-- dump date 20140620_000109 -- class Genbank::misc_feature -- table misc_feature_note -- id note 93060000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 93060000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 93060000003 putative DNA binding surface [nucleotide binding]; other site 93060000004 dimer interface [polypeptide binding]; other site 93060000005 beta-clamp/clamp loader binding surface; other site 93060000006 beta-clamp/translesion DNA polymerase binding surface; other site 93060000007 PRC-barrel domain; Region: PRC; pfam05239 93060000008 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 93060000009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 93060000010 dimerization interface [polypeptide binding]; other site 93060000011 ATP binding site [chemical binding]; other site 93060000012 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 93060000013 dimerization interface [polypeptide binding]; other site 93060000014 ATP binding site [chemical binding]; other site 93060000015 amidophosphoribosyltransferase; Provisional; Region: PRK09246 93060000016 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 93060000017 active site 93060000018 tetramer interface [polypeptide binding]; other site 93060000019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060000020 active site 93060000021 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 93060000022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93060000023 CAP-like domain; other site 93060000024 active site 93060000025 primary dimer interface [polypeptide binding]; other site 93060000026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060000027 TPR motif; other site 93060000028 TPR repeat; Region: TPR_11; pfam13414 93060000029 binding surface 93060000030 TPR repeat; Region: TPR_11; pfam13414 93060000031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060000032 binding surface 93060000033 TPR motif; other site 93060000034 TPR repeat; Region: TPR_11; pfam13414 93060000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 93060000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 93060000037 Uncharacterized conserved protein [Function unknown]; Region: COG2928 93060000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 93060000039 putative RNA binding site [nucleotide binding]; other site 93060000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 93060000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 93060000042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060000043 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 93060000044 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 93060000045 argininosuccinate lyase; Provisional; Region: PRK00855 93060000046 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 93060000047 active sites [active] 93060000048 tetramer interface [polypeptide binding]; other site 93060000049 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 93060000050 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93060000051 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 93060000052 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 93060000053 FMN binding site [chemical binding]; other site 93060000054 active site 93060000055 catalytic residues [active] 93060000056 substrate binding site [chemical binding]; other site 93060000057 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 93060000058 SelR domain; Region: SelR; pfam01641 93060000059 GrpE; Region: GrpE; pfam01025 93060000060 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 93060000061 dimer interface [polypeptide binding]; other site 93060000062 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 93060000063 chaperone protein DnaJ; Provisional; Region: PRK14293 93060000064 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93060000065 HSP70 interaction site [polypeptide binding]; other site 93060000066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 93060000067 substrate binding site [polypeptide binding]; other site 93060000068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 93060000069 Zn binding sites [ion binding]; other site 93060000070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93060000071 dimer interface [polypeptide binding]; other site 93060000072 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 93060000073 CPxP motif; other site 93060000074 Predicted GTPases [General function prediction only]; Region: COG1162 93060000075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 93060000076 RNA binding site [nucleotide binding]; other site 93060000077 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 93060000078 GTPase/Zn-binding domain interface [polypeptide binding]; other site 93060000079 GTP/Mg2+ binding site [chemical binding]; other site 93060000080 G4 box; other site 93060000081 G5 box; other site 93060000082 G1 box; other site 93060000083 Switch I region; other site 93060000084 G2 box; other site 93060000085 G3 box; other site 93060000086 Switch II region; other site 93060000087 hypothetical protein; Validated; Region: PRK00153 93060000088 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 93060000089 FAD binding domain; Region: FAD_binding_4; pfam01565 93060000090 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 93060000091 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 93060000092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93060000093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93060000094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93060000095 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 93060000096 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 93060000097 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 93060000098 thiamine monophosphate kinase; Provisional; Region: PRK05731 93060000099 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 93060000100 ATP binding site [chemical binding]; other site 93060000101 dimerization interface [polypeptide binding]; other site 93060000102 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 93060000103 active site 93060000104 elongation factor P; Validated; Region: PRK00529 93060000105 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 93060000106 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 93060000107 RNA binding site [nucleotide binding]; other site 93060000108 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 93060000109 RNA binding site [nucleotide binding]; other site 93060000110 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 93060000111 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 93060000112 carboxyltransferase (CT) interaction site; other site 93060000113 biotinylation site [posttranslational modification]; other site 93060000114 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 93060000115 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 93060000116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060000117 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 93060000118 putative NAD(P) binding site [chemical binding]; other site 93060000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93060000120 active site 93060000121 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 93060000122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 93060000123 homodimer interface [polypeptide binding]; other site 93060000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000125 catalytic residue [active] 93060000126 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 93060000127 GMP synthase; Reviewed; Region: guaA; PRK00074 93060000128 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 93060000129 AMP/PPi binding site [chemical binding]; other site 93060000130 candidate oxyanion hole; other site 93060000131 catalytic triad [active] 93060000132 potential glutamine specificity residues [chemical binding]; other site 93060000133 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 93060000134 ATP Binding subdomain [chemical binding]; other site 93060000135 Ligand Binding sites [chemical binding]; other site 93060000136 Dimerization subdomain; other site 93060000137 rod shape-determining protein MreB; Provisional; Region: PRK13927 93060000138 MreB and similar proteins; Region: MreB_like; cd10225 93060000139 nucleotide binding site [chemical binding]; other site 93060000140 Mg binding site [ion binding]; other site 93060000141 putative protofilament interaction site [polypeptide binding]; other site 93060000142 RodZ interaction site [polypeptide binding]; other site 93060000143 Domain of unknown function (DUF316); Region: DUF316; pfam03761 93060000144 Domain of unknown function (DUF368); Region: DUF368; cl00893 93060000145 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 93060000146 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 93060000147 hinge; other site 93060000148 active site 93060000149 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 93060000150 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 93060000151 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 93060000152 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 93060000153 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 93060000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93060000155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 93060000156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 93060000157 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 93060000158 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 93060000159 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 93060000160 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 93060000161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93060000162 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 93060000163 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 93060000164 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 93060000165 motif 1; other site 93060000166 active site 93060000167 motif 2; other site 93060000168 motif 3; other site 93060000169 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 93060000170 DHHA1 domain; Region: DHHA1; pfam02272 93060000171 arginine decarboxylase; Provisional; Region: PRK05354 93060000172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 93060000173 dimer interface [polypeptide binding]; other site 93060000174 active site 93060000175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93060000176 catalytic residues [active] 93060000177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 93060000178 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 93060000179 active site 93060000180 multimer interface [polypeptide binding]; other site 93060000181 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 93060000182 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 93060000183 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 93060000184 GatB domain; Region: GatB_Yqey; smart00845 93060000185 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 93060000186 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 93060000187 CoA-binding site [chemical binding]; other site 93060000188 ATP-binding [chemical binding]; other site 93060000189 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 93060000190 heterotetramer interface [polypeptide binding]; other site 93060000191 active site pocket [active] 93060000192 cleavage site 93060000193 ParA-like protein; Provisional; Region: PHA02518 93060000194 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 93060000195 P-loop; other site 93060000196 Magnesium ion binding site [ion binding]; other site 93060000197 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 93060000198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93060000199 active site 93060000200 catalytic tetrad [active] 93060000201 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 93060000202 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 93060000203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060000204 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 93060000205 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 93060000206 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 93060000207 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93060000208 Walker A/P-loop; other site 93060000209 ATP binding site [chemical binding]; other site 93060000210 Q-loop/lid; other site 93060000211 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 93060000212 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 93060000213 ABC transporter signature motif; other site 93060000214 Walker B; other site 93060000215 D-loop; other site 93060000216 H-loop/switch region; other site 93060000217 PRC-barrel domain; Region: PRC; pfam05239 93060000218 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 93060000219 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 93060000220 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93060000221 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93060000222 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 93060000223 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 93060000224 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 93060000225 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 93060000226 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 93060000227 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 93060000228 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 93060000229 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 93060000230 nucleotide binding site/active site [active] 93060000231 HIT family signature motif; other site 93060000232 catalytic residue [active] 93060000233 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 93060000234 active site 93060000235 catalytic residues [active] 93060000236 metal binding site [ion binding]; metal-binding site 93060000237 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 93060000238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 93060000239 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 93060000240 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 93060000241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060000242 catalytic residue [active] 93060000243 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 93060000244 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 93060000245 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 93060000246 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 93060000247 Walker A/P-loop; other site 93060000248 ATP binding site [chemical binding]; other site 93060000249 Q-loop/lid; other site 93060000250 ABC transporter signature motif; other site 93060000251 Walker B; other site 93060000252 D-loop; other site 93060000253 H-loop/switch region; other site 93060000254 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 93060000255 putative ABC transporter; Region: ycf24; CHL00085 93060000256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 93060000257 phosphoglucomutase; Region: PLN02307 93060000258 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 93060000259 active site 93060000260 substrate binding site [chemical binding]; other site 93060000261 metal binding site [ion binding]; metal-binding site 93060000262 recombination factor protein RarA; Reviewed; Region: PRK13342 93060000263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060000264 Walker A motif; other site 93060000265 ATP binding site [chemical binding]; other site 93060000266 Walker B motif; other site 93060000267 arginine finger; other site 93060000268 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 93060000269 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 93060000270 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93060000271 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93060000272 catalytic triad [active] 93060000273 Type III pantothenate kinase; Region: Pan_kinase; cl17198 93060000274 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 93060000275 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 93060000276 Active Sites [active] 93060000277 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 93060000278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93060000279 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93060000280 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93060000281 transmembrane helices; other site 93060000282 TrkA-C domain; Region: TrkA_C; pfam02080 93060000283 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 93060000284 TrkA-C domain; Region: TrkA_C; pfam02080 93060000285 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 93060000286 Cation transport protein; Region: TrkH; cl17365 93060000287 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 93060000288 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 93060000289 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93060000290 TrkA-N domain; Region: TrkA_N; pfam02254 93060000291 TrkA-C domain; Region: TrkA_C; pfam02080 93060000292 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 93060000293 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 93060000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060000295 Walker A/P-loop; other site 93060000296 ATP binding site [chemical binding]; other site 93060000297 Q-loop/lid; other site 93060000298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93060000299 ABC transporter signature motif; other site 93060000300 Walker B; other site 93060000301 D-loop; other site 93060000302 ABC transporter; Region: ABC_tran_2; pfam12848 93060000303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 93060000304 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93060000305 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93060000306 protein binding site [polypeptide binding]; other site 93060000307 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 93060000308 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08579 93060000309 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 93060000310 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 93060000311 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 93060000312 active site 93060000313 Outer membrane efflux protein; Region: OEP; pfam02321 93060000314 Outer membrane efflux protein; Region: OEP; pfam02321 93060000315 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 93060000316 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 93060000317 Protein of unknown function (DUF512); Region: DUF512; pfam04459 93060000318 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 93060000319 L-aspartate oxidase; Provisional; Region: PRK07395 93060000320 L-aspartate oxidase; Provisional; Region: PRK06175 93060000321 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 93060000322 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 93060000323 substrate binding site [chemical binding]; other site 93060000324 putative active site [active] 93060000325 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 93060000326 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 93060000327 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93060000328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060000329 FeS/SAM binding site; other site 93060000330 TRAM domain; Region: TRAM; cl01282 93060000331 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 93060000332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 93060000333 Protein of unknown function, DUF482; Region: DUF482; pfam04339 93060000334 RibD C-terminal domain; Region: RibD_C; cl17279 93060000335 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93060000336 active site 93060000337 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93060000338 active site 93060000339 shikimate kinase; Reviewed; Region: aroK; PRK00131 93060000340 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 93060000341 ADP binding site [chemical binding]; other site 93060000342 magnesium binding site [ion binding]; other site 93060000343 putative shikimate binding site; other site 93060000344 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 93060000345 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93060000346 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 93060000347 C-terminal domain interface [polypeptide binding]; other site 93060000348 GSH binding site (G-site) [chemical binding]; other site 93060000349 dimer interface [polypeptide binding]; other site 93060000350 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 93060000351 N-terminal domain interface [polypeptide binding]; other site 93060000352 dimer interface [polypeptide binding]; other site 93060000353 substrate binding pocket (H-site) [chemical binding]; other site 93060000354 Protein of unknown function (DUF751); Region: DUF751; pfam05421 93060000355 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 93060000356 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 93060000357 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 93060000358 active site 93060000359 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 93060000360 putative hydrophobic ligand binding site [chemical binding]; other site 93060000361 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 93060000362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060000363 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 93060000364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060000365 TPR motif; other site 93060000366 binding surface 93060000367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 93060000368 conserved hypothetical protein; Region: TIGR03492 93060000369 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 93060000370 TIGR01777 family protein; Region: yfcH 93060000371 putative NAD(P) binding site [chemical binding]; other site 93060000372 putative active site [active] 93060000373 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 93060000374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93060000375 HSP70 interaction site [polypeptide binding]; other site 93060000376 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 93060000377 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93060000378 dimer interface [polypeptide binding]; other site 93060000379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000380 catalytic residue [active] 93060000381 hypothetical protein; Provisional; Region: PRK13683 93060000382 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93060000383 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93060000384 Walker A/P-loop; other site 93060000385 ATP binding site [chemical binding]; other site 93060000386 Q-loop/lid; other site 93060000387 ABC transporter signature motif; other site 93060000388 Walker B; other site 93060000389 D-loop; other site 93060000390 H-loop/switch region; other site 93060000391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93060000392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93060000393 active site 93060000394 phosphorylation site [posttranslational modification] 93060000395 intermolecular recognition site; other site 93060000396 dimerization interface [polypeptide binding]; other site 93060000397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93060000398 DNA binding site [nucleotide binding] 93060000399 DNA polymerase III subunit delta'; Validated; Region: PRK07399 93060000400 DNA polymerase III subunit delta'; Validated; Region: PRK08485 93060000401 thymidylate kinase; Validated; Region: tmk; PRK00698 93060000402 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 93060000403 TMP-binding site; other site 93060000404 ATP-binding site [chemical binding]; other site 93060000405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 93060000406 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 93060000407 metal-binding site [ion binding] 93060000408 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 93060000409 Soluble P-type ATPase [General function prediction only]; Region: COG4087 93060000410 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 93060000411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060000412 binding surface 93060000413 TPR motif; other site 93060000414 DNA repair protein RadA; Provisional; Region: PRK11823 93060000415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93060000416 Walker A motif; other site 93060000417 ATP binding site [chemical binding]; other site 93060000418 Walker B motif; other site 93060000419 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 93060000420 Ycf27; Reviewed; Region: orf27; CHL00148 93060000421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93060000422 active site 93060000423 phosphorylation site [posttranslational modification] 93060000424 intermolecular recognition site; other site 93060000425 dimerization interface [polypeptide binding]; other site 93060000426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93060000427 DNA binding site [nucleotide binding] 93060000428 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 93060000429 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 93060000430 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 93060000431 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 93060000432 dimer interface [polypeptide binding]; other site 93060000433 active site 93060000434 CoA binding pocket [chemical binding]; other site 93060000435 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 93060000436 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 93060000437 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 93060000438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 93060000439 putative acyl-acceptor binding pocket; other site 93060000440 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 93060000441 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 93060000442 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 93060000443 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 93060000444 active site 93060000445 NTP binding site [chemical binding]; other site 93060000446 metal binding triad [ion binding]; metal-binding site 93060000447 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 93060000448 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93060000449 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 93060000450 active site lid residues [active] 93060000451 substrate binding pocket [chemical binding]; other site 93060000452 catalytic residues [active] 93060000453 substrate-Mg2+ binding site; other site 93060000454 aspartate-rich region 1; other site 93060000455 aspartate-rich region 2; other site 93060000456 phytoene desaturase; Region: phytoene_desat; TIGR02731 93060000457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060000458 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 93060000459 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 93060000460 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 93060000461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 93060000462 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 93060000463 putative dimerization interface [polypeptide binding]; other site 93060000464 NnrU protein; Region: NnrU; cl17713 93060000465 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 93060000466 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 93060000467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93060000468 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 93060000469 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 93060000470 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93060000471 ScpA/B protein; Region: ScpA_ScpB; cl00598 93060000472 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93060000473 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 93060000474 active site 93060000475 Substrate binding site; other site 93060000476 Mg++ binding site; other site 93060000477 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 93060000478 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 93060000479 FAD binding site [chemical binding]; other site 93060000480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93060000481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93060000482 DNA binding residues [nucleotide binding] 93060000483 dimerization interface [polypeptide binding]; other site 93060000484 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 93060000485 putative active site [active] 93060000486 putative metal binding residues [ion binding]; other site 93060000487 signature motif; other site 93060000488 putative dimer interface [polypeptide binding]; other site 93060000489 putative phosphate binding site [ion binding]; other site 93060000490 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 93060000491 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 93060000492 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 93060000493 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 93060000494 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 93060000495 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 93060000496 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 93060000497 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 93060000498 NADH dehydrogenase; Region: NADHdh; cl00469 93060000499 citrate synthase; Provisional; Region: PRK14036 93060000500 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 93060000501 oxalacetate binding site [chemical binding]; other site 93060000502 citrylCoA binding site [chemical binding]; other site 93060000503 coenzyme A binding site [chemical binding]; other site 93060000504 catalytic triad [active] 93060000505 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 93060000506 active site residue [active] 93060000507 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 93060000508 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 93060000509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000510 catalytic residue [active] 93060000511 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 93060000512 putative rRNA binding site [nucleotide binding]; other site 93060000513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060000514 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 93060000515 Walker A/P-loop; other site 93060000516 ligand-binding site [chemical binding]; other site 93060000517 ATP binding site [chemical binding]; other site 93060000518 AIR carboxylase; Region: AIRC; pfam00731 93060000519 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 93060000520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060000521 S-adenosylmethionine binding site [chemical binding]; other site 93060000522 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 93060000523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 93060000524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93060000525 active site 93060000526 phosphorylation site [posttranslational modification] 93060000527 intermolecular recognition site; other site 93060000528 dimerization interface [polypeptide binding]; other site 93060000529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 93060000530 DNA binding residues [nucleotide binding] 93060000531 dimerization interface [polypeptide binding]; other site 93060000532 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 93060000533 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 93060000534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060000535 catalytic residue [active] 93060000536 MraW methylase family; Region: Methyltransf_5; cl17771 93060000537 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 93060000538 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 93060000539 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 93060000540 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93060000541 active site 93060000542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93060000543 acyl-activating enzyme (AAE) consensus motif; other site 93060000544 active site 93060000545 AMP binding site [chemical binding]; other site 93060000546 CoA binding site [chemical binding]; other site 93060000547 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 93060000548 active site 93060000549 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 93060000550 UbiA prenyltransferase family; Region: UbiA; pfam01040 93060000551 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93060000552 glutathione synthetase; Provisional; Region: PRK05246 93060000553 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 93060000554 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 93060000555 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 93060000556 GSH binding site [chemical binding]; other site 93060000557 catalytic residues [active] 93060000558 peptide chain release factor 2; Validated; Region: prfB; PRK00578 93060000559 PCRF domain; Region: PCRF; pfam03462 93060000560 RF-1 domain; Region: RF-1; pfam00472 93060000561 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 93060000562 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 93060000563 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 93060000564 Glutamine amidotransferase class-I; Region: GATase; pfam00117 93060000565 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 93060000566 glutamine binding [chemical binding]; other site 93060000567 catalytic triad [active] 93060000568 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 93060000569 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 93060000570 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 93060000571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93060000572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000573 homodimer interface [polypeptide binding]; other site 93060000574 catalytic residue [active] 93060000575 arginine-tRNA ligase; Region: PLN02286 93060000576 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 93060000577 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 93060000578 active site 93060000579 HIGH motif; other site 93060000580 KMSK motif region; other site 93060000581 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 93060000582 tRNA binding surface [nucleotide binding]; other site 93060000583 anticodon binding site; other site 93060000584 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 93060000585 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 93060000586 dimerization interface [polypeptide binding]; other site 93060000587 active site 93060000588 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 93060000589 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 93060000590 trmE is a tRNA modification GTPase; Region: trmE; cd04164 93060000591 G1 box; other site 93060000592 GTP/Mg2+ binding site [chemical binding]; other site 93060000593 Switch I region; other site 93060000594 G2 box; other site 93060000595 Switch II region; other site 93060000596 G3 box; other site 93060000597 G4 box; other site 93060000598 G5 box; other site 93060000599 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 93060000600 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 93060000601 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 93060000602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93060000603 Zn2+ binding site [ion binding]; other site 93060000604 Mg2+ binding site [ion binding]; other site 93060000605 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 93060000606 synthetase active site [active] 93060000607 NTP binding site [chemical binding]; other site 93060000608 metal binding site [ion binding]; metal-binding site 93060000609 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 93060000610 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 93060000611 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 93060000612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93060000613 Walker A/P-loop; other site 93060000614 ATP binding site [chemical binding]; other site 93060000615 Q-loop/lid; other site 93060000616 ABC transporter signature motif; other site 93060000617 Walker B; other site 93060000618 D-loop; other site 93060000619 H-loop/switch region; other site 93060000620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 93060000621 Walker A/P-loop; other site 93060000622 ATP binding site [chemical binding]; other site 93060000623 Q-loop/lid; other site 93060000624 ABC transporter signature motif; other site 93060000625 Walker B; other site 93060000626 D-loop; other site 93060000627 H-loop/switch region; other site 93060000628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 93060000629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93060000630 