other site
553174003385	ATP binding site [chemical binding]; other site
553174003386	Helix-turn-helix domain; Region: HTH_18; pfam12833
553174003387	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174003388	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003389	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174003390	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
553174003391	N-terminal plug; other site
553174003392	ligand-binding site [chemical binding]; other site
553174003393	alpha-galactosidase; Region: PLN02808; cl17638
553174003394	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
553174003395	starch binding site [chemical binding]; other site
553174003396	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174003397	SusD family; Region: SusD; pfam07980
553174003398	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174003399	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003400	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174003401	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003402	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
553174003403	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
553174003404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174003405	Walker A motif; other site
553174003406	ATP binding site [chemical binding]; other site
553174003407	Walker B motif; other site
553174003408	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
553174003409	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
553174003410	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
553174003411	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
553174003412	catalytic residues [active]
553174003413	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174003414	active site
553174003415	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
553174003416	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
553174003417	active site
553174003418	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
553174003419	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
553174003420	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
553174003421	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174003422	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174003423	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003424	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003425	comF family protein; Region: comF; TIGR00201
553174003426	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174003427	active site
553174003428	RecX family; Region: RecX; pfam02631
553174003429	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
553174003430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174003431	S-adenosylmethionine binding site [chemical binding]; other site
553174003432	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
553174003433	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
553174003434	catalytic motif [active]
553174003435	Zn binding site [ion binding]; other site
553174003436	RibD C-terminal domain; Region: RibD_C; cl17279
553174003437	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
553174003438	AAA domain; Region: AAA_11; pfam13086
553174003439	Part of AAA domain; Region: AAA_19; pfam13245
553174003440	AAA domain; Region: AAA_30; pfam13604
553174003441	AAA domain; Region: AAA_12; pfam13087
553174003442	Fic family protein [Function unknown]; Region: COG3177
553174003443	Fic/DOC family; Region: Fic; pfam02661
553174003444	Peptidase family C69; Region: Peptidase_C69; pfam03577
553174003445	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
553174003446	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
553174003447	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
553174003448	nucleophile elbow; other site
553174003449	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
553174003450	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
553174003451	active site
553174003452	K+ potassium transporter; Region: K_trans; pfam02705
553174003453	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
553174003454	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
553174003455	active site
553174003456	HIGH motif; other site
553174003457	KMSKS motif; other site
553174003458	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
553174003459	tRNA binding surface [nucleotide binding]; other site
553174003460	anticodon binding site; other site
553174003461	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
553174003462	dimer interface [polypeptide binding]; other site
553174003463	putative tRNA-binding site [nucleotide binding]; other site
553174003464	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
553174003465	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
553174003466	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
553174003467	Walker A/P-loop; other site
553174003468	ATP binding site [chemical binding]; other site
553174003469	Q-loop/lid; other site
553174003470	ABC transporter signature motif; other site
553174003471	Walker B; other site
553174003472	D-loop; other site
553174003473	H-loop/switch region; other site
553174003474	putative transporter; Validated; Region: PRK03818
553174003475	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
553174003476	TrkA-C domain; Region: TrkA_C; pfam02080
553174003477	TrkA-C domain; Region: TrkA_C; pfam02080
553174003478	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
553174003479	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
553174003480	substrate binding site [chemical binding]; other site
553174003481	ATP binding site [chemical binding]; other site
553174003482	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
553174003483	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
553174003484	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
553174003485	Protein export membrane protein; Region: SecD_SecF; cl14618
553174003486	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
553174003487	putative catalytic site [active]
553174003488	putative metal binding site [ion binding]; other site
553174003489	putative phosphate binding site [ion binding]; other site
553174003490	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
553174003491	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
553174003492	IHF - DNA interface [nucleotide binding]; other site
553174003493	IHF dimer interface [polypeptide binding]; other site
553174003494	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003495	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
553174003496	DNA binding site [nucleotide binding]
553174003497	alpha-galactosidase; Region: PLN02808; cl17638
553174003498	Membrane transport protein; Region: Mem_trans; cl09117
553174003499	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
553174003500	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
553174003501	phosphate binding site [ion binding]; other site
553174003502	Clostripain family; Region: Peptidase_C11; pfam03415
553174003503	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
553174003504	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
553174003505	active site
553174003506	HIGH motif; other site
553174003507	dimer interface [polypeptide binding]; other site
553174003508	KMSKS motif; other site
553174003509	Haemolytic domain; Region: Haemolytic; pfam01809
553174003510	ribonuclease P; Reviewed; Region: rnpA; PRK01903
553174003511	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
553174003512	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
553174003513	active site
553174003514	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
553174003515	S-adenosylmethionine synthetase; Validated; Region: PRK05250
553174003516	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
553174003517	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
553174003518	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
553174003519	Fic family protein [Function unknown]; Region: COG3177
553174003520	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
553174003521	Fic/DOC family; Region: Fic; pfam02661
553174003522	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174003523	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
553174003524	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174003525	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174003526	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174003527	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
553174003528	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
553174003529	active site
553174003530	Int/Topo IB signature motif; other site
553174003531	Dehydroquinase class II; Region: DHquinase_II; pfam01220
553174003532	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
553174003533	trimer interface [polypeptide binding]; other site
553174003534	active site
553174003535	dimer interface [polypeptide binding]; other site
553174003536	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
553174003537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174003538	S-adenosylmethionine binding site [chemical binding]; other site
553174003539	Ribosome-binding factor A; Region: RBFA; pfam02033
553174003540	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
553174003541	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
553174003542	FtsX-like permease family; Region: FtsX; pfam02687
553174003543	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
553174003544	Fic/DOC family; Region: Fic; pfam02661
553174003545	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
553174003546	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
553174003547	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
553174003548	putative homodimer interface [polypeptide binding]; other site
553174003549	putative active site pocket [active]
553174003550	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
553174003551	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174003552	Glycogen synthase; Region: Glycogen_syn; pfam05693
553174003553	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174003554	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
553174003555	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
553174003556	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
553174003557	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
553174003558	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
553174003559	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
553174003560	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
553174003561	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
553174003562	homodimer interface [polypeptide binding]; other site
553174003563	substrate-cofactor binding pocket; other site
553174003564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174003565	catalytic residue [active]
553174003566	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
553174003567	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
553174003568	putative DNA binding site [nucleotide binding]; other site
553174003569	putative Zn2+ binding site [ion binding]; other site
553174003570	AsnC family; Region: AsnC_trans_reg; pfam01037
553174003571	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
553174003572	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
553174003573	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
553174003574	PhoU domain; Region: PhoU; pfam01895
553174003575	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
553174003576	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
553174003577	active site
553174003578	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
553174003579	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
553174003580	active site
553174003581	HIGH motif; other site
553174003582	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
553174003583	active site
553174003584	KMSKS motif; other site
553174003585	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
553174003586	tRNA binding surface [nucleotide binding]; other site
553174003587	anticodon binding site; other site
553174003588	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
553174003589	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
553174003590	active site
553174003591	catalytic motif [active]
553174003592	Zn binding site [ion binding]; other site
553174003593	glutamate racemase; Provisional; Region: PRK00865
553174003594	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
553174003595	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
553174003596	periplasmic chaperone; Provisional; Region: PRK10780
553174003597	periplasmic chaperone; Provisional; Region: PRK10780
553174003598	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
553174003599	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
553174003600	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
553174003601	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
553174003602	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
553174003603	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
553174003604	Surface antigen; Region: Bac_surface_Ag; pfam01103
553174003605	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838
553174003606	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
553174003607	catalytic residue [active]
553174003608	putative FPP diphosphate  binding site; other site
553174003609	putative FPP binding hydrophobic cleft; other site
553174003610	dimer interface [polypeptide binding]; other site
553174003611	putative IPP diphosphate binding site; other site
553174003612	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174003613	KilA-N domain; Region: KilA-N; pfam04383
553174003614	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
553174003615	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
553174003616	active site
553174003617	substrate-binding site [chemical binding]; other site
553174003618	metal-binding site [ion binding]
553174003619	ATP binding site [chemical binding]; other site
553174003620	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174003621	active site
553174003622	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
553174003623	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
553174003624	Active site serine [active]
553174003625	LemA family; Region: LemA; cl00742
553174003626	Methyltransferase domain; Region: Methyltransf_31; pfam13847
553174003627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174003628	S-adenosylmethionine binding site [chemical binding]; other site
553174003629	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
553174003630	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174003631	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174003632	DNA binding residues [nucleotide binding]
553174003633	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174003634	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
553174003635	LytTr DNA-binding domain; Region: LytTR; smart00850
553174003636	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
553174003637	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
553174003638	TPP-binding site [chemical binding]; other site
553174003639	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
553174003640	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
553174003641	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
553174003642	dimer interface [polypeptide binding]; other site
553174003643	PYR/PP interface [polypeptide binding]; other site
553174003644	TPP binding site [chemical binding]; other site
553174003645	substrate binding site [chemical binding]; other site
553174003646	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
553174003647	active site
553174003648	catalytic residues [active]
553174003649	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
553174003650	putative active site [active]
553174003651	putative catalytic site [active]
553174003652	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
553174003653	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
553174003654	Ligand binding site; other site
553174003655	Putative Catalytic site; other site
553174003656	DXD motif; other site
553174003657	Predicted membrane protein [Function unknown]; Region: COG2246
553174003658	GtrA-like protein; Region: GtrA; pfam04138
553174003659	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
553174003660	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174003661	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
553174003662	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
553174003663	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
553174003664	metal-binding site
553174003665	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174003666	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
553174003667	putative metal binding site; other site
553174003668	Sulfatase; Region: Sulfatase; cl17466
553174003669	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
553174003670	GDP-Fucose binding site [chemical binding]; other site
553174003671	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
553174003672	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
553174003673	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
553174003674	putative acyl-acceptor binding pocket; other site
553174003675	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
553174003676	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
553174003677	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
553174003678	Walker A/P-loop; other site
553174003679	ATP binding site [chemical binding]; other site
553174003680	Q-loop/lid; other site
553174003681	ABC transporter signature motif; other site
553174003682	Walker B; other site
553174003683	D-loop; other site
553174003684	H-loop/switch region; other site
553174003685	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
553174003686	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
553174003687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174003688	FeS/SAM binding site; other site
553174003689	TRAM domain; Region: TRAM; pfam01938
553174003690	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
553174003691	Peptidase family U32; Region: Peptidase_U32; pfam01136
553174003692	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
553174003693	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
553174003694	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
553174003695	active site
553174003696	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
553174003697	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
553174003698	ribonuclease R; Region: RNase_R; TIGR02063
553174003699	RNB domain; Region: RNB; pfam00773
553174003700	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
553174003701	RNA binding site [nucleotide binding]; other site
553174003702	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
553174003703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174003704	NAD(P) binding site [chemical binding]; other site
553174003705	active site
553174003706	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
553174003707	active site
553174003708	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
553174003709	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003710	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003711	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174003712	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
553174003713	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575
553174003714	putative ligand binding site [chemical binding]; other site
553174003715	putative catalytic site [active]
553174003716	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174003717	SusD family; Region: SusD; pfam07980
553174003718	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174003719	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003720	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003721	DnaA N-terminal domain; Region: DnaA_N; pfam11638
553174003722	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
553174003723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174003724	Walker A motif; other site
553174003725	ATP binding site [chemical binding]; other site
553174003726	Walker B motif; other site
553174003727	arginine finger; other site
553174003728	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
553174003729	DnaA box-binding interface [nucleotide binding]; other site
553174003730	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
553174003731	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
553174003732	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
