-- dump date 20140619_235946 -- class Genbank::misc_feature -- table misc_feature_note -- id note 146891000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 146891000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 146891000003 putative DNA binding surface [nucleotide binding]; other site 146891000004 dimer interface [polypeptide binding]; other site 146891000005 beta-clamp/clamp loader binding surface; other site 146891000006 beta-clamp/translesion DNA polymerase binding surface; other site 146891000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 146891000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 146891000009 dimerization interface [polypeptide binding]; other site 146891000010 ATP binding site [chemical binding]; other site 146891000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 146891000012 dimerization interface [polypeptide binding]; other site 146891000013 ATP binding site [chemical binding]; other site 146891000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 146891000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 146891000016 active site 146891000017 tetramer interface [polypeptide binding]; other site 146891000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891000019 active site 146891000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 146891000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 146891000022 CAP-like domain; other site 146891000023 active site 146891000024 primary dimer interface [polypeptide binding]; other site 146891000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000026 binding surface 146891000027 TPR motif; other site 146891000028 TPR repeat; Region: TPR_11; pfam13414 146891000029 TPR repeat; Region: TPR_11; pfam13414 146891000030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000031 binding surface 146891000032 TPR motif; other site 146891000033 TPR repeat; Region: TPR_11; pfam13414 146891000034 TPR repeat; Region: TPR_11; pfam13414 146891000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 146891000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 146891000037 Uncharacterized conserved protein [Function unknown]; Region: COG2928 146891000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 146891000039 putative RNA binding site [nucleotide binding]; other site 146891000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 146891000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 146891000042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891000043 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 146891000044 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 146891000045 argininosuccinate lyase; Provisional; Region: PRK00855 146891000046 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 146891000047 active sites [active] 146891000048 tetramer interface [polypeptide binding]; other site 146891000049 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 146891000050 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 146891000051 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 146891000052 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 146891000053 FMN binding site [chemical binding]; other site 146891000054 active site 146891000055 catalytic residues [active] 146891000056 substrate binding site [chemical binding]; other site 146891000057 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 146891000058 SelR domain; Region: SelR; pfam01641 146891000059 GrpE; Region: GrpE; pfam01025 146891000060 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 146891000061 dimer interface [polypeptide binding]; other site 146891000062 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 146891000063 chaperone protein DnaJ; Provisional; Region: PRK14293 146891000064 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891000065 HSP70 interaction site [polypeptide binding]; other site 146891000066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 146891000067 substrate binding site [polypeptide binding]; other site 146891000068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 146891000069 Zn binding sites [ion binding]; other site 146891000070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 146891000071 dimer interface [polypeptide binding]; other site 146891000072 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 146891000073 CPxP motif; other site 146891000074 Predicted GTPases [General function prediction only]; Region: COG1162 146891000075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 146891000076 RNA binding site [nucleotide binding]; other site 146891000077 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 146891000078 GTPase/Zn-binding domain interface [polypeptide binding]; other site 146891000079 GTP/Mg2+ binding site [chemical binding]; other site 146891000080 G4 box; other site 146891000081 G5 box; other site 146891000082 G1 box; other site 146891000083 Switch I region; other site 146891000084 G2 box; other site 146891000085 G3 box; other site 146891000086 Switch II region; other site 146891000087 hypothetical protein; Validated; Region: PRK00153 146891000088 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 146891000089 FAD binding domain; Region: FAD_binding_4; pfam01565 146891000090 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 146891000091 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 146891000092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891000093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 146891000094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 146891000095 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 146891000096 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 146891000097 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 146891000098 thiamine monophosphate kinase; Provisional; Region: PRK05731 146891000099 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 146891000100 ATP binding site [chemical binding]; other site 146891000101 dimerization interface [polypeptide binding]; other site 146891000102 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 146891000103 active site 146891000104 elongation factor P; Validated; Region: PRK00529 146891000105 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 146891000106 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 146891000107 RNA binding site [nucleotide binding]; other site 146891000108 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 146891000109 RNA binding site [nucleotide binding]; other site 146891000110 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 146891000111 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 146891000112 carboxyltransferase (CT) interaction site; other site 146891000113 biotinylation site [posttranslational modification]; other site 146891000114 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 146891000115 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 146891000116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891000117 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 146891000118 putative NAD(P) binding site [chemical binding]; other site 146891000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 146891000120 active site 146891000121 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 146891000122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 146891000123 homodimer interface [polypeptide binding]; other site 146891000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000125 catalytic residue [active] 146891000126 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 146891000127 GMP synthase; Reviewed; Region: guaA; PRK00074 146891000128 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 146891000129 AMP/PPi binding site [chemical binding]; other site 146891000130 candidate oxyanion hole; other site 146891000131 catalytic triad [active] 146891000132 potential glutamine specificity residues [chemical binding]; other site 146891000133 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 146891000134 ATP Binding subdomain [chemical binding]; other site 146891000135 Ligand Binding sites [chemical binding]; other site 146891000136 Dimerization subdomain; other site 146891000137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000138 TPR motif; other site 146891000139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 146891000140 binding surface 146891000141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000142 binding surface 146891000143 TPR motif; other site 146891000144 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 146891000145 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 146891000146 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 146891000147 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 146891000148 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 146891000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 146891000150 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 146891000151 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 146891000152 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 146891000153 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 146891000154 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 146891000155 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 146891000156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 146891000157 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 146891000158 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 146891000159 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 146891000160 motif 1; other site 146891000161 active site 146891000162 motif 2; other site 146891000163 motif 3; other site 146891000164 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 146891000165 DHHA1 domain; Region: DHHA1; pfam02272 146891000166 arginine decarboxylase; Provisional; Region: PRK05354 146891000167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 146891000168 dimer interface [polypeptide binding]; other site 146891000169 active site 146891000170 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891000171 catalytic residues [active] 146891000172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 146891000173 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 146891000174 active site 146891000175 multimer interface [polypeptide binding]; other site 146891000176 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 146891000177 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 146891000178 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 146891000179 GatB domain; Region: GatB_Yqey; smart00845 146891000180 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 146891000181 dephospho-CoA kinase; Region: TIGR00152 146891000182 CoA-binding site [chemical binding]; other site 146891000183 ATP-binding [chemical binding]; other site 146891000184 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 146891000185 heterotetramer interface [polypeptide binding]; other site 146891000186 active site pocket [active] 146891000187 cleavage site 146891000188 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 146891000189 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 146891000190 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 146891000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891000192 ATP binding site [chemical binding]; other site 146891000193 putative Mg++ binding site [ion binding]; other site 146891000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891000195 nucleotide binding region [chemical binding]; other site 146891000196 ATP-binding site [chemical binding]; other site 146891000197 Helicase associated domain; Region: HA; pfam03457 146891000198 Helicase associated domain; Region: HA; pfam03457 146891000199 Helicase associated domain; Region: HA; pfam03457 146891000200 Helicase associated domain; Region: HA; pfam03457 146891000201 Helicase associated domain; Region: HA; pfam03457 146891000202 Helicase associated domain; Region: HA; pfam03457 146891000203 Helicase associated domain; Region: HA; pfam03457 146891000204 Helicase associated domain; Region: HA; pfam03457 146891000205 Helicase associated domain; Region: HA; pfam03457 146891000206 Helicase associated domain; Region: HA; pfam03457 146891000207 Helicase associated domain; Region: HA; pfam03457 146891000208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000209 TPR repeat; Region: TPR_11; pfam13414 146891000210 TPR motif; other site 146891000211 binding surface 146891000212 TPR repeat; Region: TPR_11; pfam13414 146891000213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000214 TPR motif; other site 146891000215 binding surface 146891000216 TPR repeat; Region: TPR_11; pfam13414 146891000217 YadA-like C-terminal region; Region: YadA; pfam03895 146891000218 ParA-like protein; Provisional; Region: PHA02518 146891000219 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 146891000220 P-loop; other site 146891000221 Magnesium ion binding site [ion binding]; other site 146891000222 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 146891000223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 146891000224 active site 146891000225 catalytic tetrad [active] 146891000226 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 146891000227 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 146891000228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 146891000229 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 146891000230 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 146891000231 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 146891000232 Walker A/P-loop; other site 146891000233 ATP binding site [chemical binding]; other site 146891000234 Q-loop/lid; other site 146891000235 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 146891000236 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 146891000237 ABC transporter signature motif; other site 146891000238 Walker B; other site 146891000239 D-loop; other site 146891000240 H-loop/switch region; other site 146891000241 PRC-barrel domain; Region: PRC; pfam05239 146891000242 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 146891000243 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 146891000244 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891000245 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 146891000246 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 146891000247 YGGT family; Region: YGGT; pfam02325 146891000248 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 146891000249 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 146891000250 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 146891000251 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 146891000252 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 146891000253 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 146891000254 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 146891000255 nucleotide binding site/active site [active] 146891000256 HIT family signature motif; other site 146891000257 catalytic residue [active] 146891000258 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 146891000259 active site 146891000260 catalytic residues [active] 146891000261 metal binding site [ion binding]; metal-binding site 146891000262 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 146891000263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 146891000264 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 146891000265 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 146891000266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891000267 catalytic residue [active] 146891000268 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 146891000269 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 146891000270 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 146891000271 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 146891000272 Walker A/P-loop; other site 146891000273 ATP binding site [chemical binding]; other site 146891000274 Q-loop/lid; other site 146891000275 ABC transporter signature motif; other site 146891000276 Walker B; other site 146891000277 D-loop; other site 146891000278 H-loop/switch region; other site 146891000279 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 146891000280 putative ABC transporter; Region: ycf24; CHL00085 146891000281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 146891000282 phosphoglucomutase; Region: PLN02307 146891000283 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 146891000284 active site 146891000285 substrate binding site [chemical binding]; other site 146891000286 metal binding site [ion binding]; metal-binding site 146891000287 recombination factor protein RarA; Reviewed; Region: PRK13342 146891000288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000289 Walker A motif; other site 146891000290 ATP binding site [chemical binding]; other site 146891000291 Walker B motif; other site 146891000292 arginine finger; other site 146891000293 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 146891000294 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 146891000295 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 146891000296 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891000297 catalytic triad [active] 146891000298 Type III pantothenate kinase; Region: Pan_kinase; cl17198 146891000299 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 146891000300 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 146891000301 Active Sites [active] 146891000302 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 146891000303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 146891000304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 146891000305 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 146891000306 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 146891000307 transmembrane helices; other site 146891000308 TrkA-C domain; Region: TrkA_C; pfam02080 146891000309 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 146891000310 TrkA-C domain; Region: TrkA_C; pfam02080 146891000311 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 146891000312 Cation transport protein; Region: TrkH; cl17365 146891000313 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 146891000314 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 146891000315 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 146891000316 TrkA-N domain; Region: TrkA_N; pfam02254 146891000317 TrkA-C domain; Region: TrkA_C; pfam02080 146891000318 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 146891000319 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 146891000320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891000321 Walker A/P-loop; other site 146891000322 ATP binding site [chemical binding]; other site 146891000323 Q-loop/lid; other site 146891000324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 146891000325 ABC transporter signature motif; other site 146891000326 Walker B; other site 146891000327 D-loop; other site 146891000328 ABC transporter; Region: ABC_tran_2; pfam12848 146891000329 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 146891000330 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 146891000331 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 146891000332 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 146891000333 protein binding site [polypeptide binding]; other site 146891000334 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 146891000335 putative high light inducible protein; Region: PHA02337 146891000336 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 146891000337 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 146891000338 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 146891000339 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 146891000340 active site 146891000341 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 146891000342 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 146891000343 Protein of unknown function (DUF512); Region: DUF512; pfam04459 146891000344 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 146891000345 L-aspartate oxidase; Provisional; Region: PRK06175 146891000346 L-aspartate oxidase; Provisional; Region: PRK07395 146891000347 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 146891000348 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 146891000349 substrate binding site [chemical binding]; other site 146891000350 putative active site [active] 146891000351 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891000352 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 146891000353 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 146891000354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891000355 FeS/SAM binding site; other site 146891000356 TRAM domain; Region: TRAM; cl01282 146891000357 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 146891000358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 146891000359 Protein of unknown function, DUF482; Region: DUF482; pfam04339 146891000360 RibD C-terminal domain; Region: RibD_C; cl17279 146891000361 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 146891000362 active site 146891000363 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 146891000364 active site 146891000365 shikimate kinase; Reviewed; Region: aroK; PRK00131 146891000366 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 146891000367 ADP binding site [chemical binding]; other site 146891000368 magnesium binding site [ion binding]; other site 146891000369 putative shikimate binding site; other site 146891000370 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 146891000371 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 146891000372 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 146891000373 C-terminal domain interface [polypeptide binding]; other site 146891000374 GSH binding site (G-site) [chemical binding]; other site 146891000375 dimer interface [polypeptide binding]; other site 146891000376 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 146891000377 N-terminal domain interface [polypeptide binding]; other site 146891000378 dimer interface [polypeptide binding]; other site 146891000379 substrate binding pocket (H-site) [chemical binding]; other site 146891000380 Protein of unknown function (DUF751); Region: DUF751; pfam05421 146891000381 Ribosome-binding factor A; Region: RBFA; pfam02033 146891000382 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 146891000383 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 146891000384 active site 146891000385 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 146891000386 putative hydrophobic ligand binding site [chemical binding]; other site 146891000387 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 146891000388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891000389 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 146891000390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000391 TPR motif; other site 146891000392 binding surface 146891000393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 146891000394 conserved hypothetical protein; Region: TIGR03492 146891000395 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 146891000396 TIGR01777 family protein; Region: yfcH 146891000397 putative NAD(P) binding site [chemical binding]; other site 146891000398 putative active site [active] 146891000399 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 146891000400 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891000401 HSP70 interaction site [polypeptide binding]; other site 146891000402 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 146891000403 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 146891000404 dimer interface [polypeptide binding]; other site 146891000405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000406 catalytic residue [active] 146891000407 hypothetical protein; Provisional; Region: PRK13683 146891000408 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891000409 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 146891000410 Walker A/P-loop; other site 146891000411 ATP binding site [chemical binding]; other site 146891000412 Q-loop/lid; other site 146891000413 ABC transporter signature motif; other site 146891000414 Walker B; other site 146891000415 D-loop; other site 146891000416 H-loop/switch region; other site 146891000417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 146891000418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000419 active site 146891000420 phosphorylation site [posttranslational modification] 146891000421 intermolecular recognition site; other site 146891000422 dimerization interface [polypeptide binding]; other site 146891000423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891000424 DNA binding site [nucleotide binding] 146891000425 DNA polymerase III subunit delta'; Validated; Region: PRK07399 146891000426 DNA polymerase III subunit delta'; Validated; Region: PRK08485 146891000427 thymidylate kinase; Validated; Region: tmk; PRK00698 146891000428 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 146891000429 TMP-binding site; other site 146891000430 ATP-binding site [chemical binding]; other site 146891000431 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 146891000432 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 146891000433 metal-binding site [ion binding] 146891000434 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 146891000435 Soluble P-type ATPase [General function prediction only]; Region: COG4087 146891000436 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 146891000437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000438 binding surface 146891000439 TPR motif; other site 146891000440 DNA repair protein RadA; Provisional; Region: PRK11823 146891000441 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 146891000442 Walker A motif; other site 146891000443 ATP binding site [chemical binding]; other site 146891000444 Walker B motif; other site 146891000445 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 146891000446 Ycf27; Reviewed; Region: orf27; CHL00148 146891000447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000448 active site 146891000449 phosphorylation site [posttranslational modification] 146891000450 intermolecular recognition site; other site 146891000451 dimerization interface [polypeptide binding]; other site 146891000452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891000453 DNA binding site [nucleotide binding] 146891000454 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 146891000455 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 146891000456 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 146891000457 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 146891000458 dimer interface [polypeptide binding]; other site 146891000459 active site 146891000460 CoA binding pocket [chemical binding]; other site 146891000461 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 146891000462 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 146891000463 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 146891000464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 146891000465 putative acyl-acceptor binding pocket; other site 146891000466 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 146891000467 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 146891000468 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 146891000469 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 146891000470 active site 146891000471 NTP binding site [chemical binding]; other site 146891000472 metal binding triad [ion binding]; metal-binding site 146891000473 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 146891000474 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 146891000475 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 146891000476 active site lid residues [active] 146891000477 substrate binding pocket [chemical binding]; other site 146891000478 catalytic residues [active] 146891000479 substrate-Mg2+ binding site; other site 146891000480 aspartate-rich region 1; other site 146891000481 aspartate-rich region 2; other site 146891000482 phytoene desaturase; Region: phytoene_desat; TIGR02731 146891000483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891000484 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 146891000485 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 146891000486 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 146891000487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 146891000488 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 146891000489 putative dimerization interface [polypeptide binding]; other site 146891000490 NnrU protein; Region: NnrU; cl17713 146891000491 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 146891000492 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 146891000493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 146891000494 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 146891000495 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 146891000496 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 146891000497 ScpA/B protein; Region: ScpA_ScpB; cl00598 146891000498 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 146891000499 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 146891000500 active site 146891000501 Substrate binding site; other site 146891000502 Mg++ binding site; other site 146891000503 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 146891000504 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 146891000505 FAD binding site [chemical binding]; other site 146891000506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 146891000507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 146891000508 DNA binding residues [nucleotide binding] 146891000509 dimerization interface [polypeptide binding]; other site 146891000510 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 146891000511 putative active site [active] 146891000512 putative metal binding residues [ion binding]; other site 146891000513 signature motif; other site 146891000514 putative dimer interface [polypeptide binding]; other site 146891000515 putative phosphate binding site [ion binding]; other site 146891000516 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 146891000517 ATP-NAD kinase; Region: NAD_kinase; pfam01513 146891000518 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 146891000519 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 146891000520 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 146891000521 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 146891000522 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 146891000523 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 146891000524 NADH dehydrogenase; Region: NADHdh; cl00469 146891000525 citrate synthase; Provisional; Region: PRK14036 146891000526 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 146891000527 oxalacetate binding site [chemical binding]; other site 146891000528 citrylCoA binding site [chemical binding]; other site 146891000529 coenzyme A binding site [chemical binding]; other site 146891000530 catalytic triad [active] 146891000531 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 146891000532 active site residue [active] 146891000533 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 146891000534 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 146891000535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000536 catalytic residue [active] 146891000537 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 146891000538 putative rRNA binding site [nucleotide binding]; other site 146891000539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891000540 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 146891000541 Walker A/P-loop; other site 146891000542 ligand-binding site [chemical binding]; other site 146891000543 ATP binding site [chemical binding]; other site 146891000544 AIR carboxylase; Region: AIRC; pfam00731 146891000545 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 146891000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891000547 S-adenosylmethionine binding site [chemical binding]; other site 146891000548 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 146891000549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 146891000550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000551 active site 146891000552 phosphorylation site [posttranslational modification] 146891000553 intermolecular recognition site; other site 146891000554 dimerization interface [polypeptide binding]; other site 146891000555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 146891000556 DNA binding residues [nucleotide binding] 146891000557 dimerization interface [polypeptide binding]; other site 146891000558 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 146891000559 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 146891000560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891000561 catalytic residue [active] 146891000562 MraW methylase family; Region: Methyltransf_5; cl17771 146891000563 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 146891000564 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 146891000565 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 146891000566 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 146891000567 active site 146891000568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 146891000569 acyl-activating enzyme (AAE) consensus motif; other site 146891000570 active site 146891000571 AMP binding site [chemical binding]; other site 146891000572 CoA binding site [chemical binding]; other site 146891000573 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 146891000574 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 146891000575 active site 146891000576 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 146891000577 UbiA prenyltransferase family; Region: UbiA; pfam01040 146891000578 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 146891000579 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 146891000580 glutathione synthetase; Provisional; Region: PRK05246 146891000581 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 146891000582 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 146891000583 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 146891000584 GSH binding site [chemical binding]; other site 146891000585 catalytic residues [active] 146891000586 peptide chain release factor 2; Validated; Region: prfB; PRK00578 146891000587 PCRF domain; Region: PCRF; pfam03462 146891000588 RF-1 domain; Region: RF-1; pfam00472 146891000589 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 146891000590 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 146891000591 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 146891000592 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 146891000593 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 146891000594 glutamine binding [chemical binding]; other site 146891000595 catalytic triad [active] 146891000596 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 146891000597 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 146891000598 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 146891000599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891000600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000601 homodimer interface [polypeptide binding]; other site 146891000602 catalytic residue [active] 146891000603 arginine-tRNA ligase; Region: PLN02286 146891000604 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 146891000605 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 146891000606 active site 146891000607 HIGH motif; other site 146891000608 KMSK motif region; other site 146891000609 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 146891000610 tRNA binding surface [nucleotide binding]; other site 146891000611 anticodon binding site; other site 146891000612 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 146891000613 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 146891000614 dimerization interface [polypeptide binding]; other site 146891000615 active site 146891000616 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 146891000617 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 146891000618 trmE is a tRNA modification GTPase; Region: trmE; cd04164 146891000619 G1 box; other site 146891000620 GTP/Mg2+ binding site [chemical binding]; other site 146891000621 Switch I region; other site 146891000622 G2 box; other site 146891000623 Switch II region; other site 146891000624 G3 box; other site 146891000625 G4 box; other site 146891000626 G5 box; other site 146891000627 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 146891000628 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 146891000629 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 146891000630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 146891000631 Zn2+ binding site [ion