-- dump date   	20140620_000215
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_001016022.1	binds the polymerase to DNA and acts as a sliding clamp
YP_001016024.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001016025.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_001016026.1	COG188 type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), subunit alpha [DNA replication, recombination, and repair]
YP_001016028.1	COG1600 Uncharacterized Fe-S protein [Energy production and conversion]
YP_001016030.1	COG2928 Uncharacterized conserved protein [Function unknown]
YP_001016031.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_001016032.1	COG552 Signal recognition particle GTPase [Intracellular trafficking and secretion]
YP_001016033.1	COG2208 serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / transcription]
YP_001016034.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_001016036.1	COG42 tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]
YP_001016037.1	COG229 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001016038.1	COG2081 Predicted flavoproteins [general function prediction only]
YP_001016039.1	COG1459 type II secretory pathway, component PulF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016040.1	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016041.1	COG2804 type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016042.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_001016043.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_001016045.1	COG1162 Predicted GTPases [general function prediction only]
YP_001016046.1	COG718 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016047.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_001016048.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_001016049.1	COG57 glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [carbohydrate transport and metabolism]
YP_001016050.1	COG611 thiamine monophosphate kinase [Coenzyme metabolism]
YP_001016051.1	COG652 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001016052.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_001016053.1	COG511 Biotin carboxyl carrier protein [lipid metabolism]
YP_001016054.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_001016056.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016059.1	COG553 Superfamily II DNA/RNA helicases, SNF2 family [transcription / DNA replication, recombination, and repair]
YP_001016065.1	COG75 serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]
YP_001016066.1	Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A
YP_001016067.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_001016071.1	COG768 cell division protein FtsI/penicillin-binding protein 2 [cell envelope biogenesis, outer membrane]
YP_001016072.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001016073.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016075.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_001016081.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_001016082.1	COG291 ribosomal protein L35 [translation, ribosomal structure and biogenesis]
YP_001016084.1	COG2385 sporulation protein and related proteins [cell division and chromosome partitioning]
YP_001016085.1	COG1215 glycosyltransferases, probably involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001016086.1	COG2812 DNA polymerase III gamma/tau subunits [DNA replication, recombination, and repair]
YP_001016088.1	COG1404 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]
YP_001016090.1	binds and unfolds substrates as part of the ClpXP protease
YP_001016091.1	COG740 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001016092.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_001016093.1	COG136 aspartate-semialdehyde dehydrogenase [Amino acid transport and metabolism]
YP_001016094.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_001016096.1	COG595 Predicted hydrolase of the metallo-beta-lactamase superfamily [general function prediction only]
YP_001016098.1	COG37 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control [cell division and chromosome partitioning]
YP_001016101.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_001016104.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP
YP_001016105.1	required for the assembly and function of the DNAX complex which are required for the assembly of the subunit beta onto primed DNA
YP_001016106.1	COG2082 precorrin isomerase [Coenzyme metabolism]
YP_001016107.1	COG1566 Multidrug resistance efflux pump [Defense mechanisms]
YP_001016108.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001016110.1	This protein performs the mismatch recognition step during the DNA repair process
YP_001016112.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; subunit beta of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_001016114.1	COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [cell envelope biogenesis, outer membrane]
YP_001016116.1	COG1091 dTDP-4-dehydrorhamnose reductase [cell envelope biogenesis, outer membrane]
YP_001016117.1	COG241 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]
YP_001016118.1	COG1208 nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/subunit epsilons (eIF-2Bgamma/eIF-2Bepsilon) [cell envelope biogenesis, outer membrane / translation, ribosomal structure an
YP_001016119.1	COG279 phosphoheptose isomerase [carbohydrate transport and metabolism]
YP_001016120.1	COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [cell envelope biogenesis, outer membrane]
YP_001016121.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016122.1	COG535 Predicted Fe-S oxidoreductases [general function prediction only]
YP_001016123.1	COG1071 pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, subunit alpha [Energy production and conversion]
YP_001016124.1	COG22 pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type subunit beta [Energy production and conversion]
YP_001016126.1	COG535 Predicted Fe-S oxidoreductases [general function prediction only]
YP_001016127.1	COG107 imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]
YP_001016129.1	COG381 UDP-N-acetylglucosamine 2-epimerase [cell envelope biogenesis, outer membrane]
YP_001016130.1	COG2089 Sialic acid synthase [cell envelope biogenesis, outer membrane]
YP_001016131.1	COG663 carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [general function prediction only]
YP_001016132.1	COG399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001016133.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016134.1	COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001016135.1	COG1083 CMP-N-acetylneuraminic acid synthetase [cell envelope biogenesis, outer membrane]
YP_001016136.1	COG673 Predicted dehydrogenases and related proteins [general function prediction only]
YP_001016137.1	COG1208 nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/subunit epsilons (eIF-2Bgamma/eIF-2Bepsilon) [cell envelope biogenesis, outer membrane / translation, ribosomal structure and biogenesis]
YP_001016138.1	COG1088 dTDP-D-glucose 4,6-dehydratase [cell envelope biogenesis, outer membrane]
YP_001016143.1	COG2604 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016146.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001016147.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001016149.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001016151.1	COG1566 Multidrug resistance efflux pump [Defense mechanisms]
YP_001016153.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001016156.1	COG1216 Predicted glycosyltransferases [general function prediction only]
YP_001016157.1	COG1134 ABC-type polysaccharide/polyol phosphate transporter, ATPase component [carbohydrate transport and metabolism / cell envelope biogenesis, outer membrane]
YP_001016158.1	COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease [carbohydrate transport and metabolism / cell envelope biogenesis, outer membrane]
YP_001016159.1	COG1208 nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/subunit epsilons (eIF-2Bgamma/eIF-2Bepsilon) [cell envelope biogenesis, outer membrane / translation, ribosomal structure an
YP_001016160.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016161.1	COG399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001016162.1	related to short-chain alcohol dehydrogenases; COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001016163.1	COG337 3-dehydroquinate synthetase [Amino acid transport and metabolism]
YP_001016164.1	COG28 thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001016166.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016167.1	COG1216 Predicted glycosyltransferases [general function prediction only]
YP_001016171.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins
YP_001016172.1	COG1045 serine acetyltransferase [Amino acid transport and metabolism]
YP_001016173.1	COG1725 Predicted transcriptional regulators [transcription]
YP_001016175.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_001016176.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_001016177.1	negatively supercoils closed circular double-stranded DNA
YP_001016179.1	COG239 integral membrane protein possibly involved in chromosome condensation [cell division and chromosome partitioning]
YP_001016180.1	COG239 integral membrane protein possibly involved in chromosome condensation [cell division and chromosome partitioning]
YP_001016182.1	COG386 glutathione peroxidase [Posttranslational modification, protein turnover, chaperones]
YP_001016183.1	COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) [inorganic ion transport and metabolism]
YP_001016184.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001016185.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [general function prediction only]
YP_001016186.1	COG841 Cation/multidrug efflux pump [Defense mechanisms]
YP_001016187.1	COG845 membrane-fusion protein [cell envelope biogenesis, outer membrane]
YP_001016189.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_001016190.1	COG479 succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]
YP_001016191.1	COG3491 Isopenicillin N synthase and related dioxygenases [general function prediction only]
YP_001016192.1	COG1194 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
YP_001016193.1	COG524 Sugar kinases, ribokinase family [carbohydrate transport and metabolism]
YP_001016194.1	COG802 Predicted ATPase or kinase [general function prediction only]
YP_001016195.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_001016197.1	COG586 Uncharacterized membrane-associated protein [Function unknown]
YP_001016198.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_001016199.1	functions in MreBCD complex in some organisms
YP_001016200.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_001016202.1	COG1653 ABC-type sugar transporter, periplasmic component [carbohydrate transport and metabolism]
YP_001016203.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001016204.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_001016208.1	COG4301 Uncharacterized conserved protein [Function unknown]
YP_001016209.1	COG1262 Uncharacterized conserved protein [Function unknown]
YP_001016211.1	COG515 serine/threonine protein kinase [general function prediction only / Signal transduction mechanisms / transcription / DNA replication, recombination, and repair]
YP_001016212.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_001016213.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_001016214.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016215.1	COG1473 metal-dependent amidase/aminoacylase/carboxypeptidase [general function prediction only]
YP_001016217.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_001016220.1	COG4446 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016225.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_001016226.1	COG720 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]
YP_001016227.1	COG1985 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]
YP_001016230.1	COG3146 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016233.1	COG1032 Fe-S oxidoreductase [Energy production and conversion]
YP_001016236.1	COG621 2-methylthioadenine synthetase [translation, ribosomal structure and biogenesis]
YP_001016237.1	COG4243 Predicted membrane protein [Function unknown]
YP_001016238.1	COG29 aspartate oxidase [Coenzyme metabolism]
YP_001016239.1	stabilizes and protects the oxygen-evolving complex of photosystem II against heat-induced inactivation
YP_001016241.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_001016242.1	COG1625 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]
YP_001016243.1	COG1538 Outer membrane protein [cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]
YP_001016244.1	COG483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [carbohydrate transport and metabolism]
YP_001016249.1	COG1295 Predicted membrane protein [Function unknown]
YP_001016258.1	COG1570 exonuclease VII, large subunit [DNA replication, recombination, and repair]
YP_001016261.1	COG1643 HrpA-like helicases [DNA replication, recombination, and repair]
YP_001016266.1	COG265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
YP_001016268.1	COG488 ATPase components of ABC transporters with duplicated ATPase domains [general function prediction only]
YP_001016273.1	distantly related to HSP70-fold metalloproteases; catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_001016274.1	COG569 K+ transporters, NAD-binding component [inorganic ion transport and metabolism]
YP_001016275.1	COG168 Trk-type K+ transporters, membrane components [inorganic ion transport and metabolism]
YP_001016276.1	COG471 Di- and tricarboxylate transporters [inorganic ion transport and metabolism]
YP_001016277.1	COG2262 GTPases [general function prediction only]
YP_001016278.1	COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
YP_001016279.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_001016280.1	COG1521  transcriptional regulator, homolog of Bvg accessory factor [transcription]
YP_001016281.1	COG1225 peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001016285.1	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]
YP_001016286.1	COG845 membrane-fusion protein [cell envelope biogenesis, outer membrane]
YP_001016287.1	COG3696  silver efflux pump [inorganic ion transport and metabolism]
YP_001016289.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_001016294.1	COG330 membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
YP_001016295.1	COG1585 membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001016297.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016301.1	COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
YP_001016308.1	COG4974 Site-specific recombinase XerD [DNA replication, recombination, and repair]
YP_001016312.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001016314.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001016315.1	COG1502 phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes [lipid metabolism]
YP_001016317.1	COG3330 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016318.1	COG2345 Predicted transcriptional regulator [transcription]
YP_001016320.1	with SufCD activates cysteine desulfurase SufS
YP_001016321.1	COG396 ABC-type transporter involved in Fe-S cluster assembly, ATPase component [Posttranslational modification, protein turnover, chaperones]