553174003733	dimer interface [polypeptide binding]; other site
553174003734	active site
553174003735	metal binding site [ion binding]; metal-binding site
553174003736	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
553174003737	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
553174003738	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
553174003739	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
553174003740	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
553174003741	starch-binding site 2 [chemical binding]; other site
553174003742	Thiamine pyrophosphokinase; Region: TPK; cd07995
553174003743	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
553174003744	active site
553174003745	dimerization interface [polypeptide binding]; other site
553174003746	thiamine binding site [chemical binding]; other site
553174003747	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
553174003748	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174003749	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003750	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
553174003751	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174003752	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174003753	GLPGLI family protein; Region: GLPGLI; TIGR01200
553174003754	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
553174003755	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
553174003756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
553174003757	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
553174003758	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
553174003759	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
553174003760	Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379
553174003761	putative active site [active]
553174003762	putative metal binding site [ion binding]; other site
553174003763	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
553174003764	oligomeric interface; other site
553174003765	putative active site [active]
553174003766	homodimer interface [polypeptide binding]; other site
553174003767	Domain of unknown function (DUF377); Region: DUF377; pfam04041
553174003768	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
553174003769	active site
553174003770	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
553174003771	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
553174003772	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
553174003773	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
553174003774	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
553174003775	active site
553174003776	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174003777	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
553174003778	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
553174003779	active site
553174003780	substrate binding site [chemical binding]; other site
553174003781	ATP binding site [chemical binding]; other site
553174003782	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
553174003783	Phosphotransferase enzyme family; Region: APH; pfam01636
553174003784	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
553174003785	putative ligand binding site [chemical binding]; other site
553174003786	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
553174003787	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
553174003788	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
553174003789	DNA binding site [nucleotide binding]
553174003790	active site
553174003791	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
553174003792	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
553174003793	catalytic core [active]
553174003794	Tandemly repeated domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like; cl17916
553174003795	HipA-like N-terminal domain; Region: HipA_N; pfam07805
553174003796	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
553174003797	HipA-like C-terminal domain; Region: HipA_C; pfam07804
553174003798	HipA N-terminal domain; Region: couple_hipA; TIGR03071
553174003799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174003800	non-specific DNA binding site [nucleotide binding]; other site
553174003801	salt bridge; other site
553174003802	sequence-specific DNA binding site [nucleotide binding]; other site
553174003803	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
553174003804	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
553174003805	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
553174003806	Mg++ binding site [ion binding]; other site
553174003807	putative catalytic motif [active]
553174003808	substrate binding site [chemical binding]; other site
553174003809	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
553174003810	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174003811	active site
553174003812	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
553174003813	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
553174003814	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
553174003815	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
553174003816	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174003817	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174003818	active site
553174003819	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
553174003820	GDP-Fucose binding site [chemical binding]; other site
553174003821	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
553174003822	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
553174003823	SLBB domain; Region: SLBB; pfam10531
553174003824	SLBB domain; Region: SLBB; pfam10531
553174003825	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
553174003826	SLBB domain; Region: SLBB; pfam10531
553174003827	Bacterial sugar transferase; Region: Bac_transf; pfam02397
553174003828	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
553174003829	active site
553174003830	DNA polymerase IV; Validated; Region: PRK02406
553174003831	DNA binding site [nucleotide binding]
553174003832	pyruvate kinase; Provisional; Region: PRK05826
553174003833	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
553174003834	domain interfaces; other site
553174003835	active site
553174003836	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
553174003837	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
553174003838	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
553174003839	TPP-binding site [chemical binding]; other site
553174003840	dimer interface [polypeptide binding]; other site
553174003841	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
553174003842	PYR/PP interface [polypeptide binding]; other site
553174003843	dimer interface [polypeptide binding]; other site
553174003844	TPP binding site [chemical binding]; other site
553174003845	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
553174003846	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
553174003847	nudix motif; other site
553174003848	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
553174003849	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
553174003850	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
553174003851	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
553174003852	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
553174003853	L-fucose transporter; Provisional; Region: PRK10133; cl17665
553174003854	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
553174003855	active site
553174003856	catalytic residues [active]
553174003857	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
553174003858	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174003859	6-phosphofructokinase; Provisional; Region: PRK03202
553174003860	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
553174003861	active site
553174003862	ADP/pyrophosphate binding site [chemical binding]; other site
553174003863	dimerization interface [polypeptide binding]; other site
553174003864	allosteric effector site; other site
553174003865	fructose-1,6-bisphosphate binding site; other site
553174003866	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
553174003867	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
553174003868	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
553174003869	alpha subunit interaction interface [polypeptide binding]; other site
553174003870	Walker A motif; other site
553174003871	ATP binding site [chemical binding]; other site
553174003872	Walker B motif; other site
553174003873	inhibitor binding site; inhibition site
553174003874	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
553174003875	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
553174003876	gamma subunit interface [polypeptide binding]; other site
553174003877	LBP interface [polypeptide binding]; other site
553174003878	ATP synthase A chain; Region: ATP-synt_A; cl00413
553174003879	ATP synthase subunit C; Region: ATP-synt_C; cl00466
553174003880	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
553174003881	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
553174003882	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
553174003883	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
553174003884	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
553174003885	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
553174003886	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
553174003887	beta subunit interaction interface [polypeptide binding]; other site
553174003888	Walker A motif; other site
553174003889	ATP binding site [chemical binding]; other site
553174003890	Walker B motif; other site
553174003891	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
553174003892	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
553174003893	core domain interface [polypeptide binding]; other site
553174003894	delta subunit interface [polypeptide binding]; other site
553174003895	epsilon subunit interface [polypeptide binding]; other site
553174003896	Domain of unknown function (DUF389); Region: DUF389; pfam04087
553174003897	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
553174003898	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
553174003899	RNA binding site [nucleotide binding]; other site
553174003900	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
553174003901	RNA binding site [nucleotide binding]; other site
553174003902	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
553174003903	RNA binding site [nucleotide binding]; other site
553174003904	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
553174003905	RNA binding site [nucleotide binding]; other site
553174003906	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
553174003907	RNA binding site [nucleotide binding]; other site
553174003908	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
553174003909	Family of unknown function (DUF490); Region: DUF490; pfam04357
553174003910	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
553174003911	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
553174003912	E3 interaction surface; other site
553174003913	lipoyl attachment site [posttranslational modification]; other site
553174003914	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
553174003915	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
553174003916	FMN-binding domain; Region: FMN_bind; cl01081
553174003917	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
553174003918	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
553174003919	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
553174003920	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
553174003921	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
553174003922	catalytic loop [active]
553174003923	iron binding site [ion binding]; other site
553174003924	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
553174003925	FAD binding pocket [chemical binding]; other site
553174003926	FAD binding motif [chemical binding]; other site
553174003927	phosphate binding motif [ion binding]; other site
553174003928	beta-alpha-beta structure motif; other site
553174003929	NAD binding pocket [chemical binding]; other site
553174003930	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
553174003931	Abi-like protein; Region: Abi_2; cl01988
553174003932	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
553174003933	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174003934	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174003935	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174003936	active site
553174003937	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
553174003938	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
553174003939	active site
553174003940	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174003941	substrate binding site [chemical binding]; other site
553174003942	catalytic residues [active]
553174003943	dimer interface [polypeptide binding]; other site
553174003944	aspartate kinase III; Validated; Region: PRK09084
553174003945	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
553174003946	putative catalytic residues [active]
553174003947	nucleotide binding site [chemical binding]; other site
553174003948	aspartate binding site [chemical binding]; other site
553174003949	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
553174003950	dimer interface [polypeptide binding]; other site
553174003951	allosteric regulatory binding pocket; other site
553174003952	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
553174003953	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
553174003954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174003955	Walker A/P-loop; other site
553174003956	ATP binding site [chemical binding]; other site
553174003957	Q-loop/lid; other site
553174003958	ABC transporter signature motif; other site
553174003959	Walker B; other site
553174003960	D-loop; other site
553174003961	H-loop/switch region; other site
553174003962	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
553174003963	fumarate hydratase; Provisional; Region: PRK15389
553174003964	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
553174003965	Fumarase C-terminus; Region: Fumerase_C; pfam05683
553174003966	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174003967	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
553174003968	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174003969	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
553174003970	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
553174003971	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
553174003972	putative trimer interface [polypeptide binding]; other site
553174003973	putative CoA binding site [chemical binding]; other site
553174003974	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
553174003975	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
553174003976	HflX GTPase family; Region: HflX; cd01878
553174003977	G1 box; other site
553174003978	GTP/Mg2+ binding site [chemical binding]; other site
553174003979	Switch I region; other site
553174003980	G2 box; other site
553174003981	G3 box; other site
553174003982	Switch II region; other site
553174003983	G4 box; other site
553174003984	G5 box; other site
553174003985	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
553174003986	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
553174003987	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
553174003988	putative hydrolase; Provisional; Region: PRK02113
553174003989	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
553174003990	FAD binding domain; Region: FAD_binding_4; pfam01565
553174003991	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
553174003992	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
553174003993	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
553174003994	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
553174003995	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
553174003996	dimer interface [polypeptide binding]; other site
553174003997	motif 1; other site
553174003998	active site
553174003999	motif 2; other site
553174004000	motif 3; other site
553174004001	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
553174004002	active site
553174004003	catalytic site [active]
553174004004	substrate binding site [chemical binding]; other site
553174004005	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
553174004006	Part of AAA domain; Region: AAA_19; pfam13245
553174004007	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
553174004008	active site
553174004009	catalytic site [active]
553174004010	substrate binding site [chemical binding]; other site
553174004011	Family description; Region: UvrD_C_2; pfam13538
553174004012	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
553174004013	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
553174004014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174004015	FeS/SAM binding site; other site
553174004016	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
553174004017	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
553174004018	Probable Catalytic site; other site
553174004019	metal-binding site
553174004020	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
553174004021	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004022	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004023	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004024	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004025	Radical SAM superfamily; Region: Radical_SAM; pfam04055
553174004026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174004027	FeS/SAM binding site; other site
553174004028	MG2 domain; Region: A2M_N; pfam01835
553174004029	Alpha-2-macroglobulin family; Region: A2M; pfam00207
553174004030	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
553174004031	LytB protein; Region: LYTB; cl00507
553174004032	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
553174004033	L-fucose transporter; Provisional; Region: PRK10133; cl17665
553174004034	glucose/galactose transporter; Region: gluP; TIGR01272
553174004035	Secretin and TonB N terminus short domain; Region: STN; pfam07660
553174004036	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174004037	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004038	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
553174004039	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174004040	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174004041	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174004042	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
553174004043	active site
553174004044	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
553174004045	active site
553174004046	YtxH-like protein; Region: YtxH; pfam12732
553174004047	Sporulation related domain; Region: SPOR; pfam05036
553174004048	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
553174004049	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
553174004050	active site
553174004051	catalytic residues [active]
553174004052	metal binding site [ion binding]; metal-binding site
553174004053	TPR repeat; Region: TPR_11; pfam13414
553174004054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004055	binding surface
553174004056	TPR motif; other site
553174004057	TPR repeat; Region: TPR_11; pfam13414
553174004058	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
553174004059	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
553174004060	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
553174004061	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174004062	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
553174004063	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174004064	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174004065	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174004066	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174004067	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174004068	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
553174004069	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
553174004070	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
553174004071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
553174004072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
553174004073	dimer interface [polypeptide binding]; other site
553174004074	phosphorylation site [posttranslational modification]
553174004075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174004076	ATP binding site [chemical binding]; other site