binding]; other site 146891000632 Mg2+ binding site [ion binding]; other site 146891000633 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 146891000634 synthetase active site [active] 146891000635 NTP binding site [chemical binding]; other site 146891000636 metal binding site [ion binding]; metal-binding site 146891000637 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 146891000638 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 146891000639 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 146891000640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 146891000641 Walker A/P-loop; other site 146891000642 ATP binding site [chemical binding]; other site 146891000643 Q-loop/lid; other site 146891000644 ABC transporter signature motif; other site 146891000645 Walker B; other site 146891000646 D-loop; other site 146891000647 H-loop/switch region; other site 146891000648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 146891000649 Walker A/P-loop; other site 146891000650 ATP binding site [chemical binding]; other site 146891000651 Q-loop/lid; other site 146891000652 ABC transporter signature motif; other site 146891000653 Walker B; other site 146891000654 D-loop; other site 146891000655 H-loop/switch region; other site 146891000656 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 146891000657 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891000658 RNA binding surface [nucleotide binding]; other site 146891000659 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 146891000660 active site 146891000661 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 146891000662 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 146891000663 GTP/Mg2+ binding site [chemical binding]; other site 146891000664 G4 box; other site 146891000665 G5 box; other site 146891000666 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 146891000667 G1 box; other site 146891000668 G1 box; other site 146891000669 GTP/Mg2+ binding site [chemical binding]; other site 146891000670 Switch I region; other site 146891000671 G2 box; other site 146891000672 G2 box; other site 146891000673 G3 box; other site 146891000674 G3 box; other site 146891000675 Switch II region; other site 146891000676 Switch II region; other site 146891000677 G4 box; other site 146891000678 Phosphoglycerate kinase; Region: PGK; pfam00162 146891000679 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 146891000680 substrate binding site [chemical binding]; other site 146891000681 hinge regions; other site 146891000682 ADP binding site [chemical binding]; other site 146891000683 catalytic site [active] 146891000684 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 146891000685 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 146891000686 active site 146891000687 homodimer interface [polypeptide binding]; other site 146891000688 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 146891000689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891000690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000691 homodimer interface [polypeptide binding]; other site 146891000692 catalytic residue [active] 146891000693 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 146891000694 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 146891000695 active site 146891000696 catalytic residues [active] 146891000697 FMN binding site [chemical binding]; other site 146891000698 quinone interaction residues [chemical binding]; other site 146891000699 substrate binding site [chemical binding]; other site 146891000700 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 146891000701 RNA/DNA hybrid binding site [nucleotide binding]; other site 146891000702 active site 146891000703 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 146891000704 L11 interface [polypeptide binding]; other site 146891000705 putative EF-Tu interaction site [polypeptide binding]; other site 146891000706 putative EF-G interaction site [polypeptide binding]; other site 146891000707 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 146891000708 23S rRNA interface [nucleotide binding]; other site 146891000709 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 146891000710 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 146891000711 mRNA/rRNA interface [nucleotide binding]; other site 146891000712 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 146891000713 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 146891000714 23S rRNA interface [nucleotide binding]; other site 146891000715 L7/L12 interface [polypeptide binding]; other site 146891000716 putative thiostrepton binding site; other site 146891000717 L25 interface [polypeptide binding]; other site 146891000718 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 146891000719 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 146891000720 putative homodimer interface [polypeptide binding]; other site 146891000721 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 146891000722 heterodimer interface [polypeptide binding]; other site 146891000723 homodimer interface [polypeptide binding]; other site 146891000724 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 146891000725 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 146891000726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000727 Walker A motif; other site 146891000728 ATP binding site [chemical binding]; other site 146891000729 Walker B motif; other site 146891000730 arginine finger; other site 146891000731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000732 Walker A motif; other site 146891000733 ATP binding site [chemical binding]; other site 146891000734 Walker B motif; other site 146891000735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 146891000736 enolase; Provisional; Region: eno; PRK00077 146891000737 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 146891000738 dimer interface [polypeptide binding]; other site 146891000739 metal binding site [ion binding]; metal-binding site 146891000740 substrate binding pocket [chemical binding]; other site 146891000741 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 146891000742 ABC1 family; Region: ABC1; cl17513 146891000743 ABC1 family; Region: ABC1; cl17513 146891000744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 146891000745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891000746 Nitrogen regulatory protein P-II; Region: P-II; cl00412 146891000747 Domain of unknown function (DUF897); Region: DUF897; pfam05982 146891000748 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 146891000749 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 146891000750 Sulfate transporter family; Region: Sulfate_transp; pfam00916 146891000751 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 146891000752 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 146891000753 dimer interface [polypeptide binding]; other site 146891000754 allosteric magnesium binding site [ion binding]; other site 146891000755 active site 146891000756 aspartate-rich active site metal binding site; other site 146891000757 Schiff base residues; other site 146891000758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 146891000759 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 146891000760 active site 146891000761 metal binding site [ion binding]; metal-binding site 146891000762 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 146891000763 MutS domain III; Region: MutS_III; pfam05192 146891000764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891000765 Walker A/P-loop; other site 146891000766 ATP binding site [chemical binding]; other site 146891000767 Q-loop/lid; other site 146891000768 ABC transporter signature motif; other site 146891000769 Walker B; other site 146891000770 D-loop; other site 146891000771 H-loop/switch region; other site 146891000772 Smr domain; Region: Smr; pfam01713 146891000773 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 146891000774 GTP1/OBG; Region: GTP1_OBG; pfam01018 146891000775 Obg GTPase; Region: Obg; cd01898 146891000776 G1 box; other site 146891000777 GTP/Mg2+ binding site [chemical binding]; other site 146891000778 Switch I region; other site 146891000779 G2 box; other site 146891000780 G3 box; other site 146891000781 Switch II region; other site 146891000782 G4 box; other site 146891000783 CP12 domain; Region: CP12; pfam02672 146891000784 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 146891000785 putative dimer interface [polypeptide binding]; other site 146891000786 N-terminal domain interface [polypeptide binding]; other site 146891000787 putative substrate binding pocket (H-site) [chemical binding]; other site 146891000788 aspartoacylase; Provisional; Region: PRK02259 146891000789 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 146891000790 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 146891000791 protein I interface; other site 146891000792 D2 interface; other site 146891000793 protein T interface; other site 146891000794 chlorophyll binding site; other site 146891000795 beta carotene binding site; other site 146891000796 pheophytin binding site; other site 146891000797 manganese-stabilizing polypeptide interface; other site 146891000798 CP43 interface; other site 146891000799 protein L interface; other site 146891000800 oxygen evolving complex binding site; other site 146891000801 bromide binding site; other site 146891000802 quinone binding site; other site 146891000803 Fe binding site [ion binding]; other site 146891000804 core light harvesting interface; other site 146891000805 cytochrome b559 alpha subunit interface; other site 146891000806 cytochrome c-550 interface; other site 146891000807 protein J interface; other site 146891000808 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 146891000809 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 146891000810 Tetramer interface [polypeptide binding]; other site 146891000811 active site 146891000812 FMN-binding site [chemical binding]; other site 146891000813 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 146891000814 active site 146891000815 intersubunit interface [polypeptide binding]; other site 146891000816 catalytic residue [active] 146891000817 FtsH Extracellular; Region: FtsH_ext; pfam06480 146891000818 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 146891000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000820 Walker A motif; other site 146891000821 ATP binding site [chemical binding]; other site 146891000822 Walker B motif; other site 146891000823 arginine finger; other site 146891000824 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891000825 ATP sulphurylase; Region: sopT; TIGR00339 146891000826 ATP-sulfurylase; Region: ATPS; cd00517 146891000827 active site 146891000828 HXXH motif; other site 146891000829 flexible loop; other site 146891000830 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 146891000831 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 146891000832 Flavoprotein; Region: Flavoprotein; pfam02441 146891000833 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 146891000834 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 146891000835 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 146891000836 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 146891000837 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 146891000838 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 146891000839 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 146891000840 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891000841 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 146891000842 putative di-iron ligands [ion binding]; other site 146891000843 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 146891000844 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891000845 active site 146891000846 HIGH motif; other site 146891000847 nucleotide binding site [chemical binding]; other site 146891000848 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 146891000849 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 146891000850 active site 146891000851 KMSKS motif; other site 146891000852 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 146891000853 tRNA binding surface [nucleotide binding]; other site 146891000854 anticodon binding site; other site 146891000855 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 146891000856 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 146891000857 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 146891000858 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 146891000859 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 146891000860 active site 146891000861 substrate binding site [chemical binding]; other site 146891000862 metal binding site [ion binding]; metal-binding site 146891000863 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891000864 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 146891000865 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 146891000866 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 146891000867 trimer interface [polypeptide binding]; other site 146891000868 active site 146891000869 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 146891000870 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 146891000871 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 146891000872 ligand binding site [chemical binding]; other site 146891000873 flexible hinge region; other site 146891000874 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 146891000875 putative switch regulator; other site 146891000876 non-specific DNA interactions [nucleotide binding]; other site 146891000877 DNA binding site [nucleotide binding] 146891000878 sequence specific DNA binding site [nucleotide binding]; other site 146891000879 putative cAMP binding site [chemical binding]; other site 146891000880 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 146891000881 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 146891000882 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 146891000883 putative active site [active] 146891000884 catalytic residue [active] 146891000885 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 146891000886 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 146891000887 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 146891000888 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 146891000889 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 146891000890 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 146891000891 substrate binding site [chemical binding]; other site 146891000892 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 146891000893 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 146891000894 substrate binding site [chemical binding]; other site 146891000895 ligand binding site [chemical binding]; other site 146891000896 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 146891000897 competence damage-inducible protein A; Provisional; Region: PRK00549 146891000898 putative MPT binding site; other site 146891000899 Competence-damaged protein; Region: CinA; pfam02464 146891000900 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 146891000901 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 146891000902 dimer interface [polypeptide binding]; other site 146891000903 active site 146891000904 glycine-pyridoxal phosphate binding site [chemical binding]; other site 146891000905 folate binding site [chemical binding]; other site 146891000906 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 146891000907 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 146891000908 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 146891000909 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 146891000910 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 146891000911 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 146891000912 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 146891000913 DoxX; Region: DoxX; pfam07681 146891000914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 146891000915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 146891000916 purine monophosphate binding site [chemical binding]; other site 146891000917 dimer interface [polypeptide binding]; other site 146891000918 putative catalytic residues [active] 146891000919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 146891000920 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 146891000921 Predicted esterase [General function prediction only]; Region: COG0400 146891000922 Serine hydrolase (FSH1); Region: FSH1; pfam03959 146891000923 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 146891000924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 146891000925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891000926 dimer interface [polypeptide binding]; other site 146891000927 phosphorylation site [posttranslational modification] 146891000928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891000929 ATP binding site [chemical binding]; other site 146891000930 Mg2+ binding site [ion binding]; other site 146891000931 G-X-G motif; other site 146891000932 cobalamin synthase; Reviewed; Region: cobS; PRK00235 146891000933 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 146891000934 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 146891000935 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 146891000936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891000937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 146891000938 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 146891000939 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 146891000940 Domain of unknown function DUF21; Region: DUF21; pfam01595 146891000941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 146891000942 Transporter associated domain; Region: CorC_HlyC; smart01091 146891000943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891000944 active site 146891000945 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 146891000946 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 146891000947 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 146891000948 Uncharacterized conserved protein [Function unknown]; Region: COG3743 146891000949 RNase_H superfamily; Region: RNase_H_2; pfam13482 146891000950 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 146891000951 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 146891000952 active site 146891000953 substrate binding site [chemical binding]; other site 146891000954 metal binding site [ion binding]; metal-binding site 146891000955 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 146891000956 active site 146891000957 dimerization interface [polypeptide binding]; other site 146891000958 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 146891000959 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 146891000960 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 146891000961 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 146891000962 putative active site pocket [active] 146891000963 4-fold oligomerization interface [polypeptide binding]; other site 146891000964 metal binding residues [ion binding]; metal-binding site 146891000965 3-fold/trimer interface [polypeptide binding]; other site 146891000966 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 146891000967 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 146891000968 NAD binding site [chemical binding]; other site 146891000969 homotetramer interface [polypeptide binding]; other site 146891000970 homodimer interface [polypeptide binding]; other site 146891000971 substrate binding site [chemical binding]; other site 146891000972 active site 146891000973 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 146891000974 putative catalytic residue [active] 146891000975 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 146891000976 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 146891000977 inhibitor-cofactor binding pocket; inhibition site 146891000978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000979 catalytic residue [active] 146891000980 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 146891000981 DNA photolyase; Region: DNA_photolyase; pfam00875 146891000982 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 146891000983 dimer interface [polypeptide binding]; other site 146891000984 ADP-ribose binding site [chemical binding]; other site 146891000985 active site 146891000986 nudix motif; other site 146891000987 metal binding site [ion binding]; metal-binding site 146891000988 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 146891000989 catalytic center binding site [active] 146891000990 ATP binding site [chemical binding]; other site 146891000991 Protein of unknown function (DUF444); Region: DUF444; cl17371 146891000992 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 146891000993 metal ion-dependent adhesion site (MIDAS); other site 146891000994 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 146891000995 mce related protein; Region: MCE; pfam02470 146891000996 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891000997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891000998 Walker A/P-loop; other site 146891000999 ATP binding site [chemical binding]; other site 146891001000 Q-loop/lid; other site 146891001001 ABC transporter signature motif; other site 146891001002 Walker B; other site 146891001003 D-loop; other site 146891001004 H-loop/switch region; other site 146891001005 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 146891001006 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 146891001007 phosphate binding site [ion binding]; other site 146891001008 putative substrate binding pocket [chemical binding]; other site 146891001009 dimer interface [polypeptide binding]; other site 146891001010 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 146891001011 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 146891001012 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 146891001013 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 146891001014 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 146891001015 Rubredoxin; Region: Rubredoxin; pfam00301 146891001016 iron binding site [ion binding]; other site 146891001017 Ycf48-like protein; Provisional; Region: PRK13684 146891001018 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 146891001019 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 146891001020 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 146891001021 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 146891001022 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 146891001023 photosystem II reaction center protein J; Provisional; Region: PRK02565 146891001024 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 146891001025 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 146891001026 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 146891001027 selenium donor protein; Region: selD; TIGR00476 146891001028 dimerization interface [polypeptide binding]; other site 146891001029 ATP binding site [chemical binding]; other site 146891001030 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 146891001031 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 146891001032 active site 146891001033 NTP binding site [chemical binding]; other site 146891001034 metal binding triad [ion binding]; metal-binding site 146891001035 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 146891001036 Part of AAA domain; Region: AAA_19; pfam13245 146891001037 Family description; Region: UvrD_C_2; pfam13538 146891001038 Phycobilisome protein; Region: Phycobilisome; cl08227 146891001039 CpeS-like protein; Region: CpeS; pfam09367 146891001040 D-xylulose kinase; Region: XylB; TIGR01312 146891001041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 146891001042 nucleotide binding site [chemical binding]; other site 146891001043 S-adenosylmethionine synthetase; Validated; Region: PRK05250 146891001044 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 146891001045 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 146891001046 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 146891001047 30S ribosomal protein S1; Reviewed; Region: PRK07400 146891001048 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 146891001049 RNA binding site [nucleotide binding]; other site 146891001050 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 146891001051 RNA binding site [nucleotide binding]; other site 146891001052 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 146891001053 RNA binding site [nucleotide binding]; other site 146891001054 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 146891001055 ATP cone domain; Region: ATP-cone; pfam03477 146891001056 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 146891001057 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 146891001058 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 146891001059 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891001060 catalytic loop [active] 146891001061 iron binding site [ion binding]; other site 146891001062 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 146891001063 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 146891001064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001065 S-adenosylmethionine binding site [chemical binding]; other site 146891001066 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 146891001067 cell division topological specificity factor MinE; Provisional; Region: PRK13988 146891001068 septum site-determining protein MinD; Region: minD_bact; TIGR01968 146891001069 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 146891001070 P-loop; other site 146891001071 ADP binding residues [chemical binding]; other site 146891001072 Switch I; other site 146891001073 Switch II; other site 146891001074 septum formation inhibitor; Reviewed; Region: minC; PRK00513 146891001075 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 146891001076 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 146891001077 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 146891001078 Zn2+ binding site [ion binding]; other site 146891001079 Mg2+ binding site [ion binding]; other site 146891001080 carboxyl-terminal processing protease; Provisional; Region: PLN00049 146891001081 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 146891001082 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 146891001083 protein binding site [polypeptide binding]; other site 146891001084 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 146891001085 Catalytic dyad [active] 146891001086 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 146891001087 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 146891001088 Qi binding site; other site 146891001089 intrachain domain interface; other site 146891001090 interchain domain interface [polypeptide binding]; other site 146891001091 heme bH binding site [chemical binding]; other site 146891001092 heme bL binding site [chemical binding]; other site 146891001093 Qo binding site; other site 146891001094 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 146891001095 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 146891001096 interchain domain interface [polypeptide binding]; other site 146891001097 intrachain domain interface; other site 146891001098 Qi binding site; other site 146891001099 Qo binding site; other site 146891001100 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 146891001101 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 146891001102 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 146891001103 DNA binding site [nucleotide binding] 146891001104 catalytic residue [active] 146891001105 H2TH interface [polypeptide binding]; other site 146891001106 putative catalytic residues [active] 146891001107 turnover-facilitating residue; other site 146891001108 intercalation triad [nucleotide binding]; other site 146891001109 8OG recognition residue [nucleotide binding]; other site 146891001110 putative reading head residues; other site 146891001111 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 146891001112 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 146891001113 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 146891001114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 146891001115 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 146891001116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 146891001117 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 146891001118 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 146891001119 NAD(P) binding site [chemical binding]; other site 146891001120 catalytic residues [active] 146891001121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891001122 Coenzyme A binding pocket [chemical binding]; other site 146891001123 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 146891001124 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 146891001125 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 146891001126 dinuclear metal binding motif [ion binding]; other site 146891001127 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 146891001128 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 146891001129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891001130 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 146891001131 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 146891001132 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 146891001133 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 146891001134 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891001135 catalytic triad [active] 146891001136 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 146891001137 hypothetical protein; Provisional; Region: PRK09256 146891001138 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891001139 CAAX protease self-immunity; Region: Abi; pfam02517 146891001140 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 146891001141 GDP-Fucose binding site [chemical binding]; other site 146891001142 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 146891001143 active site 146891001144 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 146891001145 TAP-like protein; Region: Abhydrolase_4; pfam08386 146891001146 DNA photolyase; Region: DNA_photolyase; pfam00875 146891001147 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891001148 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 146891001149 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 146891001150 substrate binding site [chemical binding]; other site 146891001151 dimer interface [polypeptide binding]; other site 146891001152 ATP binding site [chemical binding]; other site 146891001153 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 146891001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 146891001155 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891001156 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 146891001157 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 146891001158 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 146891001159 putative NAD(P) binding site [chemical binding]; other site 146891001160 active site 146891001161 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 146891001162 putative high light inducible protein; Region: PHA02337 146891001163 putative high light inducible protein; Region: PHA02337 146891001164 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 146891001165 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 146891001166 additional DNA contacts [nucleotide binding]; other site 146891001167 mismatch recognition site; other site 146891001168 active site 146891001169 zinc binding site [ion binding]; other site 146891001170 DNA intercalation site [nucleotide binding]; other site 146891001171 Z1 domain; Region: Z1; pfam10593 146891001172 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 146891001173 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 146891001174 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 146891001175 cofactor binding site; other site 146891001176 DNA binding site [nucleotide binding] 146891001177 substrate interaction site [chemical binding]; other site 146891001178 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 146891001179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 146891001180 active site 146891001181 DNA binding site [nucleotide binding] 146891001182 Int/Topo IB signature motif; other site 146891001183 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 146891001184 Dehydroquinase class II; Region: DHquinase_II; pfam01220 146891001185 active site 146891001186 trimer interface [polypeptide binding]; other site 146891001187 dimer interface [polypeptide binding]; other site 146891001188 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 146891001189 active site 146891001190 dinuclear metal binding site [ion binding]; other site 146891001191 dimerization interface [polypeptide binding]; other site 146891001192 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 146891001193 active site 146891001194 SAM binding site [chemical binding]; other site 146891001195 homodimer interface [polypeptide binding]; other site 146891001196 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 146891001197 GTP-binding protein Der; Reviewed; Region: PRK00093 146891001198 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 146891001199 G1 box; other site 146891001200 GTP/Mg2+ binding site [chemical binding]; other site 146891001201 Switch I region; other site 146891001202 G2 box; other site 146891001203 Switch II region; other site 146891001204 G3 box; other site 146891001205 G4 box; other site 146891001206 G5 box; other site 146891001207 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 146891001208 G1 box; other site 146891001209 GTP/Mg2+ binding site [chemical binding]; other site 146891001210 Switch I region; other site 146891001211 G2 box; other site 146891001212 G3 box; other site 146891001213 Switch II region; other site 146891001214 G4 box; other site 146891001215 G5 box; other site 146891001216 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 146891001217 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 146891001218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 146891001219 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891001220 catalytic residue [active] 146891001221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 146891001222 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 146891001223 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 146891001224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 146891001225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891001226 Recombination protein O N terminal; Region: RecO_N; pfam11967 146891001227 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 146891001228 Recombination protein O C terminal; Region: RecO_C; pfam02565 146891001229 Class I aldolases; Region: Aldolase_Class_I; cl17187 146891001230 catalytic residue [active] 146891001231 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 146891001232 30S subunit binding site; other site 146891001233 lipoate-protein ligase B; Provisional; Region: PRK14344 146891001234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 146891001235 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 146891001236 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 146891001237 acyl-activating enzyme (AAE) consensus motif; other site 146891001238 acyl-activating enzyme (AAE) consensus motif; other site 146891001239 putative AMP binding site [chemical binding]; other site 146891001240 putative active site [active] 146891001241 putative CoA binding site [chemical binding]; other site 146891001242 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 146891001243 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 146891001244 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 146891001245 E3 interaction surface; other site 146891001246 lipoyl attachment site [posttranslational modification]; other site 146891001247 e3 binding domain; Region: E3_binding; pfam02817 146891001248 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 146891001249 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 146891001250 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 146891001251 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 146891001252 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 146891001253 dimer interface [polypeptide binding]; other site 146891001254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001255 catalytic residue [active] 146891001256 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891001257 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 146891001258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891001259 catalytic residue [active] 146891001260 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 146891001261 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 146891001262 homodimer interface [polypeptide binding]; other site 146891001263 substrate-cofactor binding pocket; other site 146891001264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001265 catalytic residue [active] 146891001266 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 146891001267 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 146891001268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891001269 RNA binding surface [nucleotide binding]; other site 146891001270 hypothetical protein; Provisional; Region: PRK14390 146891001271 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 146891001272 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 146891001273 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891001274 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 146891001275 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 146891001276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001277 C factor cell-cell signaling protein; Provisional; Region: PRK09009 146891001278 NAD(P) binding site [chemical binding]; other site 146891001279 active site 146891001280 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 146891001281 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891001282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891001283 catalytic residue [active] 146891001284 Methyltransferase domain; Region: Methyltransf_31; pfam13847 146891001285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001286 S-adenosylmethionine binding site [chemical binding]; other site 146891001287 NifU-like domain; Region: NifU; pfam01106 146891001288 malate:quinone oxidoreductase; Validated; Region: PRK05257 146891001289 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 146891001290 GTP-binding protein LepA; Provisional; Region: PRK05433 146891001291 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 146891001292 G1 box; other site 146891001293 putative GEF interaction site [polypeptide binding]; other site 146891001294 GTP/Mg2+ binding site [chemical binding]; other site 146891001295 Switch I region; other site 146891001296 G2 box; other site 146891001297 G3 box; other site 146891001298 Switch II region; other site 146891001299 G4 box; other site 146891001300 G5 box; other site 146891001301 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 146891001302 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 146891001303 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 146891001304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 146891001305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001306 dimer interface [polypeptide binding]; other site 146891001307 conserved gate region; other site 146891001308 ABC-ATPase subunit interface; other site 146891001309 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 146891001310 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 146891001311 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 146891001312 Protein of unknown function, DUF393; Region: DUF393; pfam04134 146891001313 TIGR03643 family protein; Region: TIGR03643 146891001314 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 146891001315 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 146891001316 16S rRNA methyltransferase B; Provisional; Region: PRK14901 146891001317 NusB family; Region: NusB; pfam01029 146891001318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001319 S-adenosylmethionine binding site [chemical binding]; other site 146891001320 Transglycosylase; Region: Transgly; pfam00912 146891001321 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 146891001322 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 146891001323 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 146891001324 UbiA prenyltransferase family; Region: UbiA; pfam01040 146891001325 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 146891001326 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 146891001327 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 146891001328 substrate binding site [chemical binding]; other site 146891001329 glutamase interaction surface [polypeptide binding]; other site 146891001330 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 146891001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001332 S-adenosylmethionine binding site [chemical binding]; other site 146891001333 Protein of unknown function (DUF721); Region: DUF721; pfam05258 146891001334 Protein of unknown function (DUF721); Region: DUF721; cl02324 146891001335 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 146891001336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 146891001337 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 146891001338 Walker A/P-loop; other site 146891001339 ATP binding site [chemical binding]; other site 146891001340 Q-loop/lid; other site 146891001341 ABC transporter signature motif; other site 146891001342 Walker B; other site 146891001343 D-loop; other site 146891001344 H-loop/switch region; other site 146891001345 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 146891001346 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 146891001347 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 146891001348 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 146891001349 active site 146891001350 interdomain interaction site; other site 146891001351 putative metal-binding site [ion binding]; other site 146891001352 nucleotide binding site [chemical binding]; other site 146891001353 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 146891001354 domain I; other site 146891001355 phosphate binding site [ion binding]; other site 146891001356 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 146891001357 domain II; other site 146891001358 domain III; other site 146891001359 nucleotide binding site [chemical binding]; other site 146891001360 DNA binding groove [nucleotide binding] 146891001361 catalytic site [active] 146891001362 domain IV; other site 146891001363 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 146891001364 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 146891001365 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 146891001366 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 146891001367 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 146891001368 active site pocket [active] 146891001369 putative dimer interface [polypeptide binding]; other site 146891001370 putative cataytic base [active] 146891001371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 146891001372 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 146891001373 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 146891001374 active site 146891001375 catalytic tetrad [active] 146891001376 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 146891001377 Lumazine binding domain; Region: Lum_binding; pfam00677 146891001378 Lumazine binding domain; Region: Lum_binding; pfam00677 146891001379 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 146891001380 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 146891001381 Subunit I/III interface [polypeptide binding]; other site 146891001382 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 146891001383 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 146891001384 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 146891001385 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 146891001386 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 146891001387 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 146891001388 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 146891001389 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 146891001390 UbiA prenyltransferase family; Region: UbiA; pfam01040 146891001391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 146891001392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891001393 Walker A/P-loop; other site 146891001394 ATP binding site [chemical binding]; other site 146891001395 Q-loop/lid; other site 146891001396 ABC transporter signature motif; other site 146891001397 Walker B; other site 146891001398 D-loop; other site 146891001399 H-loop/switch region; other site 146891001400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 146891001401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 146891001402 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 146891001403 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 146891001404 ring oligomerisation interface [polypeptide binding]; other site 146891001405 ATP/Mg binding site [chemical binding]; other site 146891001406 stacking interactions; other site 146891001407 hinge regions; other site 146891001408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 146891001409 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 146891001410 NAD(P) binding site [chemical binding]; other site 146891001411 homotetramer interface [polypeptide binding]; other site 146891001412 homodimer interface [polypeptide binding]; other site 146891001413 active site 146891001414 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 146891001415 substrate binding site; other site 146891001416 dimer interface; other site 146891001417 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 146891001418 dimer interface [polypeptide binding]; other site 146891001419 catalytic triad [active] 146891001420 prenyltransferase; Reviewed; Region: ubiA; PRK12873 146891001421 UbiA prenyltransferase family; Region: UbiA; pfam01040 146891001422 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 146891001423 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 146891001424 Helix-turn-helix domain; Region: HTH_25; pfam13413 146891001425 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 146891001426 active site 146891001427 SAM binding site [chemical binding]; other site 146891001428 homodimer interface [polypeptide binding]; other site 146891001429 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 146891001430 cytochrome f; Region: petA; CHL00037 146891001431 apocytochrome f; Reviewed; Region: PRK02693 146891001432 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 146891001433 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 146891001434 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 146891001435 cytochrome b subunit interaction site [polypeptide binding]; other site 146891001436 [2Fe-2S] cluster binding site [ion binding]; other site 146891001437 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 146891001438 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 146891001439 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 146891001440 Domain of unknown function (DUF814); Region: DUF814; pfam05670 146891001441 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 146891001442 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 146891001443 catalytic site [active] 146891001444 G-X2-G-X-G-K; other site 146891001445 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 146891001446 UGMP family protein; Validated; Region: PRK09604 146891001447 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 146891001448 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 146891001449 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 146891001450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891001451 active site 146891001452 HIGH motif; other site 146891001453 nucleotide binding site [chemical binding]; other site 146891001454 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 146891001455 active site 146891001456 KMSKS motif; other site 146891001457 Src Homology 3 domain superfamily; Region: SH3; cl17036 146891001458 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 146891001459 methionine aminopeptidase; Provisional; Region: PRK08671 146891001460 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 146891001461 active site 146891001462 short chain dehydrogenase; Provisional; Region: PRK12367 146891001463 NAD(P) binding site [chemical binding]; other site 146891001464 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 146891001465 DRTGG domain; Region: DRTGG; pfam07085 146891001466 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 146891001467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 146891001468 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 146891001469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 146891001470 SPFH domain / Band 7 family; Region: Band_7; pfam01145 146891001471 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 146891001472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891001473 inhibitor-cofactor binding pocket; inhibition site 146891001474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001475 catalytic residue [active] 146891001476 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 146891001477 putative catalytic site [active] 146891001478 putative phosphate binding site [ion binding]; other site 146891001479 active site 146891001480 metal binding site A [ion binding]; metal-binding site 146891001481 DNA binding site [nucleotide binding] 146891001482 putative AP binding site [nucleotide binding]; other site 146891001483 putative metal binding site B [ion binding]; other site 146891001484 hypothetical protein; Provisional; Region: PRK04194 146891001485 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 146891001486 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 146891001487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001488 dimer interface [polypeptide binding]; other site 146891001489 conserved gate region; other site 146891001490 putative PBP binding loops; other site 146891001491 ABC-ATPase subunit interface; other site 146891001492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001493 dimer interface [polypeptide binding]; other site 146891001494 conserved gate region; other site 146891001495 putative PBP binding loops; other site 146891001496 ABC-ATPase subunit interface; other site 146891001497 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 146891001498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891001499 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 146891001500 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 146891001501 aromatic arch; other site 146891001502 DCoH dimer interaction site [polypeptide binding]; other site 146891001503 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 146891001504 DCoH tetramer interaction site [polypeptide binding]; other site 146891001505 substrate binding site [chemical binding]; other site 146891001506 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 146891001507 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 146891001508 dimer interface [polypeptide binding]; other site 146891001509 substrate binding site [chemical binding]; other site 146891001510 metal binding sites [ion binding]; metal-binding site 146891001511 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 146891001512 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 146891001513 domain interfaces; other site 146891001514 active site 146891001515 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891001516 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891001517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891001518 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891001519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891001520 DNA binding residues [nucleotide binding] 146891001521 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 146891001522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891001523 ATP binding site [chemical binding]; other site 146891001524 putative Mg++ binding site [ion binding]; other site 146891001525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891001526 ATP-binding site [chemical binding]; other site 146891001527 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 146891001528 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 146891001529 feedback inhibition sensing region; other site 146891001530 homohexameric interface [polypeptide binding]; other site 146891001531 nucleotide binding site [chemical binding]; other site 146891001532 N-acetyl-L-glutamate binding site [chemical binding]; other site 146891001533 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 146891001534 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 146891001535 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 146891001536 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 146891001537 ssDNA binding site [nucleotide binding]; other site 146891001538 dimer interface [polypeptide binding]; other site 146891001539 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891001540 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 146891001541 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 146891001542 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 146891001543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891001544 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 146891001545 substrate binding site [chemical binding]; other site 146891001546 ATP binding site [chemical binding]; other site 146891001547 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 146891001548 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 146891001549 GDP-binding site [chemical binding]; other site 146891001550 ACT binding site; other site 146891001551 IMP binding site; other site 146891001552 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 146891001553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 146891001554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 146891001555 dimer interface [polypeptide binding]; other site 146891001556 motif 1; other site 146891001557 active site 146891001558 motif 2; other site 146891001559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 146891001560 putative deacylase active site [active] 146891001561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 146891001562 motif 3; other site 146891001563 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 146891001564 anticodon binding site; other site 146891001565 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 146891001566 dimer interface [polypeptide binding]; other site 146891001567 substrate binding site [chemical binding]; other site 146891001568 metal binding sites [ion binding]; metal-binding site 146891001569 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 146891001570 ArsC family; Region: ArsC; pfam03960 146891001571 putative ArsC-like catalytic residues; other site 146891001572 putative TRX-like catalytic residues [active] 146891001573 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 146891001574 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891001575 Catalytic site [active] 146891001576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 146891001577 catalytic core [active] 146891001578 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 146891001579 catalytic core [active] 146891001580 CAAX protease self-immunity; Region: Abi; pfam02517 146891001581 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 146891001582 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 146891001583 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 146891001584 transaldolase-like protein; Provisional; Region: PTZ00411 146891001585 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 146891001586 active site 146891001587 dimer interface [polypeptide binding]; other site 146891001588 catalytic residue [active] 146891001589 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 146891001590 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 146891001591 ribosome recycling factor; Reviewed; Region: frr; PRK00083 146891001592 hinge region; other site 146891001593 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 146891001594 putative nucleotide binding site [chemical binding]; other site 146891001595 uridine monophosphate binding site [chemical binding]; other site 146891001596 homohexameric interface [polypeptide binding]; other site 146891001597 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 146891001598 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 146891001599 homodimer interface [polypeptide binding]; other site 146891001600 Walker A motif; other site 146891001601 ATP binding site [chemical binding]; other site 146891001602 hydroxycobalamin binding site [chemical binding]; other site 146891001603 Walker B motif; other site 146891001604 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 146891001605 active site 146891001606 catalytic residues [active] 146891001607 DNA binding site [nucleotide binding] 146891001608 Int/Topo IB signature motif; other site 146891001609 ferrochelatase; Reviewed; Region: hemH; PRK00035 146891001610 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 146891001611 C-terminal domain interface [polypeptide binding]; other site 146891001612 active site 146891001613 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 146891001614 active site 146891001615 N-terminal domain interface [polypeptide binding]; other site 146891001616 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 146891001617 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 146891001618 PYR/PP interface [polypeptide binding]; other site 146891001619 dimer interface [polypeptide binding]; other site 146891001620 TPP binding site [chemical binding]; other site 146891001621 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 146891001622 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 146891001623 TPP-binding site [chemical binding]; other site 146891001624 dimer interface [polypeptide binding]; other site 146891001625 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 146891001626 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 146891001627 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 146891001628 RNA binding site [nucleotide binding]; other site 146891001629 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 146891001630 RNA binding site [nucleotide binding]; other site 146891001631 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 146891001632 RNA binding site [nucleotide binding]; other site 146891001633 Creatinine amidohydrolase; Region: Creatininase; pfam02633 146891001634 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 146891001635 dinuclear metal binding motif [ion binding]; other site 146891001636 acyl-ACP reductase; Provisional; Region: PRK14982 146891001637 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 146891001638 NAD(P) binding pocket [chemical binding]; other site 146891001639 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 146891001640 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 146891001641 short chain dehydrogenase; Provisional; Region: PRK07454 146891001642 classical (c) SDRs; Region: SDR_c; cd05233 146891001643 NAD(P) binding site [chemical binding]; other site 146891001644 active site 146891001645 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891001646 GTP cyclohydrolase I; Provisional; Region: PLN03044 146891001647 active site 146891001648 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 146891001649 active site 146891001650 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 146891001651 active site 146891001652 putative substrate binding region [chemical binding]; other site 146891001653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 146891001654 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 146891001655 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 146891001656 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 146891001657 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 146891001658 NAD(P) binding site [chemical binding]; other site 146891001659 active site 146891001660 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 146891001661 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 146891001662 P-loop; other site 146891001663 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 146891001664 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 146891001665 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 146891001666 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 146891001667 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 146891001668 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 146891001669 putative hexamer interface [polypeptide binding]; other site 146891001670 putative hexagonal pore; other site 146891001671 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 146891001672 putative hexamer interface [polypeptide binding]; other site 146891001673 putative hexagonal pore; other site 146891001674 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 146891001675 active site 146891001676 dimerization interface [polypeptide binding]; other site 146891001677 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 146891001678 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 146891001679 Hexamer interface [polypeptide binding]; other site 146891001680 Hexagonal pore residue; other site 146891001681 Hexagonal pore; other site 146891001682 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 146891001683 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 146891001684 dimer interface [polypeptide binding]; other site 146891001685 catalytic residue [active] 146891001686 metal binding site [ion binding]; metal-binding site 146891001687 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 146891001688 multimerization interface [polypeptide binding]; other site 146891001689 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 146891001690 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 146891001691 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 146891001692 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 146891001693 Hexamer/Pentamer interface [polypeptide binding]; other site 146891001694 central pore; other site 146891001695 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 146891001696 Hexamer/Pentamer interface [polypeptide binding]; other site 146891001697 central pore; other site 146891001698 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 146891001699 DCoH dimer interaction site [polypeptide binding]; other site 146891001700 aromatic arch; other site 146891001701 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 146891001702 DCoH tetramer interaction site [polypeptide binding]; other site 146891001703 substrate binding site [chemical binding]; other site 146891001704 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 146891001705 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 146891001706 homotrimer interaction site [polypeptide binding]; other site 146891001707 putative active site [active] 146891001708 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 146891001709 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 146891001710 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 146891001711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891001712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 146891001713 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 146891001714 Walker A/P-loop; other site 146891001715 ATP binding site [chemical binding]; other site 146891001716 Q-loop/lid; other site 146891001717 ABC transporter signature motif; other site 146891001718 Walker B; other site 146891001719 D-loop; other site 146891001720 H-loop/switch region; other site 146891001721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 146891001722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891001723 Coenzyme A binding pocket [chemical binding]; other site 146891001724 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 146891001725 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 146891001726 Probable Catalytic site; other site 146891001727 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 146891001728 DnaA N-terminal domain; Region: DnaA_N; pfam11638 146891001729 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 146891001730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001731 Walker A motif; other site 146891001732 ATP binding site [chemical binding]; other site 146891001733 Walker B motif; other site 146891001734 arginine finger; other site 146891001735 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 146891001736 DnaA box-binding interface [nucleotide binding]; other site 146891001737 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 146891001738 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 146891001739 C-terminal domain interface [polypeptide binding]; other site 146891001740 GSH binding site (G-site) [chemical binding]; other site 146891001741 dimer interface [polypeptide binding]; other site 146891001742 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 146891001743 glutathione reductase; Validated; Region: PRK06116 146891001744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 146891001745 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 146891001746 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 146891001747 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 146891001748 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 146891001749 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 146891001750 active site 146891001751 substrate binding pocket [chemical binding]; other site 146891001752 dimer interface [polypeptide binding]; other site 146891001753 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 146891001754 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 146891001755 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 146891001756 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 146891001757 substrate binding site [chemical binding]; other site 146891001758 active site 146891001759 catalytic residues [active] 146891001760 heterodimer interface [polypeptide binding]; other site 146891001761 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 146891001762 YciI-like protein; Reviewed; Region: PRK12864 146891001763 Uncharacterized conserved protein [Function unknown]; Region: COG3339 146891001764 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891001765 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891001766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891001767 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891001768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891001769 DNA binding residues [nucleotide binding] 146891001770 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 146891001771 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 146891001772 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 146891001773 metal binding site [ion binding]; metal-binding site 146891001774 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 146891001775 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 146891001776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001777 Walker A motif; other site 146891001778 ATP binding site [chemical binding]; other site 146891001779 Walker B motif; other site 146891001780 arginine finger; other site 146891001781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001782 Walker A motif; other site 146891001783 ATP binding site [chemical binding]; other site 146891001784 Walker B motif; other site 146891001785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 146891001786 plastocyanin; Provisional; Region: PRK02710 146891001787 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 146891001788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001789 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891001790 NAD(P) binding site [chemical binding]; other site 146891001791 active site 146891001792 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 146891001793 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 146891001794 substrate binding site [chemical binding]; other site 146891001795 active site 146891001796 glycogen branching enzyme; Provisional; Region: PRK05402 146891001797 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 146891001798 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 146891001799 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 146891001800 active site 146891001801 catalytic site [active] 146891001802 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 146891001803 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 146891001804 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 146891001805 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 146891001806 Protein of function (DUF2518); Region: DUF2518; pfam10726 146891001807 Family of unknown function (DUF490); Region: DUF490; pfam04357 146891001808 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 146891001809 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 146891001810 putative catalytic cysteine [active] 146891001811 Dihydroneopterin aldolase; Region: FolB; smart00905 146891001812 active site 146891001813 Lipase (class 2); Region: Lipase_2; pfam01674 146891001814 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 146891001815 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 146891001816 active site 146891001817 Zn binding site [ion binding]; other site 146891001818 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 146891001819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 146891001820 homoserine kinase; Provisional; Region: PRK01212 146891001821 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 146891001822 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 146891001823 glucokinase, proteobacterial type; Region: glk; TIGR00749 146891001824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 146891001825 nucleotide binding site [chemical binding]; other site 146891001826 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 146891001827 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 146891001828 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 146891001829 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 146891001830 active site 146891001831 dimer interface [polypeptide binding]; other site 146891001832 motif 1; other site 146891001833 motif 2; other site 146891001834 motif 3; other site 146891001835 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 146891001836 anticodon binding site; other site 146891001837 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 146891001838 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 146891001839 active site 146891001840 HIGH motif; other site 146891001841 dimer interface [polypeptide binding]; other site 146891001842 KMSKS motif; other site 146891001843 Domain of unknown function (DUF697); Region: DUF697; pfam05128 146891001844 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 146891001845 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 146891001846 metal binding site [ion binding]; metal-binding site 146891001847 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 146891001848 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 146891001849 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 146891001850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 146891001851 ABC-ATPase subunit interface; other site 146891001852 dimer interface [polypeptide binding]; other site 146891001853 putative PBP binding regions; other site 146891001854 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 146891001855 Protein of unknown function (DUF760); Region: DUF760; pfam05542 146891001856 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 146891001857 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891001858 Catalytic site [active] 146891001859 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 146891001860 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 146891001861 dimer interface [polypeptide binding]; other site 146891001862 tetramer interface [polypeptide binding]; other site 146891001863 PYR/PP interface [polypeptide binding]; other site 146891001864 TPP binding site [chemical binding]; other site 146891001865 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 146891001866 TPP-binding site; other site 146891001867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 146891001868 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 146891001869 substrate binding site [chemical binding]; other site 146891001870 oxyanion hole (OAH) forming residues; other site 146891001871 trimer interface [polypeptide binding]; other site 146891001872 glycogen synthase; Provisional; Region: glgA; PRK00654 146891001873 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 146891001874 ADP-binding pocket [chemical binding]; other site 146891001875 homodimer interface [polypeptide binding]; other site 146891001876 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891001877 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 146891001878 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 146891001879 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 146891001880 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 146891001881 Substrate binding site; other site 146891001882 Mg++ binding site; other site 146891001883 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 146891001884 active site 146891001885 