RNA binding surface [nucleotide binding]; other site 93060000631 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 93060000632 active site 93060000633 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 93060000634 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 93060000635 GTP/Mg2+ binding site [chemical binding]; other site 93060000636 G4 box; other site 93060000637 G5 box; other site 93060000638 G1 box; other site 93060000639 Switch I region; other site 93060000640 G2 box; other site 93060000641 G3 box; other site 93060000642 Switch II region; other site 93060000643 Phosphoglycerate kinase; Region: PGK; pfam00162 93060000644 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 93060000645 substrate binding site [chemical binding]; other site 93060000646 hinge regions; other site 93060000647 ADP binding site [chemical binding]; other site 93060000648 catalytic site [active] 93060000649 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 93060000650 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 93060000651 active site 93060000652 homodimer interface [polypeptide binding]; other site 93060000653 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 93060000654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93060000655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000656 homodimer interface [polypeptide binding]; other site 93060000657 catalytic residue [active] 93060000658 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 93060000659 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 93060000660 active site 93060000661 catalytic residues [active] 93060000662 FMN binding site [chemical binding]; other site 93060000663 quinone interaction residues [chemical binding]; other site 93060000664 substrate binding site [chemical binding]; other site 93060000665 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 93060000666 RNA/DNA hybrid binding site [nucleotide binding]; other site 93060000667 active site 93060000668 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 93060000669 L11 interface [polypeptide binding]; other site 93060000670 putative EF-Tu interaction site [polypeptide binding]; other site 93060000671 putative EF-G interaction site [polypeptide binding]; other site 93060000672 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 93060000673 23S rRNA interface [nucleotide binding]; other site 93060000674 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 93060000675 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 93060000676 mRNA/rRNA interface [nucleotide binding]; other site 93060000677 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 93060000678 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 93060000679 23S rRNA interface [nucleotide binding]; other site 93060000680 L7/L12 interface [polypeptide binding]; other site 93060000681 putative thiostrepton binding site; other site 93060000682 L25 interface [polypeptide binding]; other site 93060000683 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 93060000684 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 93060000685 putative homodimer interface [polypeptide binding]; other site 93060000686 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 93060000687 heterodimer interface [polypeptide binding]; other site 93060000688 homodimer interface [polypeptide binding]; other site 93060000689 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 93060000690 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 93060000691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060000692 Walker A motif; other site 93060000693 ATP binding site [chemical binding]; other site 93060000694 Walker B motif; other site 93060000695 arginine finger; other site 93060000696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060000697 Walker A motif; other site 93060000698 ATP binding site [chemical binding]; other site 93060000699 Walker B motif; other site 93060000700 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93060000701 enolase; Provisional; Region: eno; PRK00077 93060000702 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 93060000703 dimer interface [polypeptide binding]; other site 93060000704 metal binding site [ion binding]; metal-binding site 93060000705 substrate binding pocket [chemical binding]; other site 93060000706 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 93060000707 ABC1 family; Region: ABC1; pfam03109 93060000708 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 93060000709 active site 93060000710 ATP binding site [chemical binding]; other site 93060000711 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 93060000712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93060000713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93060000714 Nitrogen regulatory protein P-II; Region: P-II; cl00412 93060000715 Domain of unknown function (DUF897); Region: DUF897; pfam05982 93060000716 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 93060000717 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 93060000718 Sulfate transporter family; Region: Sulfate_transp; pfam00916 93060000719 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 93060000720 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 93060000721 dimer interface [polypeptide binding]; other site 93060000722 allosteric magnesium binding site [ion binding]; other site 93060000723 active site 93060000724 aspartate-rich active site metal binding site; other site 93060000725 Schiff base residues; other site 93060000726 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 93060000727 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 93060000728 active site 93060000729 metal binding site [ion binding]; metal-binding site 93060000730 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 93060000731 MutS domain III; Region: MutS_III; pfam05192 93060000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060000733 Walker A/P-loop; other site 93060000734 ATP binding site [chemical binding]; other site 93060000735 Q-loop/lid; other site 93060000736 ABC transporter signature motif; other site 93060000737 Walker B; other site 93060000738 D-loop; other site 93060000739 H-loop/switch region; other site 93060000740 Smr domain; Region: Smr; pfam01713 93060000741 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 93060000742 GTP1/OBG; Region: GTP1_OBG; pfam01018 93060000743 Obg GTPase; Region: Obg; cd01898 93060000744 G1 box; other site 93060000745 GTP/Mg2+ binding site [chemical binding]; other site 93060000746 Switch I region; other site 93060000747 G2 box; other site 93060000748 G3 box; other site 93060000749 Switch II region; other site 93060000750 G4 box; other site 93060000751 CP12 domain; Region: CP12; pfam02672 93060000752 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 93060000753 putative dimer interface [polypeptide binding]; other site 93060000754 N-terminal domain interface [polypeptide binding]; other site 93060000755 putative substrate binding pocket (H-site) [chemical binding]; other site 93060000756 aspartoacylase; Provisional; Region: PRK02259 93060000757 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 93060000758 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 93060000759 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 93060000760 Tetramer interface [polypeptide binding]; other site 93060000761 active site 93060000762 FMN-binding site [chemical binding]; other site 93060000763 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 93060000764 active site 93060000765 intersubunit interface [polypeptide binding]; other site 93060000766 catalytic residue [active] 93060000767 FtsH Extracellular; Region: FtsH_ext; pfam06480 93060000768 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 93060000769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060000770 Walker A motif; other site 93060000771 ATP binding site [chemical binding]; other site 93060000772 Walker B motif; other site 93060000773 arginine finger; other site 93060000774 Peptidase family M41; Region: Peptidase_M41; pfam01434 93060000775 ATP sulphurylase; Region: sopT; TIGR00339 93060000776 ATP-sulfurylase; Region: ATPS; cd00517 93060000777 active site 93060000778 HXXH motif; other site 93060000779 flexible loop; other site 93060000780 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 93060000781 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 93060000782 Flavoprotein; Region: Flavoprotein; pfam02441 93060000783 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 93060000784 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 93060000785 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 93060000786 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93060000787 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93060000788 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 93060000789 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 93060000790 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 93060000791 putative di-iron ligands [ion binding]; other site 93060000792 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 93060000793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060000794 active site 93060000795 HIGH motif; other site 93060000796 nucleotide binding site [chemical binding]; other site 93060000797 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93060000798 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 93060000799 active site 93060000800 KMSKS motif; other site 93060000801 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 93060000802 tRNA binding surface [nucleotide binding]; other site 93060000803 anticodon binding site; other site 93060000804 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 93060000805 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 93060000806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060000807 S-adenosylmethionine binding site [chemical binding]; other site 93060000808 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 93060000809 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 93060000810 active site 93060000811 substrate binding site [chemical binding]; other site 93060000812 metal binding site [ion binding]; metal-binding site 93060000813 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93060000814 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 93060000815 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 93060000816 trimer interface [polypeptide binding]; other site 93060000817 active site 93060000818 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 93060000819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 93060000820 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 93060000821 ligand binding site [chemical binding]; other site 93060000822 flexible hinge region; other site 93060000823 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 93060000824 putative switch regulator; other site 93060000825 non-specific DNA interactions [nucleotide binding]; other site 93060000826 DNA binding site [nucleotide binding] 93060000827 sequence specific DNA binding site [nucleotide binding]; other site 93060000828 putative cAMP binding site [chemical binding]; other site 93060000829 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 93060000830 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 93060000831 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 93060000832 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 93060000833 putative active site [active] 93060000834 catalytic residue [active] 93060000835 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 93060000836 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 93060000837 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 93060000838 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 93060000839 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 93060000840 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 93060000841 hypothetical protein; Provisional; Region: PRK14812 93060000842 substrate binding site [chemical binding]; other site 93060000843 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 93060000844 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 93060000845 substrate binding site [chemical binding]; other site 93060000846 ligand binding site [chemical binding]; other site 93060000847 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 93060000848 competence damage-inducible protein A; Provisional; Region: PRK00549 93060000849 putative MPT binding site; other site 93060000850 Competence-damaged protein; Region: CinA; pfam02464 93060000851 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 93060000852 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 93060000853 dimer interface [polypeptide binding]; other site 93060000854 active site 93060000855 glycine-pyridoxal phosphate binding site [chemical binding]; other site 93060000856 folate binding site [chemical binding]; other site 93060000857 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 93060000858 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 93060000859 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 93060000860 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 93060000861 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 93060000862 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 93060000863 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 93060000864 DoxX; Region: DoxX; pfam07681 93060000865 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 93060000866 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 93060000867 purine monophosphate binding site [chemical binding]; other site 93060000868 dimer interface [polypeptide binding]; other site 93060000869 putative catalytic residues [active] 93060000870 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 93060000871 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 93060000872 Predicted esterase [General function prediction only]; Region: COG0400 93060000873 Serine hydrolase (FSH1); Region: FSH1; pfam03959 93060000874 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 93060000875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93060000876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93060000877 phosphorylation site [posttranslational modification] 93060000878 dimer interface [polypeptide binding]; other site 93060000879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93060000880 ATP binding site [chemical binding]; other site 93060000881 Mg2+ binding site [ion binding]; other site 93060000882 G-X-G motif; other site 93060000883 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 93060000884 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 93060000885 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 93060000886 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 93060000887 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93060000888 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93060000889 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 93060000890 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 93060000891 Domain of unknown function DUF21; Region: DUF21; pfam01595 93060000892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93060000893 Transporter associated domain; Region: CorC_HlyC; smart01091 93060000894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060000895 active site 93060000896 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 93060000897 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 93060000898 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 93060000899 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 93060000900 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 93060000901 RNase_H superfamily; Region: RNase_H_2; pfam13482 93060000902 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 93060000903 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 93060000904 active site 93060000905 substrate binding site [chemical binding]; other site 93060000906 metal binding site [ion binding]; metal-binding site 93060000907 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 93060000908 active site 93060000909 dimerization interface [polypeptide binding]; other site 93060000910 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 93060000911 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 93060000912 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 93060000913 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 93060000914 putative active site pocket [active] 93060000915 4-fold oligomerization interface [polypeptide binding]; other site 93060000916 metal binding residues [ion binding]; metal-binding site 93060000917 3-fold/trimer interface [polypeptide binding]; other site 93060000918 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 93060000919 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 93060000920 NAD binding site [chemical binding]; other site 93060000921 homotetramer interface [polypeptide binding]; other site 93060000922 homodimer interface [polypeptide binding]; other site 93060000923 substrate binding site [chemical binding]; other site 93060000924 active site 93060000925 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 93060000926 putative catalytic residue [active] 93060000927 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 93060000928 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 93060000929 inhibitor-cofactor binding pocket; inhibition site 93060000930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060000931 catalytic residue [active] 93060000932 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 93060000933 DNA photolyase; Region: DNA_photolyase; pfam00875 93060000934 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 93060000935 dimer interface [polypeptide binding]; other site 93060000936 ADP-ribose binding site [chemical binding]; other site 93060000937 active site 93060000938 nudix motif; other site 93060000939 metal binding site [ion binding]; metal-binding site 93060000940 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 93060000941 catalytic center binding site [active] 93060000942 ATP binding site [chemical binding]; other site 93060000943 Protein of unknown function (DUF444); Region: DUF444; cl17371 93060000944 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 93060000945 metal ion-dependent adhesion site (MIDAS); other site 93060000946 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 93060000947 mce related protein; Region: MCE; pfam02470 93060000948 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 93060000949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060000950 Walker A/P-loop; other site 93060000951 ATP binding site [chemical binding]; other site 93060000952 Q-loop/lid; other site 93060000953 ABC transporter signature motif; other site 93060000954 Walker B; other site 93060000955 D-loop; other site 93060000956 H-loop/switch region; other site 93060000957 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 93060000958 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 93060000959 phosphate binding site [ion binding]; other site 93060000960 putative substrate binding pocket [chemical binding]; other site 93060000961 dimer interface [polypeptide binding]; other site 93060000962 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 93060000963 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 93060000964 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 93060000965 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 93060000966 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 93060000967 Rubredoxin; Region: Rubredoxin; pfam00301 93060000968 iron binding site [ion binding]; other site 93060000969 Ycf48-like protein; Provisional; Region: PRK13684 93060000970 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 93060000971 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 93060000972 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 93060000973 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 93060000974 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 93060000975 photosystem II reaction center protein J; Provisional; Region: PRK02565 93060000976 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 93060000977 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 93060000978 selenium donor protein; Region: selD; TIGR00476 93060000979 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 93060000980 dimerization interface [polypeptide binding]; other site 93060000981 ATP binding site [chemical binding]; other site 93060000982 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 93060000983 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 93060000984 active site 93060000985 NTP binding site [chemical binding]; other site 93060000986 metal binding triad [ion binding]; metal-binding site 93060000987 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 93060000988 Part of AAA domain; Region: AAA_19; pfam13245 93060000989 Family description; Region: UvrD_C_2; pfam13538 93060000990 Phycobilisome protein; Region: Phycobilisome; cl08227 93060000991 CpeS-like protein; Region: CpeS; pfam09367 93060000992 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 93060000993 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93060000994 D-xylulose kinase; Region: XylB; TIGR01312 93060000995 nucleotide binding site [chemical binding]; other site 93060000996 S-adenosylmethionine synthetase; Validated; Region: PRK05250 93060000997 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 93060000998 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 93060000999 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 93060001000 30S ribosomal protein S1; Reviewed; Region: PRK07400 93060001001 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 93060001002 RNA binding site [nucleotide binding]; other site 93060001003 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 93060001004 RNA binding site [nucleotide binding]; other site 93060001005 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 93060001006 RNA binding site [nucleotide binding]; other site 93060001007 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 93060001008 ATP cone domain; Region: ATP-cone; pfam03477 93060001009 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 93060001010 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 93060001011 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93060001012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93060001013 catalytic loop [active] 93060001014 iron binding site [ion binding]; other site 93060001015 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 93060001016 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 93060001017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060001018 S-adenosylmethionine binding site [chemical binding]; other site 93060001019 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 93060001020 cell division topological specificity factor MinE; Provisional; Region: PRK13988 93060001021 septum site-determining protein MinD; Region: minD_bact; TIGR01968 93060001022 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 93060001023 P-loop; other site 93060001024 ADP binding residues [chemical binding]; other site 93060001025 Switch I; other site 93060001026 Switch II; other site 93060001027 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 93060001028 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 93060001029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93060001030 Zn2+ binding site [ion binding]; other site 93060001031 Mg2+ binding site [ion binding]; other site 93060001032 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 93060001033 C-terminal peptidase (prc); Region: prc; TIGR00225 93060001034 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93060001035 protein binding site [polypeptide binding]; other site 93060001036 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 93060001037 Catalytic dyad [active] 93060001038 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 93060001039 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 93060001040 Qi binding site; other site 93060001041 intrachain domain interface; other site 93060001042 interchain domain interface [polypeptide binding]; other site 93060001043 heme bH binding site [chemical binding]; other site 93060001044 heme bL binding site [chemical binding]; other site 93060001045 Qo binding site; other site 93060001046 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 93060001047 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 93060001048 interchain domain interface [polypeptide binding]; other site 93060001049 intrachain domain interface; other site 93060001050 Qi binding site; other site 93060001051 Qo binding site; other site 93060001052 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 93060001053 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 93060001054 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 93060001055 DNA binding site [nucleotide binding] 93060001056 catalytic residue [active] 93060001057 H2TH interface [polypeptide binding]; other site 93060001058 putative catalytic residues [active] 93060001059 turnover-facilitating residue; other site 93060001060 intercalation triad [nucleotide binding]; other site 93060001061 8OG recognition residue [nucleotide binding]; other site 93060001062 putative reading head residues; other site 93060001063 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 93060001064 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 93060001065 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 93060001066 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93060001067 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93060001068 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 93060001069 NAD(P) binding site [chemical binding]; other site 93060001070 catalytic residues [active] 93060001071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93060001072 Coenzyme A binding pocket [chemical binding]; other site 93060001073 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 93060001074 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 93060001075 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 93060001076 dinuclear metal binding motif [ion binding]; other site 93060001077 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 93060001078 carotene isomerase; Region: carot_isom; TIGR02730 93060001079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060001080 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 93060001081 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 93060001082 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 93060001083 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93060001084 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93060001085 catalytic triad [active] 93060001086 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 93060001087 hypothetical protein; Provisional; Region: PRK09256 93060001088 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93060001089 CAAX protease self-immunity; Region: Abi; pfam02517 93060001090 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 93060001091 DNA photolyase; Region: DNA_photolyase; pfam00875 93060001092 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 93060001093 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 93060001094 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 93060001095 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 93060001096 substrate binding site [chemical binding]; other site 93060001097 dimer interface [polypeptide binding]; other site 93060001098 ATP binding site [chemical binding]; other site 93060001099 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 93060001100 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 93060001101 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 93060001102 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 93060001103 NAD(P) binding pocket [chemical binding]; other site 93060001104 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 93060001105 Uncharacterized conserved protein [Function unknown]; Region: COG0398 93060001106 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93060001107 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 93060001108 nucleophilic elbow; other site 93060001109 catalytic triad; other site 93060001110 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 93060001111 DXD motif; other site 93060001112 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 93060001113 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 93060001114 putative NAD(P) binding site [chemical binding]; other site 93060001115 active site 93060001116 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 93060001117 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 93060001118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93060001119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060001120 S-adenosylmethionine binding site [chemical binding]; other site 93060001121 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 93060001122 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 93060001123 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 93060001124 TPR repeat; Region: TPR_11; pfam13414 93060001125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060001126 binding surface 93060001127 TPR motif; other site 93060001128 TPR repeat; Region: TPR_11; pfam13414 93060001129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060001130 binding surface 93060001131 TPR motif; other site 93060001132 TPR repeat; Region: TPR_11; pfam13414 93060001133 TPR repeat; Region: TPR_11; pfam13414 93060001134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060001135 TPR repeat; Region: TPR_11; pfam13414 93060001136 binding surface 93060001137 TPR motif; other site 93060001138 TPR repeat; Region: TPR_11; pfam13414 93060001139 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 93060001140 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 93060001141 Bacterial Ig-like domain; Region: Big_5; pfam13205 93060001142 Bacterial Ig-like domain; Region: Big_5; pfam13205 93060001143 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 93060001144 Autotransporter beta-domain; Region: Autotransporter; smart00869 93060001145 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 93060001146 DsrE/DsrF-like family; Region: DrsE; pfam02635 93060001147 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 93060001148 RNase_H superfamily; Region: RNase_H_2; pfam13482 93060001149 AAA domain; Region: AAA_11; pfam13086 93060001150 AAA domain; Region: AAA_30; pfam13604 93060001151 AAA domain; Region: AAA_12; pfam13087 93060001152 Divergent AAA domain; Region: AAA_4; pfam04326 93060001153 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 93060001154 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 93060001155 additional DNA contacts [nucleotide binding]; other site 93060001156 mismatch recognition site; other site 93060001157 active site 93060001158 zinc binding site [ion binding]; other site 93060001159 DNA intercalation site [nucleotide binding]; other site 93060001160 Z1 domain; Region: Z1; pfam10593 93060001161 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 93060001162 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 93060001163 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 93060001164 cofactor binding site; other site 93060001165 DNA binding site [nucleotide binding] 93060001166 substrate interaction site [chemical binding]; other site 93060001167 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 93060001168 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 93060001169 active site 93060001170 DNA binding site [nucleotide binding] 93060001171 Int/Topo IB signature motif; other site 93060001172 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 93060001173 Dehydroquinase class II; Region: DHquinase_II; pfam01220 93060001174 active site 93060001175 trimer interface [polypeptide binding]; other site 93060001176 dimer interface [polypeptide binding]; other site 93060001177 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 93060001178 active site 93060001179 dinuclear metal binding site [ion binding]; other site 93060001180 dimerization interface [polypeptide binding]; other site 93060001181 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 93060001182 active site 93060001183 SAM binding site [chemical binding]; other site 93060001184 homodimer interface [polypeptide binding]; other site 93060001185 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 93060001186 GTP-binding protein Der; Reviewed; Region: PRK00093 93060001187 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 93060001188 G1 box; other site 93060001189 GTP/Mg2+ binding site [chemical binding]; other site 93060001190 Switch I region; other site 93060001191 G2 box; other site 93060001192 Switch II region; other site 93060001193 G3 box; other site 93060001194 G4 box; other site 93060001195 G5 box; other site 93060001196 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 93060001197 G1 box; other site 93060001198 GTP/Mg2+ binding site [chemical binding]; other site 93060001199 Switch I region; other site 93060001200 G2 box; other site 93060001201 G3 box; other site 93060001202 Switch II region; other site 93060001203 G4 box; other site 93060001204 G5 box; other site 93060001205 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 93060001206 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 93060001207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 93060001208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93060001209 catalytic residue [active] 93060001210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 93060001211 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 93060001212 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 93060001213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 93060001214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060001215 Recombination protein O N terminal; Region: RecO_N; pfam11967 93060001216 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 93060001217 Recombination protein O C terminal; Region: RecO_C; pfam02565 93060001218 Class I aldolases; Region: Aldolase_Class_I; cl17187 93060001219 catalytic residue [active] 93060001220 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 93060001221 30S subunit binding site; other site 93060001222 lipoate-protein ligase B; Provisional; Region: PRK14344 93060001223 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 93060001224 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 93060001225 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 93060001226 acyl-activating enzyme (AAE) consensus motif; other site 93060001227 acyl-activating enzyme (AAE) consensus motif; other site 93060001228 putative AMP binding site [chemical binding]; other site 93060001229 putative active site [active] 93060001230 putative CoA binding site [chemical binding]; other site 93060001231 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 93060001232 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 93060001233 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 93060001234 E3 interaction surface; other site 93060001235 lipoyl attachment site [posttranslational modification]; other site 93060001236 e3 binding domain; Region: E3_binding; pfam02817 93060001237 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 93060001238 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 93060001239 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 93060001240 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 93060001241 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 93060001242 dimer interface [polypeptide binding]; other site 93060001243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060001244 catalytic residue [active] 93060001245 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 93060001246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060001247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060001248 catalytic residue [active] 93060001249 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 93060001250 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93060001251 homodimer interface [polypeptide binding]; other site 93060001252 substrate-cofactor binding pocket; other site 93060001253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060001254 catalytic residue [active] 