-- dump date 20140619_235913 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264731000001 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264731000002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264731000003 ligand binding site [chemical binding]; other site 264731000004 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264731000005 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 264731000006 active site triad [active] 264731000007 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 264731000008 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 264731000009 CAP-like domain; other site 264731000010 active site 264731000011 primary dimer interface [polypeptide binding]; other site 264731000012 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264731000013 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264731000014 motif 1; other site 264731000015 active site 264731000016 motif 2; other site 264731000017 motif 3; other site 264731000018 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264731000019 DHHA1 domain; Region: DHHA1; pfam02272 264731000020 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 264731000021 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264731000022 DNA binding residues [nucleotide binding] 264731000023 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 264731000024 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731000025 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731000026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731000027 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 264731000028 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264731000029 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264731000030 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264731000031 protein binding site [polypeptide binding]; other site 264731000032 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 264731000033 Domain interface; other site 264731000034 Peptide binding site; other site 264731000035 Active site tetrad [active] 264731000036 Pectinesterase; Region: Pectinesterase; pfam01095 264731000037 putative pectinesterase; Region: PLN02432; cl01911 264731000038 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264731000039 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731000040 Zn2+ binding site [ion binding]; other site 264731000041 Mg2+ binding site [ion binding]; other site 264731000042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264731000043 synthetase active site [active] 264731000044 NTP binding site [chemical binding]; other site 264731000045 metal binding site [ion binding]; metal-binding site 264731000046 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264731000047 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264731000048 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 264731000049 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264731000050 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264731000051 catalytic residue [active] 264731000052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264731000053 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264731000054 ParB-like nuclease domain; Region: ParBc; pfam02195 264731000055 KorB domain; Region: KorB; pfam08535 264731000056 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264731000057 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264731000058 P-loop; other site 264731000059 Magnesium ion binding site [ion binding]; other site 264731000060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264731000061 Magnesium ion binding site [ion binding]; other site 264731000062 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 264731000063 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 264731000064 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264731000065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000067 ATP binding site [chemical binding]; other site 264731000068 Mg2+ binding site [ion binding]; other site 264731000069 G-X-G motif; other site 264731000070 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264731000071 anti sigma factor interaction site; other site 264731000072 regulatory phosphorylation site [posttranslational modification]; other site 264731000073 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 264731000074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264731000075 ATP binding site [chemical binding]; other site 264731000076 Mg2+ binding site [ion binding]; other site 264731000077 G-X-G motif; other site 264731000078 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264731000079 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264731000080 Walker A/P-loop; other site 264731000081 ATP binding site [chemical binding]; other site 264731000082 Q-loop/lid; other site 264731000083 ABC transporter signature motif; other site 264731000084 Walker B; other site 264731000085 D-loop; other site 264731000086 H-loop/switch region; other site 264731000087 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264731000088 Permease; Region: Permease; pfam02405 264731000089 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264731000090 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 264731000091 Walker A/P-loop; other site 264731000092 ATP binding site [chemical binding]; other site 264731000093 Q-loop/lid; other site 264731000094 ABC transporter signature motif; other site 264731000095 Walker B; other site 264731000096 D-loop; other site 264731000097 H-loop/switch region; other site 264731000098 trigger factor; Region: tig; TIGR00115 264731000099 Clp protease; Region: CLP_protease; pfam00574 264731000100 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264731000101 oligomer interface [polypeptide binding]; other site 264731000102 active site residues [active] 264731000103 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264731000104 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 264731000105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000106 Walker A motif; other site 264731000107 ATP binding site [chemical binding]; other site 264731000108 Walker B motif; other site 264731000109 arginine finger; other site 264731000110 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264731000111 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 264731000112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731000113 ATP binding site [chemical binding]; other site 264731000114 putative Mg++ binding site [ion binding]; other site 264731000115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731000116 nucleotide binding region [chemical binding]; other site 264731000117 ATP-binding site [chemical binding]; other site 264731000118 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 264731000119 HRDC domain; Region: HRDC; pfam00570 264731000120 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264731000121 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264731000122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 264731000123 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264731000124 active site 264731000125 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264731000126 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 264731000127 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264731000128 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264731000129 OstA-like protein; Region: OstA_2; pfam13100 264731000130 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264731000131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000132 ATP binding site [chemical binding]; other site 264731000133 Mg2+ binding site [ion binding]; other site 264731000134 G-X-G motif; other site 264731000135 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 264731000136 ATP binding site [chemical binding]; other site 264731000137 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 264731000138 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264731000139 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 264731000140 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 264731000141 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 264731000142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000143 Walker A motif; other site 264731000144 ATP binding site [chemical binding]; other site 264731000145 Walker B motif; other site 264731000146 arginine finger; other site 264731000147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000148 Walker A motif; other site 264731000149 ATP binding site [chemical binding]; other site 264731000150 Walker B motif; other site 264731000151 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264731000152 Uncharacterized conserved protein [Function unknown]; Region: COG2127 264731000153 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 264731000154 FtsH Extracellular; Region: FtsH_ext; pfam06480 264731000155 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264731000156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000157 Walker A motif; other site 264731000158 ATP binding site [chemical binding]; other site 264731000159 Walker B motif; other site 264731000160 arginine finger; other site 264731000161 Peptidase family M41; Region: Peptidase_M41; pfam01434 264731000162 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264731000163 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 264731000164 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731000165 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731000166 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 264731000167 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 264731000168 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264731000169 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264731000170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731000171 putative substrate translocation pore; other site 264731000172 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264731000173 Ligand Binding Site [chemical binding]; other site 264731000174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264731000175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264731000176 Walker A/P-loop; other site 264731000177 ATP binding site [chemical binding]; other site 264731000178 Q-loop/lid; other site 264731000179 ABC transporter signature motif; other site 264731000180 Walker B; other site 264731000181 D-loop; other site 264731000182 H-loop/switch region; other site 264731000183 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 264731000184 S1 domain; Region: S1_2; pfam13509 264731000185 S1 domain; Region: S1_2; pfam13509 264731000186 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 264731000187 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 264731000188 putative dimer interface [polypeptide binding]; other site 264731000189 putative anticodon binding site; other site 264731000190 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 264731000191 homodimer interface [polypeptide binding]; other site 264731000192 motif 1; other site 264731000193 motif 2; other site 264731000194 active site 264731000195 motif 3; other site 264731000196 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264731000197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731000198 RNA binding surface [nucleotide binding]; other site 264731000199 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 264731000200 active site 264731000201 adenylosuccinate lyase; Provisional; Region: PRK09285 264731000202 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 264731000203 tetramer interface [polypeptide binding]; other site 264731000204 active site 264731000205 ACT domain-containing protein [General function prediction only]; Region: COG4747 264731000206 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 264731000207 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 264731000208 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264731000209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731000210 acyl-activating enzyme (AAE) consensus motif; other site 264731000211 AMP binding site [chemical binding]; other site 264731000212 active site 264731000213 CoA binding site [chemical binding]; other site 264731000214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264731000215 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264731000216 TIGR02453 family protein; Region: TIGR02453 264731000217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 264731000218 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264731000219 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 264731000220 nucleotide binding site [chemical binding]; other site 264731000221 NEF interaction site [polypeptide binding]; other site 264731000222 SBD interface [polypeptide binding]; other site 264731000223 recombinase A; Provisional; Region: recA; PRK09354 264731000224 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264731000225 hexamer interface [polypeptide binding]; other site 264731000226 Walker A motif; other site 264731000227 ATP binding site [chemical binding]; other site 264731000228 Walker B motif; other site 264731000229 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 264731000230 NHAD transporter family protein; Provisional; Region: PLN00137 264731000231 Citrate transporter; Region: CitMHS; pfam03600 264731000232 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731000233 PAS domain; Region: PAS_9; pfam13426 264731000234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000236 dimer interface [polypeptide binding]; other site 264731000237 phosphorylation site [posttranslational modification] 264731000238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000239 ATP binding site [chemical binding]; other site 264731000240 Mg2+ binding site [ion binding]; other site 264731000241 G-X-G motif; other site 264731000242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731000243 substrate binding pocket [chemical binding]; other site 264731000244 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731000245 membrane-bound complex binding site; other site 264731000246 hinge residues; other site 264731000247 PAS domain; Region: PAS_9; pfam13426 264731000248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000250 dimer interface [polypeptide binding]; other site 264731000251 phosphorylation site [posttranslational modification] 264731000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000253 ATP binding site [chemical binding]; other site 264731000254 Mg2+ binding site [ion binding]; other site 264731000255 G-X-G motif; other site 264731000256 PAS domain; Region: PAS_9; pfam13426 264731000257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000259 dimer interface [polypeptide binding]; other site 264731000260 phosphorylation site [posttranslational modification] 264731000261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000262 ATP binding site [chemical binding]; other site 264731000263 Mg2+ binding site [ion binding]; other site 264731000264 G-X-G motif; other site 264731000265 PAS domain; Region: PAS_9; pfam13426 264731000266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000268 dimer interface [polypeptide binding]; other site 264731000269 phosphorylation site [posttranslational modification] 264731000270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000271 ATP binding site [chemical binding]; other site 264731000272 G-X-G motif; other site 264731000273 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264731000274 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264731000275 hinge region; other site 264731000276 GTPase RsgA; Reviewed; Region: PRK00098 264731000277 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 264731000278 RNA binding site [nucleotide binding]; other site 264731000279 homodimer interface [polypeptide binding]; other site 264731000280 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264731000281 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264731000282 GTP/Mg2+ binding site [chemical binding]; other site 264731000283 G4 box; other site 264731000284 G5 box; other site 264731000285 G1 box; other site 264731000286 Switch I region; other site 264731000287 G2 box; other site 264731000288 G3 box; other site 264731000289 Switch II region; other site 264731000290 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 264731000291 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731000292 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264731000293 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264731000294 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 264731000295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 264731000296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264731000297 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 264731000298 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 264731000299 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 264731000300 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 264731000301 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 264731000302 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731000303 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264731000304 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 264731000305 SLBB domain; Region: SLBB; pfam10531 264731000306 SLBB domain; Region: SLBB; pfam10531 264731000307 SLBB domain; Region: SLBB; pfam10531 264731000308 SLBB domain; Region: SLBB; pfam10531 264731000309 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 264731000310 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 264731000311 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731000312 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 264731000313 active site 264731000314 metal-binding site 264731000315 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 264731000316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731000318 homodimer interface [polypeptide binding]; other site 264731000319 catalytic residue [active] 264731000320 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264731000321 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 264731000322 LicD family; Region: LicD; pfam04991 264731000323 colanic acid exporter; Provisional; Region: PRK10459 264731000324 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 264731000325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731000326 WxcM-like, C-terminal; Region: FdtA; pfam05523 264731000327 WxcM-like, C-terminal; Region: FdtA; pfam05523 264731000328 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 264731000329 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264731000330 inhibitor-cofactor binding pocket; inhibition site 264731000331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731000332 catalytic residue [active] 264731000333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731000334 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 264731000335 trimer interface [polypeptide binding]; other site 264731000336 active site 264731000337 substrate binding site [chemical binding]; other site 264731000338 CoA binding site [chemical binding]; other site 264731000339 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 264731000340 putative ligand binding site [chemical binding]; other site 264731000341 putative catalytic site [active] 264731000342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731000343 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264731000344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731000345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731000346 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 264731000347 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264731000348 NAD(P) binding site [chemical binding]; other site 264731000349 homodimer interface [polypeptide binding]; other site 264731000350 substrate binding site [chemical binding]; other site 264731000351 active site 264731000352 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 264731000353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731000354 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264731000355 NAD(P) binding site [chemical binding]; other site 264731000356 active site 264731000357 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 264731000358 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 264731000359 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264731000360 active site 264731000361 homodimer interface [polypeptide binding]; other site 264731000362 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 264731000363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731000364 AAA domain; Region: AAA_25; pfam13481 264731000365 CHC2 zinc finger; Region: zf-CHC2; cl17510 264731000366 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731000367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731000368 amidase catalytic site [active] 264731000369 Zn binding residues [ion binding]; other site 264731000370 substrate binding site [chemical binding]; other site 264731000371 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 264731000372 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264731000373 Mg++ binding site [ion binding]; other site 264731000374 putative catalytic motif [active] 264731000375 substrate binding site [chemical binding]; other site 264731000376 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 264731000377 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264731000378 Mg++ binding site [ion binding]; other site 264731000379 putative catalytic motif [active] 264731000380 substrate binding site [chemical binding]; other site 264731000381 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264731000382 putative trimer interface [polypeptide binding]; other site 264731000383 putative CoA binding site [chemical binding]; other site 264731000384 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264731000385 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264731000386 HflX GTPase family; Region: HflX; cd01878 264731000387 G1 box; other site 264731000388 GTP/Mg2+ binding site [chemical binding]; other site 264731000389 Switch I region; other site 264731000390 G2 box; other site 264731000391 G3 box; other site 264731000392 Switch II region; other site 264731000393 G4 box; other site 264731000394 G5 box; other site 264731000395 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 264731000396 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 264731000397 active site 264731000398 trimer interface [polypeptide binding]; other site 264731000399 allosteric site; other site 264731000400 active site lid [active] 264731000401 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264731000402 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731000403 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731000404 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264731000405 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731000406 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731000407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731000408 fumarate hydratase; Provisional; Region: PRK15389 264731000409 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 264731000410 Fumarase C-terminus; Region: Fumerase_C; pfam05683 264731000411 M6 family metalloprotease domain; Region: M6dom_TIGR03296 264731000412 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264731000413 Clp amino terminal domain; Region: Clp_N; pfam02861 264731000414 Clp amino terminal domain; Region: Clp_N; pfam02861 264731000415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000416 Walker A motif; other site 264731000417 ATP binding site [chemical binding]; other site 264731000418 Walker B motif; other site 264731000419 arginine finger; other site 264731000420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000421 Walker A motif; other site 264731000422 ATP binding site [chemical binding]; other site 264731000423 Walker B motif; other site 264731000424 arginine finger; other site 264731000425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264731000426 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731000427 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731000428 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731000429 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264731000430 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 264731000431 G1 box; other site 264731000432 putative GEF interaction site [polypeptide binding]; other site 264731000433 GTP/Mg2+ binding site [chemical binding]; other site 264731000434 Switch I region; other site 264731000435 G2 box; other site 264731000436 G3 box; other site 264731000437 Switch II region; other site 264731000438 G4 box; other site 264731000439 G5 box; other site 264731000440 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264731000441 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264731000442 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264731000443 16S/18S rRNA binding site [nucleotide binding]; other site 264731000444 S13e-L30e interaction site [polypeptide binding]; other site 264731000445 25S rRNA binding site [nucleotide binding]; other site 264731000446 S-ribosylhomocysteinase; Provisional; Region: PRK02260 264731000447 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264731000448 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264731000449 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264731000450 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 264731000451 bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412 264731000452 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264731000453 GSCFA family; Region: GSCFA; pfam08885 264731000454 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 264731000455 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264731000456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731000457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264731000458 active site 264731000459 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264731000460 dimer interface [polypeptide binding]; other site 264731000461 substrate binding site [chemical binding]; other site 264731000462 catalytic residues [active] 264731000463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731000464 FeS/SAM binding site; other site 264731000465 cell division protein FtsZ; Validated; Region: PRK09330 264731000466 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264731000467 nucleotide binding site [chemical binding]; other site 264731000468 SulA interaction site; other site 264731000469 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264731000470 putative active site [active] 264731000471 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731000472 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264731000473 Divergent AAA domain; Region: AAA_4; pfam04326 264731000474 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264731000475 Helix-turn-helix domain; Region: HTH_36; pfam13730 264731000476 VirE N-terminal domain; Region: VirE_N; pfam08800 264731000477 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731000478 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 264731000479 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 264731000480 catalytic domain interface [polypeptide binding]; other site 264731000481 homodimer interface [polypeptide binding]; other site 264731000482 putative active site [active] 264731000483 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731000484 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731000485 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731000486 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731000487 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731000488 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731000489 SusD family; Region: SusD; pfam07980 264731000490 flavoprotein, HI0933 family; Region: TIGR00275 264731000491 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264731000492 CoA binding domain; Region: CoA_binding_2; pfam13380 264731000493 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264731000494 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264731000495 MG2 domain; Region: A2M_N; pfam01835 264731000496 Alpha-2-macroglobulin family; Region: A2M; pfam00207 264731000497 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 264731000498 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 264731000499 membrane ATPase/protein kinase; Provisional; Region: PRK09435 264731000500 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 264731000501 Walker A; other site 264731000502 LytB protein; Region: LYTB; cl00507 264731000503 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 264731000504 B3/4 domain; Region: B3_4; smart00873 264731000505 B3/4 domain; Region: B3_4; pfam03483 264731000506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264731000507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731000508 S-adenosylmethionine binding site [chemical binding]; other site 264731000509 Domain of unknown function DUF59; Region: DUF59; cl00941 264731000510 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 264731000511 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264731000512 Walker A motif; other site 264731000513 Protein of unknown function (DUF805); Region: DUF805; pfam05656 264731000514 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264731000515 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264731000516 homodimer interface [polypeptide binding]; other site 264731000517 substrate-cofactor binding pocket; other site 264731000518 catalytic residue [active] 264731000519 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 264731000520 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264731000521 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264731000522 generic binding surface II; other site 264731000523 generic binding surface I; other site 264731000524 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264731000525 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 264731000526 active site 264731000527 catalytic triad [active] 264731000528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264731000529 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 264731000530 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 264731000531 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 264731000532 active site 264731000533 metal binding site [ion binding]; metal-binding site 264731000534 homotetramer interface [polypeptide binding]; other site 264731000535 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264731000536 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264731000537 NAD binding site [chemical binding]; other site 264731000538 substrate binding site [chemical binding]; other site 264731000539 homodimer interface [polypeptide binding]; other site 264731000540 active site 264731000541 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 264731000542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731000543 ATP-grasp domain; Region: ATP-grasp; pfam02222 264731000544 WxcM-like, C-terminal; Region: FdtA; pfam05523 264731000545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 264731000546 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264731000547 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264731000548 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264731000549 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264731000550 Cysteine-rich domain; Region: CCG; pfam02754 264731000551 Cysteine-rich domain; Region: CCG; pfam02754 264731000552 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 264731000553 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 264731000554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264731000555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264731000556 substrate binding pocket [chemical binding]; other site 264731000557 Divergent AAA domain; Region: AAA_4; pfam04326 264731000558 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 264731000559 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731000560 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264731000561 Ligand binding site; other site 264731000562 Putative Catalytic site; other site 264731000563 DXD motif; other site 264731000564 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 264731000565 ApbE family; Region: ApbE; pfam02424 264731000566 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264731000567 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264731000568 ligand binding site [chemical binding]; other site 264731000569 flexible hinge region; other site 264731000570 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264731000571 putative switch regulator; other site 264731000572 non-specific DNA interactions [nucleotide binding]; other site 264731000573 DNA binding site [nucleotide binding] 264731000574 sequence specific DNA binding site [nucleotide binding]; other site 264731000575 putative cAMP binding site [chemical binding]; other site 264731000576 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264731000577 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264731000578 active site 264731000579 Zn binding site [ion binding]; other site 264731000580 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 264731000581 catalytic motif [active] 264731000582 Zn binding site [ion binding]; other site 264731000583 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264731000584 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264731000585 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264731000586 protein binding site [polypeptide binding]; other site 264731000587 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264731000588 Catalytic dyad [active] 264731000589 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 264731000590 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 264731000591 Protein of unknown function (DUF721); Region: DUF721; pfam05258 264731000592 recombination protein F; Reviewed; Region: recF; PRK00064 264731000593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731000594 Walker A/P-loop; other site 264731000595 ATP binding site [chemical binding]; other site 264731000596 Q-loop/lid; other site 264731000597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731000598 ABC transporter signature motif; other site 264731000599 Walker B; other site 264731000600 D-loop; other site 264731000601 H-loop/switch region; other site 264731000602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000603 binding surface 264731000604 TPR motif; other site 264731000605 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000606 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264731000607 homopentamer interface [polypeptide binding]; other site 264731000608 active site 264731000609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000611 ATP binding site [chemical binding]; other site 264731000612 Mg2+ binding site [ion binding]; other site 264731000613 G-X-G motif; other site 264731000614 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 264731000615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264731000616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264731000617 DNA binding residues [nucleotide binding] 264731000618 dimerization interface [polypeptide binding]; other site 264731000619 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 264731000620 homotrimer interaction site [polypeptide binding]; other site 264731000621 putative active site [active] 264731000622 TIGR03545 family protein; Region: TIGR03545 264731000623 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 264731000624 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264731000625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264731000626 ligand binding site [chemical binding]; other site 264731000627 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731000628 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731000629 AAA domain; Region: AAA_14; pfam13173 264731000630 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 264731000631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731000632 VirE N-terminal domain; Region: VirE_N; pfam08800 264731000633 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264731000634 active site 264731000635 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731000636 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731000637 catalytic core [active] 264731000638 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731000639 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 264731000640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731000641 motif II; other site 264731000642 phosphodiesterase; Provisional; Region: PRK12704 264731000643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731000644 Zn2+ binding site [ion binding]; other site 264731000645 Mg2+ binding site [ion binding]; other site 264731000646 Cell division protein ZapA; Region: ZapA; pfam05164 264731000647 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264731000648 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264731000649 substrate binding site; other site 264731000650 tetramer interface; other site 264731000651 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264731000652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731000653 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 264731000654 active site 264731000655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731000656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731000657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731000658 DNA binding residues [nucleotide binding] 264731000659 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 264731000660 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264731000661 substrate binding site [chemical binding]; other site 264731000662 hexamer interface [polypeptide binding]; other site 264731000663 metal binding site [ion binding]; metal-binding site 264731000664 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264731000665 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264731000666 putative active site [active] 264731000667 substrate binding site [chemical binding]; other site 264731000668 putative cosubstrate binding site; other site 264731000669 catalytic site [active] 264731000670 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264731000671 substrate binding site [chemical binding]; other site 264731000672 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264731000673 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264731000674 Cl- selectivity filter; other site 264731000675 Cl- binding residues [ion binding]; other site 264731000676 pore gating glutamate residue; other site 264731000677 dimer interface [polypeptide binding]; other site 264731000678 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 264731000679 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 264731000680 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264731000681 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264731000682 G1 box; other site 264731000683 putative GEF interaction site [polypeptide binding]; other site 264731000684 GTP/Mg2+ binding site [chemical binding]; other site 264731000685 Switch I region; other site 264731000686 G2 box; other site 264731000687 G3 box; other site 264731000688 Switch II region; other site 264731000689 G4 box; other site 264731000690 G5 box; other site 264731000691 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264731000692 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264731000693 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264731000694 NADP binding site [chemical binding]; other site 264731000695 active site 264731000696 putative substrate binding site [chemical binding]; other site 264731000697 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264731000698 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 264731000699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731000700 nucleotide binding site [chemical binding]; other site 264731000701 Phosphotransferase enzyme family; Region: APH; pfam01636 264731000702 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 264731000703 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 264731000704 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264731000705 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264731000706 CoA-binding site [chemical binding]; other site 264731000707 ATP-binding [chemical binding]; other site 264731000708 transcription antitermination factor NusB; Region: nusB; TIGR01951 264731000709 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 264731000710 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264731000711 5S rRNA interface [nucleotide binding]; other site 264731000712 CTC domain interface [polypeptide binding]; other site 264731000713 L16 interface [polypeptide binding]; other site 264731000714 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264731000715 putative active site [active] 264731000716 catalytic residue [active] 264731000717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731000718 RNA binding surface [nucleotide binding]; other site 264731000719 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 264731000720 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264731000721 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264731000722 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 264731000723 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 264731000724 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 264731000725 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264731000726 active site 264731000727 metal binding site [ion binding]; metal-binding site 264731000728 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264731000729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731000730 Zn2+ binding site [ion binding]; other site 264731000731 Mg2+ binding site [ion binding]; other site 264731000732 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 264731000733 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264731000734 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264731000735 TrkA-C domain; Region: TrkA_C; pfam02080 264731000736 TrkA-C domain; Region: TrkA_C; pfam02080 264731000737 peptidase T; Region: peptidase-T; TIGR01882 264731000738 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 264731000739 metal binding site [ion binding]; metal-binding site 264731000740 dimer interface [polypeptide binding]; other site 264731000741 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731000742 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264731000743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264731000744 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264731000745 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 264731000746 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 264731000747 putative metal binding residues [ion binding]; other site 264731000748 signature motif; other site 264731000749 dimer interface [polypeptide binding]; other site 264731000750 active site 264731000751 polyP binding site; other site 264731000752 substrate binding site [chemical binding]; other site 264731000753 acceptor-phosphate pocket; other site 264731000754 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264731000755 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264731000756 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731000757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731000758 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731000759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731000760 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731000761 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264731000762 Protein export membrane protein; Region: SecD_SecF; cl14618 264731000763 Protein export membrane protein; Region: SecD_SecF; cl14618 264731000764 Outer membrane efflux protein; Region: OEP; pfam02321 264731000765 Outer membrane efflux protein; Region: OEP; pfam02321 264731000766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 264731000767 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 264731000768 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 264731000769 putative substrate binding site [chemical binding]; other site 264731000770 active site 264731000771 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731000772 sugar binding site [chemical binding]; other site 264731000773 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 264731000774 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731000775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 264731000776 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 264731000777 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731000778 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731000779 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731000780 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731000781 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731000782 SusD family; Region: SusD; pfam07980 264731000783 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731000784 CotH protein; Region: CotH; pfam08757 264731000785 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731000786 Two component regulator propeller; Region: Reg_prop; pfam07494 264731000787 Two component regulator propeller; Region: Reg_prop; pfam07494 264731000788 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731000789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000791 dimer interface [polypeptide binding]; other site 264731000792 phosphorylation site [posttranslational modification] 264731000793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000794 ATP binding site [chemical binding]; other site 264731000795 Mg2+ binding site [ion binding]; other site 264731000796 G-X-G motif; other site 264731000797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264731000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731000799 active site 264731000800 phosphorylation site [posttranslational modification] 264731000801 intermolecular recognition site; other site 264731000802 dimerization interface [polypeptide binding]; other site 264731000803 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264731000804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731000805 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 264731000806 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731000807 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731000808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264731000809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731000810 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731000811 substrate binding pocket [chemical binding]; other site 264731000812 membrane-bound complex binding site; other site 264731000813 hinge residues; other site 264731000814 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264731000815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731000816 S-adenosylmethionine binding site [chemical binding]; other site 264731000817 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 264731000818 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 264731000819 active site 264731000820 metal binding site [ion binding]; metal-binding site 264731000821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731000822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731000823 dimer interface [polypeptide binding]; other site 264731000824 phosphorylation site [posttranslational modification] 264731000825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731000826 ATP binding site [chemical binding]; other site 264731000827 Mg2+ binding site [ion binding]; other site 264731000828 G-X-G motif; other site 264731000829 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264731000830 MutS domain III; Region: MutS_III; pfam05192 264731000831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731000832 Walker A/P-loop; other site 264731000833 ATP binding site [chemical binding]; other site 264731000834 Q-loop/lid; other site 264731000835 ABC transporter signature motif; other site 264731000836 Walker B; other site 264731000837 D-loop; other site 264731000838 H-loop/switch region; other site 264731000839 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 264731000840 Smr domain; Region: Smr; pfam01713 264731000841 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264731000842 catalytic residue [active] 264731000843 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 264731000844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264731000845 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264731000846 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264731000847 NAD(P) binding site [chemical binding]; other site 264731000848 homotetramer interface [polypeptide binding]; other site 264731000849 homodimer interface [polypeptide binding]; other site 264731000850 active site 264731000851 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264731000852 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264731000853 active site 264731000854 Family of unknown function (DUF490); Region: DUF490; pfam04357 264731000855 Surface antigen; Region: Bac_surface_Ag; pfam01103 264731000856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731000857 active site 264731000858 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 264731000859 DHH family; Region: DHH; pfam01368 264731000860 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 264731000861 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 264731000862 active site 264731000863 substrate binding site [chemical binding]; other site 264731000864 metal binding site [ion binding]; metal-binding site 264731000865 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264731000866 oligomerisation interface [polypeptide binding]; other site 264731000867 mobile loop; other site 264731000868 roof hairpin; other site 264731000869 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264731000870 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264731000871 ring oligomerisation interface [polypeptide binding]; other site 264731000872 ATP/Mg binding site [chemical binding]; other site 264731000873 stacking interactions; other site 264731000874 hinge regions; other site 264731000875 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 264731000876 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 264731000877 tandem repeat interface [polypeptide binding]; other site 264731000878 oligomer interface [polypeptide binding]; other site 264731000879 active site residues [active] 264731000880 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264731000881 oligomer interface [polypeptide binding]; other site 264731000882 tandem repeat interface [polypeptide binding]; other site 264731000883 active site residues [active] 264731000884 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 264731000885 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 264731000886 purine nucleoside phosphorylase; Provisional; Region: PRK08202 264731000887 thiamine monophosphate kinase; Provisional; Region: PRK05731 264731000888 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264731000889 ATP binding site [chemical binding]; other site 264731000890 dimerization interface [polypeptide binding]; other site 264731000891 pantothenate kinase; Provisional; Region: PRK13317 264731000892 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 264731000893 putative acetyltransferase; Provisional; Region: PRK03624 264731000894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731000895 Coenzyme A binding pocket [chemical binding]; other site 264731000896 Condensation domain; Region: Condensation; pfam00668 264731000897 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264731000898 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264731000899 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264731000900 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731000901 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264731000902 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731000903 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731000904 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731000905 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731000906 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 264731000907 putative efflux protein, MATE family; Region: matE; TIGR00797 264731000908 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 264731000909 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 264731000910 AAA domain; Region: AAA_14; pfam13173 264731000911 RmuC family; Region: RmuC; pfam02646 264731000912 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264731000913 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731000914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731000915 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 264731000916 putative active site [active] 264731000917 RyR domain; Region: RyR; pfam02026 264731000918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000919 TPR motif; other site 264731000920 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000921 binding surface 264731000922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000924 binding surface 264731000925 TPR motif; other site 264731000926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000928 binding surface 264731000929 TPR motif; other site 264731000930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000932 binding surface 264731000933 TPR motif; other site 264731000934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000937 binding surface 264731000938 TPR motif; other site 264731000939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000941 binding surface 264731000942 TPR motif; other site 264731000943 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264731000944 Sel1-like repeats; Region: SEL1; smart00671 264731000945 Sel1-like repeats; Region: SEL1; smart00671 264731000946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000947 binding surface 264731000948 TPR motif; other site 264731000949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000953 binding surface 264731000954 TPR motif; other site 264731000955 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000957 binding surface 264731000958 TPR motif; other site 264731000959 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000962 binding surface 264731000963 TPR motif; other site 264731000964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731000966 binding surface 264731000967 TPR motif; other site 264731000968 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731000969 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 264731000970 nudix motif; other site 264731000971 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 264731000972 Protein kinase; unclassified specificity; Region: STYKc; smart00221 264731000973 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264731000974 active site 264731000975 ATP binding site [chemical binding]; other site 264731000976 substrate binding site [chemical binding]; other site 264731000977 activation loop (A-loop); other site 264731000978 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 264731000979 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 264731000980 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 264731000981 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264731000982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731000983 Uncharacterized conserved protein [Function unknown]; Region: COG1479 264731000984 Protein of unknown function DUF262; Region: DUF262; pfam03235 264731000985 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 264731000986 ADP-ribose binding site [chemical binding]; other site 264731000987 TIR domain; Region: TIR_2; pfam13676 264731000988 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 264731000989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731000990 Walker A motif; other site 264731000991 ATP binding site [chemical binding]; other site 264731000992 Walker B motif; other site 264731000993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264731000994 Integrase core domain; Region: rve; pfam00665 264731000995 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 264731000996 additional DNA contacts [nucleotide binding]; other site 264731000997 mismatch recognition site; other site 264731000998 active site 264731000999 zinc binding site [ion binding]; other site 264731001000 DNA intercalation site [nucleotide binding]; other site 264731001001 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 264731001002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264731001003 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 264731001004 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264731001005 cofactor binding site; other site 264731001006 DNA binding site [nucleotide binding] 264731001007 substrate interaction site [chemical binding]; other site 264731001008 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 264731001009 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264731001010 cofactor binding site; other site 264731001011 DNA binding site [nucleotide binding] 264731001012 substrate interaction site [chemical binding]; other site 264731001013 virion protein; Provisional; Region: V; PHA02564 264731001014 VirE N-terminal domain; Region: VirE_N; pfam08800 264731001015 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731001016 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 264731001017 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264731001018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001019 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731001020 Walker A motif; other site 264731001021 ATP binding site [chemical binding]; other site 264731001022 Walker B motif; other site 264731001023 arginine finger; other site 264731001024 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001026 Walker A motif; other site 264731001027 ATP binding site [chemical binding]; other site 264731001028 Walker B motif; other site 264731001029 arginine finger; other site 264731001030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264731001031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731001032 active site 264731001033 motif I; other site 264731001034 motif II; other site 264731001035 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 264731001036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264731001037 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264731001038 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264731001039 Fic family protein [Function unknown]; Region: COG3177 264731001040 Fic/DOC family; Region: Fic; pfam02661 264731001041 MarR family; Region: MarR_2; pfam12802 264731001042 