-- dump date 20140620_000141 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167546000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167546000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167546000003 putative DNA binding surface [nucleotide binding]; other site 167546000004 dimer interface [polypeptide binding]; other site 167546000005 beta-clamp/clamp loader binding surface; other site 167546000006 beta-clamp/translesion DNA polymerase binding surface; other site 167546000007 PRC-barrel domain; Region: PRC; pfam05239 167546000008 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167546000009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167546000010 dimerization interface [polypeptide binding]; other site 167546000011 ATP binding site [chemical binding]; other site 167546000012 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167546000013 dimerization interface [polypeptide binding]; other site 167546000014 ATP binding site [chemical binding]; other site 167546000015 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167546000016 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167546000017 active site 167546000018 tetramer interface [polypeptide binding]; other site 167546000019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546000020 active site 167546000021 DNA Topoisomerase IV; Region: TOP4c; smart00434 167546000022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167546000023 CAP-like domain; other site 167546000024 active site 167546000025 primary dimer interface [polypeptide binding]; other site 167546000026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000027 binding surface 167546000028 TPR motif; other site 167546000029 TPR repeat; Region: TPR_11; pfam13414 167546000030 TPR repeat; Region: TPR_11; pfam13414 167546000031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000032 binding surface 167546000033 TPR motif; other site 167546000034 TPR repeat; Region: TPR_11; pfam13414 167546000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 167546000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167546000037 Uncharacterized conserved protein [Function unknown]; Region: COG2928 167546000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 167546000039 putative RNA binding site [nucleotide binding]; other site 167546000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167546000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 167546000042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167546000043 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 167546000044 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 167546000045 argininosuccinate lyase; Provisional; Region: PRK00855 167546000046 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167546000047 active sites [active] 167546000048 tetramer interface [polypeptide binding]; other site 167546000049 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167546000050 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167546000051 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 167546000052 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167546000053 FMN binding site [chemical binding]; other site 167546000054 active site 167546000055 catalytic residues [active] 167546000056 substrate binding site [chemical binding]; other site 167546000057 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 167546000058 SelR domain; Region: SelR; pfam01641 167546000059 GrpE; Region: GrpE; pfam01025 167546000060 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167546000061 dimer interface [polypeptide binding]; other site 167546000062 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167546000063 chaperone protein DnaJ; Provisional; Region: PRK14293 167546000064 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167546000065 HSP70 interaction site [polypeptide binding]; other site 167546000066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 167546000067 substrate binding site [polypeptide binding]; other site 167546000068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167546000069 Zn binding sites [ion binding]; other site 167546000070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167546000071 dimer interface [polypeptide binding]; other site 167546000072 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167546000073 CPxP motif; other site 167546000074 Predicted GTPases [General function prediction only]; Region: COG1162 167546000075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167546000076 RNA binding site [nucleotide binding]; other site 167546000077 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 167546000078 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167546000079 GTP/Mg2+ binding site [chemical binding]; other site 167546000080 G4 box; other site 167546000081 G5 box; other site 167546000082 G1 box; other site 167546000083 Switch I region; other site 167546000084 G2 box; other site 167546000085 G3 box; other site 167546000086 Switch II region; other site 167546000087 hypothetical protein; Validated; Region: PRK00153 167546000088 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167546000089 FAD binding domain; Region: FAD_binding_4; pfam01565 167546000090 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167546000091 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167546000092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167546000093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167546000094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167546000095 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167546000096 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167546000097 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167546000098 thiamine monophosphate kinase; Provisional; Region: PRK05731 167546000099 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167546000100 ATP binding site [chemical binding]; other site 167546000101 dimerization interface [polypeptide binding]; other site 167546000102 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167546000103 active site 167546000104 elongation factor P; Validated; Region: PRK00529 167546000105 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167546000106 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167546000107 RNA binding site [nucleotide binding]; other site 167546000108 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167546000109 RNA binding site [nucleotide binding]; other site 167546000110 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167546000111 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167546000112 carboxyltransferase (CT) interaction site; other site 167546000113 biotinylation site [posttranslational modification]; other site 167546000114 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 167546000115 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 167546000116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167546000117 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 167546000118 putative NAD(P) binding site [chemical binding]; other site 167546000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167546000120 active site 167546000121 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167546000122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167546000123 homodimer interface [polypeptide binding]; other site 167546000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000125 catalytic residue [active] 167546000126 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 167546000127 GMP synthase; Reviewed; Region: guaA; PRK00074 167546000128 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167546000129 AMP/PPi binding site [chemical binding]; other site 167546000130 candidate oxyanion hole; other site 167546000131 catalytic triad [active] 167546000132 potential glutamine specificity residues [chemical binding]; other site 167546000133 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167546000134 ATP Binding subdomain [chemical binding]; other site 167546000135 Ligand Binding sites [chemical binding]; other site 167546000136 Dimerization subdomain; other site 167546000137 TPR repeat; Region: TPR_11; pfam13414 167546000138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000139 binding surface 167546000140 TPR motif; other site 167546000141 TPR repeat; Region: TPR_11; pfam13414 167546000142 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 167546000143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000144 binding surface 167546000145 TPR repeat; Region: TPR_11; pfam13414 167546000146 TPR motif; other site 167546000147 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167546000148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167546000149 binding surface 167546000150 TPR motif; other site 167546000151 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 167546000152 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167546000153 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167546000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167546000155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167546000156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 167546000157 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167546000158 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167546000159 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167546000160 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167546000161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167546000162 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167546000163 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167546000164 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 167546000165 motif 1; other site 167546000166 active site 167546000167 motif 2; other site 167546000168 motif 3; other site 167546000169 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167546000170 DHHA1 domain; Region: DHHA1; pfam02272 167546000171 arginine decarboxylase; Provisional; Region: PRK05354 167546000172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167546000173 dimer interface [polypeptide binding]; other site 167546000174 active site 167546000175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167546000176 catalytic residues [active] 167546000177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167546000178 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167546000179 active site 167546000180 multimer interface [polypeptide binding]; other site 167546000181 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 167546000182 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167546000183 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167546000184 GatB domain; Region: GatB_Yqey; smart00845 167546000185 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167546000186 dephospho-CoA kinase; Region: TIGR00152 167546000187 CoA-binding site [chemical binding]; other site 167546000188 ATP-binding [chemical binding]; other site 167546000189 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167546000190 heterotetramer interface [polypeptide binding]; other site 167546000191 active site pocket [active] 167546000192 cleavage site 167546000193 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 167546000194 DEAD-like helicases superfamily; Region: DEXDc; smart00487 167546000195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 167546000196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546000197 ATP binding site [chemical binding]; other site 167546000198 putative Mg++ binding site [ion binding]; other site 167546000199 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 167546000200 nucleotide binding region [chemical binding]; other site 167546000201 ATP-binding site [chemical binding]; other site 167546000202 Helicase associated domain; Region: HA; pfam03457 167546000203 Helicase associated domain; Region: HA; pfam03457 167546000204 Helicase associated domain; Region: HA; pfam03457 167546000205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000206 TPR motif; other site 167546000207 binding surface 167546000208 TPR repeat; Region: TPR_11; pfam13414 167546000209 ParA-like protein; Provisional; Region: PHA02518 167546000210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 167546000211 P-loop; other site 167546000212 Magnesium ion binding site [ion binding]; other site 167546000213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167546000214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 167546000215 active site 167546000216 catalytic tetrad [active] 167546000217 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167546000218 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 167546000219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167546000220 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 167546000221 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 167546000222 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167546000223 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167546000224 Walker A/P-loop; other site 167546000225 ATP binding site [chemical binding]; other site 167546000226 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 167546000227 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167546000228 ABC transporter signature motif; other site 167546000229 Walker B; other site 167546000230 D-loop; other site 167546000231 H-loop/switch region; other site 167546000232 PRC-barrel domain; Region: PRC; pfam05239 167546000233 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 167546000234 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167546000235 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167546000236 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167546000237 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 167546000238 YGGT family; Region: YGGT; pfam02325 167546000239 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 167546000240 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167546000241 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 167546000242 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 167546000243 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 167546000244 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 167546000245 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167546000246 nucleotide binding site/active site [active] 167546000247 HIT family signature motif; other site 167546000248 catalytic residue [active] 167546000249 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167546000250 active site 167546000251 catalytic residues [active] 167546000252 metal binding site [ion binding]; metal-binding site 167546000253 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 167546000254 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 167546000255 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167546000256 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167546000257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546000258 catalytic residue [active] 167546000259 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 167546000260 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 167546000261 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167546000262 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 167546000263 Walker A/P-loop; other site 167546000264 ATP binding site [chemical binding]; other site 167546000265 Q-loop/lid; other site 167546000266 ABC transporter signature motif; other site 167546000267 Walker B; other site 167546000268 D-loop; other site 167546000269 H-loop/switch region; other site 167546000270 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 167546000271 putative ABC transporter; Region: ycf24; CHL00085 167546000272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167546000273 phosphoglucomutase; Region: PLN02307 167546000274 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167546000275 active site 167546000276 substrate binding site [chemical binding]; other site 167546000277 metal binding site [ion binding]; metal-binding site 167546000278 recombination factor protein RarA; Reviewed; Region: PRK13342 167546000279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546000280 Walker A motif; other site 167546000281 ATP binding site [chemical binding]; other site 167546000282 Walker B motif; other site 167546000283 arginine finger; other site 167546000284 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167546000285 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167546000286 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167546000287 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 167546000288 catalytic triad [active] 167546000289 Type III pantothenate kinase; Region: Pan_kinase; cl17198 167546000290 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 167546000291 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167546000292 Active Sites [active] 167546000293 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167546000294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167546000295 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167546000296 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167546000297 transmembrane helices; other site 167546000298 TrkA-C domain; Region: TrkA_C; pfam02080 167546000299 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167546000300 TrkA-C domain; Region: TrkA_C; pfam02080 167546000301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167546000302 Cation transport protein; Region: TrkH; cl17365 167546000303 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167546000304 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 167546000305 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167546000306 TrkA-N domain; Region: TrkA_N; pfam02254 167546000307 TrkA-C domain; Region: TrkA_C; pfam02080 167546000308 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167546000309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167546000310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546000311 Walker A/P-loop; other site 167546000312 ATP binding site [chemical binding]; other site 167546000313 Q-loop/lid; other site 167546000314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167546000315 ABC transporter signature motif; other site 167546000316 Walker B; other site 167546000317 D-loop; other site 167546000318 H-loop/switch region; other site 167546000319 ABC transporter; Region: ABC_tran_2; pfam12848 167546000320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167546000321 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167546000322 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167546000323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167546000324 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167546000325 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 167546000326 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 167546000327 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167546000328 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167546000329 active site 167546000330 Outer membrane efflux protein; Region: OEP; pfam02321 167546000331 Outer membrane efflux protein; Region: OEP; pfam02321 167546000332 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167546000333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 167546000334 FeS/SAM binding site; other site 167546000335 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167546000336 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167546000337 L-aspartate oxidase; Provisional; Region: PRK06175 167546000338 L-aspartate oxidase; Provisional; Region: PRK07395 167546000339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167546000340 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 167546000341 substrate binding site [chemical binding]; other site 167546000342 putative active site [active] 167546000343 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167546000344 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 167546000345 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167546000346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546000347 FeS/SAM binding site; other site 167546000348 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 167546000349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 167546000350 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167546000351 RibD C-terminal domain; Region: RibD_C; cl17279 167546000352 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167546000353 active site 167546000354 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167546000355 active site 167546000356 shikimate kinase; Reviewed; Region: aroK; PRK00131 167546000357 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167546000358 ADP binding site [chemical binding]; other site 167546000359 magnesium binding site [ion binding]; other site 167546000360 putative shikimate binding site; other site 167546000361 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167546000362 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167546000363 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167546000364 C-terminal domain interface [polypeptide binding]; other site 167546000365 GSH binding site (G-site) [chemical binding]; other site 167546000366 dimer interface [polypeptide binding]; other site 167546000367 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167546000368 N-terminal domain interface [polypeptide binding]; other site 167546000369 dimer interface [polypeptide binding]; other site 167546000370 substrate binding pocket (H-site) [chemical binding]; other site 167546000371 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167546000372 Ribosome-binding factor A; Region: RBFA; pfam02033 167546000373 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 167546000374 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167546000375 active site 167546000376 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167546000377 putative hydrophobic ligand binding site [chemical binding]; other site 167546000378 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 167546000379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167546000380 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 167546000381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000382 TPR motif; other site 167546000383 binding surface 167546000384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167546000385 conserved hypothetical protein; Region: TIGR03492 167546000386 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167546000387 TIGR01777 family protein; Region: yfcH 167546000388 putative NAD(P) binding site [chemical binding]; other site 167546000389 putative active site [active] 167546000390 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167546000391 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167546000392 HSP70 interaction site [polypeptide binding]; other site 167546000393 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167546000394 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167546000395 dimer interface [polypeptide binding]; other site 167546000396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000397 catalytic residue [active] 167546000398 hypothetical protein; Provisional; Region: PRK13683 167546000399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167546000400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167546000401 Walker A/P-loop; other site 167546000402 ATP binding site [chemical binding]; other site 167546000403 Q-loop/lid; other site 167546000404 ABC transporter signature motif; other site 167546000405 Walker B; other site 167546000406 D-loop; other site 167546000407 H-loop/switch region; other site 167546000408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167546000409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546000410 active site 167546000411 phosphorylation site [posttranslational modification] 167546000412 intermolecular recognition site; other site 167546000413 dimerization interface [polypeptide binding]; other site 167546000414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167546000415 DNA binding site [nucleotide binding] 167546000416 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167546000417 DNA polymerase III subunit delta'; Validated; Region: PRK08485 167546000418 thymidylate kinase; Validated; Region: tmk; PRK00698 167546000419 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167546000420 TMP-binding site; other site 167546000421 ATP-binding site [chemical binding]; other site 167546000422 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167546000423 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167546000424 metal-binding site [ion binding] 167546000425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167546000426 Soluble P-type ATPase [General function prediction only]; Region: COG4087 167546000427 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167546000428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546000429 binding surface 167546000430 TPR motif; other site 167546000431 DNA repair protein RadA; Provisional; Region: PRK11823 167546000432 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167546000433 Walker A motif; other site 167546000434 ATP binding site [chemical binding]; other site 167546000435 Walker B motif; other site 167546000436 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 167546000437 Ycf27; Reviewed; Region: orf27; CHL00148 167546000438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546000439 active site 167546000440 phosphorylation site [posttranslational modification] 167546000441 intermolecular recognition site; other site 167546000442 dimerization interface [polypeptide binding]; other site 167546000443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167546000444 DNA binding site [nucleotide binding] 167546000445 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 167546000446 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 167546000447 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167546000448 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167546000449 dimer interface [polypeptide binding]; other site 167546000450 active site 167546000451 CoA binding pocket [chemical binding]; other site 167546000452 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 167546000453 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 167546000454 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167546000455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167546000456 putative acyl-acceptor binding pocket; other site 167546000457 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167546000458 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167546000459 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167546000460 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167546000461 active site 167546000462 NTP binding site [chemical binding]; other site 167546000463 metal binding triad [ion binding]; metal-binding site 167546000464 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167546000465 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167546000466 active site lid residues [active] 167546000467 substrate binding pocket [chemical binding]; other site 167546000468 catalytic residues [active] 167546000469 substrate-Mg2+ binding site; other site 167546000470 aspartate-rich region 1; other site 167546000471 aspartate-rich region 2; other site 167546000472 phytoene desaturase; Region: phytoene_desat; TIGR02731 167546000473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167546000474 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167546000475 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167546000476 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167546000477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 167546000478 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167546000479 putative dimerization interface [polypeptide binding]; other site 167546000480 Predicted membrane protein [Function unknown]; Region: COG4094 167546000481 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167546000482 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167546000483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167546000484 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167546000485 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167546000486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167546000487 ScpA/B protein; Region: ScpA_ScpB; cl00598 167546000488 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167546000489 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167546000490 active site 167546000491 Substrate binding site; other site 167546000492 Mg++ binding site; other site 167546000493 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167546000494 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167546000495 FAD binding site [chemical binding]; other site 167546000496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167546000497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167546000498 DNA binding residues [nucleotide binding] 167546000499 dimerization interface [polypeptide binding]; other site 167546000500 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167546000501 putative active site [active] 167546000502 putative metal binding residues [ion binding]; other site 167546000503 signature motif; other site 167546000504 putative dimer interface [polypeptide binding]; other site 167546000505 putative phosphate binding site [ion binding]; other site 167546000506 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 167546000507 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167546000508 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 167546000509 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 167546000510 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 167546000511 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 167546000512 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167546000513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167546000514 NADH dehydrogenase; Region: NADHdh; cl00469 167546000515 citrate synthase; Provisional; Region: PRK14036 167546000516 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 167546000517 oxalacetate binding site [chemical binding]; other site 167546000518 citrylCoA binding site [chemical binding]; other site 167546000519 coenzyme A binding site [chemical binding]; other site 167546000520 catalytic triad [active] 167546000521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 167546000522 active site residue [active] 167546000523 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 167546000524 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167546000525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000526 catalytic residue [active] 167546000527 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 167546000528 putative rRNA binding site [nucleotide binding]; other site 167546000529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546000530 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 167546000531 Walker A/P-loop; other site 167546000532 ligand-binding site [chemical binding]; other site 167546000533 ATP binding site [chemical binding]; other site 167546000534 AIR carboxylase; Region: AIRC; pfam00731 167546000535 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 167546000536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546000537 S-adenosylmethionine binding site [chemical binding]; other site 167546000538 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 167546000539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167546000540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546000541 active site 167546000542 phosphorylation site [posttranslational modification] 167546000543 intermolecular recognition site; other site 167546000544 dimerization interface [polypeptide binding]; other site 167546000545 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167546000546 DNA binding residues [nucleotide binding] 167546000547 dimerization interface [polypeptide binding]; other site 167546000548 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167546000549 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 167546000550 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546000551 catalytic residue [active] 167546000552 MraW methylase family; Region: Methyltransf_5; cl17771 167546000553 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 167546000554 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 167546000555 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 167546000556 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167546000557 active site 167546000558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 167546000559 acyl-activating enzyme (AAE) consensus motif; other site 167546000560 active site 167546000561 AMP binding site [chemical binding]; other site 167546000562 CoA binding site [chemical binding]; other site 167546000563 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167546000564 active site 167546000565 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 167546000566 UbiA prenyltransferase family; Region: UbiA; pfam01040 167546000567 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 167546000568 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167546000569 glutathione synthetase; Provisional; Region: PRK05246 167546000570 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167546000571 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 167546000572 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167546000573 GSH binding site [chemical binding]; other site 167546000574 catalytic residues [active] 167546000575 peptide chain release factor 2; Validated; Region: prfB; PRK00578 167546000576 PCRF domain; Region: PCRF; pfam03462 167546000577 RF-1 domain; Region: RF-1; pfam00472 167546000578 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167546000579 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 167546000580 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 167546000581 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167546000582 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167546000583 glutamine binding [chemical binding]; other site 167546000584 catalytic triad [active] 167546000585 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 167546000586 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167546000587 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167546000588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167546000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000590 homodimer interface [polypeptide binding]; other site 167546000591 catalytic residue [active] 167546000592 arginine-tRNA ligase; Region: PLN02286 167546000593 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 167546000594 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167546000595 active site 167546000596 HIGH motif; other site 167546000597 KMSK motif region; other site 167546000598 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 167546000599 tRNA binding surface [nucleotide binding]; other site 167546000600 anticodon binding site; other site 167546000601 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167546000602 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167546000603 dimerization interface [polypeptide binding]; other site 167546000604 active site 167546000605 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167546000606 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167546000607 trmE is a tRNA modification GTPase; Region: trmE; cd04164 167546000608 G1 box; other site 167546000609 GTP/Mg2+ binding site [chemical binding]; other site 167546000610 Switch I region; other site 167546000611 G2 box; other site 167546000612 Switch II region; other site 167546000613 G3 box; other site 167546000614 G4 box; other site 167546000615 G5 box; other site 167546000616 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167546000617 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 167546000618 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167546000619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167546000620 Zn2+ binding site [ion binding]; other site 167546000621 Mg2+ binding site [ion binding]; other site 167546000622 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167546000623 