-- dump date 20140620_000041 -- class Genbank::misc_feature -- table misc_feature_note -- id note 93059000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 93059000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 93059000003 putative DNA binding surface [nucleotide binding]; other site 93059000004 dimer interface [polypeptide binding]; other site 93059000005 beta-clamp/clamp loader binding surface; other site 93059000006 beta-clamp/translesion DNA polymerase binding surface; other site 93059000007 PRC-barrel domain; Region: PRC; pfam05239 93059000008 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 93059000009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 93059000010 dimerization interface [polypeptide binding]; other site 93059000011 ATP binding site [chemical binding]; other site 93059000012 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 93059000013 dimerization interface [polypeptide binding]; other site 93059000014 ATP binding site [chemical binding]; other site 93059000015 amidophosphoribosyltransferase; Provisional; Region: PRK09246 93059000016 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 93059000017 active site 93059000018 tetramer interface [polypeptide binding]; other site 93059000019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059000020 active site 93059000021 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 93059000022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93059000023 CAP-like domain; other site 93059000024 active site 93059000025 primary dimer interface [polypeptide binding]; other site 93059000026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059000027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059000028 TPR motif; other site 93059000029 binding surface 93059000030 TPR repeat; Region: TPR_11; pfam13414 93059000031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059000032 binding surface 93059000033 TPR motif; other site 93059000034 TPR repeat; Region: TPR_11; pfam13414 93059000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 93059000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 93059000037 Uncharacterized conserved protein [Function unknown]; Region: COG2928 93059000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 93059000039 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 93059000040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 93059000041 P loop; other site 93059000042 GTP binding site [chemical binding]; other site 93059000043 GAF domain; Region: GAF_3; pfam13492 93059000044 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 93059000045 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 93059000046 argininosuccinate lyase; Provisional; Region: PRK00855 93059000047 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 93059000048 active sites [active] 93059000049 tetramer interface [polypeptide binding]; other site 93059000050 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 93059000051 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93059000052 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 93059000053 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 93059000054 FMN binding site [chemical binding]; other site 93059000055 active site 93059000056 catalytic residues [active] 93059000057 substrate binding site [chemical binding]; other site 93059000058 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 93059000059 SelR domain; Region: SelR; pfam01641 93059000060 GrpE; Region: GrpE; pfam01025 93059000061 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 93059000062 dimer interface [polypeptide binding]; other site 93059000063 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 93059000064 chaperone protein DnaJ; Provisional; Region: PRK14293 93059000065 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93059000066 HSP70 interaction site [polypeptide binding]; other site 93059000067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 93059000068 substrate binding site [polypeptide binding]; other site 93059000069 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 93059000070 Zn binding sites [ion binding]; other site 93059000071 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93059000072 dimer interface [polypeptide binding]; other site 93059000073 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 93059000074 CPxP motif; other site 93059000075 Predicted GTPases [General function prediction only]; Region: COG1162 93059000076 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 93059000077 GTPase/Zn-binding domain interface [polypeptide binding]; other site 93059000078 GTP/Mg2+ binding site [chemical binding]; other site 93059000079 G4 box; other site 93059000080 G5 box; other site 93059000081 G1 box; other site 93059000082 Switch I region; other site 93059000083 G2 box; other site 93059000084 G3 box; other site 93059000085 Switch II region; other site 93059000086 hypothetical protein; Validated; Region: PRK00153 93059000087 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 93059000088 FAD binding domain; Region: FAD_binding_4; pfam01565 93059000089 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 93059000090 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 93059000091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93059000092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93059000093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93059000094 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 93059000095 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 93059000096 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 93059000097 thiamine monophosphate kinase; Provisional; Region: PRK05731 93059000098 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 93059000099 ATP binding site [chemical binding]; other site 93059000100 dimerization interface [polypeptide binding]; other site 93059000101 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 93059000102 active site 93059000103 elongation factor P; Validated; Region: PRK00529 93059000104 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 93059000105 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 93059000106 RNA binding site [nucleotide binding]; other site 93059000107 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 93059000108 RNA binding site [nucleotide binding]; other site 93059000109 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 93059000110 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 93059000111 carboxyltransferase (CT) interaction site; other site 93059000112 biotinylation site [posttranslational modification]; other site 93059000113 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 93059000114 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 93059000115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93059000116 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 93059000117 putative NAD(P) binding site [chemical binding]; other site 93059000118 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 93059000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93059000120 active site 93059000121 short chain dehydrogenase; Provisional; Region: PRK07201 93059000122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 93059000123 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 93059000124 homodimer interface [polypeptide binding]; other site 93059000125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000126 catalytic residue [active] 93059000127 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 93059000128 GMP synthase; Reviewed; Region: guaA; PRK00074 93059000129 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 93059000130 AMP/PPi binding site [chemical binding]; other site 93059000131 candidate oxyanion hole; other site 93059000132 catalytic triad [active] 93059000133 potential glutamine specificity residues [chemical binding]; other site 93059000134 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 93059000135 ATP Binding subdomain [chemical binding]; other site 93059000136 Ligand Binding sites [chemical binding]; other site 93059000137 Dimerization subdomain; other site 93059000138 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 93059000139 active site 93059000140 catalytic residues [active] 93059000141 Int/Topo IB signature motif; other site 93059000142 DNA binding site [nucleotide binding] 93059000143 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 93059000144 CcmE; Region: CcmE; cl00994 93059000145 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 93059000146 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 93059000147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93059000148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 93059000149 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 93059000150 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 93059000151 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 93059000152 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 93059000153 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 93059000154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93059000155 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 93059000156 Uncharacterized conserved protein [Function unknown]; Region: COG4279 93059000157 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 93059000158 SNF2 Helicase protein; Region: DUF3670; pfam12419 93059000159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059000160 ATP binding site [chemical binding]; other site 93059000161 putative Mg++ binding site [ion binding]; other site 93059000162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059000163 nucleotide binding region [chemical binding]; other site 93059000164 ATP-binding site [chemical binding]; other site 93059000165 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 93059000166 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 93059000167 motif 1; other site 93059000168 active site 93059000169 motif 2; other site 93059000170 motif 3; other site 93059000171 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 93059000172 DHHA1 domain; Region: DHHA1; pfam02272 93059000173 arginine decarboxylase; Provisional; Region: PRK05354 93059000174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 93059000175 dimer interface [polypeptide binding]; other site 93059000176 active site 93059000177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93059000178 catalytic residues [active] 93059000179 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 93059000180 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 93059000181 active site 93059000182 multimer interface [polypeptide binding]; other site 93059000183 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 93059000184 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 93059000185 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 93059000186 GatB domain; Region: GatB_Yqey; smart00845 93059000187 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 93059000188 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 93059000189 CoA-binding site [chemical binding]; other site 93059000190 ATP-binding [chemical binding]; other site 93059000191 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 93059000192 heterotetramer interface [polypeptide binding]; other site 93059000193 active site pocket [active] 93059000194 cleavage site 93059000195 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93059000196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059000197 Walker A/P-loop; other site 93059000198 ATP binding site [chemical binding]; other site 93059000199 Q-loop/lid; other site 93059000200 ABC transporter signature motif; other site 93059000201 Walker B; other site 93059000202 D-loop; other site 93059000203 H-loop/switch region; other site 93059000204 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 93059000205 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 93059000206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93059000207 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 93059000208 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 93059000209 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 93059000210 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93059000211 Walker A/P-loop; other site 93059000212 ATP binding site [chemical binding]; other site 93059000213 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 93059000214 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93059000215 ABC transporter signature motif; other site 93059000216 Walker B; other site 93059000217 D-loop; other site 93059000218 H-loop/switch region; other site 93059000219 PRC-barrel domain; Region: PRC; pfam05239 93059000220 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 93059000221 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 93059000222 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93059000223 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93059000224 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 93059000225 YGGT family; Region: YGGT; pfam02325 93059000226 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 93059000227 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 93059000228 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 93059000229 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 93059000230 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 93059000231 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 93059000232 nucleotide binding site/active site [active] 93059000233 HIT family signature motif; other site 93059000234 catalytic residue [active] 93059000235 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 93059000236 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 93059000237 active site 93059000238 catalytic residues [active] 93059000239 metal binding site [ion binding]; metal-binding site 93059000240 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 93059000241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 93059000242 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 93059000243 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 93059000244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059000245 catalytic residue [active] 93059000246 FeS assembly protein SufD; Region: sufD; TIGR01981 93059000247 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 93059000248 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 93059000249 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 93059000250 Walker A/P-loop; other site 93059000251 ATP binding site [chemical binding]; other site 93059000252 Q-loop/lid; other site 93059000253 ABC transporter signature motif; other site 93059000254 Walker B; other site 93059000255 D-loop; other site 93059000256 H-loop/switch region; other site 93059000257 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 93059000258 putative ABC transporter; Region: ycf24; CHL00085 93059000259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 93059000260 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 93059000261 phosphoglucomutase; Region: PLN02307 93059000262 active site 93059000263 substrate binding site [chemical binding]; other site 93059000264 metal binding site [ion binding]; metal-binding site 93059000265 recombination factor protein RarA; Reviewed; Region: PRK13342 93059000266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059000267 Walker A motif; other site 93059000268 ATP binding site [chemical binding]; other site 93059000269 Walker B motif; other site 93059000270 arginine finger; other site 93059000271 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 93059000272 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 93059000273 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93059000274 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 93059000275 catalytic triad [active] 93059000276 Type III pantothenate kinase; Region: Pan_kinase; cl17198 93059000277 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 93059000278 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 93059000279 Active Sites [active] 93059000280 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 93059000281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93059000282 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059000283 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93059000284 transmembrane helices; other site 93059000285 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93059000286 TrkA-C domain; Region: TrkA_C; pfam02080 93059000287 TrkA-C domain; Region: TrkA_C; pfam02080 93059000288 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93059000289 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 93059000290 Cation transport protein; Region: TrkH; cl17365 93059000291 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93059000292 TrkA-N domain; Region: TrkA_N; pfam02254 93059000293 TrkA-C domain; Region: TrkA_C; pfam02080 93059000294 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 93059000295 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 93059000296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 93059000297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059000298 Walker A/P-loop; other site 93059000299 ATP binding site [chemical binding]; other site 93059000300 Q-loop/lid; other site 93059000301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93059000302 ABC transporter; Region: ABC_tran_2; pfam12848 93059000303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93059000304 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 93059000305 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93059000306 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93059000307 protein binding site [polypeptide binding]; other site 93059000308 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 93059000309 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 93059000310 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 93059000311 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 93059000312 generic binding surface II; other site 93059000313 generic binding surface I; other site 93059000314 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 93059000315 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 93059000316 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 93059000317 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 93059000318 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 93059000319 active site 93059000320 Outer membrane efflux protein; Region: OEP; pfam02321 93059000321 Outer membrane efflux protein; Region: OEP; pfam02321 93059000322 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 93059000323 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 93059000324 Protein of unknown function (DUF512); Region: DUF512; pfam04459 93059000325 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 93059000326 L-aspartate oxidase; Provisional; Region: PRK07395 93059000327 L-aspartate oxidase; Provisional; Region: PRK06175 93059000328 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 93059000329 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 93059000330 substrate binding site [chemical binding]; other site 93059000331 putative active site [active] 93059000332 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93059000333 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 93059000334 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93059000335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059000336 FeS/SAM binding site; other site 93059000337 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 93059000338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 93059000339 Protein of unknown function, DUF482; Region: DUF482; pfam04339 93059000340 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 93059000341 RibD C-terminal domain; Region: RibD_C; cl17279 93059000342 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93059000343 active site 93059000344 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93059000345 active site 93059000346 shikimate kinase; Reviewed; Region: aroK; PRK00131 93059000347 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 93059000348 ADP binding site [chemical binding]; other site 93059000349 magnesium binding site [ion binding]; other site 93059000350 putative shikimate binding site; other site 93059000351 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 93059000352 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93059000353 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 93059000354 C-terminal domain interface [polypeptide binding]; other site 93059000355 GSH binding site (G-site) [chemical binding]; other site 93059000356 dimer interface [polypeptide binding]; other site 93059000357 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 93059000358 N-terminal domain interface [polypeptide binding]; other site 93059000359 Protein of unknown function (DUF751); Region: DUF751; pfam05421 93059000360 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 93059000361 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 93059000362 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 93059000363 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 93059000364 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 93059000365 active site 93059000366 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 93059000367 putative hydrophobic ligand binding site [chemical binding]; other site 93059000368 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 93059000369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93059000370 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 93059000371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059000372 binding surface 93059000373 TPR motif; other site 93059000374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 93059000375 conserved hypothetical protein; Region: TIGR03492 93059000376 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 93059000377 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 93059000378 putative NAD(P) binding site [chemical binding]; other site 93059000379 putative active site [active] 93059000380 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 93059000381 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93059000382 HSP70 interaction site [polypeptide binding]; other site 93059000383 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 93059000384 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93059000385 dimer interface [polypeptide binding]; other site 93059000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000387 catalytic residue [active] 93059000388 hypothetical protein; Provisional; Region: PRK13683 93059000389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93059000390 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93059000391 Walker A/P-loop; other site 93059000392 ATP binding site [chemical binding]; other site 93059000393 Q-loop/lid; other site 93059000394 ABC transporter signature motif; other site 93059000395 Walker B; other site 93059000396 D-loop; other site 93059000397 H-loop/switch region; other site 93059000398 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 93059000399 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 93059000400 putative trimer interface [polypeptide binding]; other site 93059000401 putative CoA binding site [chemical binding]; other site 93059000402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93059000403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93059000404 active site 93059000405 phosphorylation site [posttranslational modification] 93059000406 intermolecular recognition site; other site 93059000407 dimerization interface [polypeptide binding]; other site 93059000408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93059000409 DNA binding site [nucleotide binding] 93059000410 DNA polymerase III subunit delta'; Validated; Region: PRK07399 93059000411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93059000412 thymidylate kinase; Validated; Region: tmk; PRK00698 93059000413 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 93059000414 TMP-binding site; other site 93059000415 ATP-binding site [chemical binding]; other site 93059000416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 93059000417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93059000418 metal-binding site [ion binding] 93059000419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 93059000420 Soluble P-type ATPase [General function prediction only]; Region: COG4087 93059000421 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 93059000422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059000423 binding surface 93059000424 TPR motif; other site 93059000425 DNA repair protein RadA; Provisional; Region: PRK11823 93059000426 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93059000427 Walker A motif; other site 93059000428 ATP binding site [chemical binding]; other site 93059000429 Walker B motif; other site 93059000430 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 93059000431 Ycf27; Reviewed; Region: orf27; CHL00148 93059000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93059000433 active site 93059000434 phosphorylation site [posttranslational modification] 93059000435 intermolecular recognition site; other site 93059000436 dimerization interface [polypeptide binding]; other site 93059000437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93059000438 DNA binding site [nucleotide binding] 93059000439 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 93059000440 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 93059000441 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 93059000442 dimer interface [polypeptide binding]; other site 93059000443 active site 93059000444 CoA binding pocket [chemical binding]; other site 93059000445 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 93059000446 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 93059000447 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 93059000448 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 93059000449 putative acyl-acceptor binding pocket; other site 93059000450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 93059000451 putative active site [active] 93059000452 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 93059000453 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 93059000454 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 93059000455 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 93059000456 active site 93059000457 NTP binding site [chemical binding]; other site 93059000458 metal binding triad [ion binding]; metal-binding site 93059000459 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 93059000460 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93059000461 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 93059000462 active site lid residues [active] 93059000463 substrate binding pocket [chemical binding]; other site 93059000464 catalytic residues [active] 93059000465 substrate-Mg2+ binding site; other site 93059000466 aspartate-rich region 1; other site 93059000467 aspartate-rich region 2; other site 93059000468 phytoene desaturase; Region: phytoene_desat; TIGR02731 93059000469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93059000470 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 93059000471 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 93059000472 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 93059000473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93059000474 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 93059000475 putative dimerization interface [polypeptide binding]; other site 93059000476 NnrU protein; Region: NnrU; cl17713 93059000477 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 93059000478 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 93059000479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93059000480 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 93059000481 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 93059000482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93059000483 ScpA/B protein; Region: ScpA_ScpB; cl00598 93059000484 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93059000485 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 93059000486 active site 93059000487 Substrate binding site; other site 93059000488 Mg++ binding site; other site 93059000489 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 93059000490 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 93059000491 FAD binding site [chemical binding]; other site 93059000492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93059000493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93059000494 DNA binding residues [nucleotide binding] 93059000495 dimerization interface [polypeptide binding]; other site 93059000496 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 93059000497 putative active site [active] 93059000498 putative metal binding residues [ion binding]; other site 93059000499 signature motif; other site 93059000500 putative dimer interface [polypeptide binding]; other site 93059000501 putative phosphate binding site [ion binding]; other site 93059000502 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 93059000503 ATP-NAD kinase; Region: NAD_kinase; pfam01513 93059000504 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 93059000505 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 93059000506 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 93059000507 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 93059000508 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 93059000509 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 93059000510 NADH dehydrogenase; Region: NADHdh; cl00469 93059000511 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 93059000512 citrate synthase; Provisional; Region: PRK14036 93059000513 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 93059000514 oxalacetate binding site [chemical binding]; other site 93059000515 citrylCoA binding site [chemical binding]; other site 93059000516 coenzyme A binding site [chemical binding]; other site 93059000517 catalytic triad [active] 93059000518 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 93059000519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 93059000520 active site residue [active] 93059000521 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 93059000522 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 93059000523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000524 catalytic residue [active] 93059000525 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 93059000526 putative rRNA binding site [nucleotide binding]; other site 93059000527 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 93059000528 ligand-binding site [chemical binding]; other site 93059000529 AIR carboxylase; Region: AIRC; pfam00731 93059000530 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 93059000531 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 93059000532 active site 93059000533 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 93059000534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93059000535 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 93059000536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93059000537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93059000538 active site 93059000539 phosphorylation site [posttranslational modification] 93059000540 intermolecular recognition site; other site 93059000541 dimerization interface [polypeptide binding]; other site 93059000542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93059000543 DNA binding residues [nucleotide binding] 93059000544 dimerization interface [polypeptide binding]; other site 93059000545 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 93059000546 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 93059000547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059000548 catalytic residue [active] 93059000549 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 93059000550 MraW methylase family; Region: Methyltransf_5; cl17771 93059000551 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 93059000552 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 93059000553 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93059000554 active site 93059000555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93059000556 acyl-activating enzyme (AAE) consensus motif; other site 93059000557 AMP binding site [chemical binding]; other site 93059000558 active site 93059000559 CoA binding site [chemical binding]; other site 93059000560 O-succinylbenzoate synthase; Provisional; Region: PRK02714 93059000561 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 93059000562 active site 93059000563 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 93059000564 UbiA prenyltransferase family; Region: UbiA; pfam01040 93059000565 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 93059000566 chorismate binding enzyme; Region: Chorismate_bind; cl10555 93059000567 glutathione synthetase; Provisional; Region: PRK05246 93059000568 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 93059000569 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 93059000570 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 93059000571 GSH binding site [chemical binding]; other site 93059000572 catalytic residues [active] 93059000573 peptide chain release factor 2; Validated; Region: prfB; PRK00578 93059000574 PCRF domain; Region: PCRF; pfam03462 93059000575 RF-1 domain; Region: RF-1; pfam00472 93059000576 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 93059000577 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 93059000578 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 93059000579 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 93059000580 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 93059000581 glutamine binding [chemical binding]; other site 93059000582 catalytic triad [active] 93059000583 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 93059000584 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 93059000585 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 93059000586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93059000587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000588 homodimer interface [polypeptide binding]; other site 93059000589 catalytic residue [active] 93059000590 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 93059000591 arginine-tRNA ligase; Region: PLN02286 93059000592 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 93059000593 active site 93059000594 HIGH motif; other site 93059000595 KMSK motif region; other site 93059000596 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 93059000597 tRNA binding surface [nucleotide binding]; other site 93059000598 anticodon binding site; other site 93059000599 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 93059000600 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 93059000601 dimerization interface [polypeptide binding]; other site 93059000602 active site 93059000603 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 93059000604 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 93059000605 trmE is a tRNA modification GTPase; Region: trmE; cd04164 93059000606 G1 box; other site 93059000607 GTP/Mg2+ binding site [chemical binding]; other site 93059000608 Switch I region; other site 93059000609 G2 box; other site 93059000610 Switch II region; other site 93059000611 G3 box; other site 93059000612 G4 box; other site 93059000613 G5 box; other site 93059000614 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 93059000615 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 93059000616 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 93059000617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93059000618 Zn2+ binding site [ion binding]; other site 93059000619 Mg2+ binding site [ion binding]; other site 93059000620 