substrate binding site [chemical binding]; other site 146891001886 CoA binding site [chemical binding]; other site 146891001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001888 S-adenosylmethionine binding site [chemical binding]; other site 146891001889 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 146891001890 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 146891001891 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 146891001892 hinge; other site 146891001893 active site 146891001894 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 146891001895 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 146891001896 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 146891001897 nitrilase; Region: PLN02798 146891001898 putative active site [active] 146891001899 catalytic triad [active] 146891001900 dimer interface [polypeptide binding]; other site 146891001901 AMIN domain; Region: AMIN; pfam11741 146891001902 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 146891001903 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 146891001904 active site 146891001905 metal binding site [ion binding]; metal-binding site 146891001906 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 146891001907 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 146891001908 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 146891001909 substrate binding pocket [chemical binding]; other site 146891001910 chain length determination region; other site 146891001911 substrate-Mg2+ binding site; other site 146891001912 catalytic residues [active] 146891001913 aspartate-rich region 1; other site 146891001914 active site lid residues [active] 146891001915 aspartate-rich region 2; other site 146891001916 acetyl-CoA synthetase; Provisional; Region: PRK00174 146891001917 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 146891001918 active site 146891001919 CoA binding site [chemical binding]; other site 146891001920 acyl-activating enzyme (AAE) consensus motif; other site 146891001921 AMP binding site [chemical binding]; other site 146891001922 acetate binding site [chemical binding]; other site 146891001923 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 146891001924 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 146891001925 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 146891001926 active site 146891001927 catalytic site [active] 146891001928 substrate binding site [chemical binding]; other site 146891001929 GLTT repeat (6 copies); Region: GLTT; pfam01744 146891001930 GLTT repeat (6 copies); Region: GLTT; pfam01744 146891001931 Protein of unknown function; Region: DUF3721; pfam12518 146891001932 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 146891001933 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 146891001934 dimer interface [polypeptide binding]; other site 146891001935 motif 1; other site 146891001936 active site 146891001937 motif 2; other site 146891001938 motif 3; other site 146891001939 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 146891001940 anticodon binding site; other site 146891001941 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 146891001942 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 146891001943 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 146891001944 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891001945 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 146891001946 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 146891001947 putative N-terminal domain interface [polypeptide binding]; other site 146891001948 putative dimer interface [polypeptide binding]; other site 146891001949 putative substrate binding pocket (H-site) [chemical binding]; other site 146891001950 T5orf172 domain; Region: T5orf172; pfam10544 146891001951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001952 short chain dehydrogenase; Provisional; Region: PRK07326 146891001953 NAD(P) binding site [chemical binding]; other site 146891001954 active site 146891001955 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 146891001956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001957 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 146891001958 NAD(P) binding site [chemical binding]; other site 146891001959 active site 146891001960 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 146891001961 Mechanosensitive ion channel; Region: MS_channel; pfam00924 146891001962 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 146891001963 Isochorismatase family; Region: Isochorismatase; pfam00857 146891001964 catalytic triad [active] 146891001965 dimer interface [polypeptide binding]; other site 146891001966 conserved cis-peptide bond; other site 146891001967 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 146891001968 metal binding site 2 [ion binding]; metal-binding site 146891001969 putative DNA binding helix; other site 146891001970 metal binding site 1 [ion binding]; metal-binding site 146891001971 dimer interface [polypeptide binding]; other site 146891001972 structural Zn2+ binding site [ion binding]; other site 146891001973 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 146891001974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891001975 FeS/SAM binding site; other site 146891001976 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 146891001977 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 146891001978 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 146891001979 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 146891001980 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 146891001981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 146891001982 homodimer interface [polypeptide binding]; other site 146891001983 substrate-cofactor binding pocket; other site 146891001984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001985 catalytic residue [active] 146891001986 Homoserine O-succinyltransferase; Region: HTS; pfam04204 146891001987 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 146891001988 conserved cys residue [active] 146891001989 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 146891001990 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 146891001991 Sulfate transporter family; Region: Sulfate_transp; pfam00916 146891001992 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 146891001993 FAD binding domain; Region: FAD_binding_4; pfam01565 146891001994 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 146891001995 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 146891001996 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 146891001997 putative active site [active] 146891001998 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 146891001999 putative active site [active] 146891002000 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 146891002001 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 146891002002 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 146891002003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002004 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 146891002005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 146891002007 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 146891002008 dimer interface [polypeptide binding]; other site 146891002009 active site 146891002010 metal binding site [ion binding]; metal-binding site 146891002011 glutathione binding site [chemical binding]; other site 146891002012 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 146891002013 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 146891002014 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 146891002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891002016 S-adenosylmethionine binding site [chemical binding]; other site 146891002017 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 146891002018 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 146891002019 G1 box; other site 146891002020 putative GEF interaction site [polypeptide binding]; other site 146891002021 GTP/Mg2+ binding site [chemical binding]; other site 146891002022 Switch I region; other site 146891002023 G2 box; other site 146891002024 G3 box; other site 146891002025 Switch II region; other site 146891002026 G4 box; other site 146891002027 G5 box; other site 146891002028 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 146891002029 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 146891002030 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 146891002031 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 146891002032 dimerization interface [polypeptide binding]; other site 146891002033 domain crossover interface; other site 146891002034 redox-dependent activation switch; other site 146891002035 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891002036 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 146891002037 Walker A/P-loop; other site 146891002038 ATP binding site [chemical binding]; other site 146891002039 Q-loop/lid; other site 146891002040 ABC transporter signature motif; other site 146891002041 Walker B; other site 146891002042 D-loop; other site 146891002043 H-loop/switch region; other site 146891002044 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 146891002045 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 146891002046 RNA methyltransferase, RsmE family; Region: TIGR00046 146891002047 Integral membrane protein DUF92; Region: DUF92; pfam01940 146891002048 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 146891002049 active site 146891002050 catalytic triad [active] 146891002051 oxyanion hole [active] 146891002052 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 146891002053 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 146891002054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891002055 Walker A/P-loop; other site 146891002056 ATP binding site [chemical binding]; other site 146891002057 Q-loop/lid; other site 146891002058 ABC transporter signature motif; other site 146891002059 Walker B; other site 146891002060 D-loop; other site 146891002061 H-loop/switch region; other site 146891002062 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 146891002063 aspartate aminotransferase; Provisional; Region: PRK05764 146891002064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891002065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891002066 homodimer interface [polypeptide binding]; other site 146891002067 catalytic residue [active] 146891002068 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 146891002069 active site 146891002070 Fe-S cluster binding site [ion binding]; other site 146891002071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 146891002072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 146891002073 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 146891002074 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 146891002075 C-terminal peptidase (prc); Region: prc; TIGR00225 146891002076 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 146891002077 protein binding site [polypeptide binding]; other site 146891002078 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 146891002079 Catalytic dyad [active] 146891002080 quinolinate synthetase; Provisional; Region: PRK09375 146891002081 TIGR04168 family protein; Region: TIGR04168 146891002082 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 146891002083 Repair protein; Region: Repair_PSII; pfam04536 146891002084 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 146891002085 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 146891002086 active site 146891002087 dimer interface [polypeptide binding]; other site 146891002088 metal binding site [ion binding]; metal-binding site 146891002089 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 146891002090 ATP-grasp domain; Region: ATP-grasp; pfam02222 146891002091 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891002092 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 146891002093 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 146891002094 nucleotide binding pocket [chemical binding]; other site 146891002095 K-X-D-G motif; other site 146891002096 catalytic site [active] 146891002097 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891002098 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 146891002099 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 146891002100 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 146891002101 C factor cell-cell signaling protein; Provisional; Region: PRK09009 146891002102 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 146891002103 NADP binding site [chemical binding]; other site 146891002104 homodimer interface [polypeptide binding]; other site 146891002105 active site 146891002106 chaperone protein DnaJ; Provisional; Region: PRK14276 146891002107 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891002108 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 146891002109 Ion channel; Region: Ion_trans_2; pfam07885 146891002110 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 146891002111 TrkA-N domain; Region: TrkA_N; pfam02254 146891002112 TrkA-C domain; Region: TrkA_C; pfam02080 146891002113 PBP superfamily domain; Region: PBP_like_2; cl17296 146891002114 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 146891002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002116 dimer interface [polypeptide binding]; other site 146891002117 conserved gate region; other site 146891002118 putative PBP binding loops; other site 146891002119 ABC-ATPase subunit interface; other site 146891002120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 146891002121 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 146891002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002123 dimer interface [polypeptide binding]; other site 146891002124 conserved gate region; other site 146891002125 putative PBP binding loops; other site 146891002126 ABC-ATPase subunit interface; other site 146891002127 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 146891002128 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 146891002129 Walker A/P-loop; other site 146891002130 ATP binding site [chemical binding]; other site 146891002131 Q-loop/lid; other site 146891002132 ABC transporter signature motif; other site 146891002133 Walker B; other site 146891002134 D-loop; other site 146891002135 H-loop/switch region; other site 146891002136 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 146891002137 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 146891002138 putative active site [active] 146891002139 putative metal binding site [ion binding]; other site 146891002140 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 146891002141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002142 ATP binding site [chemical binding]; other site 146891002143 putative Mg++ binding site [ion binding]; other site 146891002144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002145 nucleotide binding region [chemical binding]; other site 146891002146 ATP-binding site [chemical binding]; other site 146891002147 DEAD/H associated; Region: DEAD_assoc; pfam08494 146891002148 ATP-dependent DNA ligase; Validated; Region: PRK09247 146891002149 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 146891002150 active site 146891002151 DNA binding site [nucleotide binding] 146891002152 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 146891002153 DNA binding site [nucleotide binding] 146891002154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 146891002155 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 146891002156 translation initiation factor IF-2; Validated; Region: infB; PRK05306 146891002157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 146891002158 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 146891002159 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 146891002160 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 146891002161 Thf1-like protein; Reviewed; Region: PRK13266 146891002162 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 146891002163 Clp protease; Region: CLP_protease; pfam00574 146891002164 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891002165 oligomer interface [polypeptide binding]; other site 146891002166 active site residues [active] 146891002167 cell division protein; Validated; Region: ftsH; CHL00176 146891002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002169 Walker A motif; other site 146891002170 ATP binding site [chemical binding]; other site 146891002171 Walker B motif; other site 146891002172 arginine finger; other site 146891002173 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891002174 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 146891002175 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 146891002176 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 146891002177 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 146891002178 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 146891002179 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 146891002180 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 146891002181 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 146891002182 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 146891002183 HlyD family secretion protein; Region: HlyD_3; pfam13437 146891002184 DevC protein; Region: devC; TIGR01185 146891002185 FtsX-like permease family; Region: FtsX; pfam02687 146891002186 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 146891002187 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 146891002188 Walker A/P-loop; other site 146891002189 ATP binding site [chemical binding]; other site 146891002190 Q-loop/lid; other site 146891002191 ABC transporter signature motif; other site 146891002192 Walker B; other site 146891002193 D-loop; other site 146891002194 H-loop/switch region; other site 146891002195 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 146891002196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002197 active site 146891002198 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 146891002199 rRNA interaction site [nucleotide binding]; other site 146891002200 S8 interaction site; other site 146891002201 putative laminin-1 binding site; other site 146891002202 elongation factor Ts; Reviewed; Region: tsf; PRK12332 146891002203 UBA/TS-N domain; Region: UBA; pfam00627 146891002204 Elongation factor TS; Region: EF_TS; pfam00889 146891002205 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 146891002206 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 146891002207 generic binding surface II; other site 146891002208 ssDNA binding site; other site 146891002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002210 ATP binding site [chemical binding]; other site 146891002211 putative Mg++ binding site [ion binding]; other site 146891002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002213 nucleotide binding region [chemical binding]; other site 146891002214 ATP-binding site [chemical binding]; other site 146891002215 sulfite reductase subunit beta; Provisional; Region: PRK13504 146891002216 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 146891002217 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 146891002218 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 146891002219 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 146891002220 geranylgeranyl reductase; Region: ChlP; TIGR02028 146891002221 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 146891002222 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 146891002223 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 146891002224 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 146891002225 G1 box; other site 146891002226 putative GEF interaction site [polypeptide binding]; other site 146891002227 GTP/Mg2+ binding site [chemical binding]; other site 146891002228 Switch I region; other site 146891002229 G2 box; other site 146891002230 G3 box; other site 146891002231 Switch II region; other site 146891002232 G4 box; other site 146891002233 G5 box; other site 146891002234 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 146891002235 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 146891002236 Domain of unknown function (DUF309); Region: DUF309; pfam03745 146891002237 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 146891002238 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 146891002239 Walker A/P-loop; other site 146891002240 ATP binding site [chemical binding]; other site 146891002241 Q-loop/lid; other site 146891002242 ABC transporter signature motif; other site 146891002243 Walker B; other site 146891002244 D-loop; other site 146891002245 H-loop/switch region; other site 146891002246 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 146891002247 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 146891002248 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 146891002249 substrate binding site [chemical binding]; other site 146891002250 hexamer interface [polypeptide binding]; other site 146891002251 metal binding site [ion binding]; metal-binding site 146891002252 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 146891002253 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 146891002254 putative active site [active] 146891002255 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 146891002256 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 146891002257 tRNA; other site 146891002258 putative tRNA binding site [nucleotide binding]; other site 146891002259 putative NADP binding site [chemical binding]; other site 146891002260 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 146891002261 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 146891002262 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 146891002263 ligand binding site; other site 146891002264 oligomer interface; other site 146891002265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002266 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 146891002267 dimer interface [polypeptide binding]; other site 146891002268 N-terminal domain interface [polypeptide binding]; other site 146891002269 sulfate 1 binding site; other site 146891002270 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 146891002271 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 146891002272 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 146891002273 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 146891002274 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 146891002275 putative active site [active] 146891002276 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 146891002277 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 146891002278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 146891002279 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 146891002280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002282 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 146891002283 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 146891002284 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 146891002285 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 146891002286 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 146891002287 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 146891002288 putative active site [active] 146891002289 catalytic triad [active] 146891002290 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 146891002291 intersubunit interface [polypeptide binding]; other site 146891002292 active site 146891002293 zinc binding site [ion binding]; other site 146891002294 Na+ binding site [ion binding]; other site 146891002295 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 146891002296 active site 146891002297 intersubunit interface [polypeptide binding]; other site 146891002298 catalytic residue [active] 146891002299 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891002300 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 146891002301 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 146891002302 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 146891002303 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 146891002304 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 146891002305 active site 146891002306 tartrate dehydrogenase; Region: TTC; TIGR02089 146891002307 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 146891002308 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 146891002309 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 146891002310 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 146891002311 trimer interface [polypeptide binding]; other site 146891002312 active site 146891002313 UDP-GlcNAc binding site [chemical binding]; other site 146891002314 lipid binding site [chemical binding]; lipid-binding site 146891002315 gamma-glutamyl kinase; Provisional; Region: PRK05429 146891002316 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 146891002317 nucleotide binding site [chemical binding]; other site 146891002318 homotetrameric interface [polypeptide binding]; other site 146891002319 putative phosphate binding site [ion binding]; other site 146891002320 putative allosteric binding site; other site 146891002321 PUA domain; Region: PUA; pfam01472 146891002322 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 146891002323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002324 active site 146891002325 motif I; other site 146891002326 motif II; other site 146891002327 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 146891002328 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 146891002329 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 146891002330 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 146891002331 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 146891002332 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 146891002333 catalytic residues [active] 146891002334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891002335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002336 NAD(P) binding site [chemical binding]; other site 146891002337 active site 146891002338 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 146891002339 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 146891002340 trimer interface [polypeptide binding]; other site 146891002341 putative Zn binding site [ion binding]; other site 146891002342 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 146891002343 GSH binding site [chemical binding]; other site 146891002344 catalytic residues [active] 146891002345 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 146891002346 NADH(P)-binding; Region: NAD_binding_10; pfam13460 146891002347 NAD(P) binding site [chemical binding]; other site 146891002348 putative active site [active] 146891002349 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 146891002350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 146891002351 minor groove reading motif; other site 146891002352 helix-hairpin-helix signature motif; other site 146891002353 substrate binding pocket [chemical binding]; other site 146891002354 active site 146891002355 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 146891002356 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 146891002357 Walker A/P-loop; other site 146891002358 ATP binding site [chemical binding]; other site 146891002359 Q-loop/lid; other site 146891002360 ABC transporter signature motif; other site 146891002361 Walker B; other site 146891002362 D-loop; other site 146891002363 H-loop/switch region; other site 146891002364 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 146891002365 Ferritin-like domain; Region: Ferritin; pfam00210 146891002366 ferroxidase diiron center [ion binding]; other site 146891002367 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 146891002368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 146891002369 putative switch regulator; other site 146891002370 non-specific DNA interactions [nucleotide binding]; other site 146891002371 DNA binding site [nucleotide binding] 146891002372 sequence specific DNA binding site [nucleotide binding]; other site 146891002373 putative cAMP binding site [chemical binding]; other site 146891002374 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 146891002375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891002376 Walker A/P-loop; other site 146891002377 ATP binding site [chemical binding]; other site 146891002378 Q-loop/lid; other site 146891002379 ABC transporter signature motif; other site 146891002380 Walker B; other site 146891002381 D-loop; other site 146891002382 H-loop/switch region; other site 146891002383 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 146891002384 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 146891002385 [2Fe-2S] cluster binding site [ion binding]; other site 146891002386 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 146891002387 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 146891002388 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 146891002389 Walker A/P-loop; other site 146891002390 ATP binding site [chemical binding]; other site 146891002391 Q-loop/lid; other site 146891002392 ABC transporter signature motif; other site 146891002393 Walker B; other site 146891002394 D-loop; other site 146891002395 H-loop/switch region; other site 146891002396 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 146891002397 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 146891002398 Walker A/P-loop; other site 146891002399 ATP binding site [chemical binding]; other site 146891002400 Q-loop/lid; other site 146891002401 ABC transporter signature motif; other site 146891002402 Walker B; other site 146891002403 D-loop; other site 146891002404 H-loop/switch region; other site 146891002405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 146891002406 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 146891002407 TM-ABC transporter signature motif; other site 146891002408 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 146891002409 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 146891002410 TM-ABC transporter signature motif; other site 146891002411 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 146891002412 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 146891002413 putative ligand binding site [chemical binding]; other site 146891002414 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891002415 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 146891002416 UreF; Region: UreF; pfam01730 146891002417 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 146891002418 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 146891002419 dimer interface [polypeptide binding]; other site 146891002420 catalytic residues [active] 146891002421 UreD urease accessory protein; Region: UreD; pfam01774 146891002422 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 146891002423 alpha-gamma subunit interface [polypeptide binding]; other site 146891002424 beta-gamma subunit interface [polypeptide binding]; other site 146891002425 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 146891002426 gamma-beta subunit interface [polypeptide binding]; other site 146891002427 alpha-beta subunit interface [polypeptide binding]; other site 146891002428 urease subunit alpha; Reviewed; Region: ureC; PRK13207 146891002429 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 146891002430 subunit interactions [polypeptide binding]; other site 146891002431 active site 146891002432 flap region; other site 146891002433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002434 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 146891002435 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 146891002436 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 146891002437 active site 146891002438 catalytic site [active] 146891002439 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 146891002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002441 active site 146891002442 motif I; other site 146891002443 motif II; other site 146891002444 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 146891002445 active site 146891002446 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 146891002447 Bacitracin resistance protein BacA; Region: BacA; pfam02673 146891002448 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 146891002449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891002450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 146891002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891002452 Walker A/P-loop; other site 146891002453 ATP binding site [chemical binding]; other site 146891002454 Q-loop/lid; other site 146891002455 ABC transporter signature motif; other site 146891002456 Walker B; other site 146891002457 D-loop; other site 146891002458 H-loop/switch region; other site 146891002459 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 146891002460 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 146891002461 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 146891002462 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 146891002463 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 146891002464 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 146891002465 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 146891002466 catalytic site [active] 146891002467 subunit interface [polypeptide binding]; other site 146891002468 similar to hypothetical protein 146891002469 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 146891002470 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 146891002471 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 146891002472 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 146891002473 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 146891002474 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 146891002475 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 146891002476 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 146891002477 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 146891002478 active site 146891002479 PHP Thumb interface [polypeptide binding]; other site 146891002480 metal binding site [ion binding]; metal-binding site 146891002481 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 146891002482 generic binding surface I; other site 146891002483 generic binding surface II; other site 146891002484 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 146891002485 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 146891002486 16S/18S rRNA binding site [nucleotide binding]; other site 146891002487 S13e-L30e interaction site [polypeptide binding]; other site 146891002488 25S rRNA binding site [nucleotide binding]; other site 146891002489 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 146891002490 RuvA N terminal domain; Region: RuvA_N; pfam01330 146891002491 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 146891002492 EamA-like transporter family; Region: EamA; pfam00892 146891002493 DNA primase; Validated; Region: dnaG; PRK05667 146891002494 CHC2 zinc finger; Region: zf-CHC2; pfam01807 146891002495 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 146891002496 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 146891002497 active site 146891002498 metal binding site [ion binding]; metal-binding site 146891002499 interdomain interaction site; other site 146891002500 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 146891002501 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 146891002502 active site 146891002503 DNA binding site [nucleotide binding] 146891002504 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 146891002505 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 146891002506 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 146891002507 Catalytic site [active] 146891002508 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 146891002509 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 146891002510 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 146891002511 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 146891002512 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 146891002513 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 146891002514 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 146891002515 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 146891002516 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 146891002517 alpha subunit interface [polypeptide binding]; other site 146891002518 TPP binding site [chemical binding]; other site 146891002519 heterodimer interface [polypeptide binding]; other site 146891002520 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891002521 protein-export membrane protein SecD; Region: secD; TIGR01129 146891002522 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 146891002523 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 146891002524 Protein export membrane protein; Region: SecD_SecF; cl14618 