synthetase active site [active] 167546000624 NTP binding site [chemical binding]; other site 167546000625 metal binding site [ion binding]; metal-binding site 167546000626 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167546000627 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167546000628 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167546000629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167546000630 Walker A/P-loop; other site 167546000631 ATP binding site [chemical binding]; other site 167546000632 Q-loop/lid; other site 167546000633 ABC transporter signature motif; other site 167546000634 Walker B; other site 167546000635 D-loop; other site 167546000636 H-loop/switch region; other site 167546000637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167546000638 Walker A/P-loop; other site 167546000639 ATP binding site [chemical binding]; other site 167546000640 Q-loop/lid; other site 167546000641 ABC transporter signature motif; other site 167546000642 Walker B; other site 167546000643 D-loop; other site 167546000644 H-loop/switch region; other site 167546000645 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 167546000646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546000647 RNA binding surface [nucleotide binding]; other site 167546000648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 167546000649 active site 167546000650 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167546000651 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 167546000652 GTP/Mg2+ binding site [chemical binding]; other site 167546000653 G4 box; other site 167546000654 G5 box; other site 167546000655 G1 box; other site 167546000656 Switch I region; other site 167546000657 G2 box; other site 167546000658 G3 box; other site 167546000659 Switch II region; other site 167546000660 Phosphoglycerate kinase; Region: PGK; pfam00162 167546000661 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167546000662 substrate binding site [chemical binding]; other site 167546000663 hinge regions; other site 167546000664 ADP binding site [chemical binding]; other site 167546000665 catalytic site [active] 167546000666 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167546000667 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 167546000668 active site 167546000669 homodimer interface [polypeptide binding]; other site 167546000670 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167546000671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167546000672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000673 homodimer interface [polypeptide binding]; other site 167546000674 catalytic residue [active] 167546000675 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 167546000676 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167546000677 active site 167546000678 catalytic residues [active] 167546000679 FMN binding site [chemical binding]; other site 167546000680 quinone interaction residues [chemical binding]; other site 167546000681 substrate binding site [chemical binding]; other site 167546000682 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167546000683 RNA/DNA hybrid binding site [nucleotide binding]; other site 167546000684 active site 167546000685 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167546000686 L11 interface [polypeptide binding]; other site 167546000687 putative EF-Tu interaction site [polypeptide binding]; other site 167546000688 putative EF-G interaction site [polypeptide binding]; other site 167546000689 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167546000690 23S rRNA interface [nucleotide binding]; other site 167546000691 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167546000692 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167546000693 mRNA/rRNA interface [nucleotide binding]; other site 167546000694 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167546000695 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167546000696 23S rRNA interface [nucleotide binding]; other site 167546000697 L7/L12 interface [polypeptide binding]; other site 167546000698 putative thiostrepton binding site; other site 167546000699 L25 interface [polypeptide binding]; other site 167546000700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167546000701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167546000702 putative homodimer interface [polypeptide binding]; other site 167546000703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 167546000704 heterodimer interface [polypeptide binding]; other site 167546000705 homodimer interface [polypeptide binding]; other site 167546000706 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 167546000707 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167546000708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546000709 Walker A motif; other site 167546000710 ATP binding site [chemical binding]; other site 167546000711 Walker B motif; other site 167546000712 arginine finger; other site 167546000713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546000714 Walker A motif; other site 167546000715 ATP binding site [chemical binding]; other site 167546000716 Walker B motif; other site 167546000717 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167546000718 enolase; Provisional; Region: eno; PRK00077 167546000719 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167546000720 dimer interface [polypeptide binding]; other site 167546000721 metal binding site [ion binding]; metal-binding site 167546000722 substrate binding pocket [chemical binding]; other site 167546000723 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167546000724 ABC1 family; Region: ABC1; cl17513 167546000725 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167546000726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167546000727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167546000728 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167546000729 Domain of unknown function (DUF897); Region: DUF897; pfam05982 167546000730 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167546000731 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167546000732 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167546000733 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167546000734 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167546000735 dimer interface [polypeptide binding]; other site 167546000736 allosteric magnesium binding site [ion binding]; other site 167546000737 active site 167546000738 aspartate-rich active site metal binding site; other site 167546000739 Schiff base residues; other site 167546000740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167546000741 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167546000742 active site 167546000743 metal binding site [ion binding]; metal-binding site 167546000744 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167546000745 MutS domain III; Region: MutS_III; pfam05192 167546000746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546000747 Walker A/P-loop; other site 167546000748 ATP binding site [chemical binding]; other site 167546000749 Q-loop/lid; other site 167546000750 ABC transporter signature motif; other site 167546000751 Walker B; other site 167546000752 D-loop; other site 167546000753 H-loop/switch region; other site 167546000754 Smr domain; Region: Smr; pfam01713 167546000755 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 167546000756 GTP1/OBG; Region: GTP1_OBG; pfam01018 167546000757 Obg GTPase; Region: Obg; cd01898 167546000758 G1 box; other site 167546000759 GTP/Mg2+ binding site [chemical binding]; other site 167546000760 Switch I region; other site 167546000761 G2 box; other site 167546000762 G3 box; other site 167546000763 Switch II region; other site 167546000764 G4 box; other site 167546000765 CP12 domain; Region: CP12; pfam02672 167546000766 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167546000767 putative dimer interface [polypeptide binding]; other site 167546000768 N-terminal domain interface [polypeptide binding]; other site 167546000769 putative substrate binding pocket (H-site) [chemical binding]; other site 167546000770 aspartoacylase; Provisional; Region: PRK02259 167546000771 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167546000772 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167546000773 protein I interface; other site 167546000774 D2 interface; other site 167546000775 protein T interface; other site 167546000776 chlorophyll binding site; other site 167546000777 beta carotene binding site; other site 167546000778 pheophytin binding site; other site 167546000779 manganese-stabilizing polypeptide interface; other site 167546000780 CP43 interface; other site 167546000781 protein L interface; other site 167546000782 oxygen evolving complex binding site; other site 167546000783 bromide binding site; other site 167546000784 quinone binding site; other site 167546000785 Fe binding site [ion binding]; other site 167546000786 core light harvesting interface; other site 167546000787 cytochrome b559 alpha subunit interface; other site 167546000788 cytochrome c-550 interface; other site 167546000789 protein J interface; other site 167546000790 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 167546000791 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167546000792 Tetramer interface [polypeptide binding]; other site 167546000793 active site 167546000794 FMN-binding site [chemical binding]; other site 167546000795 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167546000796 active site 167546000797 intersubunit interface [polypeptide binding]; other site 167546000798 catalytic residue [active] 167546000799 FtsH Extracellular; Region: FtsH_ext; pfam06480 167546000800 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167546000801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546000802 Walker A motif; other site 167546000803 ATP binding site [chemical binding]; other site 167546000804 Walker B motif; other site 167546000805 arginine finger; other site 167546000806 Peptidase family M41; Region: Peptidase_M41; pfam01434 167546000807 ATP sulphurylase; Region: sopT; TIGR00339 167546000808 ATP-sulfurylase; Region: ATPS; cd00517 167546000809 active site 167546000810 HXXH motif; other site 167546000811 flexible loop; other site 167546000812 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 167546000813 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167546000814 Flavoprotein; Region: Flavoprotein; pfam02441 167546000815 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 167546000816 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 167546000817 Protein of unknown function (DUF565); Region: DUF565; pfam04483 167546000818 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167546000819 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167546000820 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167546000821 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 167546000822 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 167546000823 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167546000824 putative di-iron ligands [ion binding]; other site 167546000825 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167546000826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167546000827 active site 167546000828 HIGH motif; other site 167546000829 nucleotide binding site [chemical binding]; other site 167546000830 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167546000831 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167546000832 active site 167546000833 KMSKS motif; other site 167546000834 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167546000835 tRNA binding surface [nucleotide binding]; other site 167546000836 anticodon binding site; other site 167546000837 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167546000838 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167546000839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546000840 S-adenosylmethionine binding site [chemical binding]; other site 167546000841 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 167546000842 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 167546000843 active site 167546000844 substrate binding site [chemical binding]; other site 167546000845 metal binding site [ion binding]; metal-binding site 167546000846 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167546000847 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 167546000848 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 167546000849 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167546000850 trimer interface [polypeptide binding]; other site 167546000851 active site 167546000852 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 167546000853 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167546000854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167546000855 ligand binding site [chemical binding]; other site 167546000856 flexible hinge region; other site 167546000857 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167546000858 putative switch regulator; other site 167546000859 non-specific DNA interactions [nucleotide binding]; other site 167546000860 DNA binding site [nucleotide binding] 167546000861 sequence specific DNA binding site [nucleotide binding]; other site 167546000862 putative cAMP binding site [chemical binding]; other site 167546000863 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167546000864 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 167546000865 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167546000866 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167546000867 putative active site [active] 167546000868 catalytic residue [active] 167546000869 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 167546000870 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 167546000871 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 167546000872 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 167546000873 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167546000874 hypothetical protein; Provisional; Region: PRK14812 167546000875 substrate binding site [chemical binding]; other site 167546000876 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167546000877 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 167546000878 substrate binding site [chemical binding]; other site 167546000879 ligand binding site [chemical binding]; other site 167546000880 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167546000881 competence damage-inducible protein A; Provisional; Region: PRK00549 167546000882 putative MPT binding site; other site 167546000883 Competence-damaged protein; Region: CinA; pfam02464 167546000884 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 167546000885 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167546000886 dimer interface [polypeptide binding]; other site 167546000887 active site 167546000888 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167546000889 folate binding site [chemical binding]; other site 167546000890 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167546000891 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 167546000892 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 167546000893 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 167546000894 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 167546000895 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 167546000896 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 167546000897 DoxX; Region: DoxX; pfam07681 167546000898 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167546000899 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167546000900 purine monophosphate binding site [chemical binding]; other site 167546000901 dimer interface [polypeptide binding]; other site 167546000902 putative catalytic residues [active] 167546000903 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 167546000904 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167546000905 Predicted esterase [General function prediction only]; Region: COG0400 167546000906 putative hydrolase; Provisional; Region: PRK11460 167546000907 Serine hydrolase (FSH1); Region: FSH1; pfam03959 167546000908 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167546000909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167546000910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167546000911 dimer interface [polypeptide binding]; other site 167546000912 phosphorylation site [posttranslational modification] 167546000913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546000914 ATP binding site [chemical binding]; other site 167546000915 Mg2+ binding site [ion binding]; other site 167546000916 G-X-G motif; other site 167546000917 cobalamin synthase; Reviewed; Region: cobS; PRK00235 167546000918 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 167546000919 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 167546000920 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 167546000921 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167546000922 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167546000923 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167546000924 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167546000925 Domain of unknown function DUF21; Region: DUF21; pfam01595 167546000926 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167546000927 Transporter associated domain; Region: CorC_HlyC; smart01091 167546000928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546000929 active site 167546000930 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 167546000931 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167546000932 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167546000933 RNase_H superfamily; Region: RNase_H_2; pfam13482 167546000934 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167546000935 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167546000936 active site 167546000937 substrate binding site [chemical binding]; other site 167546000938 metal binding site [ion binding]; metal-binding site 167546000939 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167546000940 active site 167546000941 dimerization interface [polypeptide binding]; other site 167546000942 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 167546000943 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 167546000944 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 167546000945 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167546000946 putative active site pocket [active] 167546000947 4-fold oligomerization interface [polypeptide binding]; other site 167546000948 metal binding residues [ion binding]; metal-binding site 167546000949 3-fold/trimer interface [polypeptide binding]; other site 167546000950 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 167546000951 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167546000952 NAD binding site [chemical binding]; other site 167546000953 homotetramer interface [polypeptide binding]; other site 167546000954 homodimer interface [polypeptide binding]; other site 167546000955 substrate binding site [chemical binding]; other site 167546000956 active site 167546000957 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167546000958 putative catalytic residue [active] 167546000959 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167546000960 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167546000961 inhibitor-cofactor binding pocket; inhibition site 167546000962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546000963 catalytic residue [active] 167546000964 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 167546000965 DNA photolyase; Region: DNA_photolyase; pfam00875 167546000966 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167546000967 dimer interface [polypeptide binding]; other site 167546000968 ADP-ribose binding site [chemical binding]; other site 167546000969 active site 167546000970 nudix motif; other site 167546000971 metal binding site [ion binding]; metal-binding site 167546000972 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167546000973 catalytic center binding site [active] 167546000974 ATP binding site [chemical binding]; other site 167546000975 Protein of unknown function (DUF444); Region: DUF444; cl17371 167546000976 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167546000977 metal ion-dependent adhesion site (MIDAS); other site 167546000978 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 167546000979 mce related protein; Region: MCE; pfam02470 167546000980 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167546000981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546000982 Walker A/P-loop; other site 167546000983 ATP binding site [chemical binding]; other site 167546000984 Q-loop/lid; other site 167546000985 ABC transporter signature motif; other site 167546000986 Walker B; other site 167546000987 D-loop; other site 167546000988 H-loop/switch region; other site 167546000989 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 167546000990 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167546000991 phosphate binding site [ion binding]; other site 167546000992 putative substrate binding pocket [chemical binding]; other site 167546000993 dimer interface [polypeptide binding]; other site 167546000994 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 167546000995 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 167546000996 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 167546000997 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 167546000998 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167546000999 Rubredoxin; Region: Rubredoxin; pfam00301 167546001000 iron binding site [ion binding]; other site 167546001001 Ycf48-like protein; Provisional; Region: PRK13684 167546001002 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167546001003 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 167546001004 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167546001005 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167546001006 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 167546001007 photosystem II reaction center protein J; Provisional; Region: PRK02565 167546001008 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167546001009 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167546001010 selenium donor protein; Region: selD; TIGR00476 167546001011 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 167546001012 dimerization interface [polypeptide binding]; other site 167546001013 ATP binding site [chemical binding]; other site 167546001014 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167546001015 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167546001016 active site 167546001017 NTP binding site [chemical binding]; other site 167546001018 metal binding triad [ion binding]; metal-binding site 167546001019 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167546001020 Part of AAA domain; Region: AAA_19; pfam13245 167546001021 Family description; Region: UvrD_C_2; pfam13538 167546001022 Phycobilisome protein; Region: Phycobilisome; cl08227 167546001023 CpeS-like protein; Region: CpeS; pfam09367 167546001024 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167546001025 D-xylulose kinase; Region: XylB; TIGR01312 167546001026 nucleotide binding site [chemical binding]; other site 167546001027 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167546001028 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167546001029 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167546001030 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167546001031 30S ribosomal protein S1; Reviewed; Region: PRK07400 167546001032 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167546001033 RNA binding site [nucleotide binding]; other site 167546001034 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167546001035 RNA binding site [nucleotide binding]; other site 167546001036 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 167546001037 RNA binding site [nucleotide binding]; other site 167546001038 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167546001039 ATP cone domain; Region: ATP-cone; pfam03477 167546001040 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 167546001041 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 167546001042 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167546001043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167546001044 catalytic loop [active] 167546001045 iron binding site [ion binding]; other site 167546001046 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 167546001047 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 167546001048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001049 S-adenosylmethionine binding site [chemical binding]; other site 167546001050 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 167546001051 cell division topological specificity factor MinE; Provisional; Region: PRK13988 167546001052 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167546001053 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167546001054 P-loop; other site 167546001055 ADP binding residues [chemical binding]; other site 167546001056 Switch I; other site 167546001057 Switch II; other site 167546001058 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167546001059 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167546001060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167546001061 Zn2+ binding site [ion binding]; other site 167546001062 Mg2+ binding site [ion binding]; other site 167546001063 carboxyl-terminal processing protease; Provisional; Region: PLN00049 167546001064 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167546001065 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167546001066 protein binding site [polypeptide binding]; other site 167546001067 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167546001068 Catalytic dyad [active] 167546001069 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167546001070 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167546001071 Qi binding site; other site 167546001072 intrachain domain interface; other site 167546001073 interchain domain interface [polypeptide binding]; other site 167546001074 heme bH binding site [chemical binding]; other site 167546001075 heme bL binding site [chemical binding]; other site 167546001076 Qo binding site; other site 167546001077 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167546001078 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167546001079 interchain domain interface [polypeptide binding]; other site 167546001080 intrachain domain interface; other site 167546001081 Qi binding site; other site 167546001082 Qo binding site; other site 167546001083 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 167546001084 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167546001085 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167546001086 DNA binding site [nucleotide binding] 167546001087 catalytic residue [active] 167546001088 H2TH interface [polypeptide binding]; other site 167546001089 putative catalytic residues [active] 167546001090 turnover-facilitating residue; other site 167546001091 intercalation triad [nucleotide binding]; other site 167546001092 8OG recognition residue [nucleotide binding]; other site 167546001093 putative reading head residues; other site 167546001094 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167546001095 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167546001096 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 167546001097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167546001098 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 167546001099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167546001100 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167546001101 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 167546001102 NAD(P) binding site [chemical binding]; other site 167546001103 catalytic residues [active] 167546001104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167546001105 Coenzyme A binding pocket [chemical binding]; other site 167546001106 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167546001107 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167546001108 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 167546001109 dinuclear metal binding motif [ion binding]; other site 167546001110 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 167546001111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167546001112 carotene isomerase; Region: carot_isom; TIGR02730 167546001113 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167546001114 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 167546001115 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 167546001116 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167546001117 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167546001118 catalytic triad [active] 167546001119 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167546001120 hypothetical protein; Provisional; Region: PRK09256 167546001121 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546001122 CAAX protease self-immunity; Region: Abi; pfam02517 167546001123 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167546001124 TAP-like protein; Region: Abhydrolase_4; pfam08386 167546001125 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 167546001126 DNA photolyase; Region: DNA_photolyase; pfam00875 167546001127 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 167546001128 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 167546001129 substrate binding site [chemical binding]; other site 167546001130 dimer interface [polypeptide binding]; other site 167546001131 ATP binding site [chemical binding]; other site 167546001132 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 167546001133 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 167546001134 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167546001135 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167546001136 Dehydroquinase class II; Region: DHquinase_II; pfam01220 167546001137 active site 167546001138 trimer interface [polypeptide binding]; other site 167546001139 dimer interface [polypeptide binding]; other site 167546001140 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167546001141 active site 167546001142 dinuclear metal binding site [ion binding]; other site 167546001143 dimerization interface [polypeptide binding]; other site 167546001144 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 167546001145 active site 167546001146 SAM binding site [chemical binding]; other site 167546001147 homodimer interface [polypeptide binding]; other site 167546001148 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 167546001149 GTP-binding protein Der; Reviewed; Region: PRK00093 167546001150 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 167546001151 G1 box; other site 167546001152 GTP/Mg2+ binding site [chemical binding]; other site 167546001153 Switch I region; other site 167546001154 G2 box; other site 167546001155 Switch II region; other site 167546001156 G3 box; other site 167546001157 G4 box; other site 167546001158 G5 box; other site 167546001159 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 167546001160 G1 box; other site 167546001161 GTP/Mg2+ binding site [chemical binding]; other site 167546001162 Switch I region; other site 167546001163 G2 box; other site 167546001164 G3 box; other site 167546001165 Switch II region; other site 167546001166 G4 box; other site 167546001167 G5 box; other site 167546001168 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 167546001169 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167546001170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 167546001171 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167546001172 catalytic residue [active] 167546001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 167546001174 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 167546001175 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 167546001176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167546001177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167546001178 Recombination protein O N terminal; Region: RecO_N; pfam11967 167546001179 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 167546001180 Recombination protein O C terminal; Region: RecO_C; pfam02565 167546001181 Class I aldolases; Region: Aldolase_Class_I; cl17187 167546001182 catalytic residue [active] 167546001183 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 167546001184 30S subunit binding site; other site 167546001185 lipoate-protein ligase B; Provisional; Region: PRK14344 167546001186 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167546001187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 167546001188 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 167546001189 acyl-activating enzyme (AAE) consensus motif; other site 167546001190 acyl-activating enzyme (AAE) consensus motif; other site 167546001191 putative AMP binding site [chemical binding]; other site 167546001192 putative active site [active] 167546001193 putative CoA binding site [chemical binding]; other site 167546001194 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 167546001195 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167546001196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167546001197 E3 interaction surface; other site 167546001198 lipoyl attachment site [posttranslational modification]; other site 167546001199 e3 binding domain; Region: E3_binding; pfam02817 167546001200 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 167546001201 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 167546001202 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 167546001203 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167546001204 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167546001205 dimer interface [polypeptide binding]; other site 167546001206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546001207 catalytic residue [active] 167546001208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546001209 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 167546001210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546001211 catalytic residue [active] 167546001212 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 167546001213 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167546001214 homodimer interface [polypeptide binding]; other site 167546001215 substrate-cofactor binding pocket; other site 167546001216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546001217 catalytic residue [active] 167546001218 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167546001219 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167546001220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546001221 RNA binding surface [nucleotide binding]; other site 167546001222 Haemolytic domain; Region: Haemolytic; cl00506 167546001223 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 167546001224 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167546001225 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167546001226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167546001227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167546001228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546001229 NAD(P) binding site [chemical binding]; other site 167546001230 active site 167546001231 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167546001232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546001233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546001234 catalytic residue [active] 167546001235 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167546001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001237 S-adenosylmethionine binding site [chemical binding]; other site 167546001238 NifU-like domain; Region: NifU; pfam01106 167546001239 malate:quinone oxidoreductase; Validated; Region: PRK05257 167546001240 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 