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 93059000621 synthetase active site [active] 93059000622 NTP binding site [chemical binding]; other site 93059000623 metal binding site [ion binding]; metal-binding site 93059000624 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 93059000625 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 93059000626 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 93059000627 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93059000628 Walker A/P-loop; other site 93059000629 ATP binding site [chemical binding]; other site 93059000630 Q-loop/lid; other site 93059000631 ABC transporter signature motif; other site 93059000632 Walker B; other site 93059000633 D-loop; other site 93059000634 H-loop/switch region; other site 93059000635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93059000636 Walker A/P-loop; other site 93059000637 ATP binding site [chemical binding]; other site 93059000638 Q-loop/lid; other site 93059000639 ABC transporter signature motif; other site 93059000640 Walker B; other site 93059000641 D-loop; other site 93059000642 H-loop/switch region; other site 93059000643 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 93059000644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059000645 RNA binding surface [nucleotide binding]; other site 93059000646 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 93059000647 active site 93059000648 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 93059000649 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 93059000650 GTP/Mg2+ binding site [chemical binding]; other site 93059000651 G4 box; other site 93059000652 G5 box; other site 93059000653 G1 box; other site 93059000654 Switch I region; other site 93059000655 G2 box; other site 93059000656 G3 box; other site 93059000657 Switch II region; other site 93059000658 Phosphoglycerate kinase; Region: PGK; pfam00162 93059000659 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 93059000660 substrate binding site [chemical binding]; other site 93059000661 hinge regions; other site 93059000662 ADP binding site [chemical binding]; other site 93059000663 catalytic site [active] 93059000664 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 93059000665 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 93059000666 active site 93059000667 homodimer interface [polypeptide binding]; other site 93059000668 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 93059000669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93059000670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000671 homodimer interface [polypeptide binding]; other site 93059000672 catalytic residue [active] 93059000673 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 93059000674 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 93059000675 quinone interaction residues [chemical binding]; other site 93059000676 active site 93059000677 catalytic residues [active] 93059000678 FMN binding site [chemical binding]; other site 93059000679 substrate binding site [chemical binding]; other site 93059000680 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 93059000681 RNA/DNA hybrid binding site [nucleotide binding]; other site 93059000682 active site 93059000683 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 93059000684 L11 interface [polypeptide binding]; other site 93059000685 putative EF-Tu interaction site [polypeptide binding]; other site 93059000686 putative EF-G interaction site [polypeptide binding]; other site 93059000687 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 93059000688 23S rRNA interface [nucleotide binding]; other site 93059000689 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 93059000690 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 93059000691 mRNA/rRNA interface [nucleotide binding]; other site 93059000692 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 93059000693 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 93059000694 23S rRNA interface [nucleotide binding]; other site 93059000695 L7/L12 interface [polypeptide binding]; other site 93059000696 putative thiostrepton binding site; other site 93059000697 L25 interface [polypeptide binding]; other site 93059000698 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 93059000699 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 93059000700 putative homodimer interface [polypeptide binding]; other site 93059000701 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 93059000702 heterodimer interface [polypeptide binding]; other site 93059000703 homodimer interface [polypeptide binding]; other site 93059000704 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 93059000705 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 93059000706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059000707 Walker A motif; other site 93059000708 ATP binding site [chemical binding]; other site 93059000709 Walker B motif; other site 93059000710 arginine finger; other site 93059000711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059000712 Walker A motif; other site 93059000713 ATP binding site [chemical binding]; other site 93059000714 Walker B motif; other site 93059000715 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93059000716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 93059000717 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 93059000718 dimer interface [polypeptide binding]; other site 93059000719 active site 93059000720 metal binding site [ion binding]; metal-binding site 93059000721 glutathione binding site [chemical binding]; other site 93059000722 enolase; Provisional; Region: eno; PRK00077 93059000723 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 93059000724 dimer interface [polypeptide binding]; other site 93059000725 metal binding site [ion binding]; metal-binding site 93059000726 substrate binding pocket [chemical binding]; other site 93059000727 ABC1 family; Region: ABC1; cl17513 93059000728 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 93059000729 ABC1 family; Region: ABC1; cl17513 93059000730 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 93059000731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93059000732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059000733 Domain of unknown function (DUF897); Region: DUF897; pfam05982 93059000734 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 93059000735 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 93059000736 Sulfate transporter family; Region: Sulfate_transp; pfam00916 93059000737 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 93059000738 chaperone protein DnaJ; Provisional; Region: PRK14299 93059000739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93059000740 HSP70 interaction site [polypeptide binding]; other site 93059000741 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93059000742 substrate binding site [polypeptide binding]; other site 93059000743 dimer interface [polypeptide binding]; other site 93059000744 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 93059000745 dimer interface [polypeptide binding]; other site 93059000746 active site 93059000747 aspartate-rich active site metal binding site; other site 93059000748 allosteric magnesium binding site [ion binding]; other site 93059000749 Schiff base residues; other site 93059000750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 93059000751 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 93059000752 active site 93059000753 metal binding site [ion binding]; metal-binding site 93059000754 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 93059000755 MutS domain III; Region: MutS_III; pfam05192 93059000756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059000757 Walker A/P-loop; other site 93059000758 ATP binding site [chemical binding]; other site 93059000759 Q-loop/lid; other site 93059000760 ABC transporter signature motif; other site 93059000761 Walker B; other site 93059000762 D-loop; other site 93059000763 H-loop/switch region; other site 93059000764 Smr domain; Region: Smr; pfam01713 93059000765 GTPase CgtA; Reviewed; Region: obgE; PRK12299 93059000766 GTP1/OBG; Region: GTP1_OBG; pfam01018 93059000767 Obg GTPase; Region: Obg; cd01898 93059000768 G1 box; other site 93059000769 GTP/Mg2+ binding site [chemical binding]; other site 93059000770 Switch I region; other site 93059000771 G2 box; other site 93059000772 G3 box; other site 93059000773 Switch II region; other site 93059000774 G4 box; other site 93059000775 G5 box; other site 93059000776 CP12 domain; Region: CP12; pfam02672 93059000777 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 93059000778 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 93059000779 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 93059000780 putative dimer interface [polypeptide binding]; other site 93059000781 N-terminal domain interface [polypeptide binding]; other site 93059000782 putative substrate binding pocket (H-site) [chemical binding]; other site 93059000783 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 93059000784 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 93059000785 active site 93059000786 Zn binding site [ion binding]; other site 93059000787 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 93059000788 protein I interface; other site 93059000789 D2 interface; other site 93059000790 protein T interface; other site 93059000791 chlorophyll binding site; other site 93059000792 beta carotene binding site; other site 93059000793 pheophytin binding site; other site 93059000794 manganese-stabilizing polypeptide interface; other site 93059000795 CP43 interface; other site 93059000796 protein L interface; other site 93059000797 oxygen evolving complex binding site; other site 93059000798 bromide binding site; other site 93059000799 quinone binding site; other site 93059000800 Fe binding site [ion binding]; other site 93059000801 core light harvesting interface; other site 93059000802 cytochrome b559 alpha subunit interface; other site 93059000803 cytochrome c-550 interface; other site 93059000804 protein J interface; other site 93059000805 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 93059000806 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 93059000807 Tetramer interface [polypeptide binding]; other site 93059000808 active site 93059000809 FMN-binding site [chemical binding]; other site 93059000810 FtsH Extracellular; Region: FtsH_ext; pfam06480 93059000811 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 93059000812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059000813 Walker A motif; other site 93059000814 ATP binding site [chemical binding]; other site 93059000815 Walker B motif; other site 93059000816 arginine finger; other site 93059000817 Peptidase family M41; Region: Peptidase_M41; pfam01434 93059000818 ATP sulphurylase; Region: sopT; TIGR00339 93059000819 ATP-sulfurylase; Region: ATPS; cd00517 93059000820 active site 93059000821 HXXH motif; other site 93059000822 flexible loop; other site 93059000823 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 93059000824 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 93059000825 Flavoprotein; Region: Flavoprotein; pfam02441 93059000826 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 93059000827 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 93059000828 Protein of unknown function (DUF565); Region: DUF565; pfam04483 93059000829 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 93059000830 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93059000831 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93059000832 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 93059000833 active site 93059000834 DNA binding site [nucleotide binding] 93059000835 Creatinine amidohydrolase; Region: Creatininase; pfam02633 93059000836 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 93059000837 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 93059000838 Fatty acid desaturase; Region: FA_desaturase; pfam00487 93059000839 putative di-iron ligands [ion binding]; other site 93059000840 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 93059000841 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93059000842 active site 93059000843 HIGH motif; other site 93059000844 nucleotide binding site [chemical binding]; other site 93059000845 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 93059000846 active site 93059000847 KMSKS motif; other site 93059000848 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 93059000849 tRNA binding surface [nucleotide binding]; other site 93059000850 anticodon binding site; other site 93059000851 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 93059000852 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 93059000853 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 93059000854 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 93059000855 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 93059000856 active site 93059000857 substrate binding site [chemical binding]; other site 93059000858 metal binding site [ion binding]; metal-binding site 93059000859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93059000860 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 93059000861 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 93059000862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 93059000863 trimer interface [polypeptide binding]; other site 93059000864 active site 93059000865 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 93059000866 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 93059000867 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 93059000868 ligand binding site [chemical binding]; other site 93059000869 flexible hinge region; other site 93059000870 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 93059000871 putative switch regulator; other site 93059000872 non-specific DNA interactions [nucleotide binding]; other site 93059000873 DNA binding site [nucleotide binding] 93059000874 putative cAMP binding site [chemical binding]; other site 93059000875 sequence specific DNA binding site [nucleotide binding]; other site 93059000876 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 93059000877 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 93059000878 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 93059000879 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 93059000880 putative active site [active] 93059000881 catalytic residue [active] 93059000882 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 93059000883 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 93059000884 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 93059000885 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 93059000886 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 93059000887 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 93059000888 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 93059000889 substrate binding site [chemical binding]; other site 93059000890 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 93059000891 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 93059000892 substrate binding site [chemical binding]; other site 93059000893 ligand binding site [chemical binding]; other site 93059000894 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 93059000895 competence damage-inducible protein A; Provisional; Region: PRK00549 93059000896 putative MPT binding site; other site 93059000897 Competence-damaged protein; Region: CinA; pfam02464 93059000898 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 93059000899 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 93059000900 dimer interface [polypeptide binding]; other site 93059000901 active site 93059000902 glycine-pyridoxal phosphate binding site [chemical binding]; other site 93059000903 folate binding site [chemical binding]; other site 93059000904 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 93059000905 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 93059000906 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 93059000907 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 93059000908 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 93059000909 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 93059000910 DoxX; Region: DoxX; pfam07681 93059000911 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 93059000912 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 93059000913 purine monophosphate binding site [chemical binding]; other site 93059000914 dimer interface [polypeptide binding]; other site 93059000915 putative catalytic residues [active] 93059000916 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 93059000917 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 93059000918 putative hydrolase; Provisional; Region: PRK11460 93059000919 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 93059000920 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 93059000921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93059000922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93059000923 dimer interface [polypeptide binding]; other site 93059000924 phosphorylation site [posttranslational modification] 93059000925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059000926 Mg2+ binding site [ion binding]; other site 93059000927 G-X-G motif; other site 93059000928 cobalamin synthase; Reviewed; Region: cobS; PRK00235 93059000929 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 93059000930 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 93059000931 photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553 93059000932 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93059000933 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93059000934 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 93059000935 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 93059000936 Domain of unknown function DUF21; Region: DUF21; pfam01595 93059000937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93059000938 Transporter associated domain; Region: CorC_HlyC; smart01091 93059000939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059000940 active site 93059000941 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 93059000942 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 93059000943 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 93059000944 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 93059000945 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 93059000946 Y-family of DNA polymerases; Region: PolY; cl12025 93059000947 RNase_H superfamily; Region: RNase_H_2; pfam13482 93059000948 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 93059000949 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 93059000950 active site 93059000951 substrate binding site [chemical binding]; other site 93059000952 metal binding site [ion binding]; metal-binding site 93059000953 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 93059000954 active site 93059000955 dimerization interface [polypeptide binding]; other site 93059000956 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 93059000957 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 93059000958 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 93059000959 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 93059000960 putative active site pocket [active] 93059000961 4-fold oligomerization interface [polypeptide binding]; other site 93059000962 metal binding residues [ion binding]; metal-binding site 93059000963 3-fold/trimer interface [polypeptide binding]; other site 93059000964 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 93059000965 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 93059000966 NAD binding site [chemical binding]; other site 93059000967 homotetramer interface [polypeptide binding]; other site 93059000968 homodimer interface [polypeptide binding]; other site 93059000969 substrate binding site [chemical binding]; other site 93059000970 active site 93059000971 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 93059000972 putative catalytic residue [active] 93059000973 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 93059000974 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 93059000975 inhibitor-cofactor binding pocket; inhibition site 93059000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059000977 catalytic residue [active] 93059000978 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 93059000979 dimer interface [polypeptide binding]; other site 93059000980 ADP-ribose binding site [chemical binding]; other site 93059000981 active site 93059000982 nudix motif; other site 93059000983 metal binding site [ion binding]; metal-binding site 93059000984 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 93059000985 catalytic center binding site [active] 93059000986 ATP binding site [chemical binding]; other site 93059000987 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 93059000988 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 93059000989 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 93059000990 metal ion-dependent adhesion site (MIDAS); other site 93059000991 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 93059000992 mce related protein; Region: MCE; pfam02470 93059000993 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 93059000994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059000995 Walker A/P-loop; other site 93059000996 ATP binding site [chemical binding]; other site 93059000997 Q-loop/lid; other site 93059000998 ABC transporter signature motif; other site 93059000999 Walker B; other site 93059001000 D-loop; other site 93059001001 H-loop/switch region; other site 93059001002 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 93059001003 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 93059001004 phosphate binding site [ion binding]; other site 93059001005 putative substrate binding pocket [chemical binding]; other site 93059001006 dimer interface [polypeptide binding]; other site 93059001007 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 93059001008 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 93059001009 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 93059001010 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 93059001011 Rubredoxin [Energy production and conversion]; Region: COG1773 93059001012 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 93059001013 iron binding site [ion binding]; other site 93059001014 Ycf48-like protein; Provisional; Region: PRK13684 93059001015 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 93059001016 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 93059001017 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 93059001018 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 93059001019 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 93059001020 photosystem II reaction center protein J; Provisional; Region: PRK02565 93059001021 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 93059001022 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 93059001023 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 93059001024 dimerization interface [polypeptide binding]; other site 93059001025 putative ATP binding site [chemical binding]; other site 93059001026 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 93059001027 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 93059001028 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 93059001029 active site 93059001030 NTP binding site [chemical binding]; other site 93059001031 metal binding triad [ion binding]; metal-binding site 93059001032 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 93059001033 Part of AAA domain; Region: AAA_19; pfam13245 93059001034 Family description; Region: UvrD_C_2; pfam13538 93059001035 Phycobilisome protein; Region: Phycobilisome; cl08227 93059001036 Phycobilisome protein; Region: Phycobilisome; cl08227 93059001037 HEAT repeats; Region: HEAT_2; pfam13646 93059001038 HEAT repeats; Region: HEAT_2; pfam13646 93059001039 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 93059001040 HEAT repeats; Region: HEAT_2; pfam13646 93059001041 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 93059001042 CpeS-like protein; Region: CpeS; pfam09367 93059001043 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 93059001044 PUCC protein; Region: PUCC; pfam03209 93059001045 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 93059001046 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 93059001047 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 93059001048 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 93059001049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93059001050 nucleotide binding site [chemical binding]; other site 93059001051 S-adenosylmethionine synthetase; Validated; Region: PRK05250 93059001052 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 93059001053 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 93059001054 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 93059001055 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93059001056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 93059001057 motif I; other site 93059001058 active site 93059001059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93059001060 motif II; other site 93059001061 30S ribosomal protein S1; Reviewed; Region: PRK07400 93059001062 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 93059001063 RNA binding site [nucleotide binding]; other site 93059001064 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 93059001065 RNA binding site [nucleotide binding]; other site 93059001066 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 93059001067 RNA binding site [nucleotide binding]; other site 93059001068 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 93059001069 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 93059001070 ATP cone domain; Region: ATP-cone; pfam03477 93059001071 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 93059001072 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93059001073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93059001074 catalytic loop [active] 93059001075 iron binding site [ion binding]; other site 93059001076 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93059001077 active site 93059001078 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 93059001079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059001080 S-adenosylmethionine binding site [chemical binding]; other site 93059001081 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 93059001082 cell division topological specificity factor MinE; Provisional; Region: PRK13988 93059001083 septum site-determining protein MinD; Region: minD_bact; TIGR01968 93059001084 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 93059001085 P-loop; other site 93059001086 ADP binding residues [chemical binding]; other site 93059001087 Switch I; other site 93059001088 Switch II; other site 93059001089 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 93059001090 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 93059001091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93059001092 Zn2+ binding site [ion binding]; other site 93059001093 Mg2+ binding site [ion binding]; other site 93059001094 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 93059001095 C-terminal peptidase (prc); Region: prc; TIGR00225 93059001096 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93059001097 protein binding site [polypeptide binding]; other site 93059001098 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 93059001099 Catalytic dyad [active] 93059001100 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 93059001101 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 93059001102 Qi binding site; other site 93059001103 intrachain domain interface; other site 93059001104 interchain domain interface [polypeptide binding]; other site 93059001105 heme bH binding site [chemical binding]; other site 93059001106 heme bL binding site [chemical binding]; other site 93059001107 Qo binding site; other site 93059001108 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 93059001109 interchain domain interface [polypeptide binding]; other site 93059001110 intrachain domain interface; other site 93059001111 Qi binding site; other site 93059001112 Qo binding site; other site 93059001113 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 93059001114 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 93059001115 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 93059001116 DNA binding site [nucleotide binding] 93059001117 catalytic residue [active] 93059001118 H2TH interface [polypeptide binding]; other site 93059001119 putative catalytic residues [active] 93059001120 turnover-facilitating residue; other site 93059001121 intercalation triad [nucleotide binding]; other site 93059001122 8OG recognition residue [nucleotide binding]; other site 93059001123 putative reading head residues; other site 93059001124 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 93059001125 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 93059001126 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 93059001127 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93059001128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93059001129 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93059001130 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 93059001131 NAD(P) binding site [chemical binding]; other site 93059001132 catalytic residues [active] 93059001133 Uncharacterized conserved protein [Function unknown]; Region: COG0398 93059001134 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93059001135 NADH dehydrogenase subunit G; Validated; Region: PRK08493 93059001136 GLTT repeat (6 copies); Region: GLTT; pfam01744 93059001137 GLTT repeat (6 copies); Region: GLTT; pfam01744 93059001138 Protein of unknown function; Region: DUF3721; pfam12518 93059001139 HupE / UreJ protein; Region: HupE_UreJ; cl01011 93059001140 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 93059001141 integrase; Provisional; Region: int; PHA02601 93059001142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93059001143 active site 93059001144 DNA binding site [nucleotide binding] 93059001145 Int/Topo IB signature motif; other site 93059001146 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 93059001147 Dehydroquinase class II; Region: DHquinase_II; pfam01220 93059001148 active site 93059001149 trimer interface [polypeptide binding]; other site 93059001150 dimer interface [polypeptide binding]; other site 93059001151 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 93059001152 active site 93059001153 dinuclear metal binding site [ion binding]; other site 93059001154 dimerization interface [polypeptide binding]; other site 93059001155 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 93059001156 active site 93059001157 SAM binding site [chemical binding]; other site 93059001158 homodimer interface [polypeptide binding]; other site 93059001159 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 93059001160 GTP-binding protein Der; Reviewed; Region: PRK00093 93059001161 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 93059001162 G1 box; other site 93059001163 GTP/Mg2+ binding site [chemical binding]; other site 93059001164 Switch I region; other site 93059001165 G2 box; other site 93059001166 Switch II region; other site 93059001167 G3 box; other site 93059001168 G4 box; other site 93059001169 G5 box; other site 93059001170 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 93059001171 G1 box; other site 93059001172 GTP/Mg2+ binding site [chemical binding]; other site 93059001173 Switch I region; other site 93059001174 G2 box; other site 93059001175 G3 box; other site 93059001176 Switch II region; other site 93059001177 G4 box; other site 93059001178 G5 box; other site 93059001179 Cobalt transport protein; Region: CbiQ; cl00463 93059001180 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 93059001181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 93059001182 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93059001183 catalytic residue [active] 93059001184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 93059001185 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 93059001186 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 93059001187 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 93059001188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93059001189 H+ Antiporter protein; Region: 2A0121; TIGR00900 93059001190 Recombination protein O N terminal; Region: RecO_N; pfam11967 93059001191 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 93059001192 Recombination protein O C terminal; Region: RecO_C; pfam02565 93059001193 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 93059001194 intersubunit interface [polypeptide binding]; other site 93059001195 active site 93059001196 catalytic residue [active] 93059001197 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 93059001198 30S subunit binding site; other site 93059001199 lipoate-protein ligase B; Provisional; Region: PRK14344 93059001200 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 93059001201 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 93059001202 acyl-activating enzyme (AAE) consensus motif; other site 93059001203 putative AMP binding site [chemical binding]; other site 93059001204 putative active site [active] 93059001205 putative CoA binding site [chemical binding]; other site 93059001206 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 93059001207 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 93059001208 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 93059001209 E3 interaction surface; other site 93059001210 lipoyl attachment site [posttranslational modification]; other site 93059001211 e3 binding domain; Region: E3_binding; pfam02817 93059001212 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 93059001213 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 93059001214 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 93059001215 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 93059001216 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93059001217 dimer interface [polypeptide binding]; other site 93059001218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059001219 catalytic residue [active] 93059001220 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 93059001221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93059001222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059001223 catalytic residue [active] 93059001224 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 93059001225 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93059001226 homodimer interface [polypeptide binding]; other site 93059001227 substrate-cofactor binding pocket; other site 93059001228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059001229 catalytic residue [active] 93059001230 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 93059001231 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 93059001232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059001233 RNA binding surface [nucleotide binding]; other site 93059001234 Haemolytic domain; Region: Haemolytic; pfam01809 93059001235 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 93059001236 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 93059001237 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93059001238 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93059001239 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93059001240 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 93059001241 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93059001242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059001243 catalytic residue [active] 93059001244 