-- dump date 20140620_000013 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167539000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167539000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167539000003 putative DNA binding surface [nucleotide binding]; other site 167539000004 dimer interface [polypeptide binding]; other site 167539000005 beta-clamp/clamp loader binding surface; other site 167539000006 beta-clamp/translesion DNA polymerase binding surface; other site 167539000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167539000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167539000009 dimerization interface [polypeptide binding]; other site 167539000010 ATP binding site [chemical binding]; other site 167539000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167539000012 dimerization interface [polypeptide binding]; other site 167539000013 ATP binding site [chemical binding]; other site 167539000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167539000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167539000016 active site 167539000017 tetramer interface [polypeptide binding]; other site 167539000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539000019 active site 167539000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 167539000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167539000022 CAP-like domain; other site 167539000023 active site 167539000024 primary dimer interface [polypeptide binding]; other site 167539000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539000026 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167539000027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000028 binding surface 167539000029 TPR motif; other site 167539000030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000031 binding surface 167539000032 TPR motif; other site 167539000033 TPR repeat; Region: TPR_11; pfam13414 167539000034 TPR repeat; Region: TPR_11; pfam13414 167539000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 167539000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167539000037 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 167539000038 Uncharacterized conserved protein [Function unknown]; Region: COG2928 167539000039 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 167539000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167539000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 167539000042 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 167539000043 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 167539000044 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 167539000045 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 167539000046 argininosuccinate lyase; Provisional; Region: PRK00855 167539000047 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167539000048 active sites [active] 167539000049 tetramer interface [polypeptide binding]; other site 167539000050 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167539000051 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167539000052 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167539000053 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 167539000054 FMN binding site [chemical binding]; other site 167539000055 active site 167539000056 catalytic residues [active] 167539000057 substrate binding site [chemical binding]; other site 167539000058 SelR domain; Region: SelR; cl15841 167539000059 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167539000060 dimer interface [polypeptide binding]; other site 167539000061 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167539000062 chaperone protein DnaJ; Provisional; Region: PRK14293 167539000063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539000064 HSP70 interaction site [polypeptide binding]; other site 167539000065 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167539000066 substrate binding site [polypeptide binding]; other site 167539000067 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167539000068 Zn binding sites [ion binding]; other site 167539000069 dimer interface [polypeptide binding]; other site 167539000070 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167539000071 CPxP motif; other site 167539000072 Predicted GTPases [General function prediction only]; Region: COG1162 167539000073 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539000074 RNA binding site [nucleotide binding]; other site 167539000075 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 167539000076 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167539000077 GTP/Mg2+ binding site [chemical binding]; other site 167539000078 G4 box; other site 167539000079 G5 box; other site 167539000080 G1 box; other site 167539000081 Switch I region; other site 167539000082 G2 box; other site 167539000083 G3 box; other site 167539000084 Switch II region; other site 167539000085 hypothetical protein; Validated; Region: PRK00153 167539000086 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167539000087 FAD binding domain; Region: FAD_binding_4; pfam01565 167539000088 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167539000089 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167539000090 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539000091 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539000092 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539000093 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167539000094 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167539000095 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167539000096 thiamine monophosphate kinase; Provisional; Region: PRK05731 167539000097 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167539000098 ATP binding site [chemical binding]; other site 167539000099 dimerization interface [polypeptide binding]; other site 167539000100 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 167539000101 active site 167539000102 elongation factor P; Validated; Region: PRK00529 167539000103 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167539000104 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167539000105 RNA binding site [nucleotide binding]; other site 167539000106 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167539000107 RNA binding site [nucleotide binding]; other site 167539000108 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167539000109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167539000110 carboxyltransferase (CT) interaction site; other site 167539000111 biotinylation site [posttranslational modification]; other site 167539000112 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 167539000113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000114 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539000115 NAD(P) binding site [chemical binding]; other site 167539000116 active site 167539000117 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167539000118 active site 167539000119 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 167539000120 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539000121 catalytic residue [active] 167539000122 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 167539000123 GMP synthase; Reviewed; Region: guaA; PRK00074 167539000124 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167539000125 AMP/PPi binding site [chemical binding]; other site 167539000126 candidate oxyanion hole; other site 167539000127 catalytic triad [active] 167539000128 potential glutamine specificity residues [chemical binding]; other site 167539000129 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167539000130 ATP Binding subdomain [chemical binding]; other site 167539000131 Ligand Binding sites [chemical binding]; other site 167539000132 Dimerization subdomain; other site 167539000133 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167539000134 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 167539000135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167539000136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 167539000137 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167539000138 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167539000139 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167539000140 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167539000141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167539000142 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167539000143 SWIM zinc finger; Region: SWIM; cl19527 167539000144 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 167539000145 SNF2 Helicase protein; Region: DUF3670; pfam12419 167539000146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539000147 ATP binding site [chemical binding]; other site 167539000148 putative Mg++ binding site [ion binding]; other site 167539000149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539000150 nucleotide binding region [chemical binding]; other site 167539000151 ATP-binding site [chemical binding]; other site 167539000152 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167539000153 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 167539000154 motif 1; other site 167539000155 active site 167539000156 motif 2; other site 167539000157 motif 3; other site 167539000158 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167539000159 arginine decarboxylase; Provisional; Region: PRK05354 167539000160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167539000161 dimer interface [polypeptide binding]; other site 167539000162 active site 167539000163 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539000164 catalytic residues [active] 167539000165 substrate binding site [chemical binding]; other site 167539000166 Nucleoside diphosphate kinase; Region: NDK; pfam00334 167539000167 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167539000168 active site 167539000169 multimer interface [polypeptide binding]; other site 167539000170 FAD dependent oxidoreductase; Region: DAO; pfam01266 167539000171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539000172 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167539000173 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167539000174 GatB domain; Region: GatB_Yqey; smart00845 167539000175 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 167539000176 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167539000177 CoA-binding site [chemical binding]; other site 167539000178 ATP-binding [chemical binding]; other site 167539000179 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167539000180 heterotetramer interface [polypeptide binding]; other site 167539000181 active site pocket [active] 167539000182 cleavage site 167539000183 HupE / UreJ protein; Region: HupE_UreJ; cl01011 167539000184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167539000185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539000186 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539000187 Walker A/P-loop; other site 167539000188 ATP binding site [chemical binding]; other site 167539000189 Q-loop/lid; other site 167539000190 ABC transporter signature motif; other site 167539000191 Walker B; other site 167539000192 D-loop; other site 167539000193 H-loop/switch region; other site 167539000194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539000195 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 167539000196 putative homodimer interface [polypeptide binding]; other site 167539000197 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 167539000198 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 167539000199 active site 167539000200 dimer interface [polypeptide binding]; other site 167539000201 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 167539000202 Ligand Binding Site [chemical binding]; other site 167539000203 Molecular Tunnel; other site 167539000204 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167539000205 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 167539000206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167539000207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539000208 S-adenosylmethionine binding site [chemical binding]; other site 167539000209 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 167539000210 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167539000211 Ligand binding site; other site 167539000212 Putative Catalytic site; other site 167539000213 DXD motif; other site 167539000214 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 167539000215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 167539000216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000217 binding surface 167539000218 TPR motif; other site 167539000219 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167539000220 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167539000221 NADP-binding site; other site 167539000222 homotetramer interface [polypeptide binding]; other site 167539000223 substrate binding site [chemical binding]; other site 167539000224 homodimer interface [polypeptide binding]; other site 167539000225 active site 167539000226 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 167539000227 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 167539000228 NADP binding site [chemical binding]; other site 167539000229 active site 167539000230 putative substrate binding site [chemical binding]; other site 167539000231 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167539000232 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 167539000233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539000234 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 167539000235 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 167539000236 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 167539000237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539000238 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167539000239 Walker A/P-loop; other site 167539000240 ATP binding site [chemical binding]; other site 167539000241 Q-loop/lid; other site 167539000242 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 167539000243 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 167539000244 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 167539000245 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167539000246 ABC transporter signature motif; other site 167539000247 Walker B; other site 167539000248 D-loop; other site 167539000249 H-loop/switch region; other site 167539000250 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 167539000251 PRC-barrel domain; Region: PRC; pfam05239 167539000252 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 167539000253 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167539000254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539000255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167539000256 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 167539000257 YGGT family; Region: YGGT; pfam02325 167539000258 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 167539000259 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167539000260 Cation transport protein; Region: TrkH; cl17365 167539000261 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167539000262 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 167539000263 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 167539000264 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 167539000265 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167539000266 nucleotide binding site/active site [active] 167539000267 HIT family signature motif; other site 167539000268 catalytic residue [active] 167539000269 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167539000270 active site 167539000271 catalytic residues [active] 167539000272 metal binding site [ion binding]; metal-binding site 167539000273 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 167539000274 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 167539000275 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167539000276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539000277 catalytic residue [active] 167539000278 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 167539000279 FeS assembly protein SufD; Region: sufD; TIGR01981 167539000280 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167539000281 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 167539000282 Walker A/P-loop; other site 167539000283 ATP binding site [chemical binding]; other site 167539000284 Q-loop/lid; other site 167539000285 ABC transporter signature motif; other site 167539000286 Walker B; other site 167539000287 D-loop; other site 167539000288 H-loop/switch region; other site 167539000289 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 167539000290 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 167539000291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167539000292 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 167539000293 phosphoglucomutase; Region: PLN02307 167539000294 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167539000295 active site 167539000296 substrate binding site [chemical binding]; other site 167539000297 metal binding site [ion binding]; metal-binding site 167539000298 recombination factor protein RarA; Reviewed; Region: PRK13342 167539000299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000300 Walker A motif; other site 167539000301 ATP binding site [chemical binding]; other site 167539000302 Walker B motif; other site 167539000303 arginine finger; other site 167539000304 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167539000305 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167539000306 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 167539000307 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167539000308 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167539000309 catalytic triad [active] 167539000310 Type III pantothenate kinase; Region: Pan_kinase; cl17198 167539000311 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 167539000312 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167539000313 Active Sites [active] 167539000314 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167539000315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539000316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539000317 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167539000318 transmembrane helices; other site 167539000319 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167539000320 TrkA-C domain; Region: TrkA_C; pfam02080 167539000321 TrkA-C domain; Region: TrkA_C; pfam02080 167539000322 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167539000323 Cation transport protein; Region: TrkH; cl17365 167539000324 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167539000325 Cation transport protein; Region: TrkH; cl17365 167539000326 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167539000327 TrkA-N domain; Region: TrkA_N; pfam02254 167539000328 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 167539000329 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167539000330 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167539000331 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167539000332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167539000333 ABC transporter; Region: ABC_tran_2; pfam12848 167539000334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167539000335 ABC transporter; Region: ABC_tran_2; pfam12848 167539000336 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167539000337 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167539000338 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167539000339 protein binding site [polypeptide binding]; other site 167539000340 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167539000341 light-harvesting-like protein 3; Provisional; Region: PLN00014 167539000342 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 167539000343 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 167539000344 generic binding surface II; other site 167539000345 generic binding surface I; other site 167539000346 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 167539000347 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 167539000348 RecR protein; Region: RecR; pfam02132 167539000349 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 167539000350 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167539000351 active site 167539000352 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 167539000353 Outer membrane efflux protein; Region: OEP; pfam02321 167539000354 Outer membrane efflux protein; Region: OEP; pfam02321 167539000355 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 167539000356 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167539000357 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167539000358 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167539000359 L-aspartate oxidase; Provisional; Region: PRK07395 167539000360 L-aspartate oxidase; Provisional; Region: PRK06175 167539000361 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167539000362 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 167539000363 substrate binding site [chemical binding]; other site 167539000364 putative active site [active] 167539000365 redox center [active] 167539000366 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539000367 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 167539000368 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167539000369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539000370 FeS/SAM binding site; other site 167539000371 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 167539000372 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167539000373 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 167539000374 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167539000375 active site 167539000376 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167539000377 active site 167539000378 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 167539000379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167539000380 ADP binding site [chemical binding]; other site 167539000381 magnesium binding site [ion binding]; other site 167539000382 putative shikimate binding site; other site 167539000383 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167539000384 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167539000385 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167539000386 C-terminal domain interface [polypeptide binding]; other site 167539000387 GSH binding site (G-site) [chemical binding]; other site 167539000388 dimer interface [polypeptide binding]; other site 167539000389 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167539000390 N-terminal domain interface [polypeptide binding]; other site 167539000391 dimer interface [polypeptide binding]; other site 167539000392 substrate binding pocket (H-site) [chemical binding]; other site 167539000393 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167539000394 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 167539000395 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 167539000396 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167539000397 active site 167539000398 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167539000399 putative hydrophobic ligand binding site [chemical binding]; other site 167539000400 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 167539000401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167539000402 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 167539000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167539000404 conserved hypothetical protein; Region: TIGR03492 167539000405 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167539000406 TIGR01777 family protein; Region: yfcH 167539000407 putative NAD(P) binding site [chemical binding]; other site 167539000408 putative active site [active] 167539000409 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167539000410 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539000411 HSP70 interaction site [polypeptide binding]; other site 167539000412 cysteine synthase; Region: PLN02565 167539000413 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167539000414 dimer interface [polypeptide binding]; other site 167539000415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000416 catalytic residue [active] 167539000417 hypothetical protein; Provisional; Region: PRK13683 167539000418 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539000419 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167539000420 Walker A/P-loop; other site 167539000421 ATP binding site [chemical binding]; other site 167539000422 Q-loop/lid; other site 167539000423 ABC transporter signature motif; other site 167539000424 Walker B; other site 167539000425 D-loop; other site 167539000426 H-loop/switch region; other site 167539000427 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 167539000428 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 167539000429 Short C-terminal domain; Region: SHOCT; pfam09851 167539000430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167539000431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000432 active site 167539000433 phosphorylation site [posttranslational modification] 167539000434 intermolecular recognition site; other site 167539000435 dimerization interface [polypeptide binding]; other site 167539000436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539000437 DNA binding site [nucleotide binding] 167539000438 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167539000439 DNA polymerase III subunit delta'; Validated; Region: PRK08485 167539000440 thymidylate kinase; Validated; Region: tmk; PRK00698 167539000441 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167539000442 TMP-binding site; other site 167539000443 ATP-binding site [chemical binding]; other site 167539000444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167539000445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167539000446 metal-binding site [ion binding] 167539000447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167539000448 Soluble P-type ATPase [General function prediction only]; Region: COG4087 167539000449 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167539000450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000451 binding surface 167539000452 TPR motif; other site 167539000453 DNA repair protein RadA; Provisional; Region: PRK11823 167539000454 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167539000455 Walker A motif; other site 167539000456 ATP binding site [chemical binding]; other site 167539000457 Walker B motif; other site 167539000458 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 167539000459 Ycf27; Reviewed; Region: orf27; CHL00148 167539000460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000461 active site 167539000462 phosphorylation site [posttranslational modification] 167539000463 intermolecular recognition site; other site 167539000464 dimerization interface [polypeptide binding]; other site 167539000465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539000466 DNA binding site [nucleotide binding] 167539000467 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 167539000468 putative phosphate acyltransferase; Provisional; Region: PRK05331 167539000469 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167539000470 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167539000471 dimer interface [polypeptide binding]; other site 167539000472 active site 167539000473 CoA binding pocket [chemical binding]; other site 167539000474 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 167539000475 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167539000476 putative acyl-acceptor binding pocket; other site 167539000477 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 167539000478 putative active site [active] 167539000479 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 167539000480 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167539000481 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167539000482 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167539000483 active site 167539000484 NTP binding site [chemical binding]; other site 167539000485 metal binding triad [ion binding]; metal-binding site 167539000486 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 167539000487 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 167539000488 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167539000489 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167539000490 active site lid residues [active] 167539000491 substrate binding pocket [chemical binding]; other site 167539000492 catalytic residues [active] 167539000493 substrate-Mg2+ binding site; other site 167539000494 aspartate-rich region 1; other site 167539000495 aspartate-rich region 2; other site 167539000496 phytoene desaturase; Region: phytoene_desat; TIGR02731 167539000497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167539000498 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167539000499 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167539000500 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167539000501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 167539000502 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167539000503 putative dimerization interface [polypeptide binding]; other site 167539000504 Predicted membrane protein [Function unknown]; Region: COG4094 167539000505 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167539000506 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167539000507 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167539000508 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167539000509 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167539000510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167539000511 ScpA/B protein; Region: ScpA_ScpB; cl00598 167539000512 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167539000513 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167539000514 active site 167539000515 Substrate binding site; other site 167539000516 Mg++ binding site; other site 167539000517 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167539000518 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167539000519 FAD binding site [chemical binding]; other site 167539000520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167539000521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539000522 DNA binding residues [nucleotide binding] 167539000523 dimerization interface [polypeptide binding]; other site 167539000524 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167539000525 putative active site [active] 167539000526 putative metal binding residues [ion binding]; other site 167539000527 signature motif; other site 167539000528 putative dimer interface [polypeptide binding]; other site 167539000529 putative phosphate binding site [ion binding]; other site 167539000530 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 167539000531 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 167539000532 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 167539000533 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167539000534 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 167539000535 NADH dehydrogenase; Region: NADHdh; cl00469 167539000536 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 167539000537 citrate synthase; Provisional; Region: PRK14036 167539000538 oxalacetate binding site [chemical binding]; other site 167539000539 citrylCoA binding site [chemical binding]; other site 167539000540 coenzyme A binding site [chemical binding]; other site 167539000541 catalytic triad [active] 167539000542 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 167539000543 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 167539000544 active site residue [active] 167539000545 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167539000546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000547 catalytic residue [active] 167539000548 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 167539000549 putative rRNA binding site [nucleotide binding]; other site 167539000550 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 167539000551 ligand-binding site [chemical binding]; other site 167539000552 AIR carboxylase; Region: AIRC; pfam00731 167539000553 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 167539000554 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 167539000555 active site 167539000556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539000557 S-adenosylmethionine binding site [chemical binding]; other site 167539000558 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 167539000559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167539000560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000561 active site 167539000562 phosphorylation site [posttranslational modification] 167539000563 intermolecular recognition site; other site 167539000564 dimerization interface [polypeptide binding]; other site 167539000565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539000566 DNA binding residues [nucleotide binding] 167539000567 dimerization interface [polypeptide binding]; other site 167539000568 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167539000569 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539000570 catalytic residue [active] 167539000571 MraW methylase family; Region: Methyltransf_5; cl17771 167539000572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539000573 S-adenosylmethionine binding site [chemical binding]; other site 167539000574 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 167539000575 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 167539000576 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167539000577 active site 167539000578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 167539000579 acyl-activating enzyme (AAE) consensus motif; other site 167539000580 active site 167539000581 CoA binding site [chemical binding]; other site 167539000582 AMP binding site [chemical binding]; other site 167539000583 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167539000584 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 167539000585 active site 167539000586 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 167539000587 putative active site [active] 167539000588 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 167539000589 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167539000590 glutathione synthetase; Provisional; Region: PRK05246 167539000591 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167539000592 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 167539000593 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167539000594 GSH binding site [chemical binding]; other site 167539000595 catalytic residues [active] 167539000596 peptide chain release factor 2; Validated; Region: prfB; PRK00578 167539000597 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167539000598 RF-1 domain; Region: RF-1; pfam00472 167539000599 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167539000600 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 167539000601 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 167539000602 trimer interface [polypeptide binding]; other site 167539000603 putative active site [active] 167539000604 Zn binding site [ion binding]; other site 167539000605 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167539000606 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167539000607 glutamine binding [chemical