167546001241 GTP-binding protein LepA; Provisional; Region: PRK05433 167546001242 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 167546001243 G1 box; other site 167546001244 putative GEF interaction site [polypeptide binding]; other site 167546001245 GTP/Mg2+ binding site [chemical binding]; other site 167546001246 Switch I region; other site 167546001247 G2 box; other site 167546001248 G3 box; other site 167546001249 Switch II region; other site 167546001250 G4 box; other site 167546001251 G5 box; other site 167546001252 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167546001253 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167546001254 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167546001255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 167546001256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546001257 dimer interface [polypeptide binding]; other site 167546001258 conserved gate region; other site 167546001259 ABC-ATPase subunit interface; other site 167546001260 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167546001261 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167546001262 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167546001263 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167546001264 TIGR03643 family protein; Region: TIGR03643 167546001265 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 167546001266 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 167546001267 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167546001268 NusB family; Region: NusB; pfam01029 167546001269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001270 S-adenosylmethionine binding site [chemical binding]; other site 167546001271 Transglycosylase; Region: Transgly; pfam00912 167546001272 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 167546001273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 167546001274 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 167546001275 UbiA prenyltransferase family; Region: UbiA; pfam01040 167546001276 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167546001277 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167546001278 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167546001279 substrate binding site [chemical binding]; other site 167546001280 glutamase interaction surface [polypeptide binding]; other site 167546001281 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167546001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001283 S-adenosylmethionine binding site [chemical binding]; other site 167546001284 Protein of unknown function (DUF721); Region: DUF721; pfam05258 167546001285 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 167546001286 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 167546001287 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167546001288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167546001289 Walker A/P-loop; other site 167546001290 ATP binding site [chemical binding]; other site 167546001291 Q-loop/lid; other site 167546001292 ABC transporter signature motif; other site 167546001293 Walker B; other site 167546001294 D-loop; other site 167546001295 H-loop/switch region; other site 167546001296 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 167546001297 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167546001298 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167546001299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 167546001300 active site 167546001301 interdomain interaction site; other site 167546001302 putative metal-binding site [ion binding]; other site 167546001303 nucleotide binding site [chemical binding]; other site 167546001304 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 167546001305 domain I; other site 167546001306 phosphate binding site [ion binding]; other site 167546001307 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167546001308 domain II; other site 167546001309 domain III; other site 167546001310 nucleotide binding site [chemical binding]; other site 167546001311 DNA binding groove [nucleotide binding] 167546001312 catalytic site [active] 167546001313 domain IV; other site 167546001314 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167546001315 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167546001316 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 167546001317 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167546001318 active site pocket [active] 167546001319 putative dimer interface [polypeptide binding]; other site 167546001320 putative cataytic base [active] 167546001321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167546001322 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167546001323 active site 167546001324 catalytic tetrad [active] 167546001325 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167546001326 Lumazine binding domain; Region: Lum_binding; pfam00677 167546001327 Lumazine binding domain; Region: Lum_binding; pfam00677 167546001328 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167546001329 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167546001330 Subunit I/III interface [polypeptide binding]; other site 167546001331 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 167546001332 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 167546001333 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 167546001334 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 167546001335 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 167546001336 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 167546001337 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 167546001338 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 167546001339 UbiA prenyltransferase family; Region: UbiA; pfam01040 167546001340 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 167546001341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546001342 Walker A/P-loop; other site 167546001343 ATP binding site [chemical binding]; other site 167546001344 Q-loop/lid; other site 167546001345 ABC transporter signature motif; other site 167546001346 Walker B; other site 167546001347 D-loop; other site 167546001348 H-loop/switch region; other site 167546001349 ABC-2 type transporter; Region: ABC2_membrane; cl17235 167546001350 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 167546001351 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167546001352 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167546001353 ring oligomerisation interface [polypeptide binding]; other site 167546001354 ATP/Mg binding site [chemical binding]; other site 167546001355 stacking interactions; other site 167546001356 hinge regions; other site 167546001357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167546001358 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167546001359 NAD(P) binding site [chemical binding]; other site 167546001360 homotetramer interface [polypeptide binding]; other site 167546001361 homodimer interface [polypeptide binding]; other site 167546001362 active site 167546001363 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167546001364 substrate binding site; other site 167546001365 dimer interface; other site 167546001366 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167546001367 dimer interface [polypeptide binding]; other site 167546001368 catalytic triad [active] 167546001369 prenyltransferase; Reviewed; Region: ubiA; PRK12873 167546001370 UbiA prenyltransferase family; Region: UbiA; pfam01040 167546001371 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 167546001372 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 167546001373 Helix-turn-helix domain; Region: HTH_25; pfam13413 167546001374 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 167546001375 active site 167546001376 SAM binding site [chemical binding]; other site 167546001377 homodimer interface [polypeptide binding]; other site 167546001378 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 167546001379 cytochrome f; Region: petA; CHL00037 167546001380 apocytochrome f; Reviewed; Region: PRK02693 167546001381 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167546001382 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167546001383 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 167546001384 cytochrome b subunit interaction site [polypeptide binding]; other site 167546001385 [2Fe-2S] cluster binding site [ion binding]; other site 167546001386 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 167546001387 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 167546001388 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 167546001389 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167546001390 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 167546001391 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167546001392 catalytic site [active] 167546001393 G-X2-G-X-G-K; other site 167546001394 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 167546001395 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167546001396 UGMP family protein; Validated; Region: PRK09604 167546001397 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167546001398 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 167546001399 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167546001400 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167546001401 active site 167546001402 HIGH motif; other site 167546001403 nucleotide binding site [chemical binding]; other site 167546001404 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167546001405 active site 167546001406 KMSKS motif; other site 167546001407 Src Homology 3 domain superfamily; Region: SH3; cl17036 167546001408 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 167546001409 methionine aminopeptidase; Provisional; Region: PRK08671 167546001410 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167546001411 active site 167546001412 short chain dehydrogenase; Provisional; Region: PRK12367 167546001413 NAD(P) binding site [chemical binding]; other site 167546001414 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167546001415 DRTGG domain; Region: DRTGG; pfam07085 167546001416 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 167546001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 167546001418 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 167546001419 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 167546001420 SPFH domain / Band 7 family; Region: Band_7; pfam01145 167546001421 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167546001422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167546001423 inhibitor-cofactor binding pocket; inhibition site 167546001424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546001425 catalytic residue [active] 167546001426 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167546001427 putative catalytic site [active] 167546001428 putative phosphate binding site [ion binding]; other site 167546001429 active site 167546001430 metal binding site A [ion binding]; metal-binding site 167546001431 DNA binding site [nucleotide binding] 167546001432 putative AP binding site [nucleotide binding]; other site 167546001433 putative metal binding site B [ion binding]; other site 167546001434 hypothetical protein; Provisional; Region: PRK04194 167546001435 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 167546001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546001437 dimer interface [polypeptide binding]; other site 167546001438 conserved gate region; other site 167546001439 putative PBP binding loops; other site 167546001440 ABC-ATPase subunit interface; other site 167546001441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546001442 dimer interface [polypeptide binding]; other site 167546001443 conserved gate region; other site 167546001444 putative PBP binding loops; other site 167546001445 ABC-ATPase subunit interface; other site 167546001446 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167546001447 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167546001448 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167546001449 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 167546001450 aromatic arch; other site 167546001451 DCoH dimer interaction site [polypeptide binding]; other site 167546001452 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167546001453 DCoH tetramer interaction site [polypeptide binding]; other site 167546001454 substrate binding site [chemical binding]; other site 167546001455 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 167546001456 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 167546001457 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167546001458 active site 167546001459 Zn binding site [ion binding]; other site 167546001460 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167546001461 dimer interface [polypeptide binding]; other site 167546001462 substrate binding site [chemical binding]; other site 167546001463 metal binding sites [ion binding]; metal-binding site 167546001464 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167546001465 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167546001466 domain interfaces; other site 167546001467 active site 167546001468 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167546001469 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167546001470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167546001471 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167546001472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167546001473 DNA binding residues [nucleotide binding] 167546001474 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 167546001475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546001476 ATP binding site [chemical binding]; other site 167546001477 putative Mg++ binding site [ion binding]; other site 167546001478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546001479 ATP-binding site [chemical binding]; other site 167546001480 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167546001481 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167546001482 feedback inhibition sensing region; other site 167546001483 homohexameric interface [polypeptide binding]; other site 167546001484 nucleotide binding site [chemical binding]; other site 167546001485 N-acetyl-L-glutamate binding site [chemical binding]; other site 167546001486 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167546001487 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167546001488 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167546001489 ssDNA binding site [nucleotide binding]; other site 167546001490 dimer interface [polypeptide binding]; other site 167546001491 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167546001492 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 167546001493 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 167546001494 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 167546001495 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167546001496 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 167546001497 substrate binding site [chemical binding]; other site 167546001498 ATP binding site [chemical binding]; other site 167546001499 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 167546001500 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167546001501 GDP-binding site [chemical binding]; other site 167546001502 ACT binding site; other site 167546001503 IMP binding site; other site 167546001504 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 167546001505 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167546001506 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 167546001507 dimer interface [polypeptide binding]; other site 167546001508 motif 1; other site 167546001509 active site 167546001510 motif 2; other site 167546001511 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167546001512 putative deacylase active site [active] 167546001513 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167546001514 motif 3; other site 167546001515 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167546001516 anticodon binding site; other site 167546001517 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167546001518 dimer interface [polypeptide binding]; other site 167546001519 substrate binding site [chemical binding]; other site 167546001520 metal binding sites [ion binding]; metal-binding site 167546001521 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167546001522 ArsC family; Region: ArsC; pfam03960 167546001523 putative ArsC-like catalytic residues; other site 167546001524 putative TRX-like catalytic residues [active] 167546001525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167546001526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167546001527 Catalytic site [active] 167546001528 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167546001529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167546001530 catalytic core [active] 167546001531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167546001532 catalytic core [active] 167546001533 CAAX protease self-immunity; Region: Abi; pfam02517 167546001534 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167546001535 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167546001536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167546001537 transaldolase-like protein; Provisional; Region: PTZ00411 167546001538 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167546001539 active site 167546001540 dimer interface [polypeptide binding]; other site 167546001541 catalytic residue [active] 167546001542 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 167546001543 ribosome recycling factor; Reviewed; Region: frr; PRK00083 167546001544 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 167546001545 hinge region; other site 167546001546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167546001547 putative nucleotide binding site [chemical binding]; other site 167546001548 uridine monophosphate binding site [chemical binding]; other site 167546001549 homohexameric interface [polypeptide binding]; other site 167546001550 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167546001551 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167546001552 homodimer interface [polypeptide binding]; other site 167546001553 Walker A motif; other site 167546001554 ATP binding site [chemical binding]; other site 167546001555 hydroxycobalamin binding site [chemical binding]; other site 167546001556 Walker B motif; other site 167546001557 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167546001558 active site 167546001559 catalytic residues [active] 167546001560 DNA binding site [nucleotide binding] 167546001561 Int/Topo IB signature motif; other site 167546001562 ferrochelatase; Reviewed; Region: hemH; PRK00035 167546001563 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167546001564 C-terminal domain interface [polypeptide binding]; other site 167546001565 active site 167546001566 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167546001567 active site 167546001568 N-terminal domain interface [polypeptide binding]; other site 167546001569 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167546001570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167546001571 PYR/PP interface [polypeptide binding]; other site 167546001572 dimer interface [polypeptide binding]; other site 167546001573 TPP binding site [chemical binding]; other site 167546001574 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 167546001575 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167546001576 TPP-binding site [chemical binding]; other site 167546001577 dimer interface [polypeptide binding]; other site 167546001578 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 167546001579 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167546001580 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167546001581 RNA binding site [nucleotide binding]; other site 167546001582 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167546001583 RNA binding site [nucleotide binding]; other site 167546001584 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167546001585 RNA binding site [nucleotide binding]; other site 167546001586 Creatinine amidohydrolase; Region: Creatininase; pfam02633 167546001587 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167546001588 dinuclear metal binding motif [ion binding]; other site 167546001589 acyl-ACP reductase; Provisional; Region: PRK14982 167546001590 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 167546001591 NAD(P) binding pocket [chemical binding]; other site 167546001592 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 167546001593 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 167546001594 short chain dehydrogenase; Provisional; Region: PRK07454 167546001595 classical (c) SDRs; Region: SDR_c; cd05233 167546001596 NAD(P) binding site [chemical binding]; other site 167546001597 active site 167546001598 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167546001599 GTP cyclohydrolase I; Provisional; Region: PLN03044 167546001600 active site 167546001601 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 167546001602 active site 167546001603 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167546001604 active site 167546001605 putative substrate binding region [chemical binding]; other site 167546001606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167546001607 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 167546001608 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 167546001609 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 167546001610 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 167546001611 NAD(P) binding site [chemical binding]; other site 167546001612 active site 167546001613 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167546001614 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167546001615 P-loop; other site 167546001616 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167546001617 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167546001618 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167546001619 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 167546001620 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 167546001621 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167546001622 putative hexamer interface [polypeptide binding]; other site 167546001623 putative hexagonal pore; other site 167546001624 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167546001625 putative hexamer interface [polypeptide binding]; other site 167546001626 putative hexagonal pore; other site 167546001627 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167546001628 active site 167546001629 dimerization interface [polypeptide binding]; other site 167546001630 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 167546001631 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167546001632 Hexamer interface [polypeptide binding]; other site 167546001633 Hexagonal pore residue; other site 167546001634 Hexagonal pore; other site 167546001635 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167546001636 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167546001637 dimer interface [polypeptide binding]; other site 167546001638 catalytic residue [active] 167546001639 metal binding site [ion binding]; metal-binding site 167546001640 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167546001641 multimerization interface [polypeptide binding]; other site 167546001642 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167546001643 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167546001644 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 167546001645 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167546001646 Hexamer/Pentamer interface [polypeptide binding]; other site 167546001647 central pore; other site 167546001648 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167546001649 Hexamer/Pentamer interface [polypeptide binding]; other site 167546001650 central pore; other site 167546001651 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167546001652 DCoH dimer interaction site [polypeptide binding]; other site 167546001653 aromatic arch; other site 167546001654 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167546001655 DCoH tetramer interaction site [polypeptide binding]; other site 167546001656 substrate binding site [chemical binding]; other site 167546001657 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167546001658 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167546001659 homotrimer interaction site [polypeptide binding]; other site 167546001660 putative active site [active] 167546001661 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 167546001662 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 167546001663 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 167546001664 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167546001665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167546001666 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 167546001667 Walker A/P-loop; other site 167546001668 ATP binding site [chemical binding]; other site 167546001669 Q-loop/lid; other site 167546001670 ABC transporter signature motif; other site 167546001671 Walker B; other site 167546001672 D-loop; other site 167546001673 H-loop/switch region; other site 167546001674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167546001675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167546001676 Coenzyme A binding pocket [chemical binding]; other site 167546001677 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167546001678 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 167546001679 Probable Catalytic site; other site 167546001680 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 167546001681 DnaA N-terminal domain; Region: DnaA_N; pfam11638 167546001682 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 167546001683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546001684 Walker A motif; other site 167546001685 ATP binding site [chemical binding]; other site 167546001686 Walker B motif; other site 167546001687 arginine finger; other site 167546001688 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167546001689 DnaA box-binding interface [nucleotide binding]; other site 167546001690 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167546001691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167546001692 C-terminal domain interface [polypeptide binding]; other site 167546001693 GSH binding site (G-site) [chemical binding]; other site 167546001694 dimer interface [polypeptide binding]; other site 167546001695 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 167546001696 glutathione reductase; Validated; Region: PRK06116 167546001697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167546001698 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167546001699 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 167546001700 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167546001701 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167546001702 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167546001703 active site 167546001704 substrate binding pocket [chemical binding]; other site 167546001705 dimer interface [polypeptide binding]; other site 167546001706 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167546001707 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167546001708 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 167546001709 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167546001710 substrate binding site [chemical binding]; other site 167546001711 active site 167546001712 catalytic residues [active] 167546001713 heterodimer interface [polypeptide binding]; other site 167546001714 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167546001715 YciI-like protein; Reviewed; Region: PRK12864 167546001716 Uncharacterized conserved protein [Function unknown]; Region: COG3339 167546001717 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167546001718 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167546001719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167546001720 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167546001721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167546001722 DNA binding residues [nucleotide binding] 167546001723 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167546001724 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 167546001725 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 167546001726 metal binding site [ion binding]; metal-binding site 167546001727 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167546001728 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167546001729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546001730 Walker A motif; other site 167546001731 ATP binding site [chemical binding]; other site 167546001732 Walker B motif; other site 167546001733 arginine finger; other site 167546001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546001735 Walker A motif; other site 167546001736 ATP binding site [chemical binding]; other site 167546001737 Walker B motif; other site 167546001738 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167546001739 plastocyanin; Provisional; Region: PRK02710 167546001740 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 167546001741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546001742 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167546001743 NAD(P) binding site [chemical binding]; other site 167546001744 active site 167546001745 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 167546001746 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167546001747 substrate binding site [chemical binding]; other site 167546001748 active site 167546001749 glycogen branching enzyme; Provisional; Region: PRK05402 167546001750 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 167546001751 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167546001752 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167546001753 active site 167546001754 catalytic site [active] 167546001755 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 167546001756 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 167546001757 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 167546001758 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167546001759 Protein of function (DUF2518); Region: DUF2518; pfam10726 167546001760 Family of unknown function (DUF490); Region: DUF490; pfam04357 167546001761 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167546001762 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 167546001763 putative catalytic cysteine [active] 167546001764 Dihydroneopterin aldolase; Region: FolB; smart00905 167546001765 active site 167546001766 Lipase (class 2); Region: Lipase_2; pfam01674 167546001767 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167546001768 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167546001769 active site 167546001770 Zn binding site [ion binding]; other site 167546001771 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167546001772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167546001773 homoserine kinase; Provisional; Region: PRK01212 167546001774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167546001775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167546001776 Glucokinase; Region: Glucokinase; pfam02685 167546001777 glucokinase, proteobacterial type; Region: glk; TIGR00749 167546001778 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167546001779 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167546001780 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167546001781 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167546001782 active site 167546001783 dimer interface [polypeptide binding]; other site 167546001784 motif 1; other site 167546001785 motif 2; other site 167546001786 motif 3; other site 167546001787 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167546001788 anticodon binding site; other site 167546001789 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 167546001790 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167546001791 active site 167546001792 HIGH motif; other site 167546001793 dimer interface [polypeptide binding]; other site 167546001794 KMSKS motif; other site 167546001795 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167546001796 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 167546001797 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167546001798 metal binding site [ion binding]; metal-binding site 167546001799 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167546001800 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167546001801 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167546001802 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167546001803 ABC-ATPase subunit interface; other site 167546001804 dimer interface [polypeptide binding]; other site 167546001805 putative PBP binding regions; other site 167546001806 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167546001807 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167546001808 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167546001809 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167546001810 Catalytic site [active] 167546001811 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 167546001812 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167546001813 dimer interface [polypeptide binding]; other site 167546001814 tetramer interface [polypeptide binding]; other site 167546001815 PYR/PP interface [polypeptide binding]; other site 167546001816 TPP binding site [chemical binding]; other site 167546001817 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167546001818 TPP-binding site; other site 167546001819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167546001820 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 167546001821 substrate binding site [chemical binding]; other site 167546001822 oxyanion hole (OAH) forming residues; other site 167546001823 trimer interface [polypeptide binding]; other site 167546001824 glycogen synthase; Provisional; Region: glgA; PRK00654 167546001825 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167546001826 ADP-binding pocket [chemical binding]; other site 167546001827 homodimer interface [polypeptide binding]; other site 167546001828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167546001829 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 167546001830 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167546001831 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 167546001832 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 167546001833 Substrate binding site; other site 167546001834 Mg++ binding site; other site 167546001835 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 167546001836 active site 167546001837 substrate binding site [chemical binding]; other site 167546001838 CoA binding site [chemical binding]; other site 167546001839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001840 S-adenosylmethionine binding site [chemical binding]; other site 167546001841 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 167546001842 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 167546001843 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167546001844 hinge; other site 167546001845 active site 167546001846 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 167546001847 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167546001848 nitrilase; Region: PLN02798 167546001849 putative active site [active] 167546001850 catalytic triad [active] 167546001851 dimer interface [polypeptide binding]; other site 167546001852 AMIN domain; Region: AMIN; pfam11741 167546001853 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 167546001854 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167546001855 active site 167546001856 metal binding site [ion binding]; metal-binding site 167546001857 