YP_001016322.1	COG719 ABC-type transporter involved in Fe-S cluster assembly, permease [Posttranslational modification, protein turnover, chaperones]
YP_001016323.1	COG520 Selenocysteine lyase [Amino acid transport and metabolism]
YP_001016324.1	COG1506 dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]
YP_001016327.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001016331.1	COG606 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]
YP_001016332.1	COG537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only]
YP_001016333.1	COG4178 ABC-type uncharacterized transporter, permease and ATPase components [general function prediction only]
YP_001016339.1	COG762 Predicted integral membrane protein [Function unknown]
YP_001016340.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_001016341.1	COG763 lipid A disaccharide synthetase [cell envelope biogenesis, outer membrane]
YP_001016342.1	COG229 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001016343.1	COG1873 Uncharacterized conserved protein [Function unknown]
YP_001016344.1	COG497 ATPase involved in DNA repair [DNA replication, recombination, and repair]
YP_001016353.1	COG116 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]
YP_001016355.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001016357.1	COG4252 Predicted transmembrane sensor domain [Signal transduction mechanisms]
YP_001016359.1	COG4995 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016370.1	COG3152 Predicted membrane protein [Function unknown]
YP_001016373.1	COG2124 cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001016377.1	COG3542 Uncharacterized conserved protein [Function unknown]
YP_001016380.1	COG1525 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]
YP_001016390.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001016394.1	COG1409 Predicted phosphohydrolases [general function prediction only]
YP_001016397.1	COG786 Na+/glutamate symporter [Amino acid transport and metabolism]
YP_001016401.1	COG492 thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]
YP_001016402.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_001016404.1	COG484 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
YP_001016405.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_001016406.1	COG1193 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]
YP_001016407.1	COG3839 ABC-type sugar transporters, ATPase components [carbohydrate transport and metabolism]
YP_001016411.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_001016416.1	COG488 ATPase components of ABC transporters with duplicated ATPase domains [general function prediction only]
YP_001016417.1	COG5413 Uncharacterized integral membrane protein [Function unknown]
YP_001016418.1	COG435 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001016419.1	catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate
YP_001016427.1	COG1808 Predicted membrane protein [Function unknown]
YP_001016430.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_001016431.1	COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination [transcription]
YP_001016432.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_001016433.1	COG779 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016434.1	COG668 Small-conductance mechanosensitive channel [cell envelope biogenesis, outer membrane]
YP_001016436.1	COG5361 Uncharacterized conserved protein [Function unknown]
YP_001016437.1	COG5361 Uncharacterized conserved protein [Function unknown]
YP_001016439.1	COG641 Arylsulfatase regulator (Fe-S oxidoreductase) [general function prediction only]
YP_001016442.1	COG834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]
YP_001016443.1	COG1262 Uncharacterized conserved protein [Function unknown]
YP_001016444.1	COG3119 Arylsulfatase A and related enzymes [inorganic ion transport and metabolism]
YP_001016448.1	COG265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
YP_001016449.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_001016450.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_001016451.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_001016452.1	COG84 Mg-dependent DNase [DNA replication, recombination, and repair]
YP_001016453.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; subunit beta is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_001016454.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_001016456.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_001016458.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_001016459.1	COG591 Na+/proline symporter [Amino acid transport and metabolism / general function prediction only]
YP_001016461.1	COG1413 FOG: HEAT repeat [Energy production and conversion]
YP_001016465.1	COG1141 Ferredoxin [Energy production and conversion]
YP_001016466.1	COG1453 Predicted oxidoreductases of the aldo/keto reductase family [general function prediction only]
YP_001016467.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_001016470.1	COG161 adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]
YP_001016473.1	COG132 Dethiobiotin synthetase [Coenzyme metabolism]
YP_001016474.1	involved in ubiquinone/menaquinone biosynthesis; COG2226 methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001016476.1	COG156 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]
YP_001016477.1	COG4581 Superfamily II RNA helicase [DNA replication, recombination, and repair]
YP_001016478.1	COG2271 Sugar phosphate permease [carbohydrate transport and metabolism]
YP_001016479.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_001016480.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_001016483.1	COG1189 Predicted rRNA methylase [translation, ribosomal structure and biogenesis]
YP_001016484.1	COG347 nitrogen regulatory protein PII [Amino acid transport and metabolism]
YP_001016487.1	NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis
YP_001016488.1	COG1333 ResB protein required for cytochrome C biosynthesis [Posttranslational modification, protein turnover, chaperones]
YP_001016489.1	COG785 cytochrome C biogenesis protein [Posttranslational modification, protein turnover, chaperones]
YP_001016490.1	COG772 Bacterial cell division membrane protein [cell division and chromosome partitioning]
YP_001016492.1	COG2230 Cyclopropane fatty acid synthase and related methyltransferases [cell envelope biogenesis, outer membrane]
YP_001016495.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_001016496.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_001016497.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_001016498.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.
YP_001016499.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the subunit delta is part of the catalytic core of the ATP synthase complex
YP_001016500.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_001016501.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_001016505.1	COG686 alanine dehydrogenase [Amino acid transport and metabolism]
YP_001016506.1	COG171 NAD synthase [Coenzyme metabolism]
YP_001016507.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_001016509.1	COG1100 GTPase SAR1 and related small G proteins [general function prediction only]
YP_001016510.1	COG1253 Hemolysins and related proteins containing CBS domains [general function prediction only]
YP_001016512.1	COG6 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
YP_001016514.1	COG546 Predicted phosphatases [general function prediction only]
YP_001016517.1	COG176 transaldolase [carbohydrate transport and metabolism]
YP_001016518.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_001016519.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_001016520.1	COG234 Co-chaperonin GroES (HSP10) [Posttranslational modification, protein turnover, chaperones]
YP_001016521.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001016525.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_001016526.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_001016527.1	COG443 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001016529.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and subunit alphas
YP_001016533.1	COG2947 Uncharacterized conserved protein [Function unknown]
YP_001016535.1	COG679 Predicted permeases [general function prediction only]
YP_001016538.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_001016539.1	COG2302 Uncharacterized conserved protein, contains S4-like domain [Function unknown]
YP_001016541.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_001016542.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_001016543.1	COG633 Ferredoxin [Energy production and conversion]
YP_001016548.1	low-potential cytochrome C; with PsbO, PsbP, PsbQ, and PsbU makes up the oxygen-evolving complex of photosystem II
YP_001016550.1	COG1234 metal-dependent hydrolases of the beta-lactamase superfamily III [general function prediction only]
YP_001016552.1	COG2385 sporulation protein and related proteins [cell division and chromosome partitioning]
YP_001016553.1	COG363 6-phosphogluconolactonase/glucosamine-6-phosphate isomerase/deaminase [carbohydrate transport and metabolism]
YP_001016555.1	COG217 Uncharacterized conserved protein [Function unknown]
YP_001016556.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_001016557.1	involved in the peptidyltransferase reaction during translation
YP_001016558.1	COG261 ribosomal protein L21 [translation, ribosomal structure and biogenesis]
YP_001016560.1	Decreases the phosphorylation of KaiC, a component of the main circadian regulator in cyanobacteria
YP_001016561.1	acts as a promotor non-specific transcription repressor
YP_001016562.1	COG5002 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001016563.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_001016565.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_001016566.1	chloroplast outer envelope membrane protein-like protein; COG4775 Outer membrane protein/protective antigen OMA87 [cell envelope biogenesis, outer membrane]
YP_001016567.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_001016568.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_001016569.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_001016570.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_001016571.1	COG225 peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001016574.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_001016576.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001016578.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_001016579.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_001016580.1	COG344 Predicted membrane protein [Function unknown]
YP_001016584.1	COG767 ABC-type transporter involved in resistance to organic solvents, permease [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001016585.1	COG2211 Na+/melibiose symporter and related transporters [carbohydrate transport and metabolism]
YP_001016586.1	COG1523 type II secretory pathway, pullulanase PulA and related glycosidases [carbohydrate transport and metabolism]
YP_001016588.1	COG776 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]
YP_001016594.1	COG397 Uncharacterized conserved protein [Function unknown]
YP_001016606.1	COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold [general function prediction only]
YP_001016612.1	COG432 Uncharacterized conserved protein [Function unknown]
YP_001016617.1	COG313 Predicted methyltransferases [general function prediction only]
YP_001016618.1	COG1218 3'-phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [inorganic ion transport and metabolism]
YP_001016619.1	COG1185 polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [translation, ribosomal structure and biogenesis]
YP_001016620.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_001016622.1	COG750 Predicted membrane-associated Zn-dependent proteases 1 [cell envelope biogenesis, outer membrane]
YP_001016623.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001016624.1	COG464 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
YP_001016625.1	COG1399 Predicted metal-binding, possibly nucleic acid-binding protein [general function prediction only]
YP_001016626.1	similar to 60 kDa inner membrane protein family; functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_001016628.1	COG594 RNase P protein component [translation, ribosomal structure and biogenesis]
YP_001016629.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_001016631.1	COG4401 chorismate mutase [Amino acid transport and metabolism]
YP_001016632.1	COG616 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001016633.1	pecM homolog; COG697 Permeases of the drug/metabolite transporter (DMT) superfamily [carbohydrate transport and metabolism / Amino acid transport and metabolism / general function prediction only]
YP_001016634.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [cell envelope biogenesis, outer membrane]
YP_001016638.1	chloroplast membrane-associated 30 kDa protein-like protein; COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [transcription / Signal transduction mechanisms]
YP_001016639.1	COG436 aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
YP_001016640.1	COG340 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]
YP_001016643.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001016644.1	COG784 FOG: CheY-like receiver [Signal transduction mechanisms]
YP_001016645.1	COG1136 ABC-type antimicrobial peptide transporter, ATPase component [Defense mechanisms]
YP_001016646.1	transfers electrons from NAD(P)H to quinons in the respiratory chain
YP_001016647.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_001016649.1	COG4241 Predicted membrane protein [Function unknown]
YP_001016650.1	COG2038 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]
YP_001016652.1	COG1453 Predicted oxidoreductases of the aldo/keto reductase family [general function prediction only]
YP_001016653.1	COG1259 Uncharacterized conserved protein [Function unknown]
YP_001016654.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_001016655.1	COG3247 Uncharacterized conserved protein [Function unknown]
YP_001016657.1	COG1845 Heme/copper-type cytochrome/quinol oxidase subunit 3 [Energy production and conversion]
YP_001016658.1	COG843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]
YP_001016659.1	COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]
YP_001016661.1	COG1612 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]
YP_001016662.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_001016663.1	COG1131 ABC-type multidrug transporter, ATPase component [Defense mechanisms]
YP_001016666.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_001016667.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_001016669.1	COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001016670.1	COG569 K+ transporters, NAD-binding component [inorganic ion transport and metabolism]
YP_001016671.1	COG859 ADP-heptose:LPS heptosyltransferase [cell envelope biogenesis, outer membrane]
YP_001016672.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_001016674.1	COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF [Defense mechanisms]
YP_001016675.1	UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin
YP_001016676.1	COG248 Exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism]