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 264731001043 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 264731001044 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 264731001045 substrate binding site [chemical binding]; other site 264731001046 ATP binding site [chemical binding]; other site 264731001047 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264731001048 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264731001049 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264731001050 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 264731001051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731001052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731001053 DNA binding residues [nucleotide binding] 264731001054 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731001055 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 264731001056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731001057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731001058 homodimer interface [polypeptide binding]; other site 264731001059 catalytic residue [active] 264731001060 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264731001061 histidinol dehydrogenase; Region: hisD; TIGR00069 264731001062 NAD binding site [chemical binding]; other site 264731001063 dimerization interface [polypeptide binding]; other site 264731001064 product binding site; other site 264731001065 substrate binding site [chemical binding]; other site 264731001066 zinc binding site [ion binding]; other site 264731001067 catalytic residues [active] 264731001068 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 264731001069 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 264731001070 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 264731001071 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264731001072 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264731001073 catalytic residue [active] 264731001074 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 264731001075 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 264731001076 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264731001077 TPP-binding site [chemical binding]; other site 264731001078 dimer interface [polypeptide binding]; other site 264731001079 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264731001080 PYR/PP interface [polypeptide binding]; other site 264731001081 dimer interface [polypeptide binding]; other site 264731001082 TPP binding site [chemical binding]; other site 264731001083 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264731001084 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731001085 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731001086 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731001087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264731001088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731001089 nucleotide binding site [chemical binding]; other site 264731001090 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731001091 catalytic core [active] 264731001092 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 264731001093 C-N hydrolase family amidase; Provisional; Region: PRK10438 264731001094 active site 264731001095 catalytic triad [active] 264731001096 dimer interface [polypeptide binding]; other site 264731001097 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264731001098 Cation efflux family; Region: Cation_efflux; pfam01545 264731001099 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 264731001100 thiS-thiF/thiG interaction site; other site 264731001101 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264731001102 active site 264731001103 thiamine phosphate binding site [chemical binding]; other site 264731001104 pyrophosphate binding site [ion binding]; other site 264731001105 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 264731001106 ThiS interaction site; other site 264731001107 putative active site [active] 264731001108 tetramer interface [polypeptide binding]; other site 264731001109 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 264731001110 ThiC-associated domain; Region: ThiC-associated; pfam13667 264731001111 ThiC family; Region: ThiC; pfam01964 264731001112 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 264731001113 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 264731001114 ATP binding site [chemical binding]; other site 264731001115 substrate interface [chemical binding]; other site 264731001116 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 264731001117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731001118 FeS/SAM binding site; other site 264731001119 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 264731001120 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264731001121 thiamine phosphate binding site [chemical binding]; other site 264731001122 active site 264731001123 pyrophosphate binding site [ion binding]; other site 264731001124 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264731001125 dimer interface [polypeptide binding]; other site 264731001126 substrate binding site [chemical binding]; other site 264731001127 ATP binding site [chemical binding]; other site 264731001128 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 264731001129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264731001130 substrate binding pocket [chemical binding]; other site 264731001131 catalytic triad [active] 264731001132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264731001133 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264731001134 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264731001135 active site 264731001136 nucleophile elbow; other site 264731001137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264731001138 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731001139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731001140 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264731001141 Sulfatase; Region: Sulfatase; cl17466 264731001142 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 264731001143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731001144 FeS/SAM binding site; other site 264731001145 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264731001146 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264731001147 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 264731001148 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 264731001149 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264731001150 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731001151 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731001152 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 264731001153 active site 264731001154 catalytic triad [active] 264731001155 oxyanion hole [active] 264731001156 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 264731001157 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 264731001158 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 264731001159 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 264731001160 putative N- and C-terminal domain interface [polypeptide binding]; other site 264731001161 putative active site [active] 264731001162 MgATP binding site [chemical binding]; other site 264731001163 catalytic site [active] 264731001164 metal binding site [ion binding]; metal-binding site 264731001165 putative carbohydrate binding site [chemical binding]; other site 264731001166 L-arabinose isomerase; Provisional; Region: PRK02929 264731001167 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 264731001168 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264731001169 trimer interface [polypeptide binding]; other site 264731001170 substrate binding site [chemical binding]; other site 264731001171 Mn binding site [ion binding]; other site 264731001172 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 264731001173 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 264731001174 intersubunit interface [polypeptide binding]; other site 264731001175 active site 264731001176 Zn2+ binding site [ion binding]; other site 264731001177 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 264731001178 nudix motif; other site 264731001179 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264731001180 Na binding site [ion binding]; other site 264731001181 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 264731001182 active site 264731001183 catalytic residues [active] 264731001184 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 264731001185 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 264731001186 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264731001187 L-fucose transporter; Provisional; Region: PRK10133; cl17665 264731001188 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 264731001189 active site 264731001190 catalytic residues [active] 264731001191 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 264731001192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731001193 chaperone protein DnaJ; Provisional; Region: PRK14289 264731001194 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264731001195 HSP70 interaction site [polypeptide binding]; other site 264731001196 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 264731001197 substrate binding site [polypeptide binding]; other site 264731001198 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264731001199 Zn binding sites [ion binding]; other site 264731001200 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264731001201 dimer interface [polypeptide binding]; other site 264731001202 GrpE; Region: GrpE; pfam01025 264731001203 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264731001204 dimer interface [polypeptide binding]; other site 264731001205 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264731001206 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264731001207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731001208 Walker A/P-loop; other site 264731001209 ATP binding site [chemical binding]; other site 264731001210 Q-loop/lid; other site 264731001211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001212 ABC transporter; Region: ABC_tran_2; pfam12848 264731001213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001214 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264731001215 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 264731001216 Substrate binding site; other site 264731001217 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731001218 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 264731001219 substrate binding site; other site 264731001220 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 264731001221 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 264731001222 NAD binding site [chemical binding]; other site 264731001223 homotetramer interface [polypeptide binding]; other site 264731001224 homodimer interface [polypeptide binding]; other site 264731001225 substrate binding site [chemical binding]; other site 264731001226 active site 264731001227 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731001228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731001229 NAD(P) binding site [chemical binding]; other site 264731001230 active site 264731001231 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 264731001232 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731001233 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264731001234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731001235 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 264731001236 metal-binding site 264731001237 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264731001238 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264731001239 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264731001240 KpsF/GutQ family protein; Region: kpsF; TIGR00393 264731001241 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264731001242 putative active site [active] 264731001243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264731001244 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 264731001245 ligand binding site; other site 264731001246 tetramer interface; other site 264731001247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731001248 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264731001249 NAD(P) binding site [chemical binding]; other site 264731001250 active site 264731001251 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 264731001252 putative ADP-binding pocket [chemical binding]; other site 264731001253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731001254 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731001255 extended (e) SDRs; Region: SDR_e; cd08946 264731001256 NAD(P) binding site [chemical binding]; other site 264731001257 active site 264731001258 substrate binding site [chemical binding]; other site 264731001259 Transposase IS200 like; Region: Y1_Tnp; cl00848 264731001260 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 264731001261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731001262 active site 264731001263 motif I; other site 264731001264 motif II; other site 264731001265 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 264731001266 putative active site pocket [active] 264731001267 4-fold oligomerization interface [polypeptide binding]; other site 264731001268 metal binding residues [ion binding]; metal-binding site 264731001269 3-fold/trimer interface [polypeptide binding]; other site 264731001270 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264731001271 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264731001272 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 264731001273 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 264731001274 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 264731001275 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 264731001276 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 264731001277 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 264731001278 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 264731001279 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264731001280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731001281 catalytic residue [active] 264731001282 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 264731001283 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 264731001284 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 264731001285 Protein of unknown function DUF45; Region: DUF45; pfam01863 264731001286 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264731001287 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731001288 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731001289 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731001290 stage V sporulation protein K; Region: spore_V_K; TIGR02881 264731001291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001292 Walker A motif; other site 264731001293 ATP binding site [chemical binding]; other site 264731001294 Walker B motif; other site 264731001295 arginine finger; other site 264731001296 bile acid transporter; Region: bass; TIGR00841 264731001297 Sodium Bile acid symporter family; Region: SBF; pfam01758 264731001298 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264731001299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731001300 non-specific DNA binding site [nucleotide binding]; other site 264731001301 salt bridge; other site 264731001302 sequence-specific DNA binding site [nucleotide binding]; other site 264731001303 Cupin domain; Region: Cupin_2; pfam07883 264731001304 AMP-binding domain protein; Validated; Region: PRK08315 264731001305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731001306 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 264731001307 acyl-activating enzyme (AAE) consensus motif; other site 264731001308 acyl-activating enzyme (AAE) consensus motif; other site 264731001309 putative AMP binding site [chemical binding]; other site 264731001310 putative active site [active] 264731001311 putative CoA binding site [chemical binding]; other site 264731001312 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731001313 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731001314 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 264731001315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731001316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731001317 active site 264731001318 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264731001319 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264731001320 active site 264731001321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264731001322 substrate binding site [chemical binding]; other site 264731001323 catalytic residues [active] 264731001324 dimer interface [polypeptide binding]; other site 264731001325 aspartate kinase III; Validated; Region: PRK09084 264731001326 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 264731001327 putative catalytic residues [active] 264731001328 nucleotide binding site [chemical binding]; other site 264731001329 aspartate binding site [chemical binding]; other site 264731001330 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 264731001331 dimer interface [polypeptide binding]; other site 264731001332 allosteric regulatory binding pocket; other site 264731001333 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264731001334 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 264731001335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731001336 Walker A/P-loop; other site 264731001337 ATP binding site [chemical binding]; other site 264731001338 Q-loop/lid; other site 264731001339 ABC transporter signature motif; other site 264731001340 Walker B; other site 264731001341 D-loop; other site 264731001342 H-loop/switch region; other site 264731001343 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 264731001344 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 264731001345 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 264731001346 metal binding site [ion binding]; metal-binding site 264731001347 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264731001348 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264731001349 substrate binding site [chemical binding]; other site 264731001350 glutamase interaction surface [polypeptide binding]; other site 264731001351 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 264731001352 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 264731001353 catalytic residues [active] 264731001354 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 264731001355 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264731001356 putative active site [active] 264731001357 oxyanion strand; other site 264731001358 catalytic triad [active] 264731001359 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 264731001360 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264731001361 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264731001362 putative active site [active] 264731001363 putative substrate binding site [chemical binding]; other site 264731001364 putative cosubstrate binding site; other site 264731001365 catalytic site [active] 264731001366 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264731001367 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264731001368 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264731001369 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264731001370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731001371 NAD(P) binding site [chemical binding]; other site 264731001372 active site 264731001373 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731001374 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731001375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264731001376 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264731001377 LytTr DNA-binding domain; Region: LytTR; smart00850 264731001378 Uncharacterized conserved protein [Function unknown]; Region: COG2968 264731001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 264731001380 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 264731001381 active site 264731001382 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 264731001383 AzlC protein; Region: AzlC; cl00570 264731001384 Pectate lyase; Region: Pec_lyase_C; cl01593 264731001385 WYL domain; Region: WYL; pfam13280 264731001386 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264731001387 active site 264731001388 DNA polymerase IV; Validated; Region: PRK02406 264731001389 DNA binding site [nucleotide binding] 264731001390 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264731001391 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264731001392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731001393 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731001394 Predicted transcriptional regulators [Transcription]; Region: COG1733 264731001395 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264731001396 Cupin domain; Region: Cupin_2; pfam07883 264731001397 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264731001398 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 264731001399 YolD-like protein; Region: YolD; pfam08863 264731001400 DNA polymerase IV; Reviewed; Region: PRK03103 264731001401 Y-family of DNA polymerases; Region: PolY; cl12025 264731001402 active site 264731001403 DNA binding site [nucleotide binding] 264731001404 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 264731001405 Chloramphenicol acetyltransferase; Region: CAT; cl02008 264731001406 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264731001407 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264731001408 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 264731001409 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 264731001410 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731001411 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731001412 catalytic residues [active] 264731001413 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264731001414 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264731001415 Family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate recep; Region: PBP1_glutamate_receptors_like; cd06269 264731001416 dimerization interface [polypeptide binding]; other site 264731001417 Peptidase C13 family; Region: Peptidase_C13; pfam01650 264731001418 HipA N-terminal domain; Region: Couple_hipA; cl11853 264731001419 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264731001420 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264731001421 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 264731001422 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 264731001423 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 264731001424 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 264731001425 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 264731001426 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264731001427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264731001428 Walker A motif; other site 264731001429 ATP binding site [chemical binding]; other site 264731001430 Walker B motif; other site 264731001431 arginine finger; other site 264731001432 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264731001433 metal ion-dependent adhesion site (MIDAS); other site 264731001434 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264731001435 Divergent AAA domain; Region: AAA_4; pfam04326 264731001436 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264731001437 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264731001438 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 264731001439 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 264731001440 Putative zinc ribbon domain; Region: DUF164; pfam02591 264731001441 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 264731001442 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264731001443 DNA polymerase III, delta subunit; Region: holA; TIGR01128 264731001444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731001445 non-specific DNA binding site [nucleotide binding]; other site 264731001446 salt bridge; other site 264731001447 sequence-specific DNA binding site [nucleotide binding]; other site 264731001448 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 264731001449 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 264731001450 FAD binding pocket [chemical binding]; other site 264731001451 FAD binding motif [chemical binding]; other site 264731001452 phosphate binding motif [ion binding]; other site 264731001453 beta-alpha-beta structure motif; other site 264731001454 NAD binding pocket [chemical binding]; other site 264731001455 Iron coordination center [ion binding]; other site 264731001456 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 264731001457 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 264731001458 heterodimer interface [polypeptide binding]; other site 264731001459 active site 264731001460 FMN binding site [chemical binding]; other site 264731001461 homodimer interface [polypeptide binding]; other site 264731001462 substrate binding site [chemical binding]; other site 264731001463 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 264731001464 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264731001465 Tetramer interface [polypeptide binding]; other site 264731001466 active site 264731001467 FMN-binding site [chemical binding]; other site 264731001468 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264731001469 Peptidase family M48; Region: Peptidase_M48; pfam01435 264731001470 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 264731001471 trimer interface [polypeptide binding]; other site 264731001472 active site 264731001473 G bulge; other site 264731001474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731001475 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264731001476 NAD(P) binding site [chemical binding]; other site 264731001477 active site 264731001478 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 264731001479 GAF domain; Region: GAF_2; pfam13185 264731001480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 264731001481 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 264731001482 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264731001483 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264731001484 putative active site [active] 264731001485 putative catalytic site [active] 264731001486 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 264731001487 amidophosphoribosyltransferase; Region: purF; TIGR01134 264731001488 active site 264731001489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731001490 active site 264731001491 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264731001492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731001493 ATP binding site [chemical binding]; other site 264731001494 putative Mg++ binding site [ion binding]; other site 264731001495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731001496 nucleotide binding region [chemical binding]; other site 264731001497 ATP-binding site [chemical binding]; other site 264731001498 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 264731001499 DHH family; Region: DHH; pfam01368 264731001500 DHHA1 domain; Region: DHHA1; pfam02272 264731001501 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 264731001502 active site 264731001503 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 264731001504 active site 264731001505 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 264731001506 proline aminopeptidase P II; Provisional; Region: PRK10879 264731001507 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264731001508 active site 264731001509 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264731001510 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264731001511 active site 264731001512 HIGH motif; other site 264731001513 dimer interface [polypeptide binding]; other site 264731001514 KMSKS motif; other site 264731001515 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 264731001516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731001517 FeS/SAM binding site; other site 264731001518 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264731001519 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731001520 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 264731001521 putative active site [active] 264731001522 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 264731001523 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264731001524 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 264731001525 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 264731001526 active site 264731001527 nucleophile elbow; other site 264731001528 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264731001529 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264731001530 nucleotide binding pocket [chemical binding]; other site 264731001531 K-X-D-G motif; other site 264731001532 catalytic site [active] 264731001533 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264731001534 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264731001535 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264731001536 Dimer interface [polypeptide binding]; other site 264731001537 BRCT sequence motif; other site 264731001538 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264731001539 EamA-like transporter family; Region: EamA; pfam00892 264731001540 EamA-like transporter family; Region: EamA; pfam00892 264731001541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731001542 sequence-specific DNA binding site [nucleotide binding]; other site 264731001543 salt bridge; other site 264731001544 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 264731001545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731001546 FeS/SAM binding site; other site 264731001547 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 264731001548 putative ligand binding pocket/active site [active] 264731001549 putative metal binding site [ion binding]; other site 264731001550 AMMECR1; Region: AMMECR1; pfam01871 264731001551 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 264731001552 Virulence-associated protein E; Region: VirE; pfam05272 264731001553 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 264731001554 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731001555 active site 264731001556 NTP binding site [chemical binding]; other site 264731001557 metal binding triad [ion binding]; metal-binding site 264731001558 antibiotic binding site [chemical binding]; other site 264731001559 Protein of unknown function DUF86; Region: DUF86; cl01031 264731001560 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 264731001561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731001562 active site 264731001563 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264731001564 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264731001565 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264731001566 dimer interface [polypeptide binding]; other site 264731001567 motif 1; other site 264731001568 active site 264731001569 motif 2; other site 264731001570 motif 3; other site 264731001571 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 264731001572 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 264731001573 FAD binding domain; Region: FAD_binding_4; pfam01565 264731001574 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264731001575 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264731001576 putative hydrolase; Provisional; Region: PRK02113 264731001577 Sporulation related domain; Region: SPOR; pfam05036 264731001578 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 264731001579 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264731001580 active site 264731001581 catalytic residues [active] 264731001582 metal binding site [ion binding]; metal-binding site 264731001583 TPR repeat; Region: TPR_11; pfam13414 264731001584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731001585 TPR motif; other site 264731001586 binding surface 264731001587 TPR repeat; Region: TPR_11; pfam13414 264731001588 TPR repeat; Region: TPR_11; pfam13414 264731001589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731001590 binding surface 264731001591 TPR motif; other site 264731001592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731001593 binding surface 264731001594 TPR repeat; Region: TPR_11; pfam13414 264731001595 TPR motif; other site 264731001596 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264731001597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731001598 binding surface 264731001599 TPR motif; other site 264731001600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731001601 TPR motif; other site 264731001602 TPR repeat; Region: TPR_11; pfam13414 264731001603 binding surface 264731001604 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264731001605 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264731001606 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264731001607 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264731001608 active site 264731001609 dimer interface [polypeptide binding]; other site 264731001610 motif 1; other site 264731001611 motif 2; other site 264731001612 motif 3; other site 264731001613 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264731001614 anticodon binding site; other site 264731001615 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 264731001616 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264731001617 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264731001618 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264731001619 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264731001620 23S rRNA binding site [nucleotide binding]; other site 264731001621 L21 binding site [polypeptide binding]; other site 264731001622 L13 binding site [polypeptide binding]; other site 264731001623 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264731001624 anti sigma factor interaction site; other site 264731001625 regulatory phosphorylation site [posttranslational modification]; other site 264731001626 Cache domain; Region: Cache_1; pfam02743 264731001627 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731001628 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731001629 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 264731001630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264731001631 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 264731001632 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264731001633 active site 264731001634 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264731001635 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264731001636 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 264731001637 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264731001638 RNA binding site [nucleotide binding]; other site 264731001639 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264731001640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731001641 Walker A/P-loop; other site 264731001642 ATP binding site [chemical binding]; other site 264731001643 Q-loop/lid; other site 264731001644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001645 ABC transporter signature motif; other site 264731001646 Walker B; other site 264731001647 D-loop; other site 264731001648 ABC transporter; Region: ABC_tran_2; pfam12848 264731001649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001650 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 264731001651 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 264731001652 active site 264731001653 Zn binding site [ion binding]; other site 264731001654 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264731001655 Double zinc ribbon; Region: DZR; pfam12773 264731001656 Double zinc ribbon; Region: DZR; pfam12773 264731001657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264731001658 active site 264731001659 substrate binding site [chemical binding]; other site 264731001660 ATP binding site [chemical binding]; other site 264731001661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264731001662 activation loop (A-loop); other site 264731001663 Predicted membrane protein [Function unknown]; Region: COG3371 264731001664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001665 Walker A motif; other site 264731001666 ATP binding site [chemical binding]; other site 264731001667 Walker B motif; other site 264731001668 arginine finger; other site 264731001669 stage V sporulation protein K; Region: spore_V_K; TIGR02881 264731001670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001671 Walker A motif; other site 264731001672 ATP binding site [chemical binding]; other site 264731001673 Walker B motif; other site 264731001674 arginine finger; other site 264731001675 stage V sporulation protein K; Region: spore_V_K; TIGR02881 264731001676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001677 Walker A motif; other site 264731001678 ATP binding site [chemical binding]; other site 264731001679 Walker B motif; other site 264731001680 arginine finger; other site 264731001681 stage V sporulation protein K; Region: spore_V_K; TIGR02881 264731001682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731001683 Walker A motif; other site 264731001684 ATP binding site [chemical binding]; other site 264731001685 Walker B motif; other site 264731001686 arginine finger; other site 264731001687 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264731001688 phosphopeptide binding site; other site 264731001689 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264731001690 active site 264731001691 homoserine O-succinyltransferase; Provisional; Region: PRK05368 264731001692 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 264731001693 proposed active site lysine [active] 264731001694 conserved cys residue [active] 264731001695 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264731001696 Class I aldolases; Region: Aldolase_Class_I; cl17187 264731001697 Peptidase family U32; Region: Peptidase_U32; pfam01136 264731001698 Collagenase; Region: DUF3656; pfam12392 264731001699 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 264731001700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731001701 FeS/SAM binding site; other site 264731001702 HemN C-terminal domain; Region: HemN_C; pfam06969 264731001703 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 264731001704 elongation factor G; Reviewed; Region: PRK12740 264731001705 G1 box; other site 264731001706 putative GEF interaction site [polypeptide binding]; other site 264731001707 GTP/Mg2+ binding site [chemical binding]; other site 264731001708 Switch I region; other site 264731001709 G2 box; other site 264731001710 G3 box; other site 264731001711 Switch II region; other site 264731001712 G4 box; other site 264731001713 G5 box; other site 264731001714 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264731001715 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264731001716 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264731001717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731001718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731001719 dimer interface [polypeptide binding]; other site 264731001720 phosphorylation site [posttranslational modification] 264731001721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731001722 ATP binding site [chemical binding]; other site 264731001723 Mg2+ binding site [ion binding]; other site 264731001724 G-X-G motif; other site 264731001725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264731001726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731001727 active site 264731001728 phosphorylation site [posttranslational modification] 264731001729 intermolecular recognition site; other site 264731001730 dimerization interface [polypeptide binding]; other site 264731001731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264731001732 DNA binding site [nucleotide binding] 264731001733 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 264731001734 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264731001735 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264731001736 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264731001737 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264731001738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 264731001739 DNA binding site [nucleotide binding] 264731001740 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731001741 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264731001742 DNA binding residues [nucleotide binding] 264731001743 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731001744 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731001745 TraB family; Region: TraB; pfam01963 264731001746 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 264731001747 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264731001748 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264731001749 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264731001750 Probable Catalytic site; other site 264731001751 metal-binding site 264731001752 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 264731001753 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 264731001754 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 264731001755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264731001756 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731001757 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264731001758 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264731001759 dimer interface [polypeptide binding]; other site 264731001760 active site 264731001761 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264731001762 folate binding site [chemical binding]; other site 264731001763 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 264731001764 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 264731001765 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 264731001766 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264731001767 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264731001768 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264731001769 Transglycosylase; Region: Transgly; pfam00912 264731001770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264731001771 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731001772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731001773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 264731001774 virion protein; Provisional; Region: V; PHA02564 264731001775 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264731001776 active site 264731001777 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264731001778 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 264731001779 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 264731001780 glutaminase A; Region: Gln_ase; TIGR03814 264731001781 putative transporter; Validated; Region: PRK03818 264731001782 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264731001783 TrkA-C domain; Region: TrkA_C; pfam02080 264731001784 TrkA-C domain; Region: TrkA_C; pfam02080 264731001785 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264731001786 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264731001787 active site 264731001788 8-oxo-dGMP binding site [chemical binding]; other site 264731001789 nudix motif; other site 264731001790 metal binding site [ion binding]; metal-binding site 264731001791 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264731001792 active site 264731001793 8-oxo-dGMP binding site [chemical binding]; other site 264731001794 nudix motif; other site 264731001795 metal binding site [ion binding]; metal-binding site 264731001796 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 264731001797 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264731001798 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 264731001799 cofactor binding site; other site 264731001800 DNA binding site [nucleotide binding] 264731001801 substrate interaction site [chemical binding]; other site 264731001802 HNH endonuclease; Region: HNH_2; pfam13391 264731001803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731001804 Glycogen synthase; Region: Glycogen_syn; pfam05693 264731001805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731001806 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 264731001807 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731001808 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264731001809 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264731001810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731001811 active site 264731001812 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264731001813 active site 264731001814 thiamine phosphate binding site [chemical binding]; other site 264731001815 pyrophosphate binding site [ion binding]; other site 264731001816 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264731001817 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264731001818 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 264731001819 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 264731001820 active site 264731001821 catalytic site [active] 264731001822 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 264731001823 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 264731001824 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264731001825 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 264731001826 putative catalytic site [active] 264731001827 putative metal binding site [ion binding]; other site 264731001828 putative phosphate binding site [ion binding]; other site 264731001829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731001830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731001831 dimer interface [polypeptide binding]; other site 264731001832 phosphorylation site [posttranslational modification] 264731001833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731001834 ATP binding site [chemical binding]; other site 264731001835 Mg2+ binding site [ion binding]; other site 264731001836 G-X-G motif; other site 264731001837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264731001838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731001839 active site 264731001840 phosphorylation site [posttranslational modification] 264731001841 intermolecular recognition site; other site 264731001842 dimerization interface [polypeptide binding]; other site 264731001843 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 264731001844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264731001845 DXD motif; other site 264731001846 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 264731001847 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264731001848 homodimer interface [polypeptide binding]; other site 264731001849 oligonucleotide binding site [chemical binding]; other site 264731001850 Ribonuclease P; Region: Ribonuclease_P; cl00457 264731001851 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264731001852 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264731001853 IHF dimer interface [polypeptide binding]; other site 264731001854 IHF - DNA interface [nucleotide binding]; other site 264731001855 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264731001856 pyruvate kinase; Provisional; Region: PRK05826 264731001857 domain interfaces; other site 264731001858 active site 264731001859 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264731001860 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264731001861 active site 264731001862 Zn binding site [ion binding]; other site 264731001863 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 264731001864 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 264731001865 GGGtGRT protein; Region: GGGtGRT; pfam14057 264731001866 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 264731001867 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 264731001868 putative ligand binding site [chemical binding]; other site 264731001869 putative NAD binding site [chemical binding]; other site 264731001870 catalytic site [active] 264731001871 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 264731001872 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 264731001873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001875 ABC transporter; Region: ABC_tran_2; pfam12848 264731001876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731001877 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731001878 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731001879 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731001880 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 264731001881 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731001882 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731001883 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731001884 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 264731001885 uracil transporter; Provisional; Region: PRK10720 264731001886 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264731001887 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264731001888 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264731001889 G1 box; other site 264731001890 GTP/Mg2+ binding site [chemical binding]; other site 264731001891 Switch I region; other site 264731001892 G2 box; other site 264731001893 Switch II region; other site 264731001894 G3 box; other site 264731001895 G4 box; other site 264731001896 G5 box; other site 264731001897 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264731001898 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 264731001899 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264731001900 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 264731001901 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264731001902 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 264731001903 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 264731001904 FAD binding pocket [chemical binding]; other site 264731001905 FAD binding motif [chemical binding]; other site 264731001906 phosphate binding motif [ion binding]; other site 264731001907 beta-alpha-beta structure motif; other site 264731001908 NAD binding pocket [chemical binding]; other site 264731001909 Iron coordination center [ion binding]; other site 264731001910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731001911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264731001912 seryl-tRNA synthetase; Provisional; Region: PRK05431 264731001913 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264731001914 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264731001915 dimer interface [polypeptide binding]; other site 264731001916 active site 264731001917 motif 1; other site 264731001918 motif 2; other site 264731001919 motif 3; other site 264731001920 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264731001921 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264731001922 PIF1-like helicase; Region: PIF1; pfam05970 264731001923 AAA domain; Region: AAA_30; pfam13604 264731001924 Transglycosylase; Region: Transgly; pfam00912 264731001925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264731001926 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264731001927 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264731001928 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264731001929 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264731001930 active site 264731001931 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 264731001932 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 264731001933 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264731001934 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264731001935 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 264731001936 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264731001937 trimer interface [polypeptide binding]; other site 264731001938 active site 264731001939 UDP-GlcNAc binding site [chemical binding]; other site 264731001940 lipid binding site [chemical binding]; lipid-binding site 264731001941 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 264731001942 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731001943 Zn2+ binding site [ion binding]; other site 264731001944 Mg2+ binding site [ion binding]; other site 264731001945 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 264731001946 active site 264731001947 dimer interface [polypeptide binding]; other site 264731001948 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264731001949 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264731001950 RF-1 domain; Region: RF-1; pfam00472 264731001951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731001952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731001953 dimer interface [polypeptide binding]; other site 264731001954 phosphorylation site [posttranslational modification] 264731001955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731001956 ATP binding site [chemical binding]; other site 264731001957 Mg2+ binding site [ion binding]; other site 264731001958 G-X-G motif; other site 264731001959 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 264731001960 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 264731001961 putative active site [active] 264731001962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264731001963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731001964 Walker A/P-loop; other site 264731001965 ATP binding site [chemical binding]; other site 264731001966 Q-loop/lid; other site 264731001967 ABC transporter signature motif; other site 264731001968 Walker B; other site 264731001969 D-loop; other site 264731001970 H-loop/switch region; other site 264731001971 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264731001972 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731001973 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731001974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731001975 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 264731001976 active site 264731001977 metal binding site [ion binding]; metal-binding site 264731001978 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 264731001979 dimerization interface [polypeptide binding]; other site 264731001980 ATP binding site [chemical binding]; other site 264731001981 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264731001982 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264731001983 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264731001984 shikimate binding site; other site 264731001985 NAD(P) binding site [chemical binding]; other site 264731001986 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264731001987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731001988 S-adenosylmethionine binding site [chemical binding]; other site 264731001989 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 264731001990 ATP binding site [chemical binding]; other site 264731001991 active site 264731001992 substrate binding site [chemical binding]; other site 264731001993 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264731001994 PhoH-like protein; Region: PhoH; pfam02562 264731001995 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 264731001996 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264731001997 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 264731001998 active site 264731001999 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 264731002000 2-isopropylmalate synthase; Validated; Region: PRK00915 264731002001 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 264731002002 active site 264731002003 catalytic residues [active] 264731002004 metal binding site [ion binding]; metal-binding site 264731002005 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 264731002006 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264731002007 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264731002008 substrate binding site [chemical binding]; other site 264731002009 ligand binding site [chemical binding]; other site 264731002010 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 264731002011 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264731002012 substrate binding site [chemical binding]; other site 264731002013 (R)-citramalate synthase; Provisional; Region: PRK09389 264731002014 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264731002015 active site 264731002016 catalytic residues [active] 264731002017 metal binding site [ion binding]; metal-binding site 264731002018 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 264731002019 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 264731002020 tartrate dehydrogenase; Region: TTC; TIGR02089 264731002021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002022 binding surface 264731002023 TPR motif; other site 264731002024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002025 binding surface 264731002026 TPR motif; other site 264731002027 TPR repeat; Region: TPR_11; pfam13414 264731002028 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 264731002029 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 264731002030 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 264731002031 mannonate dehydratase; Provisional; Region: PRK03906 264731002032 mannonate dehydratase; Region: uxuA; TIGR00695 264731002033 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 264731002034 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 264731002035 Carbon starvation protein CstA; Region: CstA; pfam02554 264731002036 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 264731002037 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 264731002038 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264731002039 dimerization interface [polypeptide binding]; other site 264731002040 active site 264731002041 Peptidase family C69; Region: Peptidase_C69; cl17793 264731002042 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264731002043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731002044 motif II; other site 264731002045 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 264731002046 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264731002047 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264731002048 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264731002049 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264731002050 active site 264731002051 UGMP family protein; Validated; Region: PRK09604 264731002052 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264731002053 Competence-damaged protein; Region: CinA; pfam02464 264731002054 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 264731002055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 264731002056 