93060001255 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 93060001256 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 93060001257 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93060001258 RNA binding surface [nucleotide binding]; other site 93060001259 hypothetical protein; Provisional; Region: PRK14390 93060001260 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 93060001261 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 93060001262 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93060001263 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93060001264 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 93060001265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060001266 C factor cell-cell signaling protein; Provisional; Region: PRK09009 93060001267 NAD(P) binding site [chemical binding]; other site 93060001268 active site 93060001269 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 93060001270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060001271 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060001272 catalytic residue [active] 93060001273 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93060001274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060001275 S-adenosylmethionine binding site [chemical binding]; other site 93060001276 NifU-like domain; Region: NifU; pfam01106 93060001277 malate:quinone oxidoreductase; Validated; Region: PRK05257 93060001278 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 93060001279 GTP-binding protein LepA; Provisional; Region: PRK05433 93060001280 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 93060001281 G1 box; other site 93060001282 putative GEF interaction site [polypeptide binding]; other site 93060001283 GTP/Mg2+ binding site [chemical binding]; other site 93060001284 Switch I region; other site 93060001285 G2 box; other site 93060001286 G3 box; other site 93060001287 Switch II region; other site 93060001288 G4 box; other site 93060001289 G5 box; other site 93060001290 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 93060001291 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 93060001292 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 93060001293 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 93060001294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060001295 dimer interface [polypeptide binding]; other site 93060001296 conserved gate region; other site 93060001297 ABC-ATPase subunit interface; other site 93060001298 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 93060001299 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93060001300 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 93060001301 Protein of unknown function, DUF393; Region: DUF393; pfam04134 93060001302 TIGR03643 family protein; Region: TIGR03643 93060001303 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 93060001304 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 93060001305 16S rRNA methyltransferase B; Provisional; Region: PRK14901 93060001306 NusB family; Region: NusB; pfam01029 93060001307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060001308 S-adenosylmethionine binding site [chemical binding]; other site 93060001309 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 93060001310 Transglycosylase; Region: Transgly; pfam00912 93060001311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 93060001312 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 93060001313 UbiA prenyltransferase family; Region: UbiA; pfam01040 93060001314 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93060001315 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 93060001316 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 93060001317 substrate binding site [chemical binding]; other site 93060001318 glutamase interaction surface [polypeptide binding]; other site 93060001319 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 93060001320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060001321 S-adenosylmethionine binding site [chemical binding]; other site 93060001322 Protein of unknown function (DUF721); Region: DUF721; pfam05258 93060001323 biotin--protein ligase; Provisional; Region: PRK08330 93060001324 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 93060001325 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93060001326 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93060001327 Walker A/P-loop; other site 93060001328 ATP binding site [chemical binding]; other site 93060001329 Q-loop/lid; other site 93060001330 ABC transporter signature motif; other site 93060001331 Walker B; other site 93060001332 D-loop; other site 93060001333 H-loop/switch region; other site 93060001334 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 93060001335 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93060001336 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 93060001337 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 93060001338 active site 93060001339 metal binding site [ion binding]; metal-binding site 93060001340 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 93060001341 domain I; other site 93060001342 phosphate binding site [ion binding]; other site 93060001343 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 93060001344 domain II; other site 93060001345 domain III; other site 93060001346 nucleotide binding site [chemical binding]; other site 93060001347 DNA binding groove [nucleotide binding] 93060001348 catalytic site [active] 93060001349 domain IV; other site 93060001350 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93060001351 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93060001352 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 93060001353 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 93060001354 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 93060001355 putative dimer interface [polypeptide binding]; other site 93060001356 active site pocket [active] 93060001357 putative cataytic base [active] 93060001358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 93060001359 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 93060001360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 93060001361 active site 93060001362 catalytic tetrad [active] 93060001363 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 93060001364 Lumazine binding domain; Region: Lum_binding; pfam00677 93060001365 Lumazine binding domain; Region: Lum_binding; pfam00677 93060001366 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 93060001367 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 93060001368 Subunit I/III interface [polypeptide binding]; other site 93060001369 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 93060001370 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 93060001371 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 93060001372 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 93060001373 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 93060001374 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 93060001375 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 93060001376 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 93060001377 UbiA prenyltransferase family; Region: UbiA; pfam01040 93060001378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 93060001379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060001380 Walker A/P-loop; other site 93060001381 ATP binding site [chemical binding]; other site 93060001382 Q-loop/lid; other site 93060001383 ABC transporter signature motif; other site 93060001384 Walker B; other site 93060001385 D-loop; other site 93060001386 H-loop/switch region; other site 93060001387 ABC-2 type transporter; Region: ABC2_membrane; cl17235 93060001388 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 93060001389 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 93060001390 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 93060001391 ring oligomerisation interface [polypeptide binding]; other site 93060001392 ATP/Mg binding site [chemical binding]; other site 93060001393 stacking interactions; other site 93060001394 hinge regions; other site 93060001395 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 93060001396 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 93060001397 NAD(P) binding site [chemical binding]; other site 93060001398 homotetramer interface [polypeptide binding]; other site 93060001399 homodimer interface [polypeptide binding]; other site 93060001400 active site 93060001401 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 93060001402 substrate binding site; other site 93060001403 dimer interface; other site 93060001404 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 93060001405 dimer interface [polypeptide binding]; other site 93060001406 catalytic triad [active] 93060001407 prenyltransferase; Reviewed; Region: ubiA; PRK12873 93060001408 UbiA prenyltransferase family; Region: UbiA; pfam01040 93060001409 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 93060001410 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 93060001411 Helix-turn-helix domain; Region: HTH_25; pfam13413 93060001412 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 93060001413 active site 93060001414 SAM binding site [chemical binding]; other site 93060001415 homodimer interface [polypeptide binding]; other site 93060001416 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 93060001417 cytochrome f; Region: petA; CHL00037 93060001418 apocytochrome f; Reviewed; Region: PRK02693 93060001419 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 93060001420 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 93060001421 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 93060001422 cytochrome b subunit interaction site [polypeptide binding]; other site 93060001423 [2Fe-2S] cluster binding site [ion binding]; other site 93060001424 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 93060001425 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 93060001426 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 93060001427 Domain of unknown function (DUF814); Region: DUF814; pfam05670 93060001428 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 93060001429 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 93060001430 catalytic site [active] 93060001431 G-X2-G-X-G-K; other site 93060001432 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 93060001433 UGMP family protein; Validated; Region: PRK09604 93060001434 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 93060001435 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 93060001436 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 93060001437 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060001438 active site 93060001439 HIGH motif; other site 93060001440 nucleotide binding site [chemical binding]; other site 93060001441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 93060001442 active site 93060001443 KMSKS motif; other site 93060001444 Src Homology 3 domain superfamily; Region: SH3; cl17036 93060001445 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 93060001446 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 93060001447 active site 93060001448 short chain dehydrogenase; Provisional; Region: PRK12367 93060001449 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 93060001450 DRTGG domain; Region: DRTGG; pfam07085 93060001451 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 93060001452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 93060001453 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 93060001454 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 93060001455 SPFH domain / Band 7 family; Region: Band_7; pfam01145 93060001456 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 93060001457 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93060001458 inhibitor-cofactor binding pocket; inhibition site 93060001459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060001460 catalytic residue [active] 93060001461 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 93060001462 putative catalytic site [active] 93060001463 putative phosphate binding site [ion binding]; other site 93060001464 active site 93060001465 metal binding site A [ion binding]; metal-binding site 93060001466 DNA binding site [nucleotide binding] 93060001467 putative AP binding site [nucleotide binding]; other site 93060001468 putative metal binding site B [ion binding]; other site 93060001469 hypothetical protein; Provisional; Region: PRK04194 93060001470 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 93060001471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060001472 dimer interface [polypeptide binding]; other site 93060001473 conserved gate region; other site 93060001474 putative PBP binding loops; other site 93060001475 ABC-ATPase subunit interface; other site 93060001476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060001477 dimer interface [polypeptide binding]; other site 93060001478 conserved gate region; other site 93060001479 putative PBP binding loops; other site 93060001480 ABC-ATPase subunit interface; other site 93060001481 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93060001482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060001483 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93060001484 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 93060001485 aromatic arch; other site 93060001486 DCoH dimer interaction site [polypeptide binding]; other site 93060001487 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 93060001488 DCoH tetramer interaction site [polypeptide binding]; other site 93060001489 substrate binding site [chemical binding]; other site 93060001490 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 93060001491 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 93060001492 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 93060001493 active site 93060001494 Zn binding site [ion binding]; other site 93060001495 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 93060001496 dimer interface [polypeptide binding]; other site 93060001497 substrate binding site [chemical binding]; other site 93060001498 metal binding sites [ion binding]; metal-binding site 93060001499 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 93060001500 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 93060001501 domain interfaces; other site 93060001502 active site 93060001503 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93060001504 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93060001505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93060001506 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93060001507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93060001508 DNA binding residues [nucleotide binding] 93060001509 primosome assembly protein PriA; Validated; Region: PRK05580 93060001510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060001511 ATP binding site [chemical binding]; other site 93060001512 putative Mg++ binding site [ion binding]; other site 93060001513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060001514 ATP-binding site [chemical binding]; other site 93060001515 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 93060001516 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 93060001517 feedback inhibition sensing region; other site 93060001518 homohexameric interface [polypeptide binding]; other site 93060001519 nucleotide binding site [chemical binding]; other site 93060001520 N-acetyl-L-glutamate binding site [chemical binding]; other site 93060001521 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 93060001522 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93060001523 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93060001524 ssDNA binding site [nucleotide binding]; other site 93060001525 dimer interface [polypeptide binding]; other site 93060001526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93060001527 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 93060001528 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 93060001529 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 93060001530 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 93060001531 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93060001532 substrate binding site [chemical binding]; other site 93060001533 ATP binding site [chemical binding]; other site 93060001534 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 93060001535 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 93060001536 GDP-binding site [chemical binding]; other site 93060001537 ACT binding site; other site 93060001538 IMP binding site; other site 93060001539 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 93060001540 prolyl-tRNA synthetase; Provisional; Region: PRK09194 93060001541 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 93060001542 dimer interface [polypeptide binding]; other site 93060001543 motif 1; other site 93060001544 active site 93060001545 motif 2; other site 93060001546 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 93060001547 putative deacylase active site [active] 93060001548 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 93060001549 motif 3; other site 93060001550 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 93060001551 anticodon binding site; other site 93060001552 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 93060001553 dimer interface [polypeptide binding]; other site 93060001554 substrate binding site [chemical binding]; other site 93060001555 metal binding sites [ion binding]; metal-binding site 93060001556 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 93060001557 ArsC family; Region: ArsC; pfam03960 93060001558 putative ArsC-like catalytic residues; other site 93060001559 putative TRX-like catalytic residues [active] 93060001560 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93060001561 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93060001562 Catalytic site [active] 93060001563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93060001564 catalytic core [active] 93060001565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 93060001566 catalytic core [active] 93060001567 CAAX protease self-immunity; Region: Abi; pfam02517 93060001568 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 93060001569 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 93060001570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 93060001571 transaldolase-like protein; Provisional; Region: PTZ00411 93060001572 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 93060001573 active site 93060001574 dimer interface [polypeptide binding]; other site 93060001575 catalytic residue [active] 93060001576 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 93060001577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060001578 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 93060001579 ribosome recycling factor; Reviewed; Region: frr; PRK00083 93060001580 hinge region; other site 93060001581 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 93060001582 putative nucleotide binding site [chemical binding]; other site 93060001583 uridine monophosphate binding site [chemical binding]; other site 93060001584 homohexameric interface [polypeptide binding]; other site 93060001585 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 93060001586 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 93060001587 homodimer interface [polypeptide binding]; other site 93060001588 Walker A motif; other site 93060001589 ATP binding site [chemical binding]; other site 93060001590 hydroxycobalamin binding site [chemical binding]; other site 93060001591 Walker B motif; other site 93060001592 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 93060001593 active site 93060001594 catalytic residues [active] 93060001595 DNA binding site [nucleotide binding] 93060001596 Int/Topo IB signature motif; other site 93060001597 ferrochelatase; Reviewed; Region: hemH; PRK00035 93060001598 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 93060001599 C-terminal domain interface [polypeptide binding]; other site 93060001600 active site 93060001601 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 93060001602 active site 93060001603 N-terminal domain interface [polypeptide binding]; other site 93060001604 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 93060001605 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 93060001606 PYR/PP interface [polypeptide binding]; other site 93060001607 dimer interface [polypeptide binding]; other site 93060001608 TPP binding site [chemical binding]; other site 93060001609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 93060001610 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 93060001611 TPP-binding site [chemical binding]; other site 93060001612 dimer interface [polypeptide binding]; other site 93060001613 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 93060001614 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 93060001615 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 93060001616 RNA binding site [nucleotide binding]; other site 93060001617 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 93060001618 RNA binding site [nucleotide binding]; other site 93060001619 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 93060001620 RNA binding site [nucleotide binding]; other site 93060001621 Creatinine amidohydrolase; Region: Creatininase; pfam02633 93060001622 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 93060001623 dinuclear metal binding motif [ion binding]; other site 93060001624 acyl-ACP reductase; Provisional; Region: PRK14982 93060001625 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 93060001626 NAD(P) binding pocket [chemical binding]; other site 93060001627 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 93060001628 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 93060001629 short chain dehydrogenase; Provisional; Region: PRK07454 93060001630 classical (c) SDRs; Region: SDR_c; cd05233 93060001631 NAD(P) binding site [chemical binding]; other site 93060001632 active site 93060001633 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 93060001634 GTP cyclohydrolase I; Provisional; Region: PLN03044 93060001635 active site 93060001636 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 93060001637 active site 93060001638 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 93060001639 active site 93060001640 putative substrate binding region [chemical binding]; other site 93060001641 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 93060001642 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 93060001643 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 93060001644 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 93060001645 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 93060001646 NAD(P) binding site [chemical binding]; other site 93060001647 active site 93060001648 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 93060001649 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 93060001650 P-loop; other site 93060001651 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 93060001652 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 93060001653 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 93060001654 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 93060001655 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 93060001656 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 93060001657 putative hexamer interface [polypeptide binding]; other site 93060001658 putative hexagonal pore; other site 93060001659 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 93060001660 putative hexamer interface [polypeptide binding]; other site 93060001661 putative hexagonal pore; other site 93060001662 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 93060001663 active site 93060001664 dimerization interface [polypeptide binding]; other site 93060001665 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 93060001666 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 93060001667 Hexamer interface [polypeptide binding]; other site 93060001668 Hexagonal pore residue; other site 93060001669 Hexagonal pore; other site 93060001670 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 93060001671 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 93060001672 dimer interface [polypeptide binding]; other site 93060001673 catalytic residue [active] 93060001674 metal binding site [ion binding]; metal-binding site 93060001675 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 93060001676 multimerization interface [polypeptide binding]; other site 93060001677 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 93060001678 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 93060001679 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 93060001680 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 93060001681 Hexamer/Pentamer interface [polypeptide binding]; other site 93060001682 central pore; other site 93060001683 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 93060001684 Hexamer/Pentamer interface [polypeptide binding]; other site 93060001685 central pore; other site 93060001686 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 93060001687 DCoH dimer interaction site [polypeptide binding]; other site 93060001688 aromatic arch; other site 93060001689 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 93060001690 DCoH tetramer interaction site [polypeptide binding]; other site 93060001691 substrate binding site [chemical binding]; other site 93060001692 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 93060001693 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 93060001694 homotrimer interaction site [polypeptide binding]; other site 93060001695 putative active site [active] 93060001696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93060001697 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 93060001698 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 93060001699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93060001700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93060001701 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 93060001702 Walker A/P-loop; other site 93060001703 ATP binding site [chemical binding]; other site 93060001704 Q-loop/lid; other site 93060001705 ABC transporter signature motif; other site 93060001706 Walker B; other site 93060001707 D-loop; other site 93060001708 H-loop/switch region; other site 93060001709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93060001710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93060001711 Coenzyme A binding pocket [chemical binding]; other site 93060001712 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 93060001713 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 93060001714 Probable Catalytic site; other site 93060001715 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 93060001716 DnaA N-terminal domain; Region: DnaA_N; pfam11638 93060001717 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 93060001718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060001719 Walker A motif; other site 93060001720 ATP binding site [chemical binding]; other site 93060001721 Walker B motif; other site 93060001722 arginine finger; other site 93060001723 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 93060001724 DnaA box-binding interface [nucleotide binding]; other site 93060001725 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 93060001726 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93060001727 C-terminal domain interface [polypeptide binding]; other site 93060001728 GSH binding site (G-site) [chemical binding]; other site 93060001729 dimer interface [polypeptide binding]; other site 93060001730 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 93060001731 glutathione reductase; Validated; Region: PRK06116 93060001732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93060001733 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 93060001734 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 93060001735 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 93060001736 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 93060001737 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 93060001738 active site 93060001739 substrate binding pocket [chemical binding]; other site 93060001740 dimer interface [polypeptide binding]; other site 93060001741 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 93060001742 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 93060001743 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 93060001744 substrate binding site [chemical binding]; other site 93060001745 active site 93060001746 catalytic residues [active] 93060001747 heterodimer interface [polypeptide binding]; other site 93060001748 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 93060001749 YciI-like protein; Reviewed; Region: PRK12864 93060001750 Uncharacterized conserved protein [Function unknown]; Region: COG3339 93060001751 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93060001752 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93060001753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93060001754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93060001755 DNA binding residues [nucleotide binding] 93060001756 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 93060001757 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 93060001758 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 93060001759 metal binding site [ion binding]; metal-binding site 93060001760 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 93060001761 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 93060001762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060001763 Walker A motif; other site 93060001764 ATP binding site [chemical binding]; other site 93060001765 Walker B motif; other site 93060001766 arginine finger; other site 93060001767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060001768 Walker A motif; other site 93060001769 ATP binding site [chemical binding]; other site 93060001770 Walker B motif; other site 93060001771 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93060001772 plastocyanin; Provisional; Region: PRK02710 93060001773 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 93060001774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060001775 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 93060001776 NAD(P) binding site [chemical binding]; other site 93060001777 active site 93060001778 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 93060001779 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 93060001780 substrate binding site [chemical binding]; other site 93060001781 active site 93060001782 glycogen branching enzyme; Provisional; Region: PRK05402 93060001783 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 93060001784 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 93060001785 active site 93060001786 catalytic site [active] 93060001787 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 93060001788 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 93060001789 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 93060001790 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 93060001791 Protein of function (DUF2518); Region: DUF2518; pfam10726 93060001792 Family of unknown function (DUF490); Region: DUF490; pfam04357 93060001793 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 93060001794 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 93060001795 putative catalytic cysteine [active] 93060001796 Dihydroneopterin aldolase; Region: FolB; smart00905 93060001797 active site 93060001798 Lipase (class 2); Region: Lipase_2; pfam01674 93060001799 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 93060001800 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 93060001801 active site 93060001802 Zn binding site [ion binding]; other site 93060001803 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 93060001804 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 93060001805 homoserine kinase; Provisional; Region: PRK01212 93060001806 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93060001807 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93060001808 glucokinase, proteobacterial type; Region: glk; TIGR00749 93060001809 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 93060001810 nucleotide binding site [chemical binding]; other site 93060001811 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 93060001812 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 93060001813 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 93060001814 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 93060001815 active site 93060001816 dimer interface [polypeptide binding]; other site 93060001817 motif 1; other site 93060001818 motif 2; other site 93060001819 motif 3; other site 93060001820 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 93060001821 anticodon binding site; other site 93060001822 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 93060001823 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 93060001824 active site 93060001825 HIGH motif; other site 93060001826 dimer interface [polypeptide binding]; other site 93060001827 KMSKS motif; other site 93060001828 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93060001829 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 93060001830 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 93060001831 metal binding site [ion binding]; metal-binding site 93060001832 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 93060001833 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93060001834 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 93060001835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93060001836 ABC-ATPase subunit interface; other site 93060001837 dimer interface [polypeptide binding]; other site 93060001838 putative PBP binding regions; other site 93060001839 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 93060001840 Protein of unknown function (DUF760); Region: DUF760; pfam05542 93060001841 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 93060001842 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93060001843 Catalytic site [active] 93060001844 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 93060001845 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 93060001846 dimer interface [polypeptide binding]; other site 93060001847 tetramer interface [polypeptide binding]; other site 93060001848 PYR/PP interface [polypeptide binding]; other site 93060001849 TPP binding site [chemical binding]; other site 93060001850 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 93060001851 TPP-binding site; other site 93060001852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 93060001853 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 93060001854 substrate binding site [chemical binding]; other site 93060001855 oxyanion hole (OAH) forming residues; other site 93060001856 trimer interface [polypeptide binding]; other site 93060001857 glycogen synthase; Provisional; Region: glgA; PRK00654 93060001858 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 93060001859 ADP-binding pocket [chemical binding]; other site 93060001860 homodimer interface [polypeptide binding]; other site 93060001861 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 93060001862 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 93060001863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93060001864 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 93060001865 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 93060001866 Substrate binding site; other site 93060001867 Mg++ binding site; other site 93060001868 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 93060001869 active site 93060001870 substrate binding site [chemical binding]; other site 93060001871 CoA binding site [chemical binding]; other site 93060001872 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 93060001873 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 93060001874 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 93060001875 hinge; other site 93060001876 active site 93060001877 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 