553174004077	Mg2+ binding site [ion binding]; other site
553174004078	G-X-G motif; other site
553174004079	Response regulator receiver domain; Region: Response_reg; pfam00072
553174004080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
553174004081	active site
553174004082	phosphorylation site [posttranslational modification]
553174004083	intermolecular recognition site; other site
553174004084	dimerization interface [polypeptide binding]; other site
553174004085	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
553174004086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174004087	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
553174004088	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
553174004089	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
553174004090	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
553174004091	active site
553174004092	dimer interface [polypeptide binding]; other site
553174004093	motif 1; other site
553174004094	motif 2; other site
553174004095	motif 3; other site
553174004096	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
553174004097	anticodon binding site; other site
553174004098	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
553174004099	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
553174004100	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
553174004101	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
553174004102	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
553174004103	23S rRNA binding site [nucleotide binding]; other site
553174004104	L21 binding site [polypeptide binding]; other site
553174004105	L13 binding site [polypeptide binding]; other site
553174004106	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
553174004107	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
553174004108	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
553174004109	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
553174004110	RNA binding site [nucleotide binding]; other site
553174004111	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
553174004112	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
553174004113	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
553174004114	active site
553174004115	Zn binding site [ion binding]; other site
553174004116	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
553174004117	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
553174004118	ABC-ATPase subunit  interface; other site
553174004119	dimer interface [polypeptide binding]; other site
553174004120	putative PBP binding regions; other site
553174004121	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
553174004122	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
553174004123	intersubunit interface [polypeptide binding]; other site
553174004124	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
553174004125	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
553174004126	transmembrane helices; other site
553174004127	Domain of unknown function (DUF386); Region: DUF386; cl01047
553174004128	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
553174004129	Peptidase C10 family; Region: Peptidase_C10; pfam01640
553174004130	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174004131	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174004132	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174004133	Double zinc ribbon; Region: DZR; pfam12773
553174004134	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
553174004135	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
553174004136	Peptidase family U32; Region: Peptidase_U32; pfam01136
553174004137	metal binding site [ion binding]; metal-binding site
553174004138	Collagenase; Region: DUF3656; pfam12392
553174004139	Homoserine O-succinyltransferase; Region: HTS; pfam04204
553174004140	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
553174004141	proposed active site lysine [active]
553174004142	conserved cys residue [active]
553174004143	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
553174004144	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
553174004145	active site
553174004146	Zn binding site [ion binding]; other site
553174004147	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
553174004148	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174004149	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174004150	ABC transporter; Region: ABC_tran_2; pfam12848
553174004151	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174004152	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
553174004153	reactive center loop; other site
553174004154	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
553174004155	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
553174004156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174004157	HemN C-terminal domain; Region: HemN_C; pfam06969
553174004158	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
553174004159	elongation factor G; Reviewed; Region: PRK12740
553174004160	G1 box; other site
553174004161	putative GEF interaction site [polypeptide binding]; other site
553174004162	GTP/Mg2+ binding site [chemical binding]; other site
553174004163	Switch I region; other site
553174004164	G2 box; other site
553174004165	G3 box; other site
553174004166	Switch II region; other site
553174004167	G4 box; other site
553174004168	G5 box; other site
553174004169	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
553174004170	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
553174004171	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
553174004172	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174004173	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174004174	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
553174004175	Peptidase family C69; Region: Peptidase_C69; cl17793
553174004176	Peptidase family M23; Region: Peptidase_M23; pfam01551
553174004177	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
553174004178	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
553174004179	lipoprotein signal peptidase; Provisional; Region: PRK14788
553174004180	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
553174004181	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
553174004182	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174004183	active site
553174004184	HIGH motif; other site
553174004185	nucleotide binding site [chemical binding]; other site
553174004186	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174004187	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174004188	active site
553174004189	KMSKS motif; other site
553174004190	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
553174004191	tRNA binding surface [nucleotide binding]; other site
553174004192	anticodon binding site; other site
553174004193	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
553174004194	metal binding site 2 [ion binding]; metal-binding site
553174004195	putative DNA binding helix; other site
553174004196	metal binding site 1 [ion binding]; metal-binding site
553174004197	dimer interface [polypeptide binding]; other site
553174004198	structural Zn2+ binding site [ion binding]; other site
553174004199	Flavin Reductases; Region: FlaRed; cl00801
553174004200	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
553174004201	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
553174004202	catalytic core [active]
553174004203	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
553174004204	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
553174004205	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
553174004206	active site
553174004207	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
553174004208	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
553174004209	Predicted membrane protein [Function unknown]; Region: COG3059
553174004210	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
553174004211	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
553174004212	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
553174004213	Penicillinase repressor; Region: Pencillinase_R; pfam03965
553174004214	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
553174004215	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
553174004216	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174004217	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
553174004218	active site clefts [active]
553174004219	zinc binding site [ion binding]; other site
553174004220	dimer interface [polypeptide binding]; other site
553174004221	DKNYY family; Region: DKNYY; pfam13644
553174004222	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
553174004223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174004224	ABC transporter; Region: ABC_tran_2; pfam12848
553174004225	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174004226	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
553174004227	G1 box; other site
553174004228	GTP/Mg2+ binding site [chemical binding]; other site
553174004229	Switch I region; other site
553174004230	G2 box; other site
553174004231	G3 box; other site
553174004232	Switch II region; other site
553174004233	G4 box; other site
553174004234	G5 box; other site
553174004235	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
553174004236	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
553174004237	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
553174004238	Domain of unknown function (DUF4421); Region: DUF4421; pfam14391
553174004239	methionine sulfoxide reductase B; Provisional; Region: PRK00222
553174004240	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
553174004241	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
553174004242	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
553174004243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
553174004244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
553174004245	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
553174004246	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
553174004247	Substrate-binding site [chemical binding]; other site
553174004248	Substrate specificity [chemical binding]; other site
553174004249	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
553174004250	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
553174004251	Substrate-binding site [chemical binding]; other site
553174004252	Substrate specificity [chemical binding]; other site
553174004253	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
553174004254	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
553174004255	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
553174004256	DNA binding residues [nucleotide binding]
553174004257	dimerization interface [polypeptide binding]; other site
553174004258	OPT oligopeptide transporter protein; Region: OPT; pfam03169
553174004259	putative oligopeptide transporter, OPT family; Region: TIGR00733
553174004260	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
553174004261	homodimer interaction site [polypeptide binding]; other site
553174004262	cofactor binding site; other site
553174004263	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
553174004264	Protein of unknown function (DUF3256); Region: DUF3256; pfam11644
553174004265	nucleoside transporter; Region: 2A0110; TIGR00889
553174004266	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
553174004267	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
553174004268	RNA methyltransferase, RsmE family; Region: TIGR00046
553174004269	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
553174004270	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174004271	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174004272	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174004273	Cupin domain; Region: Cupin_2; pfam07883
553174004274	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
553174004275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174004276	D-galactonate transporter; Region: 2A0114; TIGR00893
553174004277	putative substrate translocation pore; other site
553174004278	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
553174004279	Class I aldolases; Region: Aldolase_Class_I; cl17187
553174004280	catalytic residue [active]
553174004281	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
553174004282	active site
553174004283	homodimer interface [polypeptide binding]; other site
553174004284	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
553174004285	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
553174004286	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
553174004287	putative catalytic site [active]
553174004288	putative metal binding site [ion binding]; other site
553174004289	putative phosphate binding site [ion binding]; other site
553174004290	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
553174004291	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
553174004292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174004293	trmE is a tRNA modification GTPase; Region: trmE; cd04164
553174004294	G1 box; other site
553174004295	Walker A/P-loop; other site
553174004296	GTP/Mg2+ binding site [chemical binding]; other site
553174004297	ATP binding site [chemical binding]; other site
553174004298	Switch I region; other site
553174004299	G2 box; other site
553174004300	Switch II region; other site
553174004301	G3 box; other site
553174004302	G4 box; other site
553174004303	G5 box; other site
553174004304	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
553174004305	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
553174004306	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
553174004307	Sporulation related domain; Region: SPOR; cl10051
553174004308	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
553174004309	phosphopeptide binding site; other site
553174004310	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
553174004311	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
553174004312	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
553174004313	dimer interface [polypeptide binding]; other site
553174004314	anticodon binding site; other site
553174004315	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
553174004316	homodimer interface [polypeptide binding]; other site
553174004317	motif 1; other site
553174004318	active site
553174004319	motif 2; other site
553174004320	GAD domain; Region: GAD; pfam02938
553174004321	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
553174004322	motif 3; other site
553174004323	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
553174004324	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
553174004325	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
553174004326	Substrate binding site; other site
553174004327	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
553174004328	SdiA-regulated; Region: SdiA-regulated; cd09971
553174004329	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
553174004330	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174004331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174004332	DNA binding residues [nucleotide binding]
553174004333	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
553174004334	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
553174004335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004336	TPR motif; other site
553174004337	binding surface
553174004338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004339	binding surface
553174004340	TPR motif; other site
553174004341	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
553174004342	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174004343	active site
553174004344	HIGH motif; other site
553174004345	nucleotide binding site [chemical binding]; other site
553174004346	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
553174004347	KMSKS motif; other site
553174004348	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
553174004349	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
553174004350	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
553174004351	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
553174004352	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
553174004353	minor groove reading motif; other site
553174004354	helix-hairpin-helix signature motif; other site
553174004355	substrate binding pocket [chemical binding]; other site
553174004356	active site
553174004357	TIGR02453 family protein; Region: TIGR02453
553174004358	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
553174004359	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
553174004360	active site
553174004361	HIGH motif; other site
553174004362	nucleotide binding site [chemical binding]; other site
553174004363	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
553174004364	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
553174004365	active site
553174004366	KMSKS motif; other site
553174004367	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
553174004368	tRNA binding surface [nucleotide binding]; other site
553174004369	anticodon binding site; other site
553174004370	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
553174004371	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
553174004372	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
553174004373	homodimer interface [polypeptide binding]; other site
553174004374	metal binding site [ion binding]; metal-binding site
553174004375	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
553174004376	homodimer interface [polypeptide binding]; other site
553174004377	active site
553174004378	putative chemical substrate binding site [chemical binding]; other site
553174004379	metal binding site [ion binding]; metal-binding site
553174004380	Lipocalin-like; Region: Lipocalin_3; pfam12702
553174004381	ribonuclease Z; Region: RNase_Z; TIGR02651
553174004382	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
553174004383	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
553174004384	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
553174004385	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
553174004386	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
553174004387	NTPase; Region: NTPase_1; cl17478
553174004388	AAA domain; Region: AAA_28; pfam13521
553174004389	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
553174004390	putative active site; other site
553174004391	putative metal binding residues [ion binding]; other site
553174004392	signature motif; other site
553174004393	putative triphosphate binding site [ion binding]; other site
553174004394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
553174004395	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174004396	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
553174004397	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
553174004398	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
553174004399	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
553174004400	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
553174004401	HSP70 interaction site [polypeptide binding]; other site
553174004402	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
553174004403	dimer interface [polypeptide binding]; other site
553174004404	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
553174004405	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
553174004406	active site
553174004407	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174004408	dimer interface [polypeptide binding]; other site
553174004409	catalytic residues [active]
553174004410	substrate binding site [chemical binding]; other site
553174004411	Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228
553174004412	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
553174004413	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
553174004414	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
553174004415	active site
553174004416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
553174004417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
553174004418	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
553174004419	N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854
553174004420	Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321
553174004421	active site
553174004422	catalytic site [active]
553174004423	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
553174004424	Imelysin; Region: Peptidase_M75; pfam09375
553174004425	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