YP_001016677.1	COG1426 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016678.1	COG2875 precorrin-4 methylase [Coenzyme metabolism]
YP_001016679.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_001016680.1	cytochrome f, with cytochrome b6, subunit IV, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001016681.1	Rieske protein, with cytochrome b6, cytochrome f, and subunit IV, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001016682.1	COG805 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]
YP_001016683.1	COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP [transcription]
YP_001016684.1	Essential for recycling GMP and indirectly, cGMP
YP_001016685.1	Enables the organization of the psaE and psaF subunits
YP_001016687.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_001016690.1	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT [cell motility and secretion / Intracellular trafficking and secretion]
YP_001016691.1	COG381 UDP-N-acetylglucosamine 2-epimerase [cell envelope biogenesis, outer membrane]
YP_001016692.1	COG4333 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016694.1	COG25 NhaP-type Na+/H+ and K+/H+ antiporters [inorganic ion transport and metabolism]
YP_001016695.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001016698.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_001016700.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential
YP_001016701.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016703.1	COG857 BioD-like N-terminal domain of phosphotransacetylase [general function prediction only]
YP_001016705.1	COG1585 membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001016706.1	COG330 membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
YP_001016710.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_001016711.1	COG154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase subunit alpha and related amidases [translation, ribosomal structure and biogenesis]
YP_001016712.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_001016713.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001016714.1	COG708 exonuclease III [DNA replication, recombination, and repair]
YP_001016719.1	COG1641 Uncharacterized conserved protein [Function unknown]
YP_001016724.1	COG1178 ABC-type Fe3+ transporter, permease component [inorganic ion transport and metabolism]
YP_001016728.1	COG523  GTPases (G3E family) [general function prediction only]
YP_001016729.1	4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction
YP_001016731.1	COG432 Uncharacterized conserved protein [Function unknown]
YP_001016733.1	COG3011 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016734.1	COG2317 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]
YP_001016741.1	COG221 inorganic pyrophosphatase [Energy production and conversion]
YP_001016742.1	COG1376 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016743.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_001016745.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_001016747.1	COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]
YP_001016750.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_001016753.1	COG629 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]
YP_001016754.1	COG2099 precorrin-6x reductase [Coenzyme metabolism]
YP_001016756.1	COG1324 Uncharacterized protein involved in tolerance to divalent cations [inorganic ion transport and metabolism]
YP_001016757.1	COG524 Sugar kinases, ribokinase family [carbohydrate transport and metabolism]
YP_001016758.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_001016760.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_001016763.1	COG221 inorganic pyrophosphatase [Energy production and conversion]
YP_001016764.1	COG1393 Arsenate reductase and related proteins, glutaredoxin family [inorganic ion transport and metabolism]
YP_001016767.1	COG681 Signal peptidase I [Intracellular trafficking and secretion]
YP_001016768.1	COG44 dihydroorotase and related cyclic amidohydrolases [nucleotide transport and metabolism]
YP_001016769.1	COG406 fructose-2,6-bisphosphatase [carbohydrate transport and metabolism]
YP_001016770.1	COG1266 Predicted metal-dependent membrane protease [general function prediction only]
YP_001016772.1	COG768 cell division protein FtsI/penicillin-binding protein 2 [cell envelope biogenesis, outer membrane]
YP_001016773.1	maintains the balance of metabolites in the pentose-phosphate pathway
YP_001016775.1	COG300 Short-chain dehydrogenases of various substrate specificities [general function prediction only]
YP_001016776.1	COG644 dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001016777.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_001016778.1	Catalyzes the phosphorylation of UMP to UDP
YP_001016779.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001016780.1	COG2226 methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001016782.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_001016784.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_001016787.1	COG683 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]
YP_001016788.1	COG2509 Uncharacterized FAD-dependent dehydrogenases [general function prediction only]
YP_001016789.1	COG1496 Uncharacterized conserved protein [Function unknown]
YP_001016791.1	COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain) [translation, ribosomal structure and biogenesis]
YP_001016794.1	COG1402 Uncharacterized protein,  amidase [general function prediction only]
YP_001016798.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_001016799.1	COG4221 Short-chain alcohol dehydrogenase of unknown specificity [general function prediction only]
YP_001016800.1	COG302 GTP cyclohydrolase I [Coenzyme metabolism]
YP_001016802.1	COG135 phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]
YP_001016803.1	COG1994 Zn-dependent proteases [general function prediction only]
YP_001016804.1	COG95 Lipoate-protein ligase A [Coenzyme metabolism]
YP_001016805.1	COG730 Predicted permeases [general function prediction only]
YP_001016808.1	Converts chlorophyllide a into protochlorophyllide; light dependent
YP_001016809.1	light-independent; with chlN(bchN) and chlB(bchB) reduces ring D of protochlorophyllide to form chlorophyllide a in chlorophyll/bacteriochlorophyll production
YP_001016810.1	light-independent reduction of protochlorophyllide to form chlorophyllide a
YP_001016811.1	light-independent reduction of protochlorophyllide to form chlorophyllide a
YP_001016812.1	COG659 sulfate permease and related transporters (MFS superfamily) [inorganic ion transport and metabolism]
YP_001016813.1	COG3329 Predicted permease [general function prediction only]
YP_001016821.1	COG127 Xanthosine triphosphate pyrophosphatase [nucleotide transport and metabolism]
YP_001016823.1	COG4577 carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001016824.1	type III RuBisCO; involved in carbon fixation
YP_001016825.1	COG4451 ribulose bisphosphate carboxylase small subunit [Energy production and conversion]
YP_001016829.1	COG4576 carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001016830.1	COG4576 carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001016832.1	COG2154 Pterin-4a-carbinolamine dehydratase [Coenzyme metabolism]
YP_001016836.1	COG251  translation initiation inhibitor, yjgF family [translation, ribosomal structure and biogenesis]
YP_001016838.1	COG491 Zn-dependent hydrolases, including glyoxylases [general function prediction only]
YP_001016839.1	short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ
YP_001016840.1	COG1132 ABC-type multidrug transporter, ATPase and permeases [Defense mechanisms]
YP_001016841.1	COG456 acetyltransferases [general function prediction only]
YP_001016844.1	COG3222 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016845.1	typically periplasmic containing C-terminal PDZ domain; COG265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
YP_001016846.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_001016847.1	COG678 peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001016848.1	COG3315 O-methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001016852.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_001016854.1	COG424 nucleotide-binding protein implicated in inhibition of septum formation [cell division and chromosome partitioning]
YP_001016855.1	COG668 Small-conductance mechanosensitive channel [cell envelope biogenesis, outer membrane]
YP_001016856.1	COG1653 ABC-type sugar transporter, periplasmic component [carbohydrate transport and metabolism]
YP_001016861.1	required for the assembly of photosystem I complex
YP_001016862.1	COG652 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001016863.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_001016864.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [general function prediction only]
YP_001016865.1	COG1867 N2,N2-dimethylguanosine tRNA methyltransferase [translation, ribosomal structure and biogenesis]
YP_001016866.1	Ycf31; cytochrome b6-f complex subunit 7; with PetL, PetG and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001016867.1	COG702 Predicted nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001016870.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [translation, ribosomal structure and biogenesis]
YP_001016871.1	COG361 translation initiation factor 1 (IF-1) [translation, ribosomal structure and biogenesis]
YP_001016873.1	COG1061 DNA or RNA helicases of superfamily II [transcription / DNA replication, recombination, and repair]
YP_001016876.1	COG3288 NAD/NADP transhydrogenase subunit alpha [Energy production and conversion]
YP_001016878.1	COG1282 NAD/NADP transhydrogenase subunit beta [Energy production and conversion]
YP_001016879.1	COG429 Predicted hydrolase of the alpha/beta-hydrolase fold [general function prediction only]
YP_001016880.1	COG3411 Ferredoxin [Energy production and conversion]
YP_001016881.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_001016882.1	COG733 Na+-dependent transporters of the SNF family [general function prediction only]
YP_001016883.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_001016884.1	COG5031 Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]
YP_001016885.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_001016886.1	COG845 membrane-fusion protein [cell envelope biogenesis, outer membrane]
YP_001016887.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_001016900.1	COG4188 Predicted dienelactone hydrolase [general function prediction only]
YP_001016901.1	COG601 ABC-type dipeptide/oligopeptide/nickel transport systems, permeases [Amino acid transport and metabolism / inorganic ion transport and metabolism]
YP_001016902.1	COG747 ABC-type dipeptide transporter, periplasmic component [Amino acid transport and metabolism]
YP_001016904.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_001016905.1	COG2166 SufE protein probably involved in Fe-S center assembly [general function prediction only]
YP_001016908.1	COG212 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]
YP_001016909.1	COG2226 methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001016910.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_001016911.1	COG1239 Mg-chelatase subunit ChlI [Coenzyme metabolism]
YP_001016913.1	COG2367 beta-lactamase class A [Defense mechanisms]
YP_001016914.1	COG565 rRNA methylase [translation, ribosomal structure and biogenesis]
YP_001016926.1	COG742 N6-adenine-specific methylase [DNA replication, recombination, and repair]
YP_001016927.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_001016928.1	COG526 thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]
YP_001016929.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_001016931.1	negatively supercoils closed circular double-stranded DNA
YP_001016932.1	COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
YP_001016933.1	COG1543 Uncharacterized conserved protein [Function unknown]
YP_001016934.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_001016935.1	COG395 ABC-type sugar transporter, permease component [carbohydrate transport and metabolism]
YP_001016945.1	similar to Hepatitis C virus core protein
YP_001016946.1	COG564 Pseudouridylate synthases, 23S RNA-specific [translation, ribosomal structure and biogenesis]
YP_001016947.1	COG1480 Predicted membrane-associated HD superfamily hydrolase [general function prediction only]
YP_001016948.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_001016949.1	COG142 geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
YP_001016950.1	COG1963 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001016953.1	COG406 fructose-2,6-bisphosphatase [carbohydrate transport and metabolism]
YP_001016954.1	COG1797 cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]
YP_001016955.1	COG3429 glucose-6-P dehydrogenase subunit [carbohydrate transport and metabolism]
YP_001016956.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_001016957.1	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]
YP_001016959.1	interacts with the circadian clock regulator KaiC to maintain circadian rhythms
YP_001016965.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001016968.1	COG278 glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]
YP_001016969.1	COG271 stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
YP_001016971.1	from 'motifs_6.msf'; COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [lipid metabolism]
YP_001016972.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_001016975.1	COG1330 exonuclease V subunit gamma [DNA replication, recombination, and repair]
YP_001016976.1	COG2020  protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]
YP_001016977.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001016978.1	COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]
YP_001016980.1	COG662 mannose-6-phosphate isomerase [carbohydrate transport and metabolism]
YP_001016981.1	COG513 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / transcription / translation, ribosomal structure and biogenesis]
YP_001016985.1	COG1316 transcriptional regulator [transcription]
YP_001016987.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_001016988.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001016990.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_001016992.1	COG1316 transcriptional regulator [transcription]
YP_001016993.1	amylomaltase; acts to release glucose from maltodextrins
YP_001016997.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [translation, ribosomal structure and biogenesis]
YP_001016998.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001016999.1	COG661 Predicted unusual protein kinase [general function prediction only]
YP_001017000.1	COG1982 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]
YP_001017001.1	COG575 CDP-diglyceride synthetase [lipid metabolism]
YP_001017003.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [general function prediction only]
YP_001017004.1	COG371 glycerol dehydrogenase and related enzymes [Energy production and conversion]
YP_001017005.1	COG542 ATPases with chaperone activity, ATP-binding subunit [Posttranslational modification, protein turnover, chaperones]
YP_001017006.1	COG456 acetyltransferases [general function prediction only]
YP_001017007.1	COG19 diaminopimelate decarboxylase [Amino acid transport and metabolism]