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93059001245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059001246 S-adenosylmethionine binding site [chemical binding]; other site 93059001247 NifU-like domain; Region: NifU; pfam01106 93059001248 malate:quinone oxidoreductase; Validated; Region: PRK05257 93059001249 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 93059001250 GTP-binding protein LepA; Provisional; Region: PRK05433 93059001251 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 93059001252 G1 box; other site 93059001253 putative GEF interaction site [polypeptide binding]; other site 93059001254 GTP/Mg2+ binding site [chemical binding]; other site 93059001255 Switch I region; other site 93059001256 G2 box; other site 93059001257 G3 box; other site 93059001258 Switch II region; other site 93059001259 G4 box; other site 93059001260 G5 box; other site 93059001261 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 93059001262 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 93059001263 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 93059001264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93059001265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059001266 dimer interface [polypeptide binding]; other site 93059001267 conserved gate region; other site 93059001268 ABC-ATPase subunit interface; other site 93059001269 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 93059001270 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93059001271 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 93059001272 16S rRNA methyltransferase B; Provisional; Region: PRK14901 93059001273 NusB family; Region: NusB; pfam01029 93059001274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059001275 S-adenosylmethionine binding site [chemical binding]; other site 93059001276 Transglycosylase; Region: Transgly; pfam00912 93059001277 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 93059001278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 93059001279 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 93059001280 UbiA prenyltransferase family; Region: UbiA; pfam01040 93059001281 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93059001282 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 93059001283 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 93059001284 substrate binding site [chemical binding]; other site 93059001285 glutamase interaction surface [polypeptide binding]; other site 93059001286 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 93059001287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059001288 S-adenosylmethionine binding site [chemical binding]; other site 93059001289 Protein of unknown function (DUF721); Region: DUF721; pfam05258 93059001290 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 93059001291 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 93059001292 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 93059001293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93059001294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93059001295 Walker A/P-loop; other site 93059001296 ATP binding site [chemical binding]; other site 93059001297 Q-loop/lid; other site 93059001298 ABC transporter signature motif; other site 93059001299 Walker B; other site 93059001300 D-loop; other site 93059001301 H-loop/switch region; other site 93059001302 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 93059001303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93059001304 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 93059001305 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 93059001306 active site 93059001307 interdomain interaction site; other site 93059001308 putative metal-binding site [ion binding]; other site 93059001309 nucleotide binding site [chemical binding]; other site 93059001310 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 93059001311 domain I; other site 93059001312 phosphate binding site [ion binding]; other site 93059001313 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 93059001314 domain II; other site 93059001315 domain III; other site 93059001316 nucleotide binding site [chemical binding]; other site 93059001317 DNA binding groove [nucleotide binding] 93059001318 catalytic site [active] 93059001319 domain IV; other site 93059001320 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93059001321 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93059001322 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93059001323 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 93059001324 hypothetical protein; Provisional; Region: PRK04447 93059001325 active site pocket [active] 93059001326 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 93059001327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93059001328 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 93059001329 active site 93059001330 catalytic tetrad [active] 93059001331 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 93059001332 Lumazine binding domain; Region: Lum_binding; pfam00677 93059001333 Lumazine binding domain; Region: Lum_binding; pfam00677 93059001334 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 93059001335 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 93059001336 Subunit I/III interface [polypeptide binding]; other site 93059001337 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 93059001338 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 93059001339 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 93059001340 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 93059001341 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 93059001342 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 93059001343 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 93059001344 UbiA prenyltransferase family; Region: UbiA; pfam01040 93059001345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059001346 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 93059001347 Walker A/P-loop; other site 93059001348 ATP binding site [chemical binding]; other site 93059001349 Q-loop/lid; other site 93059001350 ABC transporter signature motif; other site 93059001351 Walker B; other site 93059001352 D-loop; other site 93059001353 H-loop/switch region; other site 93059001354 ABC-2 type transporter; Region: ABC2_membrane; cl17235 93059001355 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 93059001356 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 93059001357 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 93059001358 ring oligomerisation interface [polypeptide binding]; other site 93059001359 ATP/Mg binding site [chemical binding]; other site 93059001360 stacking interactions; other site 93059001361 hinge regions; other site 93059001362 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 93059001363 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 93059001364 NAD(P) binding site [chemical binding]; other site 93059001365 homotetramer interface [polypeptide binding]; other site 93059001366 homodimer interface [polypeptide binding]; other site 93059001367 active site 93059001368 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 93059001369 substrate binding site; other site 93059001370 dimer interface; other site 93059001371 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 93059001372 dimer interface [polypeptide binding]; other site 93059001373 catalytic triad [active] 93059001374 prenyltransferase; Reviewed; Region: ubiA; PRK12873 93059001375 UbiA prenyltransferase family; Region: UbiA; pfam01040 93059001376 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 93059001377 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 93059001378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93059001379 non-specific DNA binding site [nucleotide binding]; other site 93059001380 salt bridge; other site 93059001381 sequence-specific DNA binding site [nucleotide binding]; other site 93059001382 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 93059001383 active site 93059001384 SAM binding site [chemical binding]; other site 93059001385 homodimer interface [polypeptide binding]; other site 93059001386 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 93059001387 apocytochrome f; Reviewed; Region: PRK02693 93059001388 cytochrome f; Region: petA; CHL00037 93059001389 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 93059001390 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 93059001391 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 93059001392 cytochrome b subunit interaction site [polypeptide binding]; other site 93059001393 [2Fe-2S] cluster binding site [ion binding]; other site 93059001394 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 93059001395 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 93059001396 Domain of unknown function (DUF814); Region: DUF814; pfam05670 93059001397 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 93059001398 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 93059001399 catalytic site [active] 93059001400 G-X2-G-X-G-K; other site 93059001401 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 93059001402 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 93059001403 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 93059001404 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 93059001405 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 93059001406 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 93059001407 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 93059001408 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 93059001409 HIGH motif; other site 93059001410 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 93059001411 active site 93059001412 KMSKS motif; other site 93059001413 Src Homology 3 domain superfamily; Region: SH3; cl17036 93059001414 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 93059001415 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 93059001416 active site 93059001417 short chain dehydrogenase; Provisional; Region: PRK12367 93059001418 NAD(P) binding site [chemical binding]; other site 93059001419 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 93059001420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93059001421 DRTGG domain; Region: DRTGG; pfam07085 93059001422 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 93059001423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 93059001424 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 93059001425 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 93059001426 SPFH domain / Band 7 family; Region: Band_7; pfam01145 93059001427 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 93059001428 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93059001429 inhibitor-cofactor binding pocket; inhibition site 93059001430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059001431 catalytic residue [active] 93059001432 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 93059001433 putative catalytic site [active] 93059001434 putative phosphate binding site [ion binding]; other site 93059001435 active site 93059001436 metal binding site A [ion binding]; metal-binding site 93059001437 DNA binding site [nucleotide binding] 93059001438 putative AP binding site [nucleotide binding]; other site 93059001439 putative metal binding site B [ion binding]; other site 93059001440 hypothetical protein; Provisional; Region: PRK04194 93059001441 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 93059001442 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 93059001443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059001444 dimer interface [polypeptide binding]; other site 93059001445 conserved gate region; other site 93059001446 putative PBP binding loops; other site 93059001447 ABC-ATPase subunit interface; other site 93059001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059001449 dimer interface [polypeptide binding]; other site 93059001450 conserved gate region; other site 93059001451 putative PBP binding loops; other site 93059001452 ABC-ATPase subunit interface; other site 93059001453 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 93059001454 aromatic arch; other site 93059001455 DCoH dimer interaction site [polypeptide binding]; other site 93059001456 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 93059001457 DCoH tetramer interaction site [polypeptide binding]; other site 93059001458 substrate binding site [chemical binding]; other site 93059001459 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 93059001460 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 93059001461 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 93059001462 active site 93059001463 Zn binding site [ion binding]; other site 93059001464 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 93059001465 dimer interface [polypeptide binding]; other site 93059001466 substrate binding site [chemical binding]; other site 93059001467 metal binding sites [ion binding]; metal-binding site 93059001468 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 93059001469 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 93059001470 domain interfaces; other site 93059001471 active site 93059001472 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 93059001473 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93059001474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93059001475 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93059001476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93059001477 DNA binding residues [nucleotide binding] 93059001478 primosome assembly protein PriA; Validated; Region: PRK05580 93059001479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059001480 ATP binding site [chemical binding]; other site 93059001481 putative Mg++ binding site [ion binding]; other site 93059001482 nucleotide binding region [chemical binding]; other site 93059001483 helicase superfamily c-terminal domain; Region: HELICc; smart00490 93059001484 ATP-binding site [chemical binding]; other site 93059001485 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 93059001486 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 93059001487 feedback inhibition sensing region; other site 93059001488 homohexameric interface [polypeptide binding]; other site 93059001489 nucleotide binding site [chemical binding]; other site 93059001490 N-acetyl-L-glutamate binding site [chemical binding]; other site 93059001491 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 93059001492 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93059001493 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93059001494 ssDNA binding site [nucleotide binding]; other site 93059001495 dimer interface [polypeptide binding]; other site 93059001496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93059001497 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 93059001498 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 93059001499 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 93059001500 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 93059001501 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93059001502 substrate binding site [chemical binding]; other site 93059001503 ATP binding site [chemical binding]; other site 93059001504 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 93059001505 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 93059001506 GDP-binding site [chemical binding]; other site 93059001507 ACT binding site; other site 93059001508 IMP binding site; other site 93059001509 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 93059001510 prolyl-tRNA synthetase; Provisional; Region: PRK09194 93059001511 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 93059001512 dimer interface [polypeptide binding]; other site 93059001513 motif 1; other site 93059001514 active site 93059001515 motif 2; other site 93059001516 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 93059001517 putative deacylase active site [active] 93059001518 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 93059001519 active site 93059001520 motif 3; other site 93059001521 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 93059001522 anticodon binding site; other site 93059001523 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 93059001524 dimer interface [polypeptide binding]; other site 93059001525 substrate binding site [chemical binding]; other site 93059001526 metal binding sites [ion binding]; metal-binding site 93059001527 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 93059001528 ArsC family; Region: ArsC; pfam03960 93059001529 putative ArsC-like catalytic residues; other site 93059001530 putative TRX-like catalytic residues [active] 93059001531 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93059001532 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93059001533 Catalytic site [active] 93059001534 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93059001535 dihydroorotase; Provisional; Region: PRK07369 93059001536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 93059001537 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 93059001538 active site 93059001539 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93059001540 catalytic core [active] 93059001541 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93059001542 catalytic core [active] 93059001543 CAAX protease self-immunity; Region: Abi; pfam02517 93059001544 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 93059001545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 93059001546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93059001547 transaldolase-like protein; Provisional; Region: PTZ00411 93059001548 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 93059001549 active site 93059001550 dimer interface [polypeptide binding]; other site 93059001551 catalytic residue [active] 93059001552 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 93059001553 ribosome recycling factor; Reviewed; Region: frr; PRK00083 93059001554 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 93059001555 hinge region; other site 93059001556 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 93059001557 putative nucleotide binding site [chemical binding]; other site 93059001558 uridine monophosphate binding site [chemical binding]; other site 93059001559 homohexameric interface [polypeptide binding]; other site 93059001560 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 93059001561 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 93059001562 homodimer interface [polypeptide binding]; other site 93059001563 Walker A motif; other site 93059001564 ATP binding site [chemical binding]; other site 93059001565 hydroxycobalamin binding site [chemical binding]; other site 93059001566 Walker B motif; other site 93059001567 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 93059001568 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 93059001569 active site 93059001570 catalytic residues [active] 93059001571 DNA binding site [nucleotide binding] 93059001572 Int/Topo IB signature motif; other site 93059001573 ferrochelatase; Reviewed; Region: hemH; PRK00035 93059001574 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 93059001575 C-terminal domain interface [polypeptide binding]; other site 93059001576 active site 93059001577 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 93059001578 active site 93059001579 N-terminal domain interface [polypeptide binding]; other site 93059001580 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 93059001581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 93059001582 PYR/PP interface [polypeptide binding]; other site 93059001583 dimer interface [polypeptide binding]; other site 93059001584 TPP binding site [chemical binding]; other site 93059001585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93059001586 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 93059001587 TPP-binding site [chemical binding]; other site 93059001588 dimer interface [polypeptide binding]; other site 93059001589 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 93059001590 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 93059001591 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 93059001592 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 93059001593 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 93059001594 RNA binding site [nucleotide binding]; other site 93059001595 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 93059001596 RNA binding site [nucleotide binding]; other site 93059001597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 93059001598 RNA binding site [nucleotide binding]; other site 93059001599 Creatinine amidohydrolase; Region: Creatininase; pfam02633 93059001600 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 93059001601 dinuclear metal binding motif [ion binding]; other site 93059001602 acyl-ACP reductase; Provisional; Region: PRK14982 93059001603 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 93059001604 NAD(P) binding pocket [chemical binding]; other site 93059001605 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 93059001606 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 93059001607 short chain dehydrogenase; Provisional; Region: PRK07454 93059001608 classical (c) SDRs; Region: SDR_c; cd05233 93059001609 NAD(P) binding site [chemical binding]; other site 93059001610 active site 93059001611 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 93059001612 active site 93059001613 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 93059001614 active site 93059001615 putative substrate binding region [chemical binding]; other site 93059001616 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 93059001617 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93059001618 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 93059001619 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 93059001620 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 93059001621 NAD(P) binding site [chemical binding]; other site 93059001622 active site 93059001623 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 93059001624 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 93059001625 P-loop; other site 93059001626 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 93059001627 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 93059001628 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 93059001629 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 93059001630 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 93059001631 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 93059001632 putative hexamer interface [polypeptide binding]; other site 93059001633 putative hexagonal pore; other site 93059001634 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 93059001635 putative hexamer interface [polypeptide binding]; other site 93059001636 putative hexagonal pore; other site 93059001637 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 93059001638 active site 93059001639 dimerization interface [polypeptide binding]; other site 93059001640 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 93059001641 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 93059001642 Hexamer interface [polypeptide binding]; other site 93059001643 Hexagonal pore residue; other site 93059001644 Hexagonal pore; other site 93059001645 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 93059001646 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 93059001647 dimer interface [polypeptide binding]; other site 93059001648 catalytic residue [active] 93059001649 metal binding site [ion binding]; metal-binding site 93059001650 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 93059001651 multimerization interface [polypeptide binding]; other site 93059001652 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 93059001653 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 93059001654 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 93059001655 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 93059001656 Hexamer/Pentamer interface [polypeptide binding]; other site 93059001657 central pore; other site 93059001658 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 93059001659 Hexamer/Pentamer interface [polypeptide binding]; other site 93059001660 central pore; other site 93059001661 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 93059001662 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 93059001663 Hexamer interface [polypeptide binding]; other site 93059001664 Hexagonal pore residue; other site 93059001665 Hexagonal pore; other site 93059001666 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 93059001667 aromatic arch; other site 93059001668 DCoH dimer interaction site [polypeptide binding]; other site 93059001669 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 93059001670 DCoH tetramer interaction site [polypeptide binding]; other site 93059001671 substrate binding site [chemical binding]; other site 93059001672 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 93059001673 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 93059001674 homotrimer interaction site [polypeptide binding]; other site 93059001675 putative active site [active] 93059001676 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 93059001677 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 93059001678 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 93059001679 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93059001680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93059001681 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 93059001682 Walker A/P-loop; other site 93059001683 ATP binding site [chemical binding]; other site 93059001684 Q-loop/lid; other site 93059001685 ABC transporter signature motif; other site 93059001686 Walker B; other site 93059001687 D-loop; other site 93059001688 H-loop/switch region; other site 93059001689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93059001690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93059001691 Coenzyme A binding pocket [chemical binding]; other site 93059001692 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 93059001693 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 93059001694 Probable Catalytic site; other site 93059001695 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 93059001696 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 93059001697 DnaA N-terminal domain; Region: DnaA_N; pfam11638 93059001698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059001699 Walker A motif; other site 93059001700 ATP binding site [chemical binding]; other site 93059001701 Walker B motif; other site 93059001702 arginine finger; other site 93059001703 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 93059001704 DnaA box-binding interface [nucleotide binding]; other site 93059001705 Putative ParB-like nuclease; Region: ParBc_2; cl17538 93059001706 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 93059001707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93059001708 C-terminal domain interface [polypeptide binding]; other site 93059001709 GSH binding site (G-site) [chemical binding]; other site 93059001710 dimer interface [polypeptide binding]; other site 93059001711 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 93059001712 N-terminal domain interface [polypeptide binding]; other site 93059001713 dimer interface [polypeptide binding]; other site 93059001714 substrate binding pocket (H-site) [chemical binding]; other site 93059001715 glutathione reductase; Validated; Region: PRK06116 93059001716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059001717 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 93059001718 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 93059001719 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 93059001720 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 93059001721 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 93059001722 active site 93059001723 substrate binding pocket [chemical binding]; other site 93059001724 dimer interface [polypeptide binding]; other site 93059001725 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 93059001726 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 93059001727 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 93059001728 substrate binding site [chemical binding]; other site 93059001729 active site 93059001730 catalytic residues [active] 93059001731 heterodimer interface [polypeptide binding]; other site 93059001732 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 93059001733 YciI-like protein; Reviewed; Region: PRK12864 93059001734 Cytochrome c; Region: Cytochrom_C; cl11414 93059001735 Uncharacterized conserved protein [Function unknown]; Region: COG3339 93059001736 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93059001737 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93059001738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93059001739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93059001740 DNA binding residues [nucleotide binding] 93059001741 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 93059001742 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 93059001743 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 93059001744 metal binding site [ion binding]; metal-binding site 93059001745 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93059001746 carotene isomerase; Region: carot_isom; TIGR02730 93059001747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93059001748 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 93059001749 Glucose inhibited division protein A; Region: GIDA; pfam01134 93059001750 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 93059001751 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93059001752 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 93059001753 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 93059001754 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 93059001755 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 93059001756 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 93059001757 Catalytic site; other site 93059001758 Staphylococcal nuclease homologue; Region: SNase; pfam00565 93059001759 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 93059001760 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 93059001761 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 93059001762 hypothetical protein; Validated; Region: PRK00029 93059001763 Uncharacterized conserved protein [Function unknown]; Region: COG0397 93059001764 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 93059001765 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 93059001766 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 93059001767 catalytic triad [active] 93059001768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 93059001769 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 93059001770 Uncharacterized conserved protein [Function unknown]; Region: COG4095 93059001771 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 93059001772 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 93059001773 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 93059001774 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 93059001775 putative di-iron ligands [ion binding]; other site 93059001776 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93059001777 ParA-like protein; Provisional; Region: PHA02518 93059001778 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 93059001779 P-loop; other site 93059001780 Magnesium ion binding site [ion binding]; other site 93059001781 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 93059001782 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 93059001783 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 93059001784 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 93059001785 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93059001786 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93059001787 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 93059001788 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 93059001789 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 93059001790 active site 93059001791 homodimer interface [polypeptide binding]; other site 93059001792 catalytic site [active] 93059001793 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 93059001794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93059001795 active site 93059001796 motif I; other site 93059001797 motif II; other site 93059001798 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 93059001799 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 93059001800 active site 93059001801 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 93059001802 T5orf172 domain; Region: T5orf172; pfam10544 93059001803 Bacitracin resistance protein BacA; Region: BacA; pfam02673 93059001804 PBP superfamily domain; Region: PBP_like_2; cl17296 93059001805 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 93059001806 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 93059001807 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93059001808 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93059001809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059001810 Walker A/P-loop; other site 93059001811 ATP binding site [chemical binding]; other site 93059001812 Q-loop/lid; other site 93059001813 ABC transporter signature motif; other site 93059001814 Walker B; other site 93059001815 D-loop; other site 93059001816 H-loop/switch region; other site 93059001817 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 93059001818 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 93059001819 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 93059001820 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 93059001821 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 93059001822 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 93059001823 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 93059001824 catalytic site [active] 93059001825 subunit interface [polypeptide binding]; other site 93059001826 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 93059001827 anti sigma factor interaction site; other site 93059001828 regulatory phosphorylation site [posttranslational modification]; other site 93059001829 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 93059001830 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 93059001831 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 93059001832 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93059001833 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 93059001834 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 93059001835 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 93059001836 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 93059001837 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 93059001838 active site 93059001839 PHP Thumb interface [polypeptide binding]; other site 93059001840 metal binding site [ion binding]; metal-binding site 93059001841 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 93059001842 generic binding surface I; other site 93059001843 generic binding surface II; other site 93059001844 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 93059001845 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 93059001846 16S/18S rRNA binding site [nucleotide binding]; other site 93059001847 S13e-L30e interaction site [polypeptide binding]; other site 93059001848 25S rRNA binding site [nucleotide binding]; other site 93059001849 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 93059001850 RuvA N terminal domain; Region: RuvA_N; pfam01330 93059001851 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 93059001852 EamA-like transporter family; Region: EamA; pfam00892 93059001853 EamA-like transporter family; Region: EamA; pfam00892 