binding]; other site 167539000608 catalytic triad [active] 167539000609 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167539000610 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 167539000611 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167539000612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000614 homodimer interface [polypeptide binding]; other site 167539000615 catalytic residue [active] 167539000616 arginine-tRNA ligase; Region: PLN02286 167539000617 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 167539000618 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167539000619 active site 167539000620 HIGH motif; other site 167539000621 KMSK motif region; other site 167539000622 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 167539000623 tRNA binding surface [nucleotide binding]; other site 167539000624 anticodon binding site; other site 167539000625 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167539000626 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167539000627 dimerization interface [polypeptide binding]; other site 167539000628 active site 167539000629 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167539000630 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167539000631 trmE is a tRNA modification GTPase; Region: trmE; cd04164 167539000632 G1 box; other site 167539000633 GTP/Mg2+ binding site [chemical binding]; other site 167539000634 Switch I region; other site 167539000635 G2 box; other site 167539000636 Switch II region; other site 167539000637 G3 box; other site 167539000638 G4 box; other site 167539000639 G5 box; other site 167539000640 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167539000641 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 167539000642 hypothetical protein; Validated; Region: PRK00029 167539000643 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167539000644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167539000645 Zn2+ binding site [ion binding]; other site 167539000646 Mg2+ binding site [ion binding]; other site 167539000647 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167539000648 synthetase active site [active] 167539000649 NTP binding site [chemical binding]; other site 167539000650 metal binding site [ion binding]; metal-binding site 167539000651 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167539000652 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167539000653 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167539000654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167539000655 Walker A/P-loop; other site 167539000656 ATP binding site [chemical binding]; other site 167539000657 Q-loop/lid; other site 167539000658 ABC transporter signature motif; other site 167539000659 Walker B; other site 167539000660 D-loop; other site 167539000661 H-loop/switch region; other site 167539000662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167539000663 Walker A/P-loop; other site 167539000664 ATP binding site [chemical binding]; other site 167539000665 Q-loop/lid; other site 167539000666 ABC transporter signature motif; other site 167539000667 Walker B; other site 167539000668 D-loop; other site 167539000669 H-loop/switch region; other site 167539000670 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 167539000671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539000672 RNA binding surface [nucleotide binding]; other site 167539000673 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 167539000674 active site 167539000675 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167539000676 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 167539000677 GTP/Mg2+ binding site [chemical binding]; other site 167539000678 G4 box; other site 167539000679 G5 box; other site 167539000680 G1 box; other site 167539000681 Switch I region; other site 167539000682 G2 box; other site 167539000683 G3 box; other site 167539000684 Switch II region; other site 167539000685 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167539000686 substrate binding site [chemical binding]; other site 167539000687 hinge regions; other site 167539000688 ADP binding site [chemical binding]; other site 167539000689 catalytic site [active] 167539000690 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 167539000691 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167539000692 active site 167539000693 homodimer interface [polypeptide binding]; other site 167539000694 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167539000695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539000696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000697 homodimer interface [polypeptide binding]; other site 167539000698 catalytic residue [active] 167539000699 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 167539000700 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167539000701 quinone interaction residues [chemical binding]; other site 167539000702 active site 167539000703 catalytic residues [active] 167539000704 FMN binding site [chemical binding]; other site 167539000705 substrate binding site [chemical binding]; other site 167539000706 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167539000707 RNA/DNA hybrid binding site [nucleotide binding]; other site 167539000708 active site 167539000709 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167539000710 core dimer interface [polypeptide binding]; other site 167539000711 peripheral dimer interface [polypeptide binding]; other site 167539000712 L10 interface [polypeptide binding]; other site 167539000713 L11 interface [polypeptide binding]; other site 167539000714 putative EF-Tu interaction site [polypeptide binding]; other site 167539000715 putative EF-G interaction site [polypeptide binding]; other site 167539000716 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167539000717 23S rRNA interface [nucleotide binding]; other site 167539000718 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167539000719 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167539000720 mRNA/rRNA interface [nucleotide binding]; other site 167539000721 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167539000722 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167539000723 23S rRNA interface [nucleotide binding]; other site 167539000724 L7/L12 interface [polypeptide binding]; other site 167539000725 putative thiostrepton binding site; other site 167539000726 L25 interface [polypeptide binding]; other site 167539000727 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167539000728 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167539000729 putative homodimer interface [polypeptide binding]; other site 167539000730 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 167539000731 heterodimer interface [polypeptide binding]; other site 167539000732 homodimer interface [polypeptide binding]; other site 167539000733 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 167539000734 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167539000735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000736 Walker A motif; other site 167539000737 ATP binding site [chemical binding]; other site 167539000738 Walker B motif; other site 167539000739 arginine finger; other site 167539000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000741 Walker A motif; other site 167539000742 ATP binding site [chemical binding]; other site 167539000743 Walker B motif; other site 167539000744 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167539000745 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 167539000746 dimer interface [polypeptide binding]; other site 167539000747 active site 167539000748 metal binding site [ion binding]; metal-binding site 167539000749 glutathione binding site [chemical binding]; other site 167539000750 enolase; Provisional; Region: eno; PRK00077 167539000751 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167539000752 dimer interface [polypeptide binding]; other site 167539000753 metal binding site [ion binding]; metal-binding site 167539000754 substrate binding pocket [chemical binding]; other site 167539000755 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539000756 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 167539000757 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167539000758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539000759 Domain of unknown function (DUF897); Region: DUF897; cl01312 167539000760 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167539000761 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167539000762 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167539000763 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167539000764 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167539000765 dimer interface [polypeptide binding]; other site 167539000766 active site 167539000767 aspartate-rich active site metal binding site; other site 167539000768 allosteric magnesium binding site [ion binding]; other site 167539000769 Schiff base residues; other site 167539000770 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167539000771 active site 167539000772 metal binding site [ion binding]; metal-binding site 167539000773 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167539000774 MutS domain III; Region: MutS_III; pfam05192 167539000775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539000776 Walker A/P-loop; other site 167539000777 ATP binding site [chemical binding]; other site 167539000778 Q-loop/lid; other site 167539000779 ABC transporter signature motif; other site 167539000780 Walker B; other site 167539000781 D-loop; other site 167539000782 H-loop/switch region; other site 167539000783 Smr domain; Region: Smr; pfam01713 167539000784 GTPase CgtA; Reviewed; Region: obgE; PRK12299 167539000785 GTP1/OBG; Region: GTP1_OBG; pfam01018 167539000786 Obg GTPase; Region: Obg; cd01898 167539000787 G1 box; other site 167539000788 GTP/Mg2+ binding site [chemical binding]; other site 167539000789 Switch I region; other site 167539000790 G2 box; other site 167539000791 G3 box; other site 167539000792 Switch II region; other site 167539000793 G4 box; other site 167539000794 G5 box; other site 167539000795 CP12 domain; Region: CP12; cl14670 167539000796 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 167539000797 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167539000798 putative dimer interface [polypeptide binding]; other site 167539000799 N-terminal domain interface [polypeptide binding]; other site 167539000800 putative substrate binding pocket (H-site) [chemical binding]; other site 167539000801 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167539000802 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 167539000803 active site 167539000804 Zn binding site [ion binding]; other site 167539000805 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 167539000806 pheophytin binding site; other site 167539000807 chlorophyll binding site; other site 167539000808 quinone binding site; other site 167539000809 Fe binding site [ion binding]; other site 167539000810 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167539000811 Tetramer interface [polypeptide binding]; other site 167539000812 active site 167539000813 FMN-binding site [chemical binding]; other site 167539000814 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167539000815 active site 167539000816 intersubunit interface [polypeptide binding]; other site 167539000817 catalytic residue [active] 167539000818 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539000819 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167539000820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000821 Walker A motif; other site 167539000822 ATP binding site [chemical binding]; other site 167539000823 Walker B motif; other site 167539000824 arginine finger; other site 167539000825 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539000826 ATP sulphurylase; Region: sopT; TIGR00339 167539000827 ATP-sulfurylase; Region: ATPS; cd00517 167539000828 active site 167539000829 HXXH motif; other site 167539000830 flexible loop; other site 167539000831 Manganese-stabilizing protein / photosystem II polypeptide; Region: MSP; cl03326 167539000832 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167539000833 Flavoprotein; Region: Flavoprotein; cl19190 167539000834 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 167539000835 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 167539000836 Protein of unknown function (DUF565); Region: DUF565; pfam04483 167539000837 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167539000838 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167539000839 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167539000840 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 167539000841 active site 167539000842 DNA binding site [nucleotide binding] 167539000843 Creatinine amidohydrolase; Region: Creatininase; pfam02633 167539000844 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 167539000845 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 167539000846 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 167539000847 putative di-iron ligands [ion binding]; other site 167539000848 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167539000849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539000850 active site 167539000851 HIGH motif; other site 167539000852 nucleotide binding site [chemical binding]; other site 167539000853 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539000854 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167539000855 active site 167539000856 KMSKS motif; other site 167539000857 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167539000858 tRNA binding surface [nucleotide binding]; other site 167539000859 anticodon binding site; other site 167539000860 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167539000861 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167539000862 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 167539000863 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 167539000864 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 167539000865 active site 167539000866 substrate binding site [chemical binding]; other site 167539000867 metal binding site [ion binding]; metal-binding site 167539000868 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 167539000869 catalytic residues [active] 167539000870 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 167539000871 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167539000872 trimer interface [polypeptide binding]; other site 167539000873 active site 167539000874 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 167539000875 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167539000876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167539000877 ligand binding site [chemical binding]; other site 167539000878 flexible hinge region; other site 167539000879 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167539000880 putative switch regulator; other site 167539000881 non-specific DNA interactions [nucleotide binding]; other site 167539000882 DNA binding site [nucleotide binding] 167539000883 sequence specific DNA binding site [nucleotide binding]; other site 167539000884 putative cAMP binding site [chemical binding]; other site 167539000885 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167539000886 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 167539000887 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167539000888 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167539000889 putative active site [active] 167539000890 catalytic residue [active] 167539000891 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167539000892 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 167539000893 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 167539000894 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 167539000895 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167539000896 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167539000897 substrate binding site [chemical binding]; other site 167539000898 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167539000899 substrate binding site [chemical binding]; other site 167539000900 ligand binding site [chemical binding]; other site 167539000901 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167539000902 competence damage-inducible protein A; Provisional; Region: PRK00549 167539000903 putative MPT binding site; other site 167539000904 Competence-damaged protein; Region: CinA; pfam02464 167539000905 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167539000906 dimer interface [polypeptide binding]; other site 167539000907 active site 167539000908 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167539000909 folate binding site [chemical binding]; other site 167539000910 2TM domain; Region: 2TM; pfam13239 167539000911 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167539000912 integral membrane protein MviN; Region: mviN; TIGR01695 167539000913 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 167539000914 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 167539000915 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 167539000916 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 167539000917 Fe-S cluster binding site [ion binding]; other site 167539000918 substrate binding site [chemical binding]; other site 167539000919 catalytic site [active] 167539000920 DoxX; Region: DoxX; pfam07681 167539000921 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167539000922 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167539000923 purine monophosphate binding site [chemical binding]; other site 167539000924 dimer interface [polypeptide binding]; other site 167539000925 putative catalytic residues [active] 167539000926 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 167539000927 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 167539000928 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167539000929 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167539000930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167539000931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167539000932 dimer interface [polypeptide binding]; other site 167539000933 phosphorylation site [posttranslational modification] 167539000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539000935 ATP binding site [chemical binding]; other site 167539000936 Mg2+ binding site [ion binding]; other site 167539000937 G-X-G motif; other site 167539000938 cobalamin synthase; Reviewed; Region: cobS; PRK00235 167539000939 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 167539000940 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 167539000941 Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533 167539000942 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167539000943 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167539000944 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167539000945 Domain of unknown function DUF21; Region: DUF21; pfam01595 167539000946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167539000947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167539000948 Transporter associated domain; Region: CorC_HlyC; smart01091 167539000949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539000950 active site 167539000951 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 167539000952 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167539000953 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167539000954 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167539000955 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl18976 167539000956 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 167539000957 RNase_H superfamily; Region: RNase_H_2; pfam13482 167539000958 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167539000959 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167539000960 active site 167539000961 substrate binding site [chemical binding]; other site 167539000962 metal binding site [ion binding]; metal-binding site 167539000963 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167539000964 active site 167539000965 dimerization interface [polypeptide binding]; other site 167539000966 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 167539000967 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 167539000968 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167539000969 putative active site pocket [active] 167539000970 4-fold oligomerization interface [polypeptide binding]; other site 167539000971 metal binding residues [ion binding]; metal-binding site 167539000972 3-fold/trimer interface [polypeptide binding]; other site 167539000973 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 167539000974 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167539000975 NAD binding site [chemical binding]; other site 167539000976 homotetramer interface [polypeptide binding]; other site 167539000977 homodimer interface [polypeptide binding]; other site 167539000978 substrate binding site [chemical binding]; other site 167539000979 active site 167539000980 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167539000981 putative catalytic residue [active] 167539000982 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167539000983 inhibitor-cofactor binding pocket; inhibition site 167539000984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000985 catalytic residue [active] 167539000986 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167539000987 dimer interface [polypeptide binding]; other site 167539000988 ADP-ribose binding site [chemical binding]; other site 167539000989 active site 167539000990 nudix motif; other site 167539000991 metal binding site [ion binding]; metal-binding site 167539000992 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167539000993 catalytic center binding site [active] 167539000994 ATP binding site [chemical binding]; other site 167539000995 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 167539000996 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 167539000997 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167539000998 metal ion-dependent adhesion site (MIDAS); other site 167539000999 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 167539001000 mce related protein; Region: MCE; pfam02470 167539001001 RNA polymerase Rpb4; Region: RNA_pol_Rpb4; cl00638 167539001002 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 167539001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539001004 Walker A/P-loop; other site 167539001005 ATP binding site [chemical binding]; other site 167539001006 Q-loop/lid; other site 167539001007 ABC transporter signature motif; other site 167539001008 Walker B; other site 167539001009 D-loop; other site 167539001010 H-loop/switch region; other site 167539001011 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167539001012 phosphate binding site [ion binding]; other site 167539001013 putative substrate binding pocket [chemical binding]; other site 167539001014 dimer interface [polypeptide binding]; other site 167539001015 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 167539001016 NADH dehydrogenase subunit B; Validated; Region: PRK06411 167539001017 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 167539001018 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 167539001019 Rubredoxin [Energy production and conversion]; Region: COG1773 167539001020 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167539001021 iron binding site [ion binding]; other site 167539001022 Ycf48-like protein; Provisional; Region: PRK13684 167539001023 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 167539001024 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167539001025 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 167539001026 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167539001027 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167539001028 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 167539001029 photosystem II reaction center protein J; Provisional; Region: PRK02565 167539001030 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167539001031 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 167539001032 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167539001033 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 167539001034 dimerization interface [polypeptide binding]; other site 167539001035 putative ATP binding site [chemical binding]; other site 167539001036 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167539001037 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167539001038 active site 167539001039 NTP binding site [chemical binding]; other site 167539001040 metal binding triad [ion binding]; metal-binding site 167539001041 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167539001042 Part of AAA domain; Region: AAA_19; pfam13245 167539001043 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 167539001044 Phycobilisome protein; Region: Phycobilisome; cl08227 167539001045 Phycobilisome protein; Region: Phycobilisome; cl08227 167539001046 HEAT repeats; Region: HEAT_2; pfam13646 167539001047 HEAT repeats; Region: HEAT_2; pfam13646 167539001048 HEAT repeats; Region: HEAT_2; pfam13646 167539001049 HEAT repeats; Region: HEAT_2; pfam13646 167539001050 HEAT repeats; Region: HEAT_2; pfam13646 167539001051 HEAT repeats; Region: HEAT_2; pfam13646 167539001052 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 167539001053 CpeS-like protein; Region: CpeS; pfam09367 167539001054 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 167539001055 PUCC protein; Region: PUCC; pfam03209 167539001056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167539001057 nucleotide binding site [chemical binding]; other site 167539001058 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167539001059 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167539001060 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167539001061 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167539001062 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167539001063 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 167539001064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539001065 motif II; other site 167539001066 30S ribosomal protein S1; Reviewed; Region: PRK07400 167539001067 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167539001068 RNA binding site [nucleotide binding]; other site 167539001069 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167539001070 RNA binding site [nucleotide binding]; other site 167539001071 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539001072 RNA binding site [nucleotide binding]; other site 167539001073 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167539001074 ATP cone domain; Region: ATP-cone; pfam03477 167539001075 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 167539001076 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 167539001077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539001078 catalytic loop [active] 167539001079 iron binding site [ion binding]; other site 167539001080 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 167539001081 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167539001082 active site 167539001083 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 167539001084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539001085 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 167539001086 cell division topological specificity factor MinE; Provisional; Region: PRK13988 167539001087 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167539001088 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167539001089 P-loop; other site 167539001090 ADP binding residues [chemical binding]; other site 167539001091 Switch I; other site 167539001092 Switch II; other site 167539001093 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167539001094 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167539001095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167539001096 Zn2+ binding site [ion binding]; other site 167539001097 Mg2+ binding site [ion binding]; other site 167539001098 carboxyl-terminal processing protease; Provisional; Region: PLN00049 167539001099 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167539001100 protein binding site [polypeptide binding]; other site 167539001101 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167539001102 Catalytic dyad [active] 167539001103 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167539001104 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167539001105 Qi binding site; other site 167539001106 intrachain domain interface; other site 167539001107 interchain domain interface [polypeptide binding]; other site 167539001108 heme bH binding site [chemical binding]; other site 167539001109 heme bL binding site [chemical binding]; other site 167539001110 Qo binding site; other site 167539001111 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167539001112 interchain domain interface [polypeptide binding]; other site 167539001113 intrachain domain interface; other site 167539001114 Qi binding site; other site 167539001115 Qo binding site; other site 167539001116 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 167539001117 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167539001118 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167539001119 DNA binding site [nucleotide binding] 167539001120 catalytic residue [active] 167539001121 H2TH interface [polypeptide binding]; other site 167539001122 putative catalytic residues [active] 167539001123 turnover-facilitating residue; other site 167539001124 intercalation triad [nucleotide binding]; other site 167539001125 8OG recognition residue [nucleotide binding]; other site 167539001126 putative reading head residues; other site 167539001127 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167539001128 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167539001129 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 167539001130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167539001131 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 167539001132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167539001133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167539001134 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167539001135 NAD(P) binding site [chemical binding]; other site 167539001136 catalytic residues [active] 167539001137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001138 flavoprotein, HI0933 family; Region: TIGR00275 167539001139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001140 Uncharacterized conserved protein [Function unknown]; Region: COG0398 167539001141 Rubredoxin [Energy production and conversion]; Region: COG1773 167539001142 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167539001143 iron binding site [ion binding]; other site 167539001144 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167539001145 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167539001146 Ligand binding site; other site 167539001147 Putative Catalytic site; other site 167539001148 DXD motif; other site 167539001149 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 167539001150 GtrA-like protein; Region: GtrA; pfam04138 167539001151 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167539001152 trimer interface [polypeptide binding]; other site 167539001153 active site 167539001154 dimer interface [polypeptide binding]; other site 167539001155 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167539001156 active site 167539001157 dinuclear metal binding site [ion binding]; other site 167539001158 dimerization interface [polypeptide binding]; other site 167539001159 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 167539001160 active site 167539001161 SAM binding site [chemical binding]; other site 167539001162 homodimer interface [polypeptide binding]; other site 167539001163 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 167539001164 GTP-binding protein Der; Reviewed; Region: PRK00093 167539001165 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 167539001166 G1 box; other site 167539001167 GTP/Mg2+ binding site [chemical binding]; other site 167539001168 Switch I region; other site 167539001169 G2 box; other site 167539001170 Switch II region; other site 167539001171 G3 box; other site 167539001172 G4 box; other site 167539001173 G5 box; other site 167539001174 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 167539001175 G1 box; other site 167539001176 GTP/Mg2+ binding site [chemical binding]; other site 167539001177 Switch I region; other site 167539001178 G2 box; other site 167539001179 G3 box; other site 167539001180 Switch II region; other site 167539001181 G4 box; other site 167539001182 G5 box; other site 167539001183 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 167539001184 Cobalt transport protein; Region: CbiQ; cl00463 167539001185 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167539001186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 167539001187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539001188 catalytic residue [active] 167539001189 Protein of unknown function (DUF552); Region: DUF552; cl00775 167539001190 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 167539001191 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 167539001192 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 167539001193 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167539001194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539001195 Recombination protein O N terminal; Region: RecO_N; pfam11967 167539001196 DNA repair protein RecO; Region: reco; TIGR00613 167539001197 Recombination protein O C terminal; Region: RecO_C; pfam02565 167539001198 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 167539001199 intersubunit interface [polypeptide binding]; other site 167539001200 active site 167539001201 catalytic residue [active] 167539001202 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 167539001203 30S subunit binding site; other site 167539001204 lipoate-protein ligase B; Provisional; Region: PRK14344 167539001205 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167539001206 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 167539001207 acyl-activating enzyme (AAE) consensus motif; other site 167539001208 putative AMP binding site [chemical binding]; other site 167539001209 putative active site [active] 167539001210 putative CoA binding site [chemical binding]; other site 167539001211 YlqD protein; Region: YlqD; pfam11068 167539001212 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167539001213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167539001214 E3 interaction surface; other site 167539001215 lipoyl attachment site [posttranslational modification]; other site 167539001216 e3 binding domain; Region: E3_binding; pfam02817 167539001217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 167539001218 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 167539001219 cysteine synthase; Region: PLN02565 167539001220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167539001221 dimer interface [polypeptide binding]; other site 167539001222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001223 catalytic residue [active] 167539001224 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 167539001225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539001226 catalytic residue [active] 167539001227 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167539001228 