93060001878 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 93060001879 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 93060001880 nitrilase; Region: PLN02798 93060001881 putative active site [active] 93060001882 catalytic triad [active] 93060001883 dimer interface [polypeptide binding]; other site 93060001884 AMIN domain; Region: AMIN; pfam11741 93060001885 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 93060001886 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 93060001887 active site 93060001888 metal binding site [ion binding]; metal-binding site 93060001889 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 93060001890 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 93060001891 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93060001892 substrate binding pocket [chemical binding]; other site 93060001893 chain length determination region; other site 93060001894 substrate-Mg2+ binding site; other site 93060001895 catalytic residues [active] 93060001896 aspartate-rich region 1; other site 93060001897 active site lid residues [active] 93060001898 aspartate-rich region 2; other site 93060001899 acetyl-CoA synthetase; Provisional; Region: PRK00174 93060001900 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 93060001901 active site 93060001902 CoA binding site [chemical binding]; other site 93060001903 acyl-activating enzyme (AAE) consensus motif; other site 93060001904 AMP binding site [chemical binding]; other site 93060001905 acetate binding site [chemical binding]; other site 93060001906 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 93060001907 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 93060001908 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 93060001909 active site 93060001910 catalytic site [active] 93060001911 substrate binding site [chemical binding]; other site 93060001912 GLTT repeat (6 copies); Region: GLTT; pfam01744 93060001913 GLTT repeat (6 copies); Region: GLTT; pfam01744 93060001914 Protein of unknown function; Region: DUF3721; pfam12518 93060001915 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 93060001916 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 93060001917 dimer interface [polypeptide binding]; other site 93060001918 motif 1; other site 93060001919 active site 93060001920 motif 2; other site 93060001921 motif 3; other site 93060001922 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 93060001923 anticodon binding site; other site 93060001924 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 93060001925 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93060001926 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 93060001927 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 93060001928 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 93060001929 putative GSH binding site (G-site) [chemical binding]; other site 93060001930 active site cysteine [active] 93060001931 putative C-terminal domain interface [polypeptide binding]; other site 93060001932 putative dimer interface [polypeptide binding]; other site 93060001933 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 93060001934 putative N-terminal domain interface [polypeptide binding]; other site 93060001935 putative dimer interface [polypeptide binding]; other site 93060001936 putative substrate binding pocket (H-site) [chemical binding]; other site 93060001937 T5orf172 domain; Region: T5orf172; pfam10544 93060001938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060001939 short chain dehydrogenase; Provisional; Region: PRK07326 93060001940 NAD(P) binding site [chemical binding]; other site 93060001941 active site 93060001942 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 93060001943 lycopene cyclase; Region: lycopene_cycl; TIGR01789 93060001944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060001945 protochlorophyllide reductase; Region: PLN00015 93060001946 NAD(P) binding site [chemical binding]; other site 93060001947 active site 93060001948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 93060001949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 93060001950 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 93060001951 Isochorismatase family; Region: Isochorismatase; pfam00857 93060001952 catalytic triad [active] 93060001953 dimer interface [polypeptide binding]; other site 93060001954 conserved cis-peptide bond; other site 93060001955 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93060001956 metal binding site 2 [ion binding]; metal-binding site 93060001957 putative DNA binding helix; other site 93060001958 metal binding site 1 [ion binding]; metal-binding site 93060001959 dimer interface [polypeptide binding]; other site 93060001960 structural Zn2+ binding site [ion binding]; other site 93060001961 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 93060001962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060001963 FeS/SAM binding site; other site 93060001964 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 93060001965 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 93060001966 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 93060001967 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 93060001968 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 93060001969 homodimer interface [polypeptide binding]; other site 93060001970 substrate-cofactor binding pocket; other site 93060001971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060001972 catalytic residue [active] 93060001973 Homoserine O-succinyltransferase; Region: HTS; pfam04204 93060001974 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 93060001975 conserved cys residue [active] 93060001976 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 93060001977 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 93060001978 Sulfate transporter family; Region: Sulfate_transp; pfam00916 93060001979 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 93060001980 FAD binding domain; Region: FAD_binding_4; pfam01565 93060001981 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 93060001982 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 93060001983 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 93060001984 putative active site [active] 93060001985 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 93060001986 putative active site [active] 93060001987 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 93060001988 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 93060001989 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 93060001990 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060001991 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93060001992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060001993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 93060001994 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 93060001995 dimer interface [polypeptide binding]; other site 93060001996 active site 93060001997 metal binding site [ion binding]; metal-binding site 93060001998 glutathione binding site [chemical binding]; other site 93060001999 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 93060002000 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 93060002001 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 93060002002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060002003 S-adenosylmethionine binding site [chemical binding]; other site 93060002004 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 93060002005 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 93060002006 G1 box; other site 93060002007 putative GEF interaction site [polypeptide binding]; other site 93060002008 GTP/Mg2+ binding site [chemical binding]; other site 93060002009 Switch I region; other site 93060002010 G2 box; other site 93060002011 G3 box; other site 93060002012 Switch II region; other site 93060002013 G4 box; other site 93060002014 G5 box; other site 93060002015 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 93060002016 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 93060002017 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 93060002018 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 93060002019 dimerization interface [polypeptide binding]; other site 93060002020 domain crossover interface; other site 93060002021 redox-dependent activation switch; other site 93060002022 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93060002023 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 93060002024 Walker A/P-loop; other site 93060002025 ATP binding site [chemical binding]; other site 93060002026 Q-loop/lid; other site 93060002027 ABC transporter signature motif; other site 93060002028 Walker B; other site 93060002029 D-loop; other site 93060002030 H-loop/switch region; other site 93060002031 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 93060002032 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 93060002033 RNA methyltransferase, RsmE family; Region: TIGR00046 93060002034 Integral membrane protein DUF92; Region: DUF92; pfam01940 93060002035 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 93060002036 active site 93060002037 catalytic triad [active] 93060002038 oxyanion hole [active] 93060002039 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 93060002040 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 93060002041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060002042 Walker A/P-loop; other site 93060002043 ATP binding site [chemical binding]; other site 93060002044 Q-loop/lid; other site 93060002045 ABC transporter signature motif; other site 93060002046 Walker B; other site 93060002047 D-loop; other site 93060002048 H-loop/switch region; other site 93060002049 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 93060002050 aspartate aminotransferase; Provisional; Region: PRK05764 93060002051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93060002052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060002053 homodimer interface [polypeptide binding]; other site 93060002054 catalytic residue [active] 93060002055 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 93060002056 active site 93060002057 Fe-S cluster binding site [ion binding]; other site 93060002058 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 93060002059 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 93060002060 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 93060002061 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 93060002062 C-terminal peptidase (prc); Region: prc; TIGR00225 93060002063 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93060002064 protein binding site [polypeptide binding]; other site 93060002065 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 93060002066 Catalytic dyad [active] 93060002067 quinolinate synthetase; Provisional; Region: PRK09375 93060002068 TIGR04168 family protein; Region: TIGR04168 93060002069 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 93060002070 Repair protein; Region: Repair_PSII; pfam04536 93060002071 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 93060002072 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 93060002073 active site 93060002074 dimer interface [polypeptide binding]; other site 93060002075 metal binding site [ion binding]; metal-binding site 93060002076 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 93060002077 ATP-grasp domain; Region: ATP-grasp; pfam02222 93060002078 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 93060002079 Protein of unknown function; Region: DUF3721; pfam12518 93060002080 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93060002081 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 93060002082 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 93060002083 nucleotide binding pocket [chemical binding]; other site 93060002084 K-X-D-G motif; other site 93060002085 catalytic site [active] 93060002086 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93060002087 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 93060002088 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 93060002089 C factor cell-cell signaling protein; Provisional; Region: PRK09009 93060002090 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 93060002091 NADP binding site [chemical binding]; other site 93060002092 homodimer interface [polypeptide binding]; other site 93060002093 active site 93060002094 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93060002095 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 93060002096 Ion channel; Region: Ion_trans_2; pfam07885 93060002097 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 93060002098 TrkA-N domain; Region: TrkA_N; pfam02254 93060002099 TrkA-C domain; Region: TrkA_C; pfam02080 93060002100 PBP superfamily domain; Region: PBP_like_2; cl17296 93060002101 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 93060002102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060002103 dimer interface [polypeptide binding]; other site 93060002104 conserved gate region; other site 93060002105 ABC-ATPase subunit interface; other site 93060002106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 93060002107 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 93060002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060002109 dimer interface [polypeptide binding]; other site 93060002110 conserved gate region; other site 93060002111 putative PBP binding loops; other site 93060002112 ABC-ATPase subunit interface; other site 93060002113 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 93060002114 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 93060002115 Walker A/P-loop; other site 93060002116 ATP binding site [chemical binding]; other site 93060002117 Q-loop/lid; other site 93060002118 ABC transporter signature motif; other site 93060002119 Walker B; other site 93060002120 D-loop; other site 93060002121 H-loop/switch region; other site 93060002122 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 93060002123 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 93060002124 putative active site [active] 93060002125 putative metal binding site [ion binding]; other site 93060002126 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 93060002127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060002128 ATP binding site [chemical binding]; other site 93060002129 putative Mg++ binding site [ion binding]; other site 93060002130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060002131 nucleotide binding region [chemical binding]; other site 93060002132 ATP-binding site [chemical binding]; other site 93060002133 DEAD/H associated; Region: DEAD_assoc; pfam08494 93060002134 ATP-dependent DNA ligase; Validated; Region: PRK09247 93060002135 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 93060002136 active site 93060002137 DNA binding site [nucleotide binding] 93060002138 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 93060002139 DNA binding site [nucleotide binding] 93060002140 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 93060002141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 93060002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 93060002143 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 93060002144 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 93060002145 Thf1-like protein; Reviewed; Region: PRK13266 93060002146 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 93060002147 Clp protease; Region: CLP_protease; pfam00574 93060002148 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93060002149 oligomer interface [polypeptide binding]; other site 93060002150 active site residues [active] 93060002151 cell division protein; Validated; Region: ftsH; CHL00176 93060002152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060002153 Walker A motif; other site 93060002154 ATP binding site [chemical binding]; other site 93060002155 Walker B motif; other site 93060002156 arginine finger; other site 93060002157 Peptidase family M41; Region: Peptidase_M41; pfam01434 93060002158 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 93060002159 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93060002160 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 93060002161 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93060002162 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 93060002163 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 93060002164 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 93060002165 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 93060002166 HlyD family secretion protein; Region: HlyD_3; pfam13437 93060002167 DevC protein; Region: devC; TIGR01185 93060002168 FtsX-like permease family; Region: FtsX; pfam02687 93060002169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 93060002170 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 93060002171 Walker A/P-loop; other site 93060002172 ATP binding site [chemical binding]; other site 93060002173 Q-loop/lid; other site 93060002174 ABC transporter signature motif; other site 93060002175 Walker B; other site 93060002176 D-loop; other site 93060002177 H-loop/switch region; other site 93060002178 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 93060002179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93060002180 active site 93060002181 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 93060002182 rRNA interaction site [nucleotide binding]; other site 93060002183 S8 interaction site; other site 93060002184 putative laminin-1 binding site; other site 93060002185 elongation factor Ts; Reviewed; Region: tsf; PRK12332 93060002186 UBA/TS-N domain; Region: UBA; pfam00627 93060002187 Elongation factor TS; Region: EF_TS; pfam00889 93060002188 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 93060002189 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 93060002190 generic binding surface II; other site 93060002191 ssDNA binding site; other site 93060002192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060002193 ATP binding site [chemical binding]; other site 93060002194 putative Mg++ binding site [ion binding]; other site 93060002195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060002196 nucleotide binding region [chemical binding]; other site 93060002197 ATP-binding site [chemical binding]; other site 93060002198 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 93060002199 sulfite reductase subunit beta; Provisional; Region: PRK13504 93060002200 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 93060002201 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 93060002202 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 93060002203 geranylgeranyl reductase; Region: ChlP; TIGR02028 93060002204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93060002205 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 93060002206 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 93060002207 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 93060002208 G1 box; other site 93060002209 putative GEF interaction site [polypeptide binding]; other site 93060002210 GTP/Mg2+ binding site [chemical binding]; other site 93060002211 Switch I region; other site 93060002212 G2 box; other site 93060002213 G3 box; other site 93060002214 Switch II region; other site 93060002215 G4 box; other site 93060002216 G5 box; other site 93060002217 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 93060002218 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 93060002219 Domain of unknown function (DUF309); Region: DUF309; pfam03745 93060002220 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 93060002221 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 93060002222 Walker A/P-loop; other site 93060002223 ATP binding site [chemical binding]; other site 93060002224 Q-loop/lid; other site 93060002225 ABC transporter signature motif; other site 93060002226 Walker B; other site 93060002227 D-loop; other site 93060002228 H-loop/switch region; other site 93060002229 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 93060002230 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 93060002231 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 93060002232 substrate binding site [chemical binding]; other site 93060002233 hexamer interface [polypeptide binding]; other site 93060002234 metal binding site [ion binding]; metal-binding site 93060002235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 93060002236 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 93060002237 putative active site [active] 93060002238 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 93060002239 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 93060002240 tRNA; other site 93060002241 putative tRNA binding site [nucleotide binding]; other site 93060002242 putative NADP binding site [chemical binding]; other site 93060002243 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 93060002244 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 93060002245 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 93060002246 ligand binding site; other site 93060002247 oligomer interface; other site 93060002248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93060002249 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 93060002250 dimer interface [polypeptide binding]; other site 93060002251 N-terminal domain interface [polypeptide binding]; other site 93060002252 sulfate 1 binding site; other site 93060002253 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 93060002254 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 93060002255 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 93060002256 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 93060002257 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 93060002258 putative active site [active] 93060002259 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 93060002260 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 93060002261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 93060002262 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 93060002263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060002264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060002265 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 93060002266 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 93060002267 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93060002268 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 93060002269 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 93060002270 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 93060002271 putative active site [active] 93060002272 catalytic triad [active] 93060002273 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 93060002274 active site 93060002275 intersubunit interface [polypeptide binding]; other site 93060002276 catalytic residue [active] 93060002277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93060002278 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93060002279 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 93060002280 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 93060002281 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 93060002282 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 93060002283 active site 93060002284 tartrate dehydrogenase; Region: TTC; TIGR02089 93060002285 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 93060002286 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 93060002287 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 93060002288 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 93060002289 trimer interface [polypeptide binding]; other site 93060002290 active site 93060002291 UDP-GlcNAc binding site [chemical binding]; other site 93060002292 lipid binding site [chemical binding]; lipid-binding site 93060002293 gamma-glutamyl kinase; Provisional; Region: PRK05429 93060002294 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 93060002295 nucleotide binding site [chemical binding]; other site 93060002296 homotetrameric interface [polypeptide binding]; other site 93060002297 putative phosphate binding site [ion binding]; other site 93060002298 putative allosteric binding site; other site 93060002299 PUA domain; Region: PUA; pfam01472 93060002300 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 93060002301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060002302 active site 93060002303 motif I; other site 93060002304 motif II; other site 93060002305 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 93060002306 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 93060002307 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 93060002308 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93060002309 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 93060002310 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 93060002311 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 93060002312 catalytic residues [active] 93060002313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060002315 NAD(P) binding site [chemical binding]; other site 93060002316 active site 93060002317 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 93060002318 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 93060002319 trimer interface [polypeptide binding]; other site 93060002320 putative Zn binding site [ion binding]; other site 93060002321 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 93060002322 GSH binding site [chemical binding]; other site 93060002323 catalytic residues [active] 93060002324 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 93060002325 NADH(P)-binding; Region: NAD_binding_10; pfam13460 93060002326 NAD(P) binding site [chemical binding]; other site 93060002327 putative active site [active] 93060002328 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 93060002329 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 93060002330 minor groove reading motif; other site 93060002331 helix-hairpin-helix signature motif; other site 93060002332 substrate binding pocket [chemical binding]; other site 93060002333 active site 93060002334 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 93060002335 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 93060002336 Walker A/P-loop; other site 93060002337 ATP binding site [chemical binding]; other site 93060002338 Q-loop/lid; other site 93060002339 ABC transporter signature motif; other site 93060002340 Walker B; other site 93060002341 D-loop; other site 93060002342 H-loop/switch region; other site 93060002343 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 93060002344 Ferritin-like domain; Region: Ferritin; pfam00210 93060002345 ferroxidase diiron center [ion binding]; other site 93060002346 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 93060002347 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 93060002348 putative switch regulator; other site 93060002349 non-specific DNA interactions [nucleotide binding]; other site 93060002350 DNA binding site [nucleotide binding] 93060002351 sequence specific DNA binding site [nucleotide binding]; other site 93060002352 putative cAMP binding site [chemical binding]; other site 93060002353 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 93060002354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060002355 Walker A/P-loop; other site 93060002356 ATP binding site [chemical binding]; other site 93060002357 Q-loop/lid; other site 93060002358 ABC transporter signature motif; other site 93060002359 Walker B; other site 93060002360 D-loop; other site 93060002361 H-loop/switch region; other site 93060002362 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 93060002363 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 93060002364 [2Fe-2S] cluster binding site [ion binding]; other site 93060002365 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 93060002366 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 93060002367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 93060002368 Walker A/P-loop; other site 93060002369 ATP binding site [chemical binding]; other site 93060002370 Q-loop/lid; other site 93060002371 ABC transporter signature motif; other site 93060002372 Walker B; other site 93060002373 D-loop; other site 93060002374 H-loop/switch region; other site 93060002375 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 93060002376 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 93060002377 Walker A/P-loop; other site 93060002378 ATP binding site [chemical binding]; other site 93060002379 Q-loop/lid; other site 93060002380 ABC transporter signature motif; other site 93060002381 Walker B; other site 93060002382 D-loop; other site 93060002383 H-loop/switch region; other site 93060002384 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 93060002385 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 93060002386 TM-ABC transporter signature motif; other site 93060002387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 93060002388 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 93060002389 TM-ABC transporter signature motif; other site 93060002390 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 93060002391 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 93060002392 putative ligand binding site [chemical binding]; other site 93060002393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060002394 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 93060002395 UreF; Region: UreF; pfam01730 93060002396 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 93060002397 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 93060002398 dimer interface [polypeptide binding]; other site 93060002399 catalytic residues [active] 93060002400 UreD urease accessory protein; Region: UreD; pfam01774 93060002401 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 93060002402 alpha-gamma subunit interface [polypeptide binding]; other site 93060002403 beta-gamma subunit interface [polypeptide binding]; other site 93060002404 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 93060002405 alpha-beta subunit interface [polypeptide binding]; other site 93060002406 urease subunit alpha; Reviewed; Region: ureC; PRK13207 93060002407 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 93060002408 subunit interactions [polypeptide binding]; other site 93060002409 active site 93060002410 flap region; other site 93060002411 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 93060002412 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 93060002413 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 93060002414 active site 93060002415 homodimer interface [polypeptide binding]; other site 93060002416 catalytic site [active] 93060002417 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 93060002418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060002419 active site 93060002420 motif I; other site 93060002421 motif II; other site 93060002422 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 93060002423 active site 93060002424 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 93060002425 Bacitracin resistance protein BacA; Region: BacA; pfam02673 93060002426 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 93060002427 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93060002428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93060002429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060002430 Walker A/P-loop; other site 93060002431 ATP binding site [chemical binding]; other site 93060002432 Q-loop/lid; other site 93060002433 ABC transporter signature motif; other site 93060002434 Walker B; other site 93060002435 D-loop; other site 93060002436 H-loop/switch region; other site 93060002437 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 93060002438 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 93060002439 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 93060002440 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 93060002441 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 93060002442 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 93060002443 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 93060002444 catalytic site [active] 93060002445 subunit interface [polypeptide binding]; other site 93060002446 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 93060002447 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 93060002448 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 93060002449 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93060002450 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 93060002451 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 93060002452 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 93060002453 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 93060002454 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 93060002455 active site 93060002456 PHP Thumb interface [polypeptide binding]; other site 93060002457 metal binding site [ion binding]; metal-binding site 93060002458 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 93060002459 generic binding surface I; other site 93060002460 generic binding surface II; other site 93060002461 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 93060002462 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 93060002463 16S/18S rRNA binding site [nucleotide binding]; other site 93060002464 S13e-L30e interaction site [polypeptide binding]; other site 93060002465 25S rRNA binding site [nucleotide binding]; other site 93060002466 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 93060002467 RuvA N terminal domain; Region: RuvA_N; pfam01330 93060002468 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 93060002469 EamA-like transporter family; Region: EamA; pfam00892 93060002470 DNA primase; Validated; Region: dnaG; PRK05667 93060002471 CHC2 zinc finger; Region: zf-CHC2; pfam01807 93060002472 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 93060002473 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 93060002474 active site 93060002475 metal binding site [ion binding]; metal-binding site 93060002476 interdomain interaction site; other site 93060002477 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 93060002478 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 93060002479 active site 93060002480 DNA binding site [nucleotide binding] 93060002481 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 93060002482 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 93060002483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93060002484 Catalytic site [active] 93060002485 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 93060002486 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 93060002487 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 93060002488 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 93060002489 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 93060002490 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 93060002491 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 93060002492 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 93060002493 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 93060002494 alpha subunit interface [polypeptide binding]; other site 93060002495 TPP binding site [chemical binding]; other site 93060002496 heterodimer interface [polypeptide binding]; other site 93060002497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93060002498 protein-export membrane protein SecD; Region: secD; TIGR01129 93060002499 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 93060002500 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 93060002501 Protein export membrane protein; Region: SecD_SecF; cl14618 93060002502 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 93060002503 Domain of unknown function DUF20; Region: UPF0118; pfam01594 93060002504 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 93060002505 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 93060002506 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 93060002507 active site residue [active] 93060002508 GUN4-like; Region: GUN4; pfam05419 93060002509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 93060002510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 93060002511 ATP binding site [chemical binding]; other site 93060002512 Mg2+ binding site [ion binding]; other site 93060002513 G-X-G motif; other site 93060002514 