93059001854 DNA primase; Validated; Region: dnaG; PRK05667 93059001855 CHC2 zinc finger; Region: zf-CHC2; pfam01807 93059001856 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 93059001857 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 93059001858 active site 93059001859 metal binding site [ion binding]; metal-binding site 93059001860 interdomain interaction site; other site 93059001861 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 93059001862 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 93059001863 active site 93059001864 DNA binding site [nucleotide binding] 93059001865 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 93059001866 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 93059001867 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93059001868 Catalytic site [active] 93059001869 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 93059001870 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 93059001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059001872 S-adenosylmethionine binding site [chemical binding]; other site 93059001873 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 93059001874 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93059001875 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93059001876 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 93059001877 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 93059001878 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 93059001879 alpha subunit interface [polypeptide binding]; other site 93059001880 TPP binding site [chemical binding]; other site 93059001881 heterodimer interface [polypeptide binding]; other site 93059001882 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93059001883 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 93059001884 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 93059001885 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 93059001886 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 93059001887 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 93059001888 Protein export membrane protein; Region: SecD_SecF; cl14618 93059001889 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 93059001890 Domain of unknown function DUF20; Region: UPF0118; pfam01594 93059001891 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 93059001892 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 93059001893 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 93059001894 active site residue [active] 93059001895 GUN4-like; Region: GUN4; pfam05419 93059001896 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 93059001897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 93059001898 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 93059001899 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 93059001900 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 93059001901 active site 93059001902 catalytic site [active] 93059001903 substrate binding site [chemical binding]; other site 93059001904 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 93059001905 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 93059001906 dimer interface [polypeptide binding]; other site 93059001907 motif 1; other site 93059001908 active site 93059001909 motif 2; other site 93059001910 motif 3; other site 93059001911 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 93059001912 anticodon binding site; other site 93059001913 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 93059001914 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 93059001915 DNA binding residues [nucleotide binding] 93059001916 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059001917 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 93059001918 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93059001919 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93059001920 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 93059001921 putative N-terminal domain interface [polypeptide binding]; other site 93059001922 putative dimer interface [polypeptide binding]; other site 93059001923 putative substrate binding pocket (H-site) [chemical binding]; other site 93059001924 T5orf172 domain; Region: T5orf172; pfam10544 93059001925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059001926 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 93059001927 NAD(P) binding site [chemical binding]; other site 93059001928 active site 93059001929 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 93059001930 lycopene cyclase; Region: lycopene_cycl; TIGR01789 93059001931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059001932 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 93059001933 NAD(P) binding site [chemical binding]; other site 93059001934 active site 93059001935 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 93059001936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 93059001937 Isochorismatase family; Region: Isochorismatase; pfam00857 93059001938 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 93059001939 catalytic triad [active] 93059001940 dimer interface [polypeptide binding]; other site 93059001941 conserved cis-peptide bond; other site 93059001942 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93059001943 metal binding site 2 [ion binding]; metal-binding site 93059001944 putative DNA binding helix; other site 93059001945 metal binding site 1 [ion binding]; metal-binding site 93059001946 dimer interface [polypeptide binding]; other site 93059001947 structural Zn2+ binding site [ion binding]; other site 93059001948 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 93059001949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059001950 FeS/SAM binding site; other site 93059001951 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 93059001952 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 93059001953 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 93059001954 Phosphotransferase enzyme family; Region: APH; pfam01636 93059001955 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 93059001956 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 93059001957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93059001958 homodimer interface [polypeptide binding]; other site 93059001959 substrate-cofactor binding pocket; other site 93059001960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059001961 catalytic residue [active] 93059001962 Homoserine O-succinyltransferase; Region: HTS; pfam04204 93059001963 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 93059001964 proposed active site lysine [active] 93059001965 conserved cys residue [active] 93059001966 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 93059001967 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 93059001968 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 93059001969 Sulfate transporter family; Region: Sulfate_transp; pfam00916 93059001970 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 93059001971 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 93059001972 FAD binding domain; Region: FAD_binding_4; pfam01565 93059001973 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 93059001974 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 93059001975 putative active site [active] 93059001976 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 93059001977 putative active site [active] 93059001978 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 93059001979 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 93059001980 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 93059001981 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 93059001982 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93059001983 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059001984 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 93059001985 NmrA-like family; Region: NmrA; pfam05368 93059001986 NADP binding site [chemical binding]; other site 93059001987 active site 93059001988 regulatory binding site [polypeptide binding]; other site 93059001989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93059001990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 93059001991 Right handed beta helix region; Region: Beta_helix; pfam13229 93059001992 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 93059001993 putative metal binding residues [ion binding]; other site 93059001994 signature motif; other site 93059001995 dimer interface [polypeptide binding]; other site 93059001996 active site 93059001997 polyP binding site; other site 93059001998 substrate binding site [chemical binding]; other site 93059001999 acceptor-phosphate pocket; other site 93059002000 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 93059002001 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 93059002002 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 93059002003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059002004 S-adenosylmethionine binding site [chemical binding]; other site 93059002005 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 93059002006 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 93059002007 G1 box; other site 93059002008 putative GEF interaction site [polypeptide binding]; other site 93059002009 GTP/Mg2+ binding site [chemical binding]; other site 93059002010 Switch I region; other site 93059002011 G2 box; other site 93059002012 G3 box; other site 93059002013 Switch II region; other site 93059002014 G4 box; other site 93059002015 G5 box; other site 93059002016 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 93059002017 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 93059002018 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 93059002019 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 93059002020 dimerization interface [polypeptide binding]; other site 93059002021 domain crossover interface; other site 93059002022 redox-dependent activation switch; other site 93059002023 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 93059002024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93059002025 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 93059002026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 93059002027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93059002028 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93059002029 Walker A/P-loop; other site 93059002030 ATP binding site [chemical binding]; other site 93059002031 Q-loop/lid; other site 93059002032 ABC transporter signature motif; other site 93059002033 Walker B; other site 93059002034 D-loop; other site 93059002035 H-loop/switch region; other site 93059002036 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 93059002037 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 93059002038 Integral membrane protein DUF92; Region: DUF92; pfam01940 93059002039 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 93059002040 active site 93059002041 catalytic triad [active] 93059002042 oxyanion hole [active] 93059002043 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 93059002044 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 93059002045 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 93059002046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059002047 Walker A/P-loop; other site 93059002048 ATP binding site [chemical binding]; other site 93059002049 Q-loop/lid; other site 93059002050 ABC transporter signature motif; other site 93059002051 Walker B; other site 93059002052 D-loop; other site 93059002053 H-loop/switch region; other site 93059002054 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 93059002055 aspartate aminotransferase; Provisional; Region: PRK05764 93059002056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93059002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059002058 homodimer interface [polypeptide binding]; other site 93059002059 catalytic residue [active] 93059002060 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 93059002061 active site 93059002062 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 93059002063 Fe-S cluster binding site [ion binding]; other site 93059002064 active site 93059002065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 93059002066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 93059002067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 93059002068 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 93059002069 C-terminal peptidase (prc); Region: prc; TIGR00225 93059002070 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93059002071 protein binding site [polypeptide binding]; other site 93059002072 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 93059002073 Catalytic dyad [active] 93059002074 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 93059002075 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 93059002076 quinolinate synthetase; Provisional; Region: PRK09375 93059002077 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 93059002078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 93059002079 putative active site [active] 93059002080 putative metal binding site [ion binding]; other site 93059002081 Repair protein; Region: Repair_PSII; pfam04536 93059002082 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 93059002083 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 93059002084 active site 93059002085 dimer interface [polypeptide binding]; other site 93059002086 metal binding site [ion binding]; metal-binding site 93059002087 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 93059002088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93059002089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 93059002090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93059002091 adenylosuccinate synthase; Region: purA; TIGR00184 93059002092 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93059002093 Protein of unknown function (DUF938); Region: DUF938; pfam06080 93059002094 Uncharacterized conserved protein [Function unknown]; Region: COG2135 93059002095 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93059002096 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 93059002097 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 93059002098 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 93059002099 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 93059002100 Uncharacterized conserved protein (DUF2369); Region: DUF2369; pfam10179 93059002101 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 93059002102 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 93059002103 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 93059002104 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 93059002105 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 93059002106 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93059002107 Walker A motif; other site 93059002108 ATP binding site [chemical binding]; other site 93059002109 Walker B motif; other site 93059002110 Type II/IV secretion system protein; Region: T2SE; pfam00437 93059002111 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93059002112 Walker A motif; other site 93059002113 ATP binding site [chemical binding]; other site 93059002114 Walker B motif; other site 93059002115 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 93059002116 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 93059002117 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 93059002118 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 93059002119 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 93059002120 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 93059002121 Thf1-like protein; Reviewed; Region: PRK13266 93059002122 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 93059002123 Clp protease; Region: CLP_protease; pfam00574 93059002124 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93059002125 oligomer interface [polypeptide binding]; other site 93059002126 active site residues [active] 93059002127 cell division protein; Validated; Region: ftsH; CHL00176 93059002128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002129 Walker A motif; other site 93059002130 ATP binding site [chemical binding]; other site 93059002131 Walker B motif; other site 93059002132 arginine finger; other site 93059002133 Peptidase family M41; Region: Peptidase_M41; pfam01434 93059002134 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 93059002135 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 93059002136 pyruvate kinase; Provisional; Region: PRK06354 93059002137 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 93059002138 domain interfaces; other site 93059002139 active site 93059002140 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 93059002141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 93059002142 putative metal binding site [ion binding]; other site 93059002143 YGGT family; Region: YGGT; pfam02325 93059002144 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 93059002145 threonine dehydratase; Reviewed; Region: PRK09224 93059002146 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 93059002147 tetramer interface [polypeptide binding]; other site 93059002148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059002149 catalytic residue [active] 93059002150 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 93059002151 putative Ile/Val binding site [chemical binding]; other site 93059002152 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 93059002153 putative Ile/Val binding site [chemical binding]; other site 93059002154 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 93059002155 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 93059002156 TPP-binding site; other site 93059002157 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 93059002158 PYR/PP interface [polypeptide binding]; other site 93059002159 dimer interface [polypeptide binding]; other site 93059002160 TPP binding site [chemical binding]; other site 93059002161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93059002162 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 93059002163 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 93059002164 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 93059002165 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 93059002166 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93059002167 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93059002168 catalytic triad [active] 93059002169 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 93059002170 heat shock protein 90; Provisional; Region: PRK05218 93059002171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059002172 ATP binding site [chemical binding]; other site 93059002173 Mg2+ binding site [ion binding]; other site 93059002174 G-X-G motif; other site 93059002175 Ferredoxin [Energy production and conversion]; Region: COG1146 93059002176 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 93059002177 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 93059002178 dimer interface [polypeptide binding]; other site 93059002179 motif 1; other site 93059002180 active site 93059002181 motif 2; other site 93059002182 motif 3; other site 93059002183 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 93059002184 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 93059002185 active site 93059002186 dimerization interface [polypeptide binding]; other site 93059002187 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 93059002188 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 93059002189 Walker A/P-loop; other site 93059002190 ATP binding site [chemical binding]; other site 93059002191 Q-loop/lid; other site 93059002192 ABC transporter signature motif; other site 93059002193 Walker B; other site 93059002194 D-loop; other site 93059002195 H-loop/switch region; other site 93059002196 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 93059002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059002198 dimer interface [polypeptide binding]; other site 93059002199 conserved gate region; other site 93059002200 putative PBP binding loops; other site 93059002201 ABC-ATPase subunit interface; other site 93059002202 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 93059002203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059002204 dimer interface [polypeptide binding]; other site 93059002205 conserved gate region; other site 93059002206 putative PBP binding loops; other site 93059002207 ABC-ATPase subunit interface; other site 93059002208 molecular chaperone DnaK; Provisional; Region: PRK13410 93059002209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93059002210 nucleotide binding site [chemical binding]; other site 93059002211 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 93059002212 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93059002213 HSP70 interaction site [polypeptide binding]; other site 93059002214 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93059002215 substrate binding site [polypeptide binding]; other site 93059002216 dimer interface [polypeptide binding]; other site 93059002217 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 93059002218 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 93059002219 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 93059002220 putative active site [active] 93059002221 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 93059002222 active site 93059002223 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 93059002224 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 93059002225 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 93059002226 dimerization interface [polypeptide binding]; other site 93059002227 active site 93059002228 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 93059002229 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 93059002230 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 93059002231 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 93059002232 active site 93059002233 substrate binding site [chemical binding]; other site 93059002234 cosubstrate binding site; other site 93059002235 catalytic site [active] 93059002236 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 93059002237 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 93059002238 dimer interface [polypeptide binding]; other site 93059002239 active site 93059002240 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 93059002241 dimer interface [polypeptide binding]; other site 93059002242 active site 93059002243 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 93059002244 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 93059002245 HIGH motif; other site 93059002246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93059002247 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93059002248 active site 93059002249 KMSKS motif; other site 93059002250 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 93059002251 tRNA binding surface [nucleotide binding]; other site 93059002252 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93059002253 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 93059002254 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 93059002255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 93059002256 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 93059002257 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 93059002258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059002259 catalytic residue [active] 93059002260 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 93059002261 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 93059002262 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 93059002263 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 93059002264 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 93059002265 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 93059002266 active site 93059002267 (T/H)XGH motif; other site 93059002268 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 93059002269 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 93059002270 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 93059002271 GIY-YIG motif/motif A; other site 93059002272 active site 93059002273 catalytic site [active] 93059002274 putative DNA binding site [nucleotide binding]; other site 93059002275 metal binding site [ion binding]; metal-binding site 93059002276 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 93059002277 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 93059002278 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 93059002279 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 93059002280 active site 93059002281 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93059002282 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 93059002283 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93059002284 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 93059002285 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 93059002286 homodimer interface [polypeptide binding]; other site 93059002287 substrate-cofactor binding pocket; other site 93059002288 catalytic residue [active] 93059002289 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 93059002290 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 93059002291 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 93059002292 substrate binding pocket [chemical binding]; other site 93059002293 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 93059002294 B12 binding site [chemical binding]; other site 93059002295 cobalt ligand [ion binding]; other site 93059002296 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 93059002297 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 93059002298 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 93059002299 ATP adenylyltransferase; Region: ATP_transf; pfam09830 93059002300 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 93059002301 HSP70 interaction site [polypeptide binding]; other site 93059002302 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 93059002303 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 93059002304 putative tRNA-binding site [nucleotide binding]; other site 93059002305 B3/4 domain; Region: B3_4; pfam03483 93059002306 tRNA synthetase B5 domain; Region: B5; smart00874 93059002307 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 93059002308 dimer interface [polypeptide binding]; other site 93059002309 motif 1; other site 93059002310 motif 3; other site 93059002311 motif 2; other site 93059002312 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 93059002313 ribosomal protein L33; Region: rpl33; CHL00104 93059002314 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 93059002315 RNB domain; Region: RNB; pfam00773 93059002316 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 93059002317 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 93059002318 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 93059002319 active site 93059002320 HIGH motif; other site 93059002321 KMSKS motif; other site 93059002322 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 93059002323 tRNA binding surface [nucleotide binding]; other site 93059002324 anticodon binding site; other site 93059002325 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 93059002326 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 93059002327 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 93059002328 homotrimer interface [polypeptide binding]; other site 93059002329 Walker A motif; other site 93059002330 GTP binding site [chemical binding]; other site 93059002331 Walker B motif; other site 93059002332 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 93059002333 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93059002334 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 93059002335 dimer interface [polypeptide binding]; other site 93059002336 decamer (pentamer of dimers) interface [polypeptide binding]; other site 93059002337 catalytic triad [active] 93059002338 peroxidatic and resolving cysteines [active] 93059002339 hypothetical protein; Provisional; Region: PRK02509 93059002340 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 93059002341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002342 Walker A motif; other site 93059002343 ATP binding site [chemical binding]; other site 93059002344 Walker B motif; other site 93059002345 arginine finger; other site 93059002346 Peptidase family M41; Region: Peptidase_M41; pfam01434 93059002347 ribosomal protein L32; Validated; Region: rpl32; CHL00152 93059002348 Protein of unknown function (DUF565); Region: DUF565; pfam04483 93059002349 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 93059002350 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 93059002351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93059002352 motif II; other site 93059002353 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 93059002354 DHH family; Region: DHH; pfam01368 93059002355 DHHA1 domain; Region: DHHA1; pfam02272 93059002356 similar to hypothetical protein 93059002357 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 93059002358 Predicted membrane protein [Function unknown]; Region: COG2119 93059002359 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 93059002360 Predicted membrane protein [Function unknown]; Region: COG2119 93059002361 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 93059002362 Exoribonuclease R [Transcription]; Region: VacB; COG0557 93059002363 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 93059002364 RNB domain; Region: RNB; pfam00773 93059002365 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 93059002366 RNA binding site [nucleotide binding]; other site 93059002367 aromatic acid decarboxylase; Validated; Region: PRK05920 93059002368 Flavoprotein; Region: Flavoprotein; pfam02441 93059002369 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 93059002370 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 93059002371 dinuclear metal binding motif [ion binding]; other site 93059002372 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93059002373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93059002374 catalytic loop [active] 93059002375 iron binding site [ion binding]; other site 93059002376 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 93059002377 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 93059002378 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 93059002379 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 93059002380 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 93059002381 putative active site [active] 93059002382 substrate binding site [chemical binding]; other site 93059002383 putative cosubstrate binding site; other site 93059002384 catalytic site [active] 93059002385 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 93059002386 substrate binding site [chemical binding]; other site 93059002387 Integral membrane protein TerC family; Region: TerC; cl10468 93059002388 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 93059002389 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 93059002390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059002391 ATP binding site [chemical binding]; other site 93059002392 putative Mg++ binding site [ion binding]; other site 93059002393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059002394 nucleotide binding region [chemical binding]; other site 93059002395 ATP-binding site [chemical binding]; other site 93059002396 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 93059002397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93059002398 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 93059002399 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 93059002400 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 93059002401 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 93059002402 dihydrodipicolinate reductase; Provisional; Region: PRK00048 93059002403 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 93059002404 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 93059002405 magnesium chelatase subunit H; Provisional; Region: PRK12493 93059002406 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 93059002407 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93059002408 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93059002409 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 93059002410 dihydropteroate synthase; Region: DHPS; TIGR01496 93059002411 substrate binding pocket [chemical binding]; other site 93059002412 dimer interface [polypeptide binding]; other site 93059002413 inhibitor binding site; inhibition site 93059002414 triosephosphate isomerase; Provisional; Region: PRK14565 93059002415 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 93059002416 substrate binding site [chemical binding]; other site 93059002417 dimer interface [polypeptide binding]; other site 93059002418 catalytic triad [active] 93059002419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059002420 RNA binding surface [nucleotide binding]; other site 93059002421 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93059002422 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93059002423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059002424 Walker A/P-loop; other site 93059002425 ATP binding site [chemical binding]; other site 93059002426 Q-loop/lid; other site 93059002427 ABC transporter signature motif; other site 93059002428 Walker B; other site 93059002429 D-loop; other site 93059002430 H-loop/switch region; other site 93059002431 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 93059002432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93059002433 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93059002434 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 93059002435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93059002436 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93059002437 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 93059002438 IMP binding site; other site 93059002439 dimer interface [polypeptide binding]; other site 93059002440 interdomain contacts; other site 93059002441 partial ornithine binding site; other site 93059002442 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 93059002443 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 93059002444 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 93059002445 L-asparaginase II; Region: Asparaginase_II; pfam06089 93059002446 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 93059002447 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 93059002448 [2Fe-2S] cluster binding site [ion binding]; other site 93059002449 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 93059002450 hydrophobic ligand binding site; other site 93059002451 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 93059002452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059002453 Walker A/P-loop; other site 93059002454 ATP binding site [chemical binding]; other site 93059002455 Q-loop/lid; other site 93059002456 ABC transporter signature motif; other site 93059002457 Walker B; other site 93059002458 D-loop; other site 93059002459 H-loop/switch region; other site 93059002460 transcription initiation factor IIB; Reviewed; Region: tfb; PRK00423 93059002461 tartrate dehydrogenase; Provisional; Region: PRK08194 93059002462 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059002463 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 93059002464 non-specific DNA interactions [nucleotide binding]; other site 93059002465 DNA binding site [nucleotide binding] 93059002466 sequence specific DNA binding site [nucleotide binding]; other site 93059002467 putative cAMP binding site [chemical binding]; other site 93059002468 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 93059002469 Ferritin-like domain; Region: Ferritin; pfam00210 93059002470 ferroxidase diiron center [ion binding]; other site 93059002471 