homodimer interface [polypeptide binding]; other site 167539001229 substrate-cofactor binding pocket; other site 167539001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001231 catalytic residue [active] 167539001232 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 167539001233 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167539001234 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167539001235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539001236 RNA binding surface [nucleotide binding]; other site 167539001237 Haemolytic domain; Region: Haemolytic; pfam01809 167539001238 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 167539001239 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167539001240 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539001241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539001242 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539001243 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167539001244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539001245 catalytic residue [active] 167539001246 NifU-like domain; Region: NifU; pfam01106 167539001247 malate:quinone oxidoreductase; Validated; Region: PRK05257 167539001248 Predicted dehydrogenase [General function prediction only]; Region: COG0579 167539001249 GTP-binding protein LepA; Provisional; Region: PRK05433 167539001250 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 167539001251 G1 box; other site 167539001252 putative GEF interaction site [polypeptide binding]; other site 167539001253 GTP/Mg2+ binding site [chemical binding]; other site 167539001254 Switch I region; other site 167539001255 G2 box; other site 167539001256 G3 box; other site 167539001257 Switch II region; other site 167539001258 G4 box; other site 167539001259 G5 box; other site 167539001260 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167539001261 Elongation Factor G, domain II; Region: EFG_II; pfam14492 167539001262 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167539001263 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167539001264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 167539001265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001266 dimer interface [polypeptide binding]; other site 167539001267 conserved gate region; other site 167539001268 ABC-ATPase subunit interface; other site 167539001269 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167539001270 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167539001271 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167539001272 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167539001273 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 167539001274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001275 S-adenosylmethionine binding site [chemical binding]; other site 167539001276 Transglycosylase; Region: Transgly; pfam00912 167539001277 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 167539001278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 167539001279 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958 167539001280 putative active site [active] 167539001281 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539001282 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167539001283 substrate binding site [chemical binding]; other site 167539001284 glutamase interaction surface [polypeptide binding]; other site 167539001285 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167539001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001287 S-adenosylmethionine binding site [chemical binding]; other site 167539001288 Protein of unknown function (DUF721); Region: DUF721; pfam05258 167539001289 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 167539001290 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 167539001291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167539001292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167539001293 Walker A/P-loop; other site 167539001294 ATP binding site [chemical binding]; other site 167539001295 Q-loop/lid; other site 167539001296 ABC transporter signature motif; other site 167539001297 Walker B; other site 167539001298 D-loop; other site 167539001299 H-loop/switch region; other site 167539001300 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 167539001301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167539001302 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167539001303 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 167539001304 active site 167539001305 metal binding site [ion binding]; metal-binding site 167539001306 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167539001307 domain I; other site 167539001308 DNA binding groove [nucleotide binding] 167539001309 phosphate binding site [ion binding]; other site 167539001310 domain II; other site 167539001311 domain III; other site 167539001312 nucleotide binding site [chemical binding]; other site 167539001313 catalytic site [active] 167539001314 domain IV; other site 167539001315 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167539001316 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167539001317 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 167539001318 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167539001319 putative dimer interface [polypeptide binding]; other site 167539001320 active site pocket [active] 167539001321 putative cataytic base [active] 167539001322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 167539001323 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167539001324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539001325 active site 167539001326 catalytic tetrad [active] 167539001327 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 167539001328 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167539001329 Lumazine binding domain; Region: Lum_binding; pfam00677 167539001330 Lumazine binding domain; Region: Lum_binding; pfam00677 167539001331 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001332 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167539001333 Subunit I/III interface [polypeptide binding]; other site 167539001334 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 167539001335 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 167539001336 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00139 167539001337 Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_5; cd13919 167539001338 CuA binuclear center [ion binding]; other site 167539001339 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 167539001340 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 167539001341 putative active site [active] 167539001342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539001343 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 167539001344 Walker A/P-loop; other site 167539001345 ATP binding site [chemical binding]; other site 167539001346 Q-loop/lid; other site 167539001347 ABC transporter signature motif; other site 167539001348 Walker B; other site 167539001349 D-loop; other site 167539001350 H-loop/switch region; other site 167539001351 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 167539001352 ABC-2 type transporter; Region: ABC2_membrane; cl17235 167539001353 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 167539001354 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 167539001355 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167539001356 ring oligomerisation interface [polypeptide binding]; other site 167539001357 ATP/Mg binding site [chemical binding]; other site 167539001358 stacking interactions; other site 167539001359 hinge regions; other site 167539001360 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167539001361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167539001362 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167539001363 NAD(P) binding site [chemical binding]; other site 167539001364 homotetramer interface [polypeptide binding]; other site 167539001365 homodimer interface [polypeptide binding]; other site 167539001366 active site 167539001367 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167539001368 substrate binding site; other site 167539001369 dimer interface; other site 167539001370 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167539001371 dimer interface [polypeptide binding]; other site 167539001372 catalytic triad [active] 167539001373 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 167539001374 putative active site [active] 167539001375 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 167539001376 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 167539001377 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 167539001378 active site 167539001379 SAM binding site [chemical binding]; other site 167539001380 homodimer interface [polypeptide binding]; other site 167539001381 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 167539001382 apocytochrome f; Reviewed; Region: PRK02693 167539001383 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167539001384 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167539001385 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 167539001386 cytochrome b subunit interaction site [polypeptide binding]; other site 167539001387 [2Fe-2S] cluster binding site [ion binding]; other site 167539001388 Uncharacterized protein conserved in cyanobacteria 167539001389 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 167539001390 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 167539001391 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167539001392 Guanylate kinase; Region: Guanylate_kin; pfam00625 167539001393 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167539001394 catalytic site [active] 167539001395 G-X2-G-X-G-K; other site 167539001396 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 167539001397 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167539001398 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 167539001399 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 167539001400 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167539001401 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 167539001402 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167539001403 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167539001404 active site 167539001405 HIGH motif; other site 167539001406 KMSKS motif; other site 167539001407 Src Homology 3 domain superfamily; Region: SH3; cd00174 167539001408 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 167539001409 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167539001410 active site 167539001411 short chain dehydrogenase; Provisional; Region: PRK12367 167539001412 NAD(P) binding site [chemical binding]; other site 167539001413 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167539001414 DRTGG domain; Region: DRTGG; pfam07085 167539001415 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 167539001416 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 167539001417 prohibitin homologues; Region: PHB; smart00244 167539001418 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 167539001419 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167539001420 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539001421 inhibitor-cofactor binding pocket; inhibition site 167539001422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001423 catalytic residue [active] 167539001424 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167539001425 putative catalytic site [active] 167539001426 putative phosphate binding site [ion binding]; other site 167539001427 active site 167539001428 metal binding site A [ion binding]; metal-binding site 167539001429 DNA binding site [nucleotide binding] 167539001430 putative AP binding site [nucleotide binding]; other site 167539001431 putative metal binding site B [ion binding]; other site 167539001432 hypothetical protein; Provisional; Region: PRK04194 167539001433 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 167539001434 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 167539001435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001436 dimer interface [polypeptide binding]; other site 167539001437 conserved gate region; other site 167539001438 putative PBP binding loops; other site 167539001439 ABC-ATPase subunit interface; other site 167539001440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001441 dimer interface [polypeptide binding]; other site 167539001442 conserved gate region; other site 167539001443 putative PBP binding loops; other site 167539001444 ABC-ATPase subunit interface; other site 167539001445 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167539001446 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167539001447 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167539001448 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 167539001449 aromatic arch; other site 167539001450 DCoH dimer interaction site [polypeptide binding]; other site 167539001451 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167539001452 DCoH tetramer interaction site [polypeptide binding]; other site 167539001453 substrate binding site [chemical binding]; other site 167539001454 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 167539001455 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167539001456 active site 167539001457 Zn binding site [ion binding]; other site 167539001458 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167539001459 dimer interface [polypeptide binding]; other site 167539001460 substrate binding site [chemical binding]; other site 167539001461 metal binding sites [ion binding]; metal-binding site 167539001462 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167539001463 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167539001464 domain interfaces; other site 167539001465 active site 167539001466 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 167539001467 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539001468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539001469 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539001470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539001471 DNA binding residues [nucleotide binding] 167539001472 primosome assembly protein PriA; Validated; Region: PRK05580 167539001473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539001474 ATP binding site [chemical binding]; other site 167539001475 putative Mg++ binding site [ion binding]; other site 167539001476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539001477 ATP-binding site [chemical binding]; other site 167539001478 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167539001479 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167539001480 feedback inhibition sensing region; other site 167539001481 homohexameric interface [polypeptide binding]; other site 167539001482 nucleotide binding site [chemical binding]; other site 167539001483 N-acetyl-L-glutamate binding site [chemical binding]; other site 167539001484 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167539001485 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167539001486 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167539001487 ssDNA binding site [nucleotide binding]; other site 167539001488 dimer interface [polypeptide binding]; other site 167539001489 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539001490 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 167539001491 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 167539001492 adenosine kinase; Provisional; Region: PTZ00247 167539001493 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 167539001494 substrate binding site [chemical binding]; other site 167539001495 ATP binding site [chemical binding]; other site 167539001496 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167539001497 GDP-binding site [chemical binding]; other site 167539001498 ACT binding site; other site 167539001499 IMP binding site; other site 167539001500 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 167539001501 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167539001502 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 167539001503 dimer interface [polypeptide binding]; other site 167539001504 motif 1; other site 167539001505 active site 167539001506 motif 2; other site 167539001507 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167539001508 putative deacylase active site [active] 167539001509 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167539001510 anticodon binding site; other site 167539001511 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167539001512 dimer interface [polypeptide binding]; other site 167539001513 substrate binding site [chemical binding]; other site 167539001514 metal binding sites [ion binding]; metal-binding site 167539001515 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167539001516 putative ArsC-like catalytic residues; other site 167539001517 putative TRX-like catalytic residues [active] 167539001518 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167539001519 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539001520 Catalytic site [active] 167539001521 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 167539001522 dihydroorotase; Provisional; Region: PRK07369 167539001523 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 167539001524 active site 167539001525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167539001526 catalytic core [active] 167539001527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167539001528 catalytic core [active] 167539001529 CAAX protease self-immunity; Region: Abi; pfam02517 167539001530 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167539001531 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 167539001532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167539001533 transaldolase-like protein; Provisional; Region: PTZ00411 167539001534 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167539001535 active site 167539001536 dimer interface [polypeptide binding]; other site 167539001537 catalytic residue [active] 167539001538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001539 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 167539001540 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 167539001541 hinge region; other site 167539001542 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167539001543 putative nucleotide binding site [chemical binding]; other site 167539001544 uridine monophosphate binding site [chemical binding]; other site 167539001545 homohexameric interface [polypeptide binding]; other site 167539001546 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 167539001547 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167539001548 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167539001549 homodimer interface [polypeptide binding]; other site 167539001550 Walker A motif; other site 167539001551 ATP binding site [chemical binding]; other site 167539001552 hydroxycobalamin binding site [chemical binding]; other site 167539001553 Walker B motif; other site 167539001554 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167539001555 active site 167539001556 catalytic residues [active] 167539001557 DNA binding site [nucleotide binding] 167539001558 Int/Topo IB signature motif; other site 167539001559 ferrochelatase; Reviewed; Region: hemH; PRK00035 167539001560 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167539001561 C-terminal domain interface [polypeptide binding]; other site 167539001562 active site 167539001563 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167539001564 active site 167539001565 N-terminal domain interface [polypeptide binding]; other site 167539001566 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167539001567 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167539001568 PYR/PP interface [polypeptide binding]; other site 167539001569 dimer interface [polypeptide binding]; other site 167539001570 TPP binding site [chemical binding]; other site 167539001571 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 167539001572 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167539001573 TPP-binding site [chemical binding]; other site 167539001574 dimer interface [polypeptide binding]; other site 167539001575 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 167539001576 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167539001577 30S ribosomal protein S1; Reviewed; Region: PRK07400 167539001578 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539001579 RNA binding site [nucleotide binding]; other site 167539001580 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167539001581 RNA binding site [nucleotide binding]; other site 167539001582 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539001583 RNA binding site [nucleotide binding]; other site 167539001584 Creatinine amidohydrolase; Region: Creatininase; pfam02633 167539001585 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167539001586 dinuclear metal binding motif [ion binding]; other site 167539001587 acyl-ACP reductase; Provisional; Region: PRK14982 167539001588 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 167539001589 NAD(P) binding pocket [chemical binding]; other site 167539001590 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 167539001591 short chain dehydrogenase; Provisional; Region: PRK07454 167539001592 classical (c) SDRs; Region: SDR_c; cd05233 167539001593 NAD(P) binding site [chemical binding]; other site 167539001594 active site 167539001595 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 167539001596 active site 167539001597 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 167539001598 active site 167539001599 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 167539001600 Peptidase family M50; Region: Peptidase_M50; pfam02163 167539001601 active site 167539001602 putative substrate binding region [chemical binding]; other site 167539001603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167539001604 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 167539001605 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 167539001606 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 167539001607 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 167539001608 NAD(P) binding site [chemical binding]; other site 167539001609 active site 167539001610 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167539001611 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167539001612 P-loop; other site 167539001613 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167539001614 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167539001615 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167539001616 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 167539001617 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 167539001618 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167539001619 putative hexamer interface [polypeptide binding]; other site 167539001620 putative hexagonal pore; other site 167539001621 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167539001622 putative hexamer interface [polypeptide binding]; other site 167539001623 putative hexagonal pore; other site 167539001624 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167539001625 active site 167539001626 dimerization interface [polypeptide binding]; other site 167539001627 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167539001628 Hexamer interface [polypeptide binding]; other site 167539001629 Hexagonal pore residue; other site 167539001630 Hexagonal pore; other site 167539001631 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167539001632 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167539001633 dimer interface [polypeptide binding]; other site 167539001634 catalytic residue [active] 167539001635 metal binding site [ion binding]; metal-binding site 167539001636 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167539001637 multimerization interface [polypeptide binding]; other site 167539001638 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167539001639 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 167539001640 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167539001641 Hexamer/Pentamer interface [polypeptide binding]; other site 167539001642 central pore; other site 167539001643 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167539001644 Hexamer/Pentamer interface [polypeptide binding]; other site 167539001645 central pore; other site 167539001646 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167539001647 Hexamer interface [polypeptide binding]; other site 167539001648 Hexagonal pore residue; other site 167539001649 Hexagonal pore; other site 167539001650 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167539001651 aromatic arch; other site 167539001652 DCoH dimer interaction site [polypeptide binding]; other site 167539001653 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167539001654 DCoH tetramer interaction site [polypeptide binding]; other site 167539001655 substrate binding site [chemical binding]; other site 167539001656 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167539001657 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167539001658 homotrimer interaction site [polypeptide binding]; other site 167539001659 putative active site [active] 167539001660 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 167539001661 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 167539001662 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 167539001663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539001664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167539001665 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 167539001666 Walker A/P-loop; other site 167539001667 ATP binding site [chemical binding]; other site 167539001668 Q-loop/lid; other site 167539001669 ABC transporter signature motif; other site 167539001670 Walker B; other site 167539001671 D-loop; other site 167539001672 H-loop/switch region; other site 167539001673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 167539001674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539001675 Coenzyme A binding pocket [chemical binding]; other site 167539001676 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167539001677 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 167539001678 Probable Catalytic site; other site 167539001679 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 167539001680 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 167539001681 DnaA N-terminal domain; Region: DnaA_N; pfam11638 167539001682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539001683 Walker A motif; other site 167539001684 ATP binding site [chemical binding]; other site 167539001685 Walker B motif; other site 167539001686 arginine finger; other site 167539001687 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167539001688 DnaA box-binding interface [nucleotide binding]; other site 167539001689 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167539001690 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167539001691 C-terminal domain interface [polypeptide binding]; other site 167539001692 GSH binding site (G-site) [chemical binding]; other site 167539001693 dimer interface [polypeptide binding]; other site 167539001694 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167539001695 N-terminal domain interface [polypeptide binding]; other site 167539001696 glutathione reductase; Validated; Region: PRK06116 167539001697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539001699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001700 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 167539001701 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 167539001702 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167539001703 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167539001704 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167539001705 active site 167539001706 substrate binding pocket [chemical binding]; other site 167539001707 dimer interface [polypeptide binding]; other site 167539001708 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167539001709 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167539001710 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167539001711 substrate binding site [chemical binding]; other site 167539001712 active site 167539001713 catalytic residues [active] 167539001714 heterodimer interface [polypeptide binding]; other site 167539001715 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001716 YciI-like protein; Reviewed; Region: PRK12864 167539001717 Cytochrome c; Region: Cytochrom_C; cl11414 167539001718 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 167539001719 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539001720 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539001721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539001722 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539001723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539001724 DNA binding residues [nucleotide binding] 167539001725 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 167539001726 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 167539001727 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167539001728 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 167539001729 metal binding site [ion binding]; metal-binding site 167539001730 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167539001731 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167539001732 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539001733 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167539001734 Glucose inhibited division protein A; Region: GIDA; pfam01134 167539001735 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 167539001736 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001737 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 167539001738 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 167539001739 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167539001740 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 167539001741 Walker A/P-loop; other site 167539001742 ATP binding site [chemical binding]; other site 167539001743 Q-loop/lid; other site 167539001744 ABC transporter signature motif; other site 167539001745 Walker B; other site 167539001746 D-loop; other site 167539001747 H-loop/switch region; other site 167539001748 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 167539001749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001750 dimer interface [polypeptide binding]; other site 167539001751 conserved gate region; other site 167539001752 putative PBP binding loops; other site 167539001753 ABC-ATPase subunit interface; other site 167539001754 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 167539001755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001756 dimer interface [polypeptide binding]; other site 167539001757 conserved gate region; other site 167539001758 putative PBP binding loops; other site 167539001759 ABC-ATPase subunit interface; other site 167539001760 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 167539001761 Predicted protein 167539001762 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 167539001763 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167539001764 RNase_H superfamily; Region: RNase_H_2; pfam13482 167539001765 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 167539001766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539001767 ATP binding site [chemical binding]; other site 167539001768 putative Mg++ binding site [ion binding]; other site 167539001769 AAA domain; Region: AAA_12; pfam13087 167539001770 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 167539001771 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 167539001772 putative active site [active] 167539001773 putative NTP binding site [chemical binding]; other site 167539001774 putative nucleic acid binding site [nucleotide binding]; other site 167539001775 SWIM zinc finger; Region: SWIM; pfam04434 167539001776 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001777 Leucine rich repeat variant; Region: LRV; pfam01816 167539001778 HEAT repeats; Region: HEAT_2; pfam13646 167539001779 Leucine rich repeat variant; Region: LRV; pfam01816 167539001780 HEAT repeats; Region: HEAT_2; pfam13646 167539001781 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 167539001782 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 167539001783 DEAD-like helicases superfamily; Region: DEXDc; smart00487 167539001784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539001785 ATP binding site [chemical binding]; other site 167539001786 putative Mg++ binding site [ion binding]; other site 167539001787 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 167539001788 Methyltransferase domain; Region: Methyltransf_26; pfam13659 167539001789 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 167539001790 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 167539001791 putative amphipathic alpha helix; other site 167539001792 Predicted membrane protein [Function unknown]; Region: COG4709 167539001793 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 167539001794 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167539001795 Cupin domain; Region: Cupin_2; pfam07883 167539001796 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 167539001797 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001798 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167539001799 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 167539001800 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 167539001801 NADP binding site [chemical binding]; other site 167539001802 active site 167539001803 regulatory binding site [polypeptide binding]; other site 167539001804 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 167539001805 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167539001806 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 167539001807 Walker A/P-loop; other site 167539001808 ATP binding site [chemical binding]; other site 167539001809 Q-loop/lid; other site 167539001810 ABC transporter signature motif; other site 167539001811 Walker B; other site 167539001812 D-loop; other site 167539001813 H-loop/switch region; other site 167539001814 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 167539001815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001816 dimer interface [polypeptide binding]; other site 167539001817 conserved gate region; other site 167539001818 putative PBP binding loops; other site 167539001819 ABC-ATPase subunit interface; other site 167539001820 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 167539001821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001822 dimer interface [polypeptide binding]; other site 167539001823 conserved gate region; other site 167539001824 putative PBP binding loops; other site 167539001825 ABC-ATPase subunit interface; other site 167539001826 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 167539001827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 167539001828 substrate binding pocket [chemical binding]; other site 167539001829 membrane-bound complex binding site; other site 167539001830 hinge residues; other site 167539001831 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167539001832 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 167539001833 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167539001834 NAD(P) binding site [chemical binding]; other site 167539001835 