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93060002515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060002516 S-adenosylmethionine binding site [chemical binding]; other site 93060002517 glutamine synthetase, type I; Region: GlnA; TIGR00653 93060002518 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 93060002519 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 93060002520 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 93060002521 homodimer interface [polypeptide binding]; other site 93060002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060002523 catalytic residue [active] 93060002524 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 93060002525 nucleoside/Zn binding site; other site 93060002526 dimer interface [polypeptide binding]; other site 93060002527 catalytic motif [active] 93060002528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060002529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060002530 catalytic residue [active] 93060002531 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 93060002532 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 93060002533 G1 box; other site 93060002534 GTP/Mg2+ binding site [chemical binding]; other site 93060002535 Switch I region; other site 93060002536 G2 box; other site 93060002537 Switch II region; other site 93060002538 G3 box; other site 93060002539 G4 box; other site 93060002540 G5 box; other site 93060002541 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93060002542 lipoprotein signal peptidase; Provisional; Region: PRK14792 93060002543 lipoprotein signal peptidase; Provisional; Region: PRK14787 93060002544 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 93060002545 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 93060002546 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 93060002547 FtsX-like permease family; Region: FtsX; pfam02687 93060002548 pyruvate kinase; Provisional; Region: PRK06354 93060002549 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 93060002550 domain interfaces; other site 93060002551 active site 93060002552 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 93060002553 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 93060002554 putative metal binding site [ion binding]; other site 93060002555 YGGT family; Region: YGGT; pfam02325 93060002556 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 93060002557 threonine dehydratase; Reviewed; Region: PRK09224 93060002558 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 93060002559 tetramer interface [polypeptide binding]; other site 93060002560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060002561 catalytic residue [active] 93060002562 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 93060002563 putative Ile/Val binding site [chemical binding]; other site 93060002564 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 93060002565 putative Ile/Val binding site [chemical binding]; other site 93060002566 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 93060002567 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 93060002568 TPP-binding site; other site 93060002569 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 93060002570 PYR/PP interface [polypeptide binding]; other site 93060002571 dimer interface [polypeptide binding]; other site 93060002572 TPP binding site [chemical binding]; other site 93060002573 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93060002574 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 93060002575 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 93060002576 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 93060002577 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 93060002578 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 93060002579 catalytic triad [active] 93060002580 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 93060002581 heat shock protein 90; Provisional; Region: PRK05218 93060002582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93060002583 ATP binding site [chemical binding]; other site 93060002584 Mg2+ binding site [ion binding]; other site 93060002585 G-X-G motif; other site 93060002586 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 93060002587 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 93060002588 motif 1; other site 93060002589 dimer interface [polypeptide binding]; other site 93060002590 active site 93060002591 motif 3; other site 93060002592 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 93060002593 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 93060002594 active site 93060002595 dimerization interface [polypeptide binding]; other site 93060002596 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93060002597 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93060002598 catalytic loop [active] 93060002599 iron binding site [ion binding]; other site 93060002600 molecular chaperone DnaK; Provisional; Region: PRK13410 93060002601 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 93060002602 nucleotide binding site [chemical binding]; other site 93060002603 chaperone protein DnaJ; Provisional; Region: PRK14299 93060002604 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93060002605 HSP70 interaction site [polypeptide binding]; other site 93060002606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 93060002607 substrate binding site [polypeptide binding]; other site 93060002608 dimer interface [polypeptide binding]; other site 93060002609 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 93060002610 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 93060002611 active site 93060002612 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 93060002613 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 93060002614 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 93060002615 dimerization interface [polypeptide binding]; other site 93060002616 active site 93060002617 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 93060002618 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 93060002619 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 93060002620 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 93060002621 active site 93060002622 substrate binding site [chemical binding]; other site 93060002623 cosubstrate binding site; other site 93060002624 catalytic site [active] 93060002625 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 93060002626 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 93060002627 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 93060002628 dimer interface [polypeptide binding]; other site 93060002629 active site 93060002630 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 93060002631 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 93060002632 HIGH motif; other site 93060002633 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93060002634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060002635 active site 93060002636 KMSKS motif; other site 93060002637 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 93060002638 tRNA binding surface [nucleotide binding]; other site 93060002639 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93060002640 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 93060002641 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 93060002642 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 93060002643 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060002644 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 93060002645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060002646 catalytic residue [active] 93060002647 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 93060002648 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 93060002649 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 93060002650 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 93060002651 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 93060002652 active site 93060002653 (T/H)XGH motif; other site 93060002654 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 93060002655 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 93060002656 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 93060002657 GIY-YIG motif/motif A; other site 93060002658 active site 93060002659 catalytic site [active] 93060002660 putative DNA binding site [nucleotide binding]; other site 93060002661 metal binding site [ion binding]; metal-binding site 93060002662 UvrB/uvrC motif; Region: UVR; pfam02151 93060002663 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 93060002664 Flavodoxin domain; Region: Flavodoxin_5; cl17428 93060002665 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 93060002666 PHP domain; Region: PHP; pfam02811 93060002667 active site 93060002668 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93060002669 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 93060002670 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93060002671 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 93060002672 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 93060002673 homodimer interface [polypeptide binding]; other site 93060002674 substrate-cofactor binding pocket; other site 93060002675 catalytic residue [active] 93060002676 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 93060002677 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 93060002678 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 93060002679 substrate binding pocket [chemical binding]; other site 93060002680 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 93060002681 B12 binding site [chemical binding]; other site 93060002682 cobalt ligand [ion binding]; other site 93060002683 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 93060002684 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 93060002685 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 93060002686 ATP adenylyltransferase; Region: ATP_transf; pfam09830 93060002687 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93060002688 HSP70 interaction site [polypeptide binding]; other site 93060002689 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 93060002690 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 93060002691 putative tRNA-binding site [nucleotide binding]; other site 93060002692 B3/4 domain; Region: B3_4; pfam03483 93060002693 tRNA synthetase B5 domain; Region: B5; smart00874 93060002694 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 93060002695 dimer interface [polypeptide binding]; other site 93060002696 motif 1; other site 93060002697 motif 3; other site 93060002698 motif 2; other site 93060002699 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 93060002700 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 93060002701 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 93060002702 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 93060002703 RNB domain; Region: RNB; pfam00773 93060002704 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 93060002705 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 93060002706 active site 93060002707 HIGH motif; other site 93060002708 KMSKS motif; other site 93060002709 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 93060002710 tRNA binding surface [nucleotide binding]; other site 93060002711 anticodon binding site; other site 93060002712 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 93060002713 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 93060002714 homotrimer interface [polypeptide binding]; other site 93060002715 Walker A motif; other site 93060002716 GTP binding site [chemical binding]; other site 93060002717 Walker B motif; other site 93060002718 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 93060002719 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 93060002720 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 93060002721 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 93060002722 dimer interface [polypeptide binding]; other site 93060002723 decamer (pentamer of dimers) interface [polypeptide binding]; other site 93060002724 catalytic triad [active] 93060002725 peroxidatic and resolving cysteines [active] 93060002726 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 93060002727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060002728 Walker A motif; other site 93060002729 ATP binding site [chemical binding]; other site 93060002730 Walker B motif; other site 93060002731 arginine finger; other site 93060002732 Peptidase family M41; Region: Peptidase_M41; pfam01434 93060002733 ribosomal protein L32; Validated; Region: rpl32; CHL00152 93060002734 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 93060002735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060002736 motif II; other site 93060002737 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 93060002738 similar to hypothetical protein 93060002739 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 93060002740 Predicted membrane protein [Function unknown]; Region: COG2119 93060002741 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 93060002742 Predicted membrane protein [Function unknown]; Region: COG2119 93060002743 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 93060002744 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 93060002745 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 93060002746 RNB domain; Region: RNB; pfam00773 93060002747 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 93060002748 RNA binding site [nucleotide binding]; other site 93060002749 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 93060002750 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 93060002751 diiron binding motif [ion binding]; other site 93060002752 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 93060002753 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 93060002754 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 93060002755 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 93060002756 putative active site [active] 93060002757 substrate binding site [chemical binding]; other site 93060002758 putative cosubstrate binding site; other site 93060002759 catalytic site [active] 93060002760 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 93060002761 substrate binding site [chemical binding]; other site 93060002762 Integral membrane protein TerC family; Region: TerC; cl10468 93060002763 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 93060002764 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 93060002765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060002766 ATP binding site [chemical binding]; other site 93060002767 putative Mg++ binding site [ion binding]; other site 93060002768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060002769 nucleotide binding region [chemical binding]; other site 93060002770 ATP-binding site [chemical binding]; other site 93060002771 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 93060002772 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 93060002773 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 93060002774 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 93060002775 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 93060002776 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 93060002777 dihydrodipicolinate reductase; Provisional; Region: PRK00048 93060002778 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 93060002779 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 93060002780 magnesium chelatase subunit H; Provisional; Region: PRK12493 93060002781 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 93060002782 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93060002783 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 93060002784 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 93060002785 dihydropteroate synthase; Region: DHPS; TIGR01496 93060002786 substrate binding pocket [chemical binding]; other site 93060002787 dimer interface [polypeptide binding]; other site 93060002788 inhibitor binding site; inhibition site 93060002789 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 93060002790 triosephosphate isomerase; Provisional; Region: PRK14565 93060002791 substrate binding site [chemical binding]; other site 93060002792 dimer interface [polypeptide binding]; other site 93060002793 catalytic triad [active] 93060002794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93060002795 RNA binding surface [nucleotide binding]; other site 93060002796 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 93060002797 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93060002798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060002799 Walker A/P-loop; other site 93060002800 ATP binding site [chemical binding]; other site 93060002801 Q-loop/lid; other site 93060002802 ABC transporter signature motif; other site 93060002803 Walker B; other site 93060002804 D-loop; other site 93060002805 H-loop/switch region; other site 93060002806 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 93060002807 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93060002808 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 93060002809 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 93060002810 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 93060002811 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93060002812 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 93060002813 IMP binding site; other site 93060002814 dimer interface [polypeptide binding]; other site 93060002815 interdomain contacts; other site 93060002816 partial ornithine binding site; other site 93060002817 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 93060002818 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 93060002819 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 93060002820 L-asparaginase II; Region: Asparaginase_II; pfam06089 93060002821 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93060002822 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 93060002823 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 93060002824 Walker A/P-loop; other site 93060002825 ATP binding site [chemical binding]; other site 93060002826 Q-loop/lid; other site 93060002827 ABC transporter signature motif; other site 93060002828 Walker B; other site 93060002829 D-loop; other site 93060002830 H-loop/switch region; other site 93060002831 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 93060002832 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 93060002833 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 93060002834 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 93060002835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93060002836 active site 93060002837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060002838 active site 93060002839 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 93060002840 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 93060002841 ski2-like helicase; Provisional; Region: PRK00254 93060002842 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 93060002843 AAA domain; Region: AAA_18; pfam13238 93060002844 active site 93060002845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93060002846 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 93060002847 active site pocket [active] 93060002848 oxyanion hole [active] 93060002849 catalytic triad [active] 93060002850 active site nucleophile [active] 93060002851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 93060002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93060002853 Coenzyme A binding pocket [chemical binding]; other site 93060002854 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93060002855 Protein of unknown function, DUF393; Region: DUF393; pfam04134 93060002856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93060002857 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 93060002858 aminopeptidase N; Provisional; Region: pepN; PRK14015 93060002859 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 93060002860 Zn binding site [ion binding]; other site 93060002861 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 93060002862 ATP-grasp domain; Region: ATP-grasp; pfam02222 93060002863 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 93060002864 catalytic residues [active] 93060002865 dimer interface [polypeptide binding]; other site 93060002866 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 93060002867 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 93060002868 FMN binding site [chemical binding]; other site 93060002869 active site 93060002870 catalytic residues [active] 93060002871 substrate binding site [chemical binding]; other site 93060002872 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 93060002873 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 93060002874 active site 93060002875 Restriction endonuclease; Region: Mrr_cat; pfam04471 93060002876 MAPEG family; Region: MAPEG; pfam01124 93060002877 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 93060002878 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 93060002879 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93060002880 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 93060002881 OsmC-like protein; Region: OsmC; pfam02566 93060002882 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 93060002883 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 93060002884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 93060002885 dimer interface [polypeptide binding]; other site 93060002886 putative PBP binding regions; other site 93060002887 ABC-ATPase subunit interface; other site 93060002888 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 93060002889 metal binding site 2 [ion binding]; metal-binding site 93060002890 putative DNA binding helix; other site 93060002891 metal binding site 1 [ion binding]; metal-binding site 93060002892 dimer interface [polypeptide binding]; other site 93060002893 structural Zn2+ binding site [ion binding]; other site 93060002894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 93060002895 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 93060002896 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 93060002897 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 93060002898 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 93060002899 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 93060002900 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 93060002901 P-loop, Walker A motif; other site 93060002902 Base recognition motif; other site 93060002903 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 93060002904 PQQ-like domain; Region: PQQ_2; pfam13360 93060002905 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 93060002906 structural tetrad; other site 93060002907 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 93060002908 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 93060002909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 93060002910 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 93060002911 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 93060002912 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 93060002913 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 93060002914 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 93060002915 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060002916 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060002917 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 93060002918 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93060002919 substrate binding site [chemical binding]; other site 93060002920 ATP binding site [chemical binding]; other site 93060002921 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 93060002922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93060002923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93060002924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93060002925 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 93060002926 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 93060002927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 93060002928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 93060002929 dimer interface [polypeptide binding]; other site 93060002930 conserved gate region; other site 93060002931 putative PBP binding loops; other site 93060002932 ABC-ATPase subunit interface; other site 93060002933 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 93060002934 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 93060002935 homoserine dehydrogenase; Provisional; Region: PRK06349 93060002936 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 93060002937 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 93060002938 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 93060002939 Fe-S metabolism associated domain; Region: SufE; cl00951 93060002940 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 93060002941 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 93060002942 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 93060002943 active site 93060002944 putative DNA-binding cleft [nucleotide binding]; other site 93060002945 dimer interface [polypeptide binding]; other site 93060002946 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 93060002947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 93060002948 Walker A motif; other site 93060002949 ATP binding site [chemical binding]; other site 93060002950 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 93060002951 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93060002952 Cytochrome c; Region: Cytochrom_C; pfam00034 93060002953 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 93060002954 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 93060002955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060002956 S-adenosylmethionine binding site [chemical binding]; other site 93060002957 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 93060002958 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 93060002959 putative active site [active] 93060002960 oxyanion strand; other site 93060002961 catalytic triad [active] 93060002962 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 93060002963 catalytic residues [active] 93060002964 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 93060002965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 93060002966 phosphate binding site [ion binding]; other site 93060002967 DNA gyrase subunit A; Validated; Region: PRK05560 93060002968 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 93060002969 CAP-like domain; other site 93060002970 active site 93060002971 primary dimer interface [polypeptide binding]; other site 93060002972 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002973 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002974 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002976 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 93060002978 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 93060002979 lycopene cyclase; Region: lycopene_cycl; TIGR01789 93060002980 Uncharacterized conserved protein [Function unknown]; Region: COG1543 93060002981 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 93060002982 active site 93060002983 substrate binding site [chemical binding]; other site 93060002984 catalytic site [active] 93060002985 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 93060002986 2-isopropylmalate synthase; Validated; Region: PRK00915 93060002987 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 93060002988 active site 93060002989 catalytic residues [active] 93060002990 metal binding site [ion binding]; metal-binding site 93060002991 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 93060002992 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 93060002993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 93060002994 Zn2+ binding site [ion binding]; other site 93060002995 Mg2+ binding site [ion binding]; other site 93060002996 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 93060002997 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 93060002998 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 93060002999 homodimer interface [polypeptide binding]; other site 93060003000 NADP binding site [chemical binding]; other site 93060003001 substrate binding site [chemical binding]; other site 93060003002 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 93060003003 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 93060003004 substrate binding pocket [chemical binding]; other site 93060003005 chain length determination region; other site 93060003006 substrate-Mg2+ binding site; other site 93060003007 catalytic residues [active] 93060003008 aspartate-rich region 1; other site 93060003009 active site lid residues [active] 93060003010 aspartate-rich region 2; other site 93060003011 Divergent PAP2 family; Region: DUF212; pfam02681 93060003012 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 93060003013 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060003014 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 93060003015 catalytic triad [active] 93060003016 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 93060003017 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 93060003018 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 93060003019 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 93060003020 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 93060003021 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 93060003022 dimerization interface [polypeptide binding]; other site 93060003023 FAD binding pocket [chemical binding]; other site 93060003024 FAD binding motif [chemical binding]; other site 93060003025 catalytic residues [active] 93060003026 NAD binding pocket [chemical binding]; other site 93060003027 phosphate binding motif [ion binding]; other site 93060003028 beta-alpha-beta structure motif; other site 93060003029 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 93060003030 hydrophobic ligand binding site; other site 93060003031 adaptive-response sensory kinase; Validated; Region: PRK09303 93060003032 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 93060003033 tetramer interface [polypeptide binding]; other site 93060003034 dimer interface [polypeptide binding]; other site 93060003035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93060003036 dimer interface [polypeptide binding]; other site 93060003037 phosphorylation site [posttranslational modification] 93060003038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93060003039 ATP binding site [chemical binding]; other site 93060003040 Mg2+ binding site [ion binding]; other site 93060003041 G-X-G motif; other site 93060003042 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 93060003043 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 93060003044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060003045 active site 93060003046 4-alpha-glucanotransferase; Provisional; Region: PRK14508 93060003047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 93060003048 non-specific DNA binding site [nucleotide binding]; other site 93060003049 salt bridge; other site 93060003050 sequence-specific DNA binding site [nucleotide binding]; other site 93060003051 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 93060003052 ABC1 family; Region: ABC1; cl17513 93060003053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060003054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060003055 catalytic residue [active] 93060003056 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 93060003057 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 93060003058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 93060003059 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 93060003060 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 93060003061 putative active site [active] 93060003062 metal binding site [ion binding]; metal-binding site 93060003063 Clp protease ATP binding subunit; Region: clpC; CHL00095 93060003064 Clp amino terminal domain; Region: Clp_N; pfam02861 93060003065 Clp amino terminal domain; Region: Clp_N; pfam02861 93060003066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060003067 Walker A motif; other site 93060003068 ATP binding site [chemical binding]; other site 93060003069 Walker B motif; other site 93060003070 arginine finger; other site 93060003071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060003072 Walker A motif; other site 93060003073 ATP binding site [chemical binding]; other site 93060003074 Walker B motif; other site 93060003075 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 93060003076 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 93060003077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 93060003078 diaminopimelate decarboxylase; Region: lysA; TIGR01048 93060003079 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 93060003080 active site 93060003081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93060003082 substrate binding site [chemical binding]; other site 93060003083 catalytic residues [active] 93060003084 dimer interface [polypeptide binding]; other site 93060003085 TIGR00159 family protein; Region: TIGR00159 93060003086 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 93060003087 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 93060003088 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 93060003089 catalytic residue [active] 93060003090 putative FPP diphosphate binding site; other site 93060003091 putative FPP binding hydrophobic cleft; other site 93060003092 dimer interface [polypeptide binding]; other site 93060003093 putative IPP diphosphate binding site; other site 93060003094 biotin synthase; Region: bioB; TIGR00433 93060003095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060003096 FeS/SAM binding site; other site 93060003097 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 93060003098 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 93060003099 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 93060003100 active site residue [active] 93060003101 lipoyl synthase; Provisional; Region: PRK12928 93060003102 recombination protein RecR; Reviewed; Region: recR; PRK00076 93060003103 RecR protein; Region: RecR; pfam02132 93060003104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 93060003105 putative active site [active] 93060003106 putative metal-binding site [ion binding]; other site 93060003107 tetramer interface [polypeptide binding]; other site 93060003108 PsbP; Region: PsbP; pfam01789 93060003109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93060003110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93060003111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060003112 Walker A/P-loop; other site 93060003113 ATP binding site [chemical binding]; other site 93060003114 Q-loop/lid; other site 93060003115 ABC transporter signature motif; other site 93060003116 Walker B; other site 93060003117 D-loop; other site 93060003118 H-loop/switch region; other site 93060003119 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 93060003120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 93060003121 ATP binding site [chemical binding]; other site 93060003122 Mg++ binding site [ion binding]; other site 93060003123 motif III; other site 93060003124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060003125 nucleotide binding region [chemical binding]; other site 93060003126 ATP-binding site [chemical binding]; other site 93060003127 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 93060003128 AAA domain; Region: AAA_30; pfam13604 93060003129 Family description; Region: UvrD_C_2; pfam13538 93060003130 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 93060003131 Family description; Region: UvrD_C_2; pfam13538 93060003132 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 93060003133 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 93060003134 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 93060003135 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 93060003136 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 93060003137 active site 93060003138 hydrophilic channel; other site 93060003139 dimerization interface [polypeptide binding]; other site 93060003140 catalytic residues [active] 93060003141 active site lid [active] 93060003142 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 