553174004426	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
553174004427	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
553174004428	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
553174004429	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
553174004430	Walker A/P-loop; other site
553174004431	ATP binding site [chemical binding]; other site
553174004432	Q-loop/lid; other site
553174004433	ABC transporter signature motif; other site
553174004434	Walker B; other site
553174004435	D-loop; other site
553174004436	H-loop/switch region; other site
553174004437	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
553174004438	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
553174004439	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
553174004440	nucleotide binding region [chemical binding]; other site
553174004441	ATP-binding site [chemical binding]; other site
553174004442	SEC-C motif; Region: SEC-C; pfam02810
553174004443	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
553174004444	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
553174004445	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
553174004446	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
553174004447	Domain of unknown function DUF21; Region: DUF21; pfam01595
553174004448	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
553174004449	Transporter associated domain; Region: CorC_HlyC; smart01091
553174004450	SurA N-terminal domain; Region: SurA_N_2; pfam13623
553174004451	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
553174004452	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
553174004453	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174004454	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174004455	acyl-activating enzyme (AAE) consensus motif; other site
553174004456	AMP binding site [chemical binding]; other site
553174004457	active site
553174004458	CoA binding site [chemical binding]; other site
553174004459	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
553174004460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174004461	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
553174004462	active site
553174004463	motif I; other site
553174004464	motif II; other site
553174004465	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
553174004466	Methyltransferase domain; Region: Methyltransf_31; pfam13847
553174004467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174004468	S-adenosylmethionine binding site [chemical binding]; other site
553174004469	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
553174004470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
553174004471	active site
553174004472	phosphorylation site [posttranslational modification]
553174004473	intermolecular recognition site; other site
553174004474	dimerization interface [polypeptide binding]; other site
553174004475	LytTr DNA-binding domain; Region: LytTR; smart00850
553174004476	Histidine kinase; Region: His_kinase; pfam06580
553174004477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
553174004478	ATP binding site [chemical binding]; other site
553174004479	Mg2+ binding site [ion binding]; other site
553174004480	G-X-G motif; other site
553174004481	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
553174004482	Lumazine binding domain; Region: Lum_binding; pfam00677
553174004483	Lumazine binding domain; Region: Lum_binding; pfam00677
553174004484	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
553174004485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
553174004486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
553174004487	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
553174004488	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
553174004489	tetramer interface [polypeptide binding]; other site
553174004490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174004491	catalytic residue [active]
553174004492	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
553174004493	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
553174004494	tetramer interface [polypeptide binding]; other site
553174004495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174004496	catalytic residue [active]
553174004497	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
553174004498	lipoyl attachment site [posttranslational modification]; other site
553174004499	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
553174004500	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
553174004501	FMN-binding domain; Region: FMN_bind; pfam04205
553174004502	4Fe-4S binding domain; Region: Fer4_5; pfam12801
553174004503	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
553174004504	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
553174004505	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
553174004506	shikimate binding site; other site
553174004507	NAD(P) binding site [chemical binding]; other site
553174004508	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
553174004509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174004510	S-adenosylmethionine binding site [chemical binding]; other site
553174004511	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
553174004512	ATP binding site [chemical binding]; other site
553174004513	active site
553174004514	substrate binding site [chemical binding]; other site
553174004515	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
553174004516	PhoH-like protein; Region: PhoH; pfam02562
553174004517	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
553174004518	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
553174004519	imidazolonepropionase; Validated; Region: PRK09356
553174004520	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
553174004521	active site
553174004522	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
553174004523	active sites [active]
553174004524	tetramer interface [polypeptide binding]; other site
553174004525	urocanate hydratase; Provisional; Region: PRK05414
553174004526	glutamate formiminotransferase; Region: FtcD; TIGR02024
553174004527	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
553174004528	Formiminotransferase domain; Region: FTCD; pfam02971
553174004529	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
553174004530	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
553174004531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174004532	NAD(P) binding site [chemical binding]; other site
553174004533	active site
553174004534	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
553174004535	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174004536	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
553174004537	active site
553174004538	dimer interface [polypeptide binding]; other site
553174004539	peptide chain release factor 1; Validated; Region: prfA; PRK00591
553174004540	This domain is found in peptide chain release factors; Region: PCRF; smart00937
553174004541	RF-1 domain; Region: RF-1; pfam00472
553174004542	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
553174004543	dimerization interface [polypeptide binding]; other site
553174004544	ATP binding site [chemical binding]; other site
553174004545	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
553174004546	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
553174004547	Ligand binding site; other site
553174004548	oligomer interface; other site
553174004549	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
553174004550	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
553174004551	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
553174004552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174004553	active site
553174004554	motif I; other site
553174004555	motif II; other site
553174004556	Maf-like protein; Region: Maf; pfam02545
553174004557	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
553174004558	active site
553174004559	dimer interface [polypeptide binding]; other site
553174004560	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
553174004561	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
553174004562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174004563	motif II; other site
553174004564	YceG-like family; Region: YceG; pfam02618
553174004565	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
553174004566	dimerization interface [polypeptide binding]; other site
553174004567	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
553174004568	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
553174004569	active site
553174004570	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
553174004571	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
553174004572	NAD(P) binding site [chemical binding]; other site
553174004573	homotetramer interface [polypeptide binding]; other site
553174004574	homodimer interface [polypeptide binding]; other site
553174004575	active site
553174004576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
553174004577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
553174004578	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
553174004579	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
553174004580	NAD binding site [chemical binding]; other site
553174004581	homodimer interface [polypeptide binding]; other site
553174004582	active site
553174004583	substrate binding site [chemical binding]; other site
553174004584	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
553174004585	transcription termination factor Rho; Provisional; Region: PRK12608
553174004586	RNA binding site [nucleotide binding]; other site
553174004587	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
553174004588	multimer interface [polypeptide binding]; other site
553174004589	Walker A motif; other site
553174004590	ATP binding site [chemical binding]; other site
553174004591	Walker B motif; other site
553174004592	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
553174004593	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
553174004594	HD domain; Region: HD_4; pfam13328
553174004595	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
553174004596	synthetase active site [active]
553174004597	NTP binding site [chemical binding]; other site
553174004598	metal binding site [ion binding]; metal-binding site
553174004599	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
553174004600	ACT domain; Region: ACT_4; pfam13291
553174004601	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
553174004602	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
553174004603	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
553174004604	active site
553174004605	serine O-acetyltransferase; Region: cysE; TIGR01172
553174004606	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
553174004607	trimer interface [polypeptide binding]; other site
553174004608	active site
553174004609	substrate binding site [chemical binding]; other site
553174004610	CoA binding site [chemical binding]; other site
553174004611	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
553174004612	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
553174004613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
553174004614	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
553174004615	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
553174004616	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
553174004617	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
553174004618	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
553174004619	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
553174004620	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
553174004621	Predicted membrane protein [Function unknown]; Region: COG1238
553174004622	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
553174004623	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
553174004624	Potassium binding sites [ion binding]; other site
553174004625	Cesium cation binding sites [ion binding]; other site
553174004626	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
553174004627	active site
553174004628	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
553174004629	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
553174004630	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
553174004631	active site
553174004632	catalytic triad [active]
553174004633	oxyanion hole [active]
553174004634	replicative DNA helicase; Region: DnaB; TIGR00665
553174004635	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
553174004636	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
553174004637	Walker A motif; other site
553174004638	ATP binding site [chemical binding]; other site
553174004639	Walker B motif; other site
553174004640	DNA binding loops [nucleotide binding]
553174004641	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
553174004642	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
553174004643	Part of AAA domain; Region: AAA_19; pfam13245
553174004644	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
553174004645	Family description; Region: UvrD_C_2; pfam13538
553174004646	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
553174004647	probable DNA repair protein; Region: TIGR03623
553174004648	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
553174004649	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
553174004650	Part of AAA domain; Region: AAA_19; pfam13245
553174004651	Family description; Region: UvrD_C_2; pfam13538
553174004652	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
553174004653	Transglycosylase; Region: Transgly; cl17702
553174004654	heat shock protein 90; Provisional; Region: PRK05218
553174004655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174004656	ATP binding site [chemical binding]; other site
553174004657	Mg2+ binding site [ion binding]; other site
553174004658	G-X-G motif; other site
553174004659	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
553174004660	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
553174004661	metal binding site [ion binding]; metal-binding site
553174004662	dimer interface [polypeptide binding]; other site
553174004663	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
553174004664	Predicted peptidase [General function prediction only]; Region: COG4099
553174004665	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
553174004666	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
553174004667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174004668	FeS/SAM binding site; other site
553174004669	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174004670	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174004671	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
553174004672	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
553174004673	ribosomal protein L33; Region: rpl33; CHL00104
553174004674	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
553174004675	Competence-damaged protein; Region: CinA; pfam02464
553174004676	UGMP family protein; Validated; Region: PRK09604
553174004677	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
553174004678	methionine aminopeptidase; Provisional; Region: PRK12318
553174004679	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
553174004680	active site
553174004681	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
553174004682	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
553174004683	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
553174004684	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
553174004685	substrate binding pocket [chemical binding]; other site
553174004686	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
553174004687	B12 binding site [chemical binding]; other site
553174004688	cobalt ligand [ion binding]; other site
553174004689	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
553174004690	SmpB-tmRNA interface; other site
553174004691	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
553174004692	Rubredoxin [Energy production and conversion]; Region: COG1773
553174004693	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
553174004694	iron binding site [ion binding]; other site
553174004695	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
553174004696	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
553174004697	Surface antigen; Region: Bac_surface_Ag; pfam01103
553174004698	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
553174004699	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
553174004700	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
553174004701	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
553174004702	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174004703	homodimer interface [polypeptide binding]; other site
553174004704	catalytic residue [active]
553174004705	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
553174004706	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174004707	catalytic residue [active]
553174004708	aspartate aminotransferase; Provisional; Region: PRK07568
553174004709	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
553174004710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174004711	homodimer interface [polypeptide binding]; other site
553174004712	catalytic residue [active]
553174004713	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
553174004714	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
553174004715	FtsX-like permease family; Region: FtsX; pfam02687
553174004716	YolD-like protein; Region: YolD; pfam08863
553174004717	DNA polymerase IV; Reviewed; Region: PRK03103
553174004718	Y-family of DNA polymerases; Region: PolY; cl12025
553174004719	active site
553174004720	DNA binding site [nucleotide binding]
553174004721	GTP-binding protein LepA; Provisional; Region: PRK05433
553174004722	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
553174004723	G1 box; other site
553174004724	putative GEF interaction site [polypeptide binding]; other site
553174004725	GTP/Mg2+ binding site [chemical binding]; other site
553174004726	Switch I region; other site
553174004727	G2 box; other site
553174004728	G3 box; other site
553174004729	Switch II region; other site
553174004730	G4 box; other site
553174004731	G5 box; other site
553174004732	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
553174004733	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
553174004734	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
553174004735	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
553174004736	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
553174004737	ligand binding site [chemical binding]; other site
553174004738	flexible hinge region; other site
553174004739	MG2 domain; Region: A2M_N; pfam01835
553174004740	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174004741	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174004742	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174004743	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
553174004744	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
553174004745	MutS domain III; Region: MutS_III; pfam05192
553174004746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174004747	Walker A/P-loop; other site
553174004748	ATP binding site [chemical binding]; other site
553174004749	Q-loop/lid; other site
553174004750	ABC transporter signature motif; other site
553174004751	Walker B; other site
553174004752	D-loop; other site
553174004753	H-loop/switch region; other site
553174004754	Smr domain; Region: Smr; pfam01713
553174004755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004756	TPR motif; other site
553174004757	binding surface
553174004758	Tetratricopeptide repeat; Region: TPR_16; pfam13432
553174004759	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
553174004760	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
553174004761	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
553174004762	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174004763	ligand binding site [chemical binding]; other site
553174004764	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
553174004765	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
553174004766	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
553174004767	thymidylate synthase; Reviewed; Region: thyA; PRK01827
553174004768	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
553174004769	dimerization interface [polypeptide binding]; other site
553174004770	active site
553174004771	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
553174004772	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