homodimer interface [polypeptide binding]; other site 167539001836 substrate binding site [chemical binding]; other site 167539001837 active site 167539001838 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167539001839 Mg++ binding site [ion binding]; other site 167539001840 putative catalytic motif [active] 167539001841 putative substrate binding site [chemical binding]; other site 167539001842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001843 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539001844 NAD(P) binding site [chemical binding]; other site 167539001845 active site 167539001846 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 167539001847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539001848 putative ADP-binding pocket [chemical binding]; other site 167539001849 valyl-tRNA synthetase; Provisional; Region: valS; PRK14900 167539001850 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167539001851 T5orf172 domain; Region: T5orf172; pfam10544 167539001852 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 167539001853 Iron-sulfur protein interface; other site 167539001854 proximal heme binding site [chemical binding]; other site 167539001855 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 167539001856 L-aspartate oxidase; Provisional; Region: PRK06175 167539001857 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167539001858 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 167539001859 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 167539001860 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 167539001861 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 167539001862 AAA domain; Region: AAA_23; pfam13476 167539001863 Walker A/P-loop; other site 167539001864 ATP binding site [chemical binding]; other site 167539001865 Q-loop/lid; other site 167539001866 ABC transporter signature motif; other site 167539001867 Protein of unknown function (DUF342); Region: DUF342; cl19219 167539001868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539001869 Q-loop/lid; other site 167539001870 ABC transporter signature motif; other site 167539001871 Walker B; other site 167539001872 D-loop; other site 167539001873 H-loop/switch region; other site 167539001874 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 167539001875 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 167539001876 active site 167539001877 metal binding site [ion binding]; metal-binding site 167539001878 DNA binding site [nucleotide binding] 167539001879 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167539001880 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 167539001881 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 167539001882 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 167539001883 HsdM N-terminal domain; Region: HsdM_N; pfam12161 167539001884 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 167539001885 Methyltransferase domain; Region: Methyltransf_26; pfam13659 167539001886 short chain dehydrogenase; Region: adh_short; pfam00106 167539001887 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167539001888 NADP binding site [chemical binding]; other site 167539001889 homodimer interface [polypeptide binding]; other site 167539001890 active site 167539001891 DNA translocase FtsK; Provisional; Region: PRK10263 167539001892 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167539001893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167539001894 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539001895 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001896 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 167539001897 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167539001898 active site 167539001899 homodimer interface [polypeptide binding]; other site 167539001900 catalytic site [active] 167539001901 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 167539001902 mannosyl-3-phosphoglycerate phosphatase-related protein; Region: MPGP_rel; TIGR02463 167539001903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539001904 active site 167539001905 motif I; other site 167539001906 motif II; other site 167539001907 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167539001908 active site 167539001909 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 167539001910 T5orf172 domain; Region: T5orf172; pfam10544 167539001911 Bacitracin resistance protein BacA; Region: BacA; pfam02673 167539001912 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167539001913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539001914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167539001915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539001916 Walker A/P-loop; other site 167539001917 ATP binding site [chemical binding]; other site 167539001918 Q-loop/lid; other site 167539001919 ABC transporter signature motif; other site 167539001920 Walker B; other site 167539001921 D-loop; other site 167539001922 H-loop/switch region; other site 167539001923 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167539001924 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167539001925 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167539001926 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167539001927 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167539001928 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 167539001929 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167539001930 catalytic site [active] 167539001931 subunit interface [polypeptide binding]; other site 167539001932 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 167539001933 anti sigma factor interaction site; other site 167539001934 regulatory phosphorylation site [posttranslational modification]; other site 167539001935 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167539001936 active site 167539001937 metal binding site [ion binding]; metal-binding site 167539001938 dimerization interface [polypeptide binding]; other site 167539001939 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167539001940 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 167539001941 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167539001942 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167539001943 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 167539001944 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167539001945 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 167539001946 active site 167539001947 PHP Thumb interface [polypeptide binding]; other site 167539001948 metal binding site [ion binding]; metal-binding site 167539001949 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 167539001950 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 167539001951 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167539001952 generic binding surface I; other site 167539001953 generic binding surface II; other site 167539001954 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167539001955 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167539001956 16S/18S rRNA binding site [nucleotide binding]; other site 167539001957 S13e-L30e interaction site [polypeptide binding]; other site 167539001958 25S rRNA binding site [nucleotide binding]; other site 167539001959 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167539001960 RuvA N terminal domain; Region: RuvA_N; pfam01330 167539001961 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 167539001962 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167539001963 EamA-like transporter family; Region: EamA; pfam00892 167539001964 EamA-like transporter family; Region: EamA; pfam00892 167539001965 DNA primase; Validated; Region: dnaG; PRK05667 167539001966 CHC2 zinc finger; Region: zf-CHC2; pfam01807 167539001967 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167539001968 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167539001969 active site 167539001970 metal binding site [ion binding]; metal-binding site 167539001971 interdomain interaction site; other site 167539001972 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 167539001973 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167539001974 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167539001975 active site 167539001976 DNA binding site [nucleotide binding] 167539001977 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 167539001978 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167539001979 Catalytic site [active] 167539001980 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 167539001981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001982 S-adenosylmethionine binding site [chemical binding]; other site 167539001983 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167539001984 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167539001985 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167539001986 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167539001987 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167539001988 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167539001989 alpha subunit interface [polypeptide binding]; other site 167539001990 TPP binding site [chemical binding]; other site 167539001991 heterodimer interface [polypeptide binding]; other site 167539001992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539001993 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 167539001994 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167539001995 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 167539001996 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 167539001997 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167539001998 Protein export membrane protein; Region: SecD_SecF; pfam02355 167539001999 Domain of unknown function DUF20; Region: UPF0118; cl00465 167539002000 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 167539002001 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 167539002002 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 167539002003 active site residue [active] 167539002004 AAA domain; Region: AAA_18; pfam13238 167539002005 GUN4-like; Region: GUN4; pfam05419 167539002006 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 167539002007 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167539002008 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167539002009 active site 167539002010 catalytic site [active] 167539002011 substrate binding site [chemical binding]; other site 167539002012 Nodulation protein NolV; Region: NolV; pfam06635 167539002013 histidyl-tRNA synthetase; Region: hisS; TIGR00442 167539002014 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167539002015 dimer interface [polypeptide binding]; other site 167539002016 motif 1; other site 167539002017 active site 167539002018 motif 2; other site 167539002019 Syntaxin-like protein; Region: Syntaxin_2; pfam14523 167539002020 motif 3; other site 167539002021 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 167539002022 anticodon binding site; other site 167539002023 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 167539002024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 167539002025 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539002026 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 167539002027 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 167539002028 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167539002029 putative GSH binding site (G-site) [chemical binding]; other site 167539002030 active site cysteine [active] 167539002031 putative C-terminal domain interface [polypeptide binding]; other site 167539002032 putative dimer interface [polypeptide binding]; other site 167539002033 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 167539002034 putative N-terminal domain interface [polypeptide binding]; other site 167539002035 putative dimer interface [polypeptide binding]; other site 167539002036 putative substrate binding pocket (H-site) [chemical binding]; other site 167539002037 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 167539002038 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 167539002039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002040 NAD(P) binding site [chemical binding]; other site 167539002041 active site 167539002042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539002043 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167539002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002045 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 167539002046 NAD(P) binding site [chemical binding]; other site 167539002047 active site 167539002048 mechanosensitive channel MscS; Provisional; Region: PRK10334 167539002049 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167539002050 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 167539002051 catalytic triad [active] 167539002052 conserved cis-peptide bond; other site 167539002053 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167539002054 metal binding site 2 [ion binding]; metal-binding site 167539002055 putative DNA binding helix; other site 167539002056 metal binding site 1 [ion binding]; metal-binding site 167539002057 dimer interface [polypeptide binding]; other site 167539002058 structural Zn2+ binding site [ion binding]; other site 167539002059 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167539002060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002061 FeS/SAM binding site; other site 167539002062 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167539002063 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167539002064 Phosphotransferase enzyme family; Region: APH; pfam01636 167539002065 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 167539002066 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 167539002067 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167539002068 homodimer interface [polypeptide binding]; other site 167539002069 substrate-cofactor binding pocket; other site 167539002070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002071 catalytic residue [active] 167539002072 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 167539002073 proposed active site lysine [active] 167539002074 conserved cys residue [active] 167539002075 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 167539002076 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167539002077 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167539002078 Sulfate transporter family; Region: Sulfate_transp; cl19250 167539002079 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167539002080 FAD binding domain; Region: FAD_binding_4; cl19922 167539002081 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167539002082 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167539002083 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167539002084 putative active site [active] 167539002085 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167539002086 putative active site [active] 167539002087 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539002088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539002089 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167539002090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539002091 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167539002092 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002093 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539002094 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002095 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167539002096 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167539002097 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167539002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539002099 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167539002100 S-adenosylmethionine binding site [chemical binding]; other site 167539002101 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167539002102 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167539002103 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167539002104 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167539002105 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167539002106 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167539002107 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 167539002108 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167539002109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 167539002110 HlyD family secretion protein; Region: HlyD_3; pfam13437 167539002111 DevC protein; Region: devC; TIGR01185 167539002112 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167539002113 FtsX-like permease family; Region: FtsX; pfam02687 167539002114 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167539002115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167539002116 Walker A/P-loop; other site 167539002117 ATP binding site [chemical binding]; other site 167539002118 Q-loop/lid; other site 167539002119 ABC transporter signature motif; other site 167539002120 Walker B; other site 167539002121 D-loop; other site 167539002122 H-loop/switch region; other site 167539002123 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167539002124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167539002125 active site 167539002126 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167539002127 rRNA interaction site [nucleotide binding]; other site 167539002128 S8 interaction site; other site 167539002129 putative laminin-1 binding site; other site 167539002130 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167539002131 UBA/TS-N domain; Region: UBA; pfam00627 167539002132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 167539002133 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 167539002134 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167539002135 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167539002136 generic binding surface II; other site 167539002137 ssDNA binding site; other site 167539002138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539002139 ATP binding site [chemical binding]; other site 167539002140 putative Mg++ binding site [ion binding]; other site 167539002141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002142 nucleotide binding region [chemical binding]; other site 167539002143 ATP-binding site [chemical binding]; other site 167539002144 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 167539002145 sulfite reductase subunit beta; Provisional; Region: PRK13504 167539002146 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167539002147 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 167539002148 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167539002149 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 167539002150 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 167539002151 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167539002152 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 167539002153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539002154 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 167539002155 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 167539002156 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 167539002157 G1 box; other site 167539002158 putative GEF interaction site [polypeptide binding]; other site 167539002159 GTP/Mg2+ binding site [chemical binding]; other site 167539002160 Switch I region; other site 167539002161 G2 box; other site 167539002162 G3 box; other site 167539002163 Switch II region; other site 167539002164 G4 box; other site 167539002165 G5 box; other site 167539002166 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167539002167 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167539002168 Domain of unknown function (DUF309); Region: DUF309; pfam03745 167539002169 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167539002170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539002171 Walker A/P-loop; other site 167539002172 ATP binding site [chemical binding]; other site 167539002173 Q-loop/lid; other site 167539002174 ABC transporter signature motif; other site 167539002175 Walker B; other site 167539002176 D-loop; other site 167539002177 H-loop/switch region; other site 167539002178 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167539002179 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 167539002180 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167539002181 substrate binding site [chemical binding]; other site 167539002182 hexamer interface [polypeptide binding]; other site 167539002183 metal binding site [ion binding]; metal-binding site 167539002184 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167539002185 putative active site [active] 167539002186 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167539002187 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167539002188 tRNA; other site 167539002189 putative tRNA binding site [nucleotide binding]; other site 167539002190 putative NADP binding site [chemical binding]; other site 167539002191 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 167539002192 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167539002193 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167539002194 ligand binding site; other site 167539002195 oligomer interface; other site 167539002196 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167539002197 dimer interface [polypeptide binding]; other site 167539002198 N-terminal domain interface [polypeptide binding]; other site 167539002199 sulfate 1 binding site; other site 167539002200 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 167539002201 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167539002202 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167539002203 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167539002204 putative active site [active] 167539002205 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 167539002206 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 167539002207 DNA Topoisomerase I (eukaryota); Region: TOPEUc; smart00435 167539002208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167539002209 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539002210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002211 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002212 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167539002213 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 167539002214 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167539002215 chaperone protein DnaJ; Provisional; Region: PRK14297 167539002216 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 167539002217 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167539002218 putative active site [active] 167539002219 catalytic triad [active] 167539002220 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 167539002221 intersubunit interface [polypeptide binding]; other site 167539002222 active site 167539002223 zinc binding site [ion binding]; other site 167539002224 Na+ binding site [ion binding]; other site 167539002225 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 167539002226 active site 167539002227 intersubunit interface [polypeptide binding]; other site 167539002228 catalytic residue [active] 167539002229 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167539002230 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167539002231 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167539002232 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167539002233 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167539002234 active site 167539002235 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 167539002236 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167539002237 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167539002238 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167539002239 trimer interface [polypeptide binding]; other site 167539002240 active site 167539002241 UDP-GlcNAc binding site [chemical binding]; other site 167539002242 lipid binding site [chemical binding]; lipid-binding site 167539002243 gamma-glutamyl kinase; Provisional; Region: PRK05429 167539002244 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167539002245 nucleotide binding site [chemical binding]; other site 167539002246 homotetrameric interface [polypeptide binding]; other site 167539002247 putative phosphate binding site [ion binding]; other site 167539002248 putative allosteric binding site; other site 167539002249 PUA domain; Region: PUA; pfam01472 167539002250 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167539002251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539002252 active site 167539002253 motif I; other site 167539002254 motif II; other site 167539002255 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167539002256 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 167539002257 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 167539002258 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539002259 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167539002260 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167539002261 catalytic residues [active] 167539002262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002264 NAD(P) binding site [chemical binding]; other site 167539002265 active site 167539002266 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167539002267 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 167539002268 trimer interface [polypeptide binding]; other site 167539002269 putative Zn binding site [ion binding]; other site 167539002270 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167539002271 GSH binding site [chemical binding]; other site 167539002272 catalytic residues [active] 167539002273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539002274 Coenzyme A binding pocket [chemical binding]; other site 167539002275 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167539002276 NAD(P) binding site [chemical binding]; other site 167539002277 putative active site [active] 167539002278 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167539002279 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167539002280 minor groove reading motif; other site 167539002281 helix-hairpin-helix signature motif; other site 167539002282 substrate binding pocket [chemical binding]; other site 167539002283 active site 167539002284 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167539002285 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 167539002286 Walker A/P-loop; other site 167539002287 ATP binding site [chemical binding]; other site 167539002288 Q-loop/lid; other site 167539002289 ABC transporter signature motif; other site 167539002290 Walker B; other site 167539002291 D-loop; other site 167539002292 H-loop/switch region; other site 167539002293 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167539002294 Ferritin-like domain; Region: Ferritin; pfam00210 167539002295 ferroxidase diiron center [ion binding]; other site 167539002296 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167539002297 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 167539002298 putative switch regulator; other site 167539002299 non-specific DNA interactions [nucleotide binding]; other site 167539002300 DNA binding site [nucleotide binding] 167539002301 sequence specific DNA binding site [nucleotide binding]; other site 167539002302 putative cAMP binding site [chemical binding]; other site 167539002303 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539002304 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167539002305 transcription initiation factor IIB; Reviewed; Region: tfb; PRK00423 167539002306 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167539002307 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167539002308 Walker A/P-loop; other site 167539002309 ATP binding site [chemical binding]; other site 167539002310 Q-loop/lid; other site 167539002311 ABC transporter signature motif; other site 167539002312 Walker B; other site 167539002313 D-loop; other site 167539002314 H-loop/switch region; other site 167539002315 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167539002316 [2Fe-2S] cluster binding site [ion binding]; other site 167539002317 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167539002318 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539002319 L-asparaginase II; Region: Asparaginase_II; pfam06089 167539002320 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167539002321 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 167539002322 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167539002323 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167539002324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539002325 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167539002326 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 167539002327 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539002328 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167539002329 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167539002330 IMP binding site; other site 167539002331 dimer interface [polypeptide binding]; other site 167539002332 interdomain contacts; other site 167539002333 partial ornithine binding site; other site 167539002334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539002335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167539002336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539002337 Walker A/P-loop; other site 167539002338 ATP binding site [chemical binding]; other site 167539002339 Q-loop/lid; other site 167539002340 ABC transporter signature motif; other site 167539002341 Walker B; other site 167539002342 D-loop; other site 167539002343 H-loop/switch region; other site 167539002344 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539002345 RNA binding surface [nucleotide binding]; other site 167539002346 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167539002347 substrate binding site [chemical binding]; other site 167539002348 dimer interface [polypeptide binding]; other site 167539002349 catalytic triad [active] 167539002350 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 167539002351 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167539002352 substrate binding pocket [chemical binding]; other site 167539002353 dimer interface [polypeptide binding]; other site 167539002354 inhibitor binding site; inhibition site 167539002355 magnesium chelatase subunit H; Provisional; Region: PRK12493 167539002356 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002357 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167539002358 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 167539002359 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167539002360 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 167539002361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539002362 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167539002363 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167539002364 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167539002365 ABC transporter; Provisional; Region: PTZ00243 167539002366 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 167539002367 aspartate kinase III; Validated; Region: PRK09084 167539002368 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 167539002369 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 167539002370 Thf1-like protein; Reviewed; Region: PRK13266 167539002371 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 167539002372 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539002373 oligomer interface [polypeptide binding]; other site 167539002374 active site residues [active] 167539002375 cell division protein; Validated; Region: ftsH; CHL00176 167539002376 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539002377 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 167539002378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002379 Walker A motif; other site 167539002380 ATP binding site [chemical binding]; other site 167539002381 Walker B motif; other site 167539002382 arginine finger; other site 167539002383 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539002384 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167539002385 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167539002386 FtsX-like permease family; Region: FtsX; pfam02687 167539002387 pyruvate kinase; Provisional; Region: PRK06354 167539002388 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 167539002389 domain interfaces; other site 167539002390 active site 167539002391 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 167539002392 putative metal binding site [ion binding]; other site 167539002393 YGGT family; Region: YGGT; pfam02325 167539002394 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 167539002395 threonine dehydratase; Reviewed; Region: PRK09224 167539002396 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167539002397 tetramer interface [polypeptide binding]; other site 167539002398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002399 catalytic residue [active] 167539002400 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167539002401 putative Ile/Val binding site [chemical binding]; other site 167539002402 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167539002403 putative Ile/Val binding site [chemical binding]; other site 167539002404 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167539002405 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167539002406 TPP-binding site; other site 167539002407 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539002408 PYR/PP interface [polypeptide binding]; other site 167539002409 dimer interface [polypeptide binding]; other site 167539002410 TPP binding site [chemical binding]; other site 167539002411 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539002412 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 167539002413 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167539002414 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167539002415 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167539002416 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167539002417 catalytic triad [active] 167539002418 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 167539002419 heat shock protein 90; Provisional; Region: PRK05218 167539002420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539002421 ATP binding site [chemical binding]; other site 167539002422 Mg2+ binding site [ion binding]; other site 167539002423 G-X-G motif; other site 167539002424 Hsp90 protein; Region: HSP90; pfam00183 167539002425 Ferredoxin [Energy production and conversion]; Region: COG1146 167539002426 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 167539002427 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167539002428 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 167539002429 motif 1; other site 167539002430 dimer interface [polypeptide binding]; other site 167539002431 active site 167539002432 motif 2; other site 167539002433 motif 3; other site 167539002434 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167539002435 active site 167539002436 dimerization interface [polypeptide binding]; other site 167539002437 molecular chaperone DnaK; Provisional; Region: PRK13410 167539002438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167539002439 nucleotide binding site [chemical binding]; other site 167539002440 chaperone protein DnaJ; Provisional; Region: PRK14299 167539002441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539002442 HSP70 interaction site [polypeptide binding]; other site 