YP_001017008.1	COG1624 Uncharacterized conserved protein [Function unknown]
YP_001017009.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_001017010.1	COG502 Biotin synthase and related enzymes [Coenzyme metabolism]
YP_001017011.1	COG1054 Predicted sulfurtransferase [general function prediction only]
YP_001017013.1	COG1649 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017014.1	COG308 Aminopeptidase N [Amino acid transport and metabolism]
YP_001017015.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001017016.1	TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine
YP_001017017.1	component of photosystem II; manganese-binding polypeptide with arginine metablolizing activity
YP_001017031.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001017039.1	COG1765 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]
YP_001017048.1	COG4446 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017050.1	COG2343 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017051.1	COG412 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001017054.1	COG2095 Multiple antibiotic transporter [Intracellular trafficking and secretion]
YP_001017055.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_001017075.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_001017094.1	COG1225 peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001017097.1	COG531 Amino acid transporters [Amino acid transport and metabolism]
YP_001017100.1	COG1020 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001017113.1	COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]
YP_001017118.1	COG640 Predicted transcriptional regulators [transcription]
YP_001017119.1	COG57 glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [carbohydrate transport and metabolism]
YP_001017121.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001017122.1	COG226 ABC-type phosphate transporter, periplasmic component [inorganic ion transport and metabolism]
YP_001017124.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001017126.1	COG1108 ABC-type Mn2+/Zn2+ transporters, permease components [inorganic ion transport and metabolism]
YP_001017127.1	COG1121 ABC-type Mn/Zn transporters, ATPase component [inorganic ion transport and metabolism]
YP_001017128.1	COG803 ABC-type metal ion transporter, periplasmic component/surface adhesin [inorganic ion transport and metabolism]
YP_001017130.1	COG523  GTPases (G3E family) [general function prediction only]
YP_001017131.1	COG2319 FOG: WD40 repeat [general function prediction only]
YP_001017138.1	COG2059 Chromate transporter ChrA [inorganic ion transport and metabolism]
YP_001017139.1	COG4341 Predicted HD phosphohydrolase [general function prediction only]
YP_001017141.1	COG1052 lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / general function prediction only]
YP_001017142.1	COG3639 ABC-type phosphate/phosphonate transporter, permease [inorganic ion transport and metabolism]
YP_001017143.1	COG3221 ABC-type phosphate/phosphonate transporter, periplasmic component [inorganic ion transport and metabolism]
YP_001017144.1	COG3638 ABC-type phosphate/phosphonate transporter, ATPase component [inorganic ion transport and metabolism]
YP_001017145.1	COG798 Arsenite efflux pump ACR3 and related permeases [inorganic ion transport and metabolism]
YP_001017170.1	DNA polymerase (viral) N-terminal domain
YP_001017174.1	COG3651 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017186.1	COG1404 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]
YP_001017197.1	COG3349 Uncharacterized conserved protein [Function unknown]
YP_001017202.1	COG5470 Uncharacterized conserved protein [Function unknown]
YP_001017219.1	COG4095 Uncharacterized conserved protein [Function unknown]
YP_001017224.1	COG1126 ABC-type polar amino acid transporter, ATPase component [Amino acid transport and metabolism]
YP_001017225.1	COG765 ABC-type amino acid transporter, permease component [Amino acid transport and metabolism]
YP_001017227.1	COG3247 Uncharacterized conserved protein [Function unknown]
YP_001017228.1	COG765 ABC-type amino acid transporter, permease component [Amino acid transport and metabolism]
YP_001017229.1	COG834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]
YP_001017232.1	COG659 sulfate permease and related transporters (MFS superfamily) [inorganic ion transport and metabolism]
YP_001017233.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001017235.1	COG2138 Uncharacterized conserved protein [Function unknown]
YP_001017239.1	COG2303 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]
YP_001017246.1	COG330 membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
YP_001017247.1	COG1301 Na+/H+-dicarboxylate symporters [Energy production and conversion]
YP_001017252.1	COG524 Sugar kinases, ribokinase family [carbohydrate transport and metabolism]
YP_001017260.1	COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [cell envelope biogenesis, outer membrane]
YP_001017264.1	COG4095 Uncharacterized conserved protein [Function unknown]
YP_001017291.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001017313.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001017315.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001017326.1	COG3145 Alkylated DNA repair protein [DNA replication, recombination, and repair]
YP_001017327.1	COG2187 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017328.1	COG3325 chitinase [carbohydrate transport and metabolism]
YP_001017330.1	COG1897 homoserine trans-succinylase [Amino acid transport and metabolism]
YP_001017331.1	COG2873 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]
YP_001017335.1	COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001017341.1	COG420 DNA repair exonuclease [DNA replication, recombination, and repair]
YP_001017342.1	COG419 ATPase involved in DNA repair [DNA replication, recombination, and repair]
YP_001017346.1	COG535 Predicted Fe-S oxidoreductases [general function prediction only]
YP_001017347.1	COG1799 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017351.1	COG735 Fe2+/Zn2+ uptake regulation proteins [inorganic ion transport and metabolism]
YP_001017355.1	COG1970 Large-conductance mechanosensitive channel [cell envelope biogenesis, outer membrane]
YP_001017356.1	COG1535 Isochorismate hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001017357.1	COG668 Small-conductance mechanosensitive channel [cell envelope biogenesis, outer membrane]
YP_001017358.1	COG1808 Predicted membrane protein [Function unknown]
YP_001017375.1	COG4318 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017382.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001017393.1	COG4448 L-asparaginase II [Amino acid transport and metabolism]
YP_001017394.1	COG799 Uncharacterized homolog of plant Iojap protein [Function unknown]
YP_001017396.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_001017401.1	COG1132 ABC-type multidrug transporter, ATPase and permeases [Defense mechanisms]
YP_001017402.1	COG2501 Uncharacterized conserved protein [Function unknown]
YP_001017403.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_001017405.1	catalyzes the formation of Mg-protoporphyrin IX from protoporphyrin IX and Mg(2+); first committed step of chlorophyll biosynthesis
YP_001017406.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_001017409.1	COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
YP_001017411.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_001017416.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001017417.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001017418.1	COG2326 Uncharacterized conserved protein [Function unknown]
YP_001017420.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_001017423.1	COG518 GMP synthase - glutamine amidotransferase domain [nucleotide transport and metabolism]
YP_001017424.1	COG3239 Fatty acid desaturase [lipid metabolism]
YP_001017430.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_001017434.1	COG1122 ABC-type cobalt transporter, ATPase component [inorganic ion transport and metabolism]
YP_001017436.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_001017437.1	COG1836 Predicted membrane protein [Function unknown]
YP_001017438.1	COG1191 DNA-directed RNA polymerase specialized sigma subunit [transcription]
YP_001017439.1	COG2755 lysophospholipase L1 and related esterases [Amino acid transport and metabolism]
YP_001017440.1	COG3639 ABC-type phosphate/phosphonate transporter, permease [inorganic ion transport and metabolism]
YP_001017441.1	COG3638 ABC-type phosphate/phosphonate transporter, ATPase component [inorganic ion transport and metabolism]
YP_001017442.1	COG3221 ABC-type phosphate/phosphonate transporter, periplasmic component [inorganic ion transport and metabolism]
YP_001017443.1	COG436 aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
YP_001017444.1	COG1573 uracil-DNA glycosylase [DNA replication, recombination, and repair]
YP_001017445.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_001017446.1	COG793 Periplasmic protease [cell envelope biogenesis, outer membrane]
YP_001017448.1	COG1197 transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / transcription]
YP_001017449.1	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [inorganic ion transport and metabolism / general function prediction only]
YP_001017451.1	COG223 Methionyl-tRNA formyltransferase [translation, ribosomal structure and biogenesis]
YP_001017452.1	COG312 Predicted Zn-dependent proteases and their inactivated homologs [general function prediction only]
YP_001017453.1	COG312 Predicted Zn-dependent proteases and their inactivated homologs [general function prediction only]
YP_001017457.1	COG163 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]
YP_001017458.1	COG557 Exoribonuclease R [transcription]
YP_001017461.1	COG727 Predicted Fe-S-cluster oxidoreductase [general function prediction only]
YP_001017462.1	COG38 chloride channel protein EriC [inorganic ion transport and metabolism]
YP_001017463.1	COG608 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]
YP_001017465.1	COG637 Predicted phosphatase/phosphohexomutase [general function prediction only]
YP_001017467.1	COG4240 Predicted kinase [general function prediction only]
YP_001017468.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_001017470.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001017472.1	COG1615 Uncharacterized conserved protein [Function unknown]
YP_001017473.1	COG450 peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001017475.1	COG739 membrane proteins related to metalloendopeptidases [cell envelope biogenesis, outer membrane]
YP_001017477.1	COG739 membrane proteins related to metalloendopeptidases [cell envelope biogenesis, outer membrane]
YP_001017478.1	COG219 Predicted rRNA methylase (SpoU class) [translation, ribosomal structure and biogenesis]
YP_001017479.1	COG2087 adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]
YP_001017480.1	involved in light-induced Na+-dependent proton extrusion
YP_001017481.1	COG1512 beta-propeller domains of methanol dehydrogenase type [general function prediction only]
YP_001017485.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_001017488.1	COG557 Exoribonuclease R [transcription]
YP_001017489.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_001017491.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_001017492.1	related to tRNA (uracil-5-)-methyltransferase; COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [translation, ribosomal structure and biogenesis]
YP_001017495.1	COG1191 DNA-directed RNA polymerase specialized sigma subunit [transcription]
YP_001017496.1	COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [nucleotide transport and metabolism]
YP_001017500.1	COG1410 methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
YP_001017501.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_001017502.1	COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]
YP_001017503.1	COG613 Predicted metal-dependent phosphoesterases (PHP family) [general function prediction only]
YP_001017504.1	COG1981 Predicted membrane protein [Function unknown]
YP_001017505.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_001017506.1	COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [general function prediction only]
YP_001017507.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_001017509.1	COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [cell envelope biogenesis, outer membrane]
YP_001017513.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_001017515.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_001017516.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_001017519.1	COG3975 Predicted protease with the C-terminal PDZ domain [general function prediction only]
YP_001017520.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_001017521.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_001017522.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; note this protein has an additional C-terminal tail of unknown function as compared to similar bifunctional enzymes
YP_001017523.1	COG652 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001017524.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_001017526.1	COG2214 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001017527.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001017528.1	COG573 ABC-type phosphate transporter, permease component [inorganic ion transport and metabolism]
YP_001017529.1	COG581 ABC-type phosphate transporter, permease component [inorganic ion transport and metabolism]
YP_001017530.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_001017531.1	COG483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [carbohydrate transport and metabolism]
YP_001017532.1	May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YP_001017533.1	COG1146 Ferredoxin [Energy production and conversion]
YP_001017534.1	molecular chaperone
YP_001017535.1	required for 70S ribosome assembly
YP_001017537.1	COG1653 ABC-type sugar transporter, periplasmic component [carbohydrate transport and metabolism]
YP_001017538.1	COG1175 ABC-type sugar transporters, permease components [carbohydrate transport and metabolism]
YP_001017539.1	COG395 ABC-type sugar transporter, permease component [carbohydrate transport and metabolism]
YP_001017540.1	COG3839 ABC-type sugar transporters, ATPase components [carbohydrate transport and metabolism]
YP_001017541.1	COG2327 Uncharacterized conserved protein [Function unknown]
YP_001017545.1	COG644 dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001017546.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_001017547.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_001017548.1	COG1386 Predicted transcriptional regulator containing the HTH domain [transcription]
YP_001017549.1	COG762 Predicted integral membrane protein [Function unknown]
YP_001017551.1	COG1694 Predicted pyrophosphatase [general function prediction only]
YP_001017552.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_001017553.1	COG577 ABC-type antimicrobial peptide transporter, permease [Defense mechanisms]
YP_001017554.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001017555.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; in Synechococcus this protein (ClpP1)is constitutive and levels increased with the increase of light.