553174004773	folate binding site [chemical binding]; other site
553174004774	NADP+ binding site [chemical binding]; other site
553174004775	Surface antigen; Region: Bac_surface_Ag; pfam01103
553174004776	Family of unknown function (DUF490); Region: DUF490; pfam04357
553174004777	Uncharacterized conserved protein [Function unknown]; Region: COG1739
553174004778	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
553174004779	Uncharacterized conserved protein [Function unknown]; Region: COG4198
553174004780	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
553174004781	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
553174004782	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
553174004783	putative ligand binding site [chemical binding]; other site
553174004784	putative NAD binding site [chemical binding]; other site
553174004785	putative catalytic site [active]
553174004786	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
553174004787	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
553174004788	catalytic residue [active]
553174004789	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
553174004790	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
553174004791	ATP binding site [chemical binding]; other site
553174004792	putative Mg++ binding site [ion binding]; other site
553174004793	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174004794	nucleotide binding region [chemical binding]; other site
553174004795	ATP-binding site [chemical binding]; other site
553174004796	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
553174004797	RNA binding site [nucleotide binding]; other site
553174004798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004799	binding surface
553174004800	TPR motif; other site
553174004801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004802	TPR motif; other site
553174004803	TPR repeat; Region: TPR_11; pfam13414
553174004804	binding surface
553174004805	DNA gyrase subunit A; Validated; Region: PRK05560
553174004806	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
553174004807	CAP-like domain; other site
553174004808	active site
553174004809	primary dimer interface [polypeptide binding]; other site
553174004810	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004811	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004812	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004813	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004814	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004815	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
553174004816	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
553174004817	NAD synthetase; Reviewed; Region: nadE; PRK02628
553174004818	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
553174004819	multimer interface [polypeptide binding]; other site
553174004820	active site
553174004821	catalytic triad [active]
553174004822	protein interface 1 [polypeptide binding]; other site
553174004823	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
553174004824	homodimer interface [polypeptide binding]; other site
553174004825	NAD binding pocket [chemical binding]; other site
553174004826	ATP binding pocket [chemical binding]; other site
553174004827	Mg binding site [ion binding]; other site
553174004828	active-site loop [active]
553174004829	Domain of unknown function (DUF2027); Region: DUF2027; pfam09640
553174004830	Smr domain; Region: Smr; pfam01713
553174004831	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
553174004832	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
553174004833	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
553174004834	active site
553174004835	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
553174004836	Oxygen tolerance; Region: BatD; pfam13584
553174004837	TPR repeat; Region: TPR_11; pfam13414
553174004838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004839	binding surface
553174004840	TPR motif; other site
553174004841	Bacterial SH3 domain homologues; Region: SH3b; smart00287
553174004842	TPR repeat; Region: TPR_11; pfam13414
553174004843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174004844	binding surface
553174004845	TPR motif; other site
553174004846	TPR repeat; Region: TPR_11; pfam13414
553174004847	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
553174004848	metal ion-dependent adhesion site (MIDAS); other site
553174004849	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
553174004850	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
553174004851	metal ion-dependent adhesion site (MIDAS); other site
553174004852	Oxygen tolerance; Region: BatD; pfam13584
553174004853	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
553174004854	Protein of unknown function DUF58; Region: DUF58; pfam01882
553174004855	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
553174004856	metal ion-dependent adhesion site (MIDAS); other site
553174004857	MoxR-like ATPases [General function prediction only]; Region: COG0714
553174004858	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
553174004859	ATP binding site [chemical binding]; other site
553174004860	Walker A motif; other site
553174004861	Walker B motif; other site
553174004862	arginine finger; other site
553174004863	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
553174004864	IHF dimer interface [polypeptide binding]; other site
553174004865	IHF - DNA interface [nucleotide binding]; other site
553174004866	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
553174004867	IHF - DNA interface [nucleotide binding]; other site
553174004868	IHF dimer interface [polypeptide binding]; other site
553174004869	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
553174004870	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
553174004871	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174004872	FeS/SAM binding site; other site
553174004873	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
553174004874	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
553174004875	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
553174004876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174004877	Major Facilitator Superfamily; Region: MFS_1; pfam07690
553174004878	putative substrate translocation pore; other site
553174004879	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
553174004880	oligomerization interface [polypeptide binding]; other site
553174004881	active site
553174004882	metal binding site [ion binding]; metal-binding site
553174004883	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
553174004884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174004885	motif II; other site
553174004886	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
553174004887	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
553174004888	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
553174004889	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
553174004890	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
553174004891	active site
553174004892	putative DNA-binding cleft [nucleotide binding]; other site
553174004893	dimer interface [polypeptide binding]; other site
553174004894	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
553174004895	Transglycosylase; Region: Transgly; pfam00912
553174004896	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
553174004897	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
553174004898	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
553174004899	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
553174004900	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174004901	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
553174004902	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
553174004903	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
553174004904	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174004905	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
553174004906	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
553174004907	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
553174004908	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
553174004909	active site
553174004910	metal binding site [ion binding]; metal-binding site
553174004911	homotetramer interface [polypeptide binding]; other site
553174004912	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
553174004913	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
553174004914	NAD binding site [chemical binding]; other site
553174004915	substrate binding site [chemical binding]; other site
553174004916	homodimer interface [polypeptide binding]; other site
553174004917	active site
553174004918	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
553174004919	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
553174004920	ATP-grasp domain; Region: ATP-grasp; pfam02222
553174004921	WxcM-like, C-terminal; Region: FdtA; pfam05523
553174004922	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
553174004923	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
553174004924	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
553174004925	inhibitor-cofactor binding pocket; inhibition site
553174004926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
553174004927	catalytic residue [active]
553174004928	Uncharacterized conserved protein [Function unknown]; Region: COG3538
553174004929	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
553174004930	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
553174004931	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
553174004932	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
553174004933	active site
553174004934	oxyanion hole [active]
553174004935	catalytic triad [active]
553174004936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
553174004937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
553174004938	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
553174004939	Malic enzyme, N-terminal domain; Region: malic; pfam00390
553174004940	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
553174004941	putative NAD(P) binding site [chemical binding]; other site
553174004942	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
553174004943	Peptidase family M49; Region: Peptidase_M49; pfam03571
553174004944	Helix-turn-helix domain; Region: HTH_18; pfam12833
553174004945	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
553174004946	hybrid cluster protein; Provisional; Region: PRK05290
553174004947	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174004948	ACS interaction site; other site
553174004949	CODH interaction site; other site
553174004950	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
553174004951	hybrid metal cluster; other site
553174004952	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
553174004953	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
553174004954	NADP-binding site; other site
553174004955	homotetramer interface [polypeptide binding]; other site
553174004956	substrate binding site [chemical binding]; other site
553174004957	homodimer interface [polypeptide binding]; other site
553174004958	active site
553174004959	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
553174004960	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
553174004961	NADP binding site [chemical binding]; other site
553174004962	active site
553174004963	putative substrate binding site [chemical binding]; other site
553174004964	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
553174004965	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
553174004966	Protein of unknown function (DUF328); Region: DUF328; pfam03883
553174004967	acyl-CoA synthetase; Validated; Region: PRK06145
553174004968	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
553174004969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174004970	S-adenosylmethionine binding site [chemical binding]; other site
553174004971	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
553174004972	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
553174004973	active site
553174004974	ADP/pyrophosphate binding site [chemical binding]; other site
553174004975	dimerization interface [polypeptide binding]; other site
553174004976	allosteric effector site; other site
553174004977	fructose-1,6-bisphosphate binding site; other site
553174004978	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
553174004979	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
553174004980	putative acyl-acceptor binding pocket; other site
553174004981	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
553174004982	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
553174004983	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
553174004984	Interdomain contacts; other site
553174004985	Cytokine receptor motif; other site
553174004986	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
553174004987	hypothetical protein; Provisional; Region: PRK00955
553174004988	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
553174004989	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
553174004990	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
553174004991	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
553174004992	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
553174004993	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
553174004994	carboxyltransferase (CT) interaction site; other site
553174004995	biotinylation site [posttranslational modification]; other site
553174004996	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
553174004997	tetramerization interface [polypeptide binding]; other site
553174004998	active site
553174004999	Pantoate-beta-alanine ligase; Region: PanC; cd00560
553174005000	pantoate--beta-alanine ligase; Region: panC; TIGR00018
553174005001	active site
553174005002	ATP-binding site [chemical binding]; other site
553174005003	pantoate-binding site; other site
553174005004	HXXH motif; other site
553174005005	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
553174005006	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
553174005007	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
553174005008	Clp amino terminal domain; Region: Clp_N; pfam02861
553174005009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174005010	Walker A motif; other site
553174005011	ATP binding site [chemical binding]; other site
553174005012	Walker B motif; other site
553174005013	arginine finger; other site
553174005014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174005015	Walker A motif; other site
553174005016	ATP binding site [chemical binding]; other site
553174005017	Walker B motif; other site
553174005018	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
553174005019	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
553174005020	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
553174005021	active site
553174005022	substrate binding site [chemical binding]; other site
553174005023	metal binding site [ion binding]; metal-binding site
553174005024	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
553174005025	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005026	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005027	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
553174005028	active site
553174005029	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
553174005030	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
553174005031	active site
553174005032	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
553174005033	EamA-like transporter family; Region: EamA; pfam00892
553174005034	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
553174005035	active site
553174005036	catalytic triad [active]
553174005037	oxyanion hole [active]
553174005038	Sodium Bile acid symporter family; Region: SBF; cl17470
553174005039	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
553174005040	catalytic residues [active]
553174005041	dimer interface [polypeptide binding]; other site
553174005042	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
553174005043	Na binding site [ion binding]; other site
553174005044	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
553174005045	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
553174005046	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
553174005047	catalytic residue [active]
553174005048	pantothenate kinase; Provisional; Region: PRK13317
553174005049	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
553174005050	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
553174005051	IHF - DNA interface [nucleotide binding]; other site
553174005052	IHF dimer interface [polypeptide binding]; other site
553174005053	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
553174005054	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
553174005055	homodimer interface [polypeptide binding]; other site
553174005056	oligonucleotide binding site [chemical binding]; other site
553174005057	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
553174005058	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
553174005059	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
553174005060	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
553174005061	active site
553174005062	catalytic site [active]
553174005063	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
553174005064	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
553174005065	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
553174005066	CrcB-like protein; Region: CRCB; cl09114
553174005067	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005068	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
553174005069	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
553174005070	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
553174005071	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174005072	motif II; other site
553174005073	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
553174005074	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
553174005075	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174005076	active site
553174005077	YARHG domain; Region: YARHG; pfam13308
553174005078	Protein of unknown function (DUF3160); Region: DUF3160; pfam11369
553174005079	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
553174005080	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
553174005081	putative active site [active]
553174005082	putative metal binding site [ion binding]; other site
553174005083	A new structural DNA glycosylase; Region: AlkD_like; cd06561
553174005084	active site
553174005085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174005086	binding surface
553174005087	TPR motif; other site
553174005088	TPR repeat; Region: TPR_11; pfam13414
553174005089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
553174005090	binding surface
553174005091	Tetratricopeptide repeat; Region: TPR_16; pfam13432
553174005092	TPR motif; other site
553174005093	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
553174005094	DNA repair protein RadA; Provisional; Region: PRK11823
553174005095	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
553174005096	Walker A motif/ATP binding site; other site
553174005097	ATP binding site [chemical binding]; other site
553174005098	Walker B motif; other site
553174005099	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
553174005100	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
553174005101	homopentamer interface [polypeptide binding]; other site
553174005102	active site
553174005103	Tetratricopeptide repeat; Region: TPR_12; pfam13424
553174005104	recombination protein F; Reviewed; Region: recF; PRK00064
553174005105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174005106	Walker A/P-loop; other site
553174005107	ATP binding site [chemical binding]; other site
553174005108	Q-loop/lid; other site
553174005109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174005110	ABC transporter signature motif; other site
553174005111	Walker B; other site
553174005112	D-loop; other site
553174005113	H-loop/switch region; other site
553174005114	Protein of unknown function (DUF721); Region: DUF721; pfam05258
553174005115	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
553174005116	dihydrodipicolinate synthase; Region: dapA; TIGR00674
553174005117	dimer interface [polypeptide binding]; other site
553174005118	active site
553174005119	catalytic residue [active]
553174005120	EamA-like transporter family; Region: EamA; cl17759