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 167546001858 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167546001859 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167546001860 substrate binding pocket [chemical binding]; other site 167546001861 chain length determination region; other site 167546001862 substrate-Mg2+ binding site; other site 167546001863 catalytic residues [active] 167546001864 aspartate-rich region 1; other site 167546001865 active site lid residues [active] 167546001866 aspartate-rich region 2; other site 167546001867 acetyl-CoA synthetase; Provisional; Region: PRK00174 167546001868 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 167546001869 active site 167546001870 CoA binding site [chemical binding]; other site 167546001871 acyl-activating enzyme (AAE) consensus motif; other site 167546001872 AMP binding site [chemical binding]; other site 167546001873 acetate binding site [chemical binding]; other site 167546001874 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167546001875 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167546001876 active site 167546001877 catalytic site [active] 167546001878 substrate binding site [chemical binding]; other site 167546001879 GLTT repeat (6 copies); Region: GLTT; pfam01744 167546001880 GLTT repeat (6 copies); Region: GLTT; pfam01744 167546001881 Protein of unknown function; Region: DUF3721; pfam12518 167546001882 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 167546001883 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167546001884 dimer interface [polypeptide binding]; other site 167546001885 motif 1; other site 167546001886 active site 167546001887 motif 2; other site 167546001888 motif 3; other site 167546001889 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 167546001890 anticodon binding site; other site 167546001891 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 167546001892 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167546001893 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 167546001894 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167546001895 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167546001896 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 167546001897 putative N-terminal domain interface [polypeptide binding]; other site 167546001898 putative dimer interface [polypeptide binding]; other site 167546001899 putative substrate binding pocket (H-site) [chemical binding]; other site 167546001900 T5orf172 domain; Region: T5orf172; pfam10544 167546001901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546001902 short chain dehydrogenase; Provisional; Region: PRK07326 167546001903 NAD(P) binding site [chemical binding]; other site 167546001904 active site 167546001905 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167546001906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546001907 protochlorophyllide reductase; Region: PLN00015 167546001908 NAD(P) binding site [chemical binding]; other site 167546001909 active site 167546001910 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 167546001911 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167546001912 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 167546001913 Isochorismatase family; Region: Isochorismatase; pfam00857 167546001914 catalytic triad [active] 167546001915 dimer interface [polypeptide binding]; other site 167546001916 conserved cis-peptide bond; other site 167546001917 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167546001918 metal binding site 2 [ion binding]; metal-binding site 167546001919 putative DNA binding helix; other site 167546001920 metal binding site 1 [ion binding]; metal-binding site 167546001921 dimer interface [polypeptide binding]; other site 167546001922 structural Zn2+ binding site [ion binding]; other site 167546001923 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167546001924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546001925 FeS/SAM binding site; other site 167546001926 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167546001927 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 167546001928 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167546001929 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 167546001930 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167546001931 homodimer interface [polypeptide binding]; other site 167546001932 substrate-cofactor binding pocket; other site 167546001933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546001934 catalytic residue [active] 167546001935 Homoserine O-succinyltransferase; Region: HTS; pfam04204 167546001936 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 167546001937 conserved cys residue [active] 167546001938 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167546001939 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167546001940 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167546001941 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167546001942 FAD binding domain; Region: FAD_binding_4; pfam01565 167546001943 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167546001944 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167546001945 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167546001946 putative active site [active] 167546001947 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167546001948 putative active site [active] 167546001949 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167546001950 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167546001951 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167546001952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546001953 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167546001954 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546001955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167546001956 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 167546001957 dimer interface [polypeptide binding]; other site 167546001958 active site 167546001959 metal binding site [ion binding]; metal-binding site 167546001960 glutathione binding site [chemical binding]; other site 167546001961 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 167546001962 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 167546001963 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 167546001964 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 167546001965 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 167546001966 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 167546001967 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 167546001968 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167546001969 Walker A motif; other site 167546001970 ATP binding site [chemical binding]; other site 167546001971 Walker B motif; other site 167546001972 Type II/IV secretion system protein; Region: T2SE; pfam00437 167546001973 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 167546001974 Walker A motif; other site 167546001975 ATP binding site [chemical binding]; other site 167546001976 Walker B motif; other site 167546001977 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 167546001978 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 167546001979 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 167546001980 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 167546001981 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 167546001982 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 167546001983 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 167546001984 Plasmodium Vir superfamily; Provisional; Region: PTZ00473 167546001985 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 167546001986 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 167546001987 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167546001988 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167546001989 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167546001990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546001991 S-adenosylmethionine binding site [chemical binding]; other site 167546001992 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167546001993 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 167546001994 G1 box; other site 167546001995 putative GEF interaction site [polypeptide binding]; other site 167546001996 GTP/Mg2+ binding site [chemical binding]; other site 167546001997 Switch I region; other site 167546001998 G2 box; other site 167546001999 G3 box; other site 167546002000 Switch II region; other site 167546002001 G4 box; other site 167546002002 G5 box; other site 167546002003 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167546002004 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167546002005 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167546002006 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167546002007 dimerization interface [polypeptide binding]; other site 167546002008 domain crossover interface; other site 167546002009 redox-dependent activation switch; other site 167546002010 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167546002011 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167546002012 Walker A/P-loop; other site 167546002013 ATP binding site [chemical binding]; other site 167546002014 Q-loop/lid; other site 167546002015 ABC transporter signature motif; other site 167546002016 Walker B; other site 167546002017 D-loop; other site 167546002018 H-loop/switch region; other site 167546002019 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167546002020 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 167546002021 Integral membrane protein DUF92; Region: DUF92; pfam01940 167546002022 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167546002023 active site 167546002024 catalytic triad [active] 167546002025 oxyanion hole [active] 167546002026 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167546002027 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167546002028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546002029 Walker A/P-loop; other site 167546002030 ATP binding site [chemical binding]; other site 167546002031 Q-loop/lid; other site 167546002032 ABC transporter signature motif; other site 167546002033 Walker B; other site 167546002034 D-loop; other site 167546002035 H-loop/switch region; other site 167546002036 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167546002037 aspartate aminotransferase; Provisional; Region: PRK05764 167546002038 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167546002039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546002040 homodimer interface [polypeptide binding]; other site 167546002041 catalytic residue [active] 167546002042 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167546002043 active site 167546002044 Fe-S cluster binding site [ion binding]; other site 167546002045 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167546002046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167546002047 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167546002048 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167546002049 C-terminal peptidase (prc); Region: prc; TIGR00225 167546002050 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167546002051 protein binding site [polypeptide binding]; other site 167546002052 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167546002053 Catalytic dyad [active] 167546002054 quinolinate synthetase; Provisional; Region: PRK09375 167546002055 TIGR04168 family protein; Region: TIGR04168 167546002056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167546002057 Repair protein; Region: Repair_PSII; pfam04536 167546002058 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 167546002059 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167546002060 active site 167546002061 dimer interface [polypeptide binding]; other site 167546002062 metal binding site [ion binding]; metal-binding site 167546002063 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167546002064 ATP-grasp domain; Region: ATP-grasp; pfam02222 167546002065 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546002066 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167546002067 Cucumber mosaic virus 1a protein C terminal; Region: CMV_1a_C; pfam12503 167546002068 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167546002069 nucleotide binding pocket [chemical binding]; other site 167546002070 K-X-D-G motif; other site 167546002071 catalytic site [active] 167546002072 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546002073 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 167546002074 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 167546002075 C factor cell-cell signaling protein; Provisional; Region: PRK09009 167546002076 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167546002077 NADP binding site [chemical binding]; other site 167546002078 homodimer interface [polypeptide binding]; other site 167546002079 active site 167546002080 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167546002081 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167546002082 Ion channel; Region: Ion_trans_2; pfam07885 167546002083 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167546002084 TrkA-N domain; Region: TrkA_N; pfam02254 167546002085 TrkA-C domain; Region: TrkA_C; pfam02080 167546002086 Cytochrome c; Region: Cytochrom_C; cl11414 167546002087 PBP superfamily domain; Region: PBP_like_2; cl17296 167546002088 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 167546002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546002090 dimer interface [polypeptide binding]; other site 167546002091 conserved gate region; other site 167546002092 putative PBP binding loops; other site 167546002093 ABC-ATPase subunit interface; other site 167546002094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 167546002095 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 167546002096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546002097 dimer interface [polypeptide binding]; other site 167546002098 conserved gate region; other site 167546002099 putative PBP binding loops; other site 167546002100 ABC-ATPase subunit interface; other site 167546002101 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167546002102 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 167546002103 Walker A/P-loop; other site 167546002104 ATP binding site [chemical binding]; other site 167546002105 Q-loop/lid; other site 167546002106 ABC transporter signature motif; other site 167546002107 Walker B; other site 167546002108 D-loop; other site 167546002109 H-loop/switch region; other site 167546002110 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 167546002111 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167546002112 putative active site [active] 167546002113 putative metal binding site [ion binding]; other site 167546002114 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 167546002115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546002116 ATP binding site [chemical binding]; other site 167546002117 putative Mg++ binding site [ion binding]; other site 167546002118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546002119 nucleotide binding region [chemical binding]; other site 167546002120 ATP-binding site [chemical binding]; other site 167546002121 DEAD/H associated; Region: DEAD_assoc; pfam08494 167546002122 ATP-dependent DNA ligase; Validated; Region: PRK09247 167546002123 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 167546002124 active site 167546002125 DNA binding site [nucleotide binding] 167546002126 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 167546002127 DNA binding site [nucleotide binding] 167546002128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167546002129 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 167546002130 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167546002131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 167546002132 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 167546002133 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 167546002134 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 167546002135 Thf1-like protein; Reviewed; Region: PRK13266 167546002136 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 167546002137 Clp protease; Region: CLP_protease; pfam00574 167546002138 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167546002139 oligomer interface [polypeptide binding]; other site 167546002140 active site residues [active] 167546002141 cell division protein; Validated; Region: ftsH; CHL00176 167546002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546002143 Walker A motif; other site 167546002144 ATP binding site [chemical binding]; other site 167546002145 Walker B motif; other site 167546002146 arginine finger; other site 167546002147 Peptidase family M41; Region: Peptidase_M41; pfam01434 167546002148 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167546002149 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167546002150 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167546002151 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167546002152 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167546002153 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167546002154 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167546002155 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 167546002156 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167546002157 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167546002158 HlyD family secretion protein; Region: HlyD_3; pfam13437 167546002159 DevC protein; Region: devC; TIGR01185 167546002160 FtsX-like permease family; Region: FtsX; pfam02687 167546002161 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167546002162 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167546002163 Walker A/P-loop; other site 167546002164 ATP binding site [chemical binding]; other site 167546002165 Q-loop/lid; other site 167546002166 ABC transporter signature motif; other site 167546002167 Walker B; other site 167546002168 D-loop; other site 167546002169 H-loop/switch region; other site 167546002170 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167546002171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167546002172 active site 167546002173 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167546002174 rRNA interaction site [nucleotide binding]; other site 167546002175 S8 interaction site; other site 167546002176 putative laminin-1 binding site; other site 167546002177 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167546002178 UBA/TS-N domain; Region: UBA; pfam00627 167546002179 Elongation factor TS; Region: EF_TS; pfam00889 167546002180 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167546002181 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167546002182 generic binding surface II; other site 167546002183 ssDNA binding site; other site 167546002184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546002185 ATP binding site [chemical binding]; other site 167546002186 putative Mg++ binding site [ion binding]; other site 167546002187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546002188 nucleotide binding region [chemical binding]; other site 167546002189 ATP-binding site [chemical binding]; other site 167546002190 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 167546002191 sulfite reductase subunit beta; Provisional; Region: PRK13504 167546002192 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167546002193 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167546002194 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167546002195 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167546002196 geranylgeranyl reductase; Region: ChlP; TIGR02028 167546002197 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 167546002198 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 167546002199 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 167546002200 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 167546002201 G1 box; other site 167546002202 putative GEF interaction site [polypeptide binding]; other site 167546002203 GTP/Mg2+ binding site [chemical binding]; other site 167546002204 Switch I region; other site 167546002205 G2 box; other site 167546002206 G3 box; other site 167546002207 Switch II region; other site 167546002208 G4 box; other site 167546002209 G5 box; other site 167546002210 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167546002211 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167546002212 Domain of unknown function (DUF309); Region: DUF309; pfam03745 167546002213 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167546002214 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 167546002215 Walker A/P-loop; other site 167546002216 ATP binding site [chemical binding]; other site 167546002217 Q-loop/lid; other site 167546002218 ABC transporter signature motif; other site 167546002219 Walker B; other site 167546002220 D-loop; other site 167546002221 H-loop/switch region; other site 167546002222 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 167546002223 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167546002224 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 167546002225 substrate binding site [chemical binding]; other site 167546002226 hexamer interface [polypeptide binding]; other site 167546002227 metal binding site [ion binding]; metal-binding site 167546002228 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 167546002229 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167546002230 putative active site [active] 167546002231 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167546002232 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167546002233 tRNA; other site 167546002234 putative tRNA binding site [nucleotide binding]; other site 167546002235 putative NADP binding site [chemical binding]; other site 167546002236 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 167546002237 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167546002238 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167546002239 ligand binding site; other site 167546002240 oligomer interface; other site 167546002241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167546002242 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167546002243 dimer interface [polypeptide binding]; other site 167546002244 N-terminal domain interface [polypeptide binding]; other site 167546002245 sulfate 1 binding site; other site 167546002246 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 167546002247 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167546002248 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167546002249 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 167546002250 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167546002251 putative active site [active] 167546002252 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 167546002253 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 167546002254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167546002255 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167546002256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546002257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546002258 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167546002259 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 167546002260 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167546002261 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 167546002262 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 167546002263 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 167546002264 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167546002265 putative active site [active] 167546002266 catalytic triad [active] 167546002267 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 167546002268 intersubunit interface [polypeptide binding]; other site 167546002269 active site 167546002270 zinc binding site [ion binding]; other site 167546002271 Na+ binding site [ion binding]; other site 167546002272 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167546002273 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167546002274 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167546002275 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167546002276 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 167546002277 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167546002278 active site 167546002279 tartrate dehydrogenase; Region: TTC; TIGR02089 167546002280 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 167546002281 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167546002282 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167546002283 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167546002284 trimer interface [polypeptide binding]; other site 167546002285 active site 167546002286 UDP-GlcNAc binding site [chemical binding]; other site 167546002287 lipid binding site [chemical binding]; lipid-binding site 167546002288 gamma-glutamyl kinase; Provisional; Region: PRK05429 167546002289 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167546002290 nucleotide binding site [chemical binding]; other site 167546002291 homotetrameric interface [polypeptide binding]; other site 167546002292 putative phosphate binding site [ion binding]; other site 167546002293 putative allosteric binding site; other site 167546002294 PUA domain; Region: PUA; pfam01472 167546002295 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 167546002296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167546002297 active site 167546002298 motif I; other site 167546002299 motif II; other site 167546002300 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167546002301 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 167546002302 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 167546002303 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167546002304 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167546002305 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167546002306 catalytic residues [active] 167546002307 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167546002308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546002309 NAD(P) binding site [chemical binding]; other site 167546002310 active site 167546002311 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167546002312 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 167546002313 trimer interface [polypeptide binding]; other site 167546002314 putative Zn binding site [ion binding]; other site 167546002315 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167546002316 GSH binding site [chemical binding]; other site 167546002317 catalytic residues [active] 167546002318 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167546002319 NADH(P)-binding; Region: NAD_binding_10; pfam13460 167546002320 NAD(P) binding site [chemical binding]; other site 167546002321 putative active site [active] 167546002322 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167546002323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167546002324 minor groove reading motif; other site 167546002325 helix-hairpin-helix signature motif; other site 167546002326 substrate binding pocket [chemical binding]; other site 167546002327 active site 167546002328 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167546002329 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 167546002330 Walker A/P-loop; other site 167546002331 ATP binding site [chemical binding]; other site 167546002332 Q-loop/lid; other site 167546002333 ABC transporter signature motif; other site 167546002334 Walker B; other site 167546002335 D-loop; other site 167546002336 H-loop/switch region; other site 167546002337 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167546002338 Ferritin-like domain; Region: Ferritin; pfam00210 167546002339 ferroxidase diiron center [ion binding]; other site 167546002340 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167546002341 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167546002342 putative switch regulator; other site 167546002343 non-specific DNA interactions [nucleotide binding]; other site 167546002344 DNA binding site [nucleotide binding] 167546002345 sequence specific DNA binding site [nucleotide binding]; other site 167546002346 putative cAMP binding site [chemical binding]; other site 167546002347 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167546002348 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 167546002349 Walker A/P-loop; other site 167546002350 ATP binding site [chemical binding]; other site 167546002351 Q-loop/lid; other site 167546002352 ABC transporter signature motif; other site 167546002353 Walker B; other site 167546002354 D-loop; other site 167546002355 H-loop/switch region; other site 167546002356 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 167546002357 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167546002358 [2Fe-2S] cluster binding site [ion binding]; other site 167546002359 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167546002360 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 167546002361 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 167546002362 Walker A/P-loop; other site 167546002363 ATP binding site [chemical binding]; other site 167546002364 Q-loop/lid; other site 167546002365 ABC transporter signature motif; other site 167546002366 Walker B; other site 167546002367 D-loop; other site 167546002368 H-loop/switch region; other site 167546002369 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 167546002370 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 167546002371 Walker A/P-loop; other site 167546002372 ATP binding site [chemical binding]; other site 167546002373 Q-loop/lid; other site 167546002374 ABC transporter signature motif; other site 167546002375 Walker B; other site 167546002376 D-loop; other site 167546002377 H-loop/switch region; other site 167546002378 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 167546002379 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 167546002380 TM-ABC transporter signature motif; other site 167546002381 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 167546002382 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 167546002383 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 167546002384 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 167546002385 putative ligand binding site [chemical binding]; other site 167546002386 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167546002387 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 167546002388 UreF; Region: UreF; pfam01730 167546002389 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 167546002390 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 167546002391 dimer interface [polypeptide binding]; other site 167546002392 catalytic residues [active] 167546002393 UreD urease accessory protein; Region: UreD; pfam01774 167546002394 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 167546002395 alpha-gamma subunit interface [polypeptide binding]; other site 167546002396 beta-gamma subunit interface [polypeptide binding]; other site 167546002397 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 167546002398 alpha-beta subunit interface [polypeptide binding]; other site 167546002399 urease subunit alpha; Reviewed; Region: ureC; PRK13207 167546002400 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 167546002401 subunit interactions [polypeptide binding]; other site 167546002402 active site 167546002403 flap region; other site 167546002404 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 167546002405 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167546002406 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 167546002407 active site 167546002408 homodimer interface [polypeptide binding]; other site 167546002409 catalytic site [active] 167546002410 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 167546002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167546002412 active site 167546002413 motif I; other site 167546002414 motif II; other site 167546002415 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167546002416 active site 167546002417 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 167546002418 Bacitracin resistance protein BacA; Region: BacA; pfam02673 167546002419 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167546002420 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167546002421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167546002422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546002423 Walker A/P-loop; other site 167546002424 ATP binding site [chemical binding]; other site 167546002425 Q-loop/lid; other site 167546002426 ABC transporter signature motif; other site 167546002427 Walker B; other site 167546002428 D-loop; other site 167546002429 H-loop/switch region; other site 167546002430 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167546002431 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167546002432 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167546002433 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167546002434 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167546002435 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 167546002436 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167546002437 catalytic site [active] 167546002438 subunit interface [polypeptide binding]; other site 167546002439 similar to hypothetical protein 167546002440 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167546002441 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167546002442 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 167546002443 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167546002444 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167546002445 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 167546002446 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 167546002447 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167546002448 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 167546002449 active site 167546002450 PHP Thumb interface [polypeptide binding]; other site 167546002451 metal binding site [ion binding]; metal-binding site 167546002452 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167546002453 generic binding surface I; other site 167546002454 generic binding surface II; other site 167546002455 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167546002456 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167546002457 16S/18S rRNA binding site [nucleotide binding]; other site 167546002458 S13e-L30e interaction site [polypeptide binding]; other site 167546002459 25S rRNA binding site [nucleotide binding]; other site 167546002460 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167546002461 RuvA N terminal domain; Region: RuvA_N; pfam01330 167546002462 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167546002463 EamA-like transporter family; Region: EamA; pfam00892 167546002464 DNA primase; Validated; Region: dnaG; PRK05667 167546002465 CHC2 zinc finger; Region: zf-CHC2; pfam01807 167546002466 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167546002467 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167546002468 active site 167546002469 metal binding site [ion binding]; metal-binding site 167546002470 interdomain interaction site; other site 167546002471 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167546002472 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167546002473 active site 167546002474 DNA binding site [nucleotide binding] 167546002475 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 167546002476 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 167546002477 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167546002478 Catalytic site [active] 167546002479 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 167546002480 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 167546002481 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 167546002482 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167546002483 