146891002525 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 146891002526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 146891002527 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 146891002528 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 146891002529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 146891002530 active site residue [active] 146891002531 GUN4-like; Region: GUN4; pfam05419 146891002532 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 146891002533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 146891002534 ATP binding site [chemical binding]; other site 146891002535 Mg2+ binding site [ion binding]; other site 146891002536 G-X-G motif; other site 146891002537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 146891002538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891002539 S-adenosylmethionine binding site [chemical binding]; other site 146891002540 glutamine synthetase, type I; Region: GlnA; TIGR00653 146891002541 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 146891002542 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 146891002543 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 146891002544 homodimer interface [polypeptide binding]; other site 146891002545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891002546 catalytic residue [active] 146891002547 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 146891002548 nucleoside/Zn binding site; other site 146891002549 dimer interface [polypeptide binding]; other site 146891002550 catalytic motif [active] 146891002551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891002552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891002553 catalytic residue [active] 146891002554 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 146891002555 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 146891002556 G1 box; other site 146891002557 GTP/Mg2+ binding site [chemical binding]; other site 146891002558 G2 box; other site 146891002559 Switch I region; other site 146891002560 G3 box; other site 146891002561 Switch II region; other site 146891002562 G4 box; other site 146891002563 G5 box; other site 146891002564 Domain of unknown function (DUF697); Region: DUF697; pfam05128 146891002565 lipoprotein signal peptidase; Provisional; Region: PRK14792 146891002566 lipoprotein signal peptidase; Provisional; Region: PRK14787 146891002567 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 146891002568 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 146891002569 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 146891002570 FtsX-like permease family; Region: FtsX; pfam02687 146891002571 pyruvate kinase; Provisional; Region: PRK06354 146891002572 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 146891002573 domain interfaces; other site 146891002574 active site 146891002575 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 146891002576 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 146891002577 putative metal binding site [ion binding]; other site 146891002578 YGGT family; Region: YGGT; pfam02325 146891002579 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 146891002580 threonine dehydratase; Reviewed; Region: PRK09224 146891002581 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 146891002582 tetramer interface [polypeptide binding]; other site 146891002583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891002584 catalytic residue [active] 146891002585 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 146891002586 putative Ile/Val binding site [chemical binding]; other site 146891002587 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 146891002588 putative Ile/Val binding site [chemical binding]; other site 146891002589 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 146891002590 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 146891002591 TPP-binding site; other site 146891002592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891002593 PYR/PP interface [polypeptide binding]; other site 146891002594 dimer interface [polypeptide binding]; other site 146891002595 TPP binding site [chemical binding]; other site 146891002596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891002597 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 146891002598 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 146891002599 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 146891002600 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891002601 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 146891002602 catalytic triad [active] 146891002603 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 146891002604 heat shock protein 90; Provisional; Region: PRK05218 146891002605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891002606 ATP binding site [chemical binding]; other site 146891002607 Mg2+ binding site [ion binding]; other site 146891002608 G-X-G motif; other site 146891002609 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 146891002610 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 146891002611 motif 1; other site 146891002612 dimer interface [polypeptide binding]; other site 146891002613 active site 146891002614 motif 3; other site 146891002615 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 146891002616 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 146891002617 active site 146891002618 dimerization interface [polypeptide binding]; other site 146891002619 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 146891002620 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891002621 catalytic loop [active] 146891002622 iron binding site [ion binding]; other site 146891002623 molecular chaperone DnaK; Provisional; Region: PRK13410 146891002624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 146891002625 nucleotide binding site [chemical binding]; other site 146891002626 chaperone protein DnaJ; Provisional; Region: PRK14299 146891002627 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891002628 HSP70 interaction site [polypeptide binding]; other site 146891002629 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 146891002630 substrate binding site [polypeptide binding]; other site 146891002631 dimer interface [polypeptide binding]; other site 146891002632 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 146891002633 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 146891002634 active site 146891002635 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 146891002636 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 146891002637 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 146891002638 dimerization interface [polypeptide binding]; other site 146891002639 active site 146891002640 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 146891002641 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 146891002642 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 146891002643 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 146891002644 active site 146891002645 substrate binding site [chemical binding]; other site 146891002646 cosubstrate binding site; other site 146891002647 catalytic site [active] 146891002648 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 146891002649 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 146891002650 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 146891002651 dimer interface [polypeptide binding]; other site 146891002652 active site 146891002653 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 146891002654 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 146891002655 HIGH motif; other site 146891002656 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 146891002657 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891002658 active site 146891002659 KMSKS motif; other site 146891002660 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 146891002661 tRNA binding surface [nucleotide binding]; other site 146891002662 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 146891002663 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 146891002664 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 146891002665 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 146891002666 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891002667 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 146891002668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891002669 catalytic residue [active] 146891002670 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 146891002671 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 146891002672 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 146891002673 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 146891002674 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 146891002675 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 146891002676 active site 146891002677 (T/H)XGH motif; other site 146891002678 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 146891002679 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 146891002680 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 146891002681 GIY-YIG motif/motif A; other site 146891002682 active site 146891002683 catalytic site [active] 146891002684 putative DNA binding site [nucleotide binding]; other site 146891002685 metal binding site [ion binding]; metal-binding site 146891002686 UvrB/uvrC motif; Region: UVR; pfam02151 146891002687 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 146891002688 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 146891002689 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 146891002690 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 146891002691 active site 146891002692 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 146891002693 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002694 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 146891002695 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002696 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 146891002697 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 146891002698 homodimer interface [polypeptide binding]; other site 146891002699 substrate-cofactor binding pocket; other site 146891002700 catalytic residue [active] 146891002701 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 146891002702 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 146891002703 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 146891002704 substrate binding pocket [chemical binding]; other site 146891002705 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 146891002706 B12 binding site [chemical binding]; other site 146891002707 cobalt ligand [ion binding]; other site 146891002708 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 146891002709 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 146891002710 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 146891002711 ATP adenylyltransferase; Region: ATP_transf; pfam09830 146891002712 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891002713 HSP70 interaction site [polypeptide binding]; other site 146891002714 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 146891002715 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 146891002716 putative tRNA-binding site [nucleotide binding]; other site 146891002717 B3/4 domain; Region: B3_4; pfam03483 146891002718 tRNA synthetase B5 domain; Region: B5; smart00874 146891002719 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 146891002720 dimer interface [polypeptide binding]; other site 146891002721 motif 1; other site 146891002722 motif 3; other site 146891002723 motif 2; other site 146891002724 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 146891002725 ribosomal protein L33; Region: rpl33; CHL00104 146891002726 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 146891002727 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 146891002728 RNB domain; Region: RNB; pfam00773 146891002729 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 146891002730 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 146891002731 active site 146891002732 HIGH motif; other site 146891002733 KMSKS motif; other site 146891002734 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 146891002735 tRNA binding surface [nucleotide binding]; other site 146891002736 anticodon binding site; other site 146891002737 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 146891002738 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 146891002739 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 146891002740 homotrimer interface [polypeptide binding]; other site 146891002741 Walker A motif; other site 146891002742 GTP binding site [chemical binding]; other site 146891002743 Walker B motif; other site 146891002744 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 146891002745 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 146891002746 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891002747 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 146891002748 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 146891002749 dimer interface [polypeptide binding]; other site 146891002750 decamer (pentamer of dimers) interface [polypeptide binding]; other site 146891002751 catalytic triad [active] 146891002752 peroxidatic and resolving cysteines [active] 146891002753 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 146891002754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002755 Walker A motif; other site 146891002756 ATP binding site [chemical binding]; other site 146891002757 Walker B motif; other site 146891002758 arginine finger; other site 146891002759 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891002760 ribosomal protein L32; Validated; Region: rpl32; CHL00152 146891002761 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 146891002762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002763 motif II; other site 146891002764 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 146891002765 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 146891002766 Predicted membrane protein [Function unknown]; Region: COG2119 146891002767 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 146891002768 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 146891002769 Predicted membrane protein [Function unknown]; Region: COG2119 146891002770 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 146891002771 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 146891002772 RNB domain; Region: RNB; pfam00773 146891002773 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 146891002774 RNA binding site [nucleotide binding]; other site 146891002775 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 146891002776 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 146891002777 diiron binding motif [ion binding]; other site 146891002778 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 146891002779 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 146891002780 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 146891002781 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 146891002782 putative active site [active] 146891002783 substrate binding site [chemical binding]; other site 146891002784 putative cosubstrate binding site; other site 146891002785 catalytic site [active] 146891002786 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 146891002787 substrate binding site [chemical binding]; other site 146891002788 Integral membrane protein TerC family; Region: TerC; cl10468 146891002789 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 146891002790 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 146891002791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002792 ATP binding site [chemical binding]; other site 146891002793 putative Mg++ binding site [ion binding]; other site 146891002794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002795 nucleotide binding region [chemical binding]; other site 146891002796 ATP-binding site [chemical binding]; other site 146891002797 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 146891002798 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 146891002799 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 146891002800 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 146891002801 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 146891002802 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 146891002803 dihydrodipicolinate reductase; Provisional; Region: PRK00048 146891002804 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 146891002805 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 146891002806 magnesium chelatase subunit H; Provisional; Region: PRK12493 146891002807 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 146891002808 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002809 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002810 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 146891002811 dihydropteroate synthase; Region: DHPS; TIGR01496 146891002812 substrate binding pocket [chemical binding]; other site 146891002813 dimer interface [polypeptide binding]; other site 146891002814 inhibitor binding site; inhibition site 146891002815 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 146891002816 triosephosphate isomerase; Provisional; Region: PRK14565 146891002817 substrate binding site [chemical binding]; other site 146891002818 dimer interface [polypeptide binding]; other site 146891002819 catalytic triad [active] 146891002820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891002821 RNA binding surface [nucleotide binding]; other site 146891002822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 146891002823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891002824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891002825 Walker A/P-loop; other site 146891002826 ATP binding site [chemical binding]; other site 146891002827 Q-loop/lid; other site 146891002828 ABC transporter signature motif; other site 146891002829 Walker B; other site 146891002830 D-loop; other site 146891002831 H-loop/switch region; other site 146891002832 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 146891002833 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891002834 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 146891002835 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 146891002836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891002837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 146891002838 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 146891002839 IMP binding site; other site 146891002840 dimer interface [polypeptide binding]; other site 146891002841 interdomain contacts; other site 146891002842 partial ornithine binding site; other site 146891002843 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 146891002844 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 146891002845 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 146891002846 L-asparaginase II; Region: Asparaginase_II; pfam06089 146891002847 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 146891002848 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 146891002849 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 146891002850 Walker A/P-loop; other site 146891002851 ATP binding site [chemical binding]; other site 146891002852 Q-loop/lid; other site 146891002853 ABC transporter signature motif; other site 146891002854 Walker B; other site 146891002855 D-loop; other site 146891002856 H-loop/switch region; other site 146891002857 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 146891002858 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 146891002859 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 146891002860 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 146891002861 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 146891002862 active site 146891002863 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 146891002864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891002865 active site 146891002866 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 146891002867 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 146891002868 ski2-like helicase; Provisional; Region: PRK00254 146891002869 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 146891002870 AAA domain; Region: AAA_18; pfam13238 146891002871 active site 146891002872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891002873 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 146891002874 active site pocket [active] 146891002875 oxyanion hole [active] 146891002876 catalytic triad [active] 146891002877 active site nucleophile [active] 146891002878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 146891002879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891002880 Coenzyme A binding pocket [chemical binding]; other site 146891002881 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891002882 Protein of unknown function, DUF393; Region: DUF393; pfam04134 146891002883 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891002884 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 146891002885 aminopeptidase N; Provisional; Region: pepN; PRK14015 146891002886 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 146891002887 Zn binding site [ion binding]; other site 146891002888 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 146891002889 ATP-grasp domain; Region: ATP-grasp; pfam02222 146891002890 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 146891002891 catalytic residues [active] 146891002892 dimer interface [polypeptide binding]; other site 146891002893 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 146891002894 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 146891002895 FMN binding site [chemical binding]; other site 146891002896 active site 146891002897 catalytic residues [active] 146891002898 substrate binding site [chemical binding]; other site 146891002899 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 146891002900 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 146891002901 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 146891002902 active site 146891002903 Restriction endonuclease; Region: Mrr_cat; pfam04471 146891002904 MAPEG family; Region: MAPEG; pfam01124 146891002905 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 146891002906 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 146891002907 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891002908 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 146891002909 OsmC-like protein; Region: OsmC; pfam02566 146891002910 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 146891002911 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 146891002912 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 146891002913 dimer interface [polypeptide binding]; other site 146891002914 putative PBP binding regions; other site 146891002915 ABC-ATPase subunit interface; other site 146891002916 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 146891002917 metal binding site 2 [ion binding]; metal-binding site 146891002918 putative DNA binding helix; other site 146891002919 metal binding site 1 [ion binding]; metal-binding site 146891002920 dimer interface [polypeptide binding]; other site 146891002921 structural Zn2+ binding site [ion binding]; other site 146891002922 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 146891002923 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 146891002924 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 146891002925 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 146891002926 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 146891002927 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 146891002928 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 146891002929 P-loop, Walker A motif; other site 146891002930 Base recognition motif; other site 146891002931 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 146891002932 PQQ-like domain; Region: PQQ_2; pfam13360 146891002933 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 146891002934 structural tetrad; other site 146891002935 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 146891002936 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 146891002937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 146891002938 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 146891002939 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 146891002940 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 146891002941 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 146891002942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002944 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 146891002945 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891002946 substrate binding site [chemical binding]; other site 146891002947 ATP binding site [chemical binding]; other site 146891002948 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 146891002949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 146891002950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 146891002951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 146891002952 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 146891002953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 146891002954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002955 dimer interface [polypeptide binding]; other site 146891002956 conserved gate region; other site 146891002957 putative PBP binding loops; other site 146891002958 ABC-ATPase subunit interface; other site 146891002959 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 146891002960 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 146891002961 homoserine dehydrogenase; Provisional; Region: PRK06349 146891002962 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 146891002963 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 146891002964 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 146891002965 Fe-S metabolism associated domain; Region: SufE; cl00951 146891002966 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 146891002967 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 146891002968 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 146891002969 active site 146891002970 putative DNA-binding cleft [nucleotide binding]; other site 146891002971 dimer interface [polypeptide binding]; other site 146891002972 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 146891002973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 146891002974 Walker A motif; other site 146891002975 ATP binding site [chemical binding]; other site 146891002976 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 146891002977 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 146891002978 Cytochrome c; Region: Cytochrom_C; pfam00034 146891002979 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 146891002980 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 146891002981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891002982 S-adenosylmethionine binding site [chemical binding]; other site 146891002983 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 146891002984 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 146891002985 putative active site [active] 146891002986 oxyanion strand; other site 146891002987 catalytic triad [active] 146891002988 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 146891002989 catalytic residues [active] 146891002990 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 146891002991 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 146891002992 phosphate binding site [ion binding]; other site 146891002993 DNA gyrase subunit A; Validated; Region: PRK05560 146891002994 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 146891002995 CAP-like domain; other site 146891002996 active site 146891002997 primary dimer interface [polypeptide binding]; other site 146891002998 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002999 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891003000 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891003001 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891003002 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891003003 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 146891003004 lycopene cyclase; Region: lycopene_cycl; TIGR01789 146891003005 Uncharacterized conserved protein [Function unknown]; Region: COG1543 146891003006 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 146891003007 active site 146891003008 substrate binding site [chemical binding]; other site 146891003009 catalytic site [active] 146891003010 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 146891003011 2-isopropylmalate synthase; Validated; Region: PRK00915 146891003012 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 146891003013 active site 146891003014 catalytic residues [active] 146891003015 metal binding site [ion binding]; metal-binding site 146891003016 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 146891003017 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 146891003018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 146891003019 Zn2+ binding site [ion binding]; other site 146891003020 Mg2+ binding site [ion binding]; other site 146891003021 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 146891003022 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 146891003023 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 146891003024 homodimer interface [polypeptide binding]; other site 146891003025 NADP binding site [chemical binding]; other site 146891003026 substrate binding site [chemical binding]; other site 146891003027 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 146891003028 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 146891003029 substrate binding pocket [chemical binding]; other site 146891003030 chain length determination region; other site 146891003031 substrate-Mg2+ binding site; other site 146891003032 catalytic residues [active] 146891003033 aspartate-rich region 1; other site 146891003034 active site lid residues [active] 146891003035 aspartate-rich region 2; other site 146891003036 Divergent PAP2 family; Region: DUF212; pfam02681 146891003037 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 146891003038 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891003039 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 146891003040 catalytic triad [active] 146891003041 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 146891003042 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 146891003043 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 146891003044 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 146891003045 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 146891003046 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 146891003047 dimerization interface [polypeptide binding]; other site 146891003048 FAD binding pocket [chemical binding]; other site 146891003049 FAD binding motif [chemical binding]; other site 146891003050 catalytic residues [active] 146891003051 NAD binding pocket [chemical binding]; other site 146891003052 phosphate binding motif [ion binding]; other site 146891003053 beta-alpha-beta structure motif; other site 146891003054 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 146891003055 hydrophobic ligand binding site; other site 146891003056 adaptive-response sensory kinase; Validated; Region: PRK09303 146891003057 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 146891003058 tetramer interface [polypeptide binding]; other site 146891003059 dimer interface [polypeptide binding]; other site 146891003060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891003061 dimer interface [polypeptide binding]; other site 146891003062 phosphorylation site [posttranslational modification] 146891003063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891003064 ATP binding site [chemical binding]; other site 146891003065 Mg2+ binding site [ion binding]; other site 146891003066 G-X-G motif; other site 146891003067 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 146891003068 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 146891003069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891003070 active site 146891003071 4-alpha-glucanotransferase; Provisional; Region: PRK14508 146891003072 Helix-turn-helix domain; Region: HTH_25; pfam13413 146891003073 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 146891003074 ABC1 family; Region: ABC1; cl17513 146891003075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891003076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891003077 catalytic residue [active] 146891003078 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 146891003079 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 146891003080 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 146891003081 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 146891003082 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 146891003083 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 146891003084 active site 146891003085 NAD binding site [chemical binding]; other site 146891003086 metal binding site [ion binding]; metal-binding site 146891003087 Clp protease ATP binding subunit; Region: clpC; CHL00095 146891003088 Clp amino terminal domain; Region: Clp_N; pfam02861 146891003089 Clp amino terminal domain; Region: Clp_N; pfam02861 146891003090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003091 Walker A motif; other site 146891003092 ATP binding site [chemical binding]; other site 146891003093 Walker B motif; other site 146891003094 arginine finger; other site 146891003095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003096 Walker A motif; other site 146891003097 ATP binding site [chemical binding]; other site 146891003098 Walker B motif; other site 146891003099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 146891003100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 146891003101 diaminopimelate decarboxylase; Region: lysA; TIGR01048 146891003102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 146891003103 active site 146891003104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891003105 substrate binding site [chemical binding]; other site 146891003106 catalytic residues [active] 146891003107 dimer interface [polypeptide binding]; other site 146891003108 TIGR00159 family protein; Region: TIGR00159 146891003109 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 146891003110 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 146891003111 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 146891003112 catalytic residue [active] 146891003113 putative FPP diphosphate binding site; other site 146891003114 putative FPP binding hydrophobic cleft; other site 146891003115 dimer interface [polypeptide binding]; other site 146891003116 putative IPP diphosphate binding site; other site 146891003117 biotin synthase; Region: bioB; TIGR00433 146891003118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003119 FeS/SAM binding site; other site 146891003120 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 146891003121 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 146891003122 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 146891003123 active site residue [active] 146891003124 lipoyl synthase; Provisional; Region: PRK12928 146891003125 recombination protein RecR; Reviewed; Region: recR; PRK00076 146891003126 RecR protein; Region: RecR; pfam02132 146891003127 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 146891003128 putative active site [active] 146891003129 putative metal-binding site [ion binding]; other site 146891003130 tetramer interface [polypeptide binding]; other site 146891003131 PsbP; Region: PsbP; pfam01789 146891003132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891003133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 146891003134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891003135 Walker A/P-loop; other site 146891003136 ATP binding site [chemical binding]; other site 146891003137 Q-loop/lid; other site 146891003138 ABC transporter signature motif; other site 146891003139 Walker B; other site 146891003140 D-loop; other site 146891003141 H-loop/switch region; other site 146891003142 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 146891003143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 146891003144 ATP binding site [chemical binding]; other site 146891003145 Mg++ binding site [ion binding]; other site 146891003146 motif III; other site 146891003147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891003148 nucleotide binding region [chemical binding]; other site 146891003149 ATP-binding site [chemical binding]; other site 146891003150 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 146891003151 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 146891003152 AAA domain; Region: AAA_30; pfam13604 146891003153 Family