167539002443 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167539002444 substrate binding site [polypeptide binding]; other site 167539002445 dimer interface [polypeptide binding]; other site 167539002446 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167539002447 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 167539002448 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 167539002449 putative active site [active] 167539002450 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167539002451 active site 167539002452 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167539002453 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 167539002454 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167539002455 dimerization interface [polypeptide binding]; other site 167539002456 active site 167539002457 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167539002458 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 167539002459 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 167539002460 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167539002461 active site 167539002462 substrate binding site [chemical binding]; other site 167539002463 cosubstrate binding site; other site 167539002464 catalytic site [active] 167539002465 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167539002466 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 167539002467 active site 167539002468 dimer interface [polypeptide binding]; other site 167539002469 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167539002470 dimer interface [polypeptide binding]; other site 167539002471 active site 167539002472 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167539002473 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167539002474 active site 167539002475 HIGH motif; other site 167539002476 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539002477 KMSKS motif; other site 167539002478 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167539002479 tRNA binding surface [nucleotide binding]; other site 167539002480 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167539002481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167539002482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167539002483 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167539002484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002485 catalytic residue [active] 167539002486 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167539002487 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167539002488 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167539002489 active site 167539002490 (T/H)XGH motif; other site 167539002491 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 167539002492 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167539002493 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167539002494 GIY-YIG motif/motif A; other site 167539002495 active site 167539002496 catalytic site [active] 167539002497 putative DNA binding site [nucleotide binding]; other site 167539002498 metal binding site [ion binding]; metal-binding site 167539002499 UvrB/uvrC motif; Region: UVR; pfam02151 167539002500 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167539002501 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 167539002502 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 167539002503 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 167539002504 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 167539002505 active site 167539002506 cobaltochelatase, CobN subunit; Region: cobalto_cobN; TIGR02257 167539002507 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002508 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167539002509 homodimer interface [polypeptide binding]; other site 167539002510 substrate-cofactor binding pocket; other site 167539002511 catalytic residue [active] 167539002512 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167539002513 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 167539002514 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 167539002515 substrate binding pocket [chemical binding]; other site 167539002516 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167539002517 B12 binding site [chemical binding]; other site 167539002518 cobalt ligand [ion binding]; other site 167539002519 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167539002520 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167539002521 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167539002522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539002523 HSP70 interaction site [polypeptide binding]; other site 167539002524 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 167539002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539002526 S-adenosylmethionine binding site [chemical binding]; other site 167539002527 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167539002528 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167539002529 putative tRNA-binding site [nucleotide binding]; other site 167539002530 B3/4 domain; Region: B3_4; pfam03483 167539002531 tRNA synthetase B5 domain; Region: B5; smart00874 167539002532 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167539002533 dimer interface [polypeptide binding]; other site 167539002534 motif 1; other site 167539002535 motif 3; other site 167539002536 motif 2; other site 167539002537 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 167539002538 ribosomal protein L33; Region: rpl33; CHL00104 167539002539 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 167539002540 RNB domain; Region: RNB; pfam00773 167539002541 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167539002542 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167539002543 active site 167539002544 HIGH motif; other site 167539002545 KMSKS motif; other site 167539002546 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167539002547 tRNA binding surface [nucleotide binding]; other site 167539002548 anticodon binding site; other site 167539002549 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 167539002550 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167539002551 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167539002552 homotrimer interface [polypeptide binding]; other site 167539002553 Walker A motif; other site 167539002554 GTP binding site [chemical binding]; other site 167539002555 Walker B motif; other site 167539002556 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 167539002557 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 167539002558 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167539002559 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167539002560 dimer interface [polypeptide binding]; other site 167539002561 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167539002562 catalytic triad [active] 167539002563 peroxidatic and resolving cysteines [active] 167539002564 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539002565 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167539002566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002567 Walker A motif; other site 167539002568 ATP binding site [chemical binding]; other site 167539002569 Walker B motif; other site 167539002570 arginine finger; other site 167539002571 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539002572 ribosomal protein L32; Validated; Region: rpl32; CHL00152 167539002573 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 167539002574 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 167539002575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539002576 motif II; other site 167539002577 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 167539002578 DHH family; Region: DHH; pfam01368 167539002579 DHHA1 domain; Region: DHHA1; pfam02272 167539002580 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 167539002581 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167539002582 Predicted membrane protein [Function unknown]; Region: COG2119 167539002583 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167539002584 Exoribonuclease R [Transcription]; Region: VacB; COG0557 167539002585 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 167539002586 RNB domain; Region: RNB; pfam00773 167539002587 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 167539002588 RNA binding site [nucleotide binding]; other site 167539002589 aromatic acid decarboxylase; Validated; Region: PRK05920 167539002590 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167539002591 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 167539002592 dinuclear metal binding motif [ion binding]; other site 167539002593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539002594 catalytic loop [active] 167539002595 iron binding site [ion binding]; other site 167539002596 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 167539002597 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167539002598 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167539002599 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167539002600 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167539002601 putative active site [active] 167539002602 substrate binding site [chemical binding]; other site 167539002603 putative cosubstrate binding site; other site 167539002604 catalytic site [active] 167539002605 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 167539002606 substrate binding site [chemical binding]; other site 167539002607 Integral membrane protein TerC family; Region: TerC; cl10468 167539002608 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167539002609 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 167539002610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539002611 ATP binding site [chemical binding]; other site 167539002612 putative Mg++ binding site [ion binding]; other site 167539002613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002614 nucleotide binding region [chemical binding]; other site 167539002615 ATP-binding site [chemical binding]; other site 167539002616 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 167539002617 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539002618 DoxX; Region: DoxX; pfam07681 167539002619 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 167539002620 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167539002621 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167539002622 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167539002623 active site 167539002624 dimer interface [polypeptide binding]; other site 167539002625 metal binding site [ion binding]; metal-binding site 167539002626 Uncharacterized conserved protein [Function unknown]; Region: COG1565 167539002627 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 167539002628 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 167539002629 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 167539002630 TIGR04168 family protein; Region: TIGR04168 167539002631 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 167539002632 quinolinate synthetase; Provisional; Region: PRK09375 167539002633 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 167539002634 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167539002635 protein binding site [polypeptide binding]; other site 167539002636 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167539002637 Catalytic dyad [active] 167539002638 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167539002639 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 167539002640 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167539002641 Fe-S cluster binding site [ion binding]; other site 167539002642 active site 167539002643 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 167539002644 aspartate aminotransferase; Provisional; Region: PRK05764 167539002645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002647 homodimer interface [polypeptide binding]; other site 167539002648 catalytic residue [active] 167539002649 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167539002650 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167539002651 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 167539002652 Walker A/P-loop; other site 167539002653 ATP binding site [chemical binding]; other site 167539002654 Q-loop/lid; other site 167539002655 ABC transporter signature motif; other site 167539002656 Walker B; other site 167539002657 D-loop; other site 167539002658 H-loop/switch region; other site 167539002659 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167539002660 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 167539002661 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167539002662 active site 167539002663 catalytic triad [active] 167539002664 oxyanion hole [active] 167539002665 Integral membrane protein DUF92; Region: DUF92; pfam01940 167539002666 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 167539002667 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167539002668 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539002669 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167539002670 Walker A/P-loop; other site 167539002671 ATP binding site [chemical binding]; other site 167539002672 Q-loop/lid; other site 167539002673 ABC transporter signature motif; other site 167539002674 Walker B; other site 167539002675 D-loop; other site 167539002676 H-loop/switch region; other site 167539002677 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167539002678 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167539002679 dimerization interface [polypeptide binding]; other site 167539002680 domain crossover interface; other site 167539002681 redox-dependent activation switch; other site 167539002682 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167539002683 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167539002684 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 167539002685 G1 box; other site 167539002686 putative GEF interaction site [polypeptide binding]; other site 167539002687 GTP/Mg2+ binding site [chemical binding]; other site 167539002688 Switch I region; other site 167539002689 G2 box; other site 167539002690 G3 box; other site 167539002691 Switch II region; other site 167539002692 G4 box; other site 167539002693 G5 box; other site 167539002694 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167539002695 Elongation Factor G, domain II; Region: EFG_II; pfam14492 167539002696 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167539002697 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 167539002698 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 167539002699 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167539002700 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167539002701 G1 box; other site 167539002702 GTP/Mg2+ binding site [chemical binding]; other site 167539002703 Switch I region; other site 167539002704 G2 box; other site 167539002705 Switch II region; other site 167539002706 G3 box; other site 167539002707 G4 box; other site 167539002708 G5 box; other site 167539002709 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167539002710 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 167539002711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002712 catalytic residue [active] 167539002713 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167539002714 nucleoside/Zn binding site; other site 167539002715 dimer interface [polypeptide binding]; other site 167539002716 catalytic motif [active] 167539002717 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167539002718 homodimer interface [polypeptide binding]; other site 167539002719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002720 catalytic residue [active] 167539002721 glutamine synthetase, type I; Region: GlnA; TIGR00653 167539002722 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167539002723 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167539002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539002725 S-adenosylmethionine binding site [chemical binding]; other site 167539002726 acetyl-CoA synthetase; Provisional; Region: PRK00174 167539002727 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 167539002728 active site 167539002729 CoA binding site [chemical binding]; other site 167539002730 acyl-activating enzyme (AAE) consensus motif; other site 167539002731 AMP binding site [chemical binding]; other site 167539002732 acetate binding site [chemical binding]; other site 167539002733 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167539002734 substrate binding pocket [chemical binding]; other site 167539002735 chain length determination region; other site 167539002736 substrate-Mg2+ binding site; other site 167539002737 catalytic residues [active] 167539002738 aspartate-rich region 1; other site 167539002739 active site lid residues [active] 167539002740 aspartate-rich region 2; other site 167539002741 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 167539002742 AMIN domain; Region: AMIN; pfam11741 167539002743 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 167539002744 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167539002745 active site 167539002746 metal binding site [ion binding]; metal-binding site 167539002747 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167539002748 putative active site [active] 167539002749 catalytic triad [active] 167539002750 dimer interface [polypeptide binding]; other site 167539002751 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 167539002752 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 167539002753 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 167539002754 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167539002755 hinge; other site 167539002756 active site 167539002757 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 167539002758 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 167539002759 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 167539002760 Substrate binding site; other site 167539002761 Mg++ binding site; other site 167539002762 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 167539002763 active site 167539002764 substrate binding site [chemical binding]; other site 167539002765 CoA binding site [chemical binding]; other site 167539002766 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 167539002767 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539002768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539002769 glycogen synthase; Provisional; Region: glgA; PRK00654 167539002770 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167539002771 ADP-binding pocket [chemical binding]; other site 167539002772 homodimer interface [polypeptide binding]; other site 167539002773 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 167539002774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167539002775 substrate binding site [chemical binding]; other site 167539002776 oxyanion hole (OAH) forming residues; other site 167539002777 trimer interface [polypeptide binding]; other site 167539002778 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167539002779 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 167539002780 dimer interface [polypeptide binding]; other site 167539002781 tetramer interface [polypeptide binding]; other site 167539002782 PYR/PP interface [polypeptide binding]; other site 167539002783 TPP binding site [chemical binding]; other site 167539002784 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167539002785 TPP-binding site; other site 167539002786 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167539002787 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539002788 Catalytic site [active] 167539002789 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167539002790 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167539002791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167539002792 ABC-ATPase subunit interface; other site 167539002793 dimer interface [polypeptide binding]; other site 167539002794 putative PBP binding regions; other site 167539002795 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167539002796 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167539002797 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 167539002798 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167539002799 metal binding site [ion binding]; metal-binding site 167539002800 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167539002801 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 167539002802 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167539002803 active site 167539002804 HIGH motif; other site 167539002805 dimer interface [polypeptide binding]; other site 167539002806 KMSKS motif; other site 167539002807 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167539002808 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167539002809 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167539002810 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167539002811 active site 167539002812 dimer interface [polypeptide binding]; other site 167539002813 motif 1; other site 167539002814 motif 2; other site 167539002815 motif 3; other site 167539002816 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167539002817 anticodon binding site; other site 167539002818 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 167539002819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 167539002820 nucleotide binding site [chemical binding]; other site 167539002821 homoserine kinase; Provisional; Region: PRK01212 167539002822 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167539002823 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167539002824 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167539002825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167539002826 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167539002827 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167539002828 active site 167539002829 Zn binding site [ion binding]; other site 167539002830 Putative lysophospholipase; Region: Hydrolase_4; cl19140 167539002831 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167539002832 Dihydroneopterin aldolase; Region: FolB; smart00905 167539002833 active site 167539002834 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167539002835 putative catalytic cysteine [active] 167539002836 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 167539002837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 167539002838 nucleotide binding site [chemical binding]; other site 167539002839 Family of unknown function (DUF490); Region: DUF490; pfam04357 167539002840 Protein of function (DUF2518); Region: DUF2518; pfam10726 167539002841 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167539002842 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 167539002843 Putative lysophospholipase; Region: Hydrolase_4; cl19140 167539002844 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 167539002845 glycogen branching enzyme; Provisional; Region: PRK05402 167539002846 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167539002847 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167539002848 active site 167539002849 catalytic site [active] 167539002850 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 167539002851 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167539002852 substrate binding site [chemical binding]; other site 167539002853 active site 167539002854 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539002855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002856 NAD(P) binding site [chemical binding]; other site 167539002857 active site 167539002858 Plastocyanin is a type I copper protein and functions in the electron transfer from PSII to PSI; Region: Plastocyanin; cd04219 167539002859 Type 1 (T1) Cu binding site [ion binding]; other site 167539002860 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167539002861 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002862 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002864 Walker A motif; other site 167539002865 ATP binding site [chemical binding]; other site 167539002866 Walker B motif; other site 167539002867 arginine finger; other site 167539002868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002869 Walker A motif; other site 167539002870 ATP binding site [chemical binding]; other site 167539002871 Walker B motif; other site 167539002872 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167539002873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167539002874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539002875 active site 167539002876 phosphorylation site [posttranslational modification] 167539002877 intermolecular recognition site; other site 167539002878 dimerization interface [polypeptide binding]; other site 167539002879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539002880 DNA binding site [nucleotide binding] 167539002881 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167539002882 putative GSH binding site [chemical binding]; other site 167539002883 catalytic residues [active] 167539002884 BolA-like protein; Region: BolA; pfam01722 167539002885 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167539002886 putative acyl-acceptor binding pocket; other site 167539002887 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 167539002888 active site 167539002889 hydrophilic channel; other site 167539002890 dimerization interface [polypeptide binding]; other site 167539002891 catalytic residues [active] 167539002892 active site lid [active] 167539002893 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 167539002894 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 167539002895 Phospholipid methyltransferase; Region: PEMT; cl17370 167539002896 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 167539002897 AAA domain; Region: AAA_22; pfam13401 167539002898 Part of AAA domain; Region: AAA_19; pfam13245 167539002899 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 167539002900 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167539002901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002902 Walker A motif; other site 167539002903 ATP binding site [chemical binding]; other site 167539002904 Walker B motif; other site 167539002905 arginine finger; other site 167539002906 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 167539002907 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 167539002908 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167539002909 ATP binding site [chemical binding]; other site 167539002910 Mg++ binding site [ion binding]; other site 167539002911 motif III; other site 167539002912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002913 nucleotide binding region [chemical binding]; other site 167539002914 ATP-binding site [chemical binding]; other site 167539002915 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 167539002916 putative RNA binding site [nucleotide binding]; other site 167539002917 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539002918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167539002919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539002920 Walker A/P-loop; other site 167539002921 ATP binding site [chemical binding]; other site 167539002922 Q-loop/lid; other site 167539002923 ABC transporter signature motif; other site 167539002924 Walker B; other site 167539002925 D-loop; other site 167539002926 H-loop/switch region; other site 167539002927 PsbP; Region: PsbP; pfam01789 167539002928 recombination protein RecR; Reviewed; Region: recR; PRK00076 167539002929 RecR protein; Region: RecR; pfam02132 167539002930 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167539002931 putative active site [active] 167539002932 putative metal-binding site [ion binding]; other site 167539002933 tetramer interface [polypeptide binding]; other site 167539002934 lipoyl synthase; Provisional; Region: PRK12928 167539002935 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 167539002936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002937 FeS/SAM binding site; other site 167539002938 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167539002939 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167539002940 active site residue [active] 167539002941 biotin synthase; Region: bioB; TIGR00433 167539002942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002943 FeS/SAM binding site; other site 167539002944 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 167539002945 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 167539002946 active site 167539002947 dimer interface [polypeptide binding]; other site 167539002948 Uncharacterized conserved protein [Function unknown]; Region: COG1624 167539002949 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167539002950 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167539002951 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167539002952 active site 167539002953 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539002954 substrate binding site [chemical binding]; other site 167539002955 catalytic residues [active] 167539002956 dimer interface [polypeptide binding]; other site 167539002957 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167539002958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539002959 Coenzyme A binding pocket [chemical binding]; other site 167539002960 Clp protease ATP binding subunit; Region: clpC; CHL00095 167539002961 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002962 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002964 Walker A motif; other site 167539002965 ATP binding site [chemical binding]; other site 167539002966 Walker B motif; other site 167539002967 arginine finger; other site 167539002968 UvrB/uvrC motif; Region: UVR; pfam02151 167539002969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002970 Walker A motif; other site 167539002971 ATP binding site [chemical binding]; other site 167539002972 Walker B motif; other site 167539002973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167539002974 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167539002975 putative active site [active] 167539002976 metal binding site [ion binding]; metal-binding site 167539002977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167539002978 phosphatidate cytidylyltransferase; Region: PLN02953 167539002979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 167539002980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002981 catalytic residue [active] 167539002982 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 167539002983 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 167539002984 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539002985 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167539002986 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539002987 RNA binding surface [nucleotide binding]; other site 167539002988 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 167539002989 active site 167539002990 Helix-turn-helix domain; Region: HTH_25; pfam13413 167539002991 Helper component proteinase; Region: Peptidase_C6; pfam00851 167539002992 4-alpha-glucanotransferase; Provisional; Region: PRK14508 167539002993 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 167539002994 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 167539002995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539002996 active site 167539002997 adaptive-response sensory kinase; Validated; Region: PRK09303 167539002998 KaiB domain; Region: KaiB; pfam07689 167539002999 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 167539003000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167539003001 dimer interface [polypeptide binding]; other site 167539003002 phosphorylation site [posttranslational modification] 167539003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539003004 ATP binding site [chemical binding]; other site 167539003005 Mg2+ binding site [ion binding]; other site 167539003006 G-X-G motif; other site 167539003007 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167539003008 hydrophobic ligand binding site; other site 167539003009 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167539003010 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167539003011 dimerization interface [polypeptide binding]; other site 167539003012 FAD binding pocket [chemical binding]; other site 167539003013 FAD binding motif [chemical binding]; other site 167539003014 catalytic residues [active] 167539003015 NAD binding pocket [chemical binding]; other site 167539003016 phosphate binding motif [ion binding]; other site 167539003017 beta-alpha-beta structure motif; other site 167539003018 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167539003019 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167539003020 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167539003021 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 167539003022 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167539003023 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167539003024 catalytic triad [active] 167539003025 AAA domain; Region: AAA_30; pfam13604 167539003026 AAA domain; Region: AAA_11; pfam13086 167539003027 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 167539003028 Divergent PAP2 family; Region: DUF212; pfam02681 167539003029 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167539003030 substrate binding pocket [chemical binding]; other site 167539003031 chain length determination region; other site 167539003032 substrate-Mg2+ binding site; other site 167539003033 catalytic residues [active] 167539003034 aspartate-rich region 1; other site 167539003035 active site lid residues [active] 167539003036 aspartate-rich region 2; other site 167539003037 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167539003038 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167539003039 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167539003040 homodimer interface [polypeptide binding]; other site 167539003041 NADP binding site [chemical binding]; other site 167539003042 substrate binding site [chemical binding]; other site 167539003043 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 167539003044 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 167539003045 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167539003046 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167539003047 Zn2+ binding site [ion binding]; other site 167539003048 Mg2+ binding site [ion binding]; other site 167539003049 putative methanogenesis marker protein 2; Region: methan_mark_2; TIGR03267 167539003050 2-isopropylmalate synthase; Validated; Region: PRK00915 167539003051 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167539003052 active site 167539003053 catalytic residues [active] 167539003054 metal binding site [ion binding]; metal-binding site 167539003055 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 167539003056 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167539003057 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 167539003058 active site 167539003059 substrate binding site [chemical binding]; other site 167539003060 catalytic site [active] 167539003061 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167539003062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539003063 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167539003064 DNA gyrase subunit A; Validated; Region: PRK05560 167539003065 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167539003066 CAP-like domain; other site 167539003067 active site 167539003068 primary