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167546002484 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167546002485 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167546002486 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167546002487 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167546002488 alpha subunit interface [polypeptide binding]; other site 167546002489 TPP binding site [chemical binding]; other site 167546002490 heterodimer interface [polypeptide binding]; other site 167546002491 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167546002492 protein-export membrane protein SecD; Region: secD; TIGR01129 167546002493 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 167546002494 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 167546002495 Protein export membrane protein; Region: SecD_SecF; cl14618 167546002496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 167546002497 Domain of unknown function DUF20; Region: UPF0118; pfam01594 167546002498 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 167546002499 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 167546002500 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 167546002501 active site residue [active] 167546002502 GUN4-like; Region: GUN4; pfam05419 167546002503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167546002504 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 167546002505 ATP binding site [chemical binding]; other site 167546002506 Mg2+ binding site [ion binding]; other site 167546002507 G-X-G motif; other site 167546002508 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167546002509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546002510 S-adenosylmethionine binding site [chemical binding]; other site 167546002511 glutamine synthetase, type I; Region: GlnA; TIGR00653 167546002512 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167546002513 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167546002514 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167546002515 homodimer interface [polypeptide binding]; other site 167546002516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546002517 catalytic residue [active] 167546002518 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167546002519 nucleoside/Zn binding site; other site 167546002520 dimer interface [polypeptide binding]; other site 167546002521 catalytic motif [active] 167546002522 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546002523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546002524 catalytic residue [active] 167546002525 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167546002526 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 167546002527 G1 box; other site 167546002528 GTP/Mg2+ binding site [chemical binding]; other site 167546002529 G2 box; other site 167546002530 Switch I region; other site 167546002531 G3 box; other site 167546002532 Switch II region; other site 167546002533 G4 box; other site 167546002534 G5 box; other site 167546002535 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167546002536 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 167546002537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167546002538 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167546002539 FtsX-like permease family; Region: FtsX; pfam02687 167546002540 pyruvate kinase; Provisional; Region: PRK06354 167546002541 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 167546002542 domain interfaces; other site 167546002543 active site 167546002544 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 167546002545 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 167546002546 putative metal binding site [ion binding]; other site 167546002547 YGGT family; Region: YGGT; pfam02325 167546002548 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 167546002549 threonine dehydratase; Reviewed; Region: PRK09224 167546002550 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167546002551 tetramer interface [polypeptide binding]; other site 167546002552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546002553 catalytic residue [active] 167546002554 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167546002555 putative Ile/Val binding site [chemical binding]; other site 167546002556 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167546002557 putative Ile/Val binding site [chemical binding]; other site 167546002558 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167546002559 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167546002560 TPP-binding site; other site 167546002561 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167546002562 PYR/PP interface [polypeptide binding]; other site 167546002563 dimer interface [polypeptide binding]; other site 167546002564 TPP binding site [chemical binding]; other site 167546002565 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167546002566 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 167546002567 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167546002568 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167546002569 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167546002570 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 167546002571 catalytic triad [active] 167546002572 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 167546002573 heat shock protein 90; Provisional; Region: PRK05218 167546002574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546002575 ATP binding site [chemical binding]; other site 167546002576 Mg2+ binding site [ion binding]; other site 167546002577 G-X-G motif; other site 167546002578 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167546002579 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167546002580 motif 1; other site 167546002581 dimer interface [polypeptide binding]; other site 167546002582 active site 167546002583 motif 3; other site 167546002584 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167546002585 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167546002586 active site 167546002587 dimerization interface [polypeptide binding]; other site 167546002588 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167546002589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167546002590 catalytic loop [active] 167546002591 iron binding site [ion binding]; other site 167546002592 molecular chaperone DnaK; Provisional; Region: PRK13410 167546002593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167546002594 nucleotide binding site [chemical binding]; other site 167546002595 chaperone protein DnaJ; Provisional; Region: PRK14299 167546002596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167546002597 HSP70 interaction site [polypeptide binding]; other site 167546002598 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167546002599 substrate binding site [polypeptide binding]; other site 167546002600 dimer interface [polypeptide binding]; other site 167546002601 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167546002602 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167546002603 active site 167546002604 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167546002605 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 167546002606 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167546002607 dimerization interface [polypeptide binding]; other site 167546002608 active site 167546002609 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167546002610 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167546002611 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 167546002612 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167546002613 active site 167546002614 substrate binding site [chemical binding]; other site 167546002615 cosubstrate binding site; other site 167546002616 catalytic site [active] 167546002617 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167546002618 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 167546002619 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167546002620 dimer interface [polypeptide binding]; other site 167546002621 active site 167546002622 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167546002623 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167546002624 HIGH motif; other site 167546002625 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167546002626 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167546002627 active site 167546002628 KMSKS motif; other site 167546002629 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167546002630 tRNA binding surface [nucleotide binding]; other site 167546002631 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167546002632 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167546002633 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167546002634 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167546002635 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546002636 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 167546002637 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546002638 catalytic residue [active] 167546002639 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167546002640 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167546002641 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 167546002642 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167546002643 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 167546002644 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167546002645 active site 167546002646 (T/H)XGH motif; other site 167546002647 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 167546002648 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167546002649 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167546002650 GIY-YIG motif/motif A; other site 167546002651 active site 167546002652 catalytic site [active] 167546002653 putative DNA binding site [nucleotide binding]; other site 167546002654 metal binding site [ion binding]; metal-binding site 167546002655 UvrB/uvrC motif; Region: UVR; pfam02151 167546002656 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167546002657 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 167546002658 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 167546002659 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 167546002660 active site 167546002661 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 167546002662 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167546002663 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 167546002664 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167546002665 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167546002666 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167546002667 homodimer interface [polypeptide binding]; other site 167546002668 substrate-cofactor binding pocket; other site 167546002669 catalytic residue [active] 167546002670 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 167546002671 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167546002672 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 167546002673 substrate binding pocket [chemical binding]; other site 167546002674 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167546002675 B12 binding site [chemical binding]; other site 167546002676 cobalt ligand [ion binding]; other site 167546002677 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167546002678 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 167546002679 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167546002680 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167546002681 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167546002682 HSP70 interaction site [polypeptide binding]; other site 167546002683 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167546002684 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167546002685 putative tRNA-binding site [nucleotide binding]; other site 167546002686 B3/4 domain; Region: B3_4; pfam03483 167546002687 tRNA synthetase B5 domain; Region: B5; smart00874 167546002688 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167546002689 dimer interface [polypeptide binding]; other site 167546002690 motif 1; other site 167546002691 motif 3; other site 167546002692 motif 2; other site 167546002693 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 167546002694 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 167546002695 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 167546002696 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167546002697 RNB domain; Region: RNB; pfam00773 167546002698 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167546002699 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167546002700 active site 167546002701 HIGH motif; other site 167546002702 KMSKS motif; other site 167546002703 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167546002704 tRNA binding surface [nucleotide binding]; other site 167546002705 anticodon binding site; other site 167546002706 Protein involved in vacuole import and degradation [Intracellular trafficking and secretion]; Region: VID27; COG5167 167546002707 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167546002708 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167546002709 homotrimer interface [polypeptide binding]; other site 167546002710 Walker A motif; other site 167546002711 GTP binding site [chemical binding]; other site 167546002712 Walker B motif; other site 167546002713 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 167546002714 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 167546002715 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546002716 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167546002717 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167546002718 dimer interface [polypeptide binding]; other site 167546002719 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167546002720 catalytic triad [active] 167546002721 peroxidatic and resolving cysteines [active] 167546002722 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167546002723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546002724 Walker A motif; other site 167546002725 ATP binding site [chemical binding]; other site 167546002726 Walker B motif; other site 167546002727 arginine finger; other site 167546002728 Peptidase family M41; Region: Peptidase_M41; pfam01434 167546002729 ribosomal protein L32; Validated; Region: rpl32; CHL00152 167546002730 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 167546002731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167546002732 motif II; other site 167546002733 Flagellin N-methylase; Region: FliB; pfam03692 167546002734 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167546002735 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167546002736 Predicted membrane protein [Function unknown]; Region: COG2119 167546002737 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 167546002738 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167546002739 RNB domain; Region: RNB; pfam00773 167546002740 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 167546002741 RNA binding site [nucleotide binding]; other site 167546002742 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167546002743 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 167546002744 diiron binding motif [ion binding]; other site 167546002745 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167546002746 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167546002747 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167546002748 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167546002749 putative active site [active] 167546002750 substrate binding site [chemical binding]; other site 167546002751 putative cosubstrate binding site; other site 167546002752 catalytic site [active] 167546002753 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 167546002754 substrate binding site [chemical binding]; other site 167546002755 Integral membrane protein TerC family; Region: TerC; cl10468 167546002756 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167546002757 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 167546002758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546002759 ATP binding site [chemical binding]; other site 167546002760 putative Mg++ binding site [ion binding]; other site 167546002761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546002762 nucleotide binding region [chemical binding]; other site 167546002763 ATP-binding site [chemical binding]; other site 167546002764 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 167546002765 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167546002766 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167546002767 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167546002768 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 167546002769 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 167546002770 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167546002771 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 167546002772 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167546002773 magnesium chelatase subunit H; Provisional; Region: PRK12493 167546002774 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 167546002775 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167546002776 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167546002777 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167546002778 dihydropteroate synthase; Region: DHPS; TIGR01496 167546002779 substrate binding pocket [chemical binding]; other site 167546002780 dimer interface [polypeptide binding]; other site 167546002781 inhibitor binding site; inhibition site 167546002782 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167546002783 triosephosphate isomerase; Provisional; Region: PRK14565 167546002784 substrate binding site [chemical binding]; other site 167546002785 dimer interface [polypeptide binding]; other site 167546002786 catalytic triad [active] 167546002787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546002788 RNA binding surface [nucleotide binding]; other site 167546002789 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 167546002790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167546002791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546002792 Walker A/P-loop; other site 167546002793 ATP binding site [chemical binding]; other site 167546002794 Q-loop/lid; other site 167546002795 ABC transporter signature motif; other site 167546002796 Walker B; other site 167546002797 D-loop; other site 167546002798 H-loop/switch region; other site 167546002799 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167546002800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167546002801 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167546002802 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 167546002803 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167546002804 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167546002805 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167546002806 IMP binding site; other site 167546002807 dimer interface [polypeptide binding]; other site 167546002808 interdomain contacts; other site 167546002809 partial ornithine binding site; other site 167546002810 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167546002811 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 167546002812 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167546002813 L-asparaginase II; Region: Asparaginase_II; pfam06089 167546002814 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167546002815 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 167546002816 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 167546002817 Walker A/P-loop; other site 167546002818 ATP binding site [chemical binding]; other site 167546002819 Q-loop/lid; other site 167546002820 ABC transporter signature motif; other site 167546002821 Walker B; other site 167546002822 D-loop; other site 167546002823 H-loop/switch region; other site 167546002824 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 167546002825 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167546002826 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167546002827 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167546002828 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167546002829 active site 167546002830 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 167546002831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546002832 active site 167546002833 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 167546002834 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 167546002835 ski2-like helicase; Provisional; Region: PRK00254 167546002836 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167546002837 active site 167546002838 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 167546002839 active site pocket [active] 167546002840 oxyanion hole [active] 167546002841 catalytic triad [active] 167546002842 active site nucleophile [active] 167546002843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167546002844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167546002845 Coenzyme A binding pocket [chemical binding]; other site 167546002846 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167546002847 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167546002848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167546002849 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167546002850 aminopeptidase N; Provisional; Region: pepN; PRK14015 167546002851 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 167546002852 Zn binding site [ion binding]; other site 167546002853 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167546002854 ATP-grasp domain; Region: ATP-grasp; pfam02222 167546002855 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167546002856 catalytic residues [active] 167546002857 dimer interface [polypeptide binding]; other site 167546002858 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 167546002859 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167546002860 FMN binding site [chemical binding]; other site 167546002861 active site 167546002862 catalytic residues [active] 167546002863 substrate binding site [chemical binding]; other site 167546002864 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167546002865 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167546002866 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167546002867 active site 167546002868 Restriction endonuclease; Region: Mrr_cat; pfam04471 167546002869 MAPEG family; Region: MAPEG; pfam01124 167546002870 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 167546002871 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167546002872 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167546002873 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167546002874 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 167546002875 OsmC-like protein; Region: OsmC; pfam02566 167546002876 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167546002877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 167546002878 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167546002879 dimer interface [polypeptide binding]; other site 167546002880 putative PBP binding regions; other site 167546002881 ABC-ATPase subunit interface; other site 167546002882 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167546002883 metal binding site 2 [ion binding]; metal-binding site 167546002884 putative DNA binding helix; other site 167546002885 metal binding site 1 [ion binding]; metal-binding site 167546002886 dimer interface [polypeptide binding]; other site 167546002887 structural Zn2+ binding site [ion binding]; other site 167546002888 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167546002889 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167546002890 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167546002891 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167546002892 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 167546002893 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167546002894 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167546002895 P-loop, Walker A motif; other site 167546002896 Base recognition motif; other site 167546002897 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167546002898 PQQ-like domain; Region: PQQ_2; pfam13360 167546002899 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 167546002900 structural tetrad; other site 167546002901 Transcription initiation factor IIE; Region: TFIIE; smart00531 167546002902 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 167546002903 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 167546002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 167546002905 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 167546002906 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 167546002907 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 167546002908 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167546002909 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546002910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546002911 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 167546002912 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167546002913 substrate binding site [chemical binding]; other site 167546002914 ATP binding site [chemical binding]; other site 167546002915 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167546002916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167546002917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167546002918 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167546002919 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167546002920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546002921 dimer interface [polypeptide binding]; other site 167546002922 conserved gate region; other site 167546002923 ABC-ATPase subunit interface; other site 167546002924 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 167546002925 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 167546002926 homoserine dehydrogenase; Provisional; Region: PRK06349 167546002927 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 167546002928 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167546002929 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167546002930 Fe-S metabolism associated domain; Region: SufE; cl00951 167546002931 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 167546002932 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 167546002933 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 167546002934 active site 167546002935 putative DNA-binding cleft [nucleotide binding]; other site 167546002936 dimer interface [polypeptide binding]; other site 167546002937 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 167546002938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 167546002939 Walker A motif; other site 167546002940 ATP binding site [chemical binding]; other site 167546002941 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167546002942 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167546002943 Cytochrome c; Region: Cytochrom_C; pfam00034 167546002944 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 167546002945 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 167546002946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546002947 S-adenosylmethionine binding site [chemical binding]; other site 167546002948 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167546002949 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167546002950 putative active site [active] 167546002951 oxyanion strand; other site 167546002952 catalytic triad [active] 167546002953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167546002954 catalytic residues [active] 167546002955 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167546002956 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 167546002957 phosphate binding site [ion binding]; other site 167546002958 DNA gyrase subunit A; Validated; Region: PRK05560 167546002959 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167546002960 CAP-like domain; other site 167546002961 active site 167546002962 primary dimer interface [polypeptide binding]; other site 167546002963 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002964 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167546002969 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167546002970 lycopene cyclase; Region: lycopene_cycl; TIGR01789 167546002971 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167546002972 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 167546002973 active site 167546002974 substrate binding site [chemical binding]; other site 167546002975 catalytic site [active] 167546002976 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167546002977 2-isopropylmalate synthase; Validated; Region: PRK00915 167546002978 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167546002979 active site 167546002980 catalytic residues [active] 167546002981 metal binding site [ion binding]; metal-binding site 167546002982 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 167546002983 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167546002984 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167546002985 Zn2+ binding site [ion binding]; other site 167546002986 Mg2+ binding site [ion binding]; other site 167546002987 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167546002988 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167546002989 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167546002990 homodimer interface [polypeptide binding]; other site 167546002991 NADP binding site [chemical binding]; other site 167546002992 substrate binding site [chemical binding]; other site 167546002993 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167546002994 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167546002995 substrate binding pocket [chemical binding]; other site 167546002996 chain length determination region; other site 167546002997 substrate-Mg2+ binding site; other site 167546002998 catalytic residues [active] 167546002999 aspartate-rich region 1; other site 167546003000 active site lid residues [active] 167546003001 aspartate-rich region 2; other site 167546003002 Divergent PAP2 family; Region: DUF212; pfam02681 167546003003 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167546003004 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 167546003005 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167546003006 catalytic triad [active] 167546003007 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 167546003008 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167546003009 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167546003010 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167546003011 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167546003012 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167546003013 dimerization interface [polypeptide binding]; other site 167546003014 FAD binding pocket [chemical binding]; other site 167546003015 FAD binding motif [chemical binding]; other site 167546003016 catalytic residues [active] 167546003017 NAD binding pocket [chemical binding]; other site 167546003018 phosphate binding motif [ion binding]; other site 167546003019 beta-alpha-beta structure motif; other site 167546003020 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167546003021 hydrophobic ligand binding site; other site 167546003022 adaptive-response sensory kinase; Validated; Region: PRK09303 167546003023 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167546003024 tetramer interface [polypeptide binding]; other site 167546003025 dimer interface [polypeptide binding]; other site 167546003026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167546003027 dimer interface [polypeptide binding]; other site 167546003028 phosphorylation site [posttranslational modification] 167546003029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546003030 ATP binding site [chemical binding]; other site 167546003031 Mg2+ binding site [ion binding]; other site 167546003032 G-X-G motif; other site 167546003033 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 167546003034 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 167546003035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546003036 active site 167546003037 4-alpha-glucanotransferase; Provisional; Region: PRK14508 167546003038 Helix-turn-helix domain; Region: HTH_25; pfam13413 167546003039 non-specific DNA binding site [nucleotide binding]; other site 167546003040 salt bridge; other site 167546003041 sequence-specific DNA binding site [nucleotide binding]; other site 167546003042 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167546003043 ABC1 family; Region: ABC1; cl17513 167546003044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546003045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546003046 catalytic residue [active] 167546003047 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 167546003048 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 167546003049 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 167546003050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167546003051 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 167546003052 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167546003053 putative active site [active] 167546003054 metal binding site [ion binding]; metal-binding site 167546003055 Clp protease ATP binding subunit; Region: clpC; CHL00095 167546003056 Clp amino terminal domain; Region: Clp_N; pfam02861 167546003057 Clp amino terminal domain; Region: Clp_N; pfam02861 167546003058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546003059 Walker A motif; other site 167546003060 ATP binding site [chemical binding]; other site 167546003061 Walker B motif; other site 167546003062 arginine finger; other site 167546003063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546003064 Walker A motif; other site 167546003065 ATP binding site [chemical binding]; other site 167546003066 Walker B motif; other site 167546003067 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167546003068 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167546003069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 167546003070 Coenzyme A binding pocket [chemical binding]; other site 167546003071 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167546003072 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167546003073 active site 167546003074 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167546003075 substrate binding site [chemical binding]; other site 167546003076 catalytic residues [active] 167546003077 dimer interface [polypeptide binding]; other site 167546003078 TIGR00159 family protein; Region: TIGR00159 167546003079 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167546003080 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14831 167546003081 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 167546003082 catalytic residue [active] 167546003083 putative FPP diphosphate binding site; other site 167546003084 putative FPP binding hydrophobic cleft; other site 167546003085 dimer interface [polypeptide binding]; other site 167546003086 putative IPP diphosphate binding site; other site 167546003087 biotin synthase; Region: bioB; TIGR00433 167546003088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546003089 FeS/SAM binding site; other site 167546003090 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 167546003091 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167546003092 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167546003093 active site residue [active] 167546003094 lipoyl synthase; Provisional; Region: PRK12928 167546003095 recombination protein RecR; Reviewed; Region: recR; PRK00076 167546003096 RecR protein; Region: RecR; pfam02132 167546003097 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167546003098 putative active site [active] 167546003099 putative metal-binding site [ion binding]; other site 