553174005121	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
553174005122	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
553174005123	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
553174005124	dimerization interface 3.5A [polypeptide binding]; other site
553174005125	active site
553174005126	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
553174005127	Competence protein; Region: Competence; pfam03772
553174005128	Flavodoxin domain; Region: Flavodoxin_5; cl17428
553174005129	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174005130	Ferredoxin [Energy production and conversion]; Region: COG1146
553174005131	M6 family metalloprotease domain; Region: M6dom_TIGR03296
553174005132	AMP-binding enzyme; Region: AMP-binding; pfam00501
553174005133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
553174005134	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
553174005135	acyl-activating enzyme (AAE) consensus motif; other site
553174005136	acyl-activating enzyme (AAE) consensus motif; other site
553174005137	putative AMP binding site [chemical binding]; other site
553174005138	putative active site [active]
553174005139	putative CoA binding site [chemical binding]; other site
553174005140	hypothetical protein; Provisional; Region: PRK12378
553174005141	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
553174005142	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
553174005143	putative tRNA-binding site [nucleotide binding]; other site
553174005144	B3/4 domain; Region: B3_4; pfam03483
553174005145	tRNA synthetase B5 domain; Region: B5; smart00874
553174005146	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
553174005147	dimer interface [polypeptide binding]; other site
553174005148	motif 1; other site
553174005149	motif 3; other site
553174005150	motif 2; other site
553174005151	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
553174005152	Predicted metalloprotease [General function prediction only]; Region: COG2321
553174005153	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
553174005154	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
553174005155	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
553174005156	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
553174005157	putative catalytic residues [active]
553174005158	putative nucleotide binding site [chemical binding]; other site
553174005159	putative aspartate binding site [chemical binding]; other site
553174005160	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
553174005161	dimer interface [polypeptide binding]; other site
553174005162	putative threonine allosteric regulatory site; other site
553174005163	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
553174005164	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
553174005165	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
553174005166	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
553174005167	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
553174005168	dimerization interface [polypeptide binding]; other site
553174005169	active site
553174005170	quinolinate synthetase; Provisional; Region: PRK09375
553174005171	L-aspartate oxidase; Provisional; Region: PRK09077
553174005172	L-aspartate oxidase; Provisional; Region: PRK06175
553174005173	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
553174005174	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
553174005175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
553174005176	active site
553174005177	phosphorylation site [posttranslational modification]
553174005178	intermolecular recognition site; other site
553174005179	dimerization interface [polypeptide binding]; other site
553174005180	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
553174005181	DNA binding site [nucleotide binding]
553174005182	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
553174005183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
553174005184	dimer interface [polypeptide binding]; other site
553174005185	phosphorylation site [posttranslational modification]
553174005186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174005187	ATP binding site [chemical binding]; other site
553174005188	Mg2+ binding site [ion binding]; other site
553174005189	G-X-G motif; other site
553174005190	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005191	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005192	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
553174005193	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
553174005194	Ligand Binding Site [chemical binding]; other site
553174005195	TilS substrate C-terminal domain; Region: TilS_C; smart00977
553174005196	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
553174005197	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
553174005198	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
553174005199	putative RNA binding site [nucleotide binding]; other site
553174005200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174005201	S-adenosylmethionine binding site [chemical binding]; other site
553174005202	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
553174005203	catalytic site [active]
553174005204	putative active site [active]
553174005205	putative substrate binding site [chemical binding]; other site
553174005206	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
553174005207	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
553174005208	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
553174005209	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
553174005210	seryl-tRNA synthetase; Provisional; Region: PRK05431
553174005211	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
553174005212	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
553174005213	dimer interface [polypeptide binding]; other site
553174005214	active site
553174005215	motif 1; other site
553174005216	motif 2; other site
553174005217	motif 3; other site
553174005218	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
553174005219	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
553174005220	FAD binding pocket [chemical binding]; other site
553174005221	FAD binding motif [chemical binding]; other site
553174005222	phosphate binding motif [ion binding]; other site
553174005223	beta-alpha-beta structure motif; other site
553174005224	NAD binding pocket [chemical binding]; other site
553174005225	Iron coordination center [ion binding]; other site
553174005226	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
553174005227	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
553174005228	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
553174005229	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
553174005230	Ligand Binding Site [chemical binding]; other site
553174005231	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
553174005232	Phosphoglycerate kinase; Region: PGK; pfam00162
553174005233	substrate binding site [chemical binding]; other site
553174005234	hinge regions; other site
553174005235	ADP binding site [chemical binding]; other site
553174005236	catalytic site [active]
553174005237	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
553174005238	putative active site [active]
553174005239	LytTr DNA-binding domain; Region: LytTR; smart00850
553174005240	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
553174005241	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
553174005242	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
553174005243	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174005244	muropeptide transporter; Reviewed; Region: ampG; PRK11902
553174005245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174005246	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
553174005247	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
553174005248	active site
553174005249	trimer interface [polypeptide binding]; other site
553174005250	allosteric site; other site
553174005251	active site lid [active]
553174005252	hexamer (dimer of trimers) interface [polypeptide binding]; other site
553174005253	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
553174005254	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
553174005255	active site
553174005256	trimer interface [polypeptide binding]; other site
553174005257	allosteric site; other site
553174005258	active site lid [active]
553174005259	hexamer (dimer of trimers) interface [polypeptide binding]; other site
553174005260	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
553174005261	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
553174005262	catalytic site [active]
553174005263	BNR repeat-like domain; Region: BNR_2; pfam13088
553174005264	Asp-box motif; other site
553174005265	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
553174005266	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
553174005267	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
553174005268	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174005269	Secretin and TonB N terminus short domain; Region: STN; pfam07660
553174005270	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005271	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005272	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174005273	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005274	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
553174005275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174005276	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174005277	DNA binding residues [nucleotide binding]
553174005278	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174005279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174005280	Carbohydrate phosphorylase; Region: Phosphorylase; pfam00343
553174005281	FecR protein; Region: FecR; pfam04773
553174005282	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
553174005283	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
553174005284	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
553174005285	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
553174005286	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
553174005287	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
553174005288	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
553174005289	RNA binding surface [nucleotide binding]; other site
553174005290	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
553174005291	active site
553174005292	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
553174005293	Zn2+ binding site [ion binding]; other site
553174005294	Mg2+ binding site [ion binding]; other site
553174005295	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
553174005296	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
553174005297	active site
553174005298	metal binding site [ion binding]; metal-binding site
553174005299	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
553174005300	E3 interaction surface; other site
553174005301	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
553174005302	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
553174005303	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
553174005304	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
553174005305	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
553174005306	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
553174005307	putative DNA binding site [nucleotide binding]; other site
553174005308	putative Zn2+ binding site [ion binding]; other site
553174005309	AsnC family; Region: AsnC_trans_reg; pfam01037
553174005310	Major Facilitator Superfamily; Region: MFS_1; pfam07690
553174005311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174005312	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
553174005313	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
553174005314	membrane protein insertase; Provisional; Region: PRK01318
553174005315	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
553174005316	CTP synthetase; Validated; Region: pyrG; PRK05380
553174005317	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
553174005318	Catalytic site [active]
553174005319	active site
553174005320	UTP binding site [chemical binding]; other site
553174005321	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
553174005322	active site
553174005323	putative oxyanion hole; other site
553174005324	catalytic triad [active]
553174005325	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
553174005326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
553174005327	NAD(P) binding site [chemical binding]; other site
553174005328	active site
553174005329	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
553174005330	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005331	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005332	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005333	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005334	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
553174005335	active site
553174005336	catalytic residues [active]
553174005337	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005338	HsdM N-terminal domain; Region: HsdM_N; pfam12161
553174005339	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
553174005340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174005341	S-adenosylmethionine binding site [chemical binding]; other site
553174005342	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174005343	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174005344	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174005345	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
553174005346	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
553174005347	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
553174005348	ATP binding site [chemical binding]; other site
553174005349	putative Mg++ binding site [ion binding]; other site
553174005350	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
553174005351	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
553174005352	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
553174005353	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
553174005354	active site
553174005355	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
553174005356	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174005357	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005358	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005359	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174005360	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174005361	Domain of unknown function DUF59; Region: DUF59; cl00941
553174005362	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
553174005363	Walker A motif; other site
553174005364	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174005366	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174005367	Carbohydrate phosphorylase; Region: Phosphorylase; pfam00343
553174005368	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
553174005369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
553174005370	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174005371	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
553174005372	Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174
553174005373	PLD-like domain; Region: PLDc_2; pfam13091
553174005374	putative active site [active]
553174005375	catalytic site [active]
553174005376	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
553174005377	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
553174005378	active site
553174005379	metal binding site [ion binding]; metal-binding site
553174005380	interdomain interaction site; other site
553174005381	AAA domain; Region: AAA_25; pfam13481
553174005382	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
553174005383	Walker A motif; other site
553174005384	ATP binding site [chemical binding]; other site
553174005385	Walker B motif; other site
553174005386	Helix-turn-helix domain; Region: HTH_17; cl17695
553174005387	Abi-like protein; Region: Abi_2; pfam07751
553174005388	helicase superfamily c-terminal domain; Region: HELICc; smart00490
553174005389	ATP-binding site [chemical binding]; other site
553174005390	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005391	active site
553174005392	DNA binding site [nucleotide binding]
553174005393	Int/Topo IB signature motif; other site
553174005394	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005395	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
553174005396	active site
553174005397	DNA binding site [nucleotide binding]
553174005398	Int/Topo IB signature motif; other site
553174005399	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
553174005400	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174005401	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174005402	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
553174005403	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
553174005404	Family description; Region: VCBS; pfam13517
553174005405	Family description; Region: VCBS; pfam13517
553174005406	Family description; Region: VCBS; pfam13517
553174005407	Family description; Region: VCBS; pfam13517
553174005408	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
553174005409	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
553174005410	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005411	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
553174005412	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005413	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
553174005414	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005415	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
553174005416	Family description; Region: VCBS; pfam13517
553174005417	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
553174005418	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
553174005419	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
553174005420	RHS Repeat; Region: RHS_repeat; pfam05593
553174005421	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005422	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
553174005424	binding surface
553174005425	TPR motif; other site
553174005426	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
553174005427	RHS Repeat; Region: RHS_repeat; cl11982
553174005428	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005429	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174005430	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
553174005431	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
553174005432	putative peroxiredoxin; Provisional; Region: PRK13190
553174005433	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005434	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005435	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
553174005436	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174005437	Helix-turn-helix domain; Region: HTH_17; pfam12728
553174005438	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
553174005439	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005440	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
553174005441	active site
553174005442	DNA binding site [nucleotide binding]
553174005443	Int/Topo IB signature motif; other site
553174005444	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005445	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
553174005446	active site
553174005447	DNA binding site [nucleotide binding]
553174005448	Int/Topo IB signature motif; other site
553174005449	Methyltransferase domain; Region: Methyltransf_26; pfam13659
553174005450	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
553174005451	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
553174005452	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
553174005453	DEAD-like helicases superfamily; Region: DEXDc; smart00487
553174005454	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
553174005455	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
553174005456	DNA topoisomerase III; Provisional; Region: PRK07726
553174005457	active site
553174005458	putative interdomain interaction site [polypeptide binding]; other site
553174005459	putative metal-binding site [ion binding]; other site
553174005460	putative nucleotide binding site [chemical binding]; other site
553174005461	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
553174005462	domain I; other site
553174005463	DNA binding groove [nucleotide binding]
553174005464	phosphate binding site [ion binding]; other site
553174005465	domain II; other site