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 264731002057 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264731002058 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 264731002059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264731002060 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 264731002061 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264731002062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731002063 FeS/SAM binding site; other site 264731002064 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264731002065 IHF dimer interface [polypeptide binding]; other site 264731002066 IHF - DNA interface [nucleotide binding]; other site 264731002067 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264731002068 IHF - DNA interface [nucleotide binding]; other site 264731002069 IHF dimer interface [polypeptide binding]; other site 264731002070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 264731002071 MoxR-like ATPases [General function prediction only]; Region: COG0714 264731002072 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 264731002073 ATP binding site [chemical binding]; other site 264731002074 Walker A motif; other site 264731002075 Walker B motif; other site 264731002076 arginine finger; other site 264731002077 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264731002078 Protein of unknown function DUF58; Region: DUF58; pfam01882 264731002079 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 264731002080 metal ion-dependent adhesion site (MIDAS); other site 264731002081 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 264731002082 metal ion-dependent adhesion site (MIDAS); other site 264731002083 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 264731002084 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264731002085 metal ion-dependent adhesion site (MIDAS); other site 264731002086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002087 binding surface 264731002088 TPR motif; other site 264731002089 TPR repeat; Region: TPR_11; pfam13414 264731002090 Oxygen tolerance; Region: BatD; pfam13584 264731002091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002092 TPR motif; other site 264731002093 TPR repeat; Region: TPR_11; pfam13414 264731002094 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 264731002095 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264731002096 active site 264731002097 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 264731002098 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 264731002099 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264731002100 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 264731002101 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 264731002102 metal binding site [ion binding]; metal-binding site 264731002103 dimer interface [polypeptide binding]; other site 264731002104 WYL domain; Region: WYL; pfam13280 264731002105 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 264731002106 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 264731002107 hypothetical protein; Provisional; Region: PRK10236 264731002108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 264731002109 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264731002110 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731002111 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 264731002112 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 264731002113 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 264731002114 hypothetical protein; Provisional; Region: PRK00955 264731002115 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 264731002116 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 264731002117 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 264731002118 active site 264731002119 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264731002120 Interdomain contacts; other site 264731002121 Cytokine receptor motif; other site 264731002122 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264731002123 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 264731002124 putative acyl-acceptor binding pocket; other site 264731002125 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 264731002126 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 264731002127 active site 264731002128 ADP/pyrophosphate binding site [chemical binding]; other site 264731002129 dimerization interface [polypeptide binding]; other site 264731002130 allosteric effector site; other site 264731002131 fructose-1,6-bisphosphate binding site; other site 264731002132 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 264731002133 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 264731002134 active site 264731002135 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264731002136 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 264731002137 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264731002138 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 264731002139 Surface antigen; Region: Bac_surface_Ag; pfam01103 264731002140 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264731002141 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 264731002142 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264731002143 SmpB-tmRNA interface; other site 264731002144 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 264731002145 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 264731002146 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 264731002147 substrate binding pocket [chemical binding]; other site 264731002148 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 264731002149 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 264731002150 B12 binding site [chemical binding]; other site 264731002151 cobalt ligand [ion binding]; other site 264731002152 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 264731002153 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 264731002154 Putative Fe-S cluster; Region: FeS; cl17515 264731002155 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731002156 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264731002157 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731002158 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264731002159 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264731002160 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 264731002161 SLBB domain; Region: SLBB; pfam10531 264731002162 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264731002163 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 264731002164 FMN-binding domain; Region: FMN_bind; cl01081 264731002165 electron transport complex RsxE subunit; Provisional; Region: PRK12405 264731002166 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 264731002167 Domain of unknown function (DUF2027); Region: DUF2027; pfam09640 264731002168 NAD synthetase; Reviewed; Region: nadE; PRK02628 264731002169 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 264731002170 multimer interface [polypeptide binding]; other site 264731002171 active site 264731002172 catalytic triad [active] 264731002173 protein interface 1 [polypeptide binding]; other site 264731002174 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264731002175 homodimer interface [polypeptide binding]; other site 264731002176 NAD binding pocket [chemical binding]; other site 264731002177 ATP binding pocket [chemical binding]; other site 264731002178 Mg binding site [ion binding]; other site 264731002179 active-site loop [active] 264731002180 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264731002181 Clp amino terminal domain; Region: Clp_N; pfam02861 264731002182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731002183 Walker A motif; other site 264731002184 ATP binding site [chemical binding]; other site 264731002185 Walker B motif; other site 264731002186 arginine finger; other site 264731002187 UvrB/uvrC motif; Region: UVR; pfam02151 264731002188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731002189 Walker A motif; other site 264731002190 ATP binding site [chemical binding]; other site 264731002191 Walker B motif; other site 264731002192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264731002193 DNA gyrase subunit A; Validated; Region: PRK05560 264731002194 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264731002195 CAP-like domain; other site 264731002196 active site 264731002197 primary dimer interface [polypeptide binding]; other site 264731002198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002199 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002200 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002201 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002202 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002203 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264731002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002205 binding surface 264731002206 TPR motif; other site 264731002207 TPR repeat; Region: TPR_11; pfam13414 264731002208 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731002209 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264731002210 anti sigma factor interaction site; other site 264731002211 regulatory phosphorylation site [posttranslational modification]; other site 264731002212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264731002213 active site 264731002214 ATP binding site [chemical binding]; other site 264731002215 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 264731002216 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264731002217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264731002218 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 264731002219 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264731002220 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264731002221 putative tRNA-binding site [nucleotide binding]; other site 264731002222 B3/4 domain; Region: B3_4; pfam03483 264731002223 tRNA synthetase B5 domain; Region: B5; pfam03484 264731002224 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264731002225 dimer interface [polypeptide binding]; other site 264731002226 motif 1; other site 264731002227 motif 3; other site 264731002228 motif 2; other site 264731002229 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 264731002230 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 264731002231 four helix bundle protein; Region: TIGR02436 264731002232 hypothetical protein; Provisional; Region: PRK12378 264731002233 GTP-binding protein LepA; Provisional; Region: PRK05433 264731002234 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264731002235 G1 box; other site 264731002236 putative GEF interaction site [polypeptide binding]; other site 264731002237 GTP/Mg2+ binding site [chemical binding]; other site 264731002238 Switch I region; other site 264731002239 G2 box; other site 264731002240 G3 box; other site 264731002241 Switch II region; other site 264731002242 G4 box; other site 264731002243 G5 box; other site 264731002244 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264731002245 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264731002246 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264731002247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264731002248 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264731002249 ligand binding site [chemical binding]; other site 264731002250 flexible hinge region; other site 264731002251 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264731002252 active site 264731002253 putative DNA-binding cleft [nucleotide binding]; other site 264731002254 dimer interface [polypeptide binding]; other site 264731002255 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 264731002256 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 264731002257 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 264731002258 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 264731002259 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 264731002260 recombination factor protein RarA; Reviewed; Region: PRK13342 264731002261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731002262 Walker A motif; other site 264731002263 ATP binding site [chemical binding]; other site 264731002264 Walker B motif; other site 264731002265 arginine finger; other site 264731002266 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264731002267 Predicted membrane protein [Function unknown]; Region: COG2860 264731002268 UPF0126 domain; Region: UPF0126; pfam03458 264731002269 UPF0126 domain; Region: UPF0126; pfam03458 264731002270 replicative DNA helicase; Region: DnaB; TIGR00665 264731002271 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264731002272 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264731002273 Walker A motif; other site 264731002274 ATP binding site [chemical binding]; other site 264731002275 Walker B motif; other site 264731002276 DNA binding loops [nucleotide binding] 264731002277 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264731002278 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264731002279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002280 TPR motif; other site 264731002281 binding surface 264731002282 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264731002283 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264731002284 Walker A/P-loop; other site 264731002285 ATP binding site [chemical binding]; other site 264731002286 Q-loop/lid; other site 264731002287 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264731002288 ABC transporter signature motif; other site 264731002289 Walker B; other site 264731002290 D-loop; other site 264731002291 H-loop/switch region; other site 264731002292 exodeoxyribonuclease X; Provisional; Region: PRK07983 264731002293 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264731002294 active site 264731002295 catalytic site [active] 264731002296 substrate binding site [chemical binding]; other site 264731002297 DNA polymerase III subunit beta; Validated; Region: PRK05643 264731002298 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264731002299 putative DNA binding surface [nucleotide binding]; other site 264731002300 dimer interface [polypeptide binding]; other site 264731002301 beta-clamp/clamp loader binding surface; other site 264731002302 beta-clamp/translesion DNA polymerase binding surface; other site 264731002303 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 264731002304 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 264731002305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731002306 S-adenosylmethionine binding site [chemical binding]; other site 264731002307 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264731002308 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264731002309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731002310 Walker A motif; other site 264731002311 ATP binding site [chemical binding]; other site 264731002312 Walker B motif; other site 264731002313 arginine finger; other site 264731002314 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264731002315 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 264731002316 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264731002317 Predicted permeases [General function prediction only]; Region: COG0795 264731002318 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264731002319 helicase 45; Provisional; Region: PTZ00424 264731002320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264731002321 ATP binding site [chemical binding]; other site 264731002322 Mg++ binding site [ion binding]; other site 264731002323 motif III; other site 264731002324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731002325 nucleotide binding region [chemical binding]; other site 264731002326 ATP-binding site [chemical binding]; other site 264731002327 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 264731002328 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264731002329 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264731002330 UDP-glucose 4-epimerase; Region: PLN02240 264731002331 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264731002332 NAD binding site [chemical binding]; other site 264731002333 homodimer interface [polypeptide binding]; other site 264731002334 active site 264731002335 substrate binding site [chemical binding]; other site 264731002336 NMT1/THI5 like; Region: NMT1; pfam09084 264731002337 Cache domain; Region: Cache_1; pfam02743 264731002338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731002339 dimerization interface [polypeptide binding]; other site 264731002340 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731002341 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731002342 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264731002343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731002344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731002345 dimer interface [polypeptide binding]; other site 264731002346 phosphorylation site [posttranslational modification] 264731002347 Prolamin-like; Region: Prolamin_like; cl05275 264731002348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731002349 ATP binding site [chemical binding]; other site 264731002350 Mg2+ binding site [ion binding]; other site 264731002351 G-X-G motif; other site 264731002352 virion protein; Provisional; Region: V; PHA02564 264731002353 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264731002354 active site 264731002355 metal binding site [ion binding]; metal-binding site 264731002356 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 264731002357 SurA N-terminal domain; Region: SurA_N_2; pfam13623 264731002358 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 264731002359 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 264731002360 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264731002361 Domain of unknown function DUF21; Region: DUF21; pfam01595 264731002362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264731002363 Transporter associated domain; Region: CorC_HlyC; smart01091 264731002364 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 264731002365 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264731002366 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 264731002367 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 264731002368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 264731002369 nucleotide binding region [chemical binding]; other site 264731002370 ATP-binding site [chemical binding]; other site 264731002371 SEC-C motif; Region: SEC-C; pfam02810 264731002372 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264731002373 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264731002374 Walker A/P-loop; other site 264731002375 ATP binding site [chemical binding]; other site 264731002376 Q-loop/lid; other site 264731002377 ABC transporter signature motif; other site 264731002378 Walker B; other site 264731002379 D-loop; other site 264731002380 H-loop/switch region; other site 264731002381 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 264731002382 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264731002383 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264731002384 G1 box; other site 264731002385 GTP/Mg2+ binding site [chemical binding]; other site 264731002386 Switch I region; other site 264731002387 G2 box; other site 264731002388 G3 box; other site 264731002389 Switch II region; other site 264731002390 G4 box; other site 264731002391 G5 box; other site 264731002392 Nucleoside recognition; Region: Gate; pfam07670 264731002393 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264731002394 Nucleoside recognition; Region: Gate; pfam07670 264731002395 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731002396 active site 264731002397 AbgT putative transporter family; Region: ABG_transport; cl17431 264731002398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264731002399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 264731002400 active site 264731002401 phosphorylation site [posttranslational modification] 264731002402 intermolecular recognition site; other site 264731002403 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731002404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731002406 ATP binding site [chemical binding]; other site 264731002407 Mg2+ binding site [ion binding]; other site 264731002408 G-X-G motif; other site 264731002409 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 264731002410 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264731002411 active site 264731002412 intersubunit interface [polypeptide binding]; other site 264731002413 catalytic residue [active] 264731002414 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264731002415 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264731002416 substrate binding site [chemical binding]; other site 264731002417 ATP binding site [chemical binding]; other site 264731002418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264731002419 DNA binding site [nucleotide binding] 264731002420 domain linker motif; other site 264731002421 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264731002422 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264731002423 ligand binding site [chemical binding]; other site 264731002424 galactarate dehydratase; Region: galactar-dH20; TIGR03248 264731002425 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264731002426 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264731002427 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 264731002428 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 264731002429 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 264731002430 active site 264731002431 Clostripain family; Region: Peptidase_C11; pfam03415 264731002432 gliding motility-associated protein GldE; Region: GldE; TIGR03520 264731002433 Domain of unknown function DUF21; Region: DUF21; pfam01595 264731002434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264731002435 Transporter associated domain; Region: CorC_HlyC; smart01091 264731002436 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264731002437 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264731002438 dimer interface [polypeptide binding]; other site 264731002439 ssDNA binding site [nucleotide binding]; other site 264731002440 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264731002441 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 264731002442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 264731002443 dimer interface [polypeptide binding]; other site 264731002444 active site 264731002445 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264731002446 catalytic residues [active] 264731002447 substrate binding site [chemical binding]; other site 264731002448 Response regulator receiver domain; Region: Response_reg; pfam00072 264731002449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731002450 active site 264731002451 phosphorylation site [posttranslational modification] 264731002452 intermolecular recognition site; other site 264731002453 dimerization interface [polypeptide binding]; other site 264731002454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731002455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731002456 dimer interface [polypeptide binding]; other site 264731002457 phosphorylation site [posttranslational modification] 264731002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731002459 ATP binding site [chemical binding]; other site 264731002460 Mg2+ binding site [ion binding]; other site 264731002461 G-X-G motif; other site 264731002462 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 264731002463 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264731002464 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264731002465 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264731002466 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264731002467 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264731002468 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 264731002469 probable substrate binding site [chemical binding]; other site 264731002470 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264731002471 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264731002472 glutaminase active site [active] 264731002473 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264731002474 dimer interface [polypeptide binding]; other site 264731002475 active site 264731002476 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264731002477 dimer interface [polypeptide binding]; other site 264731002478 active site 264731002479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264731002480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731002481 Coenzyme A binding pocket [chemical binding]; other site 264731002482 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264731002483 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264731002484 Probable Catalytic site; other site 264731002485 metal-binding site 264731002486 recombination protein RecR; Reviewed; Region: recR; PRK00076 264731002487 RecR protein; Region: RecR; pfam02132 264731002488 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264731002489 putative active site [active] 264731002490 putative metal-binding site [ion binding]; other site 264731002491 tetramer interface [polypeptide binding]; other site 264731002492 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264731002493 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731002494 ABC transporter; Region: ABC_tran_2; pfam12848 264731002495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264731002496 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264731002497 G1 box; other site 264731002498 GTP/Mg2+ binding site [chemical binding]; other site 264731002499 Switch I region; other site 264731002500 G2 box; other site 264731002501 G3 box; other site 264731002502 Switch II region; other site 264731002503 G4 box; other site 264731002504 G5 box; other site 264731002505 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 264731002506 transcription termination factor Rho; Provisional; Region: PRK12608 264731002507 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264731002508 RNA binding site [nucleotide binding]; other site 264731002509 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264731002510 multimer interface [polypeptide binding]; other site 264731002511 Walker A motif; other site 264731002512 ATP binding site [chemical binding]; other site 264731002513 Walker B motif; other site 264731002514 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 264731002515 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264731002516 active site 264731002517 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 264731002518 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264731002519 Ligand Binding Site [chemical binding]; other site 264731002520 TilS substrate C-terminal domain; Region: TilS_C; smart00977 264731002521 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 264731002522 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264731002523 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264731002524 putative RNA binding site [nucleotide binding]; other site 264731002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731002526 S-adenosylmethionine binding site [chemical binding]; other site 264731002527 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 264731002528 catalytic site [active] 264731002529 putative active site [active] 264731002530 putative substrate binding site [chemical binding]; other site 264731002531 prophage PRU01; lysogenic prophage region. attL/R=tgcaaaattataaaataaat. 264731002532 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264731002533 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 264731002534 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264731002535 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 264731002536 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 264731002537 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264731002538 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264731002539 active site 264731002540 DNA binding site [nucleotide binding] 264731002541 Int/Topo IB signature motif; other site 264731002542 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 264731002543 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731002544 amidase catalytic site [active] 264731002545 Zn binding residues [ion binding]; other site 264731002546 substrate binding site [chemical binding]; other site 264731002547 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 264731002548 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264731002549 Catalytic site [active] 264731002550 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 264731002551 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264731002552 active site 264731002553 DNA binding site [nucleotide binding] 264731002554 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264731002555 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 264731002556 WYL domain; Region: WYL; pfam13280 264731002557 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 264731002558 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731002559 hypothetical protein; Region: PHA00684 264731002560 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264731002561 metal ion-dependent adhesion site (MIDAS); other site 264731002562 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 264731002563 HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556 264731002564 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264731002565 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 264731002566 cofactor binding site; other site 264731002567 DNA binding site [nucleotide binding] 264731002568 substrate interaction site [chemical binding]; other site 264731002569 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 264731002570 WYL domain; Region: WYL; pfam13280 264731002571 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 264731002572 oligomer interface [polypeptide binding]; other site 264731002573 active site residues [active] 264731002574 Septum formation initiator; Region: DivIC; cl17659 264731002575 DKNYY family; Region: DKNYY; pfam13644 264731002576 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264731002577 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 264731002578 DNA primase, catalytic core; Region: dnaG; TIGR01391 264731002579 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264731002580 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264731002581 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264731002582 active site 264731002583 metal binding site [ion binding]; metal-binding site 264731002584 interdomain interaction site; other site 264731002585 Helix-turn-helix domain; Region: HTH_17; cl17695 264731002586 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 264731002587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731002588 non-specific DNA binding site [nucleotide binding]; other site 264731002589 salt bridge; other site 264731002590 sequence-specific DNA binding site [nucleotide binding]; other site 264731002591 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264731002592 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264731002593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731002594 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731002595 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 264731002596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731002597 motif II; other site 264731002598 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 264731002599 putative FMN binding site [chemical binding]; other site 264731002600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 264731002601 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264731002602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264731002603 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264731002604 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264731002605 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731002606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731002607 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 264731002608 active site 264731002609 metal binding site [ion binding]; metal-binding site 264731002610 substrate binding site [chemical binding]; other site 264731002611 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 264731002612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 264731002613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264731002614 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 264731002615 active site 264731002616 catalytic motif [active] 264731002617 Zn binding site [ion binding]; other site 264731002618 Right handed beta helix region; Region: Beta_helix; pfam13229 264731002619 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 264731002620 Rubredoxin; Region: Rubredoxin; pfam00301 264731002621 iron binding site [ion binding]; other site 264731002622 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 264731002623 Rubrerythrin [Energy production and conversion]; Region: COG1592 264731002624 diiron binding motif [ion binding]; other site 264731002625 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 264731002626 active site 264731002627 catalytic triad [active] 264731002628 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264731002629 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264731002630 dimer interface [polypeptide binding]; other site 264731002631 motif 1; other site 264731002632 active site 264731002633 motif 2; other site 264731002634 motif 3; other site 264731002635 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264731002636 anticodon binding site; other site 264731002637 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 264731002638 four helix bundle protein; Region: TIGR02436 264731002639 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264731002640 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264731002641 GDP-binding site [chemical binding]; other site 264731002642 ACT binding site; other site 264731002643 IMP binding site; other site 264731002644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264731002645 metal binding site 2 [ion binding]; metal-binding site 264731002646 putative DNA binding helix; other site 264731002647 metal binding site 1 [ion binding]; metal-binding site 264731002648 dimer interface [polypeptide binding]; other site 264731002649 structural Zn2+ binding site [ion binding]; other site 264731002650 A new structural DNA glycosylase; Region: AlkD_like; cd06561 264731002651 active site 264731002652 Peptidase family M49; Region: Peptidase_M49; pfam03571 264731002653 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731002654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731002655 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 264731002656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731002657 ATP binding site [chemical binding]; other site 264731002658 putative Mg++ binding site [ion binding]; other site 264731002659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731002660 nucleotide binding region [chemical binding]; other site 264731002661 ATP-binding site [chemical binding]; other site 264731002662 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 264731002663 HRDC domain; Region: HRDC; pfam00570 264731002664 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 264731002665 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 264731002666 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264731002667 Part of AAA domain; Region: AAA_19; pfam13245 264731002668 Family description; Region: UvrD_C_2; pfam13538 264731002669 BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative...; Region: BPI; cl00188 264731002670 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 264731002671 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 264731002672 Abi-like protein; Region: Abi_2; pfam07751 264731002673 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264731002674 DNA methylase; Region: N6_N4_Mtase; pfam01555 264731002675 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264731002676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731002677 ATP binding site [chemical binding]; other site 264731002678 putative Mg++ binding site [ion binding]; other site 264731002679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731002680 nucleotide binding region [chemical binding]; other site 264731002681 ATP-binding site [chemical binding]; other site 264731002682 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 264731002683 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 264731002684 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264731002685 Divergent AAA domain; Region: AAA_4; pfam04326 264731002686 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264731002687 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 264731002688 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731002689 Clostripain family; Region: Peptidase_C11; pfam03415 264731002690 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264731002691 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264731002692 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731002693 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731002694 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731002695 catalytic residues [active] 264731002696 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 264731002697 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 264731002698 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 264731002699 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 264731002700 putative catalytic residues [active] 264731002701 putative nucleotide binding site [chemical binding]; other site 264731002702 putative aspartate binding site [chemical binding]; other site 264731002703 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 264731002704 dimer interface [polypeptide binding]; other site 264731002705 putative threonine allosteric regulatory site; other site 264731002706 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 264731002707 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 264731002708 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264731002709 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 264731002710 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 264731002711 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 264731002712 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 264731002713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731002714 catalytic residue [active] 264731002715 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 264731002716 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264731002717 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264731002718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264731002719 protein binding site [polypeptide binding]; other site 264731002720 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264731002721 protein binding site [polypeptide binding]; other site 264731002722 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264731002723 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 264731002724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731002725 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264731002726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731002727 DNA binding residues [nucleotide binding] 264731002728 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731002729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731002730 homodimer interface [polypeptide binding]; other site 264731002731 catalytic residue [active] 264731002732 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 264731002733 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 264731002734 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 264731002735 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264731002736 dimer interface [polypeptide binding]; other site 264731002737 PYR/PP interface [polypeptide binding]; other site 264731002738 TPP binding site [chemical binding]; other site 264731002739 substrate binding site [chemical binding]; other site 264731002740 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264731002741 TPP-binding site; other site 264731002742 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 264731002743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731002744 S-adenosylmethionine binding site [chemical binding]; other site 264731002745 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 264731002746 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264731002747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264731002748 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264731002749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264731002750 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264731002751 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 264731002752 probable substrate binding site [chemical binding]; other site 264731002753 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264731002754 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264731002755 TSCPD domain; Region: TSCPD; cl14834 264731002756 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 264731002757 Uncharacterized conserved protein [Function unknown]; Region: COG4198 264731002758 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 264731002759 nucleotide binding site/active site [active] 264731002760 HIT family signature motif; other site 264731002761 catalytic residue [active] 264731002762 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 264731002763 NAD binding site [chemical binding]; other site 264731002764 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 264731002765 four helix bundle protein; Region: TIGR02436 264731002766 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 264731002767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731002768 catalytic residue [active] 264731002769 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 264731002770 catalytic center binding site [active] 264731002771 ATP binding site [chemical binding]; other site 264731002772 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 264731002773 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264731002774 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264731002775 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 264731002776 Transglycosylase; Region: Transgly; cl17702 264731002777 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264731002778 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264731002779 ligand binding site [chemical binding]; other site 264731002780 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264731002781 active site 264731002782 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 264731002783 BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative...; Region: BPI; cl00188 264731002784 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 264731002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731002786 AAA domain; Region: AAA_23; pfam13476 264731002787 Walker A/P-loop; other site 264731002788 ATP binding site [chemical binding]; other site 264731002789 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264731002790 putative active site [active] 264731002791 catalytic site [active] 264731002792 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 264731002793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731002794 ATP binding site [chemical binding]; other site 264731002795 putative Mg++ binding site [ion binding]; other site 264731002796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731002797 nucleotide binding region [chemical binding]; other site 264731002798 ATP-binding site [chemical binding]; other site 264731002799 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264731002800 Ligand Binding Site [chemical binding]; other site 264731002801 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 264731002802 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264731002803 Divergent AAA domain; Region: AAA_4; pfam04326 264731002804 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264731002805 HTH domain; Region: HTH_11; pfam08279 264731002806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731002807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 264731002808 active site 264731002809 metal binding site [ion binding]; metal-binding site 264731002810 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731002811 prolyl-tRNA synthetase; Provisional; Region: PRK08661 264731002812 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 264731002813 dimer interface [polypeptide binding]; other site 264731002814 motif 1; other site 264731002815 active site 264731002816 motif 2; other site 264731002817 motif 3; other site 264731002818 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 264731002819 anticodon binding site; other site 264731002820 zinc-binding site [ion binding]; other site 264731002821 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 264731002822 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264731002823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731002824 acyl-activating enzyme (AAE) consensus motif; other site 264731002825 AMP binding site [chemical binding]; other site 264731002826 active site 264731002827 CoA binding site [chemical binding]; other site 264731002828 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 264731002829 nucleoside transporter; Region: 2A0110; TIGR00889 264731002830 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 264731002831 lipoprotein signal peptidase; Provisional; Region: PRK14788 264731002832 lipoprotein signal peptidase; Provisional; Region: PRK14787 264731002833 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264731002834 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 264731002835 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731002836 active site 264731002837 HIGH motif; other site 264731002838 nucleotide binding site [chemical binding]; other site 264731002839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731002840 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731002841 active site 264731002842 KMSKS motif; other site 264731002843 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 264731002844 tRNA binding surface [nucleotide binding]; other site 264731002845 anticodon binding site; other site 264731002846 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 264731002847 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 264731002848 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 264731002849 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 264731002850 active site 264731002851 substrate binding site [chemical binding]; other site 264731002852 metal binding site [ion binding]; metal-binding site 264731002853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731002854 binding surface 264731002855 TPR motif; other site 264731002856 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264731002857 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 264731002858 active site 264731002859 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264731002860 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264731002861 putative valine binding site [chemical binding]; other site 264731002862 dimer interface [polypeptide binding]; other site 264731002863 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264731002864 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 264731002865 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264731002866 PYR/PP interface [polypeptide binding]; other site 264731002867 dimer interface [polypeptide binding]; other site 264731002868 TPP binding site [chemical binding]; other site 264731002869 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264731002870 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264731002871 TPP-binding site [chemical binding]; other site 264731002872 dimer interface [polypeptide binding]; other site 264731002873 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 264731002874 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731002875 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731002876 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731002877 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 264731002878 cobyric acid synthase; Provisional; Region: PRK00784 264731002879 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 264731002880 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264731002881 catalytic triad [active] 264731002882 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 264731002883 active site 264731002884 SAM binding site [chemical binding]; other site 264731002885 homodimer interface [polypeptide binding]; other site 264731002886 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 264731002887 Precorrin-8X methylmutase; Region: CbiC; pfam02570 264731002888 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 264731002889 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731002890 N-terminal plug; other site 264731002891 ligand-binding site [chemical binding]; other site 264731002892 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 264731002893 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 264731002894 active site 264731002895 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 264731002896 active site 264731002897 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 264731002898 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731002899 N-terminal plug; other site 264731002900 ligand-binding site [chemical binding]; other site 264731002901 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 264731002902 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 264731002903 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 264731002904 catalytic triad [active] 264731002905 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 264731002906 active site 264731002907 putative homodimer interface [polypeptide binding]; other site 264731002908 SAM binding site [chemical binding]; other site 264731002909 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 264731002910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731002911 S-adenosylmethionine binding site [chemical binding]; other site 264731002912 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 264731002913 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 264731002914 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 264731002915 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 264731002916 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 264731002917 active site 264731002918 SAM binding site [chemical binding]; other site 264731002919 homodimer interface [polypeptide binding]; other site 264731002920 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 264731002921 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 264731002922 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264731002923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264731002924 ABC-ATPase subunit interface; other site 264731002925 dimer interface [polypeptide binding]; other site 264731002926 putative PBP binding regions; other site 264731002927 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264731002928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264731002929 intersubunit interface [polypeptide binding]; other site 264731002930 cobalamin synthase; Reviewed; Region: cobS; PRK00235 264731002931 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 264731002932 homotrimer interface [polypeptide binding]; other site 264731002933 Walker A motif; other site 264731002934 GTP binding site [chemical binding]; other site 264731002935 Walker B motif; other site 264731002936 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 264731002937 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264731002938 putative dimer interface [polypeptide binding]; other site 264731002939 active site pocket [active] 264731002940 putative cataytic base [active] 264731002941 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731002942 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 264731002943 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731002944 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264731002945 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264731002946 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264731002947 protein binding site [polypeptide binding]; other site 264731002948 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 264731002949 Domain interface; other site 264731002950 Peptide binding site; other site 264731002951 Active site tetrad [active] 264731002952 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 264731002953 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 264731002954 active site 264731002955 Rubrerythrin [Energy production and conversion]; Region: COG1592 264731002956 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264731002957 dinuclear metal binding motif [ion binding]; other site 264731002958 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 264731002959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731002960 FeS/SAM binding site; other site 264731002961 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 264731002962 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 264731002963 protein binding site [polypeptide binding]; other site 264731002964 putative pectinesterase; Region: PLN02432; cl01911 264731002965 enolase; Provisional; Region: eno; PRK00077 264731002966 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264731002967 dimer interface [polypeptide binding]; other site 264731002968 metal binding site [ion binding]; metal-binding site 264731002969 substrate binding pocket [chemical binding]; other site 264731002970 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 264731002971 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731002972 N-terminal plug; other site 264731002973 ligand-binding site [chemical binding]; other site 264731002974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731002975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731002976 dimer interface [polypeptide binding]; other site 264731002977 phosphorylation site [posttranslational modification] 264731002978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731002979 ATP binding site [chemical binding]; other site 264731002980 Mg2+ binding site [ion binding]; other site 264731002981 G-X-G motif; other site 264731002982 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 264731002983 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264731002984 Int/Topo IB signature motif; other site 264731002985 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 264731002986 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264731002987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731002988 putative Mg++ binding site [ion binding]; other site 264731002989 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 264731002990 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264731002991 Helix-turn-helix domain; Region: HTH_17; pfam12728 264731002992 Helix-turn-helix domain; Region: HTH_17; pfam12728 264731002993 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 264731002994 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 264731002995 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 264731002996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731002997 FeS/SAM binding site; other site 264731002998 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264731002999 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731003000 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731003001 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731003002 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264731003003 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264731003004 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731003005 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 264731003006 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 264731003007 putative active site [active] 264731003008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264731003009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731003010 Walker A/P-loop; other site 264731003011 ATP binding site [chemical binding]; other site 264731003012 Q-loop/lid; other site 264731003013 ABC transporter signature motif; other site 264731003014 Walker B; other site 264731003015 D-loop; other site 264731003016 H-loop/switch region; other site 264731003017 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 264731003018 putative active site [active] 264731003019 redox center [active] 264731003020 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 264731003021 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 264731003022 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264731003023 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264731003024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264731003025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731003026 Coenzyme A binding pocket [chemical binding]; other site 264731003027 Predicted permeases [General function prediction only]; Region: COG0701 264731003028 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264731003029 metal-binding site [ion binding] 264731003030 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264731003031 Cation efflux family; Region: Cation_efflux; pfam01545 264731003032 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 264731003033 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264731003034 putative trimer interface [polypeptide binding]; other site 264731003035 putative CoA binding site [chemical binding]; other site 264731003036 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731003037 amidase catalytic site [active] 264731003038 Zn binding residues [ion binding]; other site 264731003039 substrate binding site [chemical binding]; other site 264731003040 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731003041 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 264731003042 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 264731003043 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 264731003044 VirE N-terminal domain; Region: VirE_N; pfam08800 264731003045 Virulence-associated protein E; Region: VirE; pfam05272 264731003046 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 264731003047 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264731003048 Divergent AAA domain; Region: AAA_4; pfam04326 264731003049 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731003050 active site 264731003051 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264731003052 