YP_001017556.1	Psb29; involved in biogenesis of the photosystem II; in Arabidopsis it interacts with the heterotrimeric G-protein (GPA1) and seems to be involved in a D-glucose signaling mechanism between plastid and the plasma membranes
YP_001017560.1	subunit VIII; plays a crucial role in complex assembly and/or stability; with PetL, PetG and PetM makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001017561.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_001017564.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_001017565.1	COG1175 ABC-type sugar transporters, permease components [carbohydrate transport and metabolism]
YP_001017566.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_001017567.1	COG1565 Uncharacterized conserved protein [Function unknown]
YP_001017569.1	COG4678 Muramidase (phage lambda lysozyme) [carbohydrate transport and metabolism]
YP_001017572.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_001017575.1	COG1119 ABC-type molybdenum transporter, ATPase component/photorepair protein PhrA [inorganic ion transport and metabolism]
YP_001017578.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001017580.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001017582.1	COG1538 Outer membrane protein [cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]
YP_001017584.1	COG1132 ABC-type multidrug transporter, ATPase and permeases [Defense mechanisms]
YP_001017585.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001017586.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_001017587.1	COG1366 anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]
YP_001017588.1	COG1939 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017589.1	COG566 rRNA methylases [translation, ribosomal structure and biogenesis]
YP_001017591.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001017592.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_001017594.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_001017595.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_001017599.1	COG1462 Uncharacterized protein involved in formation of curli polymers [cell envelope biogenesis, outer membrane]
YP_001017600.1	synthesizes RNA primers at the replication forks
YP_001017601.1	COG2192 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]
YP_001017605.1	COG389 nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]
YP_001017609.1	COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [transcription / Signal transduction mechanisms]
YP_001017612.1	COG1576 Uncharacterized conserved protein [Function unknown]
YP_001017616.1	COG4337 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017617.1	COG607 Rhodanese-related sulfurtransferase [inorganic ion transport and metabolism]
YP_001017623.1	COG792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]
YP_001017624.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_001017626.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_001017627.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_001017630.1	COG22 pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type subunit beta [Energy production and conversion]
YP_001017631.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_001017632.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_001017639.1	COG2226 methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001017644.1	COG2172 anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]
YP_001017646.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_001017647.1	PsbW; part of the phosystem II reaction center
YP_001017648.1	COG628 Predicted permease [general function prediction only]
YP_001017649.1	COG628 Predicted permease [general function prediction only]
YP_001017651.1	COG174 glutamine synthetase [Amino acid transport and metabolism]
YP_001017654.1	COG75 serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]
YP_001017655.1	COG590 cytosine/adenosine deaminases [nucleotide transport and metabolism / translation, ribosomal structure and biogenesis]
YP_001017658.1	COG76 glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]
YP_001017659.1	COG1100 GTPase SAR1 and related small G proteins [general function prediction only]
YP_001017662.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_001017663.1	COG1268 Uncharacterized conserved protein [general function prediction only]
YP_001017665.1	COG612 Predicted Zn-dependent peptidases [general function prediction only]
YP_001017666.1	COG612 Predicted Zn-dependent peptidases [general function prediction only]
YP_001017667.1	catalyzes the reduction of biliverdin IX-alpha producing (3Z)-phycocyanobilin and oxidized ferredoxin
YP_001017668.1	COG1566 Multidrug resistance efflux pump [Defense mechanisms]
YP_001017669.1	COG577 ABC-type antimicrobial peptide transporter, permease [Defense mechanisms]
YP_001017670.1	COG1136 ABC-type antimicrobial peptide transporter, ATPase component [Defense mechanisms]
YP_001017672.1	COG1216 Predicted glycosyltransferases [general function prediction only]
YP_001017673.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_001017674.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_001017676.1	catalyzes branch migration in Holliday junction intermediates
YP_001017679.1	COG2173 D-alanyl-D-alanine dipeptidase [cell envelope biogenesis, outer membrane]
YP_001017680.1	hemoprotein; NADPH dependent; with the subunit alpha (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_001017681.1	COG751 glycyl-tRNA synthetase subunit beta [translation, ribosomal structure and biogenesis]
YP_001017682.1	COG644 dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001017684.1	COG1876 D-alanyl-D-alanine carboxypeptidase [cell envelope biogenesis, outer membrane]
YP_001017685.1	COG1217 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]
YP_001017687.1	COG1934 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017688.1	COG1137 ABC-type (unclassified) transporter, ATPase component [general function prediction only]
YP_001017689.1	COG795 Predicted permeases [general function prediction only]
YP_001017690.1	COG755 ABC-type transporter involved in cytochrome C biogenesis, permease [Posttranslational modification, protein turnover, chaperones]
YP_001017691.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_001017692.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_001017693.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_001017694.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_001017696.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_001017697.1	COG363 6-phosphogluconolactonase/glucosamine-6-phosphate isomerase/deaminase [carbohydrate transport and metabolism]
YP_001017701.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_001017703.1	COG35 uracil phosphoribosyltransferase [nucleotide transport and metabolism]
YP_001017705.1	COG523  GTPases (G3E family) [general function prediction only]
YP_001017706.1	COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]
YP_001017707.1	COG4176 ABC-type proline/glycine betaine transport system, permease [Amino acid transport and metabolism]
YP_001017708.1	COG4175 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]
YP_001017716.1	COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001017719.1	COG2859 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017727.1	COG1215 glycosyltransferases, probably involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001017728.1	COG25 NhaP-type Na+/H+ and K+/H+ antiporters [inorganic ion transport and metabolism]
YP_001017730.1	COG674 pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, subunit alpha [Energy production and conversion]
YP_001017731.1	COG786 Na+/glutamate symporter [Amino acid transport and metabolism]
YP_001017733.1	COG1828 phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [nucleotide transport and metabolism]
YP_001017734.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001017735.1	COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF [Defense mechanisms]
YP_001017736.1	COG673 Predicted dehydrogenases and related proteins [general function prediction only]
YP_001017738.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_001017739.1	COG1989 type II secretory pathway, prepilin signal peptidase PulO and related peptidases [cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001017740.1	COG3954 phosphoribulokinase [Energy production and conversion]
YP_001017741.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_001017742.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_001017743.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_001017744.1	COG2179 Predicted hydrolase of the HAD superfamily [general function prediction only]
YP_001017746.1	Holliday junction resolvase in Mycoplasmas and B. subtilis; COG816 Predicted endonuclease involved in recombination ( Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]
YP_001017752.1	COG735 Fe2+/Zn2+ uptake regulation proteins [inorganic ion transport and metabolism]
YP_001017753.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_001017754.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001017755.1	COG558 phosphatidylglycerophosphate synthase [lipid metabolism]
YP_001017757.1	COG517 FOG: CBS domain [general function prediction only]
YP_001017762.1	COG695 glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]
YP_001017765.1	COG2010 cytochrome C, mono- and diheme variants [Energy production and conversion]
YP_001017766.1	COG226 ABC-type phosphate transporter, periplasmic component [inorganic ion transport and metabolism]
YP_001017768.1	COG702 Predicted nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001017771.1	COG177 Predicted endoIII-related endonuclease [DNA replication, recombination, and repair]
YP_001017774.1	COG3842 ABC-type spermidine/putrescine transporters, ATPase components [Amino acid transport and metabolism]
YP_001017776.1	COG1528 Ferritin-like protein [inorganic ion transport and metabolism]
YP_001017777.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001017781.1	COG1528 Ferritin-like protein [inorganic ion transport and metabolism]
YP_001017784.1	COG225 peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001017785.1	COG1506 dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]
YP_001017803.1	COG1028 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001017811.1	COG76 glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]
YP_001017814.1	COG625 glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001017816.1	COG1249 pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]
YP_001017818.1	COG530 Ca2+/Na+ antiporter [inorganic ion transport and metabolism]
YP_001017820.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_001017823.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_001017825.1	unknown function; YciI from Haemophilus influenzae has a crystal structure similar to a muconolactone isomerase, but does not seem to catalyze any of the reactions predicted from the sequence or structure similarity
YP_001017828.1	COG3431 Predicted membrane protein [Function unknown]
YP_001017831.1	COG3339 Uncharacterized conserved protein [Function unknown]
YP_001017832.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001017834.1	COG3556 Predicted membrane protein [Function unknown]
YP_001017836.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_001017838.1	COG720 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]
YP_001017839.1	COG542 ATPases with chaperone activity, ATP-binding subunit [Posttranslational modification, protein turnover, chaperones]
YP_001017841.1	participates in electron transfer in photosystem I
YP_001017842.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001017843.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_001017844.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_001017846.1	COG2936 Predicted acyl esterases [general function prediction only]
YP_001017851.1	COG1940 transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism]
YP_001017852.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_001017853.1	COG1539 dihydroneopterin aldolase [Coenzyme metabolism]
YP_001017860.1	COG2252 Permeases [general function prediction only]
YP_001017863.1	COG339 Zn-dependent oligopeptidases [Amino acid transport and metabolism]
YP_001017864.1	shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunit D, with NdhB and NdhF are core membrane components
YP_001017865.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_001017866.1	COG837 glucokinase [carbohydrate transport and metabolism]
YP_001017869.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_001017871.1	COG4678 Muramidase (phage lambda lysozyme) [carbohydrate transport and metabolism]
YP_001017872.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001017876.1	COG803 ABC-type metal ion transporter, periplasmic component/surface adhesin [inorganic ion transport and metabolism]
YP_001017877.1	COG1121 ABC-type Mn/Zn transporters, ATPase component [inorganic ion transport and metabolism]
YP_001017878.1	COG1108 ABC-type Mn2+/Zn2+ transporters, permease components [inorganic ion transport and metabolism]
YP_001017879.1	COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism]
YP_001017880.1	COG644 dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001017881.1	COG3424 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001017886.1	COG681 Signal peptidase I [Intracellular trafficking and secretion]
YP_001017887.1	Menaquinone biosynthesis protein; COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]
YP_001017888.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_001017890.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_001017893.1	COG770 UDP-N-acetylmuramyl pentapeptide synthase [cell envelope biogenesis, outer membrane]
YP_001017894.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_001017895.1	COG4121 Uncharacterized conserved protein [Function unknown]
YP_001017896.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_001017897.1	COG43 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]
YP_001017898.1	catalyzes the formation of (2R)-3-sulfolactate from (2R)-2-phospho-3-sulfolactate
YP_001017899.1	COG388 Predicted amidohydrolase [general function prediction only]
YP_001017900.1	COG860 N-acetylmuramoyl-L-alanine amidase [cell envelope biogenesis, outer membrane]
YP_001017901.1	COG796 glutamate racemase [cell envelope biogenesis, outer membrane]
YP_001017902.1	COG142 geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
YP_001017903.1	COG637 Predicted phosphatase/phosphohexomutase [general function prediction only]
YP_001017906.1	COG365 acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [lipid metabolism]