167546003100 tetramer interface [polypeptide binding]; other site 167546003101 PsbP; Region: PsbP; pfam01789 167546003102 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167546003103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167546003104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546003105 Walker A/P-loop; other site 167546003106 ATP binding site [chemical binding]; other site 167546003107 Q-loop/lid; other site 167546003108 ABC transporter signature motif; other site 167546003109 Walker B; other site 167546003110 D-loop; other site 167546003111 H-loop/switch region; other site 167546003112 helicase 45; Provisional; Region: PTZ00424 167546003113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167546003114 ATP binding site [chemical binding]; other site 167546003115 Mg++ binding site [ion binding]; other site 167546003116 motif III; other site 167546003117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546003118 nucleotide binding region [chemical binding]; other site 167546003119 ATP-binding site [chemical binding]; other site 167546003120 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167546003121 AAA domain; Region: AAA_30; pfam13604 167546003122 Family description; Region: UvrD_C_2; pfam13538 167546003123 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 167546003124 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 167546003125 Phospholipid methyltransferase; Region: PEMT; cl17370 167546003126 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 167546003127 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 167546003128 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 167546003129 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 167546003130 active site 167546003131 hydrophilic channel; other site 167546003132 dimerization interface [polypeptide binding]; other site 167546003133 catalytic residues [active] 167546003134 active site lid [active] 167546003135 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167546003136 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167546003137 putative acyl-acceptor binding pocket; other site 167546003138 BolA-like protein; Region: BolA; pfam01722 167546003139 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167546003140 putative GSH binding site [chemical binding]; other site 167546003141 catalytic residues [active] 167546003142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167546003143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546003144 active site 167546003145 phosphorylation site [posttranslational modification] 167546003146 dimerization interface [polypeptide binding]; other site 167546003147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167546003148 DNA binding site [nucleotide binding] 167546003149 carotene isomerase; Region: carot_isom; TIGR02730 167546003150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167546003151 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167546003152 Glucose inhibited division protein A; Region: GIDA; pfam01134 167546003153 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 167546003154 putative high light inducible protein; Region: PHA02337 167546003155 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 167546003156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 167546003157 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 167546003158 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 167546003159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 167546003160 dimerization interface [polypeptide binding]; other site 167546003161 putative DNA binding site [nucleotide binding]; other site 167546003162 putative Zn2+ binding site [ion binding]; other site 167546003163 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167546003164 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167546003165 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167546003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167546003167 putative substrate translocation pore; other site 167546003168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167546003169 Chromate transporter; Region: Chromate_transp; pfam02417 167546003170 Chromate transporter; Region: Chromate_transp; pfam02417 167546003171 PBP superfamily domain; Region: PBP_like_2; cl17296 167546003172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 167546003173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167546003174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167546003175 dimer interface [polypeptide binding]; other site 167546003176 phosphorylation site [posttranslational modification] 167546003177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546003178 ATP binding site [chemical binding]; other site 167546003179 Mg2+ binding site [ion binding]; other site 167546003180 G-X-G motif; other site 167546003181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167546003182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546003183 active site 167546003184 phosphorylation site [posttranslational modification] 167546003185 intermolecular recognition site; other site 167546003186 dimerization interface [polypeptide binding]; other site 167546003187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167546003188 DNA binding site [nucleotide binding] 167546003189 hypothetical protein; Provisional; Region: PRK11627 167546003190 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167546003191 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 167546003192 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 167546003193 Walker A/P-loop; other site 167546003194 ATP binding site [chemical binding]; other site 167546003195 Q-loop/lid; other site 167546003196 ABC transporter signature motif; other site 167546003197 Walker B; other site 167546003198 D-loop; other site 167546003199 H-loop/switch region; other site 167546003200 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167546003201 PBP superfamily domain; Region: PBP_like; cl17867 167546003202 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167546003203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167546003204 dimer interface [polypeptide binding]; other site 167546003205 conserved gate region; other site 167546003206 ABC-ATPase subunit interface; other site 167546003207 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 167546003208 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 167546003209 homodimer interface [polypeptide binding]; other site 167546003210 ligand binding site [chemical binding]; other site 167546003211 NAD binding site [chemical binding]; other site 167546003212 catalytic site [active] 167546003213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167546003214 Coenzyme A binding pocket [chemical binding]; other site 167546003215 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 167546003216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167546003217 Zn2+ binding site [ion binding]; other site 167546003218 Mg2+ binding site [ion binding]; other site 167546003219 OsmC-like protein; Region: OsmC; cl00767 167546003220 OsmC-like protein; Region: OsmC; pfam02566 167546003221 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 167546003222 Sodium Bile acid symporter family; Region: SBF; cl17470 167546003223 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 167546003224 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 167546003225 Bacterial Ig-like domain; Region: Big_5; pfam13205 167546003226 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 167546003227 Autotransporter beta-domain; Region: Autotransporter; smart00869 167546003228 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546003229 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167546003230 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 167546003231 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 167546003232 L-aspartate oxidase; Provisional; Region: PRK06175 167546003233 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 167546003234 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167546003235 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167546003236 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167546003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546003238 RNA binding surface [nucleotide binding]; other site 167546003239 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 167546003240 probable active site [active] 167546003241 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546003242 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 167546003243 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167546003244 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546003245 potassium and/or sodium efflux P-type ATPase, fungal-type; Region: ATPase-IID_K-Na; TIGR01523 167546003246 Protein of unknown function, DUF; Region: DUF411; cl01142 167546003247 Protein of unknown function; Region: DUF3721; pfam12518 167546003248 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167546003249 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167546003250 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 167546003251 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167546003252 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 167546003253 Na2 binding site [ion binding]; other site 167546003254 putative substrate binding site 1 [chemical binding]; other site 167546003255 Na binding site 1 [ion binding]; other site 167546003256 putative substrate binding site 2 [chemical binding]; other site 167546003257 Uncharacterized conserved protein [Function unknown]; Region: COG0397 167546003258 hypothetical protein; Validated; Region: PRK00029 167546003259 Cupin domain; Region: Cupin_2; pfam07883 167546003260 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546003261 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167546003262 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167546003263 catalytic triad [active] 167546003264 putative high light inducible protein; Region: PHA02337 167546003265 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 167546003266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167546003267 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 167546003268 Predicted amidohydrolase [General function prediction only]; Region: COG0388 167546003269 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 167546003270 putative active site [active] 167546003271 catalytic triad [active] 167546003272 putative dimer interface [polypeptide binding]; other site 167546003273 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 167546003274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546003275 FeS/SAM binding site; other site 167546003276 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 167546003277 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 167546003278 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 167546003279 dimerization interface [polypeptide binding]; other site 167546003280 putative ATP binding site [chemical binding]; other site 167546003281 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 167546003282 putative high light inducible protein; Region: PHA02337 167546003283 putative high light inducible protein; Region: PHA02337 167546003284 putative high light inducible protein; Region: PHA02337 167546003285 GTP-binding protein YchF; Reviewed; Region: PRK09601 167546003286 YchF GTPase; Region: YchF; cd01900 167546003287 G1 box; other site 167546003288 GTP/Mg2+ binding site [chemical binding]; other site 167546003289 Switch I region; other site 167546003290 G2 box; other site 167546003291 Switch II region; other site 167546003292 G3 box; other site 167546003293 G4 box; other site 167546003294 G5 box; other site 167546003295 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167546003296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167546003297 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167546003298 HlyD family secretion protein; Region: HlyD_3; pfam13437 167546003299 DNA polymerase I; Provisional; Region: PRK05755 167546003300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167546003301 active site 167546003302 metal binding site 1 [ion binding]; metal-binding site 167546003303 putative 5' ssDNA interaction site; other site 167546003304 metal binding site 3; metal-binding site 167546003305 metal binding site 2 [ion binding]; metal-binding site 167546003306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167546003307 putative DNA binding site [nucleotide binding]; other site 167546003308 putative metal binding site [ion binding]; other site 167546003309 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167546003310 active site 167546003311 catalytic site [active] 167546003312 substrate binding site [chemical binding]; other site 167546003313 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167546003314 active site 167546003315 DNA binding site [nucleotide binding] 167546003316 catalytic site [active] 167546003317 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167546003318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167546003319 active site 167546003320 HIGH motif; other site 167546003321 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167546003322 KMSKS motif; other site 167546003323 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167546003324 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167546003325 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167546003326 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167546003327 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 167546003328 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 167546003329 dimer interface [polypeptide binding]; other site 167546003330 [2Fe-2S] cluster binding site [ion binding]; other site 167546003331 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167546003332 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 167546003333 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167546003334 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167546003335 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 167546003336 ligand binding site [chemical binding]; other site 167546003337 homodimer interface [polypeptide binding]; other site 167546003338 NAD(P) binding site [chemical binding]; other site 167546003339 trimer interface B [polypeptide binding]; other site 167546003340 trimer interface A [polypeptide binding]; other site 167546003341 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 167546003342 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167546003343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167546003344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167546003345 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167546003346 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167546003347 rRNA binding site [nucleotide binding]; other site 167546003348 predicted 30S ribosome binding site; other site 167546003349 Ycf39; Provisional; Region: ycf39; CHL00194 167546003350 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167546003351 NAD(P) binding site [chemical binding]; other site 167546003352 putative active site [active] 167546003353 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 167546003354 hydrolase, alpha/beta fold family protein; Region: PLN02824 167546003355 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 167546003356 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167546003357 putative valine binding site [chemical binding]; other site 167546003358 dimer interface [polypeptide binding]; other site 167546003359 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167546003360 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 167546003361 active site 167546003362 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 167546003363 photosystem II protein D2; Region: psbD; CHL00004 167546003364 pheophytin binding site; other site 167546003365 chlorophyll binding site; other site 167546003366 quinone binding site; other site 167546003367 Fe binding site [ion binding]; other site 167546003368 Photosystem II protein; Region: PSII; cl08223 167546003369 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 167546003370 Maf-like protein; Region: Maf; pfam02545 167546003371 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167546003372 active site 167546003373 dimer interface [polypeptide binding]; other site 167546003374 cobyric acid synthase; Provisional; Region: PRK00784 167546003375 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167546003376 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167546003377 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167546003378 catalytic triad [active] 167546003379 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167546003380 catalytic loop [active] 167546003381 iron binding site [ion binding]; other site 167546003382 Rhomboid family; Region: Rhomboid; cl11446 167546003383 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 167546003384 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 167546003385 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 167546003386 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 167546003387 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 167546003388 dimer interface [polypeptide binding]; other site 167546003389 active site 167546003390 motif 2; other site 167546003391 motif 3; other site 167546003392 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167546003393 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 167546003394 Methyltransferase domain; Region: Methyltransf_11; pfam08241 167546003395 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167546003396 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167546003397 flavodoxin FldA; Validated; Region: PRK09267 167546003398 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167546003399 Membrane transport protein; Region: Mem_trans; cl09117 167546003400 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167546003401 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 167546003402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167546003403 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 167546003404 putative ADP-binding pocket [chemical binding]; other site 167546003405 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167546003406 EamA-like transporter family; Region: EamA; pfam00892 167546003407 EamA-like transporter family; Region: EamA; pfam00892 167546003408 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 167546003409 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167546003410 tandem repeat interface [polypeptide binding]; other site 167546003411 oligomer interface [polypeptide binding]; other site 167546003412 active site residues [active] 167546003413 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167546003414 active site 167546003415 homotrimer interaction site [polypeptide binding]; other site 167546003416 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167546003417 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 167546003418 Bacterial PH domain; Region: DUF304; pfam03703 167546003419 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167546003420 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 167546003421 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167546003422 Ycf46; Provisional; Region: ycf46; CHL00195 167546003423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546003424 Walker A motif; other site 167546003425 ATP binding site [chemical binding]; other site 167546003426 Walker B motif; other site 167546003427 arginine finger; other site 167546003428 seryl-tRNA synthetase; Provisional; Region: PRK05431 167546003429 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167546003430 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 167546003431 dimer interface [polypeptide binding]; other site 167546003432 active site 167546003433 motif 1; other site 167546003434 motif 2; other site 167546003435 motif 3; other site 167546003436 RIP metalloprotease RseP; Region: TIGR00054 167546003437 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167546003438 active site 167546003439 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 167546003440 protein binding site [polypeptide binding]; other site 167546003441 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167546003442 putative substrate binding region [chemical binding]; other site 167546003443 ribosomal protein S14; Region: rps14; CHL00074 167546003444 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167546003445 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 167546003446 RNase E interface [polypeptide binding]; other site 167546003447 trimer interface [polypeptide binding]; other site 167546003448 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167546003449 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 167546003450 RNase E interface [polypeptide binding]; other site 167546003451 trimer interface [polypeptide binding]; other site 167546003452 active site 167546003453 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167546003454 putative nucleic acid binding region [nucleotide binding]; other site 167546003455 G-X-X-G motif; other site 167546003456 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 167546003457 RNA binding site [nucleotide binding]; other site 167546003458 domain interface; other site 167546003459 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 167546003460 active site 167546003461 Predicted methyltransferases [General function prediction only]; Region: COG0313 167546003462 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 167546003463 putative SAM binding site [chemical binding]; other site 167546003464 putative homodimer interface [polypeptide binding]; other site 167546003465 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167546003466 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167546003467 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 167546003468 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167546003469 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167546003470 putative NAD(P) binding site [chemical binding]; other site 167546003471 active site 167546003472 putative substrate binding site [chemical binding]; other site 167546003473 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167546003474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167546003475 NAD binding site [chemical binding]; other site 167546003476 putative substrate binding site 2 [chemical binding]; other site 167546003477 putative substrate binding site 1 [chemical binding]; other site 167546003478 active site 167546003479 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 167546003480 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 167546003481 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 167546003482 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 167546003483 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 167546003484 Ligand binding site; other site 167546003485 oligomer interface; other site 167546003486 FOG: CBS domain [General function prediction only]; Region: COG0517 167546003487 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 167546003488 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 167546003489 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167546003490 Substrate binding site; other site 167546003491 metal-binding site 167546003492 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 167546003493 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 167546003494 active site 167546003495 homodimer interface [polypeptide binding]; other site 167546003496 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 167546003497 NeuB family; Region: NeuB; pfam03102 167546003498 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 167546003499 NeuB binding interface [polypeptide binding]; other site 167546003500 putative substrate binding site [chemical binding]; other site 167546003501 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 167546003502 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 167546003503 putative trimer interface [polypeptide binding]; other site 167546003504 putative CoA binding site [chemical binding]; other site 167546003505 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 167546003506 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167546003507 inhibitor-cofactor binding pocket; inhibition site 167546003508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546003509 catalytic residue [active] 167546003510 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 167546003511 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 167546003512 NAD binding site [chemical binding]; other site 167546003513 substrate binding site [chemical binding]; other site 167546003514 active site 167546003515 flagellin modification protein A; Provisional; Region: PRK09186 167546003516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546003517 NAD(P) binding site [chemical binding]; other site 167546003518 active site 167546003519 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 167546003520 ligand binding site; other site 167546003521 tetramer interface; other site 167546003522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167546003523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167546003524 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 167546003525 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167546003526 NAD binding site [chemical binding]; other site 167546003527 homodimer interface [polypeptide binding]; other site 167546003528 active site 167546003529 substrate binding site [chemical binding]; other site 167546003530 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167546003531 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167546003532 active site 167546003533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 167546003534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167546003535 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 167546003536 ligand binding site; other site 167546003537 tetramer interface; other site 167546003538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167546003539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546003540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167546003541 Walker A/P-loop; other site 167546003542 ATP binding site [chemical binding]; other site 167546003543 Q-loop/lid; other site 167546003544 ABC transporter signature motif; other site 167546003545 Walker B; other site 167546003546 D-loop; other site 167546003547 H-loop/switch region; other site 167546003548 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 167546003549 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167546003550 NAD binding site [chemical binding]; other site 167546003551 homodimer interface [polypeptide binding]; other site 167546003552 active site 167546003553 substrate binding site [chemical binding]; other site 167546003554 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 167546003555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167546003556 putative ADP-binding pocket [chemical binding]; other site 167546003557 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167546003558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546003559 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167546003560 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 167546003561 Mg++ binding site [ion binding]; other site 167546003562 putative catalytic motif [active] 167546003563 putative substrate binding site [chemical binding]; other site 167546003564 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167546003565 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 167546003566 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167546003567 NAD(P) binding site [chemical binding]; other site 167546003568 homodimer interface [polypeptide binding]; other site 167546003569 substrate binding site [chemical binding]; other site 167546003570 active site 167546003571 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 167546003572 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 167546003573 conserved cys residue [active] 167546003574 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 167546003575 phosphate binding site [ion binding]; other site 167546003576 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 167546003577 Ligand Binding Site [chemical binding]; other site 167546003578 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167546003579 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 167546003580 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167546003581 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167546003582 Substrate binding site; other site 167546003583 Cupin domain; Region: Cupin_2; cl17218 167546003584 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 167546003585 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 167546003586 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 167546003587 putative active site [active] 167546003588 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 167546003589 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 167546003590 classical (c) SDRs; Region: SDR_c; cd05233 167546003591 NAD(P) binding site [chemical binding]; other site 167546003592 active site 167546003593 Radical SAM superfamily; Region: Radical_SAM; pfam04055 167546003594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546003595 FeS/SAM binding site; other site 167546003596 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 167546003597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546003598 active site 167546003599 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167546003600 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 167546003601 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167546003602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546003603 S-adenosylmethionine binding site [chemical binding]; other site 167546003604 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167546003605 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167546003606 NADP-binding site; other site 167546003607 homotetramer interface [polypeptide binding]; other site 167546003608 substrate binding site [chemical binding]; other site 167546003609 homodimer interface [polypeptide binding]; other site 167546003610 active site 167546003611 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 167546003612 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 167546003613 NADP binding site [chemical binding]; other site 167546003614 active site 167546003615 putative substrate binding site [chemical binding]; other site 167546003616 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167546003617 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 167546003618 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 167546003619 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167546003620 Catalytic site [active] 167546003621 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167546003622 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167546003623 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167546003624 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 167546003625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546003626 Walker A motif; other site 167546003627 ATP binding site [chemical binding]; other site 167546003628 Walker B motif; other site 167546003629 arginine finger; other site 167546003630 Peptidase family M41; Region: Peptidase_M41; pfam01434 167546003631 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167546003632 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167546003633 catalytic motif [active] 167546003634 Zn binding site [ion binding]; other site 167546003635 RibD C-terminal domain; Region: RibD_C; cl17279 167546003636 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167546003637 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 167546003638 active site 167546003639 putative homodimer interface [polypeptide binding]; other site 167546003640 SAM binding site [chemical binding]; other site 167546003641 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 167546003642 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 167546003643 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 167546003644 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167546003645 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 167546003646 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 167546003647 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167546003648 dimer interface [polypeptide binding]; other site 167546003649 motif 1; other site 167546003650 active site 167546003651 motif 2; other site 167546003652 motif 3; other site 167546003653 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 167546003654 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167546003655 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167546003656 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167546003657 active site 167546003658 Riboflavin kinase; Region: Flavokinase; smart00904 167546003659 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167546003660 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167546003661 thiamine phosphate binding site [chemical binding]; other site 167546003662 active site 167546003663 pyrophosphate binding site [ion binding]; other site 167546003664 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167546003665 thiS-thiF/thiG interaction site; other site 167546003666 AIR carboxylase; Region: AIRC; smart01001 167546003667 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167546003668 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 167546003669 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167546003670 homotrimer interaction site [polypeptide binding]; other site 167546003671 zinc binding site [ion binding]; other site 167546003672 CDP-binding sites; other site 167546003673 GTPase Era; Reviewed; Region: era; PRK00089 167546003674 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 167546003675 G1 box; other site 167546003676 GTP/Mg2+ binding site [chemical binding]; other site 167546003677 Switch I region; other site 167546003678 G2 box; other site 167546003679 Switch II region; other site 167546003680 G3 box; other site 167546003681 G4 box; other site 167546003682 G5 box; other site 167546003683 KH domain; Region: KH_2; pfam07650 167546003684 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 167546003685 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 167546003686 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 167546003687 PhoH-like protein; Region: PhoH; pfam02562 167546003688 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 167546003689 signal recognition particle protein; Provisional; Region: PRK10867 167546003690 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 167546003691 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167546003692 P loop; other site 167546003693 GTP binding site [chemical binding]; other site 167546003694 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167546003695 DnaJ domain; Region: DnaJ; pfam00226 167546003696 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 167546003697 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 167546003698 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167546003699 tetramer interface [polypeptide binding]; other site 167546003700 TPP-binding site [chemical binding]; other site 167546003701 heterodimer interface [polypeptide binding]; other site 167546003702 phosphorylation loop region [posttranslational modification] 167546003703 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167546003704 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167546003705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167546003706 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167546003707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167546003708 DNA binding residues [nucleotide binding] 167546003709 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 167546003710 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167546003711 putative substrate binding site [chemical binding]; other site 167546003712 putative ATP binding site [chemical binding]; other site 