dimer interface [polypeptide binding]; other site 167539003069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003074 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167539003075 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 167539003076 active site 167539003077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167539003078 catalytic residues [active] 167539003079 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167539003080 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 167539003081 putative active site [active] 167539003082 oxyanion strand; other site 167539003083 catalytic triad [active] 167539003084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003085 S-adenosylmethionine binding site [chemical binding]; other site 167539003086 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 167539003087 Cytochrome c; Region: Cytochrom_C; pfam00034 167539003088 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167539003089 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167539003090 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 167539003091 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 167539003092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539003093 Walker A motif; other site 167539003094 ATP binding site [chemical binding]; other site 167539003095 Walker B motif; other site 167539003096 arginine finger; other site 167539003097 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 167539003098 active site 167539003099 putative DNA-binding cleft [nucleotide binding]; other site 167539003100 dimer interface [polypeptide binding]; other site 167539003101 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 167539003102 Fe-S metabolizm associated domain; Region: SufE; cl00951 167539003103 homoserine dehydrogenase; Provisional; Region: PRK06349 167539003104 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 167539003105 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167539003106 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167539003107 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 167539003108 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 167539003109 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167539003110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539003111 dimer interface [polypeptide binding]; other site 167539003112 conserved gate region; other site 167539003113 putative PBP binding loops; other site 167539003114 ABC-ATPase subunit interface; other site 167539003115 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167539003116 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167539003117 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 167539003118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167539003119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539003120 putative substrate translocation pore; other site 167539003121 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167539003122 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 167539003123 substrate binding site [chemical binding]; other site 167539003124 ATP binding site [chemical binding]; other site 167539003125 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167539003126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003128 flavodoxin FldA; Validated; Region: PRK09267 167539003129 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539003130 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539003131 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539003132 putative high light inducible protein; Region: PHA02337 167539003133 putative high light inducible protein; Region: PHA02337 167539003134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539003135 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167539003136 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167539003137 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167539003138 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167539003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003140 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167539003141 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 167539003142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539003143 active site 167539003144 catalytic tetrad [active] 167539003145 Uncharacterized conserved protein [Function unknown]; Region: COG4095 167539003146 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167539003147 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167539003148 ABC transporter; Region: ABC_tran_2; pfam12848 167539003149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167539003150 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167539003151 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167539003152 Membrane transport protein; Region: Mem_trans; cl09117 167539003153 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 167539003154 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 167539003155 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 167539003156 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167539003157 putative di-iron ligands [ion binding]; other site 167539003158 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 167539003159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003160 active site 167539003161 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167539003162 putative di-iron ligands [ion binding]; other site 167539003163 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167539003164 Rhomboid family; Region: Rhomboid; cl11446 167539003165 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167539003166 catalytic residues [active] 167539003167 dimer interface [polypeptide binding]; other site 167539003168 hypothetical protein; Provisional; Region: PRK09256 167539003169 Ion channel; Region: Ion_trans_2; pfam07885 167539003170 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 167539003171 TrkA-N domain; Region: TrkA_N; pfam02254 167539003172 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 167539003173 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 167539003174 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 167539003175 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167539003176 GTP-binding protein YchF; Reviewed; Region: PRK09601 167539003177 YchF GTPase; Region: YchF; cd01900 167539003178 G1 box; other site 167539003179 GTP/Mg2+ binding site [chemical binding]; other site 167539003180 Switch I region; other site 167539003181 G2 box; other site 167539003182 Switch II region; other site 167539003183 G3 box; other site 167539003184 G4 box; other site 167539003185 G5 box; other site 167539003186 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167539003187 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167539003188 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 167539003189 HlyD family secretion protein; Region: HlyD_3; pfam13437 167539003190 DNA polymerase I; Provisional; Region: PRK05755 167539003191 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167539003192 active site 167539003193 metal binding site 1 [ion binding]; metal-binding site 167539003194 putative 5' ssDNA interaction site; other site 167539003195 metal binding site 3; metal-binding site 167539003196 metal binding site 2 [ion binding]; metal-binding site 167539003197 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167539003198 putative DNA binding site [nucleotide binding]; other site 167539003199 putative metal binding site [ion binding]; other site 167539003200 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167539003201 active site 167539003202 catalytic site [active] 167539003203 substrate binding site [chemical binding]; other site 167539003204 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167539003205 active site 167539003206 DNA binding site [nucleotide binding] 167539003207 catalytic site [active] 167539003208 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167539003209 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167539003210 active site 167539003211 HIGH motif; other site 167539003212 KMSKS motif; other site 167539003213 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167539003214 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167539003215 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167539003216 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167539003217 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 167539003218 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 167539003219 dimer interface [polypeptide binding]; other site 167539003220 [2Fe-2S] cluster binding site [ion binding]; other site 167539003221 Putative lysophospholipase; Region: Hydrolase_4; cl19140 167539003222 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 167539003223 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167539003224 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167539003225 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 167539003226 ligand binding site [chemical binding]; other site 167539003227 homodimer interface [polypeptide binding]; other site 167539003228 NAD(P) binding site [chemical binding]; other site 167539003229 trimer interface B [polypeptide binding]; other site 167539003230 trimer interface A [polypeptide binding]; other site 167539003231 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167539003232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539003233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539003234 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539003235 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167539003236 rRNA binding site [nucleotide binding]; other site 167539003237 predicted 30S ribosome binding site; other site 167539003238 Ycf39; Provisional; Region: ycf39; CHL00194 167539003239 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167539003240 NAD(P) binding site [chemical binding]; other site 167539003241 putative active site [active] 167539003242 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 167539003243 Putative lysophospholipase; Region: Hydrolase_4; cl19140 167539003244 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167539003245 Serine carboxypeptidase S28; Region: Peptidase_S28; cl19554 167539003246 Putative lysophospholipase; Region: Hydrolase_4; cl19140 167539003247 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 167539003248 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167539003249 putative valine binding site [chemical binding]; other site 167539003250 dimer interface [polypeptide binding]; other site 167539003251 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167539003252 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167539003253 active site 167539003254 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 167539003255 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 167539003256 pheophytin binding site; other site 167539003257 chlorophyll binding site; other site 167539003258 quinone binding site; other site 167539003259 Fe binding site [ion binding]; other site 167539003260 Photosystem II protein; Region: PSII; cl08223 167539003261 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167539003262 active site 167539003263 dimer interface [polypeptide binding]; other site 167539003264 cobyric acid synthase; Provisional; Region: PRK00784 167539003265 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167539003266 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167539003267 catalytic triad [active] 167539003268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539003269 catalytic loop [active] 167539003270 iron binding site [ion binding]; other site 167539003271 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167539003272 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 167539003273 CotH protein; Region: CotH; cl19892 167539003274 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 167539003275 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 167539003276 putative metal binding residues [ion binding]; other site 167539003277 signature motif; other site 167539003278 dimer interface [polypeptide binding]; other site 167539003279 active site 167539003280 polyP binding site; other site 167539003281 substrate binding site [chemical binding]; other site 167539003282 acceptor-phosphate pocket; other site 167539003283 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 167539003284 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167539003285 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 167539003286 dimer interface [polypeptide binding]; other site 167539003287 motif 1; other site 167539003288 active site 167539003289 motif 2; other site 167539003290 motif 3; other site 167539003291 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 167539003292 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 167539003293 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 167539003294 DEAD-like helicases superfamily; Region: DEXDc; smart00487 167539003295 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167539003296 Z1 domain; Region: Z1; pfam10593 167539003297 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 167539003298 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167539003299 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 167539003300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539003301 motif II; other site 167539003302 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 167539003303 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167539003304 TPP-binding site [chemical binding]; other site 167539003305 dimer interface [polypeptide binding]; other site 167539003306 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 167539003307 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539003308 PYR/PP interface [polypeptide binding]; other site 167539003309 dimer interface [polypeptide binding]; other site 167539003310 TPP binding site [chemical binding]; other site 167539003311 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539003312 extended (e) SDRs; Region: SDR_e; cd08946 167539003313 NAD(P) binding site [chemical binding]; other site 167539003314 active site 167539003315 substrate binding site [chemical binding]; other site 167539003316 sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324 167539003317 sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323 167539003318 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167539003319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539003320 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 167539003321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167539003322 UDP-galactopyranose mutase; Region: GLF; pfam03275 167539003323 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539003324 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 167539003325 Cupin domain; Region: Cupin_2; cl17218 167539003326 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 167539003327 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167539003328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167539003330 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167539003331 EamA-like transporter family; Region: EamA; pfam00892 167539003332 EamA-like transporter family; Region: EamA; pfam00892 167539003333 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 167539003334 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167539003335 tandem repeat interface [polypeptide binding]; other site 167539003336 oligomer interface [polypeptide binding]; other site 167539003337 active site residues [active] 167539003338 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167539003339 homotrimer interaction site [polypeptide binding]; other site 167539003340 active site 167539003341 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167539003342 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 167539003343 Ribonuclease P; Region: Ribonuclease_P; cl00457 167539003344 Bacterial PH domain; Region: bPH_2; pfam03703 167539003345 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167539003346 Ycf46; Provisional; Region: ycf46; CHL00195 167539003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539003348 Walker A motif; other site 167539003349 ATP binding site [chemical binding]; other site 167539003350 Walker B motif; other site 167539003351 arginine finger; other site 167539003352 seryl-tRNA synthetase; Provisional; Region: PRK05431 167539003353 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167539003354 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 167539003355 dimer interface [polypeptide binding]; other site 167539003356 active site 167539003357 motif 1; other site 167539003358 motif 2; other site 167539003359 motif 3; other site 167539003360 RIP metalloprotease RseP; Region: TIGR00054 167539003361 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167539003362 active site 167539003363 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 167539003364 protein binding site [polypeptide binding]; other site 167539003365 putative substrate binding region [chemical binding]; other site 167539003366 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 167539003367 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167539003368 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 167539003369 RNase E interface [polypeptide binding]; other site 167539003370 trimer interface [polypeptide binding]; other site 167539003371 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167539003372 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 167539003373 RNase E interface [polypeptide binding]; other site 167539003374 trimer interface [polypeptide binding]; other site 167539003375 active site 167539003376 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167539003377 putative nucleic acid binding region [nucleotide binding]; other site 167539003378 G-X-X-G motif; other site 167539003379 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539003380 RNA binding site [nucleotide binding]; other site 167539003381 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 167539003382 active site 167539003383 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 167539003384 putative SAM binding site [chemical binding]; other site 167539003385 putative homodimer interface [polypeptide binding]; other site 167539003386 Helix-turn-helix domain; Region: HTH_28; pfam13518 167539003387 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 167539003388 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167539003389 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167539003390 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 167539003391 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167539003392 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003393 NAD binding site [chemical binding]; other site 167539003394 putative substrate binding site 2 [chemical binding]; other site 167539003395 putative substrate binding site 1 [chemical binding]; other site 167539003396 active site 167539003397 UDP-glucose 4-epimerase; Region: PLN02240 167539003398 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167539003399 NAD binding site [chemical binding]; other site 167539003400 homodimer interface [polypeptide binding]; other site 167539003401 active site 167539003402 substrate binding site [chemical binding]; other site 167539003403 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003404 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167539003405 putative NAD(P) binding site [chemical binding]; other site 167539003406 active site 167539003407 putative substrate binding site [chemical binding]; other site 167539003408 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 167539003409 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 167539003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 167539003411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539003412 Polynucleotide kinase 3 phosphatase; Region: PNK3P; pfam08645 167539003413 active site 167539003414 motif I; other site 167539003415 motif II; other site 167539003416 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 167539003417 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167539003418 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167539003419 active site 167539003420 Substrate binding site; other site 167539003421 Mg++ binding site; other site 167539003422 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 167539003423 dimer interface [polypeptide binding]; other site 167539003424 active site 167539003425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539003426 active site 167539003427 nucleotide binding site [chemical binding]; other site 167539003428 HIGH motif; other site 167539003429 KMSKS motif; other site 167539003430 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 167539003431 putative ribose interaction site [chemical binding]; other site 167539003432 putative ADP binding site [chemical binding]; other site 167539003433 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003434 extended (e) SDRs; Region: SDR_e; cd08946 167539003435 NAD(P) binding site [chemical binding]; other site 167539003436 active site 167539003437 substrate binding site [chemical binding]; other site 167539003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539003440 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167539003441 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003442 active site 167539003443 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167539003444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003445 active site 167539003446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003447 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 167539003448 putative ADP-binding pocket [chemical binding]; other site 167539003449 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167539003450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003451 active site 167539003452 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167539003453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003454 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 167539003455 Chain length determinant protein; Region: Wzz; pfam02706 167539003456 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539003457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539003458 Walker A/P-loop; other site 167539003459 ATP binding site [chemical binding]; other site 167539003460 Q-loop/lid; other site 167539003461 ABC transporter signature motif; other site 167539003462 Walker B; other site 167539003463 D-loop; other site 167539003464 H-loop/switch region; other site 167539003465 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 167539003466 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 167539003467 SOS regulatory protein LexA; Region: lexA; TIGR00498 167539003468 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 167539003469 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167539003470 Catalytic site [active] 167539003471 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167539003472 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167539003473 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167539003474 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539003475 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167539003476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539003477 Walker A motif; other site 167539003478 ATP binding site [chemical binding]; other site 167539003479 Walker B motif; other site 167539003480 arginine finger; other site 167539003481 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539003482 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167539003483 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167539003484 catalytic motif [active] 167539003485 Zn binding site [ion binding]; other site 167539003486 RibD C-terminal domain; Region: RibD_C; cl17279 167539003487 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167539003488 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 167539003489 active site 167539003490 putative homodimer interface [polypeptide binding]; other site 167539003491 SAM binding site [chemical binding]; other site 167539003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539003493 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 167539003494 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 167539003495 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 167539003496 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167539003497 dimer interface [polypeptide binding]; other site 167539003498 motif 1; other site 167539003499 active site 167539003500 motif 2; other site 167539003501 motif 3; other site 167539003502 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 167539003503 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167539003504 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167539003505 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167539003506 active site 167539003507 Riboflavin kinase; Region: Flavokinase; smart00904 167539003508 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167539003509 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167539003510 thiamine phosphate binding site [chemical binding]; other site 167539003511 active site 167539003512 pyrophosphate binding site [ion binding]; other site 167539003513 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167539003514 thiS-thiF/thiG interaction site; other site 167539003515 AIR carboxylase; Region: AIRC; smart01001 167539003516 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167539003517 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 167539003518 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167539003519 homotrimer interaction site [polypeptide binding]; other site 167539003520 zinc binding site [ion binding]; other site 167539003521 CDP-binding sites; other site 167539003522 GTPase Era; Reviewed; Region: era; PRK00089 167539003523 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 167539003524 G1 box; other site 167539003525 GTP/Mg2+ binding site [chemical binding]; other site 167539003526 Switch I region; other site 167539003527 G2 box; other site 167539003528 Switch II region; other site 167539003529 G3 box; other site 167539003530 G4 box; other site 167539003531 G5 box; other site 167539003532 KH domain; Region: KH_2; pfam07650 167539003533 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 167539003534 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 167539003535 PhoH-like protein; Region: PhoH; pfam02562 167539003536 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 167539003537 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 167539003538 signal recognition particle protein; Provisional; Region: PRK10867 167539003539 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 167539003540 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167539003541 P loop; other site 167539003542 GTP binding site [chemical binding]; other site 167539003543 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167539003544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 167539003545 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 167539003546 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167539003547 tetramer interface [polypeptide binding]; other site 167539003548 TPP-binding site [chemical binding]; other site 167539003549 heterodimer interface [polypeptide binding]; other site 167539003550 phosphorylation loop region [posttranslational modification] 167539003551 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539003552 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539003553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539003554 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539003555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539003556 DNA binding residues [nucleotide binding] 167539003557 Uncharacterized conserved protein [Function unknown]; Region: COG0062 167539003558 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167539003559 putative substrate binding site [chemical binding]; other site 167539003560 putative ATP binding site [chemical binding]; other site 167539003561 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 167539003562 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167539003563 Ligand Binding Site [chemical binding]; other site 167539003564 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167539003565 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167539003566 putative active site [active] 167539003567 catalytic triad [active] 167539003568 putative dimer interface [polypeptide binding]; other site 167539003569 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 167539003570 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167539003571 superoxide dismutase, Ni; Region: sodN; TIGR02753 167539003572 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539003573 Catalytic site [active] 167539003574 High-affinity nickel-transport protein; Region: NicO; cl00964 167539003575 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167539003576 active site 167539003577 ribulose/triose binding site [chemical binding]; other site 167539003578 phosphate binding site [ion binding]; other site 167539003579 substrate (anthranilate) binding pocket [chemical binding]; other site 167539003580 product (indole) binding pocket [chemical binding]; other site 167539003581 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167539003582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539003583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539003584 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 167539003585 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 167539003586 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167539003587 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167539003588 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 167539003589 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167539003590 hinge; other site 167539003591 active site 167539003592 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539003593 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 167539003594 inhibitor-cofactor binding pocket; inhibition site 167539003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539003596 catalytic residue [active] 167539003597 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167539003598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539003599 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167539003600 FAD binding domain; Region: FAD_binding_4; pfam01565 167539003601 cytosine deaminase-like protein; Validated; Region: PRK07583 167539003602 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167539003603 active site 167539003604 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167539003605 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167539003606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539003607 FeS/SAM binding site; other site 167539003608 TRAM domain; Region: TRAM; pfam01938 167539003609 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167539003610 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167539003611 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 167539003612 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 167539003613 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 167539003614 cell division protein FtsZ; Validated; Region: PRK09330 167539003615 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167539003616 nucleotide binding site [chemical binding]; other site 167539003617 SulA interaction site; other site 167539003618 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167539003619 oligomerization interface [polypeptide binding]; other site 167539003620 active site 167539003621 metal binding site [ion binding]; metal-binding site 167539003622 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167539003623 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 167539003624 HemN C-terminal domain; Region: HemN_C; pfam06969 167539003625 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 167539003626 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 167539003627 putative active site [active] 167539003628 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539003629 oligomer interface [polypeptide binding]; other site 167539003630 active site residues [active] 167539003631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539003632 oligomer interface [polypeptide binding]; other site 167539003633 active site residues [active] 167539003634 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167539003635 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 167539003636 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167539003637 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 167539003638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 167539003639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003640 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 167539003641 putative ADP-binding pocket [chemical binding]; other site 167539003642 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167539003643 light-harvesting-like protein 3; Provisional; Region: PLN00014 167539003644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539003645 active site 167539003646 nucleotide binding site [chemical binding]; other site 167539003647 HIGH motif; other site 167539003648 KMSKS motif; other site 167539003649 histone-like DNA-binding protein HU; Region: HU; cd13831 167539003650 dimer interface [polypeptide binding]; other site 167539003651 DNA binding site [nucleotide binding] 167539003652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167539003653 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 167539003654 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167539003655 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167539003656 active site 167539003657 catalytic site [active] 167539003658 MFS/sugar transport protein; Region: MFS_2; pfam13347 167539003659 putative symporter YagG; Provisional; Region: PRK09669; cl15392 167539003660 Permease; Region: Permease; pfam02405 167539003661 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167539003662 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167539003663 membrane protein; Provisional; Region: PRK14419 167539003664 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 167539003665 active site 167539003666 dimer interface [polypeptide binding]; other site 167539003667 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 167539003668 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167539003669 active site 167539003670 HIGH motif; other site 167539003671 dimer interface [polypeptide binding]; other site 167539003672 KMSKS motif; other site 167539003673 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167539003674 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 167539003675 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167539003676 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167539003677 interface (dimer of trimers) [polypeptide binding]; other site 167539003678 Substrate-binding/catalytic site; other site 167539003679 Zn-binding sites [ion binding]; other site 167539003680 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 167539003681 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167539003682 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 167539003683 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167539003684 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167539003685 active site 167539003686 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167539003687 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 167539003688 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167539003689 chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992 167539003690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167539003691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167539003692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167539003693 Surface antigen; Region: Bac_surface_Ag; pfam01103 167539003694 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167539003695 ATP binding site [chemical binding]; other site 167539003696 active site 167539003697 substrate binding site [chemical binding]; other site 167539003698 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167539003699 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167539003700 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 167539003701 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167539003702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 167539003703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167539003704 dimerization interface [polypeptide binding]; other site 167539003705 PAS domain; Region: PAS; smart00091 167539003706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167539003707 dimer interface [polypeptide binding]; other site 167539003708 phosphorylation site [posttranslational modification] 167539003709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539003710 ATP binding site [chemical binding]; other site 167539003711 Mg2+ binding site [ion binding]; other site 167539003712 G-X-G motif; other site 167539003713 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 167539003714 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167539003715 Walker A motif; other site 167539003716 ATP binding site [chemical binding]; other site 167539003717 Walker B motif; other site 167539003718 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167539003719 Walker A motif; other site 167539003720 ATP binding site [chemical binding]; other site 167539003721 Walker B motif; other site 167539003722 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167539003723 tetramer interface [polypeptide binding]; other site 167539003724 dimer interface [polypeptide binding]; other site 167539003725 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 167539003726 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 167539003727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003728 S-adenosylmethionine binding site [chemical binding]; other site 167539003729 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167539003730 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 167539003731 RNA binding site [nucleotide binding]; other site 167539003732 active site 167539003733 Stage II sporulation protein; Region: SpoIID; pfam08486 167539003734 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167539003735 ribonuclease Z; Region: RNase_Z; TIGR02651 167539003736 cytochrome c-550; Provisional; Region: psbV; cl17239 167539003737 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167539003738 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003739 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539003741 catalytic loop [active] 167539003742 iron binding site [ion binding]; other site 167539003743 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167539003744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003745 S-adenosylmethionine binding site [chemical binding]; other site 167539003746 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167539003747 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 167539003748 ligand binding site [chemical binding]; other site 167539003749 NAD binding site [chemical binding]; other site 167539003750 dimerization interface [polypeptide binding]; other site 167539003751 catalytic site [active] 167539003752 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167539003753 putative L-serine binding site [chemical binding]; other site 167539003754 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167539003755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539003756 RNA binding surface [nucleotide binding]; other site 167539003757 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167539003758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539003759 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539003760 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539003761 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167539003762 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003763 active site 167539003764 Uncharacterized conserved protein [Function unknown]; Region: COG4095 167539003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167539003766 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167539003767 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167539003768 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167539003769 catalytic triad [active] 167539003770 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 167539003771 Na2 binding site [ion binding]; other site 167539003772 putative substrate binding site 1 [chemical binding]; other site 167539003773 Na binding site 1 [ion binding]; other site 167539003774 putative substrate binding site 2 [chemical binding]; other site 167539003775 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167539003776 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 167539003777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539003778 catalytic residue [active] 167539003779 flagellar capping protein; Validated; Region: fliD; PRK08724 167539003780 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539003781 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 167539003782 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 167539003783 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167539003784 Protein of unknown function (DUF938); Region: DUF938; pfam06080 167539003785 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167539003786 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539003787 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 167539003788 putative active site [active] 167539003789 EamA-like transporter family; Region: EamA; pfam00892 167539003790 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 167539003791 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167539003792 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 167539003793 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167539003794 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167539003795 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 167539003796 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167539003797 Protein of unknown function; Region: DUF3721; pfam12518 167539003798 Protein of unknown function; Region: DUF3721; pfam12518 167539003799 GLTT repeat (6 copies); Region: GLTT; pfam01744 167539003800 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 167539003801 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167539003802 ABC-ATPase subunit interface; other site 167539003803 dimer interface [polypeptide binding]; other site 167539003804 putative PBP binding regions; other site 167539003805 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167539003806 metal binding site 2 [ion binding]; metal-binding site 167539003807 putative DNA binding helix; other site 167539003808 metal binding site 1 [ion binding]; metal-binding site 167539003809 dimer interface [polypeptide binding]; other site 167539003810 structural Zn2+ binding site [ion binding]; other site 167539003811 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539003812 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167539003813 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167539003814 intersubunit interface [polypeptide binding]; other site 167539003815 Periplasmic solute binding protein family; Region: TroA; pfam01297 167539003816 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167539003817 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167539003818 P-loop, Walker A motif; other site 167539003819 Base recognition motif; other site 167539003820 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167539003821 FOG: WD40 repeat [General function prediction only]; Region: COG2319 167539003822 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 167539003823 structural tetrad; other site 167539003824 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167539003825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167539003826 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167539003827 putative high light inducible protein; Region: PHA02337 167539003828 putative high light inducible protein; Region: PHA02337 167539003829 putative high light inducible protein; Region: PHA02337 167539003830 putative high light inducible protein; Region: PHA02337 167539003831 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; cl19499 167539003832 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 167539003833 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167539003834 Ion transport protein; Region: Ion_trans; pfam00520 167539003835 Ion channel; Region: Ion_trans_2; pfam07885 167539003836 putative high light inducible protein; Region: PHA02337 167539003837 Protein of unknown function, DUF481; Region: DUF481; pfam04338 167539003838 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 167539003839 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167539003840 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 167539003841 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167539003842 short chain dehydrogenase; Region: adh_short; pfam00106 167539003843 putative NAD(P) binding site [chemical binding]; other site 167539003844 active site 167539003845 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 167539003846 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 167539003847 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 167539003848 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167539003849 hinge; other site 167539003850 active site 167539003851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167539003852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539003853 active site 167539003854 phosphorylation site [posttranslational modification] 167539003855 intermolecular recognition site; other site 167539003856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539003857 DNA binding residues [nucleotide binding] 167539003858 dimerization interface [polypeptide binding]; other site 167539003859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167539003860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539003861 ATP binding site [chemical binding]; other site 167539003862 Mg2+ binding site [ion binding]; other site 167539003863 G-X-G motif; other site 167539003864 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 167539003865 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167539003866 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 167539003867 OsmC-like protein; Region: OsmC; pfam02566 167539003868 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 167539003869 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 167539003870 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 167539003871 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 167539003872 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167539003873 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539003874 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 167539003875 active site 167539003876 metal binding site [ion binding]; metal-binding site 167539003877 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 167539003878 Beta-lactamase; Region: Beta-lactamase; pfam00144 167539003879 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167539003880 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 167539003881 ligand binding site [chemical binding]; other site 167539003882 flexible hinge region; other site 167539003883 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167539003884 putative switch regulator; other site 167539003885 non-specific DNA interactions [nucleotide binding]; other site 167539003886 DNA binding site [nucleotide binding] 167539003887 sequence specific DNA binding site [nucleotide binding]; other site 167539003888 putative cAMP binding site [chemical binding]; other site 167539003889 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 167539003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167539003891 putative substrate translocation pore; other site 167539003892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539003893 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167539003894 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167539003895 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167539003896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 167539003897 dimerization interface [polypeptide binding]; other site 167539003898 putative DNA binding site [nucleotide binding]; other site 167539003899 putative Zn2+ binding site [ion binding]; other site 167539003900 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 167539003901 active site 167539003902 EVE domain; Region: EVE; cl00728 167539003903 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539003904 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167539003905 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167539003906 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 167539003907 nucleotide binding site [chemical binding]; other site 167539003908 putative NEF/HSP70 interaction site [polypeptide binding]; other site 167539003909 SBD interface [polypeptide binding]; other site 167539003910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003911 active site 167539003912 phosphoglyceromutase; Provisional; Region: PRK05434 167539003913 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 167539003914 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167539003915 ring oligomerisation interface [polypeptide binding]; other site 167539003916 ATP/Mg binding site [chemical binding]; other site 167539003917 stacking interactions; other site 167539003918 hinge regions; other site 167539003919 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167539003920 oligomerisation interface [polypeptide binding]; other site 167539003921 mobile loop; other site 167539003922 roof hairpin; other site 167539003923 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167539003924 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167539003925 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167539003926 alpha subunit interaction interface [polypeptide binding]; other site 167539003927 Walker A motif; other site 167539003928 ATP binding site [chemical binding]; other site 167539003929 Walker B motif; other site 167539003930 inhibitor binding site; inhibition site 167539003931 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167539003932 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167539003933 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 167539003934 gamma subunit interface [polypeptide binding]; other site 167539003935 epsilon subunit interface [polypeptide binding]; other site 167539003936 LBP interface [polypeptide binding]; other site 167539003937 hypothetical protein; Provisional; Region: PRK02724 167539003938 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167539003939 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 167539003940 proline aminopeptidase P II; Provisional; Region: PRK10879 167539003941 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 167539003942 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167539003943 active site 167539003944 Domain of unknown function DUF21; Region: DUF21; pfam01595 167539003945 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167539003946 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167539003947 G1 box; other site 167539003948 GTP/Mg2+ binding site [chemical binding]; other site 167539003949 Switch I region; other site 167539003950 G2 box; other site 167539003951 Switch II region; other site 167539003952 G3 box; other site 167539003953 G4 box; other site 167539003954 G5 box; other site 167539003955 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167539003956 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167539003957 active site 167539003958 (T/H)XGH motif; other site 167539003959 NAD synthetase; Provisional; Region: PRK13981 167539003960 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167539003961 multimer interface [polypeptide binding]; other site 167539003962 active site 167539003963 catalytic triad [active] 167539003964 protein interface 1 [polypeptide binding]; other site 167539003965 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167539003966 homodimer interface [polypeptide binding]; other site 167539003967 NAD binding pocket [chemical binding]; other site 167539003968 ATP binding pocket [chemical binding]; other site 167539003969 Mg binding site [ion binding]; other site 167539003970 active-site loop [active] 167539003971 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 167539003972 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 167539003973 hexamer interface [polypeptide binding]; other site 167539003974 ligand binding site [chemical binding]; other site 167539003975 putative active site [active] 167539003976 NAD(P) binding site [chemical binding]; other site 167539003977 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167539003978 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 167539003979 core domain interface [polypeptide binding]; other site 167539003980 delta subunit interface [polypeptide binding]; other site 167539003981 epsilon subunit interface [polypeptide binding]; other site 167539003982 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167539003983 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167539003984 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167539003985 beta subunit interaction interface [polypeptide binding]; other site 167539003986 Walker A motif; other site 167539003987 ATP binding site [chemical binding]; other site 167539003988 Walker B motif; other site 167539003989 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167539003990 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 167539003991 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167539003992 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 167539003993 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167539003994 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 167539003995 ATP synthase CF0 C subunit; Region: atpH; CHL00061 167539003996 ATP synthase CF0 A subunit; Region: atpI; CHL00046 167539003997 ATP synthase I chain; Region: ATP_synt_I; pfam03899 167539003998 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 167539003999 Sulfite exporter TauE/SafE; Region: TauE; cl19196 167539004000 ResB-like family; Region: ResB; pfam05140 167539004001 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 167539004002 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 167539004003 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167539004004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539004005 RNA binding surface [nucleotide binding]; other site 167539004006 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 167539004007 adenylosuccinate lyase; Provisional; Region: PRK07380 167539004008 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167539004009 tetramer interface [polypeptide binding]; other site 167539004010 active site 167539004011 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 167539004012 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167539004013 Class II fumarases; Region: Fumarase_classII; cd01362 167539004014 active site 167539004015 tetramer interface [polypeptide binding]; other site 167539004016 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167539004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539004018 ATP binding site [chemical binding]; other site 167539004019 putative Mg++ binding site [ion binding]; other site 167539004020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539004021 nucleotide binding region [chemical binding]; other site 167539004022 ATP-binding site [chemical binding]; other site 167539004023 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167539004024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 167539004025 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 167539004026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539004027 catalytic residue [active] 167539004028 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167539004029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539004030 S-adenosylmethionine binding site [chemical binding]; other site 167539004031 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 167539004032 AAA domain; Region: AAA_26; pfam13500 167539004033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539004034 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 167539004035 inhibitor-cofactor binding pocket; inhibition site 167539004036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004037 catalytic residue [active] 167539004038 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 167539004039 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539004040 HSP70 interaction site [polypeptide binding]; other site 167539004041 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 167539004042 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167539004043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539004044 active site 167539004045 catalytic tetrad [active] 167539004046 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 167539004047 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 167539004048 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 167539004049 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167539004050 HEAT repeats; Region: HEAT_2; pfam13646 167539004051 HEAT-like repeat; Region: HEAT_EZ; pfam13513 167539004052 HEAT repeats; Region: HEAT_2; pfam13646 167539004053 HEAT-like repeat; Region: HEAT_EZ; pfam13513 167539004054 HEAT repeats; Region: HEAT_2; pfam13646 167539004055 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 167539004056 Na binding site [ion binding]; other site 167539004057 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 167539004058 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167539004059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004060 FeS/SAM binding site; other site 167539004061 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 167539004062 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167539004063 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167539004064 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167539004065 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167539004066 DNA binding site [nucleotide binding] 167539004067 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167539004068 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167539004069 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 167539004070 large subunit interface [polypeptide binding]; other site 167539004071 clamp; other site 167539004072 Zn-binding [ion binding]; other site 167539004073 active site region [active] 167539004074 catalytic site [active] 167539004075 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167539004076 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167539004077 RPB12 interaction site [polypeptide binding]; other site 167539004078 RPB1 interaction site [polypeptide binding]; other site 167539004079 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 167539004080 RPB10 interaction site [polypeptide binding]; other site 167539004081 RPB11 interaction site [polypeptide binding]; other site 167539004082 RPB3 interaction site [polypeptide binding]; other site 167539004083 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167539004084 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 167539004085 active site 167539004086 ribosomal protein S20; Region: rps20; CHL00102 167539004087 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167539004088 histidinol dehydrogenase; Region: hisD; TIGR00069 167539004089 NAD binding site [chemical binding]; other site 167539004090 dimerization interface [polypeptide binding]; other site 167539004091 product binding site; other site 167539004092 substrate binding site [chemical binding]; other site 167539004093 zinc binding site [ion binding]; other site 167539004094 catalytic residues [active] 167539004095 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167539004096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539004097 active site 167539004098 dimer interface [polypeptide binding]; other site 167539004099 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167539004100 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167539004101 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167539004102 protein binding site [polypeptide binding]; other site 167539004103 Sm and related proteins; Region: Sm_like; cl00259 167539004104 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 167539004105 NusA N-terminal domain; Region: NusA_N; pfam08529 167539004106 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539004107 RNA binding site [nucleotide binding]; other site 167539004108 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167539004109 G-X-X-G motif; other site 167539004110 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167539004111 G-X-X-G motif; other site 167539004112 Protein of unknown function (DUF448); Region: DUF448; pfam04296 167539004113 putative RNA binding cleft [nucleotide binding]; other site 167539004114 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 167539004115 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167539004116 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167539004117 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 167539004118 G1 box; other site 167539004119 putative GEF interaction site [polypeptide binding]; other site 167539004120 GTP/Mg2+ binding site [chemical binding]; other site 167539004121 Switch I region; other site 167539004122 G2 box; other site 167539004123 G3 box; other site 167539004124 Switch II region; other site 167539004125 G4 box; other site 167539004126 G5 box; other site 167539004127 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167539004128 Translation-initiation factor 2; Region: IF-2; pfam11987 167539004129 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167539004130 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167539004131 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 167539004132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004133 FeS/SAM binding site; other site 167539004134 CAAX protease self-immunity; Region: Abi; pfam02517 167539004135 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 167539004136 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 167539004137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539004138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004139 homodimer interface [polypeptide binding]; other site 167539004140 catalytic residue [active] 167539004141 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 167539004142 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167539004143 B12 binding site [chemical binding]; other site 167539004144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004145 FeS/SAM binding site; other site 167539004146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 167539004147 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 167539004148 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167539004149 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167539004150 homodimer interface [polypeptide binding]; other site 167539004151 oligonucleotide binding site [chemical binding]; other site 167539004152 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 167539004153 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167539004154 RNA/DNA hybrid binding site [nucleotide binding]; other site 167539004155 active site 167539004156 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167539004157 prephenate dehydratase; Provisional; Region: PRK11898 167539004158 Prephenate dehydratase; Region: PDT; pfam00800 167539004159 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167539004160 putative L-Phe binding site [chemical binding]; other site 167539004161 tocopherol O-methyltransferase; Region: PLN02244 167539004162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539004163 S-adenosylmethionine binding site [chemical binding]; other site 167539004164 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167539004165 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 167539004166 elongation factor Tu; Reviewed; Region: PRK00049 167539004167 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 167539004168 G1 box; other site 167539004169 GEF interaction site [polypeptide binding]; other site 167539004170 GTP/Mg2+ binding site [chemical binding]; other site 167539004171 Switch I region; other site 167539004172 G2 box; other site 167539004173 G3 box; other site 167539004174 Switch II region; other site 167539004175 G4 box; other site 167539004176 G5 box; other site 167539004177 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167539004178 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167539004179 Antibiotic Binding Site [chemical binding]; other site 167539004180 elongation factor G; Reviewed; Region: PRK00007 167539004181 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 167539004182 G1 box; other site 167539004183 putative GEF interaction site [polypeptide binding]; other site 167539004184 GTP/Mg2+ binding site [chemical binding]; other site 167539004185 Switch I region; other site 167539004186 G2 box; other site 167539004187 G3 box; other site 167539004188 Switch II region; other site 167539004189 G4 box; other site 167539004190 G5 box; other site 167539004191 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167539004192 Elongation Factor G, domain II; Region: EFG_II; pfam14492 167539004193 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167539004194 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167539004195 30S ribosomal protein S7; Validated; Region: PRK05302 167539004196 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167539004197 S17 interaction site [polypeptide binding]; other site 167539004198 S8 interaction site; other site 167539004199 16S rRNA interaction site [nucleotide binding]; other site 167539004200 streptomycin interaction site [chemical binding]; other site 167539004201 23S rRNA interaction site [nucleotide binding]; other site 167539004202 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167539004203 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167539004204 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167539004205 active site 167539004206 dimer interface [polypeptide binding]; other site 167539004207 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167539004208 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167539004209 active site 167539004210 FMN binding site [chemical binding]; other site 167539004211 substrate binding site [chemical binding]; other site 167539004212 3Fe-4S cluster binding site [ion binding]; other site 167539004213 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167539004214 domain interface; other site 167539004215 YCII-related domain; Region: YCII; cl00999 167539004216 lipoyl synthase; Provisional; Region: PRK05481 167539004217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004218 FeS/SAM binding site; other site 167539004219 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167539004220 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167539004221 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 167539004222 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 167539004223 active site 167539004224 SAM binding site [chemical binding]; other site 167539004225 homodimer interface [polypeptide binding]; other site 167539004226 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 167539004227 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 167539004228 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 167539004229 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 167539004230 NlpC/P60 family; Region: NLPC_P60; pfam00877 167539004231 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167539004232 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167539004233 Ligand binding site; other site 167539004234 Putative Catalytic site; other site 167539004235 DXD motif; other site 167539004236 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 167539004237 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 167539004238 alanine racemase; Reviewed; Region: alr; PRK00053 167539004239 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167539004240 active site 167539004241 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539004242 dimer interface [polypeptide binding]; other site 167539004243 substrate binding site [chemical binding]; other site 167539004244 catalytic residues [active] 167539004245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167539004246 active site 167539004247 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167539004248 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167539004249 RF-1 domain; Region: RF-1; pfam00472 167539004250 ribosomal protein L31; Validated; Region: rpl31; CHL00136 167539004251 ribosomal protein S9; Region: rps9; CHL00079 167539004252 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167539004253 23S rRNA interface [nucleotide binding]; other site 167539004254 L3 interface [polypeptide binding]; other site 167539004255 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167539004256 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 167539004257 dimerization interface 3.5A [polypeptide binding]; other site 167539004258 active site 167539004259 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 167539004260 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167539004261 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167539004262 alphaNTD homodimer interface [polypeptide binding]; other site 167539004263 alphaNTD - beta interaction site [polypeptide binding]; other site 167539004264 alphaNTD - beta' interaction site [polypeptide binding]; other site 167539004265 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 167539004266 30S ribosomal protein S11; Validated; Region: PRK05309 167539004267 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 167539004268 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 167539004269 adenylate kinase; Provisional; Region: PRK14531 167539004270 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167539004271 AMP-binding site [chemical binding]; other site 167539004272 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167539004273 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167539004274 SecY translocase; Region: SecY; pfam00344 167539004275 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 167539004276 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167539004277 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167539004278 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167539004279 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167539004280 5S rRNA interface [nucleotide binding]; other site 167539004281 L27 interface [polypeptide binding]; other site 167539004282 23S rRNA interface [nucleotide binding]; other site 167539004283 L5 interface [polypeptide binding]; other site 167539004284 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167539004285 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167539004286 