YP_001017908.1	COG1225 peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001017909.1	COG847 DNA polymerase III subunit epsilon and related 3'-5' exonucleases [DNA replication, recombination, and repair]
YP_001017910.1	COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold [general function prediction only]
YP_001017911.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001017920.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001017921.1	COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [transcription / Signal transduction mechanisms]
YP_001017922.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_001017923.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001017927.1	COG2135 Uncharacterized conserved protein [Function unknown]
YP_001017930.1	COG117 Pyrimidine deaminase [Coenzyme metabolism]
YP_001017932.1	COG4354 Predicted bile acid beta-glucosidase [carbohydrate transport and metabolism]
YP_001017938.1	COG2242 precorrin-6B methylase 2 [Coenzyme metabolism]
YP_001017939.1	COG1430 Uncharacterized conserved protein [Function unknown]
YP_001017940.1	catalyzes the phosphorylation of NAD to NADP
YP_001017941.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_001017942.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_001017944.1	COG196 FAD synthase [Coenzyme metabolism]
YP_001017946.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_001017947.1	COG2104 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]
YP_001017948.1	COG4371 Predicted membrane protein [Function unknown]
YP_001017951.1	COG1691 NCAIR mutase (PurE)-related proteins [general function prediction only]
YP_001017953.1	COG336 tRNA-(guanine-N1)-methyltransferase [translation, ribosomal structure and biogenesis]
YP_001017954.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_001017956.1	COG385 Predicted Na+-dependent transporter [general function prediction only]
YP_001017958.1	COG3659 carbohydrate-selective porin [cell envelope biogenesis, outer membrane]
YP_001017959.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001017960.1	COG670 integral membrane protein, interacts with FtsH [general function prediction only]
YP_001017961.1	COG1702 phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]
YP_001017962.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_001017963.1	COG541 Signal recognition particle GTPase [Intracellular trafficking and secretion]
YP_001017966.1	COG1071 pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, subunit alpha [Energy production and conversion]
YP_001017967.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001017968.1	COG63 Predicted sugar kinase [carbohydrate transport and metabolism]
YP_001017969.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_001017970.1	COG815 Apolipoprotein N-acyltransferase [cell envelope biogenesis, outer membrane]
YP_001017975.1	COG4424 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001017979.1	COG545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]
YP_001017984.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_001017985.1	E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001017986.1	COG566 rRNA methylases [translation, ribosomal structure and biogenesis]
YP_001017990.1	COG766 UDP-N-acetylglucosamine enolpyruvyl transferase [cell envelope biogenesis, outer membrane]
YP_001017991.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_001017992.1	COG285 Folylpolyglutamate synthase [Coenzyme metabolism]
YP_001017993.1	COG1357 Uncharacterized low-complexity proteins [Function unknown]
YP_001017994.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001017996.1	COG402 cytosine deaminase and related metal-dependent hydrolases [nucleotide transport and metabolism / general function prediction only]
YP_001017999.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_001018000.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_001018002.1	COG1589 cell division septal protein [cell envelope biogenesis, outer membrane]
YP_001018004.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_001018005.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_001018006.1	COG635 coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]
YP_001018008.1	COG4956 integral membrane protein (PIN domain superfamily) [general function prediction only]
YP_001018009.1	ClpR variant present in an operon with ClpP3 in Synechococcus PCC7942; ClpR is missing the catalytic triad Ser-His-Asp characteristic of serine-type proteases; the exact function of ClpR and ClpP3 is unknown however they appear to be necessary for cell viability; hydrolyzes proteins to small peptides; with the ATPases ClpA or ClpX, ClpP degrades specific substrates
YP_001018010.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001018011.1	COG5361 Uncharacterized conserved protein [Function unknown]
YP_001018012.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_001018013.1	COG1270 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]
YP_001018015.1	COG2148 Sugar transferases involved in lipopolysaccharide synthesis [cell envelope biogenesis, outer membrane]
YP_001018016.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018018.1	COG146 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018022.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_001018023.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamide and glutamine to imidazole-glycerolphosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_001018025.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001018027.1	COG3311 Predicted transcriptional regulator [transcription]
YP_001018030.1	COG3311 Predicted transcriptional regulator [transcription]
YP_001018033.1	COG1961 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]
YP_001018042.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018046.1	COG658 Predicted membrane metal-binding protein [general function prediction only]
YP_001018048.1	COG1840 ABC-type Fe3+ transporter, periplasmic component [inorganic ion transport and metabolism]
YP_001018052.1	COG3128 Uncharacterized iron-regulated protein [Function unknown]
YP_001018055.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001018056.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001018058.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001018063.1	COG2226 methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001018065.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_001018067.1	COG382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]
YP_001018068.1	COG744 membrane carboxypeptidase (penicillin-binding protein) [cell envelope biogenesis, outer membrane]
YP_001018069.1	COG144 tRNA and rRNA cytosine-C5-methylases [translation, ribosomal structure and biogenesis]
YP_001018070.1	COG3695 Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]
YP_001018071.1	COG566 rRNA methylases [translation, ribosomal structure and biogenesis]
YP_001018073.1	COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permeases [Amino acid transport and metabolism / inorganic ion transport and metabolism]
YP_001018075.1	COG3220 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018077.1	COG179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018079.1	COG5031 Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]
YP_001018080.1	COG688 phosphatidylserine decarboxylase [lipid metabolism]
YP_001018082.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001018088.1	COG4968 Tfp pilus assembly protein PilE [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018089.1	COG2165 type II secretory pathway, pseudopilin PulG [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018094.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_001018097.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_001018098.1	COG694 thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]
YP_001018102.1	COG1704 Uncharacterized conserved protein [Function unknown]
YP_001018107.1	COG4403 Lantibiotic modifying enzyme [Defense mechanisms]
YP_001018108.1	COG3239 Fatty acid desaturase [lipid metabolism]
YP_001018110.1	COG520 Selenocysteine lyase [Amino acid transport and metabolism]
YP_001018112.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [general function prediction only]
YP_001018113.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_001018115.1	COG759 Uncharacterized conserved protein [Function unknown]
YP_001018116.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_001018118.1	COG626 cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]
YP_001018119.1	COG626 cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]
YP_001018120.1	COG31 Cysteine synthase [Amino acid transport and metabolism]
YP_001018121.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_001018124.1	COG531 Amino acid transporters [Amino acid transport and metabolism]
YP_001018129.1	COG508 pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]
YP_001018134.1	COG683 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]
YP_001018139.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming) [lipid metabolism]
YP_001018140.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system protein H
YP_001018141.1	COG1544 ribosome-associated protein Y (PSrp-1) [translation, ribosomal structure and biogenesis]
YP_001018142.1	COG274 deoxyribose-phosphate aldolase [nucleotide transport and metabolism]
YP_001018143.1	COG1381 recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]
YP_001018144.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001018145.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018146.1	COG345 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
YP_001018147.1	COG1799 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018148.1	COG325 Predicted enzyme with a TIM-barrel fold [general function prediction only]
YP_001018150.1	COG619 ABC-type cobalt transporter, permease component CbiQ and related transporters [inorganic ion transport and metabolism]
YP_001018151.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_001018157.1	COG42 tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]
YP_001018159.1	COG2243 precorrin-2 methylase [Coenzyme metabolism]
YP_001018160.1	COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]
YP_001018161.1	COG4445 hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA [nucleotide transport and metabolism / translation, ribosomal structure and biogenesis]
YP_001018162.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_001018168.1	COG1115 Na+/alanine symporter [Amino acid transport and metabolism]
YP_001018169.1	COG366 glycosidases [carbohydrate transport and metabolism]
YP_001018171.1	COG1012 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]
YP_001018173.1	COG514 Superfamily II DNA helicase [DNA replication, recombination, and repair]
YP_001018175.1	Stabilizes the interaction between PsaC and the photosystem I core
YP_001018176.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_001018177.1	COG235 ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [carbohydrate transport and metabolism]
YP_001018178.1	COG4229 Predicted enolase-phosphatase [Energy production and conversion]
YP_001018184.1	PetD, with cytochrome b6, cytochrome F, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001018185.1	electron transporter
YP_001018186.1	COG793 Periplasmic protease [cell envelope biogenesis, outer membrane]
YP_001018187.1	COG1078 HD superfamily phosphohydrolases [general function prediction only]
YP_001018188.1	COG850 septum formation inhibitor [cell division and chromosome partitioning]
YP_001018189.1	COG2894 septum formation inhibitor-activating ATPase [cell division and chromosome partitioning]
YP_001018190.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_001018193.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018204.1	COG9  translation factor (SUA5) [translation, ribosomal structure and biogenesis]
YP_001018205.1	COG2890 methylase of polypeptide chain release factors [translation, ribosomal structure and biogenesis]
YP_001018206.1	COG758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]
YP_001018207.1	COG824 Predicted thioesterase [general function prediction only]
YP_001018211.1	COG633 Ferredoxin [Energy production and conversion]
YP_001018215.1	COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [transcription]
YP_001018216.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_001018217.1	COG637 Predicted phosphatase/phosphohexomutase [general function prediction only]
YP_001018218.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_001018219.1	COG1070 Sugar (pentulose and hexulose) kinases [carbohydrate transport and metabolism]
YP_001018221.1	COG1040 Predicted amidophosphoribosyltransferases [general function prediction only]
YP_001018235.1	COG1413 FOG: HEAT repeat [Energy production and conversion]
YP_001018241.1	COG5398 Heme oxygenase [inorganic ion transport and metabolism]
YP_001018243.1	catalyzes the reduction of biliverdin IX-alpha to 15,16-dihydrobiliverdin
YP_001018244.1	catalyzes the reduction of 15,16-dihydrobiliverdin to (3Z)-phycoerythrobilin
YP_001018246.1	COG394 protein-tyrosine-phosphatase [Signal transduction mechanisms]
YP_001018247.1	catalyzes the formation of pantothenate from pantoate and beta-alanine and the formation of cytidine diphosphate from cytidine monophosphate
YP_001018248.1	COG797 Lipoproteins [cell envelope biogenesis, outer membrane]
YP_001018249.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_001018261.1	COG4370 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018267.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_001018268.1	COG489 ATPases involved in chromosome partitioning [cell division and chromosome partitioning]
YP_001018269.1	COG772 Bacterial cell division membrane protein [cell division and chromosome partitioning]
YP_001018270.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001018272.1	COG147 anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001018273.1	COG2170 Uncharacterized conserved protein [Function unknown]
YP_001018274.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_001018278.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_001018279.1	Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_001018287.1	COG1606 ATP-utilizing enzymes of the PP-loop superfamily [general function prediction only]
YP_001018288.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001018289.1	COG476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]
YP_001018292.1	COG3001 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018293.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018294.1	catalyzes the formation of tyrosine from arogenate