93060003143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 93060003144 putative acyl-acceptor binding pocket; other site 93060003145 BolA-like protein; Region: BolA; pfam01722 93060003146 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 93060003147 putative GSH binding site [chemical binding]; other site 93060003148 catalytic residues [active] 93060003149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 93060003150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93060003151 active site 93060003152 intermolecular recognition site; other site 93060003153 dimerization interface [polypeptide binding]; other site 93060003154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93060003155 DNA binding site [nucleotide binding] 93060003156 carotene isomerase; Region: carot_isom; TIGR02730 93060003157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060003158 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 93060003159 Glucose inhibited division protein A; Region: GIDA; pfam01134 93060003160 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 93060003161 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 93060003162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060003163 TPR motif; other site 93060003164 binding surface 93060003165 Tetratricopeptide repeat; Region: TPR_16; pfam13432 93060003166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060003167 binding surface 93060003168 TPR motif; other site 93060003169 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 93060003170 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 93060003171 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 93060003172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060003173 active site 93060003174 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93060003175 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 93060003176 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 93060003177 Ligand binding site; other site 93060003178 Putative Catalytic site; other site 93060003179 DXD motif; other site 93060003180 GtrA-like protein; Region: GtrA; pfam04138 93060003181 Cupin domain; Region: Cupin_2; cl17218 93060003182 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 93060003183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060003184 active site 93060003185 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 93060003186 DNA protecting protein DprA; Region: dprA; TIGR00732 93060003187 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93060003188 L-aspartate oxidase; Provisional; Region: PRK06175 93060003189 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 93060003190 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 93060003191 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 93060003192 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 93060003193 protein binding site [polypeptide binding]; other site 93060003194 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 93060003195 active site 93060003196 catalytic residues [active] 93060003197 DNA binding site [nucleotide binding] 93060003198 Int/Topo IB signature motif; other site 93060003199 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 93060003200 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 93060003201 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 93060003202 putative high light inducible protein; Region: PHA02337 93060003203 putative high light inducible protein; Region: PHA02337 93060003204 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93060003205 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 93060003206 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93060003207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 93060003208 active site 93060003209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060003210 Tetratricopeptide repeat; Region: TPR_16; pfam13432 93060003211 TPR motif; other site 93060003212 binding surface 93060003213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 93060003214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060003215 binding surface 93060003216 TPR motif; other site 93060003217 Tetratricopeptide repeat; Region: TPR_16; pfam13432 93060003218 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 93060003219 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 93060003220 protein I interface; other site 93060003221 D2 interface; other site 93060003222 protein T interface; other site 93060003223 chlorophyll binding site; other site 93060003224 beta carotene binding site; other site 93060003225 pheophytin binding site; other site 93060003226 manganese-stabilizing polypeptide interface; other site 93060003227 CP43 interface; other site 93060003228 protein L interface; other site 93060003229 oxygen evolving complex binding site; other site 93060003230 bromide binding site; other site 93060003231 quinone binding site; other site 93060003232 Fe binding site [ion binding]; other site 93060003233 core light harvesting interface; other site 93060003234 cytochrome b559 alpha subunit interface; other site 93060003235 cytochrome c-550 interface; other site 93060003236 protein J interface; other site 93060003237 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 93060003238 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 93060003239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93060003240 RNA binding surface [nucleotide binding]; other site 93060003241 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 93060003242 probable active site [active] 93060003243 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 93060003244 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 93060003245 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 93060003246 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93060003247 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93060003248 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 93060003249 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 93060003250 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 93060003251 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 93060003252 Na2 binding site [ion binding]; other site 93060003253 putative substrate binding site 1 [chemical binding]; other site 93060003254 Na binding site 1 [ion binding]; other site 93060003255 putative substrate binding site 2 [chemical binding]; other site 93060003256 Uncharacterized conserved protein [Function unknown]; Region: COG0397 93060003257 hypothetical protein; Validated; Region: PRK00029 93060003258 putative high light inducible protein; Region: PHA02337 93060003259 putative high light inducible protein; Region: PHA02337 93060003260 putative high light inducible protein; Region: PHA02337 93060003261 GTP-binding protein YchF; Reviewed; Region: PRK09601 93060003262 YchF GTPase; Region: YchF; cd01900 93060003263 G1 box; other site 93060003264 GTP/Mg2+ binding site [chemical binding]; other site 93060003265 Switch I region; other site 93060003266 G2 box; other site 93060003267 Switch II region; other site 93060003268 G3 box; other site 93060003269 G4 box; other site 93060003270 G5 box; other site 93060003271 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 93060003272 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 93060003273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 93060003274 HlyD family secretion protein; Region: HlyD_3; pfam13437 93060003275 DNA polymerase I; Provisional; Region: PRK05755 93060003276 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 93060003277 active site 93060003278 metal binding site 1 [ion binding]; metal-binding site 93060003279 putative 5' ssDNA interaction site; other site 93060003280 metal binding site 3; metal-binding site 93060003281 metal binding site 2 [ion binding]; metal-binding site 93060003282 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 93060003283 putative DNA binding site [nucleotide binding]; other site 93060003284 putative metal binding site [ion binding]; other site 93060003285 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 93060003286 active site 93060003287 catalytic site [active] 93060003288 substrate binding site [chemical binding]; other site 93060003289 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 93060003290 active site 93060003291 DNA binding site [nucleotide binding] 93060003292 catalytic site [active] 93060003293 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 93060003294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060003295 active site 93060003296 HIGH motif; other site 93060003297 nucleotide binding site [chemical binding]; other site 93060003298 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 93060003299 KMSKS motif; other site 93060003300 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 93060003301 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 93060003302 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 93060003303 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 93060003304 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 93060003305 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 93060003306 FMN binding site [chemical binding]; other site 93060003307 dimer interface [polypeptide binding]; other site 93060003308 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 93060003309 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 93060003310 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 93060003311 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 93060003312 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 93060003313 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 93060003314 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 93060003315 ligand binding site [chemical binding]; other site 93060003316 homodimer interface [polypeptide binding]; other site 93060003317 NAD(P) binding site [chemical binding]; other site 93060003318 trimer interface B [polypeptide binding]; other site 93060003319 trimer interface A [polypeptide binding]; other site 93060003320 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 93060003321 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 93060003322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93060003323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93060003324 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 93060003325 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 93060003326 rRNA binding site [nucleotide binding]; other site 93060003327 predicted 30S ribosome binding site; other site 93060003328 Ycf39; Provisional; Region: ycf39; CHL00194 93060003329 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 93060003330 NAD(P) binding site [chemical binding]; other site 93060003331 putative active site [active] 93060003332 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 93060003333 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 93060003334 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 93060003335 putative valine binding site [chemical binding]; other site 93060003336 dimer interface [polypeptide binding]; other site 93060003337 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 93060003338 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 93060003339 active site 93060003340 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 93060003341 photosystem II protein D2; Region: psbD; CHL00004 93060003342 pheophytin binding site; other site 93060003343 chlorophyll binding site; other site 93060003344 quinone binding site; other site 93060003345 Fe binding site [ion binding]; other site 93060003346 Photosystem II protein; Region: PSII; cl08223 93060003347 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 93060003348 Maf-like protein; Region: Maf; pfam02545 93060003349 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 93060003350 active site 93060003351 dimer interface [polypeptide binding]; other site 93060003352 cobyric acid synthase; Provisional; Region: PRK00784 93060003353 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060003354 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 93060003355 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 93060003356 catalytic triad [active] 93060003357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93060003358 catalytic loop [active] 93060003359 iron binding site [ion binding]; other site 93060003360 Rhomboid family; Region: Rhomboid; cl11446 93060003361 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 93060003362 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 93060003363 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 93060003364 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 93060003365 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 93060003366 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 93060003367 dimer interface [polypeptide binding]; other site 93060003368 motif 1; other site 93060003369 active site 93060003370 motif 2; other site 93060003371 motif 3; other site 93060003372 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 93060003373 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 93060003374 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 93060003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 93060003376 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 93060003377 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 93060003378 flavodoxin FldA; Validated; Region: PRK09267 93060003379 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 93060003380 Uncharacterized conserved protein [Function unknown]; Region: COG4095 93060003381 Membrane transport protein; Region: Mem_trans; cl09117 93060003382 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 93060003383 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 93060003384 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060003385 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 93060003386 putative ADP-binding pocket [chemical binding]; other site 93060003387 EamA-like transporter family; Region: EamA; pfam00892 93060003388 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 93060003389 EamA-like transporter family; Region: EamA; pfam00892 93060003390 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 93060003391 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 93060003392 tandem repeat interface [polypeptide binding]; other site 93060003393 oligomer interface [polypeptide binding]; other site 93060003394 active site residues [active] 93060003395 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 93060003396 active site 93060003397 homotrimer interaction site [polypeptide binding]; other site 93060003398 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 93060003399 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 93060003400 Bacterial PH domain; Region: DUF304; pfam03703 93060003401 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 93060003402 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 93060003403 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 93060003404 Ycf46; Provisional; Region: ycf46; CHL00195 93060003405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060003406 Walker A motif; other site 93060003407 ATP binding site [chemical binding]; other site 93060003408 Walker B motif; other site 93060003409 arginine finger; other site 93060003410 seryl-tRNA synthetase; Provisional; Region: PRK05431 93060003411 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 93060003412 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 93060003413 dimer interface [polypeptide binding]; other site 93060003414 active site 93060003415 motif 1; other site 93060003416 motif 2; other site 93060003417 motif 3; other site 93060003418 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 93060003419 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 93060003420 active site 93060003421 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 93060003422 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 93060003423 putative substrate binding region [chemical binding]; other site 93060003424 ribosomal protein S14; Region: rps14; CHL00074 93060003425 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 93060003426 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 93060003427 RNase E interface [polypeptide binding]; other site 93060003428 trimer interface [polypeptide binding]; other site 93060003429 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 93060003430 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 93060003431 RNase E interface [polypeptide binding]; other site 93060003432 trimer interface [polypeptide binding]; other site 93060003433 active site 93060003434 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 93060003435 putative nucleic acid binding region [nucleotide binding]; other site 93060003436 G-X-X-G motif; other site 93060003437 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 93060003438 RNA binding site [nucleotide binding]; other site 93060003439 domain interface; other site 93060003440 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 93060003441 active site 93060003442 Predicted methyltransferases [General function prediction only]; Region: COG0313 93060003443 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 93060003444 putative SAM binding site [chemical binding]; other site 93060003445 putative homodimer interface [polypeptide binding]; other site 93060003446 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 93060003447 O-Antigen ligase; Region: Wzy_C; pfam04932 93060003448 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 93060003449 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 93060003450 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 93060003451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060003452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060003453 NAD(P) binding site [chemical binding]; other site 93060003454 active site 93060003455 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 93060003456 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 93060003457 NAD binding site [chemical binding]; other site 93060003458 homodimer interface [polypeptide binding]; other site 93060003459 active site 93060003460 substrate binding site [chemical binding]; other site 93060003461 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 93060003462 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 93060003463 NADP-binding site; other site 93060003464 homotetramer interface [polypeptide binding]; other site 93060003465 substrate binding site [chemical binding]; other site 93060003466 homodimer interface [polypeptide binding]; other site 93060003467 active site 93060003468 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 93060003469 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 93060003470 Substrate binding site; other site 93060003471 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 93060003472 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 93060003473 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 93060003474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060003475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060003476 catalytic residue [active] 93060003477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93060003478 active site 93060003479 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 93060003480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060003481 motif II; other site 93060003482 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 93060003483 Ligand binding site; other site 93060003484 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 93060003485 catalytic site [active] 93060003486 active site 93060003487 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 93060003488 active site 93060003489 domain interfaces; other site 93060003490 Bacterial sugar transferase; Region: Bac_transf; pfam02397 93060003491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 93060003492 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 93060003493 Walker A/P-loop; other site 93060003494 ATP binding site [chemical binding]; other site 93060003495 Q-loop/lid; other site 93060003496 ABC transporter signature motif; other site 93060003497 Walker B; other site 93060003498 D-loop; other site 93060003499 H-loop/switch region; other site 93060003500 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 93060003501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060003502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 93060003503 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 93060003504 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 93060003505 NADP binding site [chemical binding]; other site 93060003506 active site 93060003507 putative substrate binding site [chemical binding]; other site 93060003508 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 93060003509 dimerization interface [polypeptide binding]; other site 93060003510 putative active cleft [active] 93060003511 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 93060003512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060003513 active site 93060003514 motif I; other site 93060003515 motif II; other site 93060003516 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93060003517 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 93060003518 Substrate binding site; other site 93060003519 Mg++ binding site; other site 93060003520 metal-binding site 93060003521 Mg++ binding site; other site 93060003522 metal-binding site 93060003523 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 93060003524 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 93060003525 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 93060003526 NADP-binding site; other site 93060003527 homotetramer interface [polypeptide binding]; other site 93060003528 substrate binding site [chemical binding]; other site 93060003529 homodimer interface [polypeptide binding]; other site 93060003530 active site 93060003531 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 93060003532 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93060003533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060003534 S-adenosylmethionine binding site [chemical binding]; other site 93060003535 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 93060003536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060003537 NAD(P) binding site [chemical binding]; other site 93060003538 active site 93060003539 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060003540 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 93060003541 nudix motif; other site 93060003542 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 93060003543 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 93060003544 substrate binding site; other site 93060003545 tetramer interface; other site 93060003546 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 93060003547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060003548 NAD(P) binding site [chemical binding]; other site 93060003549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 93060003550 FOG: CBS domain [General function prediction only]; Region: COG0517 93060003551 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 93060003552 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 93060003553 Substrate binding site; other site 93060003554 metal-binding site 93060003555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93060003556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93060003557 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 93060003558 ligand binding site; other site 93060003559 tetramer interface; other site 93060003560 flagellin modification protein A; Provisional; Region: PRK09186 93060003561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060003562 NAD(P) binding site [chemical binding]; other site 93060003563 active site 93060003564 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 93060003565 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 93060003566 NAD binding site [chemical binding]; other site 93060003567 substrate binding site [chemical binding]; other site 93060003568 active site 93060003569 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 93060003570 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 93060003571 inhibitor-cofactor binding pocket; inhibition site 93060003572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060003573 catalytic residue [active] 93060003574 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 93060003575 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 93060003576 active site 93060003577 homodimer interface [polypeptide binding]; other site 93060003578 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 93060003579 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 93060003580 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 93060003581 NADP binding site [chemical binding]; other site 93060003582 active site 93060003583 putative substrate binding site [chemical binding]; other site 93060003584 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 93060003585 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 93060003586 NAD binding site [chemical binding]; other site 93060003587 substrate binding site [chemical binding]; other site 93060003588 homodimer interface [polypeptide binding]; other site 93060003589 active site 93060003590 Bacterial sugar transferase; Region: Bac_transf; cl00939 93060003591 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 93060003592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 93060003593 active site 93060003594 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 93060003595 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93060003596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060003597 S-adenosylmethionine binding site [chemical binding]; other site 93060003598 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 93060003599 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060003600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060003601 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 93060003602 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 93060003603 ligand binding site; other site 93060003604 tetramer interface; other site 93060003605 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 93060003606 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 93060003607 NAD binding site [chemical binding]; other site 93060003608 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 93060003609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 93060003610 NeuB family; Region: NeuB; pfam03102 93060003611 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 93060003612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93060003613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 93060003614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 93060003615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 93060003616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060003617 Walker A/P-loop; other site 93060003618 ATP binding site [chemical binding]; other site 93060003619 Q-loop/lid; other site 93060003620 ABC transporter signature motif; other site 93060003621 Walker B; other site 93060003622 D-loop; other site 93060003623 H-loop/switch region; other site 93060003624 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 93060003625 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 93060003626 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 93060003627 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060003628 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 93060003629 putative NAD(P) binding site [chemical binding]; other site 93060003630 active site 93060003631 putative substrate binding site [chemical binding]; other site 93060003632 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93060003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060003634 Methyltransferase domain; Region: Methyltransf_23; pfam13489 93060003635 Methyltransferase domain; Region: Methyltransf_12; pfam08242 93060003636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060003637 active site 93060003638 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 93060003639 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 93060003640 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 93060003641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060003642 FeS/SAM binding site; other site 93060003643 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 93060003644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 93060003645 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 93060003646 active site 93060003647 dimer interface [polypeptide binding]; other site 93060003648 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 93060003649 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 93060003650 Ligand Binding Site [chemical binding]; other site 93060003651 Molecular Tunnel; other site 93060003652 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 93060003653 NeuB family; Region: NeuB; pfam03102 93060003654 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 93060003655 NeuB binding interface [polypeptide binding]; other site 93060003656 putative substrate binding site [chemical binding]; other site 93060003657 Phosphopantetheine attachment site; Region: PP-binding; cl09936 93060003658 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 93060003659 active site 93060003660 dimer interface [polypeptide binding]; other site 93060003661 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 93060003662 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 93060003663 Ligand Binding Site [chemical binding]; other site 93060003664 Molecular Tunnel; other site 93060003665 Glutamine amidotransferase domain; Region: GATase_7; pfam13537 93060003666 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 93060003667 Ligand Binding Site [chemical binding]; other site 93060003668 Molecular Tunnel; other site 93060003669 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 93060003670 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 93060003671 putative trimer interface [polypeptide binding]; other site 93060003672 putative CoA binding site [chemical binding]; other site 93060003673 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 93060003674 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 93060003675 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 93060003676 Catalytic site [active] 93060003677 ornithine carbamoyltransferase; Provisional; Region: PRK00779 93060003678 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 93060003679 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 93060003680 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 93060003681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060003682 Walker A motif; other site 93060003683 ATP binding site [chemical binding]; other site 93060003684 Walker B motif; other site 93060003685 arginine finger; other site 93060003686 Peptidase family M41; Region: Peptidase_M41; pfam01434 93060003687 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 93060003688 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 93060003689 catalytic motif [active] 93060003690 Zn binding site [ion binding]; other site 93060003691 RibD C-terminal domain; Region: RibD_C; cl17279 93060003692 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 93060003693 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 93060003694 active site 93060003695 SAM binding site [chemical binding]; other site 93060003696 putative homodimer interface [polypeptide binding]; other site 93060003697 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 93060003698 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 93060003699 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 93060003700 ATP-NAD kinase; Region: NAD_kinase; pfam01513 93060003701 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 93060003702 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 93060003703 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 93060003704 dimer interface [polypeptide binding]; other site 93060003705 motif 1; other site 93060003706 active site 93060003707 motif 2; other site 93060003708 motif 3; other site 93060003709 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 93060003710 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 93060003711 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 93060003712 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 93060003713 active site 93060003714 Riboflavin kinase; Region: Flavokinase; smart00904 93060003715 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 93060003716 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 93060003717 thiamine phosphate binding site [chemical binding]; other site 93060003718 active site 93060003719 pyrophosphate binding site [ion binding]; other site 93060003720 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 93060003721 thiS-thiF/thiG interaction site; other site 93060003722 AIR carboxylase; Region: AIRC; smart01001 93060003723 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 93060003724 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 93060003725 homotrimer interaction site [polypeptide binding]; other site 93060003726 zinc binding site [ion binding]; other site 93060003727 CDP-binding sites; other site 93060003728 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 93060003729 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93060003730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 93060003731 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 93060003732 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 93060003733 SLBB domain; Region: SLBB; pfam10531 93060003734 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 93060003735 GTPase Era; Reviewed; Region: era; PRK00089 93060003736 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 93060003737 G1 box; other site 93060003738 GTP/Mg2+ binding site [chemical binding]; other site 93060003739 Switch I region; other site 93060003740 G2 box; other site 93060003741 Switch II region; other site 93060003742 G3 box; other site 93060003743 G4 box; other site 93060003744 G5 box; other site 93060003745 KH domain; Region: KH_2; pfam07650 93060003746 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 93060003747 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 93060003748 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 93060003749 PhoH-like protein; Region: PhoH; pfam02562 93060003750 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 93060003751 signal recognition particle protein; Provisional; Region: PRK10867 93060003752 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 93060003753 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 93060003754 P loop; other site 93060003755 GTP binding site [chemical binding]; other site 93060003756 Signal peptide binding domain; Region: SRP_SPB; pfam02978 93060003757 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 93060003758 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 93060003759 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 93060003760 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 93060003761 tetramer interface [polypeptide binding]; other site 93060003762 TPP-binding site [chemical binding]; other site 93060003763 heterodimer interface [polypeptide binding]; other site 93060003764 phosphorylation loop region [posttranslational modification] 93060003765 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93060003766 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93060003767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93060003768 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93060003769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93060003770 DNA binding residues [nucleotide binding] 93060003771 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 93060003772 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 93060003773 putative substrate binding site [chemical binding]; other site 93060003774 putative ATP binding site [chemical binding]; other site 93060003775 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 93060003776 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 93060003777 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 93060003778 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 93060003779 putative active site [active] 93060003780 catalytic triad [active] 