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 93059002472 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 93059002473 Walker A/P-loop; other site 93059002474 ATP binding site [chemical binding]; other site 93059002475 Q-loop/lid; other site 93059002476 ABC transporter signature motif; other site 93059002477 Walker B; other site 93059002478 D-loop; other site 93059002479 H-loop/switch region; other site 93059002480 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 93059002481 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93059002482 minor groove reading motif; other site 93059002483 helix-hairpin-helix signature motif; other site 93059002484 substrate binding pocket [chemical binding]; other site 93059002485 active site 93059002486 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 93059002487 NADH(P)-binding; Region: NAD_binding_10; pfam13460 93059002488 NAD(P) binding site [chemical binding]; other site 93059002489 putative active site [active] 93059002490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93059002491 Coenzyme A binding pocket [chemical binding]; other site 93059002492 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 93059002493 trimer interface [polypeptide binding]; other site 93059002494 putative Zn binding site [ion binding]; other site 93059002495 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 93059002496 GSH binding site [chemical binding]; other site 93059002497 catalytic residues [active] 93059002498 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 93059002499 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93059002500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059002501 NAD(P) binding site [chemical binding]; other site 93059002502 active site 93059002503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059002504 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 93059002505 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 93059002506 catalytic residues [active] 93059002507 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 93059002508 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 93059002509 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 93059002510 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 93059002511 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 93059002512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93059002513 active site 93059002514 motif I; other site 93059002515 motif II; other site 93059002516 gamma-glutamyl kinase; Provisional; Region: PRK05429 93059002517 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 93059002518 nucleotide binding site [chemical binding]; other site 93059002519 homotetrameric interface [polypeptide binding]; other site 93059002520 putative phosphate binding site [ion binding]; other site 93059002521 putative allosteric binding site; other site 93059002522 PUA domain; Region: PUA; pfam01472 93059002523 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 93059002524 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 93059002525 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 93059002526 trimer interface [polypeptide binding]; other site 93059002527 active site 93059002528 UDP-GlcNAc binding site [chemical binding]; other site 93059002529 lipid binding site [chemical binding]; lipid-binding site 93059002530 tartrate dehydrogenase; Region: TTC; TIGR02089 93059002531 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 93059002532 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 93059002533 active site 93059002534 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 93059002535 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 93059002536 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 93059002537 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93059002538 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93059002539 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 93059002540 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 93059002541 intersubunit interface [polypeptide binding]; other site 93059002542 active site 93059002543 zinc binding site [ion binding]; other site 93059002544 Na+ binding site [ion binding]; other site 93059002545 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 93059002546 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 93059002547 putative active site [active] 93059002548 catalytic triad [active] 93059002549 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 93059002550 chaperone protein DnaJ; Provisional; Region: PRK14276 93059002551 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 93059002552 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 93059002553 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93059002554 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93059002555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059002556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059002557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 93059002558 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 93059002559 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 93059002560 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 93059002561 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 93059002562 putative active site [active] 93059002563 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 93059002564 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 93059002565 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 93059002566 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 93059002567 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 93059002568 ligand binding site; other site 93059002569 oligomer interface; other site 93059002570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93059002571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93059002572 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 93059002573 dimer interface [polypeptide binding]; other site 93059002574 N-terminal domain interface [polypeptide binding]; other site 93059002575 sulfate 1 binding site; other site 93059002576 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 93059002577 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 93059002578 tRNA; other site 93059002579 putative tRNA binding site [nucleotide binding]; other site 93059002580 putative NADP binding site [chemical binding]; other site 93059002581 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 93059002582 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 93059002583 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 93059002584 putative active site [active] 93059002585 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 93059002586 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 93059002587 substrate binding site [chemical binding]; other site 93059002588 hexamer interface [polypeptide binding]; other site 93059002589 metal binding site [ion binding]; metal-binding site 93059002590 cytochrome c biogenesis protein; Region: ccsA; CHL00045 93059002591 Predicted permeases [General function prediction only]; Region: COG0795 93059002592 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 93059002593 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 93059002594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059002595 Walker A/P-loop; other site 93059002596 ATP binding site [chemical binding]; other site 93059002597 Q-loop/lid; other site 93059002598 ABC transporter signature motif; other site 93059002599 Walker B; other site 93059002600 D-loop; other site 93059002601 H-loop/switch region; other site 93059002602 Domain of unknown function (DUF309); Region: DUF309; pfam03745 93059002603 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 93059002604 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 93059002605 G1 box; other site 93059002606 putative GEF interaction site [polypeptide binding]; other site 93059002607 GTP/Mg2+ binding site [chemical binding]; other site 93059002608 Switch I region; other site 93059002609 G2 box; other site 93059002610 G3 box; other site 93059002611 Switch II region; other site 93059002612 G4 box; other site 93059002613 G5 box; other site 93059002614 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 93059002615 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 93059002616 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 93059002617 geranylgeranyl reductase; Region: ChlP; TIGR02028 93059002618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93059002619 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 93059002620 sulfite reductase subunit beta; Provisional; Region: PRK13504 93059002621 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 93059002622 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 93059002623 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 93059002624 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 93059002625 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 93059002626 generic binding surface II; other site 93059002627 ssDNA binding site; other site 93059002628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059002629 ATP binding site [chemical binding]; other site 93059002630 putative Mg++ binding site [ion binding]; other site 93059002631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059002632 nucleotide binding region [chemical binding]; other site 93059002633 ATP-binding site [chemical binding]; other site 93059002634 elongation factor Ts; Reviewed; Region: tsf; PRK12332 93059002635 UBA/TS-N domain; Region: UBA; pfam00627 93059002636 Elongation factor TS; Region: EF_TS; pfam00889 93059002637 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 93059002638 rRNA interaction site [nucleotide binding]; other site 93059002639 S8 interaction site; other site 93059002640 putative laminin-1 binding site; other site 93059002641 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 93059002642 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 93059002643 active site 93059002644 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 93059002645 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 93059002646 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93059002647 Walker A/P-loop; other site 93059002648 ATP binding site [chemical binding]; other site 93059002649 Q-loop/lid; other site 93059002650 ABC transporter signature motif; other site 93059002651 Walker B; other site 93059002652 D-loop; other site 93059002653 H-loop/switch region; other site 93059002654 DevC protein; Region: devC; TIGR01185 93059002655 FtsX-like permease family; Region: FtsX; pfam02687 93059002656 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 93059002657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 93059002658 HlyD family secretion protein; Region: HlyD_3; pfam13437 93059002659 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 93059002660 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93059002661 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 93059002662 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93059002663 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93059002664 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 93059002665 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93059002666 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 93059002667 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 93059002668 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 93059002669 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 93059002670 GTP/Mg2+ binding site [chemical binding]; other site 93059002671 G5 box; other site 93059002672 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 93059002673 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 93059002674 G1 box; other site 93059002675 G1 box; other site 93059002676 GTP/Mg2+ binding site [chemical binding]; other site 93059002677 Switch I region; other site 93059002678 Switch I region; other site 93059002679 G2 box; other site 93059002680 G2 box; other site 93059002681 Switch II region; other site 93059002682 G3 box; other site 93059002683 G3 box; other site 93059002684 Switch II region; other site 93059002685 G4 box; other site 93059002686 G5 box; other site 93059002687 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93059002688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93059002689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059002690 catalytic residue [active] 93059002691 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 93059002692 nucleoside/Zn binding site; other site 93059002693 dimer interface [polypeptide binding]; other site 93059002694 catalytic motif [active] 93059002695 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 93059002696 homodimer interface [polypeptide binding]; other site 93059002697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059002698 catalytic residue [active] 93059002699 glutamine synthetase, type I; Region: GlnA; TIGR00653 93059002700 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 93059002701 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 93059002702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93059002703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059002704 S-adenosylmethionine binding site [chemical binding]; other site 93059002705 acetyl-CoA synthetase; Provisional; Region: PRK00174 93059002706 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 93059002707 active site 93059002708 CoA binding site [chemical binding]; other site 93059002709 acyl-activating enzyme (AAE) consensus motif; other site 93059002710 AMP binding site [chemical binding]; other site 93059002711 acetate binding site [chemical binding]; other site 93059002712 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 93059002713 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93059002714 substrate binding pocket [chemical binding]; other site 93059002715 chain length determination region; other site 93059002716 substrate-Mg2+ binding site; other site 93059002717 catalytic residues [active] 93059002718 aspartate-rich region 1; other site 93059002719 active site lid residues [active] 93059002720 aspartate-rich region 2; other site 93059002721 glutamate racemase; Provisional; Region: PRK00865 93059002722 AMIN domain; Region: AMIN; pfam11741 93059002723 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 93059002724 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 93059002725 active site 93059002726 metal binding site [ion binding]; metal-binding site 93059002727 nitrilase; Region: PLN02798 93059002728 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 93059002729 putative active site [active] 93059002730 catalytic triad [active] 93059002731 dimer interface [polypeptide binding]; other site 93059002732 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 93059002733 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 93059002734 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 93059002735 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 93059002736 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 93059002737 hinge; other site 93059002738 active site 93059002739 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 93059002740 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 93059002741 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 93059002742 Substrate binding site; other site 93059002743 Mg++ binding site; other site 93059002744 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 93059002745 active site 93059002746 substrate binding site [chemical binding]; other site 93059002747 CoA binding site [chemical binding]; other site 93059002748 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93059002749 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 93059002750 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93059002751 glycogen synthase; Provisional; Region: glgA; PRK00654 93059002752 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 93059002753 ADP-binding pocket [chemical binding]; other site 93059002754 homodimer interface [polypeptide binding]; other site 93059002755 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 93059002756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 93059002757 substrate binding site [chemical binding]; other site 93059002758 oxyanion hole (OAH) forming residues; other site 93059002759 trimer interface [polypeptide binding]; other site 93059002760 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 93059002761 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 93059002762 dimer interface [polypeptide binding]; other site 93059002763 tetramer interface [polypeptide binding]; other site 93059002764 PYR/PP interface [polypeptide binding]; other site 93059002765 TPP binding site [chemical binding]; other site 93059002766 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 93059002767 TPP-binding site; other site 93059002768 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93059002769 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93059002770 Catalytic site [active] 93059002771 Protein of unknown function (DUF760); Region: DUF760; pfam05542 93059002772 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 93059002773 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 93059002774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93059002775 ABC-ATPase subunit interface; other site 93059002776 dimer interface [polypeptide binding]; other site 93059002777 putative PBP binding regions; other site 93059002778 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 93059002779 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93059002780 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 93059002781 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 93059002782 metal binding site [ion binding]; metal-binding site 93059002783 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93059002784 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 93059002785 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 93059002786 active site 93059002787 HIGH motif; other site 93059002788 dimer interface [polypeptide binding]; other site 93059002789 KMSKS motif; other site 93059002790 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 93059002791 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 93059002792 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 93059002793 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 93059002794 active site 93059002795 dimer interface [polypeptide binding]; other site 93059002796 motif 1; other site 93059002797 motif 2; other site 93059002798 motif 3; other site 93059002799 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 93059002800 anticodon binding site; other site 93059002801 Glucokinase; Region: Glucokinase; pfam02685 93059002802 glucokinase, proteobacterial type; Region: glk; TIGR00749 93059002803 homoserine kinase; Provisional; Region: PRK01212 93059002804 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93059002805 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 93059002806 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93059002807 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 93059002808 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 93059002809 active site 93059002810 Zn binding site [ion binding]; other site 93059002811 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 93059002812 Dihydroneopterin aldolase; Region: FolB; pfam02152 93059002813 active site 93059002814 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 93059002815 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 93059002816 putative catalytic cysteine [active] 93059002817 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 93059002818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93059002819 nucleotide binding site [chemical binding]; other site 93059002820 Family of unknown function (DUF490); Region: DUF490; pfam04357 93059002821 Protein of function (DUF2518); Region: DUF2518; pfam10726 93059002822 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 93059002823 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 93059002824 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 93059002825 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 93059002826 glycogen branching enzyme; Provisional; Region: PRK05402 93059002827 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 93059002828 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 93059002829 active site 93059002830 catalytic site [active] 93059002831 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 93059002832 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 93059002833 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 93059002834 substrate binding site [chemical binding]; other site 93059002835 active site 93059002836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059002837 NADH(P)-binding; Region: NAD_binding_10; pfam13460 93059002838 NAD(P) binding site [chemical binding]; other site 93059002839 active site 93059002840 plastocyanin; Provisional; Region: PRK02710 93059002841 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 93059002842 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 93059002843 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 93059002844 Clp amino terminal domain; Region: Clp_N; pfam02861 93059002845 Clp amino terminal domain; Region: Clp_N; pfam02861 93059002846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002847 Walker A motif; other site 93059002848 ATP binding site [chemical binding]; other site 93059002849 Walker B motif; other site 93059002850 arginine finger; other site 93059002851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002852 Walker A motif; other site 93059002853 ATP binding site [chemical binding]; other site 93059002854 Walker B motif; other site 93059002855 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93059002856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93059002857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93059002858 active site 93059002859 phosphorylation site [posttranslational modification] 93059002860 intermolecular recognition site; other site 93059002861 dimerization interface [polypeptide binding]; other site 93059002862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93059002863 DNA binding site [nucleotide binding] 93059002864 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 93059002865 putative GSH binding site [chemical binding]; other site 93059002866 catalytic residues [active] 93059002867 BolA-like protein; Region: BolA; pfam01722 93059002868 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 93059002869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 93059002870 putative acyl-acceptor binding pocket; other site 93059002871 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 93059002872 active site 93059002873 hydrophilic channel; other site 93059002874 dimerization interface [polypeptide binding]; other site 93059002875 catalytic residues [active] 93059002876 active site lid [active] 93059002877 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 93059002878 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 93059002879 Phospholipid methyltransferase; Region: PEMT; cl17370 93059002880 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 93059002881 Part of AAA domain; Region: AAA_19; pfam13245 93059002882 Family description; Region: UvrD_C_2; pfam13538 93059002883 AAA domain; Region: AAA_30; pfam13604 93059002884 Family description; Region: UvrD_C_2; pfam13538 93059002885 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 93059002886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 93059002887 ATP binding site [chemical binding]; other site 93059002888 Mg++ binding site [ion binding]; other site 93059002889 motif III; other site 93059002890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059002891 nucleotide binding region [chemical binding]; other site 93059002892 ATP-binding site [chemical binding]; other site 93059002893 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 93059002894 putative RNA binding site [nucleotide binding]; other site 93059002895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93059002896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93059002897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059002898 Walker A/P-loop; other site 93059002899 ATP binding site [chemical binding]; other site 93059002900 Q-loop/lid; other site 93059002901 ABC transporter signature motif; other site 93059002902 Walker B; other site 93059002903 D-loop; other site 93059002904 H-loop/switch region; other site 93059002905 PsbP; Region: PsbP; pfam01789 93059002906 recombination protein RecR; Reviewed; Region: recR; PRK00076 93059002907 RecR protein; Region: RecR; pfam02132 93059002908 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 93059002909 putative active site [active] 93059002910 putative metal-binding site [ion binding]; other site 93059002911 tetramer interface [polypeptide binding]; other site 93059002912 lipoyl synthase; Provisional; Region: PRK12928 93059002913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059002914 FeS/SAM binding site; other site 93059002915 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 93059002916 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 93059002917 active site residue [active] 93059002918 biotin synthase; Region: bioB; TIGR00433 93059002919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059002920 FeS/SAM binding site; other site 93059002921 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 93059002922 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14831 93059002923 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 93059002924 catalytic residue [active] 93059002925 putative FPP diphosphate binding site; other site 93059002926 putative FPP binding hydrophobic cleft; other site 93059002927 dimer interface [polypeptide binding]; other site 93059002928 putative IPP diphosphate binding site; other site 93059002929 Uncharacterized conserved protein [Function unknown]; Region: COG1624 93059002930 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 93059002931 diaminopimelate decarboxylase; Region: lysA; TIGR01048 93059002932 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 93059002933 active site 93059002934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93059002935 substrate binding site [chemical binding]; other site 93059002936 catalytic residues [active] 93059002937 dimer interface [polypeptide binding]; other site 93059002938 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 93059002939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93059002940 Coenzyme A binding pocket [chemical binding]; other site 93059002941 Clp protease ATP binding subunit; Region: clpC; CHL00095 93059002942 Clp amino terminal domain; Region: Clp_N; pfam02861 93059002943 Clp amino terminal domain; Region: Clp_N; pfam02861 93059002944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002945 Walker A motif; other site 93059002946 ATP binding site [chemical binding]; other site 93059002947 Walker B motif; other site 93059002948 arginine finger; other site 93059002949 UvrB/uvrC motif; Region: UVR; pfam02151 93059002950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059002951 Walker A motif; other site 93059002952 ATP binding site [chemical binding]; other site 93059002953 Walker B motif; other site 93059002954 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93059002955 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 93059002956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 93059002957 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 93059002958 phosphatidate cytidylyltransferase; Region: PLN02953 93059002959 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 93059002960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93059002961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059002962 catalytic residue [active] 93059002963 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 93059002964 ABC1 family; Region: ABC1; cl17513 93059002965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059002966 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 93059002967 RNA binding surface [nucleotide binding]; other site 93059002968 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 93059002969 active site 93059002970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93059002971 non-specific DNA binding site [nucleotide binding]; other site 93059002972 salt bridge; other site 93059002973 sequence-specific DNA binding site [nucleotide binding]; other site 93059002974 4-alpha-glucanotransferase; Provisional; Region: PRK14508 93059002975 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 93059002976 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 93059002977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059002978 active site 93059002979 adaptive-response sensory kinase; Validated; Region: PRK09303 93059002980 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 93059002981 tetramer interface [polypeptide binding]; other site 93059002982 dimer interface [polypeptide binding]; other site 93059002983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93059002984 dimer interface [polypeptide binding]; other site 93059002985 phosphorylation site [posttranslational modification] 93059002986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059002987 ATP binding site [chemical binding]; other site 93059002988 Mg2+ binding site [ion binding]; other site 93059002989 G-X-G motif; other site 93059002990 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 93059002991 hydrophobic ligand binding site; other site 93059002992 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 93059002993 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 93059002994 dimerization interface [polypeptide binding]; other site 93059002995 FAD binding pocket [chemical binding]; other site 93059002996 FAD binding motif [chemical binding]; other site 93059002997 catalytic residues [active] 93059002998 NAD binding pocket [chemical binding]; other site 93059002999 phosphate binding motif [ion binding]; other site 93059003000 beta-alpha-beta structure motif; other site 93059003001 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 93059003002 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 93059003003 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 93059003004 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 93059003005 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 93059003006 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 93059003007 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 93059003008 catalytic triad [active] 93059003009 AAA domain; Region: AAA_30; pfam13604 93059003010 Family description; Region: UvrD_C_2; pfam13538 93059003011 Divergent PAP2 family; Region: DUF212; pfam02681 93059003012 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 93059003013 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93059003014 substrate binding pocket [chemical binding]; other site 93059003015 chain length determination region; other site 93059003016 substrate-Mg2+ binding site; other site 93059003017 catalytic residues [active] 93059003018 aspartate-rich region 1; other site 93059003019 active site lid residues [active] 93059003020 aspartate-rich region 2; other site 93059003021 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 93059003022 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 93059003023 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 93059003024 homodimer interface [polypeptide binding]; other site 93059003025 NADP binding site [chemical binding]; other site 93059003026 substrate binding site [chemical binding]; other site 93059003027 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 93059003028 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 93059003029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93059003030 Zn2+ binding site [ion binding]; other site 93059003031 Mg2+ binding site [ion binding]; other site 93059003032 Domain of unknown function DUF77; Region: DUF77; pfam01910 93059003033 2-isopropylmalate synthase; Validated; Region: PRK00915 93059003034 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 93059003035 active site 93059003036 catalytic residues [active] 93059003037 metal binding site [ion binding]; metal-binding site 93059003038 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 93059003039 Uncharacterized conserved protein [Function unknown]; Region: COG1543 93059003040 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 93059003041 active site 93059003042 substrate binding site [chemical binding]; other site 93059003043 catalytic site [active] 93059003044 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 93059003045 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 93059003046 DNA gyrase subunit A; Validated; Region: PRK05560 93059003047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93059003048 CAP-like domain; other site 93059003049 active site 93059003050 primary dimer interface [polypeptide binding]; other site 93059003051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93059003057 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 93059003058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 93059003059 active site 93059003060 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93059003061 catalytic residues [active] 93059003062 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 93059003063 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 93059003064 putative active site [active] 93059003065 oxyanion strand; other site 93059003066 catalytic triad [active] 93059003067 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 93059003068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059003069 S-adenosylmethionine binding site [chemical binding]; other site 93059003070 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 93059003071 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 93059003072 Cytochrome c; Region: Cytochrom_C; pfam00034 93059003073 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 93059003074 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93059003075 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 93059003076 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 93059003077 AAA ATPase domain; Region: AAA_16; pfam13191 93059003078 Walker A motif; other site 93059003079 ATP binding site [chemical binding]; other site 93059003080 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 93059003081 active site 93059003082 putative DNA-binding cleft [nucleotide binding]; other site 93059003083 dimer interface [polypeptide binding]; other site 93059003084 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 93059003085 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 93059003086 Fe-S metabolism associated domain; Region: SufE; cl00951 93059003087 homoserine dehydrogenase; Provisional; Region: PRK06349 93059003088 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 93059003089 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 93059003090 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 93059003091 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 93059003092 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 93059003093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93059003094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059003095 dimer interface [polypeptide binding]; other site 93059003096 conserved gate region; other site 93059003097 putative PBP binding loops; other site 93059003098 ABC-ATPase subunit interface; other site 93059003099 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 93059003100 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 93059003101 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 93059003102 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 93059003103 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93059003104 substrate binding site [chemical binding]; other site 93059003105 ATP