YP_001018297.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_001018298.1	COG546 Predicted phosphatases [general function prediction only]
YP_001018299.1	COG3854 ncharacterized protein conserved in bacteria [Function unknown]
YP_001018302.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_001018303.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_001018304.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_001018305.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_001018306.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_001018307.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_001018308.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_001018309.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_001018310.1	one of the stabilizing components for the large ribosomal subunit
YP_001018311.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_001018312.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_001018313.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_001018315.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_001018316.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_001018317.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_001018318.1	binds 5S rRNA along with protein L5 and L25
YP_001018319.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_001018320.1	late assembly protein
YP_001018321.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_001018322.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_001018323.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_001018324.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_001018325.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_001018326.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_001018327.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_001018328.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_001018329.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_001018330.1	forms a direct contact with the tRNA during translation
YP_001018331.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001018332.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_001018333.1	COG1403 Restriction endonuclease [Defense mechanisms]
YP_001018334.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_001018337.1	COG1091 dTDP-4-dehydrorhamnose reductase [cell envelope biogenesis, outer membrane]
YP_001018339.1	COG3588 fructose-1,6-bisphosphate aldolase [carbohydrate transport and metabolism]
YP_001018342.1	COG791 cell wall-associated hydrolases (invasion-associated proteins) [cell envelope biogenesis, outer membrane]
YP_001018343.1	COG463 glycosyltransferases involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018347.1	with PsaA binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I
YP_001018348.1	with PsaB binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I
YP_001018350.1	COG1010 precorrin-3B methylase [Coenzyme metabolism]
YP_001018351.1	COG644 dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001018354.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001018355.1	COG2350 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018356.1	COG69 glutamate synthase domain 2 [Amino acid transport and metabolism]
YP_001018359.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_001018360.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_001018361.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_001018362.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001018364.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_001018365.1	COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease [general function prediction only]
YP_001018366.1	COG500 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001018367.1	COG77 prephenate dehydratase [Amino acid transport and metabolism]
YP_001018369.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_001018370.1	COG1530 ribonucleases G and E [translation, ribosomal structure and biogenesis]
YP_001018372.1	catalyzes the interconversion of tetrahydrodipicolinate and L,L-diaminopimelate in lysine biosynthesis
YP_001018373.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_001018375.1	COG1032 Fe-S oxidoreductase [Energy production and conversion]
YP_001018377.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_001018381.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001018382.1	COG2046 ATP sulfurylase (sulfate adenylyltransferase) [inorganic ion transport and metabolism]
YP_001018385.1	COG452 phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]
YP_001018390.1	COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
YP_001018391.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_001018392.1	COG2094 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]
YP_001018396.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001018403.1	COG4974 Site-specific recombinase XerD [DNA replication, recombination, and repair]
YP_001018405.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018406.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018408.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018414.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018415.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001018416.1	COG2094 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]
YP_001018417.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001018426.1	COG1402 Uncharacterized protein,  amidase [general function prediction only]
YP_001018427.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_001018428.1	COG3239 Fatty acid desaturase [lipid metabolism]
YP_001018429.1	COG60 isoleucyl-tRNA synthetase [translation, ribosomal structure and biogenesis]
YP_001018434.1	COG4398 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018435.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_001018436.1	COG3307 lipid A core - O-antigen ligase and related enzymes [cell envelope biogenesis, outer membrane]
YP_001018437.1	COG2971 Predicted N-acetylglucosamine kinase [carbohydrate transport and metabolism]
YP_001018438.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_001018444.1	COG526 thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]
YP_001018449.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_001018450.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001018451.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_001018452.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001018453.1	COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]
YP_001018456.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_001018457.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_001018458.1	may be involved in regulating PSII assembly and/or stability
YP_001018461.1	4.8-kDa protein; may be involved in assembling and stabilizing of PSII dimers
YP_001018464.1	COG66 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]
YP_001018465.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_001018466.1	COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [general function prediction only]
YP_001018467.1	COG472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [cell envelope biogenesis, outer membrane]
YP_001018468.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_001018473.1	COG728 Uncharacterized membrane protein,  virulence factor [general function prediction only]
YP_001018474.1	Regulatory factor involved in maltose metabolism
YP_001018476.1	COG4 Ammonia permease [inorganic ion transport and metabolism]
YP_001018478.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_001018480.1	COG2259 Predicted membrane protein [Function unknown]
YP_001018481.1	involved in de novo purine biosynthesis
YP_001018482.1	COG400 Predicted esterase [general function prediction only]
YP_001018484.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001018485.1	COG368 Cobalamin-5-phosphate synthase [Coenzyme metabolism]
YP_001018486.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_001018487.1	may be involved in binding plastoquinone and maintaining PSII dimers
YP_001018488.1	COG1922 Teichoic acid biosynthesis proteins [cell envelope biogenesis, outer membrane]
YP_001018489.1	COG673 Predicted dehydrogenases and related proteins [general function prediction only]
YP_001018490.1	COG1253 Hemolysins and related proteins containing CBS domains [general function prediction only]
YP_001018492.1	COG461 Orotate phosphoribosyltransferase [nucleotide transport and metabolism]
YP_001018493.1	COG354 Predicted aminomethyltransferase related to GcvT [general function prediction only]
YP_001018494.1	COG2251 Predicted nuclease (RecB family) [general function prediction only]
YP_001018495.1	COG1109 phosphomannomutase [carbohydrate transport and metabolism]
YP_001018496.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_001018497.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001018498.1	COG2968 Uncharacterized conserved protein [Function unknown]
YP_001018507.1	COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018508.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_001018509.1	NADH-dependent; catalyzes a key regulatory step in fatty acid biosynthesis
YP_001018512.1	COG399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018513.1	COG5305 Predicted membrane protein [Function unknown]
YP_001018515.1	COG801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]
YP_001018516.1	COG1239 Mg-chelatase subunit ChlI [Coenzyme metabolism]
YP_001018517.1	COG1463 ABC-type transporter involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018518.1	COG1127 ABC-type transporter involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018519.1	COG391 Uncharacterized conserved protein [Function unknown]
YP_001018520.1	catalyzes the transfer of electrons from NADH to quinones
YP_001018521.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_001018522.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001018523.1	COG1773 Rubredoxin [Energy production and conversion]
YP_001018524.1	similar to Arabidopsis thaliana photosystem II assembly protein
YP_001018525.1	photosystem II reaction center subunit VI; associated with the reaction center of photosystem II
YP_001018526.1	photosystem II reaction center subunit VI; associated with the reaction center of photosystem II
YP_001018527.1	may have a role in PSII core assembly, maintaining PSII dimers and donor side electron transfer
YP_001018528.1	may be involved in assembling and maintaining PSII complexes in the thylakoid membrane
YP_001018529.1	COG5 Purine nucleoside phosphorylase [nucleotide transport and metabolism]
YP_001018530.1	isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway
YP_001018533.1	COG3347 Uncharacterized conserved protein [Function unknown]
YP_001018534.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001018535.1	COG1004 Predicted UDP-glucose 6-dehydrogenase [cell envelope biogenesis, outer membrane]
YP_001018536.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_001018540.1	COG1087 UDP-glucose 4-epimerase [cell envelope biogenesis, outer membrane]
YP_001018541.1	COG2148 Sugar transferases involved in lipopolysaccharide synthesis [cell envelope biogenesis, outer membrane]
YP_001018543.1	COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
YP_001018545.1	COG617 tRNA nucleotidyltransferase/poly(A) polymerase [translation, ribosomal structure and biogenesis]
YP_001018546.1	COG794 Predicted sugar phosphate isomerase involved in capsule formation [cell envelope biogenesis, outer membrane]
YP_001018547.1	COG1778 Low specificity phosphatase (HAD superfamily) [general function prediction only]
YP_001018549.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_001018552.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_001018555.1	COG210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]
YP_001018559.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018560.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018561.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018562.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001018563.1	COG1132 ABC-type multidrug transporter, ATPase and permeases [Defense mechanisms]
YP_001018569.1	COG2246 Predicted membrane protein [Function unknown]
YP_001018570.1	COG463 glycosyltransferases involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018572.1	Converts isocitrate to alpha ketoglutarate
YP_001018574.1	COG247 Fe-S oxidoreductase [Energy production and conversion]
YP_001018576.1	COG3395 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018577.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001018585.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [cell envelope biogenesis, outer membrane]
YP_001018587.1	COG676 Uncharacterized enzymes related to aldose 1-epimerase [carbohydrate transport and metabolism]
YP_001018588.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [general function prediction only]
YP_001018589.1	COG475 Kef-type K+ transporters, membrane components [inorganic ion transport and metabolism]
YP_001018591.1	COG58 glucan phosphorylase [carbohydrate transport and metabolism]
YP_001018595.1	COG571 dsRNA-specific ribonuclease [transcription]
YP_001018597.1	Essential for efficient processing of 16S rRNA
YP_001018598.1	COG836 mannose-1-phosphate guanylyltransferase [cell envelope biogenesis, outer membrane]
YP_001018599.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_001018600.1	part of the core of the reaction center of photosystem I
YP_001018601.1	carries the fatty acid chain in fatty acid biosynthesis
YP_001018602.1	COG304 3-oxoacyl-(acyl-carrier-protein) synthase [lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018603.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_001018604.1	COG451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane / carbohydrate transport and metabolism]
YP_001018605.1	COG463 glycosyltransferases involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018607.1	COG625 glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001018610.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_001018611.1	COG1472 beta-glucosidase-related glycosidases [carbohydrate transport and metabolism]
YP_001018612.1	COG463 glycosyltransferases involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018613.1	COG1587 uroporphyrinogen-III synthase [Coenzyme metabolism]
YP_001018615.1	COG5637 Predicted integral membrane protein [Function unknown]
YP_001018616.1	COG3349 Uncharacterized conserved protein [Function unknown]
YP_001018617.1	COG316 Uncharacterized conserved protein [Function unknown]
YP_001018620.1	COG4370 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018621.1	COG1090 Predicted nucleoside-diphosphate sugar epimerase [general function prediction only]