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 264731003053 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264731003054 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264731003055 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264731003056 active site 264731003057 dimerization interface [polypeptide binding]; other site 264731003058 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264731003059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731003060 Zn2+ binding site [ion binding]; other site 264731003061 Mg2+ binding site [ion binding]; other site 264731003062 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 264731003063 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 264731003064 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 264731003065 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264731003066 dimer interface [polypeptide binding]; other site 264731003067 PYR/PP interface [polypeptide binding]; other site 264731003068 TPP binding site [chemical binding]; other site 264731003069 substrate binding site [chemical binding]; other site 264731003070 Ferredoxin [Energy production and conversion]; Region: COG1146 264731003071 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264731003072 TPR repeat; Region: TPR_11; pfam13414 264731003073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731003074 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 264731003075 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264731003076 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264731003077 homodimer interface [polypeptide binding]; other site 264731003078 NADP binding site [chemical binding]; other site 264731003079 substrate binding site [chemical binding]; other site 264731003080 signal recognition particle protein; Provisional; Region: PRK10867 264731003081 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264731003082 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264731003083 P loop; other site 264731003084 GTP binding site [chemical binding]; other site 264731003085 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264731003086 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 264731003087 Ligand Binding Site [chemical binding]; other site 264731003088 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 264731003089 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 264731003090 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 264731003091 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 264731003092 active site 264731003093 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 264731003094 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 264731003095 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 264731003096 active site 264731003097 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 264731003098 PA14 domain; Region: PA14; pfam07691 264731003099 Uncharacterized conserved protein [Function unknown]; Region: COG3538 264731003100 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 264731003101 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731003102 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731003103 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731003104 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731003105 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731003106 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731003107 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 264731003108 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731003109 Glyco_18 domain; Region: Glyco_18; smart00636 264731003110 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 264731003111 active site 264731003112 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 264731003113 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 264731003114 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731003115 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731003116 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731003117 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731003118 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 264731003119 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 264731003120 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731003121 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731003122 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 264731003123 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 264731003124 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731003125 sugar binding site [chemical binding]; other site 264731003126 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731003127 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264731003128 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731003129 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731003130 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731003131 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731003132 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 264731003133 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264731003134 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264731003135 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 264731003136 prephenate dehydrogenase; Validated; Region: PRK08507 264731003137 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264731003138 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 264731003139 Chorismate mutase type II; Region: CM_2; smart00830 264731003140 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 264731003141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731003142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731003143 homodimer interface [polypeptide binding]; other site 264731003144 catalytic residue [active] 264731003145 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 264731003146 Prephenate dehydratase; Region: PDT; pfam00800 264731003147 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264731003148 putative L-Phe binding site [chemical binding]; other site 264731003149 VirE N-terminal domain; Region: VirE_N; pfam08800 264731003150 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 264731003151 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 264731003152 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 264731003153 hypothetical protein; Provisional; Region: PRK11770 264731003154 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264731003155 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264731003156 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 264731003157 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264731003158 Catalytic site [active] 264731003159 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 264731003160 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264731003161 active site 264731003162 DNA binding site [nucleotide binding] 264731003163 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264731003164 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731003165 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 264731003166 active site 264731003167 catalytic site [active] 264731003168 substrate binding site [chemical binding]; other site 264731003169 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264731003170 core domain interface [polypeptide binding]; other site 264731003171 delta subunit interface [polypeptide binding]; other site 264731003172 epsilon subunit interface [polypeptide binding]; other site 264731003173 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264731003174 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264731003175 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264731003176 beta subunit interaction interface [polypeptide binding]; other site 264731003177 Walker A motif; other site 264731003178 ATP binding site [chemical binding]; other site 264731003179 Walker B motif; other site 264731003180 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264731003181 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 264731003182 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 264731003183 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 264731003184 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264731003185 ATP synthase subunit C; Region: ATP-synt_C; cl00466 264731003186 ATP synthase A chain; Region: ATP-synt_A; cl00413 264731003187 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264731003188 gamma subunit interface [polypeptide binding]; other site 264731003189 LBP interface [polypeptide binding]; other site 264731003190 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264731003191 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264731003192 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264731003193 alpha subunit interaction interface [polypeptide binding]; other site 264731003194 Walker A motif; other site 264731003195 ATP binding site [chemical binding]; other site 264731003196 Walker B motif; other site 264731003197 inhibitor binding site; inhibition site 264731003198 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264731003199 AAA domain; Region: AAA_28; pfam13521 264731003200 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 264731003201 putative active site; other site 264731003202 putative metal binding residues [ion binding]; other site 264731003203 putative triphosphate binding site [ion binding]; other site 264731003204 signature motif; other site 264731003205 6-phosphofructokinase; Provisional; Region: PRK03202 264731003206 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 264731003207 active site 264731003208 ADP/pyrophosphate binding site [chemical binding]; other site 264731003209 dimerization interface [polypeptide binding]; other site 264731003210 allosteric effector site; other site 264731003211 fructose-1,6-bisphosphate binding site; other site 264731003212 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264731003213 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 264731003214 transmembrane helices; other site 264731003215 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731003216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731003217 substrate binding pocket [chemical binding]; other site 264731003218 membrane-bound complex binding site; other site 264731003219 hinge residues; other site 264731003220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731003221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731003222 dimer interface [polypeptide binding]; other site 264731003223 phosphorylation site [posttranslational modification] 264731003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731003225 ATP binding site [chemical binding]; other site 264731003226 Mg2+ binding site [ion binding]; other site 264731003227 G-X-G motif; other site 264731003228 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 264731003229 putative metal binding site [ion binding]; other site 264731003230 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264731003231 HSP70 interaction site [polypeptide binding]; other site 264731003232 Maf-like protein; Region: Maf; pfam02545 264731003233 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264731003234 active site 264731003235 dimer interface [polypeptide binding]; other site 264731003236 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264731003237 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 264731003238 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 264731003239 FMN binding site [chemical binding]; other site 264731003240 dimer interface [polypeptide binding]; other site 264731003241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 264731003242 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264731003243 HD domain; Region: HD_4; pfam13328 264731003244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264731003245 synthetase active site [active] 264731003246 NTP binding site [chemical binding]; other site 264731003247 metal binding site [ion binding]; metal-binding site 264731003248 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264731003249 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264731003250 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 264731003251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264731003252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264731003253 glutamate dehydrogenase; Provisional; Region: PRK14031 264731003254 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264731003255 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 264731003256 NAD(P) binding site [chemical binding]; other site 264731003257 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264731003258 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264731003259 RNA binding site [nucleotide binding]; other site 264731003260 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264731003261 RNA binding site [nucleotide binding]; other site 264731003262 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264731003263 RNA binding site [nucleotide binding]; other site 264731003264 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264731003265 RNA binding site [nucleotide binding]; other site 264731003266 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264731003267 RNA binding site [nucleotide binding]; other site 264731003268 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 264731003269 RNA binding site [nucleotide binding]; other site 264731003270 heat shock protein 90; Provisional; Region: PRK05218 264731003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731003272 ATP binding site [chemical binding]; other site 264731003273 Mg2+ binding site [ion binding]; other site 264731003274 G-X-G motif; other site 264731003275 Cache domain; Region: Cache_1; pfam02743 264731003276 HAMP domain; Region: HAMP; pfam00672 264731003277 dimerization interface [polypeptide binding]; other site 264731003278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731003279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731003280 dimer interface [polypeptide binding]; other site 264731003281 phosphorylation site [posttranslational modification] 264731003282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731003283 ATP binding site [chemical binding]; other site 264731003284 Mg2+ binding site [ion binding]; other site 264731003285 G-X-G motif; other site 264731003286 Cache domain; Region: Cache_1; pfam02743 264731003287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731003288 dimerization interface [polypeptide binding]; other site 264731003289 Cache domain; Region: Cache_1; pfam02743 264731003290 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 264731003291 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264731003292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731003293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731003294 DNA binding residues [nucleotide binding] 264731003295 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264731003296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731003297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731003298 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264731003299 dihydrodipicolinate synthase; Region: dapA; TIGR00674 264731003300 dimer interface [polypeptide binding]; other site 264731003301 active site 264731003302 catalytic residue [active] 264731003303 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264731003304 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264731003305 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 264731003306 Peptidase C10 family; Region: Peptidase_C10; pfam01640 264731003307 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731003308 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731003309 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731003310 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 264731003311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264731003312 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 264731003313 dimer interface [polypeptide binding]; other site 264731003314 substrate binding site [chemical binding]; other site 264731003315 metal binding site [ion binding]; metal-binding site 264731003316 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264731003317 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264731003318 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264731003319 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264731003320 carboxyltransferase (CT) interaction site; other site 264731003321 biotinylation site [posttranslational modification]; other site 264731003322 AAA domain; Region: AAA_14; pfam13173 264731003323 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 264731003324 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 264731003325 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264731003326 dimer interface [polypeptide binding]; other site 264731003327 PYR/PP interface [polypeptide binding]; other site 264731003328 TPP binding site [chemical binding]; other site 264731003329 substrate binding site [chemical binding]; other site 264731003330 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264731003331 Domain of unknown function; Region: EKR; pfam10371 264731003332 4Fe-4S binding domain; Region: Fer4_6; pfam12837 264731003333 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 264731003334 TPP-binding site [chemical binding]; other site 264731003335 dimer interface [polypeptide binding]; other site 264731003336 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 264731003337 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264731003338 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264731003339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264731003340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264731003341 dimerization interface [polypeptide binding]; other site 264731003342 TrkA-C domain; Region: TrkA_C; pfam02080 264731003343 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 264731003344 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 264731003345 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264731003346 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264731003347 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264731003348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264731003349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264731003350 DNA binding site [nucleotide binding] 264731003351 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731003352 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 264731003353 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 264731003354 Pyruvate formate lyase 1; Region: PFL1; cd01678 264731003355 coenzyme A binding site [chemical binding]; other site 264731003356 active site 264731003357 catalytic residues [active] 264731003358 glycine loop; other site 264731003359 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 264731003360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731003361 FeS/SAM binding site; other site 264731003362 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 264731003363 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264731003364 catalytic loop [active] 264731003365 iron binding site [ion binding]; other site 264731003366 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 264731003367 FAD binding pocket [chemical binding]; other site 264731003368 FAD binding motif [chemical binding]; other site 264731003369 phosphate binding motif [ion binding]; other site 264731003370 beta-alpha-beta structure motif; other site 264731003371 NAD binding pocket [chemical binding]; other site 264731003372 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 264731003373 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 264731003374 FMN-binding domain; Region: FMN_bind; cl01081 264731003375 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 264731003376 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 264731003377 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 264731003378 Family of unknown function (DUF490); Region: DUF490; pfam04357 264731003379 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264731003380 EamA-like transporter family; Region: EamA; cl17759 264731003381 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264731003382 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264731003383 dimerization interface 3.5A [polypeptide binding]; other site 264731003384 active site 264731003385 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 264731003386 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264731003387 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 264731003388 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264731003389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731003390 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731003391 Outer membrane efflux protein; Region: OEP; pfam02321 264731003392 Outer membrane efflux protein; Region: OEP; pfam02321 264731003393 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731003394 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 264731003395 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 264731003396 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264731003397 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264731003398 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731003399 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731003400 catalytic residues [active] 264731003401 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264731003402 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264731003403 Na binding site [ion binding]; other site 264731003404 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 264731003405 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731003406 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731003407 N-terminal plug; other site 264731003408 ligand-binding site [chemical binding]; other site 264731003409 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 264731003410 DNA topoisomerase III; Provisional; Region: PRK07726 264731003411 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264731003412 active site 264731003413 putative interdomain interaction site [polypeptide binding]; other site 264731003414 putative metal-binding site [ion binding]; other site 264731003415 putative nucleotide binding site [chemical binding]; other site 264731003416 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264731003417 domain I; other site 264731003418 DNA binding groove [nucleotide binding] 264731003419 phosphate binding site [ion binding]; other site 264731003420 domain II; other site 264731003421 domain III; other site 264731003422 nucleotide binding site [chemical binding]; other site 264731003423 catalytic site [active] 264731003424 domain IV; other site 264731003425 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731003427 binding surface 264731003428 TPR motif; other site 264731003429 TPR repeat; Region: TPR_11; pfam13414 264731003430 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731003431 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731003432 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264731003433 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264731003434 ligand binding site [chemical binding]; other site 264731003435 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264731003436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731003437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731003438 DNA binding residues [nucleotide binding] 264731003439 PspC domain; Region: PspC; pfam04024 264731003440 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 264731003441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731003442 S-adenosylmethionine binding site [chemical binding]; other site 264731003443 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 264731003444 thymidylate synthase; Reviewed; Region: thyA; PRK01827 264731003445 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264731003446 dimerization interface [polypeptide binding]; other site 264731003447 active site 264731003448 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264731003449 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264731003450 folate binding site [chemical binding]; other site 264731003451 NADP+ binding site [chemical binding]; other site 264731003452 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 264731003453 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 264731003454 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 264731003455 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731003456 N-terminal plug; other site 264731003457 ligand-binding site [chemical binding]; other site 264731003458 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264731003459 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 264731003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731003461 Walker A motif; other site 264731003462 ATP binding site [chemical binding]; other site 264731003463 Walker B motif; other site 264731003464 arginine finger; other site 264731003465 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264731003466 DnaA box-binding interface [nucleotide binding]; other site 264731003467 mce related protein; Region: MCE; pfam02470 264731003468 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 264731003469 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264731003470 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264731003471 active site 264731003472 metal binding site [ion binding]; metal-binding site 264731003473 Dihydroneopterin aldolase; Region: FolB; smart00905 264731003474 active site 264731003475 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 264731003476 dimer interface [polypeptide binding]; other site 264731003477 FMN binding site [chemical binding]; other site 264731003478 NADPH bind site [chemical binding]; other site 264731003479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731003480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731003481 putative substrate translocation pore; other site 264731003482 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 264731003483 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 264731003484 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 264731003485 Cache domain; Region: Cache_1; pfam02743 264731003486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731003487 HAMP domain; Region: HAMP; pfam00672 264731003488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731003489 dimer interface [polypeptide binding]; other site 264731003490 phosphorylation site [posttranslational modification] 264731003491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731003492 ATP binding site [chemical binding]; other site 264731003493 Mg2+ binding site [ion binding]; other site 264731003494 G-X-G motif; other site 264731003495 Cache domain; Region: Cache_1; pfam02743 264731003496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731003497 dimerization interface [polypeptide binding]; other site 264731003498 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 264731003499 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 264731003500 nudix motif; other site 264731003501 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264731003502 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 264731003503 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264731003504 catalytic residue [active] 264731003505 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264731003506 active site 264731003507 ATP binding site [chemical binding]; other site 264731003508 substrate binding site [chemical binding]; other site 264731003509 activation loop (A-loop); other site 264731003510 aspartate aminotransferase; Provisional; Region: PRK07568 264731003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731003513 homodimer interface [polypeptide binding]; other site 264731003514 catalytic residue [active] 264731003515 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264731003516 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731003517 FtsX-like permease family; Region: FtsX; pfam02687 264731003518 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264731003519 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731003520 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731003521 acyl-activating enzyme (AAE) consensus motif; other site 264731003522 acyl-activating enzyme (AAE) consensus motif; other site 264731003523 AMP binding site [chemical binding]; other site 264731003524 active site 264731003525 CoA binding site [chemical binding]; other site 264731003526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731003527 AMP-binding enzyme; Region: AMP-binding; pfam00501 264731003528 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731003529 acyl-activating enzyme (AAE) consensus motif; other site 264731003530 active site 264731003531 AMP binding site [chemical binding]; other site 264731003532 CoA binding site [chemical binding]; other site 264731003533 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 264731003534 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 264731003535 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 264731003536 active site 264731003537 catalytic site [active] 264731003538 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 264731003539 Domain of unknown function (DUF386); Region: DUF386; cl01047 264731003540 MORN repeat; Region: MORN; cl14787 264731003541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 264731003542 MORN repeat; Region: MORN; cl14787 264731003543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 264731003544 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 264731003545 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264731003546 Ligand binding site; other site 264731003547 oligomer interface; other site 264731003548 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264731003549 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264731003550 HSP70 interaction site [polypeptide binding]; other site 264731003551 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264731003552 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264731003553 dimer interface [polypeptide binding]; other site 264731003554 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 264731003555 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 264731003556 active site 264731003557 metal binding site [ion binding]; metal-binding site 264731003558 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264731003559 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 264731003560 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264731003561 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 264731003562 putative NADH binding site [chemical binding]; other site 264731003563 putative active site [active] 264731003564 nudix motif; other site 264731003565 putative metal binding site [ion binding]; other site 264731003566 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264731003567 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264731003568 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264731003569 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264731003570 Sporulation related domain; Region: SPOR; pfam05036 264731003571 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264731003572 phosphopeptide binding site; other site 264731003573 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 264731003574 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 264731003575 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731003576 active site 264731003577 NTP binding site [chemical binding]; other site 264731003578 metal binding triad [ion binding]; metal-binding site 264731003579 antibiotic binding site [chemical binding]; other site 264731003580 HEPN domain; Region: HEPN; cl00824 264731003581 CRISPR repeat region, Nmeni subtype 264731003582 CRISPR spacer 264731003583 CRISPR spacer 264731003584 CRISPR spacer 264731003585 CRISPR spacer 264731003586 CRISPR spacer 264731003587 CRISPR spacer 264731003588 CRISPR spacer 264731003589 CRISPR spacer 264731003590 CRISPR spacer 264731003591 CRISPR spacer 264731003592 CRISPR spacer 264731003593 CRISPR spacer 264731003594 CRISPR spacer 264731003595 CRISPR spacer 264731003596 CRISPR spacer 264731003597 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 264731003598 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 264731003599 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 264731003600 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 264731003601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731003602 non-specific DNA binding site [nucleotide binding]; other site 264731003603 salt bridge; other site 264731003604 sequence-specific DNA binding site [nucleotide binding]; other site 264731003605 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 264731003606 IHF dimer interface [polypeptide binding]; other site 264731003607 VirE N-terminal domain; Region: VirE_N; pfam08800 264731003608 Virulence-associated protein E; Region: VirE; pfam05272 264731003609 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264731003610 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 264731003611 Glucose inhibited division protein A; Region: GIDA; pfam01134 264731003612 hypothetical protein; Provisional; Region: PRK05802 264731003613 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 264731003614 FAD binding pocket [chemical binding]; other site 264731003615 FAD binding motif [chemical binding]; other site 264731003616 phosphate binding motif [ion binding]; other site 264731003617 beta-alpha-beta structure motif; other site 264731003618 NAD binding pocket [chemical binding]; other site 264731003619 Iron coordination center [ion binding]; other site 264731003620 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264731003621 SLBB domain; Region: SLBB; pfam10531 264731003622 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 264731003623 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 264731003624 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264731003625 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731003626 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 264731003627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731003628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731003629 active site 264731003630 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 264731003631 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 264731003632 GDP-Fucose binding site [chemical binding]; other site 264731003633 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731003634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731003635 active site 264731003636 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264731003637 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 264731003638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264731003639 catalytic core [active] 264731003640 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 264731003641 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 264731003642 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 264731003643 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 264731003644 Sugar specificity; other site 264731003645 Pyrimidine base specificity; other site 264731003646 ATP-binding site [chemical binding]; other site 264731003647 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 264731003648 putative active site [active] 264731003649 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264731003650 putative catalytic site [active] 264731003651 putative metal binding site [ion binding]; other site 264731003652 putative phosphate binding site [ion binding]; other site 264731003653 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 264731003654 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264731003655 catalytic residues [active] 264731003656 dimer interface [polypeptide binding]; other site 264731003657 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264731003658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264731003659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264731003660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731003661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731003662 dimer interface [polypeptide binding]; other site 264731003663 phosphorylation site [posttranslational modification] 264731003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731003665 ATP binding site [chemical binding]; other site 264731003666 Mg2+ binding site [ion binding]; other site 264731003667 G-X-G motif; other site 264731003668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264731003669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731003670 active site 264731003671 phosphorylation site [posttranslational modification] 264731003672 intermolecular recognition site; other site 264731003673 dimerization interface [polypeptide binding]; other site 264731003674 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264731003675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731003676 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 264731003677 Na binding site [ion binding]; other site 264731003678 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 264731003679 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 264731003680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731003681 catalytic residue [active] 264731003682 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 264731003683 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 264731003684 Outer membrane lipoprotein; Region: YfiO; pfam13525 264731003685 excinuclease ABC subunit B; Provisional; Region: PRK05298 264731003686 AAA domain; Region: AAA_30; pfam13604 264731003687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731003688 ATP binding site [chemical binding]; other site 264731003689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731003690 nucleotide binding region [chemical binding]; other site 264731003691 ATP-binding site [chemical binding]; other site 264731003692 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264731003693 UvrB/uvrC motif; Region: UVR; pfam02151 264731003694 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 264731003695 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 264731003696 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 264731003697 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 264731003698 UbiA prenyltransferase family; Region: UbiA; pfam01040 264731003699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 264731003700 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264731003701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731003702 RNA binding surface [nucleotide binding]; other site 264731003703 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264731003704 active site 264731003705 glucuronate isomerase; Reviewed; Region: PRK02925 264731003706 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 264731003707 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826 264731003708 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 264731003709 ATP cone domain; Region: ATP-cone; pfam03477 264731003710 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 264731003711 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 264731003712 Rubrerythrin [Energy production and conversion]; Region: COG1592 264731003713 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 264731003714 binuclear metal center [ion binding]; other site 264731003715 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 264731003716 iron binding site [ion binding]; other site 264731003717 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264731003718 active site 264731003719 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 264731003720 homodimer interface [polypeptide binding]; other site 264731003721 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264731003722 Lumazine binding domain; Region: Lum_binding; pfam00677 264731003723 Lumazine binding domain; Region: Lum_binding; pfam00677 264731003724 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264731003725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731003726 motif II; other site 264731003727 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 264731003728 4-alpha-glucanotransferase; Region: PLN02950 264731003729 starch-binding site 2 [chemical binding]; other site 264731003730 starch-binding site 1 [chemical binding]; other site 264731003731 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 264731003732 starch-binding site 2 [chemical binding]; other site 264731003733 starch-binding site 1 [chemical binding]; other site 264731003734 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 264731003735 YceG-like family; Region: YceG; pfam02618 264731003736 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264731003737 dimerization interface [polypeptide binding]; other site 264731003738 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 264731003739 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731003740 active site 264731003741 HIGH motif; other site 264731003742 nucleotide binding site [chemical binding]; other site 264731003743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731003744 active site 264731003745 KMSKS motif; other site 264731003746 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 264731003747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731003748 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264731003749 TPR motif; other site 264731003750 binding surface 264731003751 TPR repeat; Region: TPR_11; pfam13414 264731003752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731003753 binding surface 264731003754 TPR motif; other site 264731003755 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264731003756 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 264731003757 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 264731003758 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264731003759 Substrate binding site; other site 264731003760 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 264731003761 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 264731003762 NADP-binding site; other site 264731003763 homotetramer interface [polypeptide binding]; other site 264731003764 substrate binding site [chemical binding]; other site 264731003765 homodimer interface [polypeptide binding]; other site 264731003766 active site 264731003767 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 264731003768 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 264731003769 NADP binding site [chemical binding]; other site 264731003770 active site 264731003771 putative substrate binding site [chemical binding]; other site 264731003772 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 264731003773 D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810 264731003774 putative N- and C-terminal domain interface [polypeptide binding]; other site 264731003775 putative active site [active] 264731003776 putative MgATP binding site [chemical binding]; other site 264731003777 catalytic site [active] 264731003778 metal binding site [ion binding]; metal-binding site 264731003779 putative xylulose binding site [chemical binding]; other site 264731003780 putative homodimer interface [polypeptide binding]; other site 264731003781 Response regulator receiver domain; Region: Response_reg; pfam00072 264731003782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731003783 active site 264731003784 phosphorylation site [posttranslational modification] 264731003785 intermolecular recognition site; other site 264731003786 dimerization interface [polypeptide binding]; other site 264731003787 Bacterial sugar transferase; Region: Bac_transf; cl00939 264731003788 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264731003789 Outer membrane efflux protein; Region: OEP; pfam02321 264731003790 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 264731003791 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731003792 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 264731003793 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264731003794 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264731003795 Probable Catalytic site; other site 264731003796 metal-binding site 264731003797 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264731003798 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 264731003799 DXD motif; other site 264731003800 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264731003801 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 264731003802 DXD motif; other site 264731003803 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 264731003804 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731003805 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264731003806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731003807 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 264731003808 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731003809 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 264731003810 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731003811 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 264731003812 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731003813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731003814 active site 264731003815 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264731003816 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731003817 lipase chaperone; Provisional; Region: PRK01294 264731003818 VirE N-terminal domain; Region: VirE_N; pfam08800 264731003819 Virulence-associated protein E; Region: VirE; pfam05272 264731003820 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731003821 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731003822 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731003823 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731003824 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731003825 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 264731003826 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 264731003827 Leucine rich repeat; Region: LRR_8; pfam13855 264731003828 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003829 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003830 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003831 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003832 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003833 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003834 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003835 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003836 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003837 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003838 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003839 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731003840 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 264731003841 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 264731003842 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264731003843 minor groove reading motif; other site 264731003844 helix-hairpin-helix signature motif; other site 264731003845 substrate binding pocket [chemical binding]; other site 264731003846 active site 264731003847 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 264731003848 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731003849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731003850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731003851 DNA binding residues [nucleotide binding] 264731003852 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264731003853 ribonuclease Z; Region: RNase_Z; TIGR02651 264731003854 Lipocalin-like; Region: Lipocalin_3; pfam12702 264731003855 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 264731003856 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 264731003857 homodimer interface [polypeptide binding]; other site 264731003858 metal binding site [ion binding]; metal-binding site 264731003859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 264731003860 homodimer interface [polypeptide binding]; other site 264731003861 active site 264731003862 putative chemical substrate binding site [chemical binding]; other site 264731003863 metal binding site [ion binding]; metal-binding site 264731003864 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264731003865 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731003866 active site 264731003867 HIGH motif; other site 264731003868 nucleotide binding site [chemical binding]; other site 264731003869 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264731003870 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264731003871 active site 264731003872 KMSKS motif; other site 264731003873 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264731003874 tRNA binding surface [nucleotide binding]; other site 264731003875 anticodon binding site; other site 264731003876 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264731003877 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 264731003878 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264731003879 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 264731003880 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 264731003881 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 264731003882 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264731003883 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 264731003884 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 264731003885 putative active site; other site 264731003886 catalytic triad [active] 264731003887 putative dimer interface [polypeptide binding]; other site 264731003888 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 264731003889 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 264731003890 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 264731003891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264731003892 Walker A/P-loop; other site 264731003893 ATP binding site [chemical binding]; other site 264731003894 Q-loop/lid; other site 264731003895 ABC transporter signature motif; other site 264731003896 Walker B; other site 264731003897 D-loop; other site 264731003898 H-loop/switch region; other site 264731003899 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 264731003900 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 264731003901 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731003902 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 264731003903 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731003904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731003905 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 264731003906 putative ADP-binding pocket [chemical binding]; other site 264731003907 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731003908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731003909 active site 264731003910 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 264731003911 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 264731003912 LicD family; Region: LicD; cl01378 264731003913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731003914 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731003915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731003916 active site 264731003917 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 264731003918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731003919 putative ADP-binding pocket [chemical binding]; other site 264731003920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731003921 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 264731003922 putative ADP-binding pocket [chemical binding]; other site 264731003923 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 264731003924 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 264731003925 trimer interface [polypeptide binding]; other site 264731003926 active site 264731003927 substrate binding site [chemical binding]; other site 264731003928 CoA binding site [chemical binding]; other site 264731003929 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264731003930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731003931 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264731003932 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264731003933 dimer interface [polypeptide binding]; other site 264731003934 anticodon binding site; other site 264731003935 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264731003936 homodimer interface [polypeptide binding]; other site 264731003937 motif 1; other site 264731003938 active site 264731003939 motif 2; other site 264731003940 GAD domain; Region: GAD; pfam02938 264731003941 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264731003942 motif 3; other site 264731003943 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 264731003944 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 264731003945 membrane protein insertase; Provisional; Region: PRK01318 264731003946 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264731003947 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 264731003948 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731003949 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731003950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731003951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 264731003952 hypothetical protein; Provisional; Region: PRK13663 264731003953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731003954 putative substrate translocation pore; other site 264731003955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731003956 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264731003957 putative catalytic site [active] 264731003958 putative metal binding site [ion binding]; other site 264731003959 putative phosphate binding site [ion binding]; other site 264731003960 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 264731003961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731003962 putative substrate translocation pore; other site 264731003963 POT family; Region: PTR2; cl17359 264731003964 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264731003965 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264731003966 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264731003967 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cd01391 264731003968 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 264731003969 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264731003970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264731003971 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264731003972 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264731003973 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 264731003974 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264731003975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731003976 catalytic residue [active] 264731003977 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 264731003978 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264731003979 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264731003980 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264731003981 Glutamine amidotransferase class-I; Region: GATase; pfam00117 264731003982 glutamine binding [chemical binding]; other site 264731003983 catalytic triad [active] 264731003984 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264731003985 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264731003986 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264731003987 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264731003988 active site 264731003989 ribulose/triose binding site [chemical binding]; other site 264731003990 phosphate binding site [ion binding]; other site 264731003991 substrate (anthranilate) binding pocket [chemical binding]; other site 264731003992 product (indole) binding pocket [chemical binding]; other site 264731003993 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 264731003994 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264731003995 substrate binding site [chemical binding]; other site 264731003996 active site 264731003997 catalytic residues [active] 264731003998 heterodimer interface [polypeptide binding]; other site 264731003999 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 264731004000 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264731004001 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 264731004002 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 264731004003 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731004004 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004005 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731004006 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731004007 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731004008 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731004009 SusD family; Region: SusD; pfam07980 264731004010 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 264731004011 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 264731004012 intersubunit interface [polypeptide binding]; other site 264731004013 active site 264731004014 Zn2+ binding site [ion binding]; other site 264731004015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731004016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731004017 putative substrate translocation pore; other site 264731004018 L-rhamnose isomerase; Provisional; Region: PRK01076 264731004019 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 264731004020 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 264731004021 N- and C-terminal domain interface [polypeptide binding]; other site 264731004022 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 264731004023 active site 264731004024 putative catalytic site [active] 264731004025 metal binding site [ion binding]; metal-binding site 264731004026 ATP binding site [chemical binding]; other site 264731004027 carbohydrate binding site [chemical binding]; other site 264731004028 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264731004029 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731004030 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731004031 Domain of unknown function (DUF718); Region: DUF718; pfam05336 264731004032 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 264731004033 active site 264731004034 catalytic triad [active] 264731004035 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 264731004036 active site 264731004037 catalytic triad [active] 264731004038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264731004039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264731004040 active site 264731004041 catalytic tetrad [active] 264731004042 