binding site [chemical binding]; other site 93059003106 Adenylate kinase, active site lid; Region: ADK_lid; pfam05191 93059003107 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93059003108 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059003109 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 93059003110 flavodoxin FldA; Validated; Region: PRK09267 93059003111 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059003112 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059003113 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059003114 putative high light inducible protein; Region: PHA02337 93059003115 putative high light inducible protein; Region: PHA02337 93059003116 putative high light inducible protein; Region: PHA02337 93059003117 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 93059003118 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 93059003119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93059003120 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 93059003121 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 93059003122 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 93059003123 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 93059003124 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 93059003125 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 93059003126 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 93059003127 ATP-grasp domain; Region: ATP-grasp; pfam02222 93059003128 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 93059003129 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 93059003130 catalytic residues [active] 93059003131 dimer interface [polypeptide binding]; other site 93059003132 Protein of unknown function, DUF393; Region: DUF393; pfam04134 93059003133 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 93059003134 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 93059003135 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93059003136 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 93059003137 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 93059003138 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 93059003139 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 93059003140 Membrane transport protein; Region: Mem_trans; cl09117 93059003141 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 93059003142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059003143 Walker A/P-loop; other site 93059003144 ATP binding site [chemical binding]; other site 93059003145 Q-loop/lid; other site 93059003146 ABC transporter signature motif; other site 93059003147 Walker B; other site 93059003148 D-loop; other site 93059003149 H-loop/switch region; other site 93059003150 ABC transporter; Region: ABC_tran_2; pfam12848 93059003151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059003152 Walker A/P-loop; other site 93059003153 ATP binding site [chemical binding]; other site 93059003154 Q-loop/lid; other site 93059003155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93059003156 ABC transporter signature motif; other site 93059003157 Walker B; other site 93059003158 D-loop; other site 93059003159 putative assembly protein; Provisional; Region: PRK10833 93059003160 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 93059003161 putative amphipathic alpha helix; other site 93059003162 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93059003163 PspC domain; Region: PspC; pfam04024 93059003164 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 93059003165 GTP-binding protein YchF; Reviewed; Region: PRK09601 93059003166 YchF GTPase; Region: YchF; cd01900 93059003167 G1 box; other site 93059003168 GTP/Mg2+ binding site [chemical binding]; other site 93059003169 Switch I region; other site 93059003170 G2 box; other site 93059003171 Switch II region; other site 93059003172 G3 box; other site 93059003173 G4 box; other site 93059003174 G5 box; other site 93059003175 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 93059003176 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 93059003177 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 93059003178 HlyD family secretion protein; Region: HlyD_3; pfam13437 93059003179 DNA polymerase I; Provisional; Region: PRK05755 93059003180 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 93059003181 active site 93059003182 metal binding site 1 [ion binding]; metal-binding site 93059003183 putative 5' ssDNA interaction site; other site 93059003184 metal binding site 3; metal-binding site 93059003185 metal binding site 2 [ion binding]; metal-binding site 93059003186 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 93059003187 putative DNA binding site [nucleotide binding]; other site 93059003188 putative metal binding site [ion binding]; other site 93059003189 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 93059003190 active site 93059003191 catalytic site [active] 93059003192 substrate binding site [chemical binding]; other site 93059003193 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 93059003194 active site 93059003195 DNA binding site [nucleotide binding] 93059003196 catalytic site [active] 93059003197 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 93059003198 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 93059003199 active site 93059003200 HIGH motif; other site 93059003201 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 93059003202 KMSKS motif; other site 93059003203 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93059003204 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 93059003205 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 93059003206 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 93059003207 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 93059003208 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 93059003209 dimer interface [polypeptide binding]; other site 93059003210 [2Fe-2S] cluster binding site [ion binding]; other site 93059003211 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 93059003212 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 93059003213 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 93059003214 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 93059003215 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 93059003216 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 93059003217 ligand binding site [chemical binding]; other site 93059003218 homodimer interface [polypeptide binding]; other site 93059003219 NAD(P) binding site [chemical binding]; other site 93059003220 trimer interface B [polypeptide binding]; other site 93059003221 trimer interface A [polypeptide binding]; other site 93059003222 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 93059003223 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93059003224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059003225 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93059003226 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 93059003227 rRNA binding site [nucleotide binding]; other site 93059003228 predicted 30S ribosome binding site; other site 93059003229 Ycf39; Provisional; Region: ycf39; CHL00194 93059003230 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 93059003231 NAD(P) binding site [chemical binding]; other site 93059003232 putative active site [active] 93059003233 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 93059003234 hydrolase, alpha/beta fold family protein; Region: PLN02824 93059003235 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 93059003236 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 93059003237 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 93059003238 putative valine binding site [chemical binding]; other site 93059003239 dimer interface [polypeptide binding]; other site 93059003240 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 93059003241 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 93059003242 active site 93059003243 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 93059003244 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 93059003245 pheophytin binding site; other site 93059003246 chlorophyll binding site; other site 93059003247 quinone binding site; other site 93059003248 Fe binding site [ion binding]; other site 93059003249 Photosystem II protein; Region: PSII; cl08223 93059003250 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 93059003251 Maf-like protein; Region: Maf; pfam02545 93059003252 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 93059003253 active site 93059003254 dimer interface [polypeptide binding]; other site 93059003255 cobyric acid synthase; Provisional; Region: PRK00784 93059003256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93059003257 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 93059003258 catalytic triad [active] 93059003259 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93059003260 catalytic loop [active] 93059003261 iron binding site [ion binding]; other site 93059003262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 93059003263 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93059003264 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 93059003265 Substrate binding site; other site 93059003266 metal-binding site 93059003267 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 93059003268 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 93059003269 NAD binding site [chemical binding]; other site 93059003270 substrate binding site [chemical binding]; other site 93059003271 active site 93059003272 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 93059003273 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 93059003274 inhibitor-cofactor binding pocket; inhibition site 93059003275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059003276 catalytic residue [active] 93059003277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93059003278 active site 93059003279 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 93059003280 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 93059003281 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 93059003282 active site 93059003283 homodimer interface [polypeptide binding]; other site 93059003284 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 93059003285 NeuB family; Region: NeuB; pfam03102 93059003286 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 93059003287 NeuB binding interface [polypeptide binding]; other site 93059003288 putative substrate binding site [chemical binding]; other site 93059003289 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 93059003290 active site 93059003291 cosubstrate binding site; other site 93059003292 substrate binding site [chemical binding]; other site 93059003293 catalytic site [active] 93059003294 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 93059003295 TPR repeat; Region: TPR_11; pfam13414 93059003296 TPR repeat; Region: TPR_11; pfam13414 93059003297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003298 binding surface 93059003299 TPR motif; other site 93059003300 TPR repeat; Region: TPR_11; pfam13414 93059003301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003302 binding surface 93059003303 TPR motif; other site 93059003304 TPR repeat; Region: TPR_11; pfam13414 93059003305 TPR repeat; Region: TPR_11; pfam13414 93059003306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003307 binding surface 93059003308 TPR repeat; Region: TPR_11; pfam13414 93059003309 TPR motif; other site 93059003310 TPR repeat; Region: TPR_11; pfam13414 93059003311 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 93059003312 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 93059003313 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 93059003314 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 93059003315 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 93059003316 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 93059003317 dimer interface [polypeptide binding]; other site 93059003318 motif 1; other site 93059003319 active site 93059003320 motif 2; other site 93059003321 motif 3; other site 93059003322 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 93059003323 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 93059003324 Ligand binding site; other site 93059003325 Putative Catalytic site; other site 93059003326 DXD motif; other site 93059003327 Predicted membrane protein [Function unknown]; Region: COG2246 93059003328 GtrA-like protein; Region: GtrA; pfam04138 93059003329 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93059003330 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 93059003331 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 93059003332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93059003333 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 93059003334 putative ADP-binding pocket [chemical binding]; other site 93059003335 EamA-like transporter family; Region: EamA; pfam00892 93059003336 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 93059003337 EamA-like transporter family; Region: EamA; pfam00892 93059003338 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 93059003339 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 93059003340 tandem repeat interface [polypeptide binding]; other site 93059003341 oligomer interface [polypeptide binding]; other site 93059003342 active site residues [active] 93059003343 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 93059003344 homotrimer interaction site [polypeptide binding]; other site 93059003345 active site 93059003346 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 93059003347 Ribonuclease P; Region: Ribonuclease_P; cl00457 93059003348 Bacterial PH domain; Region: DUF304; pfam03703 93059003349 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 93059003350 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 93059003351 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 93059003352 Ycf46; Provisional; Region: ycf46; CHL00195 93059003353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059003354 Walker A motif; other site 93059003355 ATP binding site [chemical binding]; other site 93059003356 Walker B motif; other site 93059003357 arginine finger; other site 93059003358 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 93059003359 seryl-tRNA synthetase; Provisional; Region: PRK05431 93059003360 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 93059003361 dimer interface [polypeptide binding]; other site 93059003362 active site 93059003363 motif 1; other site 93059003364 motif 2; other site 93059003365 motif 3; other site 93059003366 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 93059003367 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 93059003368 active site 93059003369 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 93059003370 protein binding site [polypeptide binding]; other site 93059003371 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 93059003372 putative substrate binding region [chemical binding]; other site 93059003373 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 93059003374 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 93059003375 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 93059003376 RNase E interface [polypeptide binding]; other site 93059003377 trimer interface [polypeptide binding]; other site 93059003378 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 93059003379 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 93059003380 RNase E interface [polypeptide binding]; other site 93059003381 trimer interface [polypeptide binding]; other site 93059003382 active site 93059003383 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 93059003384 putative nucleic acid binding region [nucleotide binding]; other site 93059003385 G-X-X-G motif; other site 93059003386 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 93059003387 RNA binding site [nucleotide binding]; other site 93059003388 domain interface; other site 93059003389 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 93059003390 active site 93059003391 Predicted methyltransferases [General function prediction only]; Region: COG0313 93059003392 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 93059003393 putative SAM binding site [chemical binding]; other site 93059003394 putative homodimer interface [polypeptide binding]; other site 93059003395 UDP-glucose 4-epimerase; Region: PLN02240 93059003396 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 93059003397 NAD binding site [chemical binding]; other site 93059003398 homodimer interface [polypeptide binding]; other site 93059003399 active site 93059003400 substrate binding site [chemical binding]; other site 93059003401 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 93059003402 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93059003403 putative NAD(P) binding site [chemical binding]; other site 93059003404 active site 93059003405 putative substrate binding site [chemical binding]; other site 93059003406 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 93059003407 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 93059003408 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 93059003409 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 93059003410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93059003411 active site 93059003412 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 93059003413 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 93059003414 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 93059003415 ligand binding site [chemical binding]; other site 93059003416 NAD binding site [chemical binding]; other site 93059003417 catalytic site [active] 93059003418 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 93059003419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059003420 NAD(P) binding site [chemical binding]; other site 93059003421 active site 93059003422 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93059003423 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 93059003424 substrate binding site; other site 93059003425 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93059003426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059003427 NAD(P) binding site [chemical binding]; other site 93059003428 active site 93059003429 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 93059003430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93059003431 active site 93059003432 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 93059003433 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 93059003434 Ligand binding site; other site 93059003435 oligomer interface; other site 93059003436 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 93059003437 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 93059003438 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 93059003439 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 93059003440 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 93059003441 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93059003442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93059003443 motif II; other site 93059003444 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 93059003445 D-lactate dehydrogenase; Provisional; Region: PRK11183 93059003446 FAD binding domain; Region: FAD_binding_4; pfam01565 93059003447 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 93059003448 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 93059003449 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 93059003450 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93059003451 Catalytic site [active] 93059003452 ornithine carbamoyltransferase; Provisional; Region: PRK00779 93059003453 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93059003454 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93059003455 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 93059003456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059003457 Walker A motif; other site 93059003458 ATP binding site [chemical binding]; other site 93059003459 Walker B motif; other site 93059003460 arginine finger; other site 93059003461 Peptidase family M41; Region: Peptidase_M41; pfam01434 93059003462 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 93059003463 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 93059003464 catalytic motif [active] 93059003465 Zn binding site [ion binding]; other site 93059003466 RibD C-terminal domain; Region: RibD_C; cl17279 93059003467 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 93059003468 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 93059003469 active site 93059003470 putative homodimer interface [polypeptide binding]; other site 93059003471 SAM binding site [chemical binding]; other site 93059003472 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 93059003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059003474 S-adenosylmethionine binding site [chemical binding]; other site 93059003475 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 93059003476 ATP-NAD kinase; Region: NAD_kinase; pfam01513 93059003477 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 93059003478 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 93059003479 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 93059003480 dimer interface [polypeptide binding]; other site 93059003481 motif 1; other site 93059003482 active site 93059003483 motif 2; other site 93059003484 motif 3; other site 93059003485 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 93059003486 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 93059003487 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 93059003488 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 93059003489 active site 93059003490 Riboflavin kinase; Region: Flavokinase; smart00904 93059003491 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 93059003492 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 93059003493 thiamine phosphate binding site [chemical binding]; other site 93059003494 active site 93059003495 pyrophosphate binding site [ion binding]; other site 93059003496 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 93059003497 thiS-thiF/thiG interaction site; other site 93059003498 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 93059003499 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 93059003500 AIR carboxylase; Region: AIRC; smart01001 93059003501 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 93059003502 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 93059003503 homotrimer interaction site [polypeptide binding]; other site 93059003504 zinc binding site [ion binding]; other site 93059003505 CDP-binding sites; other site 93059003506 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 93059003507 GTPase Era; Reviewed; Region: era; PRK00089 93059003508 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 93059003509 G1 box; other site 93059003510 GTP/Mg2+ binding site [chemical binding]; other site 93059003511 Switch I region; other site 93059003512 G2 box; other site 93059003513 Switch II region; other site 93059003514 G3 box; other site 93059003515 G4 box; other site 93059003516 G5 box; other site 93059003517 KH domain; Region: KH_2; pfam07650 93059003518 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 93059003519 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 93059003520 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 93059003521 PhoH-like protein; Region: PhoH; pfam02562 93059003522 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 93059003523 signal recognition particle protein; Provisional; Region: PRK10867 93059003524 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 93059003525 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 93059003526 P loop; other site 93059003527 GTP binding site [chemical binding]; other site 93059003528 Signal peptide binding domain; Region: SRP_SPB; pfam02978 93059003529 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 93059003530 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 93059003531 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 93059003532 tetramer interface [polypeptide binding]; other site 93059003533 TPP-binding site [chemical binding]; other site 93059003534 heterodimer interface [polypeptide binding]; other site 93059003535 phosphorylation loop region [posttranslational modification] 93059003536 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93059003537 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93059003538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93059003539 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93059003540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93059003541 DNA binding residues [nucleotide binding] 93059003542 Uncharacterized conserved protein [Function unknown]; Region: COG0062 93059003543 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 93059003544 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 93059003545 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 93059003546 Ligand Binding Site [chemical binding]; other site 93059003547 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 93059003548 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 93059003549 putative active site [active] 93059003550 catalytic triad [active] 93059003551 putative dimer interface [polypeptide binding]; other site 93059003552 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 93059003553 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 93059003554 superoxide dismutase, Ni; Region: sodN; TIGR02753 93059003555 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93059003556 Catalytic site [active] 93059003557 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 93059003558 active site 93059003559 ribulose/triose binding site [chemical binding]; other site 93059003560 phosphate binding site [ion binding]; other site 93059003561 substrate (anthranilate) binding pocket [chemical binding]; other site 93059003562 product (indole) binding pocket [chemical binding]; other site 93059003563 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 93059003564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93059003565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059003566 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 93059003567 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 93059003568 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 93059003569 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93059003570 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 93059003571 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 93059003572 hinge; other site 93059003573 active site 93059003574 acetylornithine aminotransferase; Provisional; Region: PRK02627 93059003575 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93059003576 inhibitor-cofactor binding pocket; inhibition site 93059003577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059003578 catalytic residue [active] 93059003579 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 93059003580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93059003581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 93059003582 FAD binding domain; Region: FAD_binding_4; pfam01565 93059003583 cytosine deaminase-like protein; Validated; Region: PRK07583 93059003584 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 93059003585 active site 93059003586 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 93059003587 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93059003588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059003589 FeS/SAM binding site; other site 93059003590 TRAM domain; Region: TRAM; cl01282 93059003591 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 93059003592 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 93059003593 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 93059003594 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 93059003595 cell division protein FtsZ; Validated; Region: PRK09330 93059003596 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 93059003597 nucleotide binding site [chemical binding]; other site 93059003598 SulA interaction site; other site 93059003599 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 93059003600 oligomerization interface [polypeptide binding]; other site 93059003601 active site 93059003602 metal binding site [ion binding]; metal-binding site 93059003603 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 93059003604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059003605 FeS/SAM binding site; other site 93059003606 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 93059003607 putative active site [active] 93059003608 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 93059003609 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93059003610 oligomer interface [polypeptide binding]; other site 93059003611 active site residues [active] 93059003612 Clp protease; Region: CLP_protease; pfam00574 93059003613 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93059003614 oligomer interface [polypeptide binding]; other site 93059003615 active site residues [active] 93059003616 ketol-acid reductoisomerase; Provisional; Region: PRK05479 93059003617 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 93059003618 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 93059003619 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 93059003620 Bacterial sugar transferase; Region: Bac_transf; pfam02397 93059003621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93059003622 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 93059003623 putative ADP-binding pocket [chemical binding]; other site 93059003624 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 93059003625 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 93059003626 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 93059003627 active site 93059003628 HIGH motif; other site 93059003629 nucleotide binding site [chemical binding]; other site 93059003630 active site 93059003631 KMSKS motif; other site 93059003632 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 93059003633 IHF dimer interface [polypeptide binding]; other site 93059003634 IHF - DNA interface [nucleotide binding]; other site 93059003635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93059003636 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 93059003637 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 93059003638 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 93059003639 active site 93059003640 catalytic site [active] 93059003641 MFS/sugar transport protein; Region: MFS_2; pfam13347 93059003642 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 93059003643 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 93059003644 Permease; Region: Permease; pfam02405 93059003645 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 93059003646 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 93059003647 membrane protein; Provisional; Region: PRK14419 93059003648 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 93059003649 active site 93059003650 dimer interface [polypeptide binding]; other site 93059003651 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 93059003652 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 93059003653 active site 93059003654 HIGH motif; other site 93059003655 dimer interface [polypeptide binding]; other site 93059003656 KMSKS motif; other site 93059003657 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059003658 RNA binding surface [nucleotide binding]; other site 93059003659 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 93059003660 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 93059003661 multifunctional aminopeptidase A; Provisional; Region: PRK00913 93059003662 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 93059003663 interface (dimer of trimers) [polypeptide binding]; other site 93059003664 Substrate-binding/catalytic site; other site 93059003665 Zn-binding sites [ion binding]; other site 93059003666 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 93059003667 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 93059003668 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 93059003669 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 93059003670 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 93059003671 active site 93059003672 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 93059003673 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 93059003674 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 93059003675 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 93059003676 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 93059003677 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 93059003678 Surface antigen; Region: Bac_surface_Ag; pfam01103 93059003679 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 93059003680 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 93059003681 ATP binding site [chemical binding]; other site 93059003682 active site 93059003683 substrate binding site [chemical binding]; other site 93059003684 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 93059003685 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 93059003686 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 93059003687 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 93059003688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 93059003689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 93059003690 dimerization interface [polypeptide binding]; other site 93059003691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 93059003692 putative active site [active] 93059003693 heme pocket [chemical binding]; other site 93059003694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93059003695 dimer interface [polypeptide binding]; other site 93059003696 phosphorylation site [posttranslational modification] 93059003697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059003698 ATP binding site [chemical binding]; other site 93059003699 Mg2+ binding site [ion binding]; other site 93059003700 G-X-G motif; other site 93059003701 circadian clock protein KaiC; Reviewed; Region: PRK09302 93059003702 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 93059003703 Walker A motif; other site 93059003704 ATP binding site [chemical binding]; other site 93059003705 Walker B motif; other site 93059003706 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93059003707 Walker A motif; other site 93059003708 ATP binding site [chemical binding]; other site 93059003709 Walker B motif; other site 93059003710 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 93059003711 tetramer interface [polypeptide binding]; other site 93059003712 dimer interface [polypeptide binding]; other site 93059003713 ribosomal protein L21; Region: rpl21; CHL00075 93059003714 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 93059003715 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 93059003716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059003717 S-adenosylmethionine binding site [chemical binding]; other site 93059003718 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 93059003719 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 93059003720 RNA binding site [nucleotide binding]; other site 93059003721 active site 93059003722 Stage II sporulation protein; Region: SpoIID; pfam08486 93059003723 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 93059003724 ribonuclease Z; Region: RNase_Z; TIGR02651 93059003725 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93059003726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059003727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93059003728 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93059003729 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93059003730 catalytic loop [active] 93059003731 iron binding