description; Region: UvrD_C_2; pfam13538 146891003154 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 146891003155 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 146891003156 Family description; Region: UvrD_C_2; pfam13538 146891003157 Phospholipid methyltransferase; Region: PEMT; cl17370 146891003158 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 146891003159 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 146891003160 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 146891003161 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 146891003162 active site 146891003163 hydrophilic channel; other site 146891003164 dimerization interface [polypeptide binding]; other site 146891003165 catalytic residues [active] 146891003166 active site lid [active] 146891003167 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 146891003168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 146891003169 putative acyl-acceptor binding pocket; other site 146891003170 BolA-like protein; Region: BolA; pfam01722 146891003171 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 146891003172 putative GSH binding site [chemical binding]; other site 146891003173 catalytic residues [active] 146891003174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 146891003175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891003176 active site 146891003177 phosphorylation site [posttranslational modification] 146891003178 intermolecular recognition site; other site 146891003179 dimerization interface [polypeptide binding]; other site 146891003180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891003181 DNA binding site [nucleotide binding] 146891003182 carotene isomerase; Region: carot_isom; TIGR02730 146891003183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891003184 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 146891003185 Glucose inhibited division protein A; Region: GIDA; pfam01134 146891003186 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 146891003187 putative high light inducible protein; Region: PHA02337 146891003188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891003189 TPR motif; other site 146891003190 binding surface 146891003191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891003192 binding surface 146891003193 TPR motif; other site 146891003194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891003195 Tetratricopeptide repeat; Region: TPR_16; pfam13432 146891003196 TPR motif; other site 146891003197 binding surface 146891003198 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 146891003199 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 146891003200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891003201 active site 146891003202 YadA-like C-terminal region; Region: YadA; pfam03895 146891003203 Autotransporter beta-domain; Region: Autotransporter; smart00869 146891003204 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 146891003205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891003206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891003207 DNA binding residues [nucleotide binding] 146891003208 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 146891003209 EF-hand domain pair; Region: EF_hand_5; pfam13499 146891003210 Ca2+ binding site [ion binding]; other site 146891003211 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003212 putative high light inducible protein; Region: PHA02337 146891003213 putative high light inducible protein; Region: PHA02337 146891003214 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 146891003215 Protein of unknown function; Region: DUF3721; pfam12518 146891003216 DsrE/DsrF-like family; Region: DrsE; pfam02635 146891003217 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 146891003218 putative high light inducible protein; Region: PHA02337 146891003219 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 146891003220 protein I interface; other site 146891003221 D2 interface; other site 146891003222 protein T interface; other site 146891003223 chlorophyll binding site; other site 146891003224 beta carotene binding site; other site 146891003225 pheophytin binding site; other site 146891003226 manganese-stabilizing polypeptide interface; other site 146891003227 CP43 interface; other site 146891003228 protein L interface; other site 146891003229 oxygen evolving complex binding site; other site 146891003230 bromide binding site; other site 146891003231 quinone binding site; other site 146891003232 Fe binding site [ion binding]; other site 146891003233 core light harvesting interface; other site 146891003234 cytochrome b559 alpha subunit interface; other site 146891003235 cytochrome c-550 interface; other site 146891003236 protein J interface; other site 146891003237 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 146891003238 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891003239 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 146891003240 L-aspartate oxidase; Provisional; Region: PRK06175 146891003241 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 146891003242 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 146891003243 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 146891003244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891003245 RNA binding surface [nucleotide binding]; other site 146891003246 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 146891003247 probable active site [active] 146891003248 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003249 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 146891003250 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891003251 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003252 potassium and/or sodium efflux P-type ATPase, fungal-type; Region: ATPase-IID_K-Na; TIGR01523 146891003253 Kinesin-associated protein (KAP); Region: KAP; pfam05804 146891003254 Protein of unknown function, DUF; Region: DUF411; cl01142 146891003255 Protein of unknown function; Region: DUF3721; pfam12518 146891003256 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891003257 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891003258 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 146891003259 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891003260 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 146891003261 Na2 binding site [ion binding]; other site 146891003262 putative substrate binding site 1 [chemical binding]; other site 146891003263 Na binding site 1 [ion binding]; other site 146891003264 putative substrate binding site 2 [chemical binding]; other site 146891003265 Uncharacterized conserved protein [Function unknown]; Region: COG0397 146891003266 hypothetical protein; Validated; Region: PRK00029 146891003267 Cupin domain; Region: Cupin_2; pfam07883 146891003268 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003269 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 146891003270 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 146891003271 catalytic triad [active] 146891003272 putative high light inducible protein; Region: PHA02337 146891003273 putative high light inducible protein; Region: PHA02337 146891003274 putative high light inducible protein; Region: PHA02337 146891003275 putative high light inducible protein; Region: PHA02337 146891003276 GTP-binding protein YchF; Reviewed; Region: PRK09601 146891003277 YchF GTPase; Region: YchF; cd01900 146891003278 G1 box; other site 146891003279 GTP/Mg2+ binding site [chemical binding]; other site 146891003280 Switch I region; other site 146891003281 G2 box; other site 146891003282 Switch II region; other site 146891003283 G3 box; other site 146891003284 G4 box; other site 146891003285 G5 box; other site 146891003286 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 146891003287 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 146891003288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 146891003289 HlyD family secretion protein; Region: HlyD_3; pfam13437 146891003290 DNA polymerase I; Provisional; Region: PRK05755 146891003291 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 146891003292 active site 146891003293 metal binding site 1 [ion binding]; metal-binding site 146891003294 putative 5' ssDNA interaction site; other site 146891003295 metal binding site 3; metal-binding site 146891003296 metal binding site 2 [ion binding]; metal-binding site 146891003297 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 146891003298 putative DNA binding site [nucleotide binding]; other site 146891003299 putative metal binding site [ion binding]; other site 146891003300 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 146891003301 active site 146891003302 catalytic site [active] 146891003303 substrate binding site [chemical binding]; other site 146891003304 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 146891003305 active site 146891003306 DNA binding site [nucleotide binding] 146891003307 catalytic site [active] 146891003308 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 146891003309 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891003310 active site 146891003311 HIGH motif; other site 146891003312 nucleotide binding site [chemical binding]; other site 146891003313 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 146891003314 KMSKS motif; other site 146891003315 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 146891003316 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 146891003317 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 146891003318 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 146891003319 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 146891003320 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 146891003321 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 146891003322 dimer interface [polypeptide binding]; other site 146891003323 [2Fe-2S] cluster binding site [ion binding]; other site 146891003324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 146891003325 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 146891003326 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 146891003327 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 146891003328 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 146891003329 ligand binding site [chemical binding]; other site 146891003330 homodimer interface [polypeptide binding]; other site 146891003331 NAD(P) binding site [chemical binding]; other site 146891003332 trimer interface B [polypeptide binding]; other site 146891003333 trimer interface A [polypeptide binding]; other site 146891003334 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 146891003335 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 146891003336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 146891003337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 146891003338 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 146891003339 catalytic residues [active] 146891003340 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 146891003341 rRNA binding site [nucleotide binding]; other site 146891003342 predicted 30S ribosome binding site; other site 146891003343 Ycf39; Provisional; Region: ycf39; CHL00194 146891003344 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 146891003345 NAD(P) binding site [chemical binding]; other site 146891003346 putative active site [active] 146891003347 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 146891003348 hydrolase, alpha/beta fold family protein; Region: PLN02824 146891003349 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 146891003350 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 146891003351 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 146891003352 putative valine binding site [chemical binding]; other site 146891003353 dimer interface [polypeptide binding]; other site 146891003354 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 146891003355 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 146891003356 active site 146891003357 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 146891003358 photosystem II protein D2; Region: psbD; CHL00004 146891003359 pheophytin binding site; other site 146891003360 chlorophyll binding site; other site 146891003361 quinone binding site; other site 146891003362 Fe binding site [ion binding]; other site 146891003363 Photosystem II protein; Region: PSII; cl08223 146891003364 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 146891003365 Maf-like protein; Region: Maf; pfam02545 146891003366 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 146891003367 active site 146891003368 dimer interface [polypeptide binding]; other site 146891003369 cobyric acid synthase; Provisional; Region: PRK00784 146891003370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891003371 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 146891003372 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 146891003373 catalytic triad [active] 146891003374 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891003375 catalytic loop [active] 146891003376 iron binding site [ion binding]; other site 146891003377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891003378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 146891003379 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 146891003380 ligand binding site; other site 146891003381 tetramer interface; other site 146891003382 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 146891003383 putative active site [active] 146891003384 putative substrate binding site [chemical binding]; other site 146891003385 putative cosubstrate binding site; other site 146891003386 catalytic site [active] 146891003387 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 146891003388 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 146891003389 metal binding site [ion binding]; metal-binding site 146891003390 Methyltransferase domain; Region: Methyltransf_23; pfam13489 146891003391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003392 S-adenosylmethionine binding site [chemical binding]; other site 146891003393 Rhomboid family; Region: Rhomboid; cl11446 146891003394 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 146891003395 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 146891003396 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 146891003397 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 146891003398 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 146891003399 dimer interface [polypeptide binding]; other site 146891003400 active site 146891003401 motif 2; other site 146891003402 motif 3; other site 146891003403 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 146891003404 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 146891003405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 146891003406 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 146891003407 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 146891003408 flavodoxin FldA; Validated; Region: PRK09267 146891003409 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 146891003410 Uncharacterized conserved protein [Function unknown]; Region: COG4095 146891003411 Membrane transport protein; Region: Mem_trans; cl09117 146891003412 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 146891003413 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 146891003414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003415 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 146891003416 putative ADP-binding pocket [chemical binding]; other site 146891003417 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 146891003418 EamA-like transporter family; Region: EamA; pfam00892 146891003419 EamA-like transporter family; Region: EamA; pfam00892 146891003420 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 146891003421 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 146891003422 tandem repeat interface [polypeptide binding]; other site 146891003423 oligomer interface [polypeptide binding]; other site 146891003424 active site residues [active] 146891003425 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 146891003426 active site 146891003427 homotrimer interaction site [polypeptide binding]; other site 146891003428 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 146891003429 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 146891003430 Bacterial PH domain; Region: DUF304; pfam03703 146891003431 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 146891003432 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 146891003433 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 146891003434 Ycf46; Provisional; Region: ycf46; CHL00195 146891003435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003436 Walker A motif; other site 146891003437 ATP binding site [chemical binding]; other site 146891003438 Walker B motif; other site 146891003439 arginine finger; other site 146891003440 seryl-tRNA synthetase; Provisional; Region: PRK05431 146891003441 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 146891003442 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 146891003443 dimer interface [polypeptide binding]; other site 146891003444 active site 146891003445 motif 1; other site 146891003446 motif 2; other site 146891003447 motif 3; other site 146891003448 RIP metalloprotease RseP; Region: TIGR00054 146891003449 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 146891003450 active site 146891003451 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 146891003452 protein binding site [polypeptide binding]; other site 146891003453 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 146891003454 putative substrate binding region [chemical binding]; other site 146891003455 ribosomal protein S14; Region: rps14; CHL00074 146891003456 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 146891003457 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 146891003458 RNase E interface [polypeptide binding]; other site 146891003459 trimer interface [polypeptide binding]; other site 146891003460 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 146891003461 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 146891003462 RNase E interface [polypeptide binding]; other site 146891003463 trimer interface [polypeptide binding]; other site 146891003464 active site 146891003465 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 146891003466 putative nucleic acid binding region [nucleotide binding]; other site 146891003467 G-X-X-G motif; other site 146891003468 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 146891003469 RNA binding site [nucleotide binding]; other site 146891003470 domain interface; other site 146891003471 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 146891003472 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 146891003473 active site 146891003474 Predicted methyltransferases [General function prediction only]; Region: COG0313 146891003475 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 146891003476 putative SAM binding site [chemical binding]; other site 146891003477 putative homodimer interface [polypeptide binding]; other site 146891003478 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 146891003479 O-Antigen ligase; Region: Wzy_C; cl04850 146891003480 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 146891003481 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 146891003482 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 146891003483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003484 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891003485 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 146891003486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003487 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 146891003488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 146891003489 active site 146891003490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003491 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 146891003492 putative ADP-binding pocket [chemical binding]; other site 146891003493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003494 active site 146891003495 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 146891003496 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 146891003497 Mg++ binding site [ion binding]; other site 146891003498 putative catalytic motif [active] 146891003499 substrate binding site [chemical binding]; other site 146891003500 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891003501 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 146891003502 putative NAD(P) binding site [chemical binding]; other site 146891003503 active site 146891003504 putative substrate binding site [chemical binding]; other site 146891003505 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 146891003506 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 146891003507 Substrate binding site; other site 146891003508 Cupin domain; Region: Cupin_2; cl17218 146891003509 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 146891003510 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 146891003511 NADP-binding site; other site 146891003512 homotetramer interface [polypeptide binding]; other site 146891003513 substrate binding site [chemical binding]; other site 146891003514 homodimer interface [polypeptide binding]; other site 146891003515 active site 146891003516 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 146891003517 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 146891003518 NADP binding site [chemical binding]; other site 146891003519 active site 146891003520 putative substrate binding site [chemical binding]; other site 146891003521 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 146891003522 Chain length determinant protein; Region: Wzz; cl15801 146891003523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003524 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 146891003525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003526 active site 146891003527 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 146891003528 Methyltransferase domain; Region: Methyltransf_23; pfam13489 146891003529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003530 S-adenosylmethionine binding site [chemical binding]; other site 146891003531 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 146891003532 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 146891003533 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 146891003534 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 146891003535 substrate binding site; other site 146891003536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891003538 Walker A/P-loop; other site 146891003539 ATP binding site [chemical binding]; other site 146891003540 Q-loop/lid; other site 146891003541 ABC transporter signature motif; other site 146891003542 Walker B; other site 146891003543 D-loop; other site 146891003544 H-loop/switch region; other site 146891003545 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891003546 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 146891003547 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 146891003548 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 146891003549 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 146891003550 inhibitor-cofactor binding pocket; inhibition site 146891003551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891003552 catalytic residue [active] 146891003553 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 146891003554 putative trimer interface [polypeptide binding]; other site 146891003555 putative active site [active] 146891003556 putative substrate binding site [chemical binding]; other site 146891003557 putative CoA binding site [chemical binding]; other site 146891003558 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 146891003559 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 146891003560 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 146891003561 NAD(P) binding site [chemical binding]; other site 146891003562 homodimer interface [polypeptide binding]; other site 146891003563 substrate binding site [chemical binding]; other site 146891003564 active site 146891003565 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 146891003566 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 146891003567 Mg++ binding site [ion binding]; other site 146891003568 putative catalytic motif [active] 146891003569 putative substrate binding site [chemical binding]; other site 146891003570 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 146891003571 Ligand Binding Site [chemical binding]; other site 146891003572 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 146891003573 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 146891003574 phosphate binding site [ion binding]; other site 146891003575 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 146891003576 conserved cys residue [active] 146891003577 Predicted dehydrogenase [General function prediction only]; Region: COG0579 146891003578 hydroxyglutarate oxidase; Provisional; Region: PRK11728 146891003579 extended (e) SDRs; Region: SDR_e; cd08946 146891003580 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891003581 NAD(P) binding site [chemical binding]; other site 146891003582 active site 146891003583 substrate binding site [chemical binding]; other site 146891003584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891003585 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891003586 extended (e) SDRs; Region: SDR_e; cd08946 146891003587 NAD(P) binding site [chemical binding]; other site 146891003588 active site 146891003589 substrate binding site [chemical binding]; other site 146891003590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003591 S-adenosylmethionine binding site [chemical binding]; other site 146891003592 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 146891003593 NeuB family; Region: NeuB; pfam03102 146891003594 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 146891003595 NeuB binding interface [polypeptide binding]; other site 146891003596 putative substrate binding site [chemical binding]; other site 146891003597 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 146891003598 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 146891003599 active site 146891003600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003601 active site 146891003602 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 146891003603 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 146891003604 NAD binding site [chemical binding]; other site 146891003605 homodimer interface [polypeptide binding]; other site 146891003606 active site 146891003607 substrate binding site [chemical binding]; other site 146891003608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 146891003609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 146891003610 ligand binding site [chemical binding]; other site 146891003611 flexible hinge region; other site 146891003612 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 146891003613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 146891003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891003615 Walker A/P-loop; other site 146891003616 ATP binding site [chemical binding]; other site 146891003617 Q-loop/lid; other site 146891003618 ABC transporter signature motif; other site 146891003619 Walker B; other site 146891003620 D-loop; other site 146891003621 H-loop/switch region; other site 146891003622 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 146891003623 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 146891003624 HlyD family secretion protein; Region: HlyD_3; pfam13437 146891003625 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 146891003626 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 146891003627 RTX N-terminal domain; Region: RTX; pfam02382 146891003628 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 146891003629 Ca2+ binding site [ion binding]; other site 146891003630 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 146891003631 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 146891003632 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 146891003633 Methyltransferase domain; Region: Methyltransf_23; pfam13489 146891003634 Methyltransferase domain; Region: Methyltransf_11; pfam08241 146891003635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891003636 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 146891003637 active site 146891003638 motif I; other site 146891003639 motif II; other site 146891003640 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 146891003641 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 146891003642 active site 146891003643 Substrate binding site; other site 146891003644 Mg++ binding site; other site 146891003645 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 146891003646 dimer interface [polypeptide binding]; other site 146891003647 active site 146891003648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891003649 active site 146891003650 nucleotide binding site [chemical binding]; other site 146891003651 HIGH motif; other site 146891003652 KMSKS motif; other site 146891003653 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 146891003654 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891003655 putative ribose interaction site [chemical binding]; other site 146891003656 putative ADP binding site [chemical binding]; other site 146891003657 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891003658 extended (e) SDRs; Region: SDR_e; cd08946 146891003659 NAD(P) binding site [chemical binding]; other site 146891003660 active site 146891003661 substrate binding site [chemical binding]; other site 146891003662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003663 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 146891003664 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 146891003665 active site 146891003666 Methyltransferase domain; Region: Methyltransf_31; pfam13847 146891003667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003668 S-adenosylmethionine binding site [chemical binding]; other site 146891003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 146891003670 sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324 146891003671 sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323 146891003672 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 146891003673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891003674 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891003675 Walker A/P-loop; other site 146891003676 ATP binding site [chemical binding]; other site 146891003677 Q-loop/lid; other site 146891003678 ABC transporter signature motif; other site 146891003679 Walker B; other site 146891003680 D-loop; other site 146891003681 H-loop/switch region; other site 146891003682 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 146891003683 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 146891003684 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 146891003685 NAD(P) binding site [chemical binding]; other site 146891003686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003687 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 146891003688 NAD(P) binding site [chemical binding]; other site 146891003689 active site 146891003690 transketolase; Reviewed; Region: PRK05899 146891003691 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 146891003692 TPP-binding site [chemical binding]; other site 146891003693 dimer interface [polypeptide binding]; other site 146891003694 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 146891003695 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891003696 PYR/PP interface [polypeptide binding]; other site 146891003697 dimer interface [polypeptide binding]; other site 146891003698 TPP binding site [chemical binding]; other site 146891003699 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891003700 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891003701 extended (e) SDRs; Region: SDR_e; cd08946 146891003702 NAD(P) binding site [chemical binding]; other site 146891003703 active site 146891003704 substrate binding site [chemical binding]; other site 146891003705 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 146891003706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891003707 UDP-galactopyranose mutase; Region: GLF; pfam03275 146891003708 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 146891003709 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 146891003710 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 146891003711 Catalytic site [active] 146891003712 ornithine carbamoyltransferase; Provisional; Region: PRK00779 146891003713 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 146891003714 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 146891003715 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 146891003716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003717 Walker A motif; other site 146891003718 ATP binding site [chemical binding]; other site 146891003719 Walker B motif; other site 146891003720 arginine finger; other site 146891003721 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891003722 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 146891003723 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 146891003724 catalytic motif [active] 146891003725 Zn binding site [ion binding]; other site 146891003726 RibD C-terminal domain; Region: RibD_C; cl17279 146891003727 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 146891003728 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 146891003729 active site 146891003730 putative homodimer interface [polypeptide binding]; other site 146891003731 SAM binding site [chemical binding]; other site 146891003732 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 146891003733 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 146891003734 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 146891003735 ATP-NAD kinase; Region: NAD_kinase; pfam01513 146891003736 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 146891003737 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 146891003738 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 146891003739 dimer interface [polypeptide binding]; other site 146891003740 motif 1; other site 146891003741 active site 146891003742 motif 2; other site 146891003743 motif 3; other site 146891003744 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 146891003745 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 146891003746 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 146891003747 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 146891003748 active site 146891003749 Riboflavin kinase; Region: Flavokinase; smart00904 146891003750 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 146891003751 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 146891003752 thiamine phosphate binding site [chemical binding]; other site 146891003753 active site 146891003754 pyrophosphate binding site [ion binding]; other site 146891003755 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 146891003756 thiS-thiF/thiG interaction site; other site 146891003757 AIR carboxylase; Region: AIRC; smart01001 146891003758 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 146891003759 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 146891003760 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 146891003761 homotrimer interaction site [polypeptide binding]; other site 146891003762 zinc binding site [ion binding]; other site 146891003763 CDP-binding sites; other site 146891003764 GTPase Era; Reviewed; Region: era; PRK00089 146891003765 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 146891003766 G1 box; other site 146891003767 GTP/Mg2+ binding site [chemical binding]; other site 146891003768 Switch I region; other site 146891003769 G2 box; other site 146891003770 Switch II region; other site 146891003771 G3 box; other site 146891003772 G4 box; other site 146891003773 G5 box; other site 146891003774 KH domain; Region: KH_2; pfam07650 146891003775 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 146891003776 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 146891003777 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 146891003778 PhoH-like protein; Region: PhoH; pfam02562 146891003779 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 146891003780 signal recognition particle protein; Provisional; Region: PRK10867 146891003781 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 146891003782 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 146891003783 P loop; other site 146891003784 GTP binding site [chemical binding]; other site 146891003785 Signal peptide binding domain; Region: SRP_SPB; pfam02978 146891003786 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 146891003787 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 146891003788 