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731004043 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264731004044 Peptidase C13 family; Region: Peptidase_C13; cl02159 264731004045 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731004046 catalytic residues [active] 264731004047 rare lipoprotein A; Provisional; Region: PRK10672 264731004048 PIN domain; Region: PIN_3; pfam13470 264731004049 Fic family protein [Function unknown]; Region: COG3177 264731004050 Fic/DOC family; Region: Fic; pfam02661 264731004051 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731004052 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 264731004053 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 264731004054 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 264731004055 WYL domain; Region: WYL; pfam13280 264731004056 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731004057 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264731004058 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264731004059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731004060 non-specific DNA binding site [nucleotide binding]; other site 264731004061 salt bridge; other site 264731004062 sequence-specific DNA binding site [nucleotide binding]; other site 264731004063 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 264731004064 active site 264731004065 catalytic triad [active] 264731004066 oxyanion hole [active] 264731004067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 264731004068 active site 2 [active] 264731004069 hypothetical protein; Provisional; Region: PRK10410 264731004070 DNA polymerase II large subunit; Provisional; Region: PRK14714 264731004071 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264731004072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731004073 Coenzyme A binding pocket [chemical binding]; other site 264731004074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731004075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731004076 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264731004077 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264731004078 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264731004079 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264731004080 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 264731004081 Uncharacterized conserved protein [Function unknown]; Region: COG4925 264731004082 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264731004083 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264731004084 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264731004085 Walker A/P-loop; other site 264731004086 ATP binding site [chemical binding]; other site 264731004087 Q-loop/lid; other site 264731004088 ABC transporter signature motif; other site 264731004089 Walker B; other site 264731004090 D-loop; other site 264731004091 H-loop/switch region; other site 264731004092 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264731004093 CoenzymeA binding site [chemical binding]; other site 264731004094 subunit interaction site [polypeptide binding]; other site 264731004095 PHB binding site; other site 264731004096 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 264731004097 pyruvate phosphate dikinase; Provisional; Region: PRK09279 264731004098 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264731004099 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264731004100 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264731004101 TRAM domain; Region: TRAM; cl01282 264731004102 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264731004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731004104 S-adenosylmethionine binding site [chemical binding]; other site 264731004105 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 264731004106 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264731004107 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731004108 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731004109 active site 264731004110 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 264731004111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731004112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004113 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 264731004114 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 264731004115 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 264731004116 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731004117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731004118 active site 264731004119 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 264731004120 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731004121 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731004122 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731004123 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 264731004124 Transposase IS200 like; Region: Y1_Tnp; cl00848 264731004125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004126 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731004127 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731004128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004129 FkbH-like domain; Region: FkbH; TIGR01686 264731004130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731004131 active site 264731004132 motif I; other site 264731004133 motif II; other site 264731004134 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 264731004135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731004136 UDP-galactopyranose mutase; Region: GLF; pfam03275 264731004137 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 264731004138 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264731004139 trimer interface [polypeptide binding]; other site 264731004140 active site 264731004141 substrate binding site [chemical binding]; other site 264731004142 CoA binding site [chemical binding]; other site 264731004143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004144 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264731004145 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 264731004146 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264731004147 putative glycosyl transferase; Provisional; Region: PRK10073 264731004148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731004149 active site 264731004150 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 264731004151 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 264731004152 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 264731004153 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264731004154 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 264731004155 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 264731004156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731004157 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731004158 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 264731004159 putative NAD(P) binding site [chemical binding]; other site 264731004160 active site 264731004161 putative substrate binding site [chemical binding]; other site 264731004162 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731004163 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 264731004164 active site 264731004165 Substrate binding site; other site 264731004166 Mg++ binding site; other site 264731004167 galactokinase; Region: PLN02865 264731004168 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264731004169 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264731004170 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 264731004171 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 264731004172 High-affinity nickel-transport protein; Region: NicO; cl00964 264731004173 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264731004174 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 264731004175 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 264731004176 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 264731004177 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264731004178 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 264731004179 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 264731004180 metal binding site [ion binding]; metal-binding site 264731004181 dimer interface [polypeptide binding]; other site 264731004182 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264731004183 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 264731004184 Cl binding site [ion binding]; other site 264731004185 oligomer interface [polypeptide binding]; other site 264731004186 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 264731004187 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 264731004188 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 264731004189 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 264731004190 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 264731004191 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264731004192 nucleoside/Zn binding site; other site 264731004193 dimer interface [polypeptide binding]; other site 264731004194 catalytic motif [active] 264731004195 protein translocase, SecG subunit; Region: secG; TIGR00810 264731004196 Lipopolysaccharide-assembly; Region: LptE; pfam04390 264731004197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731004198 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731004199 Walker A motif; other site 264731004200 ATP binding site [chemical binding]; other site 264731004201 Walker B motif; other site 264731004202 arginine finger; other site 264731004203 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264731004204 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264731004205 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264731004206 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 264731004207 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 264731004208 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731004209 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731004210 active site 264731004211 GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103 264731004212 Stage II sporulation protein; Region: SpoIID; pfam08486 264731004213 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 264731004214 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264731004215 muropeptide transporter; Validated; Region: ampG; cl17669 264731004216 serine O-acetyltransferase; Region: cysE; TIGR01172 264731004217 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264731004218 trimer interface [polypeptide binding]; other site 264731004219 active site 264731004220 substrate binding site [chemical binding]; other site 264731004221 CoA binding site [chemical binding]; other site 264731004222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264731004223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264731004224 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264731004225 dimerization interface [polypeptide binding]; other site 264731004226 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264731004227 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731004228 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 264731004229 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 264731004230 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731004231 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731004232 SusD family; Region: SusD; pfam07980 264731004233 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004234 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731004235 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731004236 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731004237 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 264731004238 metal binding site [ion binding]; metal-binding site 264731004239 active site 264731004240 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731004241 WW domain-binding protein 1; Region: WBP-1; pfam11669 264731004242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731004244 dimer interface [polypeptide binding]; other site 264731004245 phosphorylation site [posttranslational modification] 264731004246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004247 ATP binding site [chemical binding]; other site 264731004248 Mg2+ binding site [ion binding]; other site 264731004249 G-X-G motif; other site 264731004250 Response regulator receiver domain; Region: Response_reg; pfam00072 264731004251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731004252 active site 264731004253 phosphorylation site [posttranslational modification] 264731004254 intermolecular recognition site; other site 264731004255 dimerization interface [polypeptide binding]; other site 264731004256 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731004257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731004258 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731004259 amidase catalytic site [active] 264731004260 Zn binding residues [ion binding]; other site 264731004261 substrate binding site [chemical binding]; other site 264731004262 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731004263 Virulence-associated protein E; Region: VirE; pfam05272 264731004264 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 264731004265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004267 ATP binding site [chemical binding]; other site 264731004268 Mg2+ binding site [ion binding]; other site 264731004269 G-X-G motif; other site 264731004270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004272 ATP binding site [chemical binding]; other site 264731004273 Mg2+ binding site [ion binding]; other site 264731004274 G-X-G motif; other site 264731004275 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264731004276 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 264731004277 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264731004278 active site 264731004279 NTP binding site [chemical binding]; other site 264731004280 nucleic acid binding site [nucleotide binding]; other site 264731004281 Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321 264731004282 Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984 264731004283 TPR repeat; Region: TPR_11; pfam13414 264731004284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731004285 binding surface 264731004286 TPR motif; other site 264731004287 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 264731004288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264731004289 active site 264731004290 DNA binding site [nucleotide binding] 264731004291 Int/Topo IB signature motif; other site 264731004292 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 264731004293 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731004294 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731004295 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731004296 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731004297 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731004298 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004299 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731004300 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731004301 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 264731004302 active site 264731004303 catalytic triad [active] 264731004304 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731004305 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731004306 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731004307 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731004308 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004309 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731004310 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731004311 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731004312 SusD family; Region: SusD; pfam07980 264731004313 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264731004314 Interdomain contacts; other site 264731004315 Cytokine receptor motif; other site 264731004316 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 264731004317 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 264731004318 putative catalytic site [active] 264731004319 putative metal binding site [ion binding]; other site 264731004320 putative phosphate binding site [ion binding]; other site 264731004321 Carboxylesterase family; Region: COesterase; pfam00135 264731004322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264731004323 substrate binding pocket [chemical binding]; other site 264731004324 catalytic triad [active] 264731004325 L-lactate permease; Region: Lactate_perm; cl00701 264731004326 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 264731004327 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 264731004328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731004330 putative substrate translocation pore; other site 264731004331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731004333 dimer interface [polypeptide binding]; other site 264731004334 phosphorylation site [posttranslational modification] 264731004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004336 ATP binding site [chemical binding]; other site 264731004337 Mg2+ binding site [ion binding]; other site 264731004338 G-X-G motif; other site 264731004339 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264731004340 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264731004341 putative dimer interface [polypeptide binding]; other site 264731004342 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264731004343 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 264731004344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731004345 ATP binding site [chemical binding]; other site 264731004346 putative Mg++ binding site [ion binding]; other site 264731004347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731004348 nucleotide binding region [chemical binding]; other site 264731004349 ATP-binding site [chemical binding]; other site 264731004350 TRCF domain; Region: TRCF; pfam03461 264731004351 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731004352 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 264731004353 Ligand binding site; other site 264731004354 Putative Catalytic site; other site 264731004355 DXD motif; other site 264731004356 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264731004357 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264731004358 putative acyl-acceptor binding pocket; other site 264731004359 phosphodiesterase YaeI; Provisional; Region: PRK11340 264731004360 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264731004361 putative active site [active] 264731004362 putative metal binding site [ion binding]; other site 264731004363 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 264731004364 dihydroorotase; Reviewed; Region: PRK09236 264731004365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264731004366 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 264731004367 active site 264731004368 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731004369 Septum formation initiator; Region: DivIC; pfam04977 264731004370 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 264731004371 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 264731004372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731004373 Walker A motif; other site 264731004374 ATP binding site [chemical binding]; other site 264731004375 Walker B motif; other site 264731004376 arginine finger; other site 264731004377 Response regulator receiver domain; Region: Response_reg; pfam00072 264731004378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731004379 active site 264731004380 phosphorylation site [posttranslational modification] 264731004381 intermolecular recognition site; other site 264731004382 dimerization interface [polypeptide binding]; other site 264731004383 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 264731004384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731004385 putative substrate translocation pore; other site 264731004386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731004388 dimer interface [polypeptide binding]; other site 264731004389 phosphorylation site [posttranslational modification] 264731004390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004391 ATP binding site [chemical binding]; other site 264731004392 Mg2+ binding site [ion binding]; other site 264731004393 G-X-G motif; other site 264731004394 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 264731004395 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 264731004396 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 264731004397 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 264731004398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264731004399 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264731004400 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264731004401 KpsF/GutQ family protein; Region: kpsF; TIGR00393 264731004402 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264731004403 putative active site [active] 264731004404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264731004405 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731004406 Response regulator receiver domain; Region: Response_reg; pfam00072 264731004407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731004408 active site 264731004409 phosphorylation site [posttranslational modification] 264731004410 intermolecular recognition site; other site 264731004411 dimerization interface [polypeptide binding]; other site 264731004412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731004413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731004414 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264731004415 PLD-like domain; Region: PLDc_2; pfam13091 264731004416 putative active site [active] 264731004417 catalytic site [active] 264731004418 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 264731004419 PLD-like domain; Region: PLDc_2; pfam13091 264731004420 putative active site [active] 264731004421 catalytic site [active] 264731004422 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 264731004423 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731004424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731004425 binding surface 264731004426 TPR motif; other site 264731004427 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264731004428 DNA repair protein RadA; Provisional; Region: PRK11823 264731004429 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264731004430 Walker A motif/ATP binding site; other site 264731004431 ATP binding site [chemical binding]; other site 264731004432 Walker B motif; other site 264731004433 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264731004434 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 264731004435 Phosphoglycerate kinase; Region: PGK; pfam00162 264731004436 substrate binding site [chemical binding]; other site 264731004437 hinge regions; other site 264731004438 ADP binding site [chemical binding]; other site 264731004439 catalytic site [active] 264731004440 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731004441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264731004442 dimer interface [polypeptide binding]; other site 264731004443 conserved gate region; other site 264731004444 putative PBP binding loops; other site 264731004445 ABC-ATPase subunit interface; other site 264731004446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731004447 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731004448 membrane-bound complex binding site; other site 264731004449 hinge residues; other site 264731004450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731004451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731004452 substrate binding pocket [chemical binding]; other site 264731004453 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264731004454 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264731004455 Walker A/P-loop; other site 264731004456 ATP binding site [chemical binding]; other site 264731004457 Q-loop/lid; other site 264731004458 ABC transporter signature motif; other site 264731004459 Walker B; other site 264731004460 D-loop; other site 264731004461 H-loop/switch region; other site 264731004462 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 264731004463 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264731004464 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 264731004465 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 264731004466 active site 264731004467 substrate binding site [chemical binding]; other site 264731004468 coenzyme B12 binding site [chemical binding]; other site 264731004469 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 264731004470 B12 binding site [chemical binding]; other site 264731004471 cobalt ligand [ion binding]; other site 264731004472 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 264731004473 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 264731004474 heterodimer interface [polypeptide binding]; other site 264731004475 substrate interaction site [chemical binding]; other site 264731004476 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264731004477 putative transporter; Validated; Region: PRK03818 264731004478 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264731004479 TrkA-C domain; Region: TrkA_C; pfam02080 264731004480 TrkA-C domain; Region: TrkA_C; pfam02080 264731004481 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264731004482 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 264731004483 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264731004484 carboxyltransferase (CT) interaction site; other site 264731004485 biotinylation site [posttranslational modification]; other site 264731004486 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 264731004487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264731004488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264731004489 DNA binding residues [nucleotide binding] 264731004490 dimerization interface [polypeptide binding]; other site 264731004491 altronate oxidoreductase; Provisional; Region: PRK03643 264731004492 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 264731004493 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 264731004494 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264731004495 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264731004496 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264731004497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731004498 Walker A/P-loop; other site 264731004499 ATP binding site [chemical binding]; other site 264731004500 Q-loop/lid; other site 264731004501 ABC transporter signature motif; other site 264731004502 Walker B; other site 264731004503 D-loop; other site 264731004504 H-loop/switch region; other site 264731004505 Part of AAA domain; Region: AAA_19; pfam13245 264731004506 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 264731004507 Family description; Region: UvrD_C_2; pfam13538 264731004508 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264731004509 probable DNA repair protein; Region: TIGR03623 264731004510 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264731004511 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 264731004512 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264731004513 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 264731004514 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264731004515 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264731004516 putative transporter; Provisional; Region: PRK11660 264731004517 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264731004518 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264731004519 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 264731004520 active site 264731004521 putative catalytic site [active] 264731004522 DNA binding site [nucleotide binding] 264731004523 putative phosphate binding site [ion binding]; other site 264731004524 metal binding site A [ion binding]; metal-binding site 264731004525 AP binding site [nucleotide binding]; other site 264731004526 metal binding site B [ion binding]; metal-binding site 264731004527 Cache domain; Region: Cache_1; pfam02743 264731004528 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 264731004529 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 264731004530 putative active site [active] 264731004531 catalytic site [active] 264731004532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264731004533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004534 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 264731004535 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 264731004536 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 264731004537 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 264731004538 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 264731004539 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264731004540 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264731004541 stage V sporulation protein K; Region: spore_V_K; TIGR02881 264731004542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731004543 Walker A motif; other site 264731004544 ATP binding site [chemical binding]; other site 264731004545 Walker B motif; other site 264731004546 arginine finger; other site 264731004547 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 264731004548 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 264731004549 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 264731004550 active site 264731004551 metal binding site [ion binding]; metal-binding site 264731004552 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264731004553 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 264731004554 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264731004555 CoenzymeA binding site [chemical binding]; other site 264731004556 subunit interaction site [polypeptide binding]; other site 264731004557 PHB binding site; other site 264731004558 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731004559 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731004560 catalytic residues [active] 264731004561 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731004562 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264731004563 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 264731004564 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264731004565 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 264731004566 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264731004567 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731004568 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731004569 SusD family; Region: SusD; pfam07980 264731004570 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731004571 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004572 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731004573 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731004574 GMP synthase; Reviewed; Region: guaA; PRK00074 264731004575 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264731004576 AMP/PPi binding site [chemical binding]; other site 264731004577 candidate oxyanion hole; other site 264731004578 catalytic triad [active] 264731004579 potential glutamine specificity residues [chemical binding]; other site 264731004580 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264731004581 ATP Binding subdomain [chemical binding]; other site 264731004582 Ligand Binding sites [chemical binding]; other site 264731004583 Dimerization subdomain; other site 264731004584 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731004585 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 264731004586 Substrate binding site; other site 264731004587 metal-binding site 264731004588 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004589 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 264731004590 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731004591 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264731004592 active site 264731004593 dimer interface [polypeptide binding]; other site 264731004594 metal binding site [ion binding]; metal-binding site 264731004595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731004596 AMP binding site [chemical binding]; other site 264731004597 active site 264731004598 acyl-activating enzyme (AAE) consensus motif; other site 264731004599 CoA binding site [chemical binding]; other site 264731004600 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 264731004601 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 264731004602 active site 264731004603 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264731004604 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264731004605 substrate binding site [chemical binding]; other site 264731004606 oxyanion hole (OAH) forming residues; other site 264731004607 trimer interface [polypeptide binding]; other site 264731004608 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 264731004609 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 264731004610 dimer interface [polypeptide binding]; other site 264731004611 tetramer interface [polypeptide binding]; other site 264731004612 PYR/PP interface [polypeptide binding]; other site 264731004613 TPP binding site [chemical binding]; other site 264731004614 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 264731004615 TPP-binding site; other site 264731004616 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264731004617 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264731004618 CoenzymeA binding site [chemical binding]; other site 264731004619 subunit interaction site [polypeptide binding]; other site 264731004620 PHB binding site; other site 264731004621 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264731004622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731004623 nucleotide binding site [chemical binding]; other site 264731004624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264731004625 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264731004626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731004627 nucleotide binding site [chemical binding]; other site 264731004628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264731004629 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264731004630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731004631 nucleotide binding site [chemical binding]; other site 264731004632 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264731004633 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264731004634 dimer interface [polypeptide binding]; other site 264731004635 putative anticodon binding site; other site 264731004636 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264731004637 motif 1; other site 264731004638 active site 264731004639 motif 2; other site 264731004640 motif 3; other site 264731004641 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 264731004642 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264731004643 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264731004644 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 264731004645 A new structural DNA glycosylase; Region: AlkD_like; cd06561 264731004646 active site 264731004647 Predicted flavoprotein [General function prediction only]; Region: COG0431 264731004648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264731004649 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264731004650 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264731004651 DNA binding site [nucleotide binding] 264731004652 active site 264731004653 glycerate kinase; Region: TIGR00045 264731004654 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 264731004655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264731004656 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264731004657 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731004658 bile acid transporter; Region: bass; TIGR00841 264731004659 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264731004660 FAD binding site [chemical binding]; other site 264731004661 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 264731004662 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264731004663 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 264731004664 PSP1 C-terminal conserved region; Region: PSP1; cl00770 264731004665 GldH lipoprotein; Region: GldH_lipo; pfam14109 264731004666 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264731004667 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264731004668 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264731004669 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264731004670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264731004671 rod shape-determining protein MreC; Provisional; Region: PRK13922 264731004672 rod shape-determining protein MreC; Region: MreC; pfam04085 264731004673 rod shape-determining protein MreB; Provisional; Region: PRK13927 264731004674 MreB and similar proteins; Region: MreB_like; cd10225 264731004675 nucleotide binding site [chemical binding]; other site 264731004676 Mg binding site [ion binding]; other site 264731004677 putative protofilament interaction site [polypeptide binding]; other site 264731004678 RodZ interaction site [polypeptide binding]; other site 264731004679 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264731004680 purine monophosphate binding site [chemical binding]; other site 264731004681 dimer interface [polypeptide binding]; other site 264731004682 putative catalytic residues [active] 264731004683 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 264731004684 dimer interface [polypeptide binding]; other site 264731004685 active site 264731004686 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264731004687 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264731004688 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264731004689 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264731004690 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264731004691 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264731004692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264731004693 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 264731004694 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 264731004695 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 264731004696 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 264731004697 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264731004698 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264731004699 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 264731004700 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 264731004701 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 264731004702 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 264731004703 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 264731004704 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 264731004705 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 264731004706 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 264731004707 dimerization interface [polypeptide binding]; other site 264731004708 putative active cleft [active] 264731004709 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 264731004710 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 264731004711 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731004712 active site 264731004713 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 264731004714 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 264731004715 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264731004716 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264731004717 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264731004718 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 264731004719 active site 264731004720 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 264731004721 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264731004722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731004723 AAA domain; Region: AAA_21; pfam13304 264731004724 Walker A/P-loop; other site 264731004725 ATP binding site [chemical binding]; other site 264731004726 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 264731004727 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 264731004728 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 264731004729 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 264731004730 oligomer interface [polypeptide binding]; other site 264731004731 active site 264731004732 metal binding site [ion binding]; metal-binding site 264731004733 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 264731004734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731004735 FeS/SAM binding site; other site 264731004736 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264731004737 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264731004738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731004739 ATP binding site [chemical binding]; other site 264731004740 putative Mg++ binding site [ion binding]; other site 264731004741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731004742 nucleotide binding region [chemical binding]; other site 264731004743 ATP-binding site [chemical binding]; other site 264731004744 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264731004745 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264731004746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264731004747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731004748 AAA domain; Region: AAA_23; pfam13476 264731004749 Walker A/P-loop; other site 264731004750 ATP binding site [chemical binding]; other site 264731004751 Q-loop/lid; other site 264731004752 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264731004753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731004754 D-loop; other site 264731004755 H-loop/switch region; other site 264731004756 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264731004757 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264731004758 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 264731004759 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 264731004760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731004761 Walker A motif; other site 264731004762 ATP binding site [chemical binding]; other site 264731004763 Walker B motif; other site 264731004764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264731004765 Integrase core domain; Region: rve; pfam00665 264731004766 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 264731004767 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731004768 extended (e) SDRs; Region: SDR_e; cd08946 264731004769 NAD(P) binding site [chemical binding]; other site 264731004770 active site 264731004771 substrate binding site [chemical binding]; other site 264731004772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004773 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 264731004774 putative ADP-binding pocket [chemical binding]; other site 264731004775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004776 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264731004777 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264731004778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731004779 active site 264731004780 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264731004781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731004782 active site 264731004783 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264731004784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731004786 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264731004787 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264731004788 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731004789 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264731004790 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 264731004791 active site 264731004792 catalytic site [active] 264731004793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731004794 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264731004795 active site 264731004796 nucleotide binding site [chemical binding]; other site 264731004797 HIGH motif; other site 264731004798 KMSKS motif; other site 264731004799 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264731004800 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264731004801 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264731004802 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264731004803 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 264731004804 Substrate binding site; other site 264731004805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731004806 AAA domain; Region: AAA_21; pfam13304 264731004807 Walker A/P-loop; other site 264731004808 ATP binding site [chemical binding]; other site 264731004809 AAA domain; Region: AAA_21; pfam13304 264731004810 AAA domain; Region: AAA_25; pfam13481 264731004811 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264731004812 Walker B motif; other site 264731004813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 264731004814 DNA binding site [nucleotide binding] 264731004815 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731004816 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731004817 amidase catalytic site [active] 264731004818 Zn binding residues [ion binding]; other site 264731004819 substrate binding site [chemical binding]; other site 264731004820 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264731004821 SLBB domain; Region: SLBB; pfam10531 264731004822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731004823 motif I; other site 264731004824 active site 264731004825 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 264731004826 Chain length determinant protein; Region: Wzz; cl15801 264731004827 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 264731004828 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264731004829 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 264731004830 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 264731004831 transcriptional activator RfaH; Region: RfaH; TIGR01955 264731004832 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 264731004833 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264731004834 active site 264731004835 dimer interface [polypeptide binding]; other site 264731004836 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264731004837 dimer interface [polypeptide binding]; other site 264731004838 active site 264731004839 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264731004840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731004841 motif II; other site 264731004842 Transposase IS200 like; Region: Y1_Tnp; cl00848 264731004843 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 264731004844 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 264731004845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731004847 dimer interface [polypeptide binding]; other site 264731004848 phosphorylation site [posttranslational modification] 264731004849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004850 ATP binding site [chemical binding]; other site 264731004851 Mg2+ binding site [ion binding]; other site 264731004852 G-X-G motif; other site 264731004853 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264731004854 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 264731004855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731004856 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264731004857 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 264731004858 DNA binding residues [nucleotide binding] 264731004859 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 264731004860 PA14 domain; Region: PA14; cl08459 264731004861 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 264731004862 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 264731004863 putative active site [active] 264731004864 putative catalytic site [active] 264731004865 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731004866 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731004867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004869 ATP binding site [chemical binding]; other site 264731004870 Mg2+ binding site [ion binding]; other site 264731004871 G-X-G motif; other site 264731004872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264731004873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264731004874 DNA binding site [nucleotide binding] 264731004875 domain linker motif; other site 264731004876 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264731004877 dimerization interface [polypeptide binding]; other site 264731004878 ligand binding site [chemical binding]; other site 264731004879 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731004880 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264731004881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731004882 motif II; other site 264731004883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264731004884 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 264731004885 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731004886 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731004887 active site 264731004888 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 264731004889 PAS fold; Region: PAS_3; pfam08447 264731004890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731004891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731004892 dimer interface [polypeptide binding]; other site 264731004893 phosphorylation site [posttranslational modification] 264731004894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731004895 ATP binding site [chemical binding]; other site 264731004896 Mg2+ binding site [ion binding]; other site 264731004897 G-X-G motif; other site 264731004898 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 264731004899 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264731004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264731004901 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 264731004902 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 264731004903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731004904 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264731004905 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264731004906 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 264731004907 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264731004908 Predicted membrane protein [Function unknown]; Region: COG1238 264731004909 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 264731004910 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264731004911 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 264731004912 NodB motif; other site 264731004913 putative active site [active] 264731004914 putative catalytic site [active] 264731004915 putative Zn binding site [ion binding]; other site 264731004916 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264731004917 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731004918 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731004919 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 264731004920 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264731004921 phosphate binding site [ion binding]; other site 264731004922 4Fe-4S binding domain; Region: Fer4; pfam00037 264731004923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731004924 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 264731004925 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 264731004926 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 264731004927 putative DNA binding site [nucleotide binding]; other site 264731004928 putative Zn2+ binding site [ion binding]; other site 264731004929 AsnC family; Region: AsnC_trans_reg; pfam01037 264731004930 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264731004931 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264731004932 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264731004933 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264731004934 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264731004935 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264731004936 active site 264731004937 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264731004938 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264731004939 substrate binding pocket [chemical binding]; other site 264731004940 chain length determination region; other site 264731004941 substrate-Mg2+ binding site; other site 264731004942 catalytic residues [active] 264731004943 aspartate-rich region 1; other site 264731004944 active site lid residues [active] 264731004945 aspartate-rich region 2; other site 264731004946 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264731004947 cytidylate kinase; Provisional; Region: cmk; PRK00023 264731004948 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264731004949 active site 264731004950 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264731004951 CMP-binding site; other site 264731004952 The sites determining sugar specificity; other site 264731004953 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 264731004954 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264731004955 catalytic center binding site [active] 264731004956 ATP binding site [chemical binding]; other site 264731004957 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264731004958 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 264731004959 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264731004960 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 264731004961 RNA binding site [nucleotide binding]; other site 264731004962 active site 264731004963 Bacitracin resistance protein BacA; Region: BacA; pfam02673 264731004964 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 264731004965 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 264731004966 FtsX-like permease family; Region: FtsX; pfam02687 264731004967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731004968 FeS/SAM binding site; other site 264731004969 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264731004970 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264731004971 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264731004972 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731004973 active site 264731004974 NTP binding site [chemical binding]; other site 264731004975 metal binding triad [ion binding]; metal-binding site 264731004976 antibiotic binding site [chemical binding]; other site 264731004977 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264731004978 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731004979 Walker A motif; other site 264731004980 ATP binding site [chemical binding]; other site 264731004981 Walker B motif; other site 264731004982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 264731004983 DNA binding site [nucleotide binding] 264731004984 domain linker motif; other site 264731004985 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731004986 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731004987 amidase catalytic site [active] 264731004988 Zn binding residues [ion binding]; other site 264731004989 substrate binding site [chemical binding]; other site 264731004990 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264731004991 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264731004992 putative trimer interface [polypeptide binding]; other site 264731004993 putative CoA binding site [chemical binding]; other site 264731004994 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264731004995 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731004996 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731004997 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731004998 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731004999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 264731005000 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 264731005001 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 264731005002 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 264731005003 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264731005004 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 264731005005 active site 264731005006 NTP binding site [chemical binding]; other site 264731005007 metal binding triad [ion binding]; metal-binding site 264731005008 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264731005009 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731005010 Zn2+ binding site [ion binding]; other site 264731005011 Mg2+ binding site [ion binding]; other site 264731005012 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 264731005013 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264731005014 amino acid carrier protein; Region: agcS; TIGR00835 264731005015 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 264731005016 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 264731005017 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 264731005018 DoxX; Region: DoxX; pfam07681 264731005019 triosephosphate isomerase; Provisional; Region: PRK14567 264731005020 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264731005021 substrate binding site [chemical binding]; other site 264731005022 dimer interface [polypeptide binding]; other site 264731005023 catalytic triad [active] 264731005024 Sporulation related domain; Region: SPOR; pfam05036 264731005025 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 264731005026 homodecamer interface [polypeptide binding]; other site 264731005027 GTP cyclohydrolase I; Provisional; Region: PLN03044 264731005028 active site 264731005029 putative catalytic site residues [active] 264731005030 zinc binding site [ion binding]; other site 264731005031 GTP-CH-I/GFRP interaction surface; other site 264731005032 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 264731005033 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 264731005034 active site 264731005035 putative alpha-glucosidase; Provisional; Region: PRK10658 264731005036 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 264731005037 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 264731005038 putative active site [active] 264731005039 putative catalytic site [active] 264731005040 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264731005041 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264731005042 thymidine kinase; Provisional; Region: PRK04296 264731005043 Predicted methyltransferases [General function prediction only]; Region: COG0313 264731005044 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264731005045 putative SAM binding