site [ion binding]; other site 93059003732 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 93059003733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059003734 S-adenosylmethionine binding site [chemical binding]; other site 93059003735 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 93059003736 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 93059003737 ligand binding site [chemical binding]; other site 93059003738 NAD binding site [chemical binding]; other site 93059003739 dimerization interface [polypeptide binding]; other site 93059003740 catalytic site [active] 93059003741 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 93059003742 putative L-serine binding site [chemical binding]; other site 93059003743 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 93059003744 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 93059003745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059003746 RNA binding surface [nucleotide binding]; other site 93059003747 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 93059003748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93059003749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93059003750 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93059003751 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 93059003752 Uncharacterized conserved protein [Function unknown]; Region: COG4095 93059003753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93059003754 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 93059003755 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93059003756 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 93059003757 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93059003758 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 93059003759 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059003760 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 93059003761 putative substrate binding site 2 [chemical binding]; other site 93059003762 putative substrate binding site 1 [chemical binding]; other site 93059003763 Na binding site 1 [ion binding]; other site 93059003764 Na2 binding site [ion binding]; other site 93059003765 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 93059003766 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 93059003767 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 93059003768 Ion channel; Region: Ion_trans_2; pfam07885 93059003769 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93059003770 TrkA-N domain; Region: TrkA_N; pfam02254 93059003771 Tetratricopeptide repeat; Region: TPR_12; pfam13424 93059003772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003773 binding surface 93059003774 TPR motif; other site 93059003775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 93059003776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003777 binding surface 93059003778 TPR motif; other site 93059003779 TPR repeat; Region: TPR_11; pfam13414 93059003780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 93059003781 binding surface 93059003782 TPR motif; other site 93059003783 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 93059003784 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 93059003785 hypothetical protein; Provisional; Region: PRK09256 93059003786 Protein of unknown function, DUF393; Region: DUF393; pfam04134 93059003787 Helix-turn-helix domain; Region: HTH_25; pfam13413 93059003788 C factor cell-cell signaling protein; Provisional; Region: PRK09009 93059003789 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 93059003790 NADP binding site [chemical binding]; other site 93059003791 homodimer interface [polypeptide binding]; other site 93059003792 active site 93059003793 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93059003794 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93059003795 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 93059003796 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 93059003797 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93059003798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93059003799 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93059003800 short chain dehydrogenase; Provisional; Region: PRK06197 93059003801 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 93059003802 putative NAD(P) binding site [chemical binding]; other site 93059003803 active site 93059003804 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 93059003805 GTP cyclohydrolase I; Provisional; Region: PLN03044 93059003806 active site 93059003807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059003808 active site 93059003809 putative high light inducible protein; Region: PHA02337 93059003810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 93059003811 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 93059003812 Walker A/P-loop; other site 93059003813 ATP binding site [chemical binding]; other site 93059003814 Q-loop/lid; other site 93059003815 ABC transporter signature motif; other site 93059003816 Walker B; other site 93059003817 D-loop; other site 93059003818 H-loop/switch region; other site 93059003819 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 93059003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059003821 dimer interface [polypeptide binding]; other site 93059003822 conserved gate region; other site 93059003823 putative PBP binding loops; other site 93059003824 ABC-ATPase subunit interface; other site 93059003825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93059003826 dimer interface [polypeptide binding]; other site 93059003827 conserved gate region; other site 93059003828 putative PBP binding loops; other site 93059003829 ABC-ATPase subunit interface; other site 93059003830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 93059003831 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 93059003832 membrane-bound complex binding site; other site 93059003833 hinge residues; other site 93059003834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 93059003835 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 93059003836 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 93059003837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93059003838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059003839 active site 93059003840 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 93059003841 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 93059003842 Ligand Binding Site [chemical binding]; other site 93059003843 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 93059003844 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 93059003845 substrate binding site [chemical binding]; other site 93059003846 glutamase interaction surface [polypeptide binding]; other site 93059003847 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 93059003848 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 93059003849 putative active site [active] 93059003850 oxyanion strand; other site 93059003851 catalytic triad [active] 93059003852 TIGR03032 family protein; Region: TIGR03032 93059003853 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 93059003854 Ligand Binding Site [chemical binding]; other site 93059003855 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 93059003856 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 93059003857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93059003858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93059003859 DNA binding residues [nucleotide binding] 93059003860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93059003861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059003862 ATP binding site [chemical binding]; other site 93059003863 Mg2+ binding site [ion binding]; other site 93059003864 G-X-G motif; other site 93059003865 OsmC-like protein; Region: OsmC; pfam02566 93059003866 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 93059003867 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 93059003868 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 93059003869 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93059003870 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93059003871 catalytic triad [active] 93059003872 putative high light inducible protein; Region: PHA02337 93059003873 putative high light inducible protein; Region: PHA02337 93059003874 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 93059003875 FOG: WD40 repeat [General function prediction only]; Region: COG2319 93059003876 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 93059003877 structural tetrad; other site 93059003878 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93059003879 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 93059003880 P-loop, Walker A motif; other site 93059003881 Base recognition motif; other site 93059003882 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93059003883 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 93059003884 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 93059003885 region that could not be sequenced 93059003886 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 93059003887 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93059003888 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93059003889 metal binding site 2 [ion binding]; metal-binding site 93059003890 putative DNA binding helix; other site 93059003891 metal binding site 1 [ion binding]; metal-binding site 93059003892 dimer interface [polypeptide binding]; other site 93059003893 structural Zn2+ binding site [ion binding]; other site 93059003894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 93059003895 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 93059003896 putative PBP binding regions; other site 93059003897 ABC-ATPase subunit interface; other site 93059003898 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 93059003899 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 93059003900 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 93059003901 DNA binding site [nucleotide binding] 93059003902 Int/Topo IB signature motif; other site 93059003903 active site 93059003904 catalytic residues [active] 93059003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003906 TPR repeat; Region: TPR_11; pfam13414 93059003907 TPR motif; other site 93059003908 TPR repeat; Region: TPR_11; pfam13414 93059003909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003910 binding surface 93059003911 TPR motif; other site 93059003912 TPR repeat; Region: TPR_11; pfam13414 93059003913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059003914 binding surface 93059003915 TPR motif; other site 93059003916 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 93059003917 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 93059003918 Walker A motif; other site 93059003919 ATP binding site [chemical binding]; other site 93059003920 Walker B motif; other site 93059003921 DNA binding loops [nucleotide binding] 93059003922 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003923 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003924 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003925 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003926 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003927 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003928 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003929 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003930 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003931 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003932 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003933 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003934 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003935 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003936 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003937 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003938 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003939 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003940 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003941 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003942 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 93059003943 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 93059003944 T5orf172 domain; Region: T5orf172; pfam10544 93059003945 OsmC-like protein; Region: OsmC; pfam02566 93059003946 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 93059003947 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93059003948 protein binding site [polypeptide binding]; other site 93059003949 EVE domain; Region: EVE; cl00728 93059003950 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 93059003951 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 93059003952 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 93059003953 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 93059003954 nucleotide binding site [chemical binding]; other site 93059003955 putative NEF/HSP70 interaction site [polypeptide binding]; other site 93059003956 SBD interface [polypeptide binding]; other site 93059003957 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 93059003958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93059003959 active site 93059003960 phosphoglyceromutase; Provisional; Region: PRK05434 93059003961 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 93059003962 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 93059003963 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 93059003964 ring oligomerisation interface [polypeptide binding]; other site 93059003965 ATP/Mg binding site [chemical binding]; other site 93059003966 stacking interactions; other site 93059003967 hinge regions; other site 93059003968 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 93059003969 oligomerisation interface [polypeptide binding]; other site 93059003970 mobile loop; other site 93059003971 roof hairpin; other site 93059003972 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 93059003973 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93059003974 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 93059003975 alpha subunit interaction interface [polypeptide binding]; other site 93059003976 Walker A motif; other site 93059003977 ATP binding site [chemical binding]; other site 93059003978 Walker B motif; other site 93059003979 inhibitor binding site; inhibition site 93059003980 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93059003981 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 93059003982 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 93059003983 gamma subunit interface [polypeptide binding]; other site 93059003984 epsilon subunit interface [polypeptide binding]; other site 93059003985 LBP interface [polypeptide binding]; other site 93059003986 hypothetical protein; Provisional; Region: PRK02724 93059003987 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93059003988 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 93059003989 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 93059003990 proline aminopeptidase P II; Provisional; Region: PRK10879 93059003991 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 93059003992 active site 93059003993 Domain of unknown function DUF21; Region: DUF21; pfam01595 93059003994 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 93059003995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93059003996 Dynamin family; Region: Dynamin_N; pfam00350 93059003997 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 93059003998 G1 box; other site 93059003999 GTP/Mg2+ binding site [chemical binding]; other site 93059004000 Switch I region; other site 93059004001 G2 box; other site 93059004002 Switch II region; other site 93059004003 G3 box; other site 93059004004 G4 box; other site 93059004005 G5 box; other site 93059004006 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93059004007 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 93059004008 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 93059004009 active site 93059004010 (T/H)XGH motif; other site 93059004011 NAD synthetase; Provisional; Region: PRK13981 93059004012 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 93059004013 multimer interface [polypeptide binding]; other site 93059004014 active site 93059004015 catalytic triad [active] 93059004016 protein interface 1 [polypeptide binding]; other site 93059004017 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 93059004018 homodimer interface [polypeptide binding]; other site 93059004019 NAD binding pocket [chemical binding]; other site 93059004020 ATP binding pocket [chemical binding]; other site 93059004021 Mg binding site [ion binding]; other site 93059004022 active-site loop [active] 93059004023 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 93059004024 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 93059004025 core domain interface [polypeptide binding]; other site 93059004026 delta subunit interface [polypeptide binding]; other site 93059004027 epsilon subunit interface [polypeptide binding]; other site 93059004028 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 93059004029 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93059004030 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 93059004031 beta subunit interaction interface [polypeptide binding]; other site 93059004032 Walker A motif; other site 93059004033 ATP binding site [chemical binding]; other site 93059004034 Walker B motif; other site 93059004035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93059004036 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 93059004037 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 93059004038 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 93059004039 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 93059004040 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 93059004041 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 93059004042 ATP synthase CF0 C subunit; Region: atpH; CHL00061 93059004043 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 93059004044 ATP synthase CF0 A subunit; Region: atpI; CHL00046 93059004045 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 93059004046 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 93059004047 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 93059004048 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 93059004049 ResB-like family; Region: ResB; pfam05140 93059004050 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 93059004051 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 93059004052 Nitrogen regulatory protein P-II; Region: P-II; smart00938 93059004053 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 93059004054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93059004055 RNA binding surface [nucleotide binding]; other site 93059004056 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 93059004057 adenylosuccinate lyase; Provisional; Region: PRK07380 93059004058 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 93059004059 tetramer interface [polypeptide binding]; other site 93059004060 active site 93059004061 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 93059004062 fumarate hydratase; Reviewed; Region: fumC; PRK00485 93059004063 Class II fumarases; Region: Fumarase_classII; cd01362 93059004064 active site 93059004065 tetramer interface [polypeptide binding]; other site 93059004066 DEAD-like helicases superfamily; Region: DEXDc; smart00487 93059004067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059004068 ATP binding site [chemical binding]; other site 93059004069 putative Mg++ binding site [ion binding]; other site 93059004070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059004071 nucleotide binding region [chemical binding]; other site 93059004072 ATP-binding site [chemical binding]; other site 93059004073 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 93059004074 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 93059004075 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 93059004076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93059004077 catalytic residue [active] 93059004078 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 93059004079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93059004080 AAA domain; Region: AAA_26; pfam13500 93059004081 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 93059004082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93059004083 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 93059004084 inhibitor-cofactor binding pocket; inhibition site 93059004085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004086 catalytic residue [active] 93059004087 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 93059004088 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 93059004089 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93059004090 HSP70 interaction site [polypeptide binding]; other site 93059004091 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 93059004092 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 93059004093 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 93059004094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93059004095 active site 93059004096 catalytic tetrad [active] 93059004097 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 93059004098 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 93059004099 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 93059004100 HEAT repeats; Region: HEAT_2; pfam13646 93059004101 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 93059004102 Na binding site [ion binding]; other site 93059004103 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 93059004104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059004105 FeS/SAM binding site; other site 93059004106 light-harvesting-like protein 3; Provisional; Region: PLN00014 93059004107 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 93059004108 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 93059004109 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 93059004110 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 93059004111 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 93059004112 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 93059004113 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 93059004114 G-loop; other site 93059004115 DNA binding site [nucleotide binding] 93059004116 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 93059004117 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 93059004118 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 93059004119 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 93059004120 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 93059004121 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 93059004122 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 93059004123 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 93059004124 RPB1 interaction site [polypeptide binding]; other site 93059004125 RPB10 interaction site [polypeptide binding]; other site 93059004126 RPB11 interaction site [polypeptide binding]; other site 93059004127 RPB3 interaction site [polypeptide binding]; other site 93059004128 RPB12 interaction site [polypeptide binding]; other site 93059004129 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 93059004130 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 93059004131 active site 93059004132 ribosomal protein S20; Region: rps20; CHL00102 93059004133 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 93059004134 histidinol dehydrogenase; Region: hisD; TIGR00069 93059004135 NAD binding site [chemical binding]; other site 93059004136 dimerization interface [polypeptide binding]; other site 93059004137 product binding site; other site 93059004138 substrate binding site [chemical binding]; other site 93059004139 zinc binding site [ion binding]; other site 93059004140 catalytic residues [active] 93059004141 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 93059004142 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93059004143 active site 93059004144 dimer interface [polypeptide binding]; other site 93059004145 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 93059004146 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93059004147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93059004148 protein binding site [polypeptide binding]; other site 93059004149 Sm and related proteins; Region: Sm_like; cl00259 93059004150 ribosome maturation protein RimP; Reviewed; Region: PRK00092 93059004151 NusA N-terminal domain; Region: NusA_N; pfam08529 93059004152 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 93059004153 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 93059004154 RNA binding site [nucleotide binding]; other site 93059004155 homodimer interface [polypeptide binding]; other site 93059004156 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 93059004157 G-X-X-G motif; other site 93059004158 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 93059004159 G-X-X-G motif; other site 93059004160 Protein of unknown function (DUF448); Region: DUF448; pfam04296 93059004161 putative RNA binding cleft [nucleotide binding]; other site 93059004162 translation initiation factor IF-2; Region: IF-2; TIGR00487 93059004163 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 93059004164 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 93059004165 G1 box; other site 93059004166 putative GEF interaction site [polypeptide binding]; other site 93059004167 GTP/Mg2+ binding site [chemical binding]; other site 93059004168 Switch I region; other site 93059004169 G2 box; other site 93059004170 G3 box; other site 93059004171 Switch II region; other site 93059004172 G4 box; other site 93059004173 G5 box; other site 93059004174 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 93059004175 Translation-initiation factor 2; Region: IF-2; pfam11987 93059004176 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 93059004177 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 93059004178 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 93059004179 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 93059004180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059004181 FeS/SAM binding site; other site 93059004182 CAAX protease self-immunity; Region: Abi; pfam02517 93059004183 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 93059004184 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 93059004185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93059004186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004187 homodimer interface [polypeptide binding]; other site 93059004188 catalytic residue [active] 93059004189 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 93059004190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059004191 FeS/SAM binding site; other site 93059004192 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 93059004193 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 93059004194 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 93059004195 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 93059004196 homodimer interface [polypeptide binding]; other site 93059004197 oligonucleotide binding site [chemical binding]; other site 93059004198 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 93059004199 RNA/DNA hybrid binding site [nucleotide binding]; other site 93059004200 active site 93059004201 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 93059004202 prephenate dehydratase; Provisional; Region: PRK11898 93059004203 Prephenate dehydratase; Region: PDT; pfam00800 93059004204 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 93059004205 putative L-Phe binding site [chemical binding]; other site 93059004206 tocopherol O-methyltransferase; Region: PLN02244 93059004207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059004208 S-adenosylmethionine binding site [chemical binding]; other site 93059004209 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 93059004210 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 93059004211 elongation factor Tu; Reviewed; Region: PRK00049 93059004212 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 93059004213 G1 box; other site 93059004214 GEF interaction site [polypeptide binding]; other site 93059004215 GTP/Mg2+ binding site [chemical binding]; other site 93059004216 Switch I region; other site 93059004217 G2 box; other site 93059004218 G3 box; other site 93059004219 Switch II region; other site 93059004220 G4 box; other site 93059004221 G5 box; other site 93059004222 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 93059004223 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 93059004224 Antibiotic Binding Site [chemical binding]; other site 93059004225 elongation factor G; Reviewed; Region: PRK00007 93059004226 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 93059004227 G1 box; other site 93059004228 putative GEF interaction site [polypeptide binding]; other site 93059004229 GTP/Mg2+ binding site [chemical binding]; other site 93059004230 Switch I region; other site 93059004231 G2 box; other site 93059004232 G3 box; other site 93059004233 Switch II region; other site 93059004234 G4 box; other site 93059004235 G5 box; other site 93059004236 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 93059004237 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 93059004238 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 93059004239 30S ribosomal protein S7; Validated; Region: PRK05302 93059004240 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 93059004241 S17 interaction site [polypeptide binding]; other site 93059004242 S8 interaction site; other site 93059004243 16S rRNA interaction site [nucleotide binding]; other site 93059004244 streptomycin interaction site [chemical binding]; other site 93059004245 23S rRNA interaction site [nucleotide binding]; other site 93059004246 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 93059004247 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 93059004248 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 93059004249 active site 93059004250 dimer interface [polypeptide binding]; other site 93059004251 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 93059004252 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 93059004253 active site 93059004254 FMN binding site [chemical binding]; other site 93059004255 substrate binding site [chemical binding]; other site 93059004256 3Fe-4S cluster binding site [ion binding]; other site 93059004257 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 93059004258 domain interface; other site 93059004259 YCII-related domain; Region: YCII; cl00999 93059004260 lipoyl synthase; Provisional; Region: PRK05481 93059004261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059004262 FeS/SAM binding site; other site 93059004263 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 93059004264 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 93059004265 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 93059004266 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 93059004267 active site 93059004268 SAM binding site [chemical binding]; other site 93059004269 homodimer interface [polypeptide binding]; other site 93059004270 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 93059004271 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 93059004272 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 93059004273 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 93059004274 NlpC/P60 family; Region: NLPC_P60; pfam00877 93059004275 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 93059004276 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 93059004277 Ligand binding site; other site 93059004278 Putative Catalytic site; other site 93059004279 DXD motif; other site 93059004280 HEAT repeats; Region: HEAT_2; pfam13646 93059004281 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 93059004282 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 93059004283 alanine racemase; Reviewed; Region: alr; PRK00053 93059004284 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 93059004285 active site 93059004286 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93059004287 dimer interface [polypeptide binding]; other site 93059004288 substrate binding site [chemical binding]; other site 93059004289 catalytic residues [active] 93059004290 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 93059004291 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93059004292 active site 93059004293 peptide chain release factor 1; Validated; Region: prfA; PRK00591 93059004294 This domain is found in peptide chain release factors; Region: PCRF; smart00937 93059004295 RF-1 domain; Region: RF-1; pfam00472 93059004296 ribosomal protein L31; Validated; Region: rpl31; CHL00136 93059004297 ribosomal protein S9; Region: rps9; CHL00079 93059004298 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 93059004299 23S rRNA interface [nucleotide binding]; other site 93059004300 L3 interface [polypeptide binding]; other site 93059004301 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 93059004302 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 93059004303 dimerization interface 3.5A [polypeptide binding]; other site 93059004304 active site 93059004305 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 93059004306 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 93059004307 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 93059004308 alphaNTD homodimer interface [polypeptide binding]; other site 93059004309 alphaNTD - beta interaction site [polypeptide binding]; other site 93059004310 alphaNTD - beta' interaction site [polypeptide binding]; other site 93059004311 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 93059004312 30S ribosomal protein S11; Validated; Region: PRK05309 93059004313 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 93059004314 30S ribosomal protein S13; Region: bact_S13; TIGR03631 93059004315 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 93059004316 adenylate kinase; Provisional; Region: PRK14531 93059004317 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 93059004318 AMP-binding site [chemical binding]; other site 93059004319 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 93059004320 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 93059004321 SecY translocase; Region: SecY; pfam00344 93059004322 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 93059004323 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 93059004324 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 93059004325 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 93059004326 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 93059004327 5S rRNA interface [nucleotide binding]; other site 93059004328 L27 interface [polypeptide binding]; other site 93059004329 23S rRNA interface [nucleotide binding]; other site 93059004330 L5 interface [polypeptide binding]; other site 93059004331 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 93059004332 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93059004333 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93059004334 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 93059004335 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 93059004336 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 93059004337 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 93059004338 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 93059004339 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 93059004340 RNA binding site [nucleotide binding]; other site 93059004341 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 93059004342 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 93059004343 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 93059004344 23S rRNA interface [nucleotide binding]; other site 