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 146891003789 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 146891003790 tetramer interface [polypeptide binding]; other site 146891003791 TPP-binding site [chemical binding]; other site 146891003792 heterodimer interface [polypeptide binding]; other site 146891003793 phosphorylation loop region [posttranslational modification] 146891003794 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891003795 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891003796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891003797 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891003798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891003799 DNA binding residues [nucleotide binding] 146891003800 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 146891003801 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 146891003802 putative substrate binding site [chemical binding]; other site 146891003803 putative ATP binding site [chemical binding]; other site 146891003804 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 146891003805 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 146891003806 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 146891003807 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 146891003808 putative active site [active] 146891003809 catalytic triad [active] 146891003810 putative dimer interface [polypeptide binding]; other site 146891003811 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 146891003812 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 146891003813 superoxide dismutase, Ni; Region: sodN; TIGR02753 146891003814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891003815 Catalytic site [active] 146891003816 High-affinity nickel-transport protein; Region: NicO; cl00964 146891003817 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 146891003818 active site 146891003819 ribulose/triose binding site [chemical binding]; other site 146891003820 phosphate binding site [ion binding]; other site 146891003821 substrate (anthranilate) binding pocket [chemical binding]; other site 146891003822 product (indole) binding pocket [chemical binding]; other site 146891003823 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 146891003824 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 146891003825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 146891003826 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 146891003827 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 146891003828 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 146891003829 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 146891003830 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 146891003831 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 146891003832 hinge; other site 146891003833 active site 146891003834 acetylornithine aminotransferase; Provisional; Region: PRK02627 146891003835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891003836 inhibitor-cofactor binding pocket; inhibition site 146891003837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891003838 catalytic residue [active] 146891003839 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 146891003840 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 146891003841 FAD binding domain; Region: FAD_binding_4; pfam01565 146891003842 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 146891003843 Amidohydrolase; Region: Amidohydro_4; pfam13147 146891003844 active site 146891003845 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 146891003846 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 146891003847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003848 FeS/SAM binding site; other site 146891003849 TRAM domain; Region: TRAM; pfam01938 146891003850 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 146891003851 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 146891003852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 146891003853 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 146891003854 cell division protein FtsZ; Validated; Region: PRK09330 146891003855 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 146891003856 nucleotide binding site [chemical binding]; other site 146891003857 SulA interaction site; other site 146891003858 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 146891003859 oligomerization interface [polypeptide binding]; other site 146891003860 active site 146891003861 metal binding site [ion binding]; metal-binding site 146891003862 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 146891003863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003864 FeS/SAM binding site; other site 146891003865 HemN C-terminal domain; Region: HemN_C; pfam06969 146891003866 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 146891003867 putative active site [active] 146891003868 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 146891003869 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891003870 oligomer interface [polypeptide binding]; other site 146891003871 active site residues [active] 146891003872 Clp protease; Region: CLP_protease; pfam00574 146891003873 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891003874 oligomer interface [polypeptide binding]; other site 146891003875 active site residues [active] 146891003876 ketol-acid reductoisomerase; Provisional; Region: PRK05479 146891003877 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 146891003878 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 146891003879 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 146891003880 light-harvesting-like protein 3; Provisional; Region: PLN00014 146891003881 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 146891003882 IHF dimer interface [polypeptide binding]; other site 146891003883 IHF - DNA interface [nucleotide binding]; other site 146891003884 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 146891003885 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 146891003886 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 146891003887 active site 146891003888 catalytic site [active] 146891003889 MFS/sugar transport protein; Region: MFS_2; pfam13347 146891003890 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 146891003891 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 146891003892 Permease; Region: Permease; pfam02405 146891003893 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 146891003894 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 146891003895 membrane protein; Provisional; Region: PRK14419 146891003896 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 146891003897 active site 146891003898 dimer interface [polypeptide binding]; other site 146891003899 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 146891003900 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 146891003901 active site 146891003902 HIGH motif; other site 146891003903 dimer interface [polypeptide binding]; other site 146891003904 KMSKS motif; other site 146891003905 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 146891003906 multifunctional aminopeptidase A; Provisional; Region: PRK00913 146891003907 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 146891003908 interface (dimer of trimers) [polypeptide binding]; other site 146891003909 Substrate-binding/catalytic site; other site 146891003910 Zn-binding sites [ion binding]; other site 146891003911 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 146891003912 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 146891003913 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 146891003914 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 146891003915 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 146891003916 active site 146891003917 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 146891003918 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 146891003919 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 146891003920 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 146891003921 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 146891003922 Surface antigen; Region: Bac_surface_Ag; pfam01103 146891003923 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 146891003924 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 146891003925 ATP binding site [chemical binding]; other site 146891003926 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 146891003927 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 146891003928 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 146891003929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 146891003930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 146891003931 dimerization interface [polypeptide binding]; other site 146891003932 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 146891003933 PAS domain; Region: PAS; smart00091 146891003934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891003935 dimer interface [polypeptide binding]; other site 146891003936 phosphorylation site [posttranslational modification] 146891003937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891003938 ATP binding site [chemical binding]; other site 146891003939 Mg2+ binding site [ion binding]; other site 146891003940 G-X-G motif; other site 146891003941 circadian clock protein KaiC; Reviewed; Region: PRK09302 146891003942 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 146891003943 Walker A motif; other site 146891003944 ATP binding site [chemical binding]; other site 146891003945 Walker B motif; other site 146891003946 recA bacterial DNA recombination protein; Region: RecA; cl17211 146891003947 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 146891003948 Walker A motif; other site 146891003949 ATP binding site [chemical binding]; other site 146891003950 Walker B motif; other site 146891003951 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 146891003952 tetramer interface [polypeptide binding]; other site 146891003953 dimer interface [polypeptide binding]; other site 146891003954 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 146891003955 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 146891003956 Methyltransferase domain; Region: Methyltransf_12; pfam08242 146891003957 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 146891003958 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 146891003959 RNA binding site [nucleotide binding]; other site 146891003960 active site 146891003961 Stage II sporulation protein; Region: SpoIID; pfam08486 146891003962 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 146891003963 ribonuclease Z; Region: RNase_Z; TIGR02651 146891003964 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 146891003965 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891003966 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 146891003967 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891003968 catalytic loop [active] 146891003969 iron binding site [ion binding]; other site 146891003970 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 146891003971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003972 S-adenosylmethionine binding site [chemical binding]; other site 146891003973 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 146891003974 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 146891003975 ligand binding site [chemical binding]; other site 146891003976 NAD binding site [chemical binding]; other site 146891003977 dimerization interface [polypeptide binding]; other site 146891003978 catalytic site [active] 146891003979 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 146891003980 putative L-serine binding site [chemical binding]; other site 146891003981 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 146891003982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891003983 RNA binding surface [nucleotide binding]; other site 146891003984 Phospholipid methyltransferase; Region: PEMT; cl17370 146891003985 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 146891003986 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 146891003987 DoxX; Region: DoxX; pfam07681 146891003988 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891003989 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 146891003990 nucleotide binding pocket [chemical binding]; other site 146891003991 K-X-D-G motif; other site 146891003992 catalytic site [active] 146891003993 short chain dehydrogenase; Provisional; Region: PRK06197 146891003994 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 146891003995 putative NAD(P) binding site [chemical binding]; other site 146891003996 active site 146891003997 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 146891003998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 146891003999 Pirin-related protein [General function prediction only]; Region: COG1741 146891004000 Pirin; Region: Pirin; pfam02678 146891004001 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 146891004002 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 146891004003 GAF domain; Region: GAF; pfam01590 146891004004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 146891004005 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 146891004006 flavoprotein, HI0933 family; Region: TIGR00275 146891004007 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 146891004008 Protein of unknown function (DUF805); Region: DUF805; pfam05656 146891004009 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891004010 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 146891004011 putative di-iron ligands [ion binding]; other site 146891004012 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 146891004013 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 146891004014 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891004015 putative di-iron ligands [ion binding]; other site 146891004016 Protein of unknown function (DUF938); Region: DUF938; pfam06080 146891004017 putative high light inducible protein; Region: PHA02337 146891004018 putative high light inducible protein; Region: PHA02337 146891004019 putative high light inducible protein; Region: PHA02337 146891004020 Predicted permeases [General function prediction only]; Region: COG0795 146891004021 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 146891004022 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 146891004023 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 146891004024 DoxX; Region: DoxX; pfam07681 146891004025 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 146891004026 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 146891004027 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 146891004028 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 146891004029 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891004030 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891004031 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 146891004032 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891004033 EVE domain; Region: EVE; cl00728 146891004034 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 146891004035 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 146891004036 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 146891004037 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 146891004038 nucleotide binding site [chemical binding]; other site 146891004039 putative NEF/HSP70 interaction site [polypeptide binding]; other site 146891004040 SBD interface [polypeptide binding]; other site 146891004041 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 146891004042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 146891004043 active site 146891004044 phosphoglyceromutase; Provisional; Region: PRK05434 146891004045 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 146891004046 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 146891004047 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 146891004048 ring oligomerisation interface [polypeptide binding]; other site 146891004049 ATP/Mg binding site [chemical binding]; other site 146891004050 stacking interactions; other site 146891004051 hinge regions; other site 146891004052 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 146891004053 oligomerisation interface [polypeptide binding]; other site 146891004054 mobile loop; other site 146891004055 roof hairpin; other site 146891004056 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 146891004057 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 146891004058 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 146891004059 alpha subunit interaction interface [polypeptide binding]; other site 146891004060 Walker A motif; other site 146891004061 ATP binding site [chemical binding]; other site 146891004062 Walker B motif; other site 146891004063 inhibitor binding site; inhibition site 146891004064 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 146891004065 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 146891004066 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 146891004067 gamma subunit interface [polypeptide binding]; other site 146891004068 epsilon subunit interface [polypeptide binding]; other site 146891004069 LBP interface [polypeptide binding]; other site 146891004070 hypothetical protein; Provisional; Region: PRK02724 146891004071 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 146891004072 proline aminopeptidase P II; Provisional; Region: PRK10879 146891004073 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 146891004074 active site 146891004075 Domain of unknown function DUF21; Region: DUF21; pfam01595 146891004076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 146891004077 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 146891004078 G1 box; other site 146891004079 GTP/Mg2+ binding site [chemical binding]; other site 146891004080 Dynamin family; Region: Dynamin_N; pfam00350 146891004081 Switch I region; other site 146891004082 G2 box; other site 146891004083 Switch II region; other site 146891004084 G3 box; other site 146891004085 G4 box; other site 146891004086 Domain of unknown function (DUF697); Region: DUF697; pfam05128 146891004087 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 146891004088 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 146891004089 active site 146891004090 (T/H)XGH motif; other site 146891004091 NAD synthetase; Provisional; Region: PRK13981 146891004092 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 146891004093 multimer interface [polypeptide binding]; other site 146891004094 active site 146891004095 catalytic triad [active] 146891004096 protein interface 1 [polypeptide binding]; other site 146891004097 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 146891004098 homodimer interface [polypeptide binding]; other site 146891004099 NAD binding pocket [chemical binding]; other site 146891004100 ATP binding pocket [chemical binding]; other site 146891004101 Mg binding site [ion binding]; other site 146891004102 active-site loop [active] 146891004103 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 146891004104 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 146891004105 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891004106 catalytic loop [active] 146891004107 iron binding site [ion binding]; other site 146891004108 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 146891004109 core domain interface [polypeptide binding]; other site 146891004110 delta subunit interface [polypeptide binding]; other site 146891004111 epsilon subunit interface [polypeptide binding]; other site 146891004112 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 146891004113 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 146891004114 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 146891004115 beta subunit interaction interface [polypeptide binding]; other site 146891004116 Walker A motif; other site 146891004117 ATP binding site [chemical binding]; other site 146891004118 Walker B motif; other site 146891004119 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 146891004120 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 146891004121 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 146891004122 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 146891004123 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 146891004124 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 146891004125 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 146891004126 ATP synthase CF0 C subunit; Region: atpH; CHL00061 146891004127 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 146891004128 ATP synthase CF0 A subunit; Region: atpI; CHL00046 146891004129 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 146891004130 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 146891004131 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 146891004132 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 146891004133 ResB-like family; Region: ResB; pfam05140 146891004134 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 146891004135 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 146891004136 Nitrogen regulatory protein P-II; Region: P-II; smart00938 146891004137 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 146891004138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891004139 RNA binding surface [nucleotide binding]; other site 146891004140 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 146891004141 adenylosuccinate lyase; Provisional; Region: PRK07380 146891004142 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 146891004143 tetramer interface [polypeptide binding]; other site 146891004144 active site 146891004145 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 146891004146 fumarate hydratase; Reviewed; Region: fumC; PRK00485 146891004147 Class II fumarases; Region: Fumarase_classII; cd01362 146891004148 active site 146891004149 tetramer interface [polypeptide binding]; other site 146891004150 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 146891004151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891004152 ATP binding site [chemical binding]; other site 146891004153 putative Mg++ binding site [ion binding]; other site 146891004154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891004155 nucleotide binding region [chemical binding]; other site 146891004156 ATP-binding site [chemical binding]; other site 146891004157 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 146891004158 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 146891004159 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 146891004160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891004161 catalytic residue [active] 146891004162 variable surface protein Vir18; Provisional; Region: PTZ00233 146891004163 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 146891004164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891004165 S-adenosylmethionine binding site [chemical binding]; other site 146891004166 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 146891004167 AAA domain; Region: AAA_26; pfam13500 146891004168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891004169 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 146891004170 inhibitor-cofactor binding pocket; inhibition site 146891004171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004172 catalytic residue [active] 146891004173 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 146891004174 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891004175 HSP70 interaction site [polypeptide binding]; other site 146891004176 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 146891004177 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 146891004178 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 146891004179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 146891004180 active site 146891004181 catalytic tetrad [active] 146891004182 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 146891004183 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 146891004184 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 146891004185 HEAT repeats; Region: HEAT_2; pfam13646 146891004186 HEAT repeats; Region: HEAT_2; pfam13646 146891004187 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 146891004188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891004189 FeS/SAM binding site; other site 146891004190 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 146891004191 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 146891004192 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 146891004193 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 146891004194 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 146891004195 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 146891004196 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 146891004197 DNA binding site [nucleotide binding] 146891004198 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 146891004199 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 146891004200 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 146891004201 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 146891004202 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 146891004203 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 146891004204 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 146891004205 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 146891004206 RPB1 interaction site [polypeptide binding]; other site 146891004207 RPB10 interaction site [polypeptide binding]; other site 146891004208 RPB11 interaction site [polypeptide binding]; other site 146891004209 RPB3 interaction site [polypeptide binding]; other site 146891004210 RPB12 interaction site [polypeptide binding]; other site 146891004211 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 146891004212 active site 146891004213 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 146891004214 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 146891004215 histidinol dehydrogenase; Region: hisD; TIGR00069 146891004216 NAD binding site [chemical binding]; other site 146891004217 dimerization interface [polypeptide binding]; other site 146891004218 product binding site; other site 146891004219 substrate binding site [chemical binding]; other site 146891004220 zinc binding site [ion binding]; other site 146891004221 catalytic residues [active] 146891004222 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 146891004223 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891004224 active site 146891004225 dimer interface [polypeptide binding]; other site 146891004226 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 146891004227 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 146891004228 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 146891004229 protein binding site [polypeptide binding]; other site 146891004230 hypothetical protein; Provisional; Region: PRK14646 146891004231 ribosome maturation protein RimP; Reviewed; Region: PRK00092 146891004232 heptamer interface [polypeptide binding]; other site 146891004233 Sm1 motif; other site 146891004234 hexamer interface [polypeptide binding]; other site 146891004235 RNA binding site [nucleotide binding]; other site 146891004236 Sm2 motif; other site 146891004237 NusA N-terminal domain; Region: NusA_N; pfam08529 146891004238 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 146891004239 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 146891004240 RNA binding site [nucleotide binding]; other site 146891004241 homodimer interface [polypeptide binding]; other site 146891004242 NusA-like KH domain; Region: KH_5; pfam13184 146891004243 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 146891004244 G-X-X-G motif; other site 146891004245 Protein of unknown function (DUF448); Region: DUF448; pfam04296 146891004246 translation initiation factor IF-2; Region: IF-2; TIGR00487 146891004247 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 146891004248 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 146891004249 G1 box; other site 146891004250 putative GEF interaction site [polypeptide binding]; other site 146891004251 GTP/Mg2+ binding site [chemical binding]; other site 146891004252 Switch I region; other site 146891004253 G2 box; other site 146891004254 G3 box; other site 146891004255 Switch II region; other site 146891004256 G4 box; other site 146891004257 G5 box; other site 146891004258 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 146891004259 Translation-initiation factor 2; Region: IF-2; pfam11987 146891004260 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 146891004261 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 146891004262 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 146891004263 B12 binding site [chemical binding]; other site 146891004264 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 146891004265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 146891004266 FeS/SAM binding site; other site 146891004267 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 146891004268 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 146891004269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891004270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004271 homodimer interface [polypeptide binding]; other site 146891004272 catalytic residue [active] 146891004273 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 146891004274 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 146891004275 homodimer interface [polypeptide binding]; other site 146891004276 oligonucleotide binding site [chemical binding]; other site 146891004277 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 146891004278 RNA/DNA hybrid binding site [nucleotide binding]; other site 146891004279 active site 146891004280 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 146891004281 prephenate dehydratase; Provisional; Region: PRK11898 146891004282 Prephenate dehydratase; Region: PDT; pfam00800 146891004283 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 146891004284 putative L-Phe binding site [chemical binding]; other site 146891004285 Methyltransferase domain; Region: Methyltransf_31; pfam13847 146891004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891004287 S-adenosylmethionine binding site [chemical binding]; other site 146891004288 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 146891004289 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 146891004290 elongation factor Tu; Reviewed; Region: PRK00049 146891004291 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 146891004292 G1 box; other site 146891004293 GEF interaction site [polypeptide binding]; other site 146891004294 GTP/Mg2+ binding site [chemical binding]; other site 146891004295 Switch I region; other site 146891004296 G2 box; other site 146891004297 G3 box; other site 146891004298 Switch II region; other site 146891004299 G4 box; other site 146891004300 G5 box; other site 146891004301 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 146891004302 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 146891004303 Antibiotic Binding Site [chemical binding]; other site 146891004304 elongation factor G; Reviewed; Region: PRK00007 146891004305 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 146891004306 G1 box; other site 146891004307 putative GEF interaction site [polypeptide binding]; other site 146891004308 GTP/Mg2+ binding site [chemical binding]; other site 146891004309 Switch I region; other site 146891004310 G2 box; other site 146891004311 G3 box; other site 146891004312 Switch II region; other site 146891004313 G4 box; other site 146891004314 G5 box; other site 146891004315 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 146891004316 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 146891004317 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 146891004318 30S ribosomal protein S7; Validated; Region: PRK05302 146891004319 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 146891004320 S17 interaction site [polypeptide binding]; other site 146891004321 S8 interaction site; other site 146891004322 16S rRNA interaction site [nucleotide binding]; other site 146891004323 streptomycin interaction site [chemical binding]; other site 146891004324 23S rRNA interaction site [nucleotide binding]; other site 146891004325 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 146891004326 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 146891004327 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 146891004328 active site 146891004329 dimer interface [polypeptide binding]; other site 146891004330 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 146891004331 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 146891004332 active site 146891004333 FMN binding site [chemical binding]; other site 146891004334 substrate binding site [chemical binding]; other site 146891004335 3Fe-4S cluster binding site [ion binding]; other site 146891004336 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 146891004337 domain interface; other site 146891004338 YCII-related domain; Region: YCII; cl00999 146891004339 lipoyl synthase; Provisional; Region: PRK05481 146891004340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891004341 FeS/SAM binding site; other site 146891004342 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 146891004343 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 146891004344 catalytic residues [active] 146891004345 catalytic nucleophile [active] 146891004346 Presynaptic Site I dimer interface [polypeptide binding]; other site 146891004347 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 146891004348 Synaptic Flat tetramer interface [polypeptide binding]; other site 146891004349 Synaptic Site I dimer interface [polypeptide binding]; other site 146891004350 DNA binding site [nucleotide binding] 146891004351 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 146891004352 NlpC/P60 family; Region: NLPC_P60; pfam00877 146891004353 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 146891004354 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 146891004355 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 146891004356 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 146891004357 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 146891004358 Ligand binding site; other site 146891004359 Putative Catalytic site; other site 146891004360 DXD motif; other site 146891004361 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 146891004362 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 146891004363 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 146891004364 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 146891004365 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 146891004366 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 146891004367 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 146891004368 active site 146891004369 SAM binding site [chemical binding]; other site 146891004370 homodimer interface [polypeptide binding]; other site 146891004371 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 146891004372 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 146891004373 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 146891004374 alanine racemase; Reviewed; Region: alr; PRK00053 146891004375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 146891004376 active site 146891004377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891004378 dimer interface [polypeptide binding]; other site 146891004379 substrate binding site [chemical binding]; other site 146891004380 catalytic residues [active] 146891004381 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 146891004382 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 146891004383 active site 146891004384 peptide chain release factor 1; Validated; Region: prfA; PRK00591 146891004385 This domain is found in peptide chain release factors; Region: PCRF; smart00937 146891004386 RF-1 domain; Region: RF-1; pfam00472 146891004387 ribosomal protein L31; Validated; Region: rpl31; CHL00136 146891004388 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 146891004389 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 146891004390 23S rRNA interface [nucleotide binding]; other site 146891004391 L3 interface [polypeptide binding]; other site 146891004392 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 146891004393 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 146891004394 dimerization interface 3.5A [polypeptide binding]; other site 146891004395 active site 146891004396 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 146891004397 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 146891004398 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 146891004399 alphaNTD homodimer interface [polypeptide binding]; other site 146891004400 alphaNTD - beta interaction site [polypeptide binding]; other site 146891004401 