site [chemical binding]; other site 264731005046 putative homodimer interface [polypeptide binding]; other site 264731005047 USP8 interacting; Region: USP8_interact; pfam08941 264731005048 Protease prsW family; Region: PrsW-protease; pfam13367 264731005049 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 264731005050 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005051 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005052 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005054 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005055 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005056 AAA domain; Region: AAA_22; pfam13401 264731005057 AAA domain; Region: AAA_14; pfam13173 264731005058 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 264731005059 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731005060 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731005061 active site 264731005062 NTP binding site [chemical binding]; other site 264731005063 metal binding triad [ion binding]; metal-binding site 264731005064 antibiotic binding site [chemical binding]; other site 264731005065 HEPN domain; Region: HEPN; cl00824 264731005066 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264731005067 Catalytic site [active] 264731005068 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 264731005069 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 264731005070 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 264731005071 catalytic residues [active] 264731005072 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005073 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005074 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005075 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731005076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005077 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731005078 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731005079 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005080 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005081 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005082 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005083 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005084 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005085 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264731005086 nucleoside/Zn binding site; other site 264731005087 dimer interface [polypeptide binding]; other site 264731005088 catalytic motif [active] 264731005089 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 264731005090 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 264731005091 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264731005092 putative nucleotide binding site [chemical binding]; other site 264731005093 uridine monophosphate binding site [chemical binding]; other site 264731005094 homohexameric interface [polypeptide binding]; other site 264731005095 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264731005096 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264731005097 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 264731005098 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264731005099 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 264731005100 active site 264731005101 PHP Thumb interface [polypeptide binding]; other site 264731005102 metal binding site [ion binding]; metal-binding site 264731005103 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264731005104 generic binding surface II; other site 264731005105 generic binding surface I; other site 264731005106 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264731005107 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731005108 catalytic residues [active] 264731005109 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 264731005110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731005111 Response regulator receiver domain; Region: Response_reg; pfam00072 264731005112 active site 264731005113 phosphorylation site [posttranslational modification] 264731005114 intermolecular recognition site; other site 264731005115 dimerization interface [polypeptide binding]; other site 264731005116 PglZ domain; Region: PglZ; pfam08665 264731005117 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 264731005118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005119 TPR motif; other site 264731005120 binding surface 264731005121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731005122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005123 binding surface 264731005124 TPR motif; other site 264731005125 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 264731005126 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264731005127 hinge; other site 264731005128 active site 264731005129 Pectic acid lyase; Region: Pec_lyase; pfam09492 264731005130 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 264731005131 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731005132 Predicted permeases [General function prediction only]; Region: COG0795 264731005133 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264731005134 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264731005135 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264731005136 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 264731005137 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264731005138 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264731005139 dimerization interface [polypeptide binding]; other site 264731005140 active site 264731005141 aspartate aminotransferase; Provisional; Region: PRK05764 264731005142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731005143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731005144 homodimer interface [polypeptide binding]; other site 264731005145 catalytic residue [active] 264731005146 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264731005147 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264731005148 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264731005149 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264731005150 PBP superfamily domain; Region: PBP_like_2; pfam12849 264731005151 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 264731005152 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264731005153 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731005154 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264731005155 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 264731005156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731005157 active site 264731005158 metal binding site [ion binding]; metal-binding site 264731005159 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264731005160 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264731005161 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 264731005162 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 264731005163 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 264731005164 Outer membrane efflux protein; Region: OEP; pfam02321 264731005165 Outer membrane efflux protein; Region: OEP; pfam02321 264731005166 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731005167 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731005168 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731005169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005170 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264731005171 FtsX-like permease family; Region: FtsX; pfam02687 264731005172 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005173 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264731005174 FtsX-like permease family; Region: FtsX; pfam02687 264731005175 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264731005176 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264731005177 Walker A/P-loop; other site 264731005178 ATP binding site [chemical binding]; other site 264731005179 Q-loop/lid; other site 264731005180 ABC transporter signature motif; other site 264731005181 Walker B; other site 264731005182 D-loop; other site 264731005183 H-loop/switch region; other site 264731005184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264731005185 DNA-binding site [nucleotide binding]; DNA binding site 264731005186 Domain of unknown function (DUF4220); Region: DUF4220; pfam13968 264731005187 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264731005188 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264731005189 Walker A/P-loop; other site 264731005190 ATP binding site [chemical binding]; other site 264731005191 Q-loop/lid; other site 264731005192 ABC transporter signature motif; other site 264731005193 Walker B; other site 264731005194 D-loop; other site 264731005195 H-loop/switch region; other site 264731005196 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731005197 PA14 domain; Region: PA14; cl08459 264731005198 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731005199 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 264731005200 ATP-NAD kinase; Region: NAD_kinase; pfam01513 264731005201 DJ-1 family protein; Region: not_thiJ; TIGR01383 264731005202 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 264731005203 conserved cys residue [active] 264731005204 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264731005205 substrate binding site; other site 264731005206 dimer interface; other site 264731005207 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264731005208 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264731005209 generic binding surface II; other site 264731005210 ssDNA binding site; other site 264731005211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731005212 ATP binding site [chemical binding]; other site 264731005213 putative Mg++ binding site [ion binding]; other site 264731005214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731005215 nucleotide binding region [chemical binding]; other site 264731005216 ATP-binding site [chemical binding]; other site 264731005217 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264731005218 NlpC/P60 family; Region: NLPC_P60; pfam00877 264731005219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264731005220 Peptidase family M23; Region: Peptidase_M23; pfam01551 264731005221 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264731005222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264731005223 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 264731005224 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264731005225 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 264731005226 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 264731005227 RmuC family; Region: RmuC; pfam02646 264731005228 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005229 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005230 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005231 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731005232 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005233 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731005234 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731005235 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731005236 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 264731005237 active site 264731005238 catalytic residues [active] 264731005239 CotH protein; Region: CotH; pfam08757 264731005240 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264731005241 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731005242 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731005243 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 264731005244 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 264731005245 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264731005246 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264731005247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264731005248 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264731005249 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 264731005250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731005251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264731005252 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 264731005253 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 264731005254 active site 264731005255 dimer interface [polypeptide binding]; other site 264731005256 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 264731005257 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264731005258 active site 264731005259 FMN binding site [chemical binding]; other site 264731005260 substrate binding site [chemical binding]; other site 264731005261 3Fe-4S cluster binding site [ion binding]; other site 264731005262 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 264731005263 domain interface; other site 264731005264 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 264731005265 Prophage antirepressor [Transcription]; Region: COG3617 264731005266 BRO family, N-terminal domain; Region: Bro-N; smart01040 264731005267 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 264731005268 HipA N-terminal domain; Region: Couple_hipA; pfam13657 264731005269 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264731005270 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264731005271 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731005272 CTP synthetase; Validated; Region: pyrG; PRK05380 264731005273 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264731005274 Catalytic site [active] 264731005275 active site 264731005276 UTP binding site [chemical binding]; other site 264731005277 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264731005278 active site 264731005279 putative oxyanion hole; other site 264731005280 catalytic triad [active] 264731005281 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 264731005282 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 264731005283 active site 264731005284 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 264731005285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731005287 homodimer interface [polypeptide binding]; other site 264731005288 catalytic residue [active] 264731005289 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 264731005290 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264731005291 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 264731005292 asparagine synthetase B; Provisional; Region: asnB; PRK09431 264731005293 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 264731005294 active site 264731005295 dimer interface [polypeptide binding]; other site 264731005296 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 264731005297 Ligand Binding Site [chemical binding]; other site 264731005298 Molecular Tunnel; other site 264731005299 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264731005300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264731005301 Walker A/P-loop; other site 264731005302 ATP binding site [chemical binding]; other site 264731005303 Q-loop/lid; other site 264731005304 ABC transporter signature motif; other site 264731005305 Walker B; other site 264731005306 D-loop; other site 264731005307 H-loop/switch region; other site 264731005308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005309 FtsX-like permease family; Region: FtsX; pfam02687 264731005310 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005311 FtsX-like permease family; Region: FtsX; pfam02687 264731005312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005313 FtsX-like permease family; Region: FtsX; pfam02687 264731005314 FtsX-like permease family; Region: FtsX; pfam02687 264731005315 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 264731005316 FtsX-like permease family; Region: FtsX; pfam02687 264731005317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005318 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 264731005319 FtsX-like permease family; Region: FtsX; pfam02687 264731005320 FtsX-like permease family; Region: FtsX; pfam02687 264731005321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731005322 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731005323 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731005324 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264731005325 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 264731005326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731005327 active site 264731005328 phosphorylation site [posttranslational modification] 264731005329 intermolecular recognition site; other site 264731005330 dimerization interface [polypeptide binding]; other site 264731005331 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264731005332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731005333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731005334 ATP binding site [chemical binding]; other site 264731005335 G-X-G motif; other site 264731005336 AAA domain; Region: AAA_30; pfam13604 264731005337 Family description; Region: UvrD_C_2; pfam13538 264731005338 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 264731005339 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 264731005340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731005341 S-adenosylmethionine binding site [chemical binding]; other site 264731005342 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 264731005343 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 264731005344 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264731005345 putative active site [active] 264731005346 catalytic site [active] 264731005347 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 264731005348 putative active site [active] 264731005349 catalytic site [active] 264731005350 DNA primase, catalytic core; Region: dnaG; TIGR01391 264731005351 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264731005352 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264731005353 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264731005354 active site 264731005355 metal binding site [ion binding]; metal-binding site 264731005356 interdomain interaction site; other site 264731005357 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264731005358 L-aspartate oxidase; Provisional; Region: PRK09077 264731005359 L-aspartate oxidase; Provisional; Region: PRK06175 264731005360 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264731005361 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005362 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264731005363 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 264731005364 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264731005365 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 264731005366 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 264731005367 phosphoserine phosphatase SerB; Region: serB; TIGR00338 264731005368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731005369 motif II; other site 264731005370 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264731005371 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264731005372 minor groove reading motif; other site 264731005373 helix-hairpin-helix signature motif; other site 264731005374 substrate binding pocket [chemical binding]; other site 264731005375 active site 264731005376 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264731005377 DNA binding and oxoG recognition site [nucleotide binding] 264731005378 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 264731005379 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264731005380 nucleotide binding site [chemical binding]; other site 264731005381 SulA interaction site; other site 264731005382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005383 binding surface 264731005384 TPR repeat; Region: TPR_11; pfam13414 264731005385 TPR motif; other site 264731005386 TPR repeat; Region: TPR_11; pfam13414 264731005387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005388 TPR motif; other site 264731005389 binding surface 264731005390 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264731005391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731005392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005393 binding surface 264731005394 TPR motif; other site 264731005395 TPR repeat; Region: TPR_11; pfam13414 264731005396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731005397 TPR motif; other site 264731005398 binding surface 264731005399 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 264731005400 catalytic motif [active] 264731005401 Catalytic residue [active] 264731005402 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 264731005403 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 264731005404 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 264731005405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264731005406 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 264731005407 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264731005408 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264731005409 Protease prsW family; Region: PrsW-protease; pfam13367 264731005410 Protein of unknown function (DUF805); Region: DUF805; pfam05656 264731005411 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264731005412 substrate binding site [chemical binding]; other site 264731005413 activation loop (A-loop); other site 264731005414 Protein phosphatase 2C; Region: PP2C_2; pfam13672 264731005415 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264731005416 metal ion-dependent adhesion site (MIDAS); other site 264731005417 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264731005418 metal ion-dependent adhesion site (MIDAS); other site 264731005419 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 264731005420 metal ion-dependent adhesion site (MIDAS); other site 264731005421 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264731005422 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264731005423 putative metal binding site [ion binding]; other site 264731005424 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 264731005425 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264731005426 putative metal binding site [ion binding]; other site 264731005427 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264731005428 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264731005429 putative metal binding site [ion binding]; other site 264731005430 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731005431 active site 264731005432 NTP binding site [chemical binding]; other site 264731005433 metal binding triad [ion binding]; metal-binding site 264731005434 hypothetical protein; Region: PHA00684 264731005435 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731005436 VirE N-terminal domain; Region: VirE_N; pfam08800 264731005437 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731005438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264731005439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264731005440 active site 264731005441 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 264731005442 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264731005443 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264731005444 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264731005445 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264731005446 Ligand binding site [chemical binding]; other site 264731005447 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264731005448 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264731005449 Protein of unknown function, DUF486; Region: DUF486; cl01236 264731005450 cell surface protein SprA; Region: surface_SprA; TIGR04189 264731005451 Motility related/secretion protein; Region: SprA_N; pfam14349 264731005452 Motility related/secretion protein; Region: SprA_N; pfam14349 264731005453 Motility related/secretion protein; Region: SprA_N; pfam14349 264731005454 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264731005455 RuvA N terminal domain; Region: RuvA_N; pfam01330 264731005456 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264731005457 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 264731005458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264731005459 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 264731005460 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264731005461 active site 264731005462 substrate binding site [chemical binding]; other site 264731005463 cosubstrate binding site; other site 264731005464 catalytic site [active] 264731005465 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 264731005466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731005467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264731005468 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264731005469 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 264731005470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731005471 catalytic residue [active] 264731005472 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 264731005473 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264731005474 tetramer interface [polypeptide binding]; other site 264731005475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731005476 catalytic residue [active] 264731005477 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264731005478 lipoyl attachment site [posttranslational modification]; other site 264731005479 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264731005480 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264731005481 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264731005482 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264731005483 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 264731005484 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 264731005485 amphipathic channel; other site 264731005486 Asn-Pro-Ala signature motifs; other site 264731005487 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 264731005488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731005489 putative substrate translocation pore; other site 264731005490 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731005491 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731005492 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731005493 catalytic residues [active] 264731005494 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264731005495 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264731005496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264731005497 HlyD family secretion protein; Region: HlyD_3; pfam13437 264731005498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264731005499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264731005500 Walker A/P-loop; other site 264731005501 ATP binding site [chemical binding]; other site 264731005502 Q-loop/lid; other site 264731005503 ABC transporter signature motif; other site 264731005504 Walker B; other site 264731005505 D-loop; other site 264731005506 H-loop/switch region; other site 264731005507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731005508 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264731005509 FtsX-like permease family; Region: FtsX; pfam02687 264731005510 Histidine kinase; Region: His_kinase; pfam06580 264731005511 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264731005512 ATP binding site [chemical binding]; other site 264731005513 Mg2+ binding site [ion binding]; other site 264731005514 G-X-G motif; other site 264731005515 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264731005516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731005517 active site 264731005518 phosphorylation site [posttranslational modification] 264731005519 intermolecular recognition site; other site 264731005520 dimerization interface [polypeptide binding]; other site 264731005521 LytTr DNA-binding domain; Region: LytTR; smart00850 264731005522 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264731005523 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 264731005524 intersubunit interface [polypeptide binding]; other site 264731005525 active site 264731005526 zinc binding site [ion binding]; other site 264731005527 Na+ binding site [ion binding]; other site 264731005528 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 264731005529 substrate binding site [chemical binding]; other site 264731005530 active site 264731005531 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 264731005532 ligand binding site [chemical binding]; other site 264731005533 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264731005534 homodimer interaction site [polypeptide binding]; other site 264731005535 cofactor binding site; other site 264731005536 Peptidase C10 family; Region: Peptidase_C10; pfam01640 264731005537 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731005538 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264731005539 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 264731005540 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264731005541 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 264731005542 hexamer interface [polypeptide binding]; other site 264731005543 ligand binding site [chemical binding]; other site 264731005544 putative active site [active] 264731005545 NAD(P) binding site [chemical binding]; other site 264731005546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264731005547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 264731005548 intermolecular recognition site; other site 264731005549 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264731005550 Cache domain; Region: Cache_1; pfam02743 264731005551 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 264731005552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731005553 dimerization interface [polypeptide binding]; other site 264731005554 Cache domain; Region: Cache_1; pfam02743 264731005555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731005556 dimerization interface [polypeptide binding]; other site 264731005557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731005558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731005559 dimer interface [polypeptide binding]; other site 264731005560 phosphorylation site [posttranslational modification] 264731005561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731005562 ATP binding site [chemical binding]; other site 264731005563 Mg2+ binding site [ion binding]; other site 264731005564 G-X-G motif; other site 264731005565 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264731005566 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264731005567 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264731005568 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 264731005569 putative substrate binding site [chemical binding]; other site 264731005570 active site 264731005571 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731005572 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731005573 SusD family; Region: SusD; pfam07980 264731005574 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005576 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005577 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731005578 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731005579 active site 264731005580 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731005581 Two component regulator propeller; Region: Reg_prop; pfam07494 264731005582 Two component regulator propeller; Region: Reg_prop; pfam07494 264731005583 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731005584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731005585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731005586 dimer interface [polypeptide binding]; other site 264731005587 phosphorylation site [posttranslational modification] 264731005588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731005589 ATP binding site [chemical binding]; other site 264731005590 Mg2+ binding site [ion binding]; other site 264731005591 G-X-G motif; other site 264731005592 Response regulator receiver domain; Region: Response_reg; pfam00072 264731005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731005594 active site 264731005595 phosphorylation site [posttranslational modification] 264731005596 intermolecular recognition site; other site 264731005597 dimerization interface [polypeptide binding]; other site 264731005598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731005599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731005600 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264731005601 dimer interface [polypeptide binding]; other site 264731005602 catalytic triad [active] 264731005603 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 264731005604 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264731005605 homodimer interface [polypeptide binding]; other site 264731005606 substrate-cofactor binding pocket; other site 264731005607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731005608 catalytic residue [active] 264731005609 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005610 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005611 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731005612 Histidine kinase; Region: His_kinase; pfam06580 264731005613 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264731005614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731005615 Response regulator receiver domain; Region: Response_reg; pfam00072 264731005616 active site 264731005617 phosphorylation site [posttranslational modification] 264731005618 intermolecular recognition site; other site 264731005619 dimerization interface [polypeptide binding]; other site 264731005620 LytTr DNA-binding domain; Region: LytTR; smart00850 264731005621 glutamate dehydrogenase; Provisional; Region: PRK14030 264731005622 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264731005623 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 264731005624 NAD(P) binding site [chemical binding]; other site 264731005625 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 264731005626 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264731005627 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264731005628 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264731005629 alphaNTD - beta interaction site [polypeptide binding]; other site 264731005630 alphaNTD homodimer interface [polypeptide binding]; other site 264731005631 alphaNTD - beta' interaction site [polypeptide binding]; other site 264731005632 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264731005633 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264731005634 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264731005635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731005636 RNA binding surface [nucleotide binding]; other site 264731005637 30S ribosomal protein S11; Validated; Region: PRK05309 264731005638 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264731005639 30S ribosomal protein S13; Region: bact_S13; TIGR03631 264731005640 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 264731005641 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264731005642 rRNA binding site [nucleotide binding]; other site 264731005643 predicted 30S ribosome binding site; other site 264731005644 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264731005645 active site 264731005646 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264731005647 SecY translocase; Region: SecY; pfam00344 264731005648 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264731005649 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264731005650 23S rRNA binding site [nucleotide binding]; other site 264731005651 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264731005652 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264731005653 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264731005654 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264731005655 23S rRNA interface [nucleotide binding]; other site 264731005656 5S rRNA interface [nucleotide binding]; other site 264731005657 L27 interface [polypeptide binding]; other site 264731005658 L5 interface [polypeptide binding]; other site 264731005659 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264731005660 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264731005661 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264731005662 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264731005663 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 264731005664 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264731005665 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264731005666 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264731005667 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264731005668 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264731005669 RNA binding site [nucleotide binding]; other site 264731005670 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264731005671 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264731005672 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264731005673 23S rRNA interface [nucleotide binding]; other site 264731005674 putative translocon interaction site; other site 264731005675 signal recognition particle (SRP54) interaction site; other site 264731005676 L23 interface [polypeptide binding]; other site 264731005677 trigger factor interaction site; other site 264731005678 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264731005679 23S rRNA interface [nucleotide binding]; other site 264731005680 5S rRNA interface [nucleotide binding]; other site 264731005681 putative antibiotic binding site [chemical binding]; other site 264731005682 L25 interface [polypeptide binding]; other site 264731005683 L27 interface [polypeptide binding]; other site 264731005684 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264731005685 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264731005686 G-X-X-G motif; other site 264731005687 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264731005688 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264731005689 putative translocon binding site; other site 264731005690 protein-rRNA interface [nucleotide binding]; other site 264731005691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264731005692 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264731005693 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264731005694 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264731005695 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264731005696 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264731005697 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 264731005698 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 264731005699 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 264731005700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264731005701 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264731005702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264731005703 Walker A/P-loop; other site 264731005704 ATP binding site [chemical binding]; other site 264731005705 Q-loop/lid; other site 264731005706 ABC transporter signature motif; other site 264731005707 Walker B; other site 264731005708 D-loop; other site 264731005709 H-loop/switch region; other site 264731005710 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 264731005711 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 264731005712 Catalytic site [active] 264731005713 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 264731005714 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005715 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731005716 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 264731005717 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264731005718 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264731005719 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731005720 Penicillinase repressor; Region: Pencillinase_R; pfam03965 264731005721 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264731005722 elongation factor G; Reviewed; Region: PRK12739 264731005723 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264731005724 G1 box; other site 264731005725 putative GEF interaction site [polypeptide binding]; other site 264731005726 GTP/Mg2+ binding site [chemical binding]; other site 264731005727 Switch I region; other site 264731005728 G2 box; other site 264731005729 G3 box; other site 264731005730 Switch II region; other site 264731005731 G4 box; other site 264731005732 G5 box; other site 264731005733 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264731005734 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264731005735 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264731005736 30S ribosomal protein S7; Validated; Region: PRK05302 264731005737 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264731005738 S17 interaction site [polypeptide binding]; other site 264731005739 S8 interaction site; other site 264731005740 16S rRNA interaction site [nucleotide binding]; other site 264731005741 streptomycin interaction site [chemical binding]; other site 264731005742 23S rRNA interaction site [nucleotide binding]; other site 264731005743 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264731005744 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264731005745 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264731005746 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 264731005747 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264731005748 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264731005749 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 264731005750 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264731005751 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264731005752 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264731005753 DNA binding site [nucleotide binding] 264731005754 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264731005755 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 264731005756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264731005757 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264731005758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264731005759 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 264731005760 RPB12 interaction site [polypeptide binding]; other site 264731005761 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264731005762 RPB3 interaction site [polypeptide binding]; other site 264731005763 RPB1 interaction site [polypeptide binding]; other site 264731005764 RPB11 interaction site [polypeptide binding]; other site 264731005765 RPB10 interaction site [polypeptide binding]; other site 264731005766 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264731005767 core dimer interface [polypeptide binding]; other site 264731005768 peripheral dimer interface [polypeptide binding]; other site 264731005769 L10 interface [polypeptide binding]; other site 264731005770 L11 interface [polypeptide binding]; other site 264731005771 putative EF-Tu interaction site [polypeptide binding]; other site 264731005772 putative EF-G interaction site [polypeptide binding]; other site 264731005773 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264731005774 23S rRNA interface [nucleotide binding]; other site 264731005775 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264731005776 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264731005777 mRNA/rRNA interface [nucleotide binding]; other site 264731005778 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264731005779 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264731005780 23S rRNA interface [nucleotide binding]; other site 264731005781 L7/L12 interface [polypeptide binding]; other site 264731005782 putative thiostrepton binding site; other site 264731005783 L25 interface [polypeptide binding]; other site 264731005784 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264731005785 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264731005786 putative homodimer interface [polypeptide binding]; other site 264731005787 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264731005788 heterodimer interface [polypeptide binding]; other site 264731005789 homodimer interface [polypeptide binding]; other site 264731005790 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 264731005791 elongation factor Tu; Reviewed; Region: PRK12735 264731005792 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264731005793 G1 box; other site 264731005794 GEF interaction site [polypeptide binding]; other site 264731005795 GTP/Mg2+ binding site [chemical binding]; other site 264731005796 Switch I region; other site 264731005797 G2 box; other site 264731005798 G3 box; other site 264731005799 Switch II region; other site 264731005800 G4 box; other site 264731005801 G5 box; other site 264731005802 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264731005803 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264731005804 Antibiotic Binding Site [chemical binding]; other site 264731005805 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264731005806 30S subunit binding site; other site 264731005807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264731005808 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 264731005809 active site 264731005810 DNA binding site [nucleotide binding] 264731005811 Int/Topo IB signature motif; other site 264731005812 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 264731005813 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 264731005814 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264731005815 active site 264731005816 NTP binding site [chemical binding]; other site 264731005817 metal binding triad [ion binding]; metal-binding site 264731005818 antibiotic binding site [chemical binding]; other site 264731005819 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 264731005820 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264731005821 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731005822 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731005823 catalytic residues [active] 264731005824 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264731005825 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264731005826 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264731005827 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 264731005828 active site 264731005829 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 264731005830 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 264731005831 NAD(P) binding site [chemical binding]; other site 264731005832 LDH/MDH dimer interface [polypeptide binding]; other site 264731005833 substrate binding site [chemical binding]; other site 264731005834 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 264731005835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731005836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731005837 DNA binding residues [nucleotide binding] 264731005838 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005839 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731005840 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264731005841 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 264731005842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264731005843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264731005844 trimer interface [polypeptide binding]; other site 264731005845 putative metal binding site [ion binding]; other site 264731005846 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264731005847 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731005848 putative active site [active] 264731005849 putative metal binding site [ion binding]; other site 264731005850 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 264731005851 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264731005852 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264731005853 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264731005854 HIGH motif; other site 264731005855 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264731005856 active site 264731005857 KMSKS motif; other site 264731005858 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 264731005859 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 264731005860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264731005861 Zn2+ binding site [ion binding]; other site 264731005862 Mg2+ binding site [ion binding]; other site 264731005863 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 264731005864 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 264731005865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731005866 ATP binding site [chemical binding]; other site 264731005867 putative Mg++ binding site [ion binding]; other site 264731005868 helicase superfamily c-terminal domain; Region: HELICc; smart00490 264731005869 nucleotide binding region [chemical binding]; other site 264731005870 ATP-binding site [chemical binding]; other site 264731005871 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731005872 gliding motility associated protien GldN; Region: GldN; TIGR03523 264731005873 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 264731005874 GldM N-terminal domain; Region: GldM_N; pfam12081 264731005875 GldM C-terminal domain; Region: GldM_C; pfam12080 264731005876 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 264731005877 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 264731005878 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 264731005879 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264731005880 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 264731005881 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264731005882 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 264731005883 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 264731005884 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731005885 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731005886 Predicted transcriptional regulators [Transcription]; Region: COG1695 264731005887 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 264731005888 PspC domain; Region: PspC; pfam04024 264731005889 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 264731005890 active site 264731005891 catalytic site [active] 264731005892 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 264731005893 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 264731005894 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264731005895 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02763 264731005896 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 264731005897 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 264731005898 trimer interface [polypeptide binding]; other site 264731005899 active site 264731005900 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 264731005901 catalytic site [active] 264731005902 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 264731005903 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 264731005904 active site 264731005905 catalytic site [active] 264731005906 SusE outer membrane protein; Region: SusE; pfam14292 264731005907 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731005908 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005909 SusD family; Region: SusD; pfam07980 264731005910 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005911 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005912 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005913 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 264731005914 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 264731005915 Arginine repressor [Transcription]; Region: ArgR; COG1438 264731005916 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 264731005917 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 264731005918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 264731005919 Coenzyme A binding pocket [chemical binding]; other site 264731005920 argininosuccinate synthase; Provisional; Region: PRK13820 264731005921 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264731005922 Ligand Binding Site [chemical binding]; other site 264731005923 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 264731005924 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264731005925 acetylornithine aminotransferase; Provisional; Region: PRK02627 264731005926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264731005927 inhibitor-cofactor binding pocket; inhibition site 264731005928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731005929 catalytic residue [active] 264731005930 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 264731005931 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 264731005932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264731005933 non-specific DNA binding site [nucleotide binding]; other site 264731005934 salt bridge; other site 264731005935 sequence-specific DNA binding site [nucleotide binding]; other site 264731005936 Cupin domain; Region: Cupin_2; pfam07883 264731005937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731005938 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264731005939 acyl-activating enzyme (AAE) consensus motif; other site 264731005940 AMP binding site [chemical binding]; other site 264731005941 active site 264731005942 CoA binding site [chemical binding]; other site 264731005943 hypothetical protein; Reviewed; Region: PRK12497 264731005944 gamma-glutamyl kinase; Provisional; Region: PRK05429 264731005945 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264731005946 nucleotide binding site [chemical binding]; other site 264731005947 homotetrameric interface [polypeptide binding]; other site 264731005948 putative phosphate binding site [ion binding]; other site 264731005949 putative allosteric binding site; other site 264731005950 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264731005951 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 264731005952 putative catalytic cysteine [active] 264731005953 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731005954 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731005955 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 264731005956 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264731005957 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264731005958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731005959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731005960 ATP binding site [chemical binding]; other site 264731005961 Mg2+ binding site [ion binding]; other site 264731005962 G-X-G motif; other site 264731005963 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264731005964 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731005965 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 264731005966 active site 264731005967 catalytic triad [active] 264731005968 oxyanion hole [active] 264731005969 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 264731005970 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 264731005971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264731005972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731005973 catalytic residue [active] 264731005974 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264731005975 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731005976 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 264731005977 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731005978 translocation protein TolB; Provisional; Region: tolB; PRK02889 264731005979 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731005980 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005981 SusD family; Region: SusD; pfam07980 264731005982 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005983 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005984 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005985 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731005986 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731005987 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005988 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731005989 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005990 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005991 SusD family; Region: SusD; pfam07980 264731005992 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731005993 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731005994 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731005995 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731005996 SusD family; Region: SusD; pfam07980 264731005997 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 264731005998 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 264731005999 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 264731006000 active site 264731006001 catalytic site [active] 264731006002 NigD-like protein; Region: NigD; pfam12667 264731006003 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 264731006004 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264731006005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264731006006 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264731006007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731006008 RNA binding surface [nucleotide binding]; other site 264731006009 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264731006010 active site 264731006011 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264731006012 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 264731006013 elongation factor P; Validated; Region: PRK00529 264731006014 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264731006015 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264731006016 RNA binding site [nucleotide binding]; other site 264731006017 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264731006018 RNA binding site [nucleotide binding]; other site 264731006019 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264731006020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264731006021 active site 264731006022 hypothetical protein; Reviewed; Region: PRK00024 264731006023 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264731006024 MPN+ (JAMM) motif; other site 264731006025 Zinc-binding site [ion binding]; other site 264731006026 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264731006027 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 264731006028 Double zinc ribbon; Region: DZR; pfam12773 264731006029 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731006030 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 264731006031 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264731006032 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264731006033 putative active site [active] 264731006034 