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167539004287 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 167539004288 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167539004289 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167539004290 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167539004291 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 167539004292 RNA binding site [nucleotide binding]; other site 167539004293 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 167539004294 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 167539004295 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167539004296 putative translocon interaction site; other site 167539004297 23S rRNA interface [nucleotide binding]; other site 167539004298 signal recognition particle (SRP54) interaction site; other site 167539004299 L23 interface [polypeptide binding]; other site 167539004300 trigger factor interaction site; other site 167539004301 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167539004302 23S rRNA interface [nucleotide binding]; other site 167539004303 5S rRNA interface [nucleotide binding]; other site 167539004304 putative antibiotic binding site [chemical binding]; other site 167539004305 L25 interface [polypeptide binding]; other site 167539004306 L27 interface [polypeptide binding]; other site 167539004307 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167539004308 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167539004309 G-X-X-G motif; other site 167539004310 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167539004311 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167539004312 putative translocon binding site; other site 167539004313 protein-rRNA interface [nucleotide binding]; other site 167539004314 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 167539004315 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167539004316 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167539004317 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167539004318 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 167539004319 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 167539004320 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 167539004321 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167539004322 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 167539004323 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167539004324 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167539004325 recombinase A; Provisional; Region: recA; PRK09354 167539004326 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167539004327 hexamer interface [polypeptide binding]; other site 167539004328 Walker A motif; other site 167539004329 ATP binding site [chemical binding]; other site 167539004330 Walker B motif; other site 167539004331 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167539004332 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 167539004333 arogenate dehydrogenase; Reviewed; Region: PRK07417 167539004334 prephenate dehydrogenase; Validated; Region: PRK08507 167539004335 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 167539004336 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167539004337 Fructosamine kinase; Region: Fructosamin_kin; cl17579 167539004338 Phosphotransferase enzyme family; Region: APH; pfam01636 167539004339 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase; Region: CAAD; pfam14159 167539004340 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 167539004341 MPN+ (JAMM) motif; other site 167539004342 Zinc-binding site [ion binding]; other site 167539004343 hypothetical protein; Validated; Region: PRK07411 167539004344 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167539004345 ATP binding site [chemical binding]; other site 167539004346 substrate interface [chemical binding]; other site 167539004347 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167539004348 active site residue [active] 167539004349 hypothetical protein; Validated; Region: PRK07413 167539004350 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 167539004351 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 167539004352 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167539004353 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167539004354 Ligand Binding Site [chemical binding]; other site 167539004355 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 167539004356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539004357 recombination protein F; Reviewed; Region: recF; PRK00064 167539004358 Walker A/P-loop; other site 167539004359 ATP binding site [chemical binding]; other site 167539004360 Q-loop/lid; other site 167539004361 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 167539004362 ABC transporter signature motif; other site 167539004363 Walker B; other site 167539004364 D-loop; other site 167539004365 H-loop/switch region; other site 167539004366 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 167539004367 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167539004368 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167539004369 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167539004370 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167539004371 PsaD; Region: PsaD; pfam02531 167539004372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167539004373 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 167539004374 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 167539004375 Domain of unknown function DUF59; Region: DUF59; pfam01883 167539004376 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 167539004377 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167539004378 Walker A motif; other site 167539004379 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 167539004380 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167539004381 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167539004382 catalytic site [active] 167539004383 putative active site [active] 167539004384 putative substrate binding site [chemical binding]; other site 167539004385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167539004386 conserved hypothetical protein; Region: TIGR03492 167539004387 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167539004388 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167539004389 dimerization interface [polypeptide binding]; other site 167539004390 putative ATP binding site [chemical binding]; other site 167539004391 Pantoate-beta-alanine ligase; Region: PanC; cd00560 167539004392 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167539004393 active site 167539004394 ATP-binding site [chemical binding]; other site 167539004395 pantoate-binding site; other site 167539004396 HXXH motif; other site 167539004397 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167539004398 AAA domain; Region: AAA_18; pfam13238 167539004399 CMP-binding site; other site 167539004400 The sites determining sugar specificity; other site 167539004401 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167539004402 active site 167539004403 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249 167539004404 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 167539004405 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167539004406 heme binding pocket [chemical binding]; other site 167539004407 heme ligand [chemical binding]; other site 167539004408 isocitrate dehydrogenase; Validated; Region: PRK07362 167539004409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 167539004410 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 167539004411 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 167539004412 active site 167539004413 substrate binding site [chemical binding]; other site 167539004414 FMN binding site [chemical binding]; other site 167539004415 putative catalytic residues [active] 167539004416 D-lactate dehydrogenase; Provisional; Region: PRK11183 167539004417 FAD binding domain; Region: FAD_binding_4; cl19922 167539004418 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 167539004419 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167539004420 active site 167539004421 catalytic residues [active] 167539004422 hydrolase, alpha/beta fold family protein; Region: PLN02824 167539004423 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 167539004424 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167539004425 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167539004426 homodimer interface [polypeptide binding]; other site 167539004427 active site pocket [active] 167539004428 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 167539004429 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167539004430 dimerization interface [polypeptide binding]; other site 167539004431 active site 167539004432 metal binding site [ion binding]; metal-binding site 167539004433 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167539004434 dsRNA binding site [nucleotide binding]; other site 167539004435 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167539004436 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167539004437 RimM N-terminal domain; Region: RimM; pfam01782 167539004438 PRC-barrel domain; Region: PRC; pfam05239 167539004439 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167539004440 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167539004441 Substrate binding site; other site 167539004442 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 167539004443 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167539004444 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167539004445 glutaminase active site [active] 167539004446 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167539004447 dimer interface [polypeptide binding]; other site 167539004448 active site 167539004449 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167539004450 dimer interface [polypeptide binding]; other site 167539004451 active site 167539004452 photosystem I iron-sulfur protein PsaC; Region: PS_I_psaC; TIGR03048 167539004453 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 167539004454 acyl carrier protein; Provisional; Region: acpP; PRK00982 167539004455 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167539004456 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167539004457 dimer interface [polypeptide binding]; other site 167539004458 active site 167539004459 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167539004460 transketolase; Region: PLN02790 167539004461 TPP-binding site [chemical binding]; other site 167539004462 dimer interface [polypeptide binding]; other site 167539004463 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539004464 PYR/PP interface [polypeptide binding]; other site 167539004465 dimer interface [polypeptide binding]; other site 167539004466 TPP binding site [chemical binding]; other site 167539004467 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539004468 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 167539004469 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 167539004470 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 167539004471 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 167539004472 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167539004473 metal binding site [ion binding]; metal-binding site 167539004474 dimer interface [polypeptide binding]; other site 167539004475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004476 binding surface 167539004477 TPR motif; other site 167539004478 TPR repeat; Region: TPR_11; pfam13414 167539004479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004480 binding surface 167539004481 TPR motif; other site 167539004482 TPR repeat; Region: TPR_11; pfam13414 167539004483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004484 binding surface 167539004485 TPR motif; other site 167539004486 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167539004487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004488 Walker A motif; other site 167539004489 ATP binding site [chemical binding]; other site 167539004490 Walker B motif; other site 167539004491 arginine finger; other site 167539004492 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167539004493 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167539004494 SmpB-tmRNA interface; other site 167539004495 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167539004496 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167539004497 dimer interface [polypeptide binding]; other site 167539004498 putative anticodon binding site; other site 167539004499 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167539004500 motif 1; other site 167539004501 active site 167539004502 motif 2; other site 167539004503 motif 3; other site 167539004504 Ycf27; Reviewed; Region: orf27; CHL00148 167539004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539004506 active site 167539004507 phosphorylation site [posttranslational modification] 167539004508 intermolecular recognition site; other site 167539004509 dimerization interface [polypeptide binding]; other site 167539004510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539004511 DNA binding site [nucleotide binding] 167539004512 rod shape-determining protein MreC; Provisional; Region: PRK13922 167539004513 rod shape-determining protein MreB; Provisional; Region: PRK13927 167539004514 MreB and similar proteins; Region: MreB_like; cd10225 167539004515 nucleotide binding site [chemical binding]; other site 167539004516 Mg binding site [ion binding]; other site 167539004517 putative protofilament interaction site [polypeptide binding]; other site 167539004518 RodZ interaction site [polypeptide binding]; other site 167539004519 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167539004520 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167539004521 dimer interface [polypeptide binding]; other site 167539004522 ssDNA binding site [nucleotide binding]; other site 167539004523 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539004524 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 167539004525 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167539004526 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 167539004527 homotetramer interface [polypeptide binding]; other site 167539004528 ligand binding site [chemical binding]; other site 167539004529 catalytic site [active] 167539004530 NAD binding site [chemical binding]; other site 167539004531 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 167539004532 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167539004533 putative substrate binding site [chemical binding]; other site 167539004534 putative ATP binding site [chemical binding]; other site 167539004535 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 167539004536 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167539004537 minor groove reading motif; other site 167539004538 helix-hairpin-helix signature motif; other site 167539004539 substrate binding pocket [chemical binding]; other site 167539004540 active site 167539004541 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 167539004542 active site 167539004543 8-oxo-dGMP binding site [chemical binding]; other site 167539004544 nudix motif; other site 167539004545 metal binding site [ion binding]; metal-binding site 167539004546 hydrolase, alpha/beta fold family protein; Region: PLN02824 167539004547 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539004548 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539004549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539004550 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539004551 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 167539004552 DNA binding residues [nucleotide binding] 167539004553 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167539004554 MgtE intracellular N domain; Region: MgtE_N; smart00924 167539004555 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167539004556 Divalent cation transporter; Region: MgtE; pfam01769 167539004557 CrcB-like protein; Region: CRCB; pfam02537 167539004558 CrcB-like protein; Region: CRCB; pfam02537 167539004559 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167539004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539004561 ATP binding site [chemical binding]; other site 167539004562 Mg2+ binding site [ion binding]; other site 167539004563 G-X-G motif; other site 167539004564 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167539004565 anchoring element; other site 167539004566 dimer interface [polypeptide binding]; other site 167539004567 ATP binding site [chemical binding]; other site 167539004568 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167539004569 active site 167539004570 putative metal-binding site [ion binding]; other site 167539004571 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167539004572 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 167539004573 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167539004574 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167539004575 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167539004576 Predicted transcriptional regulators [Transcription]; Region: COG1725 167539004577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167539004578 DNA-binding site [nucleotide binding]; DNA binding site 167539004579 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 167539004580 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 167539004581 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167539004582 trimer interface [polypeptide binding]; other site 167539004583 active site 167539004584 substrate binding site [chemical binding]; other site 167539004585 CoA binding site [chemical binding]; other site 167539004586 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167539004587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539004588 ATP binding site [chemical binding]; other site 167539004589 putative Mg++ binding site [ion binding]; other site 167539004590 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 167539004591 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 167539004592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539004593 Coenzyme A binding pocket [chemical binding]; other site 167539004594 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167539004595 homopentamer interface [polypeptide binding]; other site 167539004596 active site 167539004597 YCF9; Region: Ycf9; cl09269 167539004598 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167539004599 MutS domain I; Region: MutS_I; pfam01624 167539004600 MutS domain II; Region: MutS_II; pfam05188 167539004601 MutS domain III; Region: MutS_III; pfam05192 167539004602 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 167539004603 Walker A/P-loop; other site 167539004604 ATP binding site [chemical binding]; other site 167539004605 Q-loop/lid; other site 167539004606 ABC transporter signature motif; other site 167539004607 Walker B; other site 167539004608 D-loop; other site 167539004609 H-loop/switch region; other site 167539004610 Precorrin-8X methylmutase; Region: CbiC; pfam02570 167539004611 DNA polymerase III subunit delta; Validated; Region: PRK07452 167539004612 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 167539004613 aspartate kinase; Provisional; Region: PRK07431 167539004614 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167539004615 putative nucleotide binding site [chemical binding]; other site 167539004616 putative catalytic residues [active] 167539004617 putative Mg ion binding site [ion binding]; other site 167539004618 putative aspartate binding site [chemical binding]; other site 167539004619 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167539004620 putative allosteric regulatory site; other site 167539004621 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 167539004622 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167539004623 putative allosteric regulatory site; other site 167539004624 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167539004625 putative allosteric regulatory residue; other site 167539004626 excinuclease ABC subunit B; Provisional; Region: PRK05298 167539004627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539004628 ATP binding site [chemical binding]; other site 167539004629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539004630 nucleotide binding region [chemical binding]; other site 167539004631 ATP-binding site [chemical binding]; other site 167539004632 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167539004633 UvrB/uvrC motif; Region: UVR; pfam02151 167539004634 Protein of unknown function (DUF561); Region: DUF561; pfam04481 167539004635 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 167539004636 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167539004637 Ligand Binding Site [chemical binding]; other site 167539004638 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167539004639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 167539004640 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 167539004641 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167539004642 dimer interface [polypeptide binding]; other site 167539004643 active site 167539004644 catalytic residue [active] 167539004645 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167539004646 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 167539004647 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 167539004648 trigger factor; Provisional; Region: tig; PRK01490 167539004649 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 167539004650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167539004651 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167539004652 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539004653 oligomer interface [polypeptide binding]; other site 167539004654 active site residues [active] 167539004655 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167539004656 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 167539004657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004658 Walker A motif; other site 167539004659 ATP binding site [chemical binding]; other site 167539004660 Walker B motif; other site 167539004661 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167539004662 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167539004663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004664 Walker A motif; other site 167539004665 ATP binding site [chemical binding]; other site 167539004666 Walker B motif; other site 167539004667 arginine finger; other site 167539004668 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167539004669 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 167539004670 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167539004671 DXD motif; other site 167539004672 Stage II sporulation protein; Region: SpoIID; pfam08486 167539004673 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167539004674 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 167539004675 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167539004676 23S rRNA binding site [nucleotide binding]; other site 167539004677 L21 binding site [polypeptide binding]; other site 167539004678 L13 binding site [polypeptide binding]; other site 167539004679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004680 binding surface 167539004681 TPR motif; other site 167539004682 TPR repeat; Region: TPR_11; pfam13414 167539004683 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167539004684 ThiS interaction site; other site 167539004685 putative active site [active] 167539004686 tetramer interface [polypeptide binding]; other site 167539004687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004688 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539004689 NAD(P) binding site [chemical binding]; other site 167539004690 active site 167539004691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539004692 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167539004693 glycine dehydrogenase; Provisional; Region: PRK05367 167539004694 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167539004695 tetramer interface [polypeptide binding]; other site 167539004696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004697 catalytic residue [active] 167539004698 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167539004699 tetramer interface [polypeptide binding]; other site 167539004700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004701 catalytic residue [active] 167539004702 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167539004703 lipoyl attachment site [posttranslational modification]; other site 167539004704 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 167539004705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539004706 catalytic residue [active] 167539004707 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167539004708 Di-iron ligands [ion binding]; other site 167539004709 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167539004710 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167539004711 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167539004712 replicative DNA helicase; Region: DnaB; TIGR00665 167539004713 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167539004714 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167539004715 Walker A motif; other site 167539004716 ATP binding site [chemical binding]; other site 167539004717 Walker B motif; other site 167539004718 DNA binding loops [nucleotide binding] 167539004719 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167539004720 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 167539004721 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167539004722 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 167539004723 Protein of unknown function (DUF98); Region: DUF98; pfam01947 167539004724 SprT-like family; Region: SprT-like; pfam10263 167539004725 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 167539004726 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 167539004727 nucleotide binding pocket [chemical binding]; other site 167539004728 K-X-D-G motif; other site 167539004729 catalytic site [active] 167539004730 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 167539004731 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 167539004732 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 167539004733 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 167539004734 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 167539004735 Dimer interface [polypeptide binding]; other site 167539004736 BRCT sequence motif; other site 167539004737 Uncharacterized conserved protein [Function unknown]; Region: COG0398 167539004738 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167539004739 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167539004740 active site 167539004741 HIGH motif; other site 167539004742 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539004743 KMSKS motif; other site 167539004744 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167539004745 tRNA binding surface [nucleotide binding]; other site 167539004746 anticodon binding site; other site 167539004747 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167539004748 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 167539004749 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 167539004750 homodimer interface [polypeptide binding]; other site 167539004751 metal binding site [ion binding]; metal-binding site 167539004752 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 167539004753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539004754 S-adenosylmethionine binding site [chemical binding]; other site 167539004755 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 167539004756 putative active site [active] 167539004757 Mn binding site [ion binding]; other site 167539004758 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167539004759 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 167539004760 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167539004761 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167539004762 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167539004763 dimer interface [polypeptide binding]; other site 167539004764 anticodon binding site; other site 167539004765 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 167539004766 homodimer interface [polypeptide binding]; other site 167539004767 motif 1; other site 167539004768 active site 167539004769 motif 2; other site 167539004770 GAD domain; Region: GAD; pfam02938 167539004771 motif 3; other site 167539004772 CTP synthetase; Validated; Region: pyrG; PRK05380 167539004773 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167539004774 Catalytic site [active] 167539004775 active site 167539004776 UTP binding site [chemical binding]; other site 167539004777 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167539004778 active site 167539004779 putative oxyanion hole; other site 167539004780 catalytic triad [active] 167539004781 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167539004782 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 167539004783 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167539004784 Ligand Binding Site [chemical binding]; other site 167539004785 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167539004786 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167539004787 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167539004788 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 167539004789 homodimer interface [polypeptide binding]; other site 167539004790 substrate-cofactor binding pocket; other site 167539004791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004792 catalytic residue [active] 167539004793 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 167539004794 active site 167539004795 SAM binding site [chemical binding]; other site 167539004796 homodimer interface [polypeptide binding]; other site 167539004797 hypothetical protein; Provisional; Region: PRK07394 167539004798 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167539004799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167539004800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167539004801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539004802 putative substrate translocation pore; other site 167539004803 polyphosphate kinase; Provisional; Region: PRK05443 167539004804 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 167539004805 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 167539004806 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 167539004807 putative active site [active] 167539004808 catalytic site [active] 167539004809 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167539004810 putative domain interface [polypeptide binding]; other site 167539004811 putative active site [active] 167539004812 catalytic site [active] 167539004813 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539004814 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539004815 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539004816 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539004817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539004818 DNA binding residues [nucleotide binding] 167539004819 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 167539004820 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 167539004821 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167539004822 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 167539004823 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167539004824 substrate binding site [chemical binding]; other site 167539004825 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167539004826 substrate binding site [chemical binding]; other site 167539004827 ligand binding site [chemical binding]; other site 167539004828 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167539004829 Cl- selectivity filter; other site 167539004830 Cl- binding residues [ion binding]; other site 167539004831 pore gating glutamate residue; other site 167539004832 dimer interface [polypeptide binding]; other site 167539004833 H+/Cl- coupling transport residue; other site 167539004834 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 167539004835 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167539004836 B12 binding site [chemical binding]; other site 167539004837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004838 FeS/SAM binding site; other site 167539004839 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 167539004840 O-Antigen ligase; Region: Wzy_C; pfam04932 167539004841 FAD dependent oxidoreductase; Region: DAO; pfam01266 167539004842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 167539004843 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167539004844 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 167539004845 nucleotide binding site [chemical binding]; other site 167539004846 NEF interaction site [polypeptide binding]; other site 167539004847 SBD interface [polypeptide binding]; other site 167539004848 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167539004849 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167539004850 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167539004851 shikimate binding site; other site 167539004852 NAD(P) binding site [chemical binding]; other site 167539004853 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 167539004854 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 167539004855 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167539004856 ANP binding site [chemical binding]; other site 167539004857 Substrate Binding Site II [chemical binding]; other site 167539004858 Substrate Binding Site I [chemical binding]; other site 167539004859 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 167539004860 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167539004861 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167539004862 Mg++ binding site [ion binding]; other site 167539004863 putative catalytic motif [active] 167539004864 putative substrate binding site [chemical binding]; other site 167539004865 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167539004866 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167539004867 putative ADP-binding pocket [chemical binding]; other site 167539004868 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167539004869 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167539004870 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167539004871 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 167539004872 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167539004873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167539004874 Walker A/P-loop; other site 167539004875 ATP binding site [chemical binding]; other site 167539004876 Q-loop/lid; other site 167539004877 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 167539004878 ABC transporter signature motif; other site 167539004879 Walker B; other site 167539004880 D-loop; other site 167539004881 H-loop/switch region; other site 167539004882 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539004883 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 167539004884 active site 167539004885 ATP binding site [chemical binding]; other site 167539004886 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167539004887 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167539004888 homodimer interface [polypeptide binding]; other site 167539004889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004890 catalytic residue [active]