553174005466	domain III; other site
553174005467	nucleotide binding site [chemical binding]; other site
553174005468	catalytic site [active]
553174005469	domain IV; other site
553174005470	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
553174005471	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
553174005472	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
553174005473	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
553174005474	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
553174005475	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
553174005476	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
553174005477	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
553174005478	catalytic residue [active]
553174005479	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
553174005480	Peptidase C10 family; Region: Peptidase_C10; pfam01640
553174005481	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
553174005482	B12 binding site [chemical binding]; other site
553174005483	Radical SAM superfamily; Region: Radical_SAM; pfam04055
553174005484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174005485	FeS/SAM binding site; other site
553174005486	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005487	YWFCY protein; Region: YWFCY; pfam14293
553174005488	AAA-like domain; Region: AAA_10; pfam12846
553174005489	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
553174005490	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
553174005491	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
553174005492	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
553174005493	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
553174005494	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
553174005495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174005496	Walker A/P-loop; other site
553174005497	ATP binding site [chemical binding]; other site
553174005498	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
553174005499	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
553174005500	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
553174005501	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
553174005502	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
553174005503	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
553174005504	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
553174005505	Conjugative transposon protein TraO; Region: TraO; pfam10626
553174005506	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
553174005507	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
553174005508	catalytic residue [active]
553174005509	Peptidase U49; Region: Peptidase_U49; pfam10463
553174005510	PcfJ-like protein; Region: PcfJ; pfam14284
553174005511	PcfK-like protein; Region: PcfK; pfam14058
553174005512	Protein of unknown function (DUF3260); Region: DUF3260; cl11881
553174005513	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
553174005514	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
553174005515	Int/Topo IB signature motif; other site
553174005516	flavoprotein, HI0933 family; Region: TIGR00275
553174005517	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
553174005518	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
553174005519	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
553174005520	FeS/SAM binding site; other site
553174005521	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
553174005522	Pyruvate formate lyase 1; Region: PFL1; cd01678
553174005523	coenzyme A binding site [chemical binding]; other site
553174005524	active site
553174005525	catalytic residues [active]
553174005526	glycine loop; other site
553174005527	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
553174005528	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
553174005529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
553174005530	HlyD family secretion protein; Region: HlyD_3; pfam13437
553174005531	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
553174005532	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
553174005533	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174005534	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174005535	SusD family; Region: SusD; pfam07980
553174005536	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005537	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005538	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174005539	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005540	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
553174005541	nucleoside/Zn binding site; other site
553174005542	dimer interface [polypeptide binding]; other site
553174005543	catalytic motif [active]
553174005544	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
553174005545	Zn2+ binding site [ion binding]; other site
553174005546	Mg2+ binding site [ion binding]; other site
553174005547	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
553174005548	UbiA prenyltransferase family; Region: UbiA; pfam01040
553174005549	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
553174005550	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
553174005551	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
553174005552	excinuclease ABC subunit B; Provisional; Region: PRK05298
553174005553	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174005554	ATP binding site [chemical binding]; other site
553174005555	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174005556	nucleotide binding region [chemical binding]; other site
553174005557	ATP-binding site [chemical binding]; other site
553174005558	Ultra-violet resistance protein B; Region: UvrB; pfam12344
553174005559	UvrB/uvrC motif; Region: UVR; pfam02151
553174005560	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
553174005561	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192
553174005562	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
553174005563	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
553174005564	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
553174005565	Sugar specificity; other site
553174005566	Pyrimidine base specificity; other site
553174005567	ATP-binding site [chemical binding]; other site
553174005568	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
553174005569	putative active site [active]
553174005570	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
553174005571	putative catalytic site [active]
553174005572	putative metal binding site [ion binding]; other site
553174005573	putative phosphate binding site [ion binding]; other site
553174005574	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
553174005575	Zn binding site [ion binding]; other site
553174005576	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
553174005577	generic binding surface I; other site
553174005578	generic binding surface II; other site
553174005579	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
553174005580	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
553174005581	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
553174005582	active site
553174005583	substrate binding site [chemical binding]; other site
553174005584	Mg2+ binding site [ion binding]; other site
553174005585	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
553174005586	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
553174005587	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
553174005588	Uncharacterized conserved protein [Function unknown]; Region: COG2461
553174005589	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
553174005590	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
553174005591	active site
553174005592	dimer interface [polypeptide binding]; other site
553174005593	metal binding site [ion binding]; metal-binding site
553174005594	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005595	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174005596	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005597	Predicted peptidase [General function prediction only]; Region: COG4099
553174005598	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005599	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005600	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
553174005601	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174005602	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174005603	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174005604	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174005605	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005606	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005607	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
553174005608	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005609	putative transporter; Validated; Region: PRK03818
553174005610	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
553174005611	TrkA-C domain; Region: TrkA_C; pfam02080
553174005612	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
553174005613	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
553174005614	Leucine rich repeat; Region: LRR_8; pfam13855
553174005615	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005616	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
553174005617	active site
553174005618	catalytic residues [active]
553174005619	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
553174005620	catalytic residues [active]
553174005621	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005622	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
553174005623	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
553174005624	Uncharacterized conserved protein [Function unknown]; Region: COG1284
553174005625	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
553174005626	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
553174005627	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
553174005628	amino acid carrier protein; Region: agcS; TIGR00835
553174005629	Predicted membrane protein [Function unknown]; Region: COG2259
553174005630	FeoA domain; Region: FeoA; pfam04023
553174005631	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
553174005632	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
553174005633	G1 box; other site
553174005634	GTP/Mg2+ binding site [chemical binding]; other site
553174005635	Switch I region; other site
553174005636	G2 box; other site
553174005637	G3 box; other site
553174005638	Switch II region; other site
553174005639	G4 box; other site
553174005640	G5 box; other site
553174005641	Nucleoside recognition; Region: Gate; pfam07670
553174005642	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
553174005643	Nucleoside recognition; Region: Gate; pfam07670
553174005644	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
553174005645	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
553174005646	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
553174005647	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
553174005648	substrate binding pocket [chemical binding]; other site
553174005649	chain length determination region; other site
553174005650	substrate-Mg2+ binding site; other site
553174005651	catalytic residues [active]
553174005652	aspartate-rich region 1; other site
553174005653	active site lid residues [active]
553174005654	aspartate-rich region 2; other site
553174005655	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
553174005656	active site
553174005657	cytidylate kinase; Provisional; Region: cmk; PRK00023
553174005658	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
553174005659	CMP-binding site; other site
553174005660	The sites determining sugar specificity; other site
553174005661	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
553174005662	active site
553174005663	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
553174005664	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
553174005665	Double zinc ribbon; Region: DZR; pfam12773
553174005666	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
553174005667	MarR family; Region: MarR; pfam01047
553174005668	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
553174005669	putative active site [active]
553174005670	putative catalytic site [active]
553174005671	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
553174005672	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005673	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005674	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005675	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174005676	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174005677	SusD family; Region: SusD; pfam07980
553174005678	Predicted transcriptional regulators [Transcription]; Region: COG1733
553174005679	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
553174005680	Cupin domain; Region: Cupin_2; pfam07883
553174005681	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
553174005682	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
553174005683	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
553174005684	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
553174005685	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
553174005686	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
553174005687	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174005688	sugar binding site [chemical binding]; other site
553174005689	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
553174005690	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826
553174005691	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
553174005692	RmuC family; Region: RmuC; pfam02646
553174005693	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
553174005694	DNA binding site [nucleotide binding]
553174005695	domain linker motif; other site
553174005696	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
553174005697	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
553174005698	ligand binding site [chemical binding]; other site
553174005699	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
553174005700	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
553174005701	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
553174005702	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
553174005703	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
553174005704	active site
553174005705	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
553174005706	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
553174005707	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
553174005708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
553174005709	motif II; other site
553174005710	Carbohydrate phosphorylase; Region: Phosphorylase; pfam00343
553174005711	Transposase; Region: DDE_Tnp_ISL3; pfam01610
553174005712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
553174005713	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
553174005714	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
553174005715	active site
553174005716	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174005717	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005718	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
553174005719	metal-binding site [ion binding]
553174005720	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
553174005721	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
553174005722	putative NAD(P) binding site [chemical binding]; other site
553174005723	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
553174005724	TAP-like protein; Region: Abhydrolase_4; pfam08386
553174005725	Predicted transcriptional regulators [Transcription]; Region: COG1733
553174005726	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
553174005727	CAAX protease self-immunity; Region: Abi; pfam02517
553174005728	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
553174005729	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
553174005730	active site
553174005731	Riboflavin kinase; Region: Flavokinase; pfam01687
553174005732	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005733	active site
553174005734	DNA binding site [nucleotide binding]
553174005735	Int/Topo IB signature motif; other site
553174005736	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
553174005737	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
553174005738	MPN+ (JAMM) motif; other site
553174005739	Zinc-binding site [ion binding]; other site
553174005740	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
553174005741	active site
553174005742	DNA binding site [nucleotide binding]
553174005743	Int/Topo IB signature motif; other site
553174005744	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
553174005745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
553174005746	HNH endonuclease; Region: HNH_3; pfam13392
553174005747	Double zinc ribbon; Region: DZR; pfam12773
553174005748	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
553174005749	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
553174005750	Int/Topo IB signature motif; other site
553174005751	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
553174005752	PcfK-like protein; Region: PcfK; pfam14058
553174005753	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
553174005754	PcfJ-like protein; Region: PcfJ; pfam14284
553174005755	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
553174005756	catalytic residue [active]
553174005757	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
553174005758	Conjugative transposon protein TraO; Region: TraO; pfam10626
553174005759	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
553174005760	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
553174005761	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
553174005762	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174005763	ATP binding site [chemical binding]; other site
553174005764	putative Mg++ binding site [ion binding]; other site
553174005765	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
553174005766	nucleotide binding region [chemical binding]; other site
553174005767	ATP-binding site [chemical binding]; other site
553174005768	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
553174005769	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
553174005770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
553174005771	active site
553174005772	phosphorylation site [posttranslational modification]
553174005773	intermolecular recognition site; other site
553174005774	Tetratricopeptide repeat; Region: TPR_12; pfam13424
553174005775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
553174005776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
553174005777	ATP binding site [chemical binding]; other site
553174005778	Mg2+ binding site [ion binding]; other site
553174005779	G-X-G motif; other site
553174005780	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
553174005781	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005782	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
553174005783	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005784	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
553174005785	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174005786	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174005787	Leucine rich repeat; Region: LRR_8; pfam13855
553174005788	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174005789	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
553174005790	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
553174005791	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
553174005792	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
553174005793	chaperone protein DnaJ; Provisional; Region: PRK14289
553174005794	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
553174005795	HSP70 interaction site [polypeptide binding]; other site
553174005796	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
553174005797	substrate binding site [polypeptide binding]; other site
553174005798	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
553174005799	Zn binding sites [ion binding]; other site
553174005800	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
553174005801	dimer interface [polypeptide binding]; other site
553174005802	GrpE; Region: GrpE; pfam01025
553174005803	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
553174005804	dimer interface [polypeptide binding]; other site
553174005805	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
553174005806	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