167546003713 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 167546003714 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167546003715 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167546003716 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167546003717 putative active site [active] 167546003718 catalytic triad [active] 167546003719 putative dimer interface [polypeptide binding]; other site 167546003720 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 167546003721 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167546003722 superoxide dismutase, Ni; Region: sodN; TIGR02753 167546003723 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167546003724 Catalytic site [active] 167546003725 High-affinity nickel-transport protein; Region: NicO; cl00964 167546003726 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167546003727 active site 167546003728 ribulose/triose binding site [chemical binding]; other site 167546003729 phosphate binding site [ion binding]; other site 167546003730 substrate (anthranilate) binding pocket [chemical binding]; other site 167546003731 product (indole) binding pocket [chemical binding]; other site 167546003732 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167546003733 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 167546003734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167546003735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167546003736 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167546003737 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167546003738 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 167546003739 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167546003740 hinge; other site 167546003741 active site 167546003742 acetylornithine aminotransferase; Provisional; Region: PRK02627 167546003743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167546003744 inhibitor-cofactor binding pocket; inhibition site 167546003745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546003746 catalytic residue [active] 167546003747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167546003748 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167546003749 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167546003750 FAD binding domain; Region: FAD_binding_4; pfam01565 167546003751 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167546003752 putative deaminase; Validated; Region: PRK06846 167546003753 active site 167546003754 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167546003755 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167546003756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546003757 FeS/SAM binding site; other site 167546003758 TRAM domain; Region: TRAM; pfam01938 167546003759 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167546003760 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167546003761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167546003762 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 167546003763 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 167546003764 cell division protein FtsZ; Validated; Region: PRK09330 167546003765 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167546003766 nucleotide binding site [chemical binding]; other site 167546003767 SulA interaction site; other site 167546003768 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167546003769 oligomerization interface [polypeptide binding]; other site 167546003770 active site 167546003771 metal binding site [ion binding]; metal-binding site 167546003772 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167546003773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546003774 FeS/SAM binding site; other site 167546003775 HemN C-terminal domain; Region: HemN_C; pfam06969 167546003776 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 167546003777 putative active site [active] 167546003778 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 167546003779 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167546003780 oligomer interface [polypeptide binding]; other site 167546003781 active site residues [active] 167546003782 Clp protease; Region: CLP_protease; pfam00574 167546003783 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167546003784 oligomer interface [polypeptide binding]; other site 167546003785 active site residues [active] 167546003786 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167546003787 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 167546003788 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167546003789 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 167546003790 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167546003791 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 167546003792 IHF dimer interface [polypeptide binding]; other site 167546003793 IHF - DNA interface [nucleotide binding]; other site 167546003794 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 167546003795 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167546003796 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167546003797 active site 167546003798 catalytic site [active] 167546003799 MFS/sugar transport protein; Region: MFS_2; pfam13347 167546003800 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 167546003801 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 167546003802 Permease; Region: Permease; pfam02405 167546003803 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167546003804 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167546003805 membrane protein; Provisional; Region: PRK14419 167546003806 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 167546003807 active site 167546003808 dimer interface [polypeptide binding]; other site 167546003809 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 167546003810 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167546003811 active site 167546003812 HIGH motif; other site 167546003813 dimer interface [polypeptide binding]; other site 167546003814 KMSKS motif; other site 167546003815 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167546003816 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167546003817 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167546003818 interface (dimer of trimers) [polypeptide binding]; other site 167546003819 Substrate-binding/catalytic site; other site 167546003820 Zn-binding sites [ion binding]; other site 167546003821 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 167546003822 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167546003823 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 167546003824 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167546003825 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167546003826 active site 167546003827 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167546003828 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 167546003829 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167546003830 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167546003831 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 167546003832 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167546003833 Surface antigen; Region: Bac_surface_Ag; pfam01103 167546003834 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 167546003835 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167546003836 ATP binding site [chemical binding]; other site 167546003837 active site 167546003838 substrate binding site [chemical binding]; other site 167546003839 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167546003840 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167546003841 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 167546003842 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167546003843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167546003844 dimerization interface [polypeptide binding]; other site 167546003845 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 167546003846 PAS domain; Region: PAS; smart00091 167546003847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167546003848 dimer interface [polypeptide binding]; other site 167546003849 phosphorylation site [posttranslational modification] 167546003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546003851 ATP binding site [chemical binding]; other site 167546003852 Mg2+ binding site [ion binding]; other site 167546003853 G-X-G motif; other site 167546003854 circadian clock protein KaiC; Reviewed; Region: PRK09302 167546003855 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167546003856 Walker A motif; other site 167546003857 ATP binding site [chemical binding]; other site 167546003858 Walker B motif; other site 167546003859 recA bacterial DNA recombination protein; Region: RecA; cl17211 167546003860 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167546003861 Walker A motif; other site 167546003862 ATP binding site [chemical binding]; other site 167546003863 Walker B motif; other site 167546003864 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167546003865 tetramer interface [polypeptide binding]; other site 167546003866 dimer interface [polypeptide binding]; other site 167546003867 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 167546003868 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 167546003869 Methyltransferase domain; Region: Methyltransf_12; pfam08242 167546003870 S-adenosylmethionine binding site [chemical binding]; other site 167546003871 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167546003872 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 167546003873 RNA binding site [nucleotide binding]; other site 167546003874 active site 167546003875 Stage II sporulation protein; Region: SpoIID; pfam08486 167546003876 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167546003877 ribonuclease Z; Region: RNase_Z; TIGR02651 167546003878 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167546003879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167546003880 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167546003881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167546003882 catalytic loop [active] 167546003883 iron binding site [ion binding]; other site 167546003884 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167546003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546003886 S-adenosylmethionine binding site [chemical binding]; other site 167546003887 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167546003888 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 167546003889 ligand binding site [chemical binding]; other site 167546003890 NAD binding site [chemical binding]; other site 167546003891 dimerization interface [polypeptide binding]; other site 167546003892 catalytic site [active] 167546003893 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167546003894 putative L-serine binding site [chemical binding]; other site 167546003895 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167546003896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546003897 RNA binding surface [nucleotide binding]; other site 167546003898 Phospholipid methyltransferase; Region: PEMT; cl17370 167546003899 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 167546003900 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 167546003901 Predicted membrane protein [Function unknown]; Region: COG2259 167546003902 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167546003903 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167546003904 nucleotide binding pocket [chemical binding]; other site 167546003905 K-X-D-G motif; other site 167546003906 catalytic site [active] 167546003907 short chain dehydrogenase; Provisional; Region: PRK06197 167546003908 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167546003909 putative NAD(P) binding site [chemical binding]; other site 167546003910 active site 167546003911 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167546003912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167546003913 Pirin-related protein [General function prediction only]; Region: COG1741 167546003914 Pirin; Region: Pirin; pfam02678 167546003915 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 167546003916 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 167546003917 GAF domain; Region: GAF; pfam01590 167546003918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 167546003919 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 167546003920 flavoprotein, HI0933 family; Region: TIGR00275 167546003921 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 167546003922 Protein of unknown function (DUF805); Region: DUF805; pfam05656 167546003923 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167546003924 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167546003925 putative di-iron ligands [ion binding]; other site 167546003926 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167546003927 DNA-directed RNA polymerase subunit B; Provisional; Region: PRK08565 167546003928 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167546003929 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167546003930 putative di-iron ligands [ion binding]; other site 167546003931 Protein of unknown function (DUF938); Region: DUF938; pfam06080 167546003932 putative high light inducible protein; Region: PHA02337 167546003933 putative high light inducible protein; Region: PHA02337 167546003934 putative high light inducible protein; Region: PHA02337 167546003935 Predicted permeases [General function prediction only]; Region: COG0795 167546003936 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167546003937 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167546003938 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167546003939 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167546003940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167546003941 Cupin domain; Region: Cupin_2; pfam07883 167546003942 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167546003943 EVE domain; Region: EVE; cl00728 167546003944 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167546003945 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167546003946 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167546003947 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 167546003948 nucleotide binding site [chemical binding]; other site 167546003949 putative NEF/HSP70 interaction site [polypeptide binding]; other site 167546003950 SBD interface [polypeptide binding]; other site 167546003951 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 167546003952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167546003953 active site 167546003954 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 167546003955 phosphoglyceromutase; Provisional; Region: PRK05434 167546003956 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167546003957 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167546003958 ring oligomerisation interface [polypeptide binding]; other site 167546003959 ATP/Mg binding site [chemical binding]; other site 167546003960 stacking interactions; other site 167546003961 hinge regions; other site 167546003962 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167546003963 oligomerisation interface [polypeptide binding]; other site 167546003964 mobile loop; other site 167546003965 roof hairpin; other site 167546003966 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167546003967 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167546003968 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167546003969 alpha subunit interaction interface [polypeptide binding]; other site 167546003970 Walker A motif; other site 167546003971 ATP binding site [chemical binding]; other site 167546003972 Walker B motif; other site 167546003973 inhibitor binding site; inhibition site 167546003974 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167546003975 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167546003976 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 167546003977 gamma subunit interface [polypeptide binding]; other site 167546003978 epsilon subunit interface [polypeptide binding]; other site 167546003979 LBP interface [polypeptide binding]; other site 167546003980 hypothetical protein; Provisional; Region: PRK02724 167546003981 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 167546003982 proline aminopeptidase P II; Provisional; Region: PRK10879 167546003983 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167546003984 active site 167546003985 Domain of unknown function DUF21; Region: DUF21; pfam01595 167546003986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167546003987 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 167546003988 G1 box; other site 167546003989 GTP/Mg2+ binding site [chemical binding]; other site 167546003990 G2 box; other site 167546003991 Switch I region; other site 167546003992 G3 box; other site 167546003993 Switch II region; other site 167546003994 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167546003995 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 167546003996 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167546003997 active site 167546003998 (T/H)XGH motif; other site 167546003999 NAD synthetase; Provisional; Region: PRK13981 167546004000 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167546004001 multimer interface [polypeptide binding]; other site 167546004002 active site 167546004003 catalytic triad [active] 167546004004 protein interface 1 [polypeptide binding]; other site 167546004005 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167546004006 homodimer interface [polypeptide binding]; other site 167546004007 NAD binding pocket [chemical binding]; other site 167546004008 ATP binding pocket [chemical binding]; other site 167546004009 Mg binding site [ion binding]; other site 167546004010 active-site loop [active] 167546004011 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167546004012 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167546004013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167546004014 catalytic loop [active] 167546004015 iron binding site [ion binding]; other site 167546004016 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 167546004017 core domain interface [polypeptide binding]; other site 167546004018 delta subunit interface [polypeptide binding]; other site 167546004019 epsilon subunit interface [polypeptide binding]; other site 167546004020 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167546004021 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167546004022 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167546004023 beta subunit interaction interface [polypeptide binding]; other site 167546004024 Walker A motif; other site 167546004025 ATP binding site [chemical binding]; other site 167546004026 Walker B motif; other site 167546004027 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167546004028 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 167546004029 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 167546004030 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167546004031 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 167546004032 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167546004033 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 167546004034 ATP synthase CF0 C subunit; Region: atpH; CHL00061 167546004035 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 167546004036 ATP synthase CF0 A subunit; Region: atpI; CHL00046 167546004037 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 167546004038 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 167546004039 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 167546004040 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 167546004041 ResB-like family; Region: ResB; pfam05140 167546004042 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 167546004043 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 167546004044 Nitrogen regulatory protein P-II; Region: P-II; smart00938 167546004045 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167546004046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167546004047 RNA binding surface [nucleotide binding]; other site 167546004048 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 167546004049 adenylosuccinate lyase; Provisional; Region: PRK07380 167546004050 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167546004051 tetramer interface [polypeptide binding]; other site 167546004052 active site 167546004053 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 167546004054 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167546004055 Class II fumarases; Region: Fumarase_classII; cd01362 167546004056 active site 167546004057 tetramer interface [polypeptide binding]; other site 167546004058 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167546004059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546004060 ATP binding site [chemical binding]; other site 167546004061 putative Mg++ binding site [ion binding]; other site 167546004062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546004063 nucleotide binding region [chemical binding]; other site 167546004064 ATP-binding site [chemical binding]; other site 167546004065 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167546004066 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 167546004067 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 167546004068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546004069 catalytic residue [active] 167546004070 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167546004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546004072 S-adenosylmethionine binding site [chemical binding]; other site 167546004073 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 167546004074 AAA domain; Region: AAA_26; pfam13500 167546004075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167546004076 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 167546004077 inhibitor-cofactor binding pocket; inhibition site 167546004078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546004079 catalytic residue [active] 167546004080 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 167546004081 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167546004082 HSP70 interaction site [polypeptide binding]; other site 167546004083 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 167546004084 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 167546004085 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167546004086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167546004087 active site 167546004088 catalytic tetrad [active] 167546004089 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 167546004090 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 167546004091 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167546004092 HEAT repeats; Region: HEAT_2; pfam13646 167546004093 HEAT repeats; Region: HEAT_2; pfam13646 167546004094 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167546004095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546004096 FeS/SAM binding site; other site 167546004097 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167546004098 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167546004099 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 167546004100 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167546004101 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167546004102 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167546004103 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167546004104 DNA binding site [nucleotide binding] 167546004105 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167546004106 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167546004107 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 167546004108 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 167546004109 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167546004110 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167546004111 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 167546004112 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167546004113 RPB1 interaction site [polypeptide binding]; other site 167546004114 RPB10 interaction site [polypeptide binding]; other site 167546004115 RPB11 interaction site [polypeptide binding]; other site 167546004116 RPB3 interaction site [polypeptide binding]; other site 167546004117 RPB12 interaction site [polypeptide binding]; other site 167546004118 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167546004119 active site 167546004120 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 167546004121 histidinol dehydrogenase; Region: hisD; TIGR00069 167546004122 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167546004123 NAD binding site [chemical binding]; other site 167546004124 dimerization interface [polypeptide binding]; other site 167546004125 product binding site; other site 167546004126 substrate binding site [chemical binding]; other site 167546004127 zinc binding site [ion binding]; other site 167546004128 catalytic residues [active] 167546004129 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167546004130 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167546004131 active site 167546004132 dimer interface [polypeptide binding]; other site 167546004133 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167546004134 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167546004135 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167546004136 protein binding site [polypeptide binding]; other site 167546004137 hypothetical protein; Provisional; Region: PRK14646 167546004138 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 167546004139 heptamer interface [polypeptide binding]; other site 167546004140 Sm1 motif; other site 167546004141 hexamer interface [polypeptide binding]; other site 167546004142 RNA binding site [nucleotide binding]; other site 167546004143 Sm2 motif; other site 167546004144 NusA N-terminal domain; Region: NusA_N; pfam08529 167546004145 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 167546004146 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 167546004147 RNA binding site [nucleotide binding]; other site 167546004148 homodimer interface [polypeptide binding]; other site 167546004149 NusA-like KH domain; Region: KH_5; pfam13184 167546004150 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167546004151 G-X-X-G motif; other site 167546004152 Protein of unknown function (DUF448); Region: DUF448; pfam04296 167546004153 translation initiation factor IF-2; Region: IF-2; TIGR00487 167546004154 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167546004155 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 167546004156 G1 box; other site 167546004157 putative GEF interaction site [polypeptide binding]; other site 167546004158 GTP/Mg2+ binding site [chemical binding]; other site 167546004159 Switch I region; other site 167546004160 G2 box; other site 167546004161 G3 box; other site 167546004162 Switch II region; other site 167546004163 G4 box; other site 167546004164 G5 box; other site 167546004165 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167546004166 Translation-initiation factor 2; Region: IF-2; pfam11987 167546004167 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167546004168 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167546004169 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167546004170 Ligand binding site; other site 167546004171 Putative Catalytic site; other site 167546004172 DXD motif; other site 167546004173 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 167546004174 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167546004175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 167546004176 FeS/SAM binding site; other site 167546004177 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 167546004178 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 167546004179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167546004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546004181 homodimer interface [polypeptide binding]; other site 167546004182 catalytic residue [active] 167546004183 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167546004184 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167546004185 homodimer interface [polypeptide binding]; other site 167546004186 oligonucleotide binding site [chemical binding]; other site 167546004187 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167546004188 RNA/DNA hybrid binding site [nucleotide binding]; other site 167546004189 active site 167546004190 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167546004191 prephenate dehydratase; Provisional; Region: PRK11898 167546004192 Prephenate dehydratase; Region: PDT; pfam00800 167546004193 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167546004194 putative L-Phe binding site [chemical binding]; other site 167546004195 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167546004196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546004197 S-adenosylmethionine binding site [chemical binding]; other site 167546004198 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167546004199 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 167546004200 elongation factor Tu; Reviewed; Region: PRK00049 167546004201 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 167546004202 G1 box; other site 167546004203 GEF interaction site [polypeptide binding]; other site 167546004204 GTP/Mg2+ binding site [chemical binding]; other site 167546004205 Switch I region; other site 167546004206 G2 box; other site 167546004207 G3 box; other site 167546004208 Switch II region; other site 167546004209 G4 box; other site 167546004210 G5 box; other site 167546004211 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167546004212 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167546004213 Antibiotic Binding Site [chemical binding]; other site 167546004214 elongation factor G; Reviewed; Region: PRK00007 167546004215 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 167546004216 G1 box; other site 167546004217 putative GEF interaction site [polypeptide binding]; other site 167546004218 GTP/Mg2+ binding site [chemical binding]; other site 167546004219 Switch I region; other site 167546004220 G2 box; other site 167546004221 G3 box; other site 167546004222 Switch II region; other site 167546004223 G4 box; other site 167546004224 G5 box; other site 167546004225 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167546004226 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167546004227 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167546004228 30S ribosomal protein S7; Validated; Region: PRK05302 167546004229 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167546004230 S17 interaction site [polypeptide binding]; other site 167546004231 S8 interaction site; other site 167546004232 16S rRNA interaction site [nucleotide binding]; other site 167546004233 streptomycin interaction site [chemical binding]; other site 167546004234 23S rRNA interaction site [nucleotide binding]; other site 167546004235 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167546004236 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167546004237 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167546004238 active site 167546004239 dimer interface [polypeptide binding]; other site 167546004240 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167546004241 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167546004242 active site 167546004243 FMN binding site [chemical binding]; other site 167546004244 substrate binding site [chemical binding]; other site 167546004245 3Fe-4S cluster binding site [ion binding]; other site 167546004246 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167546004247 domain interface; other site 167546004248 YCII-related domain; Region: YCII; cl00999 167546004249 lipoyl synthase; Provisional; Region: PRK05481 167546004250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167546004251 FeS/SAM binding site; other site 167546004252 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 167546004253 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 167546004254 catalytic residues [active] 167546004255 catalytic nucleophile [active] 167546004256 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 167546004257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 167546004258 NlpC/P60 family; Region: NLPC_P60; pfam00877 167546004259 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 167546004260 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 167546004261 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167546004262 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167546004263 Ligand binding site; other site 167546004264 Putative Catalytic site; other site 167546004265 DXD motif; other site 167546004266 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 167546004267 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 167546004268 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 167546004269 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167546004270 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167546004271 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 167546004272 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 167546004273 active site 167546004274 SAM binding site [chemical binding]; other site 167546004275 homodimer interface [polypeptide binding]; other site 167546004276 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167546004277 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 167546004278 alanine racemase; Reviewed; Region: alr; PRK00053 167546004279 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167546004280 active site 167546004281 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167546004282 dimer interface [polypeptide binding]; other site 167546004283 substrate binding site [chemical binding]; other site 167546004284 catalytic residues [active] 167546004285 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 167546004286 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167546004287 active site 167546004288 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167546004289 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167546004290 RF-1 domain; Region: RF-1; pfam00472 167546004291 ribosomal protein L31; Validated; Region: rpl31; CHL00136 167546004292 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 167546004293 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167546004294 23S rRNA interface [nucleotide binding]; other site 167546004295 L3 interface [polypeptide binding]; other site 167546004296 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167546004297 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 167546004298 dimerization interface 3.5A [polypeptide binding]; other site 167546004299 active site 167546004300 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 167546004301 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167546004302 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167546004303 alphaNTD homodimer interface [polypeptide binding]; other site 167546004304 alphaNTD - beta interaction site [polypeptide binding]; other site 167546004305 alphaNTD - beta' interaction site [polypeptide binding]; other site 167546004306 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 167546004307 30S ribosomal protein S11; Validated; Region: PRK05309 167546004308 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 167546004309 30S ribosomal protein S13; Region: bact_S13; TIGR03631 167546004310 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167546004311 adenylate kinase; Reviewed; Region: adk; PRK00279 167546004312 AMP-binding site [chemical binding]; other site 167546004313 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167546004314 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167546004315 SecY translocase; Region: SecY; pfam00344 167546004316 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 167546004317 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167546004318 