alphaNTD - beta' interaction site [polypeptide binding]; other site 146891004402 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 146891004403 30S ribosomal protein S11; Validated; Region: PRK05309 146891004404 ribosomal protein S13; Validated; Region: rps13; CHL00137 146891004405 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 146891004406 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 146891004407 adenylate kinase; Reviewed; Region: adk; PRK00279 146891004408 AMP-binding site [chemical binding]; other site 146891004409 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 146891004410 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 146891004411 SecY translocase; Region: SecY; pfam00344 146891004412 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 146891004413 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 146891004414 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 146891004415 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 146891004416 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 146891004417 5S rRNA interface [nucleotide binding]; other site 146891004418 L27 interface [polypeptide binding]; other site 146891004419 23S rRNA interface [nucleotide binding]; other site 146891004420 L5 interface [polypeptide binding]; other site 146891004421 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 146891004422 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 146891004423 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 146891004424 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 146891004425 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 146891004426 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 146891004427 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 146891004428 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 146891004429 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 146891004430 RNA binding site [nucleotide binding]; other site 146891004431 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 146891004432 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 146891004433 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 146891004434 23S rRNA interface [nucleotide binding]; other site 146891004435 putative translocon interaction site; other site 146891004436 signal recognition particle (SRP54) interaction site; other site 146891004437 L23 interface [polypeptide binding]; other site 146891004438 trigger factor interaction site; other site 146891004439 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 146891004440 23S rRNA interface [nucleotide binding]; other site 146891004441 5S rRNA interface [nucleotide binding]; other site 146891004442 putative antibiotic binding site [chemical binding]; other site 146891004443 L25 interface [polypeptide binding]; other site 146891004444 L27 interface [polypeptide binding]; other site 146891004445 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 146891004446 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 146891004447 G-X-X-G motif; other site 146891004448 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 146891004449 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 146891004450 putative translocon binding site; other site 146891004451 protein-rRNA interface [nucleotide binding]; other site 146891004452 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 146891004453 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 146891004454 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 146891004455 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 146891004456 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 146891004457 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 146891004458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 146891004459 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 146891004460 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 146891004461 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 146891004462 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 146891004463 recombinase A; Provisional; Region: recA; PRK09354 146891004464 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 146891004465 hexamer interface [polypeptide binding]; other site 146891004466 Walker A motif; other site 146891004467 ATP binding site [chemical binding]; other site 146891004468 Walker B motif; other site 146891004469 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891004470 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 146891004471 arogenate dehydrogenase; Reviewed; Region: PRK07417 146891004472 prephenate dehydrogenase; Validated; Region: PRK08507 146891004473 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 146891004474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 146891004475 Fructosamine kinase; Region: Fructosamin_kin; cl17579 146891004476 Phosphotransferase enzyme family; Region: APH; pfam01636 146891004477 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 146891004478 hypothetical protein; Validated; Region: PRK07411 146891004479 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 146891004480 ATP binding site [chemical binding]; other site 146891004481 substrate interface [chemical binding]; other site 146891004482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 146891004483 active site residue [active] 146891004484 hypothetical protein; Validated; Region: PRK07413 146891004485 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 146891004486 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 146891004487 Walker A motif; other site 146891004488 homodimer interface [polypeptide binding]; other site 146891004489 ATP binding site [chemical binding]; other site 146891004490 hydroxycobalamin binding site [chemical binding]; other site 146891004491 Walker B motif; other site 146891004492 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 146891004493 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 146891004494 Ligand Binding Site [chemical binding]; other site 146891004495 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 146891004496 recombination protein F; Reviewed; Region: recF; PRK00064 146891004497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891004498 Q-loop/lid; other site 146891004499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891004500 ABC transporter signature motif; other site 146891004501 Walker B; other site 146891004502 D-loop; other site 146891004503 H-loop/switch region; other site 146891004504 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 146891004505 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 146891004506 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 146891004507 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 146891004508 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 146891004509 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 146891004510 PsaD; Region: PsaD; pfam02531 146891004511 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 146891004512 Domain of unknown function DUF59; Region: DUF59; pfam01883 146891004513 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 146891004514 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 146891004515 Walker A motif; other site 146891004516 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 146891004517 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 146891004518 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 146891004519 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 146891004520 catalytic site [active] 146891004521 putative active site [active] 146891004522 putative substrate binding site [chemical binding]; other site 146891004523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 146891004524 conserved hypothetical protein; Region: TIGR03492 146891004525 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891004526 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 146891004527 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 146891004528 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 146891004529 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 146891004530 dimerization interface [polypeptide binding]; other site 146891004531 putative ATP binding site [chemical binding]; other site 146891004532 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 146891004533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891004534 active site 146891004535 nucleotide binding site [chemical binding]; other site 146891004536 HIGH motif; other site 146891004537 KMSKS motif; other site 146891004538 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 146891004539 CMP-binding site; other site 146891004540 The sites determining sugar specificity; other site 146891004541 Low molecular weight phosphatase family; Region: LMWPc; cd00115 146891004542 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 146891004543 active site 146891004544 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 146891004545 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 146891004546 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 146891004547 heme binding pocket [chemical binding]; other site 146891004548 heme ligand [chemical binding]; other site 146891004549 isocitrate dehydrogenase; Validated; Region: PRK07362 146891004550 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 146891004551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 146891004552 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 146891004553 active site 146891004554 catalytic residues [active] 146891004555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 146891004556 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 146891004557 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 146891004558 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 146891004559 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 146891004560 homodimer interface [polypeptide binding]; other site 146891004561 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 146891004562 active site pocket [active] 146891004563 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 146891004564 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 146891004565 dimerization interface [polypeptide binding]; other site 146891004566 active site 146891004567 metal binding site [ion binding]; metal-binding site 146891004568 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 146891004569 dsRNA binding site [nucleotide binding]; other site 146891004570 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 146891004571 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 146891004572 RimM N-terminal domain; Region: RimM; pfam01782 146891004573 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 146891004574 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 146891004575 glutaminase active site [active] 146891004576 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 146891004577 dimer interface [polypeptide binding]; other site 146891004578 active site 146891004579 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 146891004580 dimer interface [polypeptide binding]; other site 146891004581 active site 146891004582 photosystem I subunit VII; Region: psaC; CHL00065 146891004583 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 146891004584 acyl carrier protein; Provisional; Region: acpP; PRK00982 146891004585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 146891004586 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 146891004587 dimer interface [polypeptide binding]; other site 146891004588 active site 146891004589 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 146891004590 transketolase; Region: PLN02790 146891004591 TPP-binding site [chemical binding]; other site 146891004592 dimer interface [polypeptide binding]; other site 146891004593 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891004594 PYR/PP interface [polypeptide binding]; other site 146891004595 dimer interface [polypeptide binding]; other site 146891004596 TPP binding site [chemical binding]; other site 146891004597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891004598 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 146891004599 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 146891004600 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 146891004601 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 146891004602 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 146891004603 metal binding site [ion binding]; metal-binding site 146891004604 dimer interface [polypeptide binding]; other site 146891004605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004606 binding surface 146891004607 TPR motif; other site 146891004608 TPR repeat; Region: TPR_11; pfam13414 146891004609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004610 binding surface 146891004611 TPR motif; other site 146891004612 TPR repeat; Region: TPR_11; pfam13414 146891004613 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 146891004614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004615 Walker A motif; other site 146891004616 ATP binding site [chemical binding]; other site 146891004617 Walker B motif; other site 146891004618 arginine finger; other site 146891004619 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 146891004620 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 146891004621 SmpB-tmRNA interface; other site 146891004622 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 146891004623 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 146891004624 dimer interface [polypeptide binding]; other site 146891004625 putative anticodon binding site; other site 146891004626 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 146891004627 motif 1; other site 146891004628 active site 146891004629 motif 2; other site 146891004630 motif 3; other site 146891004631 Ycf27; Reviewed; Region: orf27; CHL00148 146891004632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891004633 active site 146891004634 phosphorylation site [posttranslational modification] 146891004635 intermolecular recognition site; other site 146891004636 dimerization interface [polypeptide binding]; other site 146891004637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891004638 DNA binding site [nucleotide binding] 146891004639 rod shape-determining protein MreC; Provisional; Region: PRK13922 146891004640 rod shape-determining protein MreC; Region: MreC; pfam04085 146891004641 rod shape-determining protein MreB; Provisional; Region: PRK13927 146891004642 MreB and similar proteins; Region: MreB_like; cd10225 146891004643 nucleotide binding site [chemical binding]; other site 146891004644 Mg binding site [ion binding]; other site 146891004645 putative protofilament interaction site [polypeptide binding]; other site 146891004646 RodZ interaction site [polypeptide binding]; other site 146891004647 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 146891004648 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 146891004649 dimer interface [polypeptide binding]; other site 146891004650 ssDNA binding site [nucleotide binding]; other site 146891004651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891004652 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 146891004653 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 146891004654 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 146891004655 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 146891004656 homotetramer interface [polypeptide binding]; other site 146891004657 ligand binding site [chemical binding]; other site 146891004658 catalytic site [active] 146891004659 NAD binding site [chemical binding]; other site 146891004660 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 146891004661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891004662 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 146891004663 putative substrate binding site [chemical binding]; other site 146891004664 putative ATP binding site [chemical binding]; other site 146891004665 hydrolase, alpha/beta fold family protein; Region: PLN02824 146891004666 Serine hydrolase; Region: Ser_hydrolase; cl17834 146891004667 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891004668 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891004669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891004670 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891004671 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 146891004672 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 146891004673 MgtE intracellular N domain; Region: MgtE_N; smart00924 146891004674 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 146891004675 Divalent cation transporter; Region: MgtE; pfam01769 146891004676 CrcB-like protein; Region: CRCB; pfam02537 146891004677 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 146891004678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891004679 ATP binding site [chemical binding]; other site 146891004680 Mg2+ binding site [ion binding]; other site 146891004681 G-X-G motif; other site 146891004682 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 146891004683 anchoring element; other site 146891004684 dimer interface [polypeptide binding]; other site 146891004685 ATP binding site [chemical binding]; other site 146891004686 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 146891004687 active site 146891004688 putative metal-binding site [ion binding]; other site 146891004689 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 146891004690 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 146891004691 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 146891004692 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 146891004693 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 146891004694 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 146891004695 Predicted transcriptional regulators [Transcription]; Region: COG1725 146891004696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 146891004697 DNA-binding site [nucleotide binding]; DNA binding site 146891004698 serine O-acetyltransferase; Region: cysE; TIGR01172 146891004699 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 146891004700 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 146891004701 trimer interface [polypeptide binding]; other site 146891004702 active site 146891004703 substrate binding site [chemical binding]; other site 146891004704 CoA binding site [chemical binding]; other site 146891004705 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 146891004706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891004707 ATP binding site [chemical binding]; other site 146891004708 putative Mg++ binding site [ion binding]; other site 146891004709 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 146891004710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891004711 Coenzyme A binding pocket [chemical binding]; other site 146891004712 SnoaL-like domain; Region: SnoaL_2; pfam12680 146891004713 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 146891004714 homopentamer interface [polypeptide binding]; other site 146891004715 active site 146891004716 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 146891004717 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 146891004718 MutS domain I; Region: MutS_I; pfam01624 146891004719 MutS domain II; Region: MutS_II; pfam05188 146891004720 MutS domain III; Region: MutS_III; pfam05192 146891004721 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 146891004722 Walker A/P-loop; other site 146891004723 ATP binding site [chemical binding]; other site 146891004724 Q-loop/lid; other site 146891004725 ABC transporter signature motif; other site 146891004726 Walker B; other site 146891004727 D-loop; other site 146891004728 H-loop/switch region; other site 146891004729 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 146891004730 Precorrin-8X methylmutase; Region: CbiC; pfam02570 146891004731 DNA polymerase III subunit delta; Validated; Region: PRK07452 146891004732 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 146891004733 aspartate kinase; Provisional; Region: PRK07431 146891004734 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 146891004735 putative nucleotide binding site [chemical binding]; other site 146891004736 putative catalytic residues [active] 146891004737 putative Mg ion binding site [ion binding]; other site 146891004738 putative aspartate binding site [chemical binding]; other site 146891004739 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 146891004740 putative allosteric regulatory site; other site 146891004741 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 146891004742 putative allosteric regulatory residue; other site 146891004743 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 146891004744 putative allosteric regulatory site; other site 146891004745 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 146891004746 putative allosteric regulatory residue; other site 146891004747 excinuclease ABC subunit B; Provisional; Region: PRK05298 146891004748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891004749 ATP binding site [chemical binding]; other site 146891004750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891004751 nucleotide binding region [chemical binding]; other site 146891004752 ATP-binding site [chemical binding]; other site 146891004753 Ultra-violet resistance protein B; Region: UvrB; pfam12344 146891004754 UvrB/uvrC motif; Region: UVR; pfam02151 146891004755 Protein of unknown function (DUF561); Region: DUF561; pfam04481 146891004756 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 146891004757 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 146891004758 Ligand Binding Site [chemical binding]; other site 146891004759 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 146891004760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 146891004761 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 146891004762 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 146891004763 dihydrodipicolinate synthase; Region: dapA; TIGR00674 146891004764 dimer interface [polypeptide binding]; other site 146891004765 active site 146891004766 catalytic residue [active] 146891004767 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 146891004768 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 146891004769 trigger factor; Provisional; Region: tig; PRK01490 146891004770 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 146891004771 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 146891004772 Clp protease; Region: CLP_protease; pfam00574 146891004773 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891004774 oligomer interface [polypeptide binding]; other site 146891004775 active site residues [active] 146891004776 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 146891004777 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 146891004778 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 146891004779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004780 Walker A motif; other site 146891004781 ATP binding site [chemical binding]; other site 146891004782 Walker B motif; other site 146891004783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 146891004784 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 146891004785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004786 Walker A motif; other site 146891004787 ATP binding site [chemical binding]; other site 146891004788 Walker B motif; other site 146891004789 arginine finger; other site 146891004790 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 146891004791 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 146891004792 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 146891004793 DXD motif; other site 146891004794 Sporulation related domain; Region: SPOR; cl10051 146891004795 Stage II sporulation protein; Region: SpoIID; pfam08486 146891004796 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 146891004797 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 146891004798 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 146891004799 23S rRNA binding site [nucleotide binding]; other site 146891004800 L21 binding site [polypeptide binding]; other site 146891004801 L13 binding site [polypeptide binding]; other site 146891004802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004803 binding surface 146891004804 TPR motif; other site 146891004805 TPR repeat; Region: TPR_11; pfam13414 146891004806 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 146891004807 ThiS interaction site; other site 146891004808 putative active site [active] 146891004809 tetramer interface [polypeptide binding]; other site 146891004810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004811 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891004812 NAD(P) binding site [chemical binding]; other site 146891004813 active site 146891004814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891004815 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 146891004816 glycine dehydrogenase; Provisional; Region: PRK05367 146891004817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891004818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891004819 catalytic residue [active] 146891004820 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 146891004821 tetramer interface [polypeptide binding]; other site 146891004822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004823 catalytic residue [active] 146891004824 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 146891004825 lipoyl attachment site [posttranslational modification]; other site 146891004826 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 146891004827 Aluminium resistance protein; Region: Alum_res; pfam06838 146891004828 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 146891004829 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891004830 Di-iron ligands [ion binding]; other site 146891004831 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 146891004832 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 146891004833 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 146891004834 replicative DNA helicase; Region: DnaB; TIGR00665 146891004835 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 146891004836 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 146891004837 Walker A motif; other site 146891004838 ATP binding site [chemical binding]; other site 146891004839 Walker B motif; other site 146891004840 DNA binding loops [nucleotide binding] 146891004841 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 146891004842 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 146891004843 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 146891004844 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 146891004845 Protein of unknown function (DUF98); Region: DUF98; pfam01947 146891004846 SprT-like family; Region: SprT-like; pfam10263 146891004847 SprT homologues; Region: SprT; cl01182 146891004848 DNA ligase; Provisional; Region: 30; PHA02587 146891004849 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 146891004850 active site 146891004851 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 146891004852 DNA binding site [nucleotide binding] 146891004853 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 146891004854 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 146891004855 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891004856 active site 146891004857 HIGH motif; other site 146891004858 nucleotide binding site [chemical binding]; other site 146891004859 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 146891004860 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 146891004861 active site 146891004862 KMSKS motif; other site 146891004863 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 146891004864 tRNA binding surface [nucleotide binding]; other site 146891004865 anticodon binding site; other site 146891004866 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 146891004867 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 146891004868 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 146891004869 homodimer interface [polypeptide binding]; other site 146891004870 metal binding site [ion binding]; metal-binding site 146891004871 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 146891004872 homodimer interface [polypeptide binding]; other site 146891004873 active site 146891004874 putative chemical substrate binding site [chemical binding]; other site 146891004875 metal binding site [ion binding]; metal-binding site 146891004876 spermidine synthase; Provisional; Region: PRK00811 146891004877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891004878 S-adenosylmethionine binding site [chemical binding]; other site 146891004879 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 146891004880 agmatinase; Region: agmatinase; TIGR01230 146891004881 putative active site [active] 146891004882 Mn binding site [ion binding]; other site 146891004883 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 146891004884 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 146891004885 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 146891004886 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 146891004887 dimer interface [polypeptide binding]; other site 146891004888 anticodon binding site; other site 146891004889 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 146891004890 motif 1; other site 146891004891 dimer interface [polypeptide binding]; other site 146891004892 active site 146891004893 motif 2; other site 146891004894 GAD domain; Region: GAD; pfam02938 146891004895 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 146891004896 active site 146891004897 motif 3; other site 146891004898 CTP synthetase; Validated; Region: pyrG; PRK05380 146891004899 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 146891004900 Catalytic site [active] 146891004901 active site 146891004902 UTP binding site [chemical binding]; other site 146891004903 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 146891004904 active site 146891004905 putative oxyanion hole; other site 146891004906 catalytic triad [active] 146891004907 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 146891004908 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 146891004909 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 146891004910 Ligand Binding Site [chemical binding]; other site 146891004911 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 146891004912 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 146891004913 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 146891004914 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 146891004915 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 146891004916 homodimer interface [polypeptide binding]; other site 146891004917 substrate-cofactor binding pocket; other site 146891004918 Aminotransferase class IV; Region: Aminotran_4; pfam01063 146891004919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004920 catalytic residue [active] 146891004921 diphthine synthase; Region: dph5; TIGR00522 146891004922 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 146891004923 active site 146891004924 SAM binding site [chemical binding]; other site 146891004925 homodimer interface [polypeptide binding]; other site 146891004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 146891004927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 146891004928 putative substrate translocation pore; other site 146891004929 polyphosphate kinase; Provisional; Region: PRK05443 146891004930 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 146891004931 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 146891004932 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 146891004933 putative domain interface [polypeptide binding]; other site 146891004934 putative active site [active] 146891004935 catalytic site [active] 146891004936 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 146891004937 putative domain interface [polypeptide binding]; other site 146891004938 putative active site [active] 146891004939 catalytic site [active] 146891004940 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891004941 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891004942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891004943 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891004944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891004945 DNA binding residues [nucleotide binding] 146891004946 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 146891004947 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 146891004948 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 146891004949 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 146891004950 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 146891004951 substrate binding site [chemical binding]; other site 146891004952 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 146891004953 substrate binding site [chemical binding]; other site 146891004954 ligand binding site [chemical binding]; other site 146891004955 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 146891004956 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 146891004957 Cl- selectivity filter; other site 146891004958 Cl- binding residues [ion binding]; other site 146891004959 pore gating glutamate residue; other site 146891004960 dimer interface [polypeptide binding]; other site 146891004961 H+/Cl- coupling transport residue; other site 146891004962 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 146891004963 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 146891004964 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 146891004965 putative active site [active] 146891004966 putative substrate binding site [chemical binding]; other site 146891004967 putative cosubstrate binding site; other site 146891004968 catalytic site [active] 146891004969 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 146891004970 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 146891004971 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 146891004972 nucleotide binding site [chemical binding]; other site 146891004973 NEF interaction site [polypeptide binding]; other site 146891004974 SBD interface [polypeptide binding]; other site 146891004975 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 146891004976 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 146891004977 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 146891004978 shikimate binding site; other site 146891004979 NAD(P) binding site [chemical binding]; other site 146891004980 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 146891004981 argininosuccinate synthase; Provisional; Region: PRK13820 146891004982 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 146891004983 ANP binding site [chemical binding]; other site 146891004984 Substrate Binding Site II [chemical binding]; other site 146891004985 Substrate Binding Site I [chemical binding]; other site 146891004986 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 146891004987 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 146891004988 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 146891004989 putative catalytic motif [active] 146891004990 putative substrate binding site [chemical binding]; other site 146891004991 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 146891004992 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 146891004993 putative ADP-binding pocket [chemical binding]; other site 146891004994 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 146891004995 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 146891004996 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 146891004997 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 146891004998 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 146891004999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 146891005000 Walker A/P-loop; other site 146891005001 ATP binding site [chemical binding]; other site 146891005002 Q-loop/lid; other site 146891005003 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 146891005004 ABC transporter signature motif; other site 146891005005 Walker B; other site 146891005006 D-loop; other site 146891005007 H-loop/switch region; other site 146891005008 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 146891005009 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 146891005010 active site 146891005011 substrate binding site [chemical binding]; other site 146891005012 ATP binding site [chemical binding]; other site 146891005013 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 146891005014 threonine synthase; Reviewed; Region: PRK06721 146891005015 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 146891005016 homodimer interface [polypeptide binding]; other site 146891005017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891005018 catalytic residue [active]