553174005807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174005808	Walker A/P-loop; other site
553174005809	ATP binding site [chemical binding]; other site
553174005810	Q-loop/lid; other site
553174005811	ABC transporter signature motif; other site
553174005812	Walker B; other site
553174005813	D-loop; other site
553174005814	H-loop/switch region; other site
553174005815	ABC transporter; Region: ABC_tran_2; pfam12848
553174005816	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174005817	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
553174005818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
553174005819	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
553174005820	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
553174005821	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
553174005822	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
553174005823	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
553174005824	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
553174005825	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
553174005826	nudix motif; other site
553174005827	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
553174005828	catalytic triad [active]
553174005829	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
553174005830	metal binding site 2 [ion binding]; metal-binding site
553174005831	putative DNA binding helix; other site
553174005832	metal binding site 1 [ion binding]; metal-binding site
553174005833	dimer interface [polypeptide binding]; other site
553174005834	structural Zn2+ binding site [ion binding]; other site
553174005835	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
553174005836	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
553174005837	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
553174005838	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
553174005839	active site
553174005840	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
553174005841	dimer interface [polypeptide binding]; other site
553174005842	substrate binding site [chemical binding]; other site
553174005843	catalytic residues [active]
553174005844	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
553174005845	Tandemly repeated domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like; cl17916
553174005846	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174005847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174005848	active site
553174005849	ambiguous bases; PCR confirmed polymorphic indel with 454 reads supporting both presence and absence of T
553174005850	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
553174005851	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
553174005852	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
553174005853	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
553174005854	active site
553174005855	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
553174005856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
553174005857	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
553174005858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
553174005859	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
553174005860	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174005861	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174005862	DNA binding residues [nucleotide binding]
553174005863	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005864	HutD; Region: HutD; cl01532
553174005865	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
553174005866	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
553174005867	active site
553174005868	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
553174005869	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
553174005870	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005871	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
553174005872	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
553174005873	active site
553174005874	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
553174005875	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
553174005876	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005877	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
553174005878	active site
553174005879	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
553174005880	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174005881	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005882	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005883	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174005884	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005885	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
553174005886	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
553174005887	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174005888	sugar binding site [chemical binding]; other site
553174005889	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
553174005890	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
553174005891	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
553174005892	active site
553174005893	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
553174005894	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174005895	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005896	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005897	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174005898	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
553174005899	active site
553174005900	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
553174005901	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
553174005902	NodB motif; other site
553174005903	putative active site [active]
553174005904	putative catalytic site [active]
553174005905	putative Zn binding site [ion binding]; other site
553174005906	N-glycosyltransferase; Provisional; Region: PRK11204
553174005907	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
553174005908	DXD motif; other site
553174005909	Uncharacterized conserved protein [Function unknown]; Region: COG4938
553174005910	Predicted membrane protein [Function unknown]; Region: COG2860
553174005911	UPF0126 domain; Region: UPF0126; pfam03458
553174005912	UPF0126 domain; Region: UPF0126; pfam03458
553174005913	glycerate dehydrogenase; Provisional; Region: PRK06487
553174005914	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
553174005915	putative ligand binding site [chemical binding]; other site
553174005916	putative NAD binding site [chemical binding]; other site
553174005917	catalytic site [active]
553174005918	recombination factor protein RarA; Reviewed; Region: PRK13342
553174005919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
553174005920	Walker A motif; other site
553174005921	ATP binding site [chemical binding]; other site
553174005922	Walker B motif; other site
553174005923	arginine finger; other site
553174005924	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
553174005925	Sulfatase; Region: Sulfatase; cl17466
553174005926	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
553174005927	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174005928	SusD family; Region: SusD; pfam07980
553174005929	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174005930	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005931	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174005932	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
553174005933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174005934	non-specific DNA binding site [nucleotide binding]; other site
553174005935	salt bridge; other site
553174005936	sequence-specific DNA binding site [nucleotide binding]; other site
553174005937	HipA N-terminal domain; Region: couple_hipA; TIGR03071
553174005938	HipA-like N-terminal domain; Region: HipA_N; pfam07805
553174005939	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
553174005940	HipA-like C-terminal domain; Region: HipA_C; pfam07804
553174005941	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
553174005942	AAA domain; Region: AAA_31; pfam13614
553174005943	P-loop; other site
553174005944	Magnesium ion binding site [ion binding]; other site
553174005945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174005946	non-specific DNA binding site [nucleotide binding]; other site
553174005947	salt bridge; other site
553174005948	sequence-specific DNA binding site [nucleotide binding]; other site
553174005949	Domain of unknown function (DUF955); Region: DUF955; pfam06114
553174005950	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
553174005951	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
553174005952	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
553174005953	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
553174005954	ATP binding site [chemical binding]; other site
553174005955	putative Mg++ binding site [ion binding]; other site
553174005956	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
553174005957	HsdM N-terminal domain; Region: HsdM_N; pfam12161
553174005958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
553174005959	S-adenosylmethionine binding site [chemical binding]; other site
553174005960	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
553174005961	Uncharacterized conserved protein [Function unknown]; Region: COG1479
553174005962	Protein of unknown function DUF262; Region: DUF262; pfam03235
553174005963	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
553174005964	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
553174005965	Divergent AAA domain; Region: AAA_4; pfam04326
553174005966	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
553174005967	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174005968	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174005969	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
553174005970	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
553174005971	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
553174005972	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
553174005973	Int/Topo IB signature motif; other site
553174005974	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
553174005975	LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563
553174005976	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
553174005977	Z1 domain; Region: Z1; pfam10593
553174005978	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
553174005979	ATP binding site [chemical binding]; other site
553174005980	Mg2+ binding site [ion binding]; other site
553174005981	G-X-G motif; other site
553174005982	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
553174005983	cofactor binding site; other site
553174005984	DNA binding site [nucleotide binding]
553174005985	substrate interaction site [chemical binding]; other site
553174005986	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
553174005987	non-specific DNA binding site [nucleotide binding]; other site
553174005988	salt bridge; other site
553174005989	sequence-specific DNA binding site [nucleotide binding]; other site
553174005990	Peptidase M15; Region: Peptidase_M15_3; cl01194
553174005991	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
553174005992	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
553174005993	Acyltransferase family; Region: Acyl_transf_3; pfam01757
553174005994	S-ribosylhomocysteinase; Provisional; Region: PRK02260
553174005995	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174005996	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
553174005997	GLPGLI family protein; Region: GLPGLI; TIGR01200
553174005998	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
553174005999	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
553174006000	ligand binding site [chemical binding]; other site
553174006001	prolyl-tRNA synthetase; Provisional; Region: PRK08661
553174006002	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
553174006003	dimer interface [polypeptide binding]; other site
553174006004	motif 1; other site
553174006005	active site
553174006006	motif 2; other site
553174006007	motif 3; other site
553174006008	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
553174006009	anticodon binding site; other site
553174006010	zinc-binding site [ion binding]; other site
553174006011	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
553174006012	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
553174006013	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
553174006014	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
553174006015	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
553174006016	DNA binding residues [nucleotide binding]
553174006017	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174006018	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174006019	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174006020	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
553174006021	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174006022	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174006023	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
553174006024	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
553174006025	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
553174006026	active site
553174006027	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
553174006028	KWG Leptospira; Region: KWG; pfam07656
553174006029	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
553174006030	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
553174006031	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
553174006032	arsenical-resistance protein; Region: acr3; TIGR00832
553174006033	Low molecular weight phosphatase family; Region: LMWPc; cd00115
553174006034	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
553174006035	active site
553174006036	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
553174006037	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
553174006038	P loop; other site
553174006039	Nucleotide binding site [chemical binding]; other site
553174006040	DTAP/Switch II; other site
553174006041	Switch I; other site
553174006042	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
553174006043	P loop; other site
553174006044	Nucleotide binding site [chemical binding]; other site
553174006045	DTAP/Switch II; other site
553174006046	Switch I; other site
553174006047	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
553174006048	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
553174006049	Family description; Region: DsbD_2; pfam13386
553174006050	lipoxygenase; Region: PLN02305
553174006051	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
553174006052	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
553174006053	dimerization interface [polypeptide binding]; other site
553174006054	putative DNA binding site [nucleotide binding]; other site
553174006055	putative Zn2+ binding site [ion binding]; other site
553174006056	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
553174006057	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
553174006058	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
553174006059	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174006060	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174006061	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
553174006062	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174006063	starch binding outer membrane protein SusD; Region: SusD; cl17845
553174006064	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
553174006065	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
553174006066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
553174006067	non-specific DNA binding site [nucleotide binding]; other site
553174006068	salt bridge; other site
553174006069	sequence-specific DNA binding site [nucleotide binding]; other site
553174006070	Rubrerythrin [Energy production and conversion]; Region: COG1592
553174006071	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
553174006072	iron binding site [ion binding]; other site
553174006073	Rubrerythrin [Energy production and conversion]; Region: COG1592
553174006074	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
553174006075	binuclear metal center [ion binding]; other site
553174006076	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
553174006077	iron binding site [ion binding]; other site
553174006078	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
553174006079	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
553174006080	CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596
553174006081	putative active site [active]
553174006082	putative catalytic site [active]
553174006083	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
553174006084	Interdomain contacts; other site
553174006085	Cytokine receptor motif; other site
553174006086	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
553174006087	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
553174006088	Peptidase M60-like family; Region: M60-like; pfam13402
553174006089	LabA_like proteins; Region: LabA_like; cd06167
553174006090	putative metal binding site [ion binding]; other site
553174006091	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
553174006092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
553174006093	Walker A/P-loop; other site
553174006094	ATP binding site [chemical binding]; other site
553174006095	Q-loop/lid; other site
553174006096	ABC transporter signature motif; other site
553174006097	Walker B; other site
553174006098	D-loop; other site
553174006099	H-loop/switch region; other site
553174006100	ABC transporter; Region: ABC_tran_2; pfam12848
553174006101	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
553174006102	KilA-N domain; Region: KilA-N; pfam04383
553174006103	Tandemly repeated domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like; cl17916
553174006104	Cna protein B-type domain; Region: Cna_B_2; pfam13715
553174006105	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
553174006106	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
553174006107	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
553174006108	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
553174006109	starch binding outer membrane protein SusD; Region: SusD; cd08977
553174006110	SusD family; Region: SusD; pfam07980
553174006111	M6 family metalloprotease domain; Region: M6dom_TIGR03296
553174006112	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
553174006113	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
553174006114	Coenzyme A binding pocket [chemical binding]; other site
553174006115	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
553174006116	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
553174006117	Probable Catalytic site; other site
553174006118	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
553174006119	recombination protein RecR; Reviewed; Region: recR; PRK00076
553174006120	RecR protein; Region: RecR; pfam02132
553174006121	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
553174006122	putative active site [active]
553174006123	putative metal-binding site [ion binding]; other site
553174006124	tetramer interface [polypeptide binding]; other site
553174006125	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
553174006126	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
553174006127	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
553174006128	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
553174006129	dimer interface [polypeptide binding]; other site
553174006130	FMN binding site [chemical binding]; other site
553174006131	NADPH bind site [chemical binding]; other site
553174006132	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
553174006133	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
553174006134	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
553174006135	active site
553174006136	dimer interface [polypeptide binding]; other site
553174006137	effector binding site; other site
553174006138	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
553174006139	Dihydroneopterin aldolase; Region: FolB; pfam02152
553174006140	active site
553174006141	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
553174006142	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
553174006143	active site
553174006144	metal binding site [ion binding]; metal-binding site
553174006145	mce related protein; Region: MCE; pfam02470
553174006146	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463