93060003781 putative dimer interface [polypeptide binding]; other site 93060003782 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 93060003783 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 93060003784 superoxide dismutase, Ni; Region: sodN; TIGR02753 93060003785 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 93060003786 Catalytic site [active] 93060003787 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 93060003788 active site 93060003789 ribulose/triose binding site [chemical binding]; other site 93060003790 phosphate binding site [ion binding]; other site 93060003791 substrate (anthranilate) binding pocket [chemical binding]; other site 93060003792 product (indole) binding pocket [chemical binding]; other site 93060003793 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 93060003794 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 93060003795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 93060003796 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 93060003797 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 93060003798 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 93060003799 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 93060003800 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 93060003801 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 93060003802 hinge; other site 93060003803 active site 93060003804 acetylornithine aminotransferase; Provisional; Region: PRK02627 93060003805 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93060003806 inhibitor-cofactor binding pocket; inhibition site 93060003807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060003808 catalytic residue [active] 93060003809 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 93060003810 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 93060003811 FAD binding domain; Region: FAD_binding_4; pfam01565 93060003812 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 93060003813 Amidohydrolase; Region: Amidohydro_4; pfam13147 93060003814 active site 93060003815 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 93060003816 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 93060003817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060003818 FeS/SAM binding site; other site 93060003819 TRAM domain; Region: TRAM; cl01282 93060003820 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 93060003821 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 93060003822 ATP-grasp domain; Region: ATP-grasp_4; cl17255 93060003823 cell division protein FtsZ; Validated; Region: PRK09330 93060003824 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 93060003825 nucleotide binding site [chemical binding]; other site 93060003826 SulA interaction site; other site 93060003827 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 93060003828 oligomerization interface [polypeptide binding]; other site 93060003829 active site 93060003830 metal binding site [ion binding]; metal-binding site 93060003831 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 93060003832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060003833 FeS/SAM binding site; other site 93060003834 HemN C-terminal domain; Region: HemN_C; pfam06969 93060003835 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 93060003836 putative active site [active] 93060003837 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 93060003838 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93060003839 oligomer interface [polypeptide binding]; other site 93060003840 active site residues [active] 93060003841 Clp protease; Region: CLP_protease; pfam00574 93060003842 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93060003843 oligomer interface [polypeptide binding]; other site 93060003844 active site residues [active] 93060003845 ketol-acid reductoisomerase; Provisional; Region: PRK05479 93060003846 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 93060003847 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 93060003848 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 93060003849 light-harvesting-like protein 3; Provisional; Region: PLN00014 93060003850 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 93060003851 IHF dimer interface [polypeptide binding]; other site 93060003852 IHF - DNA interface [nucleotide binding]; other site 93060003853 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 93060003854 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 93060003855 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 93060003856 active site 93060003857 catalytic site [active] 93060003858 MFS/sugar transport protein; Region: MFS_2; pfam13347 93060003859 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 93060003860 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 93060003861 Permease; Region: Permease; pfam02405 93060003862 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 93060003863 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 93060003864 membrane protein; Provisional; Region: PRK14419 93060003865 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 93060003866 active site 93060003867 dimer interface [polypeptide binding]; other site 93060003868 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 93060003869 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 93060003870 active site 93060003871 HIGH motif; other site 93060003872 dimer interface [polypeptide binding]; other site 93060003873 KMSKS motif; other site 93060003874 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 93060003875 multifunctional aminopeptidase A; Provisional; Region: PRK00913 93060003876 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 93060003877 interface (dimer of trimers) [polypeptide binding]; other site 93060003878 Substrate-binding/catalytic site; other site 93060003879 Zn-binding sites [ion binding]; other site 93060003880 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 93060003881 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 93060003882 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 93060003883 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 93060003884 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 93060003885 active site 93060003886 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 93060003887 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 93060003888 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 93060003889 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 93060003890 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 93060003891 Surface antigen; Region: Bac_surface_Ag; pfam01103 93060003892 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 93060003893 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 93060003894 ATP binding site [chemical binding]; other site 93060003895 active site 93060003896 substrate binding site [chemical binding]; other site 93060003897 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 93060003898 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 93060003899 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 93060003900 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 93060003901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 93060003902 dimerization interface [polypeptide binding]; other site 93060003903 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 93060003904 PAS domain; Region: PAS; smart00091 93060003905 putative active site [active] 93060003906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93060003907 dimer interface [polypeptide binding]; other site 93060003908 phosphorylation site [posttranslational modification] 93060003909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93060003910 ATP binding site [chemical binding]; other site 93060003911 Mg2+ binding site [ion binding]; other site 93060003912 G-X-G motif; other site 93060003913 circadian clock protein KaiC; Reviewed; Region: PRK09302 93060003914 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 93060003915 Walker A motif; other site 93060003916 ATP binding site [chemical binding]; other site 93060003917 Walker B motif; other site 93060003918 recA bacterial DNA recombination protein; Region: RecA; cl17211 93060003919 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 93060003920 Walker A motif; other site 93060003921 ATP binding site [chemical binding]; other site 93060003922 Walker B motif; other site 93060003923 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 93060003924 tetramer interface [polypeptide binding]; other site 93060003925 dimer interface [polypeptide binding]; other site 93060003926 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 93060003927 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 93060003928 Methyltransferase domain; Region: Methyltransf_12; pfam08242 93060003929 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 93060003930 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 93060003931 RNA binding site [nucleotide binding]; other site 93060003932 active site 93060003933 Stage II sporulation protein; Region: SpoIID; pfam08486 93060003934 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 93060003935 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 93060003936 ribonuclease Z; Region: RNase_Z; TIGR02651 93060003937 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 93060003938 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 93060003939 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 93060003940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93060003941 catalytic loop [active] 93060003942 iron binding site [ion binding]; other site 93060003943 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 93060003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060003945 S-adenosylmethionine binding site [chemical binding]; other site 93060003946 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 93060003947 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 93060003948 ligand binding site [chemical binding]; other site 93060003949 NAD binding site [chemical binding]; other site 93060003950 dimerization interface [polypeptide binding]; other site 93060003951 catalytic site [active] 93060003952 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 93060003953 putative L-serine binding site [chemical binding]; other site 93060003954 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 93060003955 Phospholipid methyltransferase; Region: PEMT; cl17370 93060003956 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 93060003957 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 93060003958 DoxX; Region: DoxX; pfam07681 93060003959 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 93060003960 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 93060003961 nucleotide binding pocket [chemical binding]; other site 93060003962 K-X-D-G motif; other site 93060003963 catalytic site [active] 93060003964 short chain dehydrogenase; Provisional; Region: PRK06197 93060003965 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 93060003966 putative NAD(P) binding site [chemical binding]; other site 93060003967 active site 93060003968 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 93060003969 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 93060003970 Pirin-related protein [General function prediction only]; Region: COG1741 93060003971 Pirin; Region: Pirin; pfam02678 93060003972 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 93060003973 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 93060003974 GAF domain; Region: GAF; pfam01590 93060003975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 93060003976 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 93060003977 flavoprotein, HI0933 family; Region: TIGR00275 93060003978 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 93060003979 Protein of unknown function (DUF805); Region: DUF805; pfam05656 93060003980 Fatty acid desaturase; Region: FA_desaturase; pfam00487 93060003981 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 93060003982 putative di-iron ligands [ion binding]; other site 93060003983 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 93060003984 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 93060003985 Fatty acid desaturase; Region: FA_desaturase; pfam00487 93060003986 putative di-iron ligands [ion binding]; other site 93060003987 putative high light inducible protein; Region: PHA02337 93060003988 putative high light inducible protein; Region: PHA02337 93060003989 putative high light inducible protein; Region: PHA02337 93060003990 Predicted permeases [General function prediction only]; Region: COG0795 93060003991 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 93060003992 DoxX; Region: DoxX; cl17842 93060003993 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 93060003994 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 93060003995 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 93060003996 putative active site [active] 93060003997 PhoH-like protein; Region: PhoH; pfam02562 93060003998 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 93060003999 putative high light inducible protein; Region: PHA02337 93060004000 putative high light inducible protein; Region: PHA02337 93060004001 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 93060004002 Cupin domain; Region: Cupin_2; pfam07883 93060004003 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 93060004004 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 93060004005 Predicted membrane protein [Function unknown]; Region: COG4244 93060004006 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 93060004007 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 93060004008 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 93060004009 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 93060004010 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 93060004011 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 93060004012 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 93060004013 Subunit I/III interface [polypeptide binding]; other site 93060004014 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 93060004015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 93060004016 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 93060004017 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 93060004018 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 93060004019 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 93060004020 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 93060004021 catalytic triad [active] 93060004022 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 93060004023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 93060004024 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 93060004025 EVE domain; Region: EVE; cl00728 93060004026 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 93060004027 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 93060004028 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 93060004029 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 93060004030 nucleotide binding site [chemical binding]; other site 93060004031 putative NEF/HSP70 interaction site [polypeptide binding]; other site 93060004032 SBD interface [polypeptide binding]; other site 93060004033 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 93060004034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 93060004035 active site 93060004036 phosphoglyceromutase; Provisional; Region: PRK05434 93060004037 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 93060004038 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 93060004039 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 93060004040 ring oligomerisation interface [polypeptide binding]; other site 93060004041 ATP/Mg binding site [chemical binding]; other site 93060004042 stacking interactions; other site 93060004043 hinge regions; other site 93060004044 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 93060004045 oligomerisation interface [polypeptide binding]; other site 93060004046 mobile loop; other site 93060004047 roof hairpin; other site 93060004048 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 93060004049 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93060004050 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 93060004051 alpha subunit interaction interface [polypeptide binding]; other site 93060004052 Walker A motif; other site 93060004053 ATP binding site [chemical binding]; other site 93060004054 Walker B motif; other site 93060004055 inhibitor binding site; inhibition site 93060004056 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93060004057 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 93060004058 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 93060004059 gamma subunit interface [polypeptide binding]; other site 93060004060 epsilon subunit interface [polypeptide binding]; other site 93060004061 LBP interface [polypeptide binding]; other site 93060004062 hypothetical protein; Provisional; Region: PRK02724 93060004063 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 93060004064 proline aminopeptidase P II; Provisional; Region: PRK10879 93060004065 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 93060004066 active site 93060004067 Domain of unknown function DUF21; Region: DUF21; pfam01595 93060004068 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 93060004069 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 93060004070 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 93060004071 G1 box; other site 93060004072 GTP/Mg2+ binding site [chemical binding]; other site 93060004073 Switch I region; other site 93060004074 G2 box; other site 93060004075 Switch II region; other site 93060004076 G3 box; other site 93060004077 G4 box; other site 93060004078 G5 box; other site 93060004079 Domain of unknown function (DUF697); Region: DUF697; pfam05128 93060004080 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 93060004081 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 93060004082 active site 93060004083 (T/H)XGH motif; other site 93060004084 NAD synthetase; Provisional; Region: PRK13981 93060004085 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 93060004086 multimer interface [polypeptide binding]; other site 93060004087 active site 93060004088 catalytic triad [active] 93060004089 protein interface 1 [polypeptide binding]; other site 93060004090 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 93060004091 homodimer interface [polypeptide binding]; other site 93060004092 NAD binding pocket [chemical binding]; other site 93060004093 ATP binding pocket [chemical binding]; other site 93060004094 Mg binding site [ion binding]; other site 93060004095 active-site loop [active] 93060004096 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 93060004097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 93060004098 catalytic loop [active] 93060004099 iron binding site [ion binding]; other site 93060004100 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 93060004101 core domain interface [polypeptide binding]; other site 93060004102 delta subunit interface [polypeptide binding]; other site 93060004103 epsilon subunit interface [polypeptide binding]; other site 93060004104 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 93060004105 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 93060004106 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 93060004107 beta subunit interaction interface [polypeptide binding]; other site 93060004108 Walker A motif; other site 93060004109 ATP binding site [chemical binding]; other site 93060004110 Walker B motif; other site 93060004111 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 93060004112 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 93060004113 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 93060004114 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 93060004115 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 93060004116 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 93060004117 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 93060004118 ATP synthase CF0 C subunit; Region: atpH; CHL00061 93060004119 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 93060004120 ATP synthase CF0 A subunit; Region: atpI; CHL00046 93060004121 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 93060004122 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 93060004123 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 93060004124 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 93060004125 ResB-like family; Region: ResB; pfam05140 93060004126 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 93060004127 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 93060004128 Nitrogen regulatory protein P-II; Region: P-II; smart00938 93060004129 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 93060004130 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 93060004131 RNA binding surface [nucleotide binding]; other site 93060004132 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 93060004133 adenylosuccinate lyase; Provisional; Region: PRK07380 93060004134 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 93060004135 tetramer interface [polypeptide binding]; other site 93060004136 active site 93060004137 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 93060004138 fumarate hydratase; Reviewed; Region: fumC; PRK00485 93060004139 Class II fumarases; Region: Fumarase_classII; cd01362 93060004140 active site 93060004141 tetramer interface [polypeptide binding]; other site 93060004142 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 93060004143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060004144 ATP binding site [chemical binding]; other site 93060004145 putative Mg++ binding site [ion binding]; other site 93060004146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060004147 nucleotide binding region [chemical binding]; other site 93060004148 ATP-binding site [chemical binding]; other site 93060004149 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 93060004150 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 93060004151 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 93060004152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060004153 catalytic residue [active] 93060004154 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 93060004155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060004156 S-adenosylmethionine binding site [chemical binding]; other site 93060004157 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 93060004158 AAA domain; Region: AAA_26; pfam13500 93060004159 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 93060004160 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 93060004161 inhibitor-cofactor binding pocket; inhibition site 93060004162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060004163 catalytic residue [active] 93060004164 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 93060004165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 93060004166 HSP70 interaction site [polypeptide binding]; other site 93060004167 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 93060004168 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 93060004169 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 93060004170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 93060004171 active site 93060004172 catalytic tetrad [active] 93060004173 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 93060004174 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 93060004175 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 93060004176 HEAT repeats; Region: HEAT_2; pfam13646 93060004177 HEAT repeats; Region: HEAT_2; pfam13646 93060004178 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 93060004179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060004180 FeS/SAM binding site; other site 93060004181 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 93060004182 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 93060004183 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 93060004184 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 93060004185 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 93060004186 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 93060004187 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 93060004188 DNA binding site [nucleotide binding] 93060004189 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 93060004190 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 93060004191 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 93060004192 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 93060004193 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 93060004194 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 93060004195 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 93060004196 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 93060004197 RPB1 interaction site [polypeptide binding]; other site 93060004198 RPB10 interaction site [polypeptide binding]; other site 93060004199 RPB11 interaction site [polypeptide binding]; other site 93060004200 RPB3 interaction site [polypeptide binding]; other site 93060004201 RPB12 interaction site [polypeptide binding]; other site 93060004202 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 93060004203 active site 93060004204 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 93060004205 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 93060004206 histidinol dehydrogenase; Region: hisD; TIGR00069 93060004207 NAD binding site [chemical binding]; other site 93060004208 dimerization interface [polypeptide binding]; other site 93060004209 product binding site; other site 93060004210 substrate binding site [chemical binding]; other site 93060004211 zinc binding site [ion binding]; other site 93060004212 catalytic residues [active] 93060004213 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 93060004214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93060004215 active site 93060004216 dimer interface [polypeptide binding]; other site 93060004217 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 93060004218 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 93060004219 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 93060004220 protein binding site [polypeptide binding]; other site 93060004221 ribosome maturation protein RimP; Reviewed; Region: PRK00092 93060004222 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 93060004223 putative oligomer interface [polypeptide binding]; other site 93060004224 putative RNA binding site [nucleotide binding]; other site 93060004225 NusA N-terminal domain; Region: NusA_N; pfam08529 93060004226 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 93060004227 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 93060004228 RNA binding site [nucleotide binding]; other site 93060004229 homodimer interface [polypeptide binding]; other site 93060004230 NusA-like KH domain; Region: KH_5; pfam13184 93060004231 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 93060004232 G-X-X-G motif; other site 93060004233 translation initiation factor IF-2; Region: IF-2; TIGR00487 93060004234 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 93060004235 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 93060004236 G1 box; other site 93060004237 putative GEF interaction site [polypeptide binding]; other site 93060004238 GTP/Mg2+ binding site [chemical binding]; other site 93060004239 Switch I region; other site 93060004240 G2 box; other site 93060004241 G3 box; other site 93060004242 Switch II region; other site 93060004243 G4 box; other site 93060004244 G5 box; other site 93060004245 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 93060004246 Translation-initiation factor 2; Region: IF-2; pfam11987 93060004247 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 93060004248 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 93060004249 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 93060004250 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 93060004251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060004252 FeS/SAM binding site; other site 93060004253 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 93060004254 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 93060004255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 93060004256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060004257 homodimer interface [polypeptide binding]; other site 93060004258 catalytic residue [active] 93060004259 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 93060004260 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 93060004261 homodimer interface [polypeptide binding]; other site 93060004262 oligonucleotide binding site [chemical binding]; other site 93060004263 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 93060004264 RNA/DNA hybrid binding site [nucleotide binding]; other site 93060004265 active site 93060004266 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 93060004267 prephenate dehydratase; Provisional; Region: PRK11898 93060004268 Prephenate dehydratase; Region: PDT; pfam00800 93060004269 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 93060004270 putative L-Phe binding site [chemical binding]; other site 93060004271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 93060004272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060004273 S-adenosylmethionine binding site [chemical binding]; other site 93060004274 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 93060004275 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 93060004276 elongation factor Tu; Reviewed; Region: PRK00049 93060004277 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 93060004278 G1 box; other site 93060004279 GEF interaction site [polypeptide binding]; other site 93060004280 GTP/Mg2+ binding site [chemical binding]; other site 93060004281 Switch I region; other site 93060004282 G2 box; other site 93060004283 G3 box; other site 93060004284 Switch II region; other site 93060004285 G4 box; other site 93060004286 G5 box; other site 93060004287 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 93060004288 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 93060004289 Antibiotic Binding Site [chemical binding]; other site 93060004290 elongation factor G; Reviewed; Region: PRK00007 93060004291 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 93060004292 G1 box; other site 93060004293 putative GEF interaction site [polypeptide binding]; other site 93060004294 GTP/Mg2+ binding site [chemical binding]; other site 93060004295 Switch I region; other site 93060004296 G2 box; other site 93060004297 G3 box; other site 93060004298 Switch II region; other site 93060004299 G4 box; other site 93060004300 G5 box; other site 93060004301 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 93060004302 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 93060004303 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 93060004304 30S ribosomal protein S7; Validated; Region: PRK05302 93060004305 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 93060004306 S17 interaction site [polypeptide binding]; other site 93060004307 S8 interaction site; other site 93060004308 16S rRNA interaction site [nucleotide binding]; other site 93060004309 streptomycin interaction site [chemical binding]; other site 93060004310 23S rRNA interaction site [nucleotide binding]; other site 93060004311 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 93060004312 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 93060004313 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 93060004314 active site 93060004315 dimer interface [polypeptide binding]; other site 93060004316 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 93060004317 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 93060004318 active site 93060004319 FMN binding site [chemical binding]; other site 93060004320 substrate binding site [chemical binding]; other site 93060004321 3Fe-4S cluster binding site [ion binding]; other site 93060004322 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 93060004323 domain interface; other site 93060004324 lipoyl synthase; Provisional; Region: PRK05481 93060004325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 93060004326 FeS/SAM binding site; other site 93060004327 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 93060004328 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 93060004329 catalytic residues [active] 93060004330 Presynaptic Site I dimer interface [polypeptide binding]; other site 93060004331 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 93060004332 Synaptic Flat tetramer interface [polypeptide binding]; other site 93060004333 Synaptic Site I dimer interface [polypeptide binding]; other site 93060004334 DNA binding site [nucleotide binding] 93060004335 Trp repressor protein; Region: Trp_repressor; cl17266 93060004336 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 93060004337 NlpC/P60 family; Region: NLPC_P60; pfam00877 93060004338 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 93060004339 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 93060004340 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 93060004341 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 93060004342 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 93060004343 Ligand binding site; other site 93060004344 Putative Catalytic site; other site 93060004345 DXD motif; other site 93060004346 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 93060004347 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 93060004348 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 93060004349 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 93060004350 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 93060004351 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 93060004352 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 93060004353 active site 93060004354 SAM binding site [chemical binding]; other site 93060004355 homodimer interface [polypeptide binding]; other site 93060004356 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93060004357 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 93060004358 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 93060004359 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 93060004360 alanine racemase; Reviewed; Region: alr; PRK00053 93060004361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 93060004362 active site 93060004363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 93060004364 dimer interface [polypeptide binding]; other site 93060004365 substrate binding site [chemical binding]; other site 93060004366 catalytic residues [active] 93060004367 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 93060004368 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 93060004369 active site 93060004370 peptide chain release factor 1; Validated; Region: prfA; PRK00591 93060004371 This domain is found in peptide chain release factors; Region: PCRF; smart00937 93060004372 RF-1 domain; Region: RF-1; pfam00472 93060004373 ribosomal protein L31; Validated; Region: rpl31; CHL00136 93060004374 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 93060004375 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 93060004376 23S rRNA interface [nucleotide binding]; other site 93060004377 L3 interface [polypeptide binding]; other site 93060004378 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 93060004379 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 93060004380 dimerization interface 3.5A [polypeptide binding]; other site 93060004381 active site 93060004382 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 93060004383 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 93060004384 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 93060004385 alphaNTD homodimer interface [polypeptide binding]; other site 93060004386 alphaNTD - beta interaction site [polypeptide binding]; other site 93060004387 alphaNTD - beta' interaction site [polypeptide binding]; other site 93060004388 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 93060004389 30S ribosomal protein S11; Validated; Region: PRK05309 93060004390 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 93060004391 30S ribosomal protein S13; Region: bact_S13; TIGR03631 