93059004345 putative translocon interaction site; other site 93059004346 signal recognition particle (SRP54) interaction site; other site 93059004347 L23 interface [polypeptide binding]; other site 93059004348 trigger factor interaction site; other site 93059004349 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 93059004350 23S rRNA interface [nucleotide binding]; other site 93059004351 5S rRNA interface [nucleotide binding]; other site 93059004352 putative antibiotic binding site [chemical binding]; other site 93059004353 L25 interface [polypeptide binding]; other site 93059004354 L27 interface [polypeptide binding]; other site 93059004355 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 93059004356 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 93059004357 G-X-X-G motif; other site 93059004358 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 93059004359 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 93059004360 putative translocon binding site; other site 93059004361 protein-rRNA interface [nucleotide binding]; other site 93059004362 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 93059004363 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 93059004364 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 93059004365 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 93059004366 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 93059004367 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 93059004368 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 93059004369 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 93059004370 recombinase A; Provisional; Region: recA; PRK09354 93059004371 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 93059004372 hexamer interface [polypeptide binding]; other site 93059004373 Walker A motif; other site 93059004374 ATP binding site [chemical binding]; other site 93059004375 Walker B motif; other site 93059004376 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93059004377 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 93059004378 arogenate dehydrogenase; Reviewed; Region: PRK07417 93059004379 prephenate dehydrogenase; Validated; Region: PRK08507 93059004380 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 93059004381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93059004382 Fructosamine kinase; Region: Fructosamin_kin; cl17579 93059004383 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 93059004384 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 93059004385 MPN+ (JAMM) motif; other site 93059004386 Zinc-binding site [ion binding]; other site 93059004387 hypothetical protein; Validated; Region: PRK07411 93059004388 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 93059004389 ATP binding site [chemical binding]; other site 93059004390 substrate interface [chemical binding]; other site 93059004391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93059004392 active site residue [active] 93059004393 hypothetical protein; Validated; Region: PRK07413 93059004394 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 93059004395 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 93059004396 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 93059004397 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 93059004398 Ligand Binding Site [chemical binding]; other site 93059004399 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 93059004400 recF protein; Region: recf; TIGR00611 93059004401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059004402 Walker A/P-loop; other site 93059004403 ATP binding site [chemical binding]; other site 93059004404 Q-loop/lid; other site 93059004405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059004406 ABC transporter signature motif; other site 93059004407 Walker B; other site 93059004408 D-loop; other site 93059004409 H-loop/switch region; other site 93059004410 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 93059004411 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 93059004412 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 93059004413 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 93059004414 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 93059004415 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93059004416 PsaD; Region: PsaD; pfam02531 93059004417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93059004418 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 93059004419 Domain of unknown function DUF59; Region: DUF59; pfam01883 93059004420 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 93059004421 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 93059004422 Walker A motif; other site 93059004423 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 93059004424 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 93059004425 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 93059004426 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 93059004427 catalytic site [active] 93059004428 putative active site [active] 93059004429 putative substrate binding site [chemical binding]; other site 93059004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 93059004431 conserved hypothetical protein; Region: TIGR03492 93059004432 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 93059004433 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 93059004434 dimerization interface [polypeptide binding]; other site 93059004435 putative ATP binding site [chemical binding]; other site 93059004436 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 93059004437 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93059004438 active site 93059004439 nucleotide binding site [chemical binding]; other site 93059004440 HIGH motif; other site 93059004441 KMSKS motif; other site 93059004442 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 93059004443 CMP-binding site; other site 93059004444 The sites determining sugar specificity; other site 93059004445 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 93059004446 Low molecular weight phosphatase family; Region: LMWPc; cd00115 93059004447 active site 93059004448 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249 93059004449 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 93059004450 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 93059004451 heme binding pocket [chemical binding]; other site 93059004452 heme ligand [chemical binding]; other site 93059004453 isocitrate dehydrogenase; Validated; Region: PRK07362 93059004454 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 93059004455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 93059004456 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 93059004457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 93059004458 phosphate binding site [ion binding]; other site 93059004459 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 93059004460 active site 93059004461 catalytic residues [active] 93059004462 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 93059004463 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 93059004464 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 93059004465 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 93059004466 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 93059004467 homodimer interface [polypeptide binding]; other site 93059004468 active site pocket [active] 93059004469 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 93059004470 dimerization interface [polypeptide binding]; other site 93059004471 active site 93059004472 metal binding site [ion binding]; metal-binding site 93059004473 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 93059004474 dsRNA binding site [nucleotide binding]; other site 93059004475 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 93059004476 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 93059004477 RimM N-terminal domain; Region: RimM; pfam01782 93059004478 PRC-barrel domain; Region: PRC; pfam05239 93059004479 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 93059004480 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 93059004481 Substrate binding site; other site 93059004482 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 93059004483 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 93059004484 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 93059004485 glutaminase active site [active] 93059004486 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 93059004487 dimer interface [polypeptide binding]; other site 93059004488 active site 93059004489 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 93059004490 dimer interface [polypeptide binding]; other site 93059004491 active site 93059004492 photosystem I subunit VII; Region: psaC; CHL00065 93059004493 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 93059004494 acyl carrier protein; Provisional; Region: acpP; PRK00982 93059004495 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 93059004496 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 93059004497 dimer interface [polypeptide binding]; other site 93059004498 active site 93059004499 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 93059004500 transketolase; Region: PLN02790 93059004501 TPP-binding site [chemical binding]; other site 93059004502 dimer interface [polypeptide binding]; other site 93059004503 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 93059004504 PYR/PP interface [polypeptide binding]; other site 93059004505 dimer interface [polypeptide binding]; other site 93059004506 TPP binding site [chemical binding]; other site 93059004507 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93059004508 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 93059004509 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 93059004510 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 93059004511 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93059004512 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 93059004513 metal binding site [ion binding]; metal-binding site 93059004514 dimer interface [polypeptide binding]; other site 93059004515 TPR repeat; Region: TPR_11; pfam13414 93059004516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059004517 binding surface 93059004518 TPR motif; other site 93059004519 TPR repeat; Region: TPR_11; pfam13414 93059004520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059004521 TPR repeat; Region: TPR_11; pfam13414 93059004522 binding surface 93059004523 TPR motif; other site 93059004524 Tetratricopeptide repeat; Region: TPR_16; pfam13432 93059004525 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 93059004526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059004527 Walker A motif; other site 93059004528 ATP binding site [chemical binding]; other site 93059004529 Walker B motif; other site 93059004530 arginine finger; other site 93059004531 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 93059004532 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 93059004533 SmpB-tmRNA interface; other site 93059004534 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 93059004535 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 93059004536 dimer interface [polypeptide binding]; other site 93059004537 putative anticodon binding site; other site 93059004538 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 93059004539 motif 1; other site 93059004540 active site 93059004541 motif 2; other site 93059004542 motif 3; other site 93059004543 Ycf27; Reviewed; Region: orf27; CHL00148 93059004544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93059004545 active site 93059004546 phosphorylation site [posttranslational modification] 93059004547 intermolecular recognition site; other site 93059004548 dimerization interface [polypeptide binding]; other site 93059004549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93059004550 DNA binding site [nucleotide binding] 93059004551 rod shape-determining protein MreC; Provisional; Region: PRK13922 93059004552 rod shape-determining protein MreC; Region: MreC; pfam04085 93059004553 rod shape-determining protein MreB; Provisional; Region: PRK13927 93059004554 MreB and similar proteins; Region: MreB_like; cd10225 93059004555 nucleotide binding site [chemical binding]; other site 93059004556 Mg binding site [ion binding]; other site 93059004557 putative protofilament interaction site [polypeptide binding]; other site 93059004558 RodZ interaction site [polypeptide binding]; other site 93059004559 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93059004560 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93059004561 dimer interface [polypeptide binding]; other site 93059004562 ssDNA binding site [nucleotide binding]; other site 93059004563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93059004564 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 93059004565 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93059004566 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 93059004567 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 93059004568 homotetramer interface [polypeptide binding]; other site 93059004569 ligand binding site [chemical binding]; other site 93059004570 catalytic site [active] 93059004571 NAD binding site [chemical binding]; other site 93059004572 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 93059004573 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93059004574 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 93059004575 putative substrate binding site [chemical binding]; other site 93059004576 putative ATP binding site [chemical binding]; other site 93059004577 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 93059004578 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93059004579 minor groove reading motif; other site 93059004580 helix-hairpin-helix signature motif; other site 93059004581 substrate binding pocket [chemical binding]; other site 93059004582 active site 93059004583 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 93059004584 active site 93059004585 8-oxo-dGMP binding site [chemical binding]; other site 93059004586 nudix motif; other site 93059004587 metal binding site [ion binding]; metal-binding site 93059004588 hydrolase, alpha/beta fold family protein; Region: PLN02824 93059004589 Serine hydrolase; Region: Ser_hydrolase; cl17834 93059004590 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93059004591 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93059004592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93059004593 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93059004594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93059004595 DNA binding residues [nucleotide binding] 93059004596 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 93059004597 MgtE intracellular N domain; Region: MgtE_N; smart00924 93059004598 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 93059004599 Divalent cation transporter; Region: MgtE; pfam01769 93059004600 CrcB-like protein; Region: CRCB; pfam02537 93059004601 CrcB-like protein; Region: CRCB; pfam02537 93059004602 Bacterial SH3 domain; Region: SH3_3; cl17532 93059004603 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 93059004604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93059004605 Mg2+ binding site [ion binding]; other site 93059004606 G-X-G motif; other site 93059004607 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 93059004608 anchoring element; other site 93059004609 dimer interface [polypeptide binding]; other site 93059004610 ATP binding site [chemical binding]; other site 93059004611 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 93059004612 active site 93059004613 putative metal-binding site [ion binding]; other site 93059004614 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 93059004615 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 93059004616 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 93059004617 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 93059004618 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 93059004619 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 93059004620 Predicted transcriptional regulators [Transcription]; Region: COG1725 93059004621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93059004622 DNA-binding site [nucleotide binding]; DNA binding site 93059004623 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 93059004624 serine O-acetyltransferase; Region: cysE; TIGR01172 93059004625 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 93059004626 trimer interface [polypeptide binding]; other site 93059004627 active site 93059004628 substrate binding site [chemical binding]; other site 93059004629 CoA binding site [chemical binding]; other site 93059004630 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 93059004631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059004632 ATP binding site [chemical binding]; other site 93059004633 putative Mg++ binding site [ion binding]; other site 93059004634 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 93059004635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93059004636 Coenzyme A binding pocket [chemical binding]; other site 93059004637 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 93059004638 homopentamer interface [polypeptide binding]; other site 93059004639 active site 93059004640 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 93059004641 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 93059004642 MutS domain I; Region: MutS_I; pfam01624 93059004643 MutS domain II; Region: MutS_II; pfam05188 93059004644 MutS domain III; Region: MutS_III; pfam05192 93059004645 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 93059004646 Walker A/P-loop; other site 93059004647 ATP binding site [chemical binding]; other site 93059004648 Q-loop/lid; other site 93059004649 ABC transporter signature motif; other site 93059004650 Walker B; other site 93059004651 D-loop; other site 93059004652 H-loop/switch region; other site 93059004653 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 93059004654 Precorrin-8X methylmutase; Region: CbiC; pfam02570 93059004655 DNA polymerase III subunit delta; Validated; Region: PRK07452 93059004656 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 93059004657 aspartate kinase; Provisional; Region: PRK07431 93059004658 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 93059004659 putative nucleotide binding site [chemical binding]; other site 93059004660 putative catalytic residues [active] 93059004661 putative Mg ion binding site [ion binding]; other site 93059004662 putative aspartate binding site [chemical binding]; other site 93059004663 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 93059004664 putative allosteric regulatory site; other site 93059004665 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 93059004666 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 93059004667 putative allosteric regulatory site; other site 93059004668 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 93059004669 putative allosteric regulatory residue; other site 93059004670 excinuclease ABC subunit B; Provisional; Region: PRK05298 93059004671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93059004672 ATP binding site [chemical binding]; other site 93059004673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93059004674 nucleotide binding region [chemical binding]; other site 93059004675 ATP-binding site [chemical binding]; other site 93059004676 Ultra-violet resistance protein B; Region: UvrB; pfam12344 93059004677 UvrB/uvrC motif; Region: UVR; pfam02151 93059004678 Protein of unknown function (DUF561); Region: DUF561; pfam04481 93059004679 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 93059004680 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 93059004681 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 93059004682 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 93059004683 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 93059004684 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 93059004685 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 93059004686 dihydrodipicolinate synthase; Region: dapA; TIGR00674 93059004687 dimer interface [polypeptide binding]; other site 93059004688 active site 93059004689 catalytic residue [active] 93059004690 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 93059004691 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 93059004692 trigger factor; Provisional; Region: tig; PRK01490 93059004693 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 93059004694 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 93059004695 Clp protease; Region: CLP_protease; pfam00574 93059004696 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93059004697 oligomer interface [polypeptide binding]; other site 93059004698 active site residues [active] 93059004699 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 93059004700 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 93059004701 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 93059004702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059004703 Walker A motif; other site 93059004704 ATP binding site [chemical binding]; other site 93059004705 Walker B motif; other site 93059004706 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 93059004707 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 93059004708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93059004709 Walker A motif; other site 93059004710 ATP binding site [chemical binding]; other site 93059004711 Walker B motif; other site 93059004712 arginine finger; other site 93059004713 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 93059004714 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 93059004715 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 93059004716 DXD motif; other site 93059004717 Stage II sporulation protein; Region: SpoIID; pfam08486 93059004718 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 93059004719 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 93059004720 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 93059004721 23S rRNA binding site [nucleotide binding]; other site 93059004722 L21 binding site [polypeptide binding]; other site 93059004723 L13 binding site [polypeptide binding]; other site 93059004724 TPR repeat; Region: TPR_11; pfam13414 93059004725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93059004726 binding surface 93059004727 TPR motif; other site 93059004728 TPR repeat; Region: TPR_11; pfam13414 93059004729 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 93059004730 ThiS interaction site; other site 93059004731 putative active site [active] 93059004732 tetramer interface [polypeptide binding]; other site 93059004733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93059004734 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93059004735 NAD(P) binding site [chemical binding]; other site 93059004736 active site 93059004737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93059004738 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 93059004739 glycine dehydrogenase; Provisional; Region: PRK05367 93059004740 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 93059004741 tetramer interface [polypeptide binding]; other site 93059004742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004743 catalytic residue [active] 93059004744 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 93059004745 tetramer interface [polypeptide binding]; other site 93059004746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004747 catalytic residue [active] 93059004748 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 93059004749 lipoyl attachment site [posttranslational modification]; other site 93059004750 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 93059004751 Aluminium resistance protein; Region: Alum_res; pfam06838 93059004752 Fatty acid desaturase; Region: FA_desaturase; pfam00487 93059004753 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 93059004754 Di-iron ligands [ion binding]; other site 93059004755 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 93059004756 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 93059004757 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 93059004758 replicative DNA helicase; Region: DnaB; TIGR00665 93059004759 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 93059004760 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 93059004761 Walker A motif; other site 93059004762 ATP binding site [chemical binding]; other site 93059004763 Walker B motif; other site 93059004764 DNA binding loops [nucleotide binding] 93059004765 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 93059004766 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 93059004767 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 93059004768 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 93059004769 Protein of unknown function (DUF98); Region: DUF98; pfam01947 93059004770 SprT-like family; Region: SprT-like; pfam10263 93059004771 SprT homologues; Region: SprT; cl01182 93059004772 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 93059004773 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 93059004774 nucleotide binding pocket [chemical binding]; other site 93059004775 K-X-D-G motif; other site 93059004776 catalytic site [active] 93059004777 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 93059004778 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 93059004779 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 93059004780 Dimer interface [polypeptide binding]; other site 93059004781 Uncharacterized conserved protein [Function unknown]; Region: COG0398 93059004782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93059004783 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 93059004784 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93059004785 active site 93059004786 HIGH motif; other site 93059004787 nucleotide binding site [chemical binding]; other site 93059004788 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93059004789 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 93059004790 active site 93059004791 KMSKS motif; other site 93059004792 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 93059004793 tRNA binding surface [nucleotide binding]; other site 93059004794 anticodon binding site; other site 93059004795 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 93059004796 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 93059004797 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 93059004798 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 93059004799 homodimer interface [polypeptide binding]; other site 93059004800 metal binding site [ion binding]; metal-binding site 93059004801 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 93059004802 homodimer interface [polypeptide binding]; other site 93059004803 active site 93059004804 putative chemical substrate binding site [chemical binding]; other site 93059004805 metal binding site [ion binding]; metal-binding site 93059004806 spermidine synthase; Provisional; Region: PRK00811 93059004807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93059004808 S-adenosylmethionine binding site [chemical binding]; other site 93059004809 agmatinase; Region: agmatinase; TIGR01230 93059004810 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 93059004811 putative active site [active] 93059004812 Mn binding site [ion binding]; other site 93059004813 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 93059004814 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 93059004815 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 93059004816 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 93059004817 dimer interface [polypeptide binding]; other site 93059004818 anticodon binding site; other site 93059004819 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 93059004820 homodimer interface [polypeptide binding]; other site 93059004821 motif 1; other site 93059004822 active site 93059004823 motif 2; other site 93059004824 GAD domain; Region: GAD; pfam02938 93059004825 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 93059004826 active site 93059004827 motif 3; other site 93059004828 CTP synthetase; Validated; Region: pyrG; PRK05380 93059004829 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 93059004830 Catalytic site [active] 93059004831 active site 93059004832 UTP binding site [chemical binding]; other site 93059004833 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 93059004834 active site 93059004835 putative oxyanion hole; other site 93059004836 catalytic triad [active] 93059004837 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 93059004838 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 93059004839 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 93059004840 Ligand Binding Site [chemical binding]; other site 93059004841 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 93059004842 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 93059004843 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93059004844 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 93059004845 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 93059004846 homodimer interface [polypeptide binding]; other site 93059004847 substrate-cofactor binding pocket; other site 93059004848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004849 catalytic residue [active] 93059004850 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 93059004851 diphthine synthase; Region: dph5; TIGR00522 93059004852 active site 93059004853 SAM binding site [chemical binding]; other site 93059004854 homodimer interface [polypeptide binding]; other site 93059004855 hypothetical protein; Provisional; Region: PRK07394 93059004856 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 93059004857 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 93059004858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93059004859 putative substrate translocation pore; other site 93059004860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 93059004861 polyphosphate kinase; Provisional; Region: PRK05443 93059004862 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 93059004863 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 93059004864 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 93059004865 putative domain interface [polypeptide binding]; other site 93059004866 putative active site [active] 93059004867 catalytic site [active] 93059004868 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 93059004869 putative domain interface [polypeptide binding]; other site 93059004870 putative active site [active] 93059004871 catalytic site [active] 93059004872 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93059004873 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93059004874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93059004875 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93059004876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93059004877 DNA binding residues [nucleotide binding] 93059004878 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 93059004879 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 93059004880 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 93059004881 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 93059004882 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 93059004883 substrate binding site [chemical binding]; other site 93059004884 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 93059004885 substrate binding site [chemical binding]; other site 93059004886 ligand binding site [chemical binding]; other site 93059004887 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 93059004888 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 93059004889 Cl- selectivity filter; other site 93059004890 Cl- binding residues [ion binding]; other site 93059004891 pore gating glutamate residue; other site 93059004892 dimer interface [polypeptide binding]; other site 93059004893 H+/Cl- coupling transport residue; other site 93059004894 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 93059004895 B12 binding site [chemical binding]; other site 93059004896 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 93059004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93059004898 FeS/SAM binding site; other site 93059004899 O-Antigen ligase; Region: Wzy_C; pfam04932 93059004900 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 93059004901 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 93059004902 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 93059004903 putative active site [active] 93059004904 putative substrate binding site [chemical binding]; other site 93059004905 putative cosubstrate binding site; other site 93059004906 catalytic site [active] 93059004907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93059004908 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 93059004909 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 93059004910 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 93059004911 nucleotide binding site [chemical binding]; other site 93059004912 NEF interaction site [polypeptide binding]; other site 93059004913 SBD interface [polypeptide binding]; other site 93059004914 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 93059004915 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 93059004916 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 93059004917 shikimate binding site; other site 93059004918 NAD(P) binding site [chemical binding]; other site 93059004919 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 93059004920 argininosuccinate synthase; Provisional; Region: PRK13820 93059004921 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 93059004922 ANP binding site [chemical binding]; other site 93059004923 Substrate Binding Site II [chemical binding]; other site 93059004924 Substrate Binding Site I [chemical binding]; other site 93059004925 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 93059004926 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 93059004927 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 93059004928 Mg++ binding site [ion binding]; other site 93059004929 putative catalytic motif [active] 93059004930 putative substrate binding site [chemical binding]; other site 93059004931 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 93059004932 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 93059004933 putative ADP-binding pocket [chemical binding]; other site 93059004934 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 93059004935 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93059004936 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93059004937 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 93059004938 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 93059004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93059004940 Walker A/P-loop; other site 93059004941 ATP binding site [chemical binding]; other site 93059004942 Q-loop/lid; other site 93059004943 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 93059004944 ABC transporter signature motif; other site 93059004945 Walker B; other site 93059004946 D-loop; other site 93059004947 H-loop/switch region; other site 93059004948 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 93059004949 ABC1 family; Region: ABC1; pfam03109 93059004950 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 93059004951 active site 93059004952 ATP binding site [chemical binding]; other site 93059004953 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 93059004954 threonine synthase; Validated; Region: PRK06260 93059004955 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 93059004956 homodimer interface [polypeptide binding]; other site 93059004957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93059004958 catalytic residue [active]