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167546004319 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167546004320 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167546004321 5S rRNA interface [nucleotide binding]; other site 167546004322 L27 interface [polypeptide binding]; other site 167546004323 23S rRNA interface [nucleotide binding]; other site 167546004324 L5 interface [polypeptide binding]; other site 167546004325 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167546004326 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167546004327 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167546004328 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 167546004329 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167546004330 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167546004331 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167546004332 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 167546004333 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 167546004334 RNA binding site [nucleotide binding]; other site 167546004335 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 167546004336 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 167546004337 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167546004338 23S rRNA interface [nucleotide binding]; other site 167546004339 putative translocon interaction site; other site 167546004340 signal recognition particle (SRP54) interaction site; other site 167546004341 L23 interface [polypeptide binding]; other site 167546004342 trigger factor interaction site; other site 167546004343 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167546004344 23S rRNA interface [nucleotide binding]; other site 167546004345 5S rRNA interface [nucleotide binding]; other site 167546004346 putative antibiotic binding site [chemical binding]; other site 167546004347 L25 interface [polypeptide binding]; other site 167546004348 L27 interface [polypeptide binding]; other site 167546004349 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167546004350 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167546004351 G-X-X-G motif; other site 167546004352 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167546004353 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167546004354 putative translocon binding site; other site 167546004355 protein-rRNA interface [nucleotide binding]; other site 167546004356 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 167546004357 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167546004358 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167546004359 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167546004360 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 167546004361 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 167546004362 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 167546004363 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167546004364 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167546004365 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167546004366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 167546004367 motif II; other site 167546004368 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167546004369 recombinase A; Provisional; Region: recA; PRK09354 167546004370 hexamer interface [polypeptide binding]; other site 167546004371 Walker A motif; other site 167546004372 ATP binding site [chemical binding]; other site 167546004373 Walker B motif; other site 167546004374 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167546004375 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 167546004376 arogenate dehydrogenase; Reviewed; Region: PRK07417 167546004377 prephenate dehydrogenase; Validated; Region: PRK08507 167546004378 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 167546004379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167546004380 Fructosamine kinase; Region: Fructosamin_kin; cl17579 167546004381 Phosphotransferase enzyme family; Region: APH; pfam01636 167546004382 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 167546004383 hypothetical protein; Validated; Region: PRK07411 167546004384 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167546004385 ATP binding site [chemical binding]; other site 167546004386 substrate interface [chemical binding]; other site 167546004387 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167546004388 active site residue [active] 167546004389 hypothetical protein; Validated; Region: PRK07413 167546004390 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 167546004391 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167546004392 Walker A motif; other site 167546004393 homodimer interface [polypeptide binding]; other site 167546004394 ATP binding site [chemical binding]; other site 167546004395 hydroxycobalamin binding site [chemical binding]; other site 167546004396 Walker B motif; other site 167546004397 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167546004398 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167546004399 Ligand Binding Site [chemical binding]; other site 167546004400 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 167546004401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546004402 Q-loop/lid; other site 167546004403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546004404 ABC transporter signature motif; other site 167546004405 Walker B; other site 167546004406 D-loop; other site 167546004407 H-loop/switch region; other site 167546004408 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 167546004409 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 167546004410 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167546004411 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167546004412 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167546004413 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167546004414 PsaD; Region: PsaD; pfam02531 167546004415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167546004416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167546004417 dimer interface [polypeptide binding]; other site 167546004418 phosphorylation site [posttranslational modification] 167546004419 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 167546004420 Domain of unknown function DUF59; Region: DUF59; pfam01883 167546004421 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 167546004422 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167546004423 Walker A motif; other site 167546004424 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 167546004425 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 167546004426 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167546004427 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167546004428 catalytic site [active] 167546004429 putative active site [active] 167546004430 putative substrate binding site [chemical binding]; other site 167546004431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167546004432 conserved hypothetical protein; Region: TIGR03492 167546004433 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 167546004434 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167546004435 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167546004436 dimerization interface [polypeptide binding]; other site 167546004437 putative ATP binding site [chemical binding]; other site 167546004438 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167546004439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167546004440 active site 167546004441 nucleotide binding site [chemical binding]; other site 167546004442 HIGH motif; other site 167546004443 KMSKS motif; other site 167546004444 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167546004445 active site 167546004446 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167546004447 CMP-binding site; other site 167546004448 The sites determining sugar specificity; other site 167546004449 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 167546004450 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167546004451 active site 167546004452 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 167546004453 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 167546004454 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167546004455 heme binding pocket [chemical binding]; other site 167546004456 heme ligand [chemical binding]; other site 167546004457 isocitrate dehydrogenase; Validated; Region: PRK07362 167546004458 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167546004459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 167546004460 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167546004461 active site 167546004462 catalytic residues [active] 167546004463 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167546004464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167546004465 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 167546004466 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 167546004467 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167546004468 homodimer interface [polypeptide binding]; other site 167546004469 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167546004470 active site pocket [active] 167546004471 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 167546004472 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167546004473 dimerization interface [polypeptide binding]; other site 167546004474 active site 167546004475 metal binding site [ion binding]; metal-binding site 167546004476 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167546004477 dsRNA binding site [nucleotide binding]; other site 167546004478 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167546004479 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167546004480 RimM N-terminal domain; Region: RimM; pfam01782 167546004481 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167546004482 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167546004483 glutaminase active site [active] 167546004484 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167546004485 dimer interface [polypeptide binding]; other site 167546004486 active site 167546004487 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167546004488 dimer interface [polypeptide binding]; other site 167546004489 active site 167546004490 photosystem I subunit VII; Region: psaC; CHL00065 167546004491 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167546004492 acyl carrier protein; Provisional; Region: acpP; PRK00982 167546004493 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167546004494 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167546004495 dimer interface [polypeptide binding]; other site 167546004496 active site 167546004497 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167546004498 transketolase; Region: PLN02790 167546004499 TPP-binding site [chemical binding]; other site 167546004500 dimer interface [polypeptide binding]; other site 167546004501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167546004502 PYR/PP interface [polypeptide binding]; other site 167546004503 dimer interface [polypeptide binding]; other site 167546004504 TPP binding site [chemical binding]; other site 167546004505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167546004506 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 167546004507 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 167546004508 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 167546004509 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167546004510 metal binding site [ion binding]; metal-binding site 167546004511 dimer interface [polypeptide binding]; other site 167546004512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546004513 binding surface 167546004514 TPR motif; other site 167546004515 TPR repeat; Region: TPR_11; pfam13414 167546004516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546004517 binding surface 167546004518 TPR motif; other site 167546004519 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167546004520 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167546004521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546004522 Walker A motif; other site 167546004523 ATP binding site [chemical binding]; other site 167546004524 Walker B motif; other site 167546004525 arginine finger; other site 167546004526 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167546004527 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167546004528 SmpB-tmRNA interface; other site 167546004529 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167546004530 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167546004531 dimer interface [polypeptide binding]; other site 167546004532 putative anticodon binding site; other site 167546004533 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167546004534 motif 1; other site 167546004535 active site 167546004536 motif 2; other site 167546004537 motif 3; other site 167546004538 Ycf27; Reviewed; Region: orf27; CHL00148 167546004539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167546004540 active site 167546004541 phosphorylation site [posttranslational modification] 167546004542 intermolecular recognition site; other site 167546004543 dimerization interface [polypeptide binding]; other site 167546004544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167546004545 DNA binding site [nucleotide binding] 167546004546 rod shape-determining protein MreC; Provisional; Region: PRK13922 167546004547 rod shape-determining protein MreC; Region: MreC; pfam04085 167546004548 rod shape-determining protein MreB; Provisional; Region: PRK13927 167546004549 MreB and similar proteins; Region: MreB_like; cd10225 167546004550 nucleotide binding site [chemical binding]; other site 167546004551 Mg binding site [ion binding]; other site 167546004552 putative protofilament interaction site [polypeptide binding]; other site 167546004553 RodZ interaction site [polypeptide binding]; other site 167546004554 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167546004555 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167546004556 dimer interface [polypeptide binding]; other site 167546004557 ssDNA binding site [nucleotide binding]; other site 167546004558 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167546004559 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 167546004560 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167546004561 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167546004562 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 167546004563 homotetramer interface [polypeptide binding]; other site 167546004564 ligand binding site [chemical binding]; other site 167546004565 catalytic site [active] 167546004566 NAD binding site [chemical binding]; other site 167546004567 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 167546004568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167546004569 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167546004570 putative substrate binding site [chemical binding]; other site 167546004571 putative ATP binding site [chemical binding]; other site 167546004572 hydrolase, alpha/beta fold family protein; Region: PLN02824 167546004573 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167546004574 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167546004575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167546004576 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167546004577 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 167546004578 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167546004579 MgtE intracellular N domain; Region: MgtE_N; smart00924 167546004580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167546004581 Divalent cation transporter; Region: MgtE; pfam01769 167546004582 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167546004583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167546004584 ATP binding site [chemical binding]; other site 167546004585 Mg2+ binding site [ion binding]; other site 167546004586 G-X-G motif; other site 167546004587 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167546004588 anchoring element; other site 167546004589 dimer interface [polypeptide binding]; other site 167546004590 ATP binding site [chemical binding]; other site 167546004591 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167546004592 active site 167546004593 putative metal-binding site [ion binding]; other site 167546004594 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167546004595 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 167546004596 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 167546004597 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167546004598 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167546004599 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167546004600 Predicted transcriptional regulators [Transcription]; Region: COG1725 167546004601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167546004602 DNA-binding site [nucleotide binding]; DNA binding site 167546004603 serine O-acetyltransferase; Region: cysE; TIGR01172 167546004604 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 167546004605 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167546004606 trimer interface [polypeptide binding]; other site 167546004607 active site 167546004608 substrate binding site [chemical binding]; other site 167546004609 CoA binding site [chemical binding]; other site 167546004610 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167546004611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546004612 ATP binding site [chemical binding]; other site 167546004613 putative Mg++ binding site [ion binding]; other site 167546004614 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 167546004615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167546004616 Coenzyme A binding pocket [chemical binding]; other site 167546004617 SnoaL-like domain; Region: SnoaL_2; pfam12680 167546004618 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167546004619 homopentamer interface [polypeptide binding]; other site 167546004620 active site 167546004621 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 167546004622 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167546004623 MutS domain I; Region: MutS_I; pfam01624 167546004624 MutS domain II; Region: MutS_II; pfam05188 167546004625 MutS domain III; Region: MutS_III; pfam05192 167546004626 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 167546004627 Walker A/P-loop; other site 167546004628 ATP binding site [chemical binding]; other site 167546004629 Q-loop/lid; other site 167546004630 ABC transporter signature motif; other site 167546004631 Walker B; other site 167546004632 D-loop; other site 167546004633 H-loop/switch region; other site 167546004634 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 167546004635 Precorrin-8X methylmutase; Region: CbiC; pfam02570 167546004636 DNA polymerase III subunit delta; Validated; Region: PRK07452 167546004637 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 167546004638 aspartate kinase; Provisional; Region: PRK07431 167546004639 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167546004640 putative nucleotide binding site [chemical binding]; other site 167546004641 putative catalytic residues [active] 167546004642 putative Mg ion binding site [ion binding]; other site 167546004643 putative aspartate binding site [chemical binding]; other site 167546004644 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167546004645 putative allosteric regulatory site; other site 167546004646 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167546004647 putative allosteric regulatory residue; other site 167546004648 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167546004649 putative allosteric regulatory site; other site 167546004650 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167546004651 putative allosteric regulatory residue; other site 167546004652 excinuclease ABC subunit B; Provisional; Region: PRK05298 167546004653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167546004654 ATP binding site [chemical binding]; other site 167546004655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167546004656 nucleotide binding region [chemical binding]; other site 167546004657 ATP-binding site [chemical binding]; other site 167546004658 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167546004659 UvrB/uvrC motif; Region: UVR; pfam02151 167546004660 Protein of unknown function (DUF561); Region: DUF561; pfam04481 167546004661 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 167546004662 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167546004663 Ligand Binding Site [chemical binding]; other site 167546004664 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167546004665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 167546004666 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 167546004667 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167546004668 dihydrodipicolinate synthase; Region: dapA; TIGR00674 167546004669 dimer interface [polypeptide binding]; other site 167546004670 active site 167546004671 catalytic residue [active] 167546004672 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167546004673 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167546004674 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 167546004675 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 167546004676 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167546004677 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167546004678 Clp protease; Region: CLP_protease; pfam00574 167546004679 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167546004680 oligomer interface [polypeptide binding]; other site 167546004681 active site residues [active] 167546004682 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167546004683 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 167546004684 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 167546004685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546004686 Walker A motif; other site 167546004687 ATP binding site [chemical binding]; other site 167546004688 Walker B motif; other site 167546004689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167546004690 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167546004691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167546004692 Walker A motif; other site 167546004693 ATP binding site [chemical binding]; other site 167546004694 Walker B motif; other site 167546004695 arginine finger; other site 167546004696 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167546004697 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 167546004698 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167546004699 DXD motif; other site 167546004700 Sporulation related domain; Region: SPOR; cl10051 167546004701 Stage II sporulation protein; Region: SpoIID; pfam08486 167546004702 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167546004703 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 167546004704 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167546004705 23S rRNA binding site [nucleotide binding]; other site 167546004706 L21 binding site [polypeptide binding]; other site 167546004707 L13 binding site [polypeptide binding]; other site 167546004708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167546004709 binding surface 167546004710 TPR motif; other site 167546004711 TPR repeat; Region: TPR_11; pfam13414 167546004712 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167546004713 ThiS interaction site; other site 167546004714 putative active site [active] 167546004715 tetramer interface [polypeptide binding]; other site 167546004716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167546004717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167546004718 NAD(P) binding site [chemical binding]; other site 167546004719 active site 167546004720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167546004721 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167546004722 glycine dehydrogenase; Provisional; Region: PRK05367 167546004723 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167546004724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167546004725 catalytic residue [active] 167546004726 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167546004727 tetramer interface [polypeptide binding]; other site 167546004728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546004729 catalytic residue [active] 167546004730 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167546004731 lipoyl attachment site [posttranslational modification]; other site 167546004732 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 167546004733 Aluminium resistance protein; Region: Alum_res; pfam06838 167546004734 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167546004735 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167546004736 Di-iron ligands [ion binding]; other site 167546004737 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167546004738 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167546004739 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167546004740 replicative DNA helicase; Region: DnaB; TIGR00665 167546004741 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167546004742 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167546004743 Walker A motif; other site 167546004744 ATP binding site [chemical binding]; other site 167546004745 Walker B motif; other site 167546004746 DNA binding loops [nucleotide binding] 167546004747 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167546004748 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167546004749 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167546004750 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 167546004751 Protein of unknown function (DUF98); Region: DUF98; pfam01947 167546004752 SprT-like family; Region: SprT-like; pfam10263 167546004753 SprT homologues; Region: SprT; cl01182 167546004754 DNA ligase; Provisional; Region: 30; PHA02587 167546004755 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 167546004756 active site 167546004757 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 167546004758 DNA binding site [nucleotide binding] 167546004759 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167546004760 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167546004761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167546004762 active site 167546004763 HIGH motif; other site 167546004764 nucleotide binding site [chemical binding]; other site 167546004765 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167546004766 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167546004767 active site 167546004768 KMSKS motif; other site 167546004769 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167546004770 tRNA binding surface [nucleotide binding]; other site 167546004771 anticodon binding site; other site 167546004772 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167546004773 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 167546004774 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 167546004775 homodimer interface [polypeptide binding]; other site 167546004776 metal binding site [ion binding]; metal-binding site 167546004777 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 167546004778 homodimer interface [polypeptide binding]; other site 167546004779 active site 167546004780 putative chemical substrate binding site [chemical binding]; other site 167546004781 metal binding site [ion binding]; metal-binding site 167546004782 spermidine synthase; Provisional; Region: PRK00811 167546004783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167546004784 S-adenosylmethionine binding site [chemical binding]; other site 167546004785 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 167546004786 agmatinase; Region: agmatinase; TIGR01230 167546004787 putative active site [active] 167546004788 Mn binding site [ion binding]; other site 167546004789 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167546004790 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167546004791 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167546004792 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167546004793 dimer interface [polypeptide binding]; other site 167546004794 anticodon binding site; other site 167546004795 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167546004796 motif 1; other site 167546004797 dimer interface [polypeptide binding]; other site 167546004798 active site 167546004799 motif 2; other site 167546004800 GAD domain; Region: GAD; pfam02938 167546004801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167546004802 active site 167546004803 motif 3; other site 167546004804 CTP synthetase; Validated; Region: pyrG; PRK05380 167546004805 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167546004806 Catalytic site [active] 167546004807 active site 167546004808 UTP binding site [chemical binding]; other site 167546004809 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167546004810 active site 167546004811 putative oxyanion hole; other site 167546004812 catalytic triad [active] 167546004813 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167546004814 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 167546004815 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167546004816 Ligand Binding Site [chemical binding]; other site 167546004817 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167546004818 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167546004819 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167546004820 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167546004821 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 167546004822 homodimer interface [polypeptide binding]; other site 167546004823 substrate-cofactor binding pocket; other site 167546004824 Aminotransferase class IV; Region: Aminotran_4; pfam01063 167546004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546004826 catalytic residue [active] 167546004827 diphthine synthase; Region: dph5; TIGR00522 167546004828 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 167546004829 active site 167546004830 SAM binding site [chemical binding]; other site 167546004831 homodimer interface [polypeptide binding]; other site 167546004832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167546004833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167546004834 putative substrate translocation pore; other site 167546004835 polyphosphate kinase; Provisional; Region: PRK05443 167546004836 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 167546004837 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 167546004838 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 167546004839 putative domain interface [polypeptide binding]; other site 167546004840 putative active site [active] 167546004841 catalytic site [active] 167546004842 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167546004843 putative domain interface [polypeptide binding]; other site 167546004844 putative active site [active] 167546004845 catalytic site [active] 167546004846 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167546004847 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167546004848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167546004849 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167546004850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167546004851 DNA binding residues [nucleotide binding] 167546004852 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 167546004853 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 167546004854 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 167546004855 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167546004856 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167546004857 substrate binding site [chemical binding]; other site 167546004858 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167546004859 substrate binding site [chemical binding]; other site 167546004860 ligand binding site [chemical binding]; other site 167546004861 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167546004862 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 167546004863 Cl- selectivity filter; other site 167546004864 Cl- binding residues [ion binding]; other site 167546004865 pore gating glutamate residue; other site 167546004866 dimer interface [polypeptide binding]; other site 167546004867 H+/Cl- coupling transport residue; other site 167546004868 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 167546004869 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 167546004870 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 167546004871 putative active site [active] 167546004872 putative substrate binding site [chemical binding]; other site 167546004873 putative cosubstrate binding site; other site 167546004874 catalytic site [active] 167546004875 FAD dependent oxidoreductase; Region: DAO; pfam01266 167546004876 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 167546004877 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167546004878 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 167546004879 nucleotide binding site [chemical binding]; other site 167546004880 NEF interaction site [polypeptide binding]; other site 167546004881 SBD interface [polypeptide binding]; other site 167546004882 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167546004883 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167546004884 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167546004885 shikimate binding site; other site 167546004886 NAD(P) binding site [chemical binding]; other site 167546004887 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 167546004888 argininosuccinate synthase; Provisional; Region: PRK13820 167546004889 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167546004890 ANP binding site [chemical binding]; other site 167546004891 Substrate Binding Site II [chemical binding]; other site 167546004892 Substrate Binding Site I [chemical binding]; other site 167546004893 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167546004894 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 167546004895 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167546004896 Mg++ binding site [ion binding]; other site 167546004897 putative catalytic motif [active] 167546004898 putative substrate binding site [chemical binding]; other site 167546004899 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167546004900 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167546004901 putative ADP-binding pocket [chemical binding]; other site 167546004902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167546004903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167546004904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167546004905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 167546004906 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167546004907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167546004908 Walker A/P-loop; other site 167546004909 ATP binding site [chemical binding]; other site 167546004910 Q-loop/lid; other site 167546004911 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 167546004912 Q-loop/lid; other site 167546004913 ABC transporter signature motif; other site 167546004914 Walker B; other site 167546004915 D-loop; other site 167546004916 H-loop/switch region; other site 167546004917 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167546004918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 167546004919 active site 167546004920 substrate binding site [chemical binding]; other site 167546004921 ATP binding site [chemical binding]; other site 167546004922 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167546004923 threonine synthase; Validated; Region: PRK06260 167546004924 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167546004925 homodimer interface [polypeptide binding]; other site 167546004926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167546004927 catalytic residue [active]