93060004392 adenylate kinase; Provisional; Region: PRK14531 93060004393 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 93060004394 AMP-binding site [chemical binding]; other site 93060004395 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 93060004396 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 93060004397 SecY translocase; Region: SecY; pfam00344 93060004398 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 93060004399 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 93060004400 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 93060004401 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 93060004402 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 93060004403 5S rRNA interface [nucleotide binding]; other site 93060004404 L27 interface [polypeptide binding]; other site 93060004405 23S rRNA interface [nucleotide binding]; other site 93060004406 L5 interface [polypeptide binding]; other site 93060004407 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 93060004408 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93060004409 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 93060004410 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 93060004411 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 93060004412 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 93060004413 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 93060004414 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 93060004415 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 93060004416 RNA binding site [nucleotide binding]; other site 93060004417 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 93060004418 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 93060004419 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 93060004420 23S rRNA interface [nucleotide binding]; other site 93060004421 putative translocon interaction site; other site 93060004422 signal recognition particle (SRP54) interaction site; other site 93060004423 L23 interface [polypeptide binding]; other site 93060004424 trigger factor interaction site; other site 93060004425 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 93060004426 23S rRNA interface [nucleotide binding]; other site 93060004427 5S rRNA interface [nucleotide binding]; other site 93060004428 putative antibiotic binding site [chemical binding]; other site 93060004429 L25 interface [polypeptide binding]; other site 93060004430 L27 interface [polypeptide binding]; other site 93060004431 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 93060004432 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 93060004433 G-X-X-G motif; other site 93060004434 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 93060004435 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 93060004436 putative translocon binding site; other site 93060004437 protein-rRNA interface [nucleotide binding]; other site 93060004438 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 93060004439 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 93060004440 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 93060004441 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 93060004442 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 93060004443 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 93060004444 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 93060004445 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 93060004446 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 93060004447 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 93060004448 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 93060004449 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 93060004450 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 93060004451 recombinase A; Provisional; Region: recA; PRK09354 93060004452 hexamer interface [polypeptide binding]; other site 93060004453 Walker A motif; other site 93060004454 ATP binding site [chemical binding]; other site 93060004455 Walker B motif; other site 93060004456 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 93060004457 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 93060004458 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 93060004459 arogenate dehydrogenase; Reviewed; Region: PRK07417 93060004460 prephenate dehydrogenase; Validated; Region: PRK08507 93060004461 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 93060004462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 93060004463 Fructosamine kinase; Region: Fructosamin_kin; cl17579 93060004464 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 93060004465 hypothetical protein; Validated; Region: PRK07411 93060004466 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 93060004467 ATP binding site [chemical binding]; other site 93060004468 substrate interface [chemical binding]; other site 93060004469 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 93060004470 active site residue [active] 93060004471 hypothetical protein; Validated; Region: PRK07413 93060004472 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 93060004473 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 93060004474 Walker A motif; other site 93060004475 homodimer interface [polypeptide binding]; other site 93060004476 ATP binding site [chemical binding]; other site 93060004477 hydroxycobalamin binding site [chemical binding]; other site 93060004478 Walker B motif; other site 93060004479 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 93060004480 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 93060004481 Ligand Binding Site [chemical binding]; other site 93060004482 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 93060004483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060004484 recombination protein F; Reviewed; Region: recF; PRK00064 93060004485 Q-loop/lid; other site 93060004486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060004487 ABC transporter signature motif; other site 93060004488 Walker B; other site 93060004489 D-loop; other site 93060004490 H-loop/switch region; other site 93060004491 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 93060004492 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 93060004493 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 93060004494 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 93060004495 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 93060004496 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93060004497 PsaD; Region: PsaD; pfam02531 93060004498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 93060004499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 93060004500 dimer interface [polypeptide binding]; other site 93060004501 phosphorylation site [posttranslational modification] 93060004502 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 93060004503 Domain of unknown function DUF59; Region: DUF59; pfam01883 93060004504 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 93060004505 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 93060004506 Walker A motif; other site 93060004507 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 93060004508 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 93060004509 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 93060004510 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 93060004511 catalytic site [active] 93060004512 putative active site [active] 93060004513 putative substrate binding site [chemical binding]; other site 93060004514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 93060004515 conserved hypothetical protein; Region: TIGR03492 93060004516 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 93060004517 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 93060004518 dimerization interface [polypeptide binding]; other site 93060004519 putative ATP binding site [chemical binding]; other site 93060004520 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 93060004521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060004522 active site 93060004523 nucleotide binding site [chemical binding]; other site 93060004524 HIGH motif; other site 93060004525 KMSKS motif; other site 93060004526 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 93060004527 active site 93060004528 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 93060004529 CMP-binding site; other site 93060004530 The sites determining sugar specificity; other site 93060004531 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 93060004532 Low molecular weight phosphatase family; Region: LMWPc; cd00115 93060004533 active site 93060004534 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 93060004535 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 93060004536 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 93060004537 heme binding pocket [chemical binding]; other site 93060004538 heme ligand [chemical binding]; other site 93060004539 isocitrate dehydrogenase; Validated; Region: PRK07362 93060004540 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 93060004541 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 93060004542 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 93060004543 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 93060004544 active site 93060004545 catalytic residues [active] 93060004546 hydrolase, alpha/beta fold family protein; Region: PLN02824 93060004547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 93060004548 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 93060004549 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 93060004550 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 93060004551 homodimer interface [polypeptide binding]; other site 93060004552 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 93060004553 active site pocket [active] 93060004554 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 93060004555 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 93060004556 dimerization interface [polypeptide binding]; other site 93060004557 active site 93060004558 metal binding site [ion binding]; metal-binding site 93060004559 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 93060004560 dsRNA binding site [nucleotide binding]; other site 93060004561 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 93060004562 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 93060004563 RimM N-terminal domain; Region: RimM; pfam01782 93060004564 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 93060004565 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 93060004566 glutaminase active site [active] 93060004567 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 93060004568 dimer interface [polypeptide binding]; other site 93060004569 active site 93060004570 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 93060004571 dimer interface [polypeptide binding]; other site 93060004572 active site 93060004573 photosystem I subunit VII; Region: psaC; CHL00065 93060004574 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 93060004575 acyl carrier protein; Provisional; Region: acpP; PRK00982 93060004576 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 93060004577 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 93060004578 dimer interface [polypeptide binding]; other site 93060004579 active site 93060004580 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 93060004581 transketolase; Region: PLN02790 93060004582 TPP-binding site [chemical binding]; other site 93060004583 dimer interface [polypeptide binding]; other site 93060004584 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 93060004585 PYR/PP interface [polypeptide binding]; other site 93060004586 dimer interface [polypeptide binding]; other site 93060004587 TPP binding site [chemical binding]; other site 93060004588 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 93060004589 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 93060004590 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 93060004591 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 93060004592 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 93060004593 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 93060004594 metal binding site [ion binding]; metal-binding site 93060004595 dimer interface [polypeptide binding]; other site 93060004596 TPR repeat; Region: TPR_11; pfam13414 93060004597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060004598 binding surface 93060004599 TPR motif; other site 93060004600 TPR repeat; Region: TPR_11; pfam13414 93060004601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060004602 binding surface 93060004603 Tetratricopeptide repeat; Region: TPR_16; pfam13432 93060004604 TPR motif; other site 93060004605 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 93060004606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060004607 Walker A motif; other site 93060004608 ATP binding site [chemical binding]; other site 93060004609 Walker B motif; other site 93060004610 arginine finger; other site 93060004611 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 93060004612 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 93060004613 SmpB-tmRNA interface; other site 93060004614 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 93060004615 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 93060004616 dimer interface [polypeptide binding]; other site 93060004617 putative anticodon binding site; other site 93060004618 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 93060004619 motif 1; other site 93060004620 active site 93060004621 motif 2; other site 93060004622 motif 3; other site 93060004623 Ycf27; Reviewed; Region: orf27; CHL00148 93060004624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 93060004625 active site 93060004626 phosphorylation site [posttranslational modification] 93060004627 intermolecular recognition site; other site 93060004628 dimerization interface [polypeptide binding]; other site 93060004629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 93060004630 DNA binding site [nucleotide binding] 93060004631 rod shape-determining protein MreC; Provisional; Region: PRK13922 93060004632 rod shape-determining protein MreC; Region: MreC; pfam04085 93060004633 rod shape-determining protein MreB; Provisional; Region: PRK13927 93060004634 MreB and similar proteins; Region: MreB_like; cd10225 93060004635 nucleotide binding site [chemical binding]; other site 93060004636 Mg binding site [ion binding]; other site 93060004637 putative protofilament interaction site [polypeptide binding]; other site 93060004638 RodZ interaction site [polypeptide binding]; other site 93060004639 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 93060004640 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 93060004641 dimer interface [polypeptide binding]; other site 93060004642 ssDNA binding site [nucleotide binding]; other site 93060004643 tetramer (dimer of dimers) interface [polypeptide binding]; other site 93060004644 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 93060004645 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93060004646 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 93060004647 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 93060004648 homotetramer interface [polypeptide binding]; other site 93060004649 ligand binding site [chemical binding]; other site 93060004650 catalytic site [active] 93060004651 NAD binding site [chemical binding]; other site 93060004652 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 93060004653 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 93060004654 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 93060004655 putative substrate binding site [chemical binding]; other site 93060004656 putative ATP binding site [chemical binding]; other site 93060004657 hydrolase, alpha/beta fold family protein; Region: PLN02824 93060004658 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93060004659 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93060004660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93060004661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93060004662 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 93060004663 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 93060004664 MgtE intracellular N domain; Region: MgtE_N; smart00924 93060004665 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 93060004666 Divalent cation transporter; Region: MgtE; pfam01769 93060004667 CrcB-like protein; Region: CRCB; pfam02537 93060004668 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 93060004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 93060004670 ATP binding site [chemical binding]; other site 93060004671 Mg2+ binding site [ion binding]; other site 93060004672 G-X-G motif; other site 93060004673 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 93060004674 anchoring element; other site 93060004675 dimer interface [polypeptide binding]; other site 93060004676 ATP binding site [chemical binding]; other site 93060004677 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 93060004678 active site 93060004679 putative metal-binding site [ion binding]; other site 93060004680 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 93060004681 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 93060004682 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 93060004683 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 93060004684 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 93060004685 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 93060004686 Predicted transcriptional regulators [Transcription]; Region: COG1725 93060004687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 93060004688 DNA-binding site [nucleotide binding]; DNA binding site 93060004689 serine O-acetyltransferase; Region: cysE; TIGR01172 93060004690 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 93060004691 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 93060004692 trimer interface [polypeptide binding]; other site 93060004693 active site 93060004694 substrate binding site [chemical binding]; other site 93060004695 CoA binding site [chemical binding]; other site 93060004696 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 93060004697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060004698 ATP binding site [chemical binding]; other site 93060004699 putative Mg++ binding site [ion binding]; other site 93060004700 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 93060004701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 93060004702 Coenzyme A binding pocket [chemical binding]; other site 93060004703 SnoaL-like domain; Region: SnoaL_2; pfam12680 93060004704 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 93060004705 homopentamer interface [polypeptide binding]; other site 93060004706 active site 93060004707 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 93060004708 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 93060004709 MutS domain I; Region: MutS_I; pfam01624 93060004710 MutS domain II; Region: MutS_II; pfam05188 93060004711 MutS domain III; Region: MutS_III; pfam05192 93060004712 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 93060004713 Walker A/P-loop; other site 93060004714 ATP binding site [chemical binding]; other site 93060004715 Q-loop/lid; other site 93060004716 ABC transporter signature motif; other site 93060004717 Walker B; other site 93060004718 D-loop; other site 93060004719 H-loop/switch region; other site 93060004720 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 93060004721 Precorrin-8X methylmutase; Region: CbiC; pfam02570 93060004722 DNA polymerase III subunit delta; Validated; Region: PRK07452 93060004723 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 93060004724 aspartate kinase; Provisional; Region: PRK07431 93060004725 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 93060004726 putative nucleotide binding site [chemical binding]; other site 93060004727 putative catalytic residues [active] 93060004728 putative Mg ion binding site [ion binding]; other site 93060004729 putative aspartate binding site [chemical binding]; other site 93060004730 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 93060004731 putative allosteric regulatory site; other site 93060004732 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 93060004733 putative allosteric regulatory residue; other site 93060004734 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 93060004735 putative allosteric regulatory site; other site 93060004736 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 93060004737 putative allosteric regulatory residue; other site 93060004738 excinuclease ABC subunit B; Provisional; Region: PRK05298 93060004739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 93060004740 ATP binding site [chemical binding]; other site 93060004741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 93060004742 nucleotide binding region [chemical binding]; other site 93060004743 ATP-binding site [chemical binding]; other site 93060004744 Ultra-violet resistance protein B; Region: UvrB; pfam12344 93060004745 UvrB/uvrC motif; Region: UVR; pfam02151 93060004746 Protein of unknown function (DUF561); Region: DUF561; pfam04481 93060004747 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 93060004748 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 93060004749 Ligand Binding Site [chemical binding]; other site 93060004750 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 93060004751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 93060004752 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 93060004753 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 93060004754 dihydrodipicolinate synthase; Region: dapA; TIGR00674 93060004755 dimer interface [polypeptide binding]; other site 93060004756 active site 93060004757 catalytic residue [active] 93060004758 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 93060004759 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 93060004760 trigger factor; Region: tig; TIGR00115 93060004761 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 93060004762 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 93060004763 Clp protease; Region: CLP_protease; pfam00574 93060004764 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 93060004765 oligomer interface [polypeptide binding]; other site 93060004766 active site residues [active] 93060004767 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 93060004768 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 93060004769 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 93060004770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060004771 Walker A motif; other site 93060004772 ATP binding site [chemical binding]; other site 93060004773 Walker B motif; other site 93060004774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 93060004775 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 93060004776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 93060004777 Walker A motif; other site 93060004778 ATP binding site [chemical binding]; other site 93060004779 Walker B motif; other site 93060004780 arginine finger; other site 93060004781 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 93060004782 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 93060004783 DXD motif; other site 93060004784 Sporulation related domain; Region: SPOR; cl10051 93060004785 Stage II sporulation protein; Region: SpoIID; pfam08486 93060004786 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 93060004787 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 93060004788 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 93060004789 23S rRNA binding site [nucleotide binding]; other site 93060004790 L21 binding site [polypeptide binding]; other site 93060004791 L13 binding site [polypeptide binding]; other site 93060004792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 93060004793 binding surface 93060004794 TPR motif; other site 93060004795 TPR repeat; Region: TPR_11; pfam13414 93060004796 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 93060004797 ThiS interaction site; other site 93060004798 putative active site [active] 93060004799 tetramer interface [polypeptide binding]; other site 93060004800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 93060004801 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 93060004802 NAD(P) binding site [chemical binding]; other site 93060004803 active site 93060004804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 93060004805 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 93060004806 glycine dehydrogenase; Provisional; Region: PRK05367 93060004807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 93060004808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 93060004809 catalytic residue [active] 93060004810 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 93060004811 tetramer interface [polypeptide binding]; other site 93060004812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060004813 catalytic residue [active] 93060004814 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 93060004815 lipoyl attachment site [posttranslational modification]; other site 93060004816 Aluminium resistance protein; Region: Alum_res; pfam06838 93060004817 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 93060004818 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 93060004819 Fatty acid desaturase; Region: FA_desaturase; pfam00487 93060004820 Di-iron ligands [ion binding]; other site 93060004821 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 93060004822 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 93060004823 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 93060004824 replicative DNA helicase; Region: DnaB; TIGR00665 93060004825 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 93060004826 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 93060004827 Walker A motif; other site 93060004828 ATP binding site [chemical binding]; other site 93060004829 Walker B motif; other site 93060004830 DNA binding loops [nucleotide binding] 93060004831 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 93060004832 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 93060004833 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 93060004834 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 93060004835 Protein of unknown function (DUF98); Region: DUF98; pfam01947 93060004836 SprT-like family; Region: SprT-like; pfam10263 93060004837 SprT homologues; Region: SprT; cl01182 93060004838 DNA ligase; Provisional; Region: 30; PHA02587 93060004839 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 93060004840 active site 93060004841 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 93060004842 DNA binding site [nucleotide binding] 93060004843 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 93060004844 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 93060004845 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 93060004846 active site 93060004847 HIGH motif; other site 93060004848 nucleotide binding site [chemical binding]; other site 93060004849 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 93060004850 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 93060004851 active site 93060004852 KMSKS motif; other site 93060004853 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 93060004854 tRNA binding surface [nucleotide binding]; other site 93060004855 anticodon binding site; other site 93060004856 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 93060004857 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 93060004858 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 93060004859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 93060004860 homodimer interface [polypeptide binding]; other site 93060004861 metal binding site [ion binding]; metal-binding site 93060004862 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 93060004863 homodimer interface [polypeptide binding]; other site 93060004864 active site 93060004865 putative chemical substrate binding site [chemical binding]; other site 93060004866 metal binding site [ion binding]; metal-binding site 93060004867 spermidine synthase; Provisional; Region: PRK00811 93060004868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 93060004869 S-adenosylmethionine binding site [chemical binding]; other site 93060004870 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 93060004871 agmatinase; Region: agmatinase; TIGR01230 93060004872 putative active site [active] 93060004873 Mn binding site [ion binding]; other site 93060004874 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 93060004875 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 93060004876 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 93060004877 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 93060004878 dimer interface [polypeptide binding]; other site 93060004879 anticodon binding site; other site 93060004880 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 93060004881 homodimer interface [polypeptide binding]; other site 93060004882 motif 1; other site 93060004883 active site 93060004884 motif 2; other site 93060004885 GAD domain; Region: GAD; pfam02938 93060004886 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 93060004887 active site 93060004888 motif 3; other site 93060004889 CTP synthetase; Validated; Region: pyrG; PRK05380 93060004890 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 93060004891 Catalytic site [active] 93060004892 active site 93060004893 UTP binding site [chemical binding]; other site 93060004894 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 93060004895 active site 93060004896 putative oxyanion hole; other site 93060004897 catalytic triad [active] 93060004898 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 93060004899 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 93060004900 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 93060004901 Ligand Binding Site [chemical binding]; other site 93060004902 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 93060004903 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 93060004904 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 93060004905 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 93060004906 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 93060004907 homodimer interface [polypeptide binding]; other site 93060004908 substrate-cofactor binding pocket; other site 93060004909 Aminotransferase class IV; Region: Aminotran_4; pfam01063 93060004910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060004911 catalytic residue [active] 93060004912 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 93060004913 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 93060004914 active site 93060004915 SAM binding site [chemical binding]; other site 93060004916 homodimer interface [polypeptide binding]; other site 93060004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 93060004918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 93060004919 putative substrate translocation pore; other site 93060004920 polyphosphate kinase; Provisional; Region: PRK05443 93060004921 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 93060004922 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 93060004923 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 93060004924 putative domain interface [polypeptide binding]; other site 93060004925 putative active site [active] 93060004926 catalytic site [active] 93060004927 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 93060004928 putative domain interface [polypeptide binding]; other site 93060004929 putative active site [active] 93060004930 catalytic site [active] 93060004931 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 93060004932 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 93060004933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 93060004934 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 93060004935 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 93060004936 DNA binding residues [nucleotide binding] 93060004937 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 93060004938 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 93060004939 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 93060004940 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 93060004941 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 93060004942 substrate binding site [chemical binding]; other site 93060004943 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 93060004944 substrate binding site [chemical binding]; other site 93060004945 ligand binding site [chemical binding]; other site 93060004946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 93060004947 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 93060004948 Cl- selectivity filter; other site 93060004949 Cl- binding residues [ion binding]; other site 93060004950 pore gating glutamate residue; other site 93060004951 dimer interface [polypeptide binding]; other site 93060004952 H+/Cl- coupling transport residue; other site 93060004953 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 93060004954 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 93060004955 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 93060004956 putative active site [active] 93060004957 putative substrate binding site [chemical binding]; other site 93060004958 putative cosubstrate binding site; other site 93060004959 catalytic site [active] 93060004960 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 93060004961 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 93060004962 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 93060004963 nucleotide binding site [chemical binding]; other site 93060004964 NEF interaction site [polypeptide binding]; other site 93060004965 SBD interface [polypeptide binding]; other site 93060004966 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 93060004967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 93060004968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 93060004969 shikimate binding site; other site 93060004970 NAD(P) binding site [chemical binding]; other site 93060004971 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 93060004972 argininosuccinate synthase; Provisional; Region: PRK13820 93060004973 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 93060004974 ANP binding site [chemical binding]; other site 93060004975 Substrate Binding Site II [chemical binding]; other site 93060004976 Substrate Binding Site I [chemical binding]; other site 93060004977 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 93060004978 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 93060004979 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 93060004980 Mg++ binding site [ion binding]; other site 93060004981 putative catalytic motif [active] 93060004982 putative substrate binding site [chemical binding]; other site 93060004983 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 93060004984 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 93060004985 putative ADP-binding pocket [chemical binding]; other site 93060004986 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 93060004987 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93060004988 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 93060004989 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 93060004990 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 93060004991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 93060004992 Walker A/P-loop; other site 93060004993 ATP binding site [chemical binding]; other site 93060004994 Q-loop/lid; other site 93060004995 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 93060004996 ABC transporter signature motif; other site 93060004997 Walker B; other site 93060004998 D-loop; other site 93060004999 H-loop/switch region; other site 93060005000 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 93060005001 ABC1 family; Region: ABC1; cl17513 93060005002 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 93060005003 threonine synthase; Reviewed; Region: PRK06721 93060005004 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 93060005005 homodimer interface [polypeptide binding]; other site 93060005006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 93060005007 catalytic residue [active]