putative metal binding site [ion binding]; other site 264731006035 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264731006036 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264731006037 substrate binding site [chemical binding]; other site 264731006038 ATP binding site [chemical binding]; other site 264731006039 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264731006040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731006041 DNA binding residues [nucleotide binding] 264731006042 Anti-sigma-K factor rskA; Region: RskA; pfam10099 264731006043 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731006044 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 264731006045 propionate/acetate kinase; Provisional; Region: PRK12379 264731006046 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 264731006047 Uncharacterized conserved protein [Function unknown]; Region: COG1624 264731006048 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 264731006049 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264731006050 dihydropteroate synthase; Region: DHPS; TIGR01496 264731006051 substrate binding pocket [chemical binding]; other site 264731006052 dimer interface [polypeptide binding]; other site 264731006053 inhibitor binding site; inhibition site 264731006054 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264731006055 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264731006056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731006057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264731006058 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 264731006059 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 264731006060 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264731006061 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264731006062 dimer interface [polypeptide binding]; other site 264731006063 PYR/PP interface [polypeptide binding]; other site 264731006064 TPP binding site [chemical binding]; other site 264731006065 substrate binding site [chemical binding]; other site 264731006066 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 264731006067 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 264731006068 TPP-binding site [chemical binding]; other site 264731006069 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 264731006070 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264731006071 transmembrane helices; other site 264731006072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731006073 active site 264731006074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264731006075 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264731006076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731006077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731006078 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006079 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731006080 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731006081 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731006082 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731006083 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731006084 SusD family; Region: SusD; pfam07980 264731006085 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 264731006086 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 264731006087 active site 264731006088 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 264731006089 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 264731006090 substrate binding [chemical binding]; other site 264731006091 active site 264731006092 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 264731006093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731006094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731006095 putative substrate translocation pore; other site 264731006096 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264731006097 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 264731006098 putative substrate binding site [chemical binding]; other site 264731006099 putative ATP binding site [chemical binding]; other site 264731006100 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 264731006101 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 264731006102 active site 264731006103 substrate-binding site [chemical binding]; other site 264731006104 metal-binding site [ion binding] 264731006105 ATP binding site [chemical binding]; other site 264731006106 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264731006107 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838 264731006108 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 264731006109 catalytic residue [active] 264731006110 putative FPP diphosphate binding site; other site 264731006111 putative FPP binding hydrophobic cleft; other site 264731006112 dimer interface [polypeptide binding]; other site 264731006113 putative IPP diphosphate binding site; other site 264731006114 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264731006115 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264731006116 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264731006117 Surface antigen; Region: Bac_surface_Ag; pfam01103 264731006118 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 264731006119 periplasmic chaperone; Provisional; Region: PRK10780 264731006120 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264731006121 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264731006122 glutamate racemase; Provisional; Region: PRK00865 264731006123 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264731006124 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264731006125 active site 264731006126 Int/Topo IB signature motif; other site 264731006127 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264731006128 Dehydroquinase class II; Region: DHquinase_II; pfam01220 264731006129 active site 264731006130 trimer interface [polypeptide binding]; other site 264731006131 dimer interface [polypeptide binding]; other site 264731006132 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 264731006133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731006134 S-adenosylmethionine binding site [chemical binding]; other site 264731006135 Ribosome-binding factor A; Region: RBFA; pfam02033 264731006136 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264731006137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264731006138 FtsX-like permease family; Region: FtsX; pfam02687 264731006139 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731006140 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264731006141 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731006142 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264731006143 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264731006144 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264731006145 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264731006146 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 264731006147 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 264731006148 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264731006149 active site 264731006150 ribonuclease P; Reviewed; Region: rnpA; PRK01903 264731006151 Haemolytic domain; Region: Haemolytic; pfam01809 264731006152 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264731006153 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264731006154 active site 264731006155 HIGH motif; other site 264731006156 dimer interface [polypeptide binding]; other site 264731006157 KMSKS motif; other site 264731006158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264731006159 RNA binding surface [nucleotide binding]; other site 264731006160 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 264731006161 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 264731006162 NADP binding site [chemical binding]; other site 264731006163 homodimer interface [polypeptide binding]; other site 264731006164 active site 264731006165 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264731006166 IHF - DNA interface [nucleotide binding]; other site 264731006167 IHF dimer interface [polypeptide binding]; other site 264731006168 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 264731006169 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 264731006170 putative catalytic site [active] 264731006171 putative metal binding site [ion binding]; other site 264731006172 putative phosphate binding site [ion binding]; other site 264731006173 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 264731006174 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264731006175 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264731006176 Protein export membrane protein; Region: SecD_SecF; pfam02355 264731006177 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 264731006178 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264731006179 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 264731006180 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 264731006181 active site 264731006182 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731006183 active site 264731006184 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 264731006185 ligand binding site [chemical binding]; other site 264731006186 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 264731006187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731006188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731006189 homodimer interface [polypeptide binding]; other site 264731006190 catalytic residue [active] 264731006191 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 264731006192 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 264731006193 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264731006194 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 264731006195 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731006196 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731006197 beta-D-glucuronidase; Provisional; Region: PRK10150 264731006198 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731006199 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731006200 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731006201 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006202 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731006203 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 264731006204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006206 ATP binding site [chemical binding]; other site 264731006207 Mg2+ binding site [ion binding]; other site 264731006208 G-X-G motif; other site 264731006209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264731006210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731006211 active site 264731006212 phosphorylation site [posttranslational modification] 264731006213 intermolecular recognition site; other site 264731006214 dimerization interface [polypeptide binding]; other site 264731006215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264731006216 DNA binding site [nucleotide binding] 264731006217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 264731006218 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 264731006219 putative acyl-acceptor binding pocket; other site 264731006220 cell division protein MraZ; Reviewed; Region: PRK00326 264731006221 MraZ protein; Region: MraZ; pfam02381 264731006222 MraZ protein; Region: MraZ; pfam02381 264731006223 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264731006224 MraW methylase family; Region: Methyltransf_5; cl17771 264731006225 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264731006226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264731006227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264731006228 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 264731006229 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264731006230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264731006231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731006232 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264731006233 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264731006234 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264731006235 Mg++ binding site [ion binding]; other site 264731006236 putative catalytic motif [active] 264731006237 putative substrate binding site [chemical binding]; other site 264731006238 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 264731006239 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 264731006240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731006241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264731006242 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264731006243 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264731006244 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264731006245 active site 264731006246 homodimer interface [polypeptide binding]; other site 264731006247 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264731006248 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264731006249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264731006250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264731006251 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 264731006252 Cell division protein FtsA; Region: FtsA; smart00842 264731006253 Cell division protein FtsA; Region: FtsA; pfam14450 264731006254 cell division protein FtsZ; Validated; Region: PRK09330 264731006255 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264731006256 nucleotide binding site [chemical binding]; other site 264731006257 SulA interaction site; other site 264731006258 Recombination protein O N terminal; Region: RecO_N; pfam11967 264731006259 Recombination protein O C terminal; Region: RecO_C; pfam02565 264731006260 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264731006261 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 264731006262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006263 ATP binding site [chemical binding]; other site 264731006264 Mg2+ binding site [ion binding]; other site 264731006265 G-X-G motif; other site 264731006266 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264731006267 anchoring element; other site 264731006268 dimer interface [polypeptide binding]; other site 264731006269 ATP binding site [chemical binding]; other site 264731006270 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264731006271 active site 264731006272 putative metal-binding site [ion binding]; other site 264731006273 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264731006274 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731006275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731006276 binding surface 264731006277 TPR motif; other site 264731006278 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731006279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731006280 catalytic residues [active] 264731006281 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006282 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731006283 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731006284 Cache domain; Region: Cache_1; pfam02743 264731006285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731006286 dimerization interface [polypeptide binding]; other site 264731006287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731006289 dimer interface [polypeptide binding]; other site 264731006290 phosphorylation site [posttranslational modification] 264731006291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006292 ATP binding site [chemical binding]; other site 264731006293 Mg2+ binding site [ion binding]; other site 264731006294 G-X-G motif; other site 264731006295 Cache domain; Region: Cache_1; pfam02743 264731006296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731006297 dimerization interface [polypeptide binding]; other site 264731006298 butyrate kinase; Provisional; Region: PRK03011 264731006299 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 264731006300 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731006301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731006302 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 264731006303 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264731006304 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264731006305 ligand binding site [chemical binding]; other site 264731006306 active site 264731006307 UGI interface [polypeptide binding]; other site 264731006308 catalytic site [active] 264731006309 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 264731006310 phosphoglyceromutase; Provisional; Region: PRK05434 264731006311 TfoX N-terminal domain; Region: TfoX_N; pfam04993 264731006312 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 264731006313 heterodimerization interface [polypeptide binding]; other site 264731006314 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731006315 BRO family, N-terminal domain; Region: Bro-N; smart01040 264731006316 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731006317 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 264731006318 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 264731006319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264731006320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731006321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264731006322 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731006323 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731006324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731006325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731006326 putative substrate translocation pore; other site 264731006327 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264731006328 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264731006329 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264731006330 protein binding site [polypeptide binding]; other site 264731006331 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264731006332 Catalytic dyad [active] 264731006333 hypothetical protein; Validated; Region: PRK02001 264731006334 transcription termination factor NusA; Region: NusA; TIGR01953 264731006335 NusA N-terminal domain; Region: NusA_N; pfam08529 264731006336 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264731006337 RNA binding site [nucleotide binding]; other site 264731006338 homodimer interface [polypeptide binding]; other site 264731006339 NusA-like KH domain; Region: KH_5; pfam13184 264731006340 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264731006341 G-X-X-G motif; other site 264731006342 translation initiation factor IF-2; Region: IF-2; TIGR00487 264731006343 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264731006344 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264731006345 G1 box; other site 264731006346 putative GEF interaction site [polypeptide binding]; other site 264731006347 GTP/Mg2+ binding site [chemical binding]; other site 264731006348 Switch I region; other site 264731006349 G2 box; other site 264731006350 G3 box; other site 264731006351 Switch II region; other site 264731006352 G4 box; other site 264731006353 G5 box; other site 264731006354 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264731006355 Translation-initiation factor 2; Region: IF-2; pfam11987 264731006356 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264731006357 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 264731006358 putative ABC transporter; Region: ycf24; CHL00085 264731006359 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264731006360 FeS assembly ATPase SufC; Region: sufC; TIGR01978 264731006361 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 264731006362 Walker A/P-loop; other site 264731006363 ATP binding site [chemical binding]; other site 264731006364 Q-loop/lid; other site 264731006365 ABC transporter signature motif; other site 264731006366 Walker B; other site 264731006367 D-loop; other site 264731006368 H-loop/switch region; other site 264731006369 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 264731006370 FeS assembly protein SufD; Region: sufD; TIGR01981 264731006371 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 264731006372 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264731006373 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264731006374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264731006375 catalytic residue [active] 264731006376 alpha-galactosidase; Region: PLN02808; cl17638 264731006377 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 264731006378 Ca binding site [ion binding]; other site 264731006379 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264731006380 RNA/DNA hybrid binding site [nucleotide binding]; other site 264731006381 active site 264731006382 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 264731006383 EamA-like transporter family; Region: EamA; pfam00892 264731006384 EamA-like transporter family; Region: EamA; pfam00892 264731006385 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 264731006386 radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133 264731006387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731006388 FeS/SAM binding site; other site 264731006389 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264731006390 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 264731006391 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 264731006392 putative active site [active] 264731006393 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 264731006394 active site 264731006395 catalytic residues [active] 264731006396 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264731006397 active site 264731006398 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264731006399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731006400 motif II; other site 264731006401 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 264731006402 metal binding site 2 [ion binding]; metal-binding site 264731006403 putative DNA binding helix; other site 264731006404 metal binding site 1 [ion binding]; metal-binding site 264731006405 dimer interface [polypeptide binding]; other site 264731006406 structural Zn2+ binding site [ion binding]; other site 264731006407 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264731006408 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264731006409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731006410 Walker A motif; other site 264731006411 ATP binding site [chemical binding]; other site 264731006412 Walker B motif; other site 264731006413 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264731006414 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731006415 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731006416 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731006417 catalytic residues [active] 264731006418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731006419 TPR motif; other site 264731006420 binding surface 264731006421 argininosuccinate lyase; Provisional; Region: PRK00855 264731006422 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264731006423 active sites [active] 264731006424 tetramer interface [polypeptide binding]; other site 264731006425 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264731006426 hydrophobic ligand binding site; other site 264731006427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731006428 active site 264731006429 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264731006430 RecX family; Region: RecX; pfam02631 264731006431 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264731006432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264731006433 S-adenosylmethionine binding site [chemical binding]; other site 264731006434 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 264731006435 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264731006436 catalytic motif [active] 264731006437 Zn binding site [ion binding]; other site 264731006438 RibD C-terminal domain; Region: RibD_C; cl17279 264731006439 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 264731006440 putative active site [active] 264731006441 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 264731006442 RNA/DNA hybrid binding site [nucleotide binding]; other site 264731006443 active site 264731006444 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 264731006445 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 264731006446 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731006447 active site 264731006448 HIGH motif; other site 264731006449 nucleotide binding site [chemical binding]; other site 264731006450 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264731006451 KMSK motif region; other site 264731006452 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 264731006453 tRNA binding surface [nucleotide binding]; other site 264731006454 anticodon binding site; other site 264731006455 NMT1/THI5 like; Region: NMT1; pfam09084 264731006456 Cache domain; Region: Cache_1; pfam02743 264731006457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731006458 binding surface 264731006459 TPR motif; other site 264731006460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731006462 dimer interface [polypeptide binding]; other site 264731006463 phosphorylation site [posttranslational modification] 264731006464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006465 ATP binding site [chemical binding]; other site 264731006466 Mg2+ binding site [ion binding]; other site 264731006467 G-X-G motif; other site 264731006468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264731006469 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264731006470 active site 264731006471 motif I; other site 264731006472 motif II; other site 264731006473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 264731006474 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264731006475 EamA-like transporter family; Region: EamA; pfam00892 264731006476 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264731006477 amino acid carrier protein; Region: agcS; TIGR00835 264731006478 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264731006479 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264731006480 transmembrane helices; other site 264731006481 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264731006482 TrkA-C domain; Region: TrkA_C; pfam02080 264731006483 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264731006484 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264731006485 EamA-like transporter family; Region: EamA; pfam00892 264731006486 EamA-like transporter family; Region: EamA; pfam00892 264731006487 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264731006488 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264731006489 catalytic triad [active] 264731006490 AAA domain; Region: AAA_14; pfam13173 264731006491 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 264731006492 Archaeal ATPase; Region: Arch_ATPase; pfam01637 264731006493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264731006494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731006495 active site 264731006496 phosphorylation site [posttranslational modification] 264731006497 intermolecular recognition site; other site 264731006498 dimerization interface [polypeptide binding]; other site 264731006499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264731006500 DNA binding site [nucleotide binding] 264731006501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731006503 dimer interface [polypeptide binding]; other site 264731006504 phosphorylation site [posttranslational modification] 264731006505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006506 ATP binding site [chemical binding]; other site 264731006507 Mg2+ binding site [ion binding]; other site 264731006508 G-X-G motif; other site 264731006509 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731006510 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006511 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731006512 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731006513 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 264731006514 HicB family; Region: HicB; pfam05534 264731006515 HipA N-terminal domain; Region: Couple_hipA; pfam13657 264731006516 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 264731006517 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264731006518 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264731006519 Protein of unknown function DUF262; Region: DUF262; pfam03235 264731006520 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 264731006521 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 264731006522 active site 264731006523 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 264731006524 Virulence-associated protein E; Region: VirE; pfam05272 264731006525 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 264731006526 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731006527 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264731006528 amidase catalytic site [active] 264731006529 Zn binding residues [ion binding]; other site 264731006530 substrate binding site [chemical binding]; other site 264731006531 Cupin domain; Region: Cupin_2; pfam07883 264731006532 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 264731006533 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264731006534 active site 264731006535 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 264731006536 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264731006537 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264731006538 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 264731006539 L-aspartate oxidase; Provisional; Region: PRK06175 264731006540 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264731006541 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 264731006542 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 264731006543 putative Iron-sulfur protein interface [polypeptide binding]; other site 264731006544 proximal heme binding site [chemical binding]; other site 264731006545 distal heme binding site [chemical binding]; other site 264731006546 putative dimer interface [polypeptide binding]; other site 264731006547 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731006548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731006549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731006550 DNA binding residues [nucleotide binding] 264731006551 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731006552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731006553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731006554 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731006555 active site 264731006556 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 264731006557 active site 264731006558 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731006559 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006560 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731006561 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006562 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731006563 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731006564 SusD family; Region: SusD; pfam07980 264731006565 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 264731006566 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 264731006567 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 264731006568 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731006569 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731006570 SusD family; Region: SusD; pfam07980 264731006571 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731006572 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006573 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731006574 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731006575 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731006576 Two component regulator propeller; Region: Reg_prop; pfam07494 264731006577 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731006578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731006580 dimer interface [polypeptide binding]; other site 264731006581 phosphorylation site [posttranslational modification] 264731006582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006583 ATP binding site [chemical binding]; other site 264731006584 Mg2+ binding site [ion binding]; other site 264731006585 G-X-G motif; other site 264731006586 Response regulator receiver domain; Region: Response_reg; pfam00072 264731006587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731006588 active site 264731006589 phosphorylation site [posttranslational modification] 264731006590 intermolecular recognition site; other site 264731006591 dimerization interface [polypeptide binding]; other site 264731006592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731006593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731006594 WbqC-like protein family; Region: WbqC; pfam08889 264731006595 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 264731006596 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264731006597 Catalytic site [active] 264731006598 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264731006599 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264731006600 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264731006601 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264731006602 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264731006603 oligomerization interface [polypeptide binding]; other site 264731006604 active site 264731006605 metal binding site [ion binding]; metal-binding site 264731006606 pantoate--beta-alanine ligase; Region: panC; TIGR00018 264731006607 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264731006608 active site 264731006609 ATP-binding site [chemical binding]; other site 264731006610 pantoate-binding site; other site 264731006611 HXXH motif; other site 264731006612 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 264731006613 tetramerization interface [polypeptide binding]; other site 264731006614 active site 264731006615 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 264731006616 Flavoprotein; Region: Flavoprotein; pfam02441 264731006617 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 264731006618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264731006619 nucleotide binding site [chemical binding]; other site 264731006620 Type III pantothenate kinase; Region: Pan_kinase; cl17198 264731006621 Penicillinase repressor; Region: Pencillinase_R; pfam03965 264731006622 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 264731006623 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 264731006624 Abi-like protein; Region: Abi_2; pfam07751 264731006625 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264731006626 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006627 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006628 Chloramphenicol acetyltransferase; Region: CAT; cl02008 264731006629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731006630 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731006631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731006632 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 264731006633 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 264731006634 DNA protecting protein DprA; Region: dprA; TIGR00732 264731006635 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 264731006636 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 264731006637 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264731006638 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264731006639 FMN binding site [chemical binding]; other site 264731006640 active site 264731006641 catalytic residues [active] 264731006642 substrate binding site [chemical binding]; other site 264731006643 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 264731006644 active site 264731006645 catalytic triad [active] 264731006646 oxyanion hole [active] 264731006647 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 264731006648 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264731006649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264731006650 Walker A motif; other site 264731006651 ATP binding site [chemical binding]; other site 264731006652 Walker B motif; other site 264731006653 arginine finger; other site 264731006654 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264731006655 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264731006656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731006657 active site 264731006658 nucleotide binding site [chemical binding]; other site 264731006659 HIGH motif; other site 264731006660 KMSKS motif; other site 264731006661 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 264731006662 FMN-binding domain; Region: FMN_bind; pfam04205 264731006663 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 264731006664 trimer interface [polypeptide binding]; other site 264731006665 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264731006666 substrate binding site [chemical binding]; other site 264731006667 Mn binding site [ion binding]; other site 264731006668 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264731006669 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 264731006670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006671 ATP binding site [chemical binding]; other site 264731006672 Mg2+ binding site [ion binding]; other site 264731006673 G-X-G motif; other site 264731006674 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 264731006675 ATP binding site [chemical binding]; other site 264731006676 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 264731006677 active site 264731006678 putative metal-binding site [ion binding]; other site 264731006679 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264731006680 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264731006681 C-terminal peptidase (prc); Region: prc; TIGR00225 264731006682 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264731006683 protein binding site [polypeptide binding]; other site 264731006684 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264731006685 Catalytic dyad [active] 264731006686 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264731006687 active site residue [active] 264731006688 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264731006689 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 264731006690 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264731006691 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731006692 active site 264731006693 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264731006694 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264731006695 GIY-YIG motif/motif A; other site 264731006696 active site 264731006697 catalytic site [active] 264731006698 putative DNA binding site [nucleotide binding]; other site 264731006699 metal binding site [ion binding]; metal-binding site 264731006700 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264731006701 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264731006702 putative active site [active] 264731006703 dimerization interface [polypeptide binding]; other site 264731006704 putative tRNAtyr binding site [nucleotide binding]; other site 264731006705 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 264731006706 homodimer interface [polypeptide binding]; other site 264731006707 metal binding site [ion binding]; metal-binding site 264731006708 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 264731006709 intersubunit interface [polypeptide binding]; other site 264731006710 active site 264731006711 catalytic residue [active] 264731006712 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264731006713 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264731006714 substrate binding pocket [chemical binding]; other site 264731006715 chain length determination region; other site 264731006716 substrate-Mg2+ binding site; other site 264731006717 catalytic residues [active] 264731006718 aspartate-rich region 1; other site 264731006719 active site lid residues [active] 264731006720 aspartate-rich region 2; other site 264731006721 DNA polymerase I; Provisional; Region: PRK05755 264731006722 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264731006723 active site 264731006724 metal binding site 1 [ion binding]; metal-binding site 264731006725 putative 5' ssDNA interaction site; other site 264731006726 metal binding site 3; metal-binding site 264731006727 metal binding site 2 [ion binding]; metal-binding site 264731006728 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264731006729 putative DNA binding site [nucleotide binding]; other site 264731006730 putative metal binding site [ion binding]; other site 264731006731 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 264731006732 active site 264731006733 catalytic site [active] 264731006734 substrate binding site [chemical binding]; other site 264731006735 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264731006736 active site 264731006737 DNA binding site [nucleotide binding] 264731006738 catalytic site [active] 264731006739 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 264731006740 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 264731006741 active site 264731006742 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264731006743 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264731006744 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264731006745 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264731006746 PhoU domain; Region: PhoU; pfam01895 264731006747 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731006748 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006749 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 264731006750 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 264731006751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731006752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264731006753 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 264731006754 acyl-activating enzyme (AAE) consensus motif; other site 264731006755 acyl-activating enzyme (AAE) consensus motif; other site 264731006756 putative AMP binding site [chemical binding]; other site 264731006757 putative active site [active] 264731006758 putative CoA binding site [chemical binding]; other site 264731006759 peptide chain release factor 2; Validated; Region: prfB; PRK00578 264731006760 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264731006761 RF-1 domain; Region: RF-1; pfam00472 264731006762 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 264731006763 putative active site [active] 264731006764 putative metal binding residues [ion binding]; other site 264731006765 signature motif; other site 264731006766 putative dimer interface [polypeptide binding]; other site 264731006767 putative phosphate binding site [ion binding]; other site 264731006768 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 264731006769 Na2 binding site [ion binding]; other site 264731006770 putative substrate binding site 1 [chemical binding]; other site 264731006771 Na binding site 1 [ion binding]; other site 264731006772 putative substrate binding site 2 [chemical binding]; other site 264731006773 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 264731006774 Na2 binding site [ion binding]; other site 264731006775 putative substrate binding site 1 [chemical binding]; other site 264731006776 Na binding site 1 [ion binding]; other site 264731006777 putative substrate binding site 2 [chemical binding]; other site 264731006778 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264731006779 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264731006780 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264731006781 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 264731006782 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 264731006783 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 264731006784 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264731006785 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264731006786 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264731006787 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731006788 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 264731006789 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264731006790 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264731006791 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 264731006792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264731006793 active site 264731006794 catalytic tetrad [active] 264731006795 GTP-binding protein YchF; Reviewed; Region: PRK09601 264731006796 YchF GTPase; Region: YchF; cd01900 264731006797 G1 box; other site 264731006798 GTP/Mg2+ binding site [chemical binding]; other site 264731006799 Switch I region; other site 264731006800 G2 box; other site 264731006801 Switch II region; other site 264731006802 G3 box; other site 264731006803 G4 box; other site 264731006804 G5 box; other site 264731006805 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264731006806 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264731006807 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264731006808 MutS domain I; Region: MutS_I; pfam01624 264731006809 MutS domain II; Region: MutS_II; pfam05188 264731006810 MutS domain III; Region: MutS_III; pfam05192 264731006811 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 264731006812 Walker A/P-loop; other site 264731006813 ATP binding site [chemical binding]; other site 264731006814 Q-loop/lid; other site 264731006815 ABC transporter signature motif; other site 264731006816 Walker B; other site 264731006817 D-loop; other site 264731006818 H-loop/switch region; other site 264731006819 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264731006820 dimer interface [polypeptide binding]; other site 264731006821 catalytic triad [active] 264731006822 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006823 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 264731006824 Uncharacterized conserved protein [Function unknown]; Region: COG3391 264731006825 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264731006826 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264731006827 intersubunit interface [polypeptide binding]; other site 264731006828 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 264731006829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731006830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731006831 homodimer interface [polypeptide binding]; other site 264731006832 catalytic residue [active] 264731006833 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 264731006834 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264731006835 Walker A/P-loop; other site 264731006836 ATP binding site [chemical binding]; other site 264731006837 Q-loop/lid; other site 264731006838 ABC transporter signature motif; other site 264731006839 Walker B; other site 264731006840 D-loop; other site 264731006841 H-loop/switch region; other site 264731006842 Predicted membrane protein [Function unknown]; Region: COG1971 264731006843 Domain of unknown function DUF; Region: DUF204; pfam02659 264731006844 Domain of unknown function DUF; Region: DUF204; pfam02659 264731006845 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 264731006846 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 264731006847 Melibiase; Region: Melibiase; pfam02065 264731006848 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731006849 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731006850 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731006851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731006852 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 264731006853 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731006854 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731006855 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731006856 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731006857 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 264731006858 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731006859 Fic family protein [Function unknown]; Region: COG3177 264731006860 Fic/DOC family; Region: Fic; pfam02661 264731006861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264731006862 active site 264731006863 substrate binding site [chemical binding]; other site 264731006864 ATP binding site [chemical binding]; other site 264731006865 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264731006866 activation loop (A-loop); other site 264731006867 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731006868 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731006869 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 264731006870 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 264731006871 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 264731006872 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264731006873 substrate binding site [chemical binding]; other site 264731006874 trimer interface [polypeptide binding]; other site 264731006875 Mn binding site [ion binding]; other site 264731006876 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 264731006877 aminoacyl-tRNA ligase; Region: PLN02563 264731006878 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731006879 active site 264731006880 HIGH motif; other site 264731006881 nucleotide binding site [chemical binding]; other site 264731006882 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264731006883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731006884 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264731006885 active site 264731006886 KMSKS motif; other site 264731006887 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264731006888 tRNA binding surface [nucleotide binding]; other site 264731006889 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264731006890 active site 264731006891 dimerization interface [polypeptide binding]; other site 264731006892 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 264731006893 quinolinate synthetase; Provisional; Region: PRK09375 264731006894 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264731006895 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731006896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731006897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731006898 DNA binding residues [nucleotide binding] 264731006899 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264731006900 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264731006901 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264731006902 active site 264731006903 HIGH motif; other site 264731006904 KMSKS motif; other site 264731006905 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264731006906 tRNA binding surface [nucleotide binding]; other site 264731006907 anticodon binding site; other site 264731006908 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264731006909 dimer interface [polypeptide binding]; other site 264731006910 putative tRNA-binding site [nucleotide binding]; other site 264731006911 colanic acid exporter; Provisional; Region: PRK10459 264731006912 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 264731006913 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264731006914 substrate binding site; other site 264731006915 dimer interface; other site 264731006916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731006917 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731006918 NAD(P) binding site [chemical binding]; other site 264731006919 active site 264731006920 LicD family; Region: LicD; pfam04991 264731006921 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264731006922 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264731006923 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264731006924 Sulfatase; Region: Sulfatase; cl17466 264731006925 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264731006926 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264731006927 active site 264731006928 (T/H)XGH motif; other site 264731006929 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264731006930 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264731006931 catalytic site [active] 264731006932 G-X2-G-X-G-K; other site 264731006933 hypothetical protein; Provisional; Region: PRK11820 264731006934 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264731006935 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264731006936 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731006937 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264731006938 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264731006939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264731006940 N-terminal plug; other site 264731006941 ligand-binding site [chemical binding]; other site 264731006942 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264731006943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731006944 putative substrate translocation pore; other site 264731006945 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 264731006946 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264731006947 active site 264731006948 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 264731006949 Bacterial Ig-like domain; Region: Big_5; pfam13205 264731006950 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 264731006951 GH3 auxin-responsive promoter; Region: GH3; pfam03321 264731006952 Anti-sigma-K factor rskA; Region: RskA; pfam10099 264731006953 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264731006954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731006955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731006956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731006957 DNA binding residues [nucleotide binding] 264731006958 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 264731006959 serpin-like protein; Provisional; Region: PHA02660 264731006960 reactive center loop; other site 264731006961 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 264731006962 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264731006963 dimerization interface [polypeptide binding]; other site 264731006964 active site 264731006965 metal binding site [ion binding]; metal-binding site 264731006966 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264731006967 dsRNA binding site [nucleotide binding]; other site 264731006968 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 264731006969 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264731006970 dimer interface [polypeptide binding]; other site 264731006971 active site 264731006972 acyl carrier protein; Provisional; Region: acpP; PRK00982 264731006973 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 264731006974 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264731006975 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264731006976 putative active site [active] 264731006977 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264731006978 Rubredoxin; Region: Rubredoxin; pfam00301 264731006979 iron binding site [ion binding]; other site 264731006980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731006981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731006982 substrate binding pocket [chemical binding]; other site 264731006983 membrane-bound complex binding site; other site 264731006984 hinge residues; other site 264731006985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731006987 dimer interface [polypeptide binding]; other site 264731006988 phosphorylation site [posttranslational modification] 264731006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731006990 ATP binding site [chemical binding]; other site 264731006991 Mg2+ binding site [ion binding]; other site 264731006992 G-X-G motif; other site 264731006993 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264731006994 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 264731006995 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264731006996 ABC-ATPase subunit interface; other site 264731006997 dimer interface [polypeptide binding]; other site 264731006998 putative PBP binding regions; other site 264731006999 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007000 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007001 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731007002 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007003 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007004 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 264731007005 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 264731007006 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 264731007007 active site 264731007008 Zn binding site [ion binding]; other site 264731007009 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731007011 LytTr DNA-binding domain; Region: LytTR; smart00850 264731007012 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264731007013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264731007014 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264731007015 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264731007016 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264731007017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731007018 Coenzyme A binding pocket [chemical binding]; other site 264731007019 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 264731007020 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264731007021 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264731007022 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 264731007023 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264731007024 conserved cys residue [active] 264731007025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264731007026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264731007027 active site 264731007028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264731007029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264731007030 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264731007031 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264731007032 Putative esterase; Region: Esterase; pfam00756 264731007033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 264731007034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264731007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731007036 Coenzyme A binding pocket [chemical binding]; other site 264731007037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264731007038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264731007039 Coenzyme A binding pocket [chemical binding]; other site 264731007040 Predicted membrane protein [Function unknown]; Region: COG2311 264731007041 Protein of unknown function (DUF418); Region: DUF418; cl12135 264731007042 Protein of unknown function (DUF418); Region: DUF418; pfam04235 264731007043 LytTr DNA-binding domain; Region: LytTR; pfam04397 264731007044 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731007046 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731007047 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264731007048 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 264731007049 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731007050 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731007051 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731007052 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731007053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731007054 binding surface 264731007055 TPR motif; other site 264731007056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731007057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731007058 dimer interface [polypeptide binding]; other site 264731007059 phosphorylation site [posttranslational modification] 264731007060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731007061 ATP binding site [chemical binding]; other site 264731007062 Mg2+ binding site [ion binding]; other site 264731007063 G-X-G motif; other site 264731007064 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731007065 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731007066 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264731007067 Ligand Binding Site [chemical binding]; other site 264731007068 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264731007069 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264731007070 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264731007071 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 264731007072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731007073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731007074 DNA binding residues [nucleotide binding] 264731007075 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 264731007076 substrate binding site [chemical binding]; other site 264731007077 active site 264731007078 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 264731007079 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 264731007080 Domain of unknown function (DUF303); Region: DUF303; pfam03629 264731007081 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 264731007082 Domain of unknown function (DUF303); Region: DUF303; pfam03629 264731007083 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 264731007084 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731007085 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731007086 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 264731007087 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 264731007088 active site 264731007089 Virulence-associated protein E; Region: VirE; pfam05272 264731007090 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 264731007091 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 264731007092 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 264731007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 264731007094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264731007095 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 264731007096 substrate binding site [chemical binding]; other site 264731007097 ATP binding site [chemical binding]; other site 264731007098 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264731007099 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 264731007100 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007101 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007103 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731007104 SusD family; Region: SusD; pfam07980 264731007105 NMT1/THI5 like; Region: NMT1; pfam09084 264731007106 Cache domain; Region: Cache_1; pfam02743 264731007107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731007108 dimerization interface [polypeptide binding]; other site 264731007109 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731007110 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731007111 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731007112 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 264731007113 putative active site pocket [active] 264731007114 cleavage site 264731007115 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264731007116 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264731007117 active site 264731007118 Riboflavin kinase; Region: Flavokinase; pfam01687 264731007119 CAAX protease self-immunity; Region: Abi; pfam02517 264731007120 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264731007121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264731007122 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264731007123 DNA binding residues [nucleotide binding] 264731007124 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 264731007125 nucleotide binding site [chemical binding]; other site 264731007126 N-acetyl-L-glutamate binding site [chemical binding]; other site 264731007127 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264731007128 synthetase active site [active] 264731007129 NTP binding site [chemical binding]; other site 264731007130 metal binding site [ion binding]; metal-binding site 264731007131 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264731007132 anti sigma factor interaction site; other site 264731007133 regulatory phosphorylation site [posttranslational modification]; other site 264731007134 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 264731007135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264731007136 ATP binding site [chemical binding]; other site 264731007137 Mg2+ binding site [ion binding]; other site 264731007138 G-X-G motif; other site 264731007139 arginine decarboxylase; Provisional; Region: PRK05354 264731007140 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 264731007141 dimer interface [polypeptide binding]; other site 264731007142 active site 264731007143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264731007144 catalytic residues [active] 264731007145 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 264731007146 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 264731007147 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264731007148 Shikimate kinase; Region: SKI; pfam01202 264731007149 ADP binding site [chemical binding]; other site 264731007150 magnesium binding site [ion binding]; other site 264731007151 putative shikimate binding site; other site 264731007152 DNA topoisomerase I; Provisional; Region: PRK08780 264731007153 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264731007154 active site 264731007155 interdomain interaction site; other site 264731007156 putative metal-binding site [ion binding]; other site 264731007157 nucleotide binding site [chemical binding]; other site 264731007158 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264731007159 domain I; other site 264731007160 DNA binding groove [nucleotide binding] 264731007161 phosphate binding site [ion binding]; other site 264731007162 domain II; other site 264731007163 domain III; other site 264731007164 nucleotide binding site [chemical binding]; other site 264731007165 catalytic site [active] 264731007166 domain IV; other site 264731007167 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264731007168 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264731007169 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264731007170 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681 264731007171 nudix motif; other site 264731007172 Domain of unknown function (DUF303); Region: DUF303; pfam03629 264731007173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264731007174 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731007175 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731007176 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731007177 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731007178 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264731007179 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264731007180 RNase E interface [polypeptide binding]; other site 264731007181 trimer interface [polypeptide binding]; other site 264731007182 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264731007183 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264731007184 RNase E interface [polypeptide binding]; other site 264731007185 trimer interface [polypeptide binding]; other site 264731007186 active site 264731007187 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264731007188 putative nucleic acid binding region [nucleotide binding]; other site 264731007189 G-X-X-G motif; other site 264731007190 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264731007191 RNA binding site [nucleotide binding]; other site 264731007192 domain interface; other site 264731007193 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264731007194 23S rRNA interface [nucleotide binding]; other site 264731007195 L3 interface [polypeptide binding]; other site 264731007196 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264731007197 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264731007198 rRNA interaction site [nucleotide binding]; other site 264731007199 S8 interaction site; other site 264731007200 putative laminin-1 binding site; other site 264731007201 elongation factor Ts; Provisional; Region: tsf; PRK09377 264731007202 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 264731007203 Elongation factor TS; Region: EF_TS; pfam00889 264731007204 Elongation factor TS; Region: EF_TS; pfam00889 264731007205 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 264731007206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264731007207 putative substrate binding site [chemical binding]; other site 264731007208 putative ATP binding site [chemical binding]; other site 264731007209 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264731007210 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264731007211 ATP binding site [chemical binding]; other site 264731007212 Mg++ binding site [ion binding]; other site 264731007213 motif III; other site 264731007214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264731007215 nucleotide binding region [chemical binding]; other site 264731007216 ATP-binding site [chemical binding]; other site 264731007217 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 264731007218 RNA binding site [nucleotide binding]; other site 264731007219 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264731007220 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264731007221 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731007222 Peptidase S46; Region: Peptidase_S46; pfam10459 264731007223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264731007224 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264731007225 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264731007226 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264731007227 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 264731007228 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 264731007229 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264731007230 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731007231 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 264731007232 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731007233 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 264731007234 Putative esterase; Region: Esterase; pfam00756 264731007235 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264731007236 MgtC family; Region: MgtC; pfam02308 264731007237 AAA domain; Region: AAA_11; pfam13086 264731007238 Part of AAA domain; Region: AAA_19; pfam13245 264731007239 AAA domain; Region: AAA_30; pfam13604 264731007240 AAA domain; Region: AAA_12; pfam13087 264731007241 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 264731007242 substrate binding site [chemical binding]; other site 264731007243 ATP binding site [chemical binding]; other site 264731007244 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264731007245 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264731007246 active site 264731007247 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264731007248 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 264731007249 Zn binding site [ion binding]; other site 264731007250 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 264731007251 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264731007252 dimerization interface [polypeptide binding]; other site 264731007253 ATP binding site [chemical binding]; other site 264731007254 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264731007255 dimerization interface [polypeptide binding]; other site 264731007256 ATP binding site [chemical binding]; other site 264731007257 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264731007258 putative active site [active] 264731007259 catalytic triad [active] 264731007260 Chromate transporter; Region: Chromate_transp; pfam02417 264731007261 Chromate transporter; Region: Chromate_transp; pfam02417 264731007262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264731007263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264731007264 DNA binding site [nucleotide binding] 264731007265 domain linker motif; other site 264731007266 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264731007267 dimerization interface [polypeptide binding]; other site 264731007268 ligand binding site [chemical binding]; other site 264731007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731007270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264731007271 putative substrate translocation pore; other site 264731007272 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731007273 Two component regulator propeller; Region: Reg_prop; pfam07494 264731007274 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731007275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731007276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007277 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007278 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007279 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731007280 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007281 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731007282 SusD family; Region: SusD; pfam07980 264731007283 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 264731007284 substrate binding site [chemical binding]; other site 264731007285 active site 264731007286 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 264731007287 substrate binding site [chemical binding]; other site 264731007288 active site 264731007289 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 264731007290 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 264731007291 active site 264731007292 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 264731007293 BNR repeat-like domain; Region: BNR_2; pfam13088 264731007294 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 264731007295 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731007296 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264731007297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731007298 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 264731007299 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 264731007300 active site 264731007301 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007302 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007303 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731007304 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007305 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731007306 SusE outer membrane protein; Region: SusE; pfam14292 264731007307 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 264731007308 starch binding site [chemical binding]; other site 264731007309 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 264731007310 starch binding site [chemical binding]; other site 264731007311 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 264731007312 starch binding site [chemical binding]; other site 264731007313 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 264731007314 starch binding site [chemical binding]; other site 264731007315 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 264731007316 starch binding site [chemical binding]; other site 264731007317 alpha-amylase; Region: PLN02361 264731007318 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 264731007319 active site 264731007320 Ca binding site [ion binding]; other site 264731007321 catalytic site [active] 264731007322 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 264731007323 metal-binding site 264731007324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264731007325 active site 264731007326 substrate binding site [chemical binding]; other site 264731007327 trimer interface [polypeptide binding]; other site 264731007328 CoA binding site [chemical binding]; other site 264731007329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731007330 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 264731007331 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264731007332 homotrimer interaction site [polypeptide binding]; other site 264731007333 zinc binding site [ion binding]; other site 264731007334 CDP-binding sites; other site 264731007335 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 264731007336 active site 264731007337 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 264731007338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264731007339 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264731007340 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264731007341 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731007342 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 264731007343 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731007344 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 264731007345 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264731007346 Putative esterase; Region: Esterase; pfam00756 264731007347 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731007348 SusD family; Region: SusD; pfam07980 264731007349 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007350 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007351 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731007352 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 264731007353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007354 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731007355 Two component regulator propeller; Region: Reg_prop; pfam07494 264731007356 Two component regulator propeller; Region: Reg_prop; pfam07494 264731007357 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731007358 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731007359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731007360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731007361 dimer interface [polypeptide binding]; other site 264731007362 phosphorylation site [posttranslational modification] 264731007363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731007364 ATP binding site [chemical binding]; other site 264731007365 Mg2+ binding site [ion binding]; other site 264731007366 G-X-G motif; other site 264731007367 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264731007368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731007369 active site 264731007370 phosphorylation site [posttranslational modification] 264731007371 intermolecular recognition site; other site 264731007372 dimerization interface [polypeptide binding]; other site 264731007373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731007374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007375 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 264731007376 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 264731007377 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 264731007378 Ca binding site [ion binding]; other site 264731007379 active site 264731007380 homodimer interface [polypeptide binding]; other site 264731007381 catalytic site [active] 264731007382 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 264731007383 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264731007384 active site 264731007385 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 264731007386 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 264731007387 substrate binding site [chemical binding]; other site 264731007388 active site 264731007389 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 264731007390 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731007391 SusD family; Region: SusD; pfam07980 264731007392 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007393 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007394 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731007395 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731007396 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007397 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007398 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731007399 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 264731007400 Domain of unknown function (DUF303); Region: DUF303; pfam03629 264731007401 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 264731007402 Predicted esterase [General function prediction only]; Region: COG0627 264731007403 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264731007404 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007405 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007406 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731007407 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007408 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731007409 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731007410 Uncharacterized conserved protein [Function unknown]; Region: COG3538 264731007411 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 264731007412 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 264731007413 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 264731007414 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007415 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007416 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731007417 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007418 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731007419 SusD family; Region: SusD; pfam07980 264731007420 SusE outer membrane protein; Region: SusE; pfam14292 264731007421 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 264731007422 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731007423 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 264731007424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731007425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731007426 dimer interface [polypeptide binding]; other site 264731007427 phosphorylation site [posttranslational modification] 264731007428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731007429 ATP binding site [chemical binding]; other site 264731007430 Mg2+ binding site [ion binding]; other site 264731007431 G-X-G motif; other site 264731007432 Response regulator receiver domain; Region: Response_reg; pfam00072 264731007433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731007434 active site 264731007435 phosphorylation site [posttranslational modification] 264731007436 intermolecular recognition site; other site 264731007437 dimerization interface [polypeptide binding]; other site 264731007438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731007439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007440 Archaeal ATPase; Region: Arch_ATPase; pfam01637 264731007441 MarR family; Region: MarR_2; pfam12802 264731007442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007443 binding surface 264731007444 TPR motif; other site 264731007445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007446 TPR motif; other site 264731007447 binding surface 264731007448 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731007449 GLPGLI family protein; Region: GLPGLI; TIGR01200 264731007450 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007451 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 264731007452 Penicillinase repressor; Region: Pencillinase_R; pfam03965 264731007453 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 264731007454 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 264731007455 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007456 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 264731007457 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731007458 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731007459 catalytic residues [active] 264731007460 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264731007461 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 264731007462 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 264731007463 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264731007464 Protein of unknown function, DUF608; Region: DUF608; pfam04685 264731007465 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264731007466 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731007467 PA14 domain; Region: PA14; cl08459 264731007468 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731007469 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264731007470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264731007471 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 264731007472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731007473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731007474 dimer interface [polypeptide binding]; other site 264731007475 phosphorylation site [posttranslational modification] 264731007476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731007477 ATP binding site [chemical binding]; other site 264731007478 Mg2+ binding site [ion binding]; other site 264731007479 G-X-G motif; other site 264731007480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264731007481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731007482 active site 264731007483 phosphorylation site [posttranslational modification] 264731007484 intermolecular recognition site; other site 264731007485 dimerization interface [polypeptide binding]; other site 264731007486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731007488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007489 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 264731007490 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007491 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007492 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731007493 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007494 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731007495 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731007496 SusD family; Region: SusD; pfam07980 264731007497 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007498 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 264731007499 starch binding outer membrane protein SusD; Region: SusD; cl17845 264731007500 SusD family; Region: SusD; pfam07980 264731007501 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 264731007502 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 264731007503 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 264731007504 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 264731007505 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264731007506 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 264731007507 substrate binding site [chemical binding]; other site 264731007508 active site 264731007509 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 264731007510 metal binding site [ion binding]; metal-binding site 264731007511 ligand binding site [chemical binding]; other site 264731007512 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 264731007513 substrate binding site [chemical binding]; other site 264731007514 active site 264731007515 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 264731007516 metal binding site [ion binding]; metal-binding site 264731007517 ligand binding site [chemical binding]; other site 264731007518 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 264731007519 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 264731007520 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 264731007521 active site 264731007522 catalytic site [active] 264731007523 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 264731007524 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 264731007525 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264731007526 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 264731007527 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264731007528 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264731007529 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 264731007530 pullulanase, type I; Region: pulA_typeI; TIGR02104 264731007531 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 264731007532 Ca binding site [ion binding]; other site 264731007533 active site 264731007534 catalytic site [active] 264731007535 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 264731007536 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731007537 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 264731007538 starch-binding site 2 [chemical binding]; other site 264731007539 starch-binding site 1 [chemical binding]; other site 264731007540 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 264731007541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264731007542 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264731007543 substrate binding pocket [chemical binding]; other site 264731007544 membrane-bound complex binding site; other site 264731007545 hinge residues; other site 264731007546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731007547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731007548 dimer interface [polypeptide binding]; other site 264731007549 phosphorylation site [posttranslational modification] 264731007550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731007551 ATP binding site [chemical binding]; other site 264731007552 Mg2+ binding site [ion binding]; other site 264731007553 G-X-G motif; other site 264731007554 ribonuclease R; Region: RNase_R; TIGR02063 264731007555 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264731007556 RNB domain; Region: RNB; pfam00773 264731007557 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264731007558 RNA binding site [nucleotide binding]; other site 264731007559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264731007560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264731007561 NAD(P) binding site [chemical binding]; other site 264731007562 active site 264731007563 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 264731007564 active site 264731007565 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264731007566 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264731007567 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264731007568 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264731007569 nucleotide binding site/active site [active] 264731007570 HIT family signature motif; other site 264731007571 catalytic residue [active] 264731007572 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 264731007573 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264731007574 Substrate binding site; other site 264731007575 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 264731007576 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264731007577 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 264731007578 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264731007579 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 264731007580 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 264731007581 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 264731007582 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731007583 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731007584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264731007585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264731007586 DNA binding site [nucleotide binding] 264731007587 domain linker motif; other site 264731007588 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264731007589 dimerization interface [polypeptide binding]; other site 264731007590 ligand binding site [chemical binding]; other site 264731007591 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007592 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 264731007593 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731007594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007595 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 264731007596 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 264731007597 active site 264731007598 multimer interface [polypeptide binding]; other site 264731007599 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 264731007600 predicted active site [active] 264731007601 catalytic triad [active] 264731007602 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264731007603 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264731007604 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 264731007605 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 264731007606 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 264731007607 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731007608 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 264731007609 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 264731007610 active site 264731007611 metal binding site [ion binding]; metal-binding site 264731007612 interdomain interaction site; other site 264731007613 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264731007614 Walker A motif; other site 264731007615 ATP binding site [chemical binding]; other site 264731007616 Walker B motif; other site 264731007617 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 264731007618 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264731007619 Clostripain family; Region: Peptidase_C11; pfam03415 264731007620 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731007621 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 264731007622 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 264731007623 L-fucose isomerase; Provisional; Region: fucI; PRK10991 264731007624 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 264731007625 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264731007626 trimer interface [polypeptide binding]; other site 264731007627 substrate binding site [chemical binding]; other site 264731007628 Mn binding site [ion binding]; other site 264731007629 Domain of unknown function (DUF718); Region: DUF718; pfam05336 264731007630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264731007632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264731007633 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 264731007634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731007635 FeS/SAM binding site; other site 264731007636 HemN C-terminal domain; Region: HemN_C; pfam06969 264731007637 protoporphyrinogen oxidase; Region: PLN02576 264731007638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264731007639 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264731007640 PA14 domain; Region: PA14; cl08459 264731007641 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 264731007642 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264731007643 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 264731007644 FMN binding site [chemical binding]; other site 264731007645 dimer interface [polypeptide binding]; other site 264731007646 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264731007647 catalytic residues [active] 264731007648 dimer interface [polypeptide binding]; other site 264731007649 MarR family; Region: MarR_2; cl17246 264731007650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264731007651 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264731007652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264731007653 putative DNA binding site [nucleotide binding]; other site 264731007654 putative Zn2+ binding site [ion binding]; other site 264731007655 AsnC family; Region: AsnC_trans_reg; pfam01037 264731007656 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 264731007657 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264731007658 homodimer interface [polypeptide binding]; other site 264731007659 substrate-cofactor binding pocket; other site 264731007660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731007661 catalytic residue [active] 264731007662 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264731007663 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264731007664 dimer interface [polypeptide binding]; other site 264731007665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731007666 catalytic residue [active] 264731007667 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 264731007668 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 264731007669 catalytic core [active] 264731007670 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731007671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007672 binding surface 264731007673 TPR motif; other site 264731007674 Helix-turn-helix domain; Region: HTH_18; pfam12833 264731007675 flavodoxin FldA; Validated; Region: PRK09267 264731007676 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 264731007677 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264731007678 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 264731007679 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 264731007680 Imelysin; Region: Peptidase_M75; pfam09375 264731007681 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264731007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264731007683 active site 264731007684 phosphorylation site [posttranslational modification] 264731007685 intermolecular recognition site; other site 264731007686 dimerization interface [polypeptide binding]; other site 264731007687 LytTr DNA-binding domain; Region: LytTR; pfam04397 264731007688 Histidine kinase; Region: His_kinase; pfam06580 264731007689 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 264731007690 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 264731007691 WYL domain; Region: WYL; pfam13280 264731007692 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 264731007693 active site 264731007694 catalytic site [active] 264731007695 substrate binding site [chemical binding]; other site 264731007696 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 264731007697 Fic/DOC family; Region: Fic; pfam02661 264731007698 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264731007699 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264731007700 Walker A motif; other site 264731007701 ATP binding site [chemical binding]; other site 264731007702 Walker B motif; other site 264731007703 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264731007704 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731007705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264731007706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264731007707 DNA binding residues [nucleotide binding] 264731007708 dimerization interface [polypeptide binding]; other site 264731007709 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 264731007710 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264731007711 putative ATP binding site [chemical binding]; other site 264731007712 putative substrate interface [chemical binding]; other site 264731007713 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 264731007714 Cna protein B-type domain; Region: Cna_B_2; pfam13715 264731007715 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 264731007716 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 264731007717 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 264731007718 starch binding outer membrane protein SusD; Region: SusD; cd08977 264731007719 OsmC-like protein; Region: OsmC; pfam02566 264731007720 OsmC-like protein; Region: OsmC; pfam02566 264731007721 OsmC-like protein; Region: OsmC; pfam02566 264731007722 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 264731007723 YtkA-like; Region: YtkA; pfam13115 264731007724 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 264731007725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007726 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264731007727 homotrimer interaction site [polypeptide binding]; other site 264731007728 putative active site [active] 264731007729 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264731007730 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264731007731 catalytic residues [active] 264731007732 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264731007733 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264731007734 active site 264731007735 HIGH motif; other site 264731007736 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264731007737 KMSKS motif; other site 264731007738 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264731007739 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 264731007740 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 264731007741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264731007742 putative substrate translocation pore; other site 264731007743 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 264731007744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264731007745 putative NAD(P) binding site [chemical binding]; other site 264731007746 catalytic Zn binding site [ion binding]; other site 264731007747 structural Zn binding site [ion binding]; other site 264731007748 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264731007749 Amidohydrolase; Region: Amidohydro_2; pfam04909 264731007750 active site 264731007751 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264731007752 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264731007753 active site 264731007754 catalytic tetrad [active] 264731007755 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 264731007756 active site 264731007757 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 264731007758 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 264731007759 Substrate-binding site [chemical binding]; other site 264731007760 Substrate specificity [chemical binding]; other site 264731007761 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 264731007762 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 264731007763 Substrate-binding site [chemical binding]; other site 264731007764 Substrate specificity [chemical binding]; other site 264731007765 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264731007766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264731007767 Peptidase family U32; Region: Peptidase_U32; pfam01136 264731007768 NMT1/THI5 like; Region: NMT1; pfam09084 264731007769 Cache domain; Region: Cache_1; pfam02743 264731007770 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264731007771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264731007772 dimerization interface [polypeptide binding]; other site 264731007773 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264731007774 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 264731007775 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 264731007776 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 264731007777 ATP cone domain; Region: ATP-cone; pfam03477 264731007778 Class III ribonucleotide reductase; Region: RNR_III; cd01675 264731007779 effector binding site; other site 264731007780 active site 264731007781 Zn binding site [ion binding]; other site 264731007782 glycine loop; other site 264731007783 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 264731007784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731007785 FeS/SAM binding site; other site 264731007786 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 264731007787 catalytic core [active] 264731007788 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264731007789 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264731007790 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264731007791 AIR carboxylase; Region: AIRC; pfam00731 264731007792 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264731007793 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264731007794 NAD-dependent deacetylase; Provisional; Region: PRK00481 264731007795 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 264731007796 NAD+ binding site [chemical binding]; other site 264731007797 substrate binding site [chemical binding]; other site 264731007798 Zn binding site [ion binding]; other site 264731007799 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264731007800 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264731007801 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264731007802 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264731007803 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 264731007804 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264731007805 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264731007806 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 264731007807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264731007808 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 264731007809 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 264731007810 AsnC family; Region: AsnC_trans_reg; pfam01037 264731007811 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 264731007812 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264731007813 catalytic triad [active] 264731007814 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 264731007815 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 264731007816 active site 264731007817 dimer interface [polypeptide binding]; other site 264731007818 M28 Zn-Peptidases; Region: M28_like_6; cd08656 264731007819 Peptidase family M28; Region: Peptidase_M28; pfam04389 264731007820 metal binding site [ion binding]; metal-binding site 264731007821 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 264731007822 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 264731007823 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264731007824 putative substrate binding site [chemical binding]; other site 264731007825 putative ATP binding site [chemical binding]; other site 264731007826 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264731007827 active site 264731007828 adenylate kinase; Reviewed; Region: adk; PRK00279 264731007829 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264731007830 AMP-binding site [chemical binding]; other site 264731007831 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264731007832 GTPase CgtA; Reviewed; Region: obgE; PRK12298 264731007833 GTP1/OBG; Region: GTP1_OBG; pfam01018 264731007834 Obg GTPase; Region: Obg; cd01898 264731007835 G1 box; other site 264731007836 GTP/Mg2+ binding site [chemical binding]; other site 264731007837 Switch I region; other site 264731007838 G2 box; other site 264731007839 G3 box; other site 264731007840 Switch II region; other site 264731007841 G4 box; other site 264731007842 G5 box; other site 264731007843 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 264731007844 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 264731007845 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 264731007846 active site 264731007847 substrate binding site [chemical binding]; other site 264731007848 Mg2+ binding site [ion binding]; other site 264731007849 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 264731007850 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264731007851 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264731007852 glycyl-tRNA synthetase; Provisional; Region: PRK04173 264731007853 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264731007854 motif 1; other site 264731007855 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 264731007856 active site 264731007857 motif 2; other site 264731007858 motif 3; other site 264731007859 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 264731007860 anticodon binding site; other site 264731007861 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264731007862 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 264731007863 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 264731007864 ligand binding site [chemical binding]; other site 264731007865 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 264731007866 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 264731007867 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 264731007868 TrkA-N domain; Region: TrkA_N; pfam02254 264731007869 TrkA-C domain; Region: TrkA_C; pfam02080 264731007870 TrkA-N domain; Region: TrkA_N; pfam02254 264731007871 TrkA-C domain; Region: TrkA_C; pfam02080 264731007872 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264731007873 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264731007874 TPP-binding site; other site 264731007875 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264731007876 PYR/PP interface [polypeptide binding]; other site 264731007877 dimer interface [polypeptide binding]; other site 264731007878 TPP binding site [chemical binding]; other site 264731007879 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264731007880 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 264731007881 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 264731007882 HsdM N-terminal domain; Region: HsdM_N; pfam12161 264731007883 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 264731007884 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264731007885 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264731007886 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264731007887 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264731007888 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 264731007889 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264731007890 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 264731007891 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 264731007892 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 264731007893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264731007894 ATP binding site [chemical binding]; other site 264731007895 putative Mg++ binding site [ion binding]; other site 264731007896 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 264731007897 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 264731007898 BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative...; Region: BPI; cl00188 264731007899 Peptidase M15; Region: Peptidase_M15_3; cl01194 264731007900 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264731007901 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264731007902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264731007903 Predicted membrane protein [Function unknown]; Region: COG2246 264731007904 GtrA-like protein; Region: GtrA; pfam04138 264731007905 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 264731007906 putative active site [active] 264731007907 putative catalytic site [active] 264731007908 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264731007909 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264731007910 Ligand binding site; other site 264731007911 Putative Catalytic site; other site 264731007912 DXD motif; other site 264731007913 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 264731007914 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 264731007915 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 264731007916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264731007917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264731007918 homodimer interface [polypeptide binding]; other site 264731007919 catalytic residue [active] 264731007920 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264731007921 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 264731007922 active site 264731007923 metal-binding site 264731007924 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264731007925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264731007926 active site 264731007927 LicD family; Region: LicD; pfam04991 264731007928 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264731007929 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 264731007930 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264731007931 putative acyl-acceptor binding pocket; other site 264731007932 Sulfatase; Region: Sulfatase; pfam00884 264731007933 Sulfatase; Region: Sulfatase; cl17466 264731007934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264731007935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264731007936 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 264731007937 Walker A/P-loop; other site 264731007938 ATP binding site [chemical binding]; other site 264731007939 Q-loop/lid; other site 264731007940 ABC transporter signature motif; other site 264731007941 Walker B; other site 264731007942 D-loop; other site 264731007943 H-loop/switch region; other site 264731007944 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 264731007945 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264731007946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264731007947 FeS/SAM binding site; other site 264731007948 TRAM domain; Region: TRAM; pfam01938 264731007949 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 264731007950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 264731007951 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264731007952 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264731007953 trimer interface [polypeptide binding]; other site 264731007954 active site 264731007955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007956 binding surface 264731007957 TPR motif; other site 264731007958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264731007959 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264731007960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007961 TPR motif; other site 264731007962 binding surface 264731007963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264731007964 TPR motif; other site 264731007965 binding surface 264731007966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264731007967 TPR motif; other site 264731007968 binding surface 264731007969 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 264731007970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 264731007971 Peptidase family M23; Region: Peptidase_M23; pfam01551 264731007972 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 264731007973 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 264731007974 metal binding site [ion binding]; metal-binding site 264731007975 dimer interface [polypeptide binding]; other site 264731007976 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 264731007977 Competence protein; Region: Competence; pfam03772 264731007978 Predicted permeases [General function prediction only]; Region: COG0679 264731007979 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264731007980 RIP metalloprotease RseP; Region: TIGR00054 264731007981 active site 264731007982 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264731007983 protein binding site [polypeptide binding]; other site 264731007984 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264731007985 putative substrate binding region [chemical binding]; other site 264731007986 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264731007987 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264731007988 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264731007989 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264731007990 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264731007991 RimM N-terminal domain; Region: RimM; pfam01782 264731007992 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264731007993 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264731007994 hinge; other site 264731007995 active site 264731007996 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 264731007997 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264731007998 Glycoprotease family; Region: Peptidase_M22; pfam00814 264731007999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264731008000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264731008001 phosphorylation site [posttranslational modification] 264731008002 dimer interface [polypeptide binding]; other site 264731008003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264731008004 ATP binding site [chemical binding]; other site 264731008005 Mg2+ binding site [ion binding]; other site 264731008006 G-X-G motif; other site 264731008007 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 264731008008 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 264731008009 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264731008010 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264731008011 dimer interface [polypeptide binding]; other site 264731008012 active site 264731008013 CoA binding pocket [chemical binding]; other site 264731008014 GTPase Era; Reviewed; Region: era; PRK00089 264731008015 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264731008016 G1 box; other site 264731008017 GTP/Mg2+ binding site [chemical binding]; other site 264731008018 Switch I region; other site 264731008019 G2 box; other site 264731008020 Switch II region; other site 264731008021 G3 box; other site 264731008022 G4 box; other site 264731008023 G5 box; other site 264731008024 KH domain; Region: KH_2; pfam07650 264731008025 GTP-binding protein Der; Reviewed; Region: PRK00093 264731008026 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264731008027 G1 box; other site 264731008028 GTP/Mg2+ binding site [chemical binding]; other site 264731008029 Switch I region; other site 264731008030 G2 box; other site 264731008031 Switch II region; other site 264731008032 G3 box; other site 264731008033 G4 box; other site 264731008034 G5 box; other site 264731008035 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264731008036 G1 box; other site 264731008037 GTP/Mg2+ binding site [chemical binding]; other site 264731008038 Switch I region; other site 264731008039 G2 box; other site 264731008040 G3 box; other site 264731008041 Switch II region; other site 264731008042 G4 box; other site 264731008043 G5 box; other site 264731008044 Lumazine-binding domain; Region: Lumazine_bd; pfam12870