YP_001018622.1	COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [inorganic ion transport and metabolism]
YP_001018624.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [cell envelope biogenesis, outer membrane]
YP_001018625.1	COG2214 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001018626.1	COG31 Cysteine synthase [Amino acid transport and metabolism]
YP_001018631.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [cell envelope biogenesis, outer membrane]
YP_001018634.1	COG3463 Predicted membrane protein [Function unknown]
YP_001018636.1	COG3463 Predicted membrane protein [Function unknown]
YP_001018641.1	COG1122 ABC-type cobalt transporter, ATPase component [inorganic ion transport and metabolism]
YP_001018642.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001018643.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the subunit beta on the DNA
YP_001018644.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_001018645.1	COG2217 Cation transport ATPase [inorganic ion transport and metabolism]
YP_001018647.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_001018648.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001018649.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_001018650.2	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_001018651.1	COG331 (acyl-carrier-protein) S-malonyltransferase [lipid metabolism]
YP_001018652.1	COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [lipid metabolism]
YP_001018654.1	Inactive homolog of metal-dependent proteases
YP_001018656.1	COG617 tRNA nucleotidyltransferase/poly(A) polymerase [translation, ribosomal structure and biogenesis]
YP_001018659.1	COG1562 Phytoene/squalene synthetase [lipid metabolism]
YP_001018660.1	COG3349 Uncharacterized conserved protein [Function unknown]
YP_001018663.1	COG583 transcriptional regulator [transcription]
YP_001018664.1	COG4094 Predicted membrane protein [Function unknown]
YP_001018665.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_001018666.1	Shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain
YP_001018667.1	COG1354 Uncharacterized conserved protein [Function unknown]
YP_001018668.1	COG1208 nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/subunit epsilons (eIF-2Bgamma/eIF-2Bepsilon) [cell envelope biogenesis, outer membrane / translation, ribosomal structure an
YP_001018677.1	COG685 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]
YP_001018678.1	COG2771 DNA-binding HTH domain-containing proteins [transcription]
YP_001018680.1	COG2954 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018681.1	catalyzes the phosphorylation of NAD to NADP
YP_001018682.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001018683.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001018684.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001018686.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001018687.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_001018688.1	COG2062 phosphohistidine phosphatase SixA [Signal transduction mechanisms]
YP_001018691.1	COG1420 transcriptional regulator of heat shock gene [transcription]
YP_001018692.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001018698.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001018700.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_001018702.1	COG23 translation initiation factor 1 (eIF-1/SUI1) and related proteins [translation, ribosomal structure and biogenesis]
YP_001018704.1	COG529 adenylylsulfate kinase and related kinases [inorganic ion transport and metabolism]
YP_001018706.1	COG628 Predicted permease [general function prediction only]
YP_001018708.1	COG41 phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [nucleotide transport and metabolism]
YP_001018709.1	COG1820 N-acetylglucosamine-6-phosphate deacetylase [carbohydrate transport and metabolism]
YP_001018710.1	catalyzes the formation of Mg-protoporphyrin IX methyl ester and S-adenosyl-L-homocysteine from Mg-protoporphyrin IX and S-adenosyl-L-methionine
YP_001018712.1	COG564 Pseudouridylate synthases, 23S RNA-specific [translation, ribosomal structure and biogenesis]
YP_001018713.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / transcription]
YP_001018715.1	COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]
YP_001018717.1	COG2839 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018718.1	COG275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [cell envelope biogenesis, outer membrane]
YP_001018719.1	shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradien
YP_001018725.1	COG824 Predicted thioesterase [general function prediction only]
YP_001018727.1	COG318 acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018728.1	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [cell envelope biogenesis, outer membrane / general function prediction only]
YP_001018729.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate
YP_001018730.1	COG1169 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018731.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_001018732.1	COG695 glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]
YP_001018733.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_001018735.1	COG319 Predicted metal-dependent hydrolase [general function prediction only]
YP_001018736.1	COG818 diacylglycerol kinase [cell envelope biogenesis, outer membrane]
YP_001018737.1	COG512 anthranilate/para-aminobenzoate synthases component II [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001018739.1	COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold [general function prediction only]
YP_001018741.1	COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]
YP_001018742.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_001018743.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001018748.1	COG157 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]
YP_001018749.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_001018750.1	COG3216 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018759.1	COG668 Small-conductance mechanosensitive channel [cell envelope biogenesis, outer membrane]
YP_001018760.1	COG1773 Rubredoxin [Energy production and conversion]
YP_001018766.1	COG661 Predicted unusual protein kinase [general function prediction only]
YP_001018767.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_001018768.1	COG346 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]
YP_001018769.1	COG542 ATPases with chaperone activity, ATP-binding subunit [Posttranslational modification, protein turnover, chaperones]
YP_001018770.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_001018771.1	Modulates Rho-dependent transcription termination
YP_001018772.1	binds directly to 23S ribosomal RNA
YP_001018773.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_001018774.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_001018775.1	COG222 ribosomal protein L7/L12 [translation, ribosomal structure and biogenesis]
YP_001018778.1	COG328 ribonuclease HI [DNA replication, recombination, and repair]
YP_001018779.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_001018783.1	COG1450 type II secretory pathway, component PulD [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018785.1	COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]
YP_001018786.1	COG707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [cell envelope biogenesis, outer membrane]
YP_001018789.1	COG3502 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001018790.1	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [lipid metabolism]
YP_001018792.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_001018793.1	COG589 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]
YP_001018794.1	essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc)
YP_001018795.1	COG564 Pseudouridylate synthases, 23S RNA-specific [translation, ribosomal structure and biogenesis]
YP_001018796.1	COG3119 Arylsulfatase A and related enzymes [inorganic ion transport and metabolism]
YP_001018800.1	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase [general function prediction only]
YP_001018801.1	COG317 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / transcription]
YP_001018803.1	COG397 Uncharacterized conserved protein [Function unknown]
YP_001018818.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_001018819.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_001018822.1	COG463 glycosyltransferases involved in cell wall biogenesis [cell envelope biogenesis, outer membrane]
YP_001018823.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001018824.1	COG665 glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
YP_001018825.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_001018826.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_001018827.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001018828.1	COG4252 Predicted transmembrane sensor domain [Signal transduction mechanisms]
YP_001018832.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001018833.1	COG553 Superfamily II DNA/RNA helicases, SNF2 family [transcription / DNA replication, recombination, and repair]
YP_001018834.1	COG4279 Uncharacterized conserved protein [Function unknown]
YP_001018838.1	COG4663 TRAP-type mannitol/chloroaromatic compound transporter, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018839.1	COG4665 TRAP-type mannitol/chloroaromatic compound transporter, small permease [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018840.1	COG4664 TRAP-type mannitol/chloroaromatic compound transporter, large permease [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001018841.1	COG426 Uncharacterized flavoproteins [Energy production and conversion]
YP_001018843.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018845.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018854.1	COG1131 ABC-type multidrug transporter, ATPase component [Defense mechanisms]
YP_001018859.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018861.1	COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain [general function prediction only]
YP_001018862.1	COG515 serine/threonine protein kinase [general function prediction only / Signal transduction mechanisms / transcription / DNA replication, recombination, and repair]
YP_001018863.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018864.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018865.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001018866.1	COG3063 Tfp pilus assembly protein PilF [cell motility and secretion / Intracellular trafficking and secretion]
YP_001018867.1	COG457 FOG: TPR repeat [general function prediction only]
YP_001018868.1	COG1961 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]
YP_001018878.1	COG426 Uncharacterized flavoproteins [Energy production and conversion]
YP_001018879.1	COG1592 rubrerythrin [Energy production and conversion]
YP_001018881.1	COG431 Predicted flavoprotein [general function prediction only]
YP_001018885.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_001018886.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_001018887.1	COG4100 cystathionine beta-lyase family protein involved in aluminum resistance [inorganic ion transport and metabolism]
YP_001018888.1	COG1398 Fatty-acid desaturase [lipid metabolism]
YP_001018890.1	COG1398 Fatty-acid desaturase [lipid metabolism]
YP_001018891.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_001018892.1	COG305 Replicative DNA helicase [DNA replication, recombination, and repair]
YP_001018893.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_001018895.1	COG3161 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]
YP_001018897.1	similar to Viral (Superfamily 1) RNA helicase
YP_001018901.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_001018903.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001018905.1	COG3694 ABC-type uncharacterized transporter, permease [general function prediction only]
YP_001018906.1	COG4587 ABC-type uncharacterized transporter, permease [general function prediction only]
YP_001018907.1	COG4586 ABC-type uncharacterized transporter, ATPase component [general function prediction only]
YP_001018909.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_001018914.1	COG633 Ferredoxin [Energy production and conversion]
YP_001018915.1	oxidative; catalyzes the formation of divinylprotochlorophyllide from magnesium-protoporphyrin IX 13-monomethyl ester in isocyclic ring formation in chlorophyll biosynthesis
YP_001018916.1	COG640 Predicted transcriptional regulators [transcription]
YP_001018919.1	COG259 pyridoxamine-phosphate oxidase [Coenzyme metabolism]
YP_001018920.1	COG1221 transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [transcription / Signal transduction mechanisms]
YP_001018921.1	COG1108 ABC-type Mn2+/Zn2+ transporters, permease components [inorganic ion transport and metabolism]
YP_001018922.1	COG1121 ABC-type Mn/Zn transporters, ATPase component [inorganic ion transport and metabolism]
YP_001018923.1	COG803 ABC-type metal ion transporter, periplasmic component/surface adhesin [inorganic ion transport and metabolism]
YP_001018927.1	COG701 Predicted permeases [general function prediction only]
YP_001018929.1	COG735 Fe2+/Zn2+ uptake regulation proteins [inorganic ion transport and metabolism]
YP_001018932.1	COG2389 Uncharacterized metal-binding protein [general function prediction only]
YP_001018933.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_001018937.1	COG1213 Predicted sugar nucleotidyltransferases [cell envelope biogenesis, outer membrane]
YP_001018938.1	COG2071 Predicted glutamine amidotransferases [general function prediction only]
YP_001018940.1	COG500 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / general function prediction only]
YP_001018945.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_001018946.1	COG10 arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]
YP_001018948.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_001018950.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_001018951.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001018952.1	COG783 DNA-binding ferritin-like protein (oxidative damage protectant) [inorganic ion transport and metabolism]
YP_001018953.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_001018954.1	COG602 organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]
YP_001018956.1	COG1943 transposase and inactivated derivatives [DNA replication, recombination, and repair]
YP_001018962.1	COG603 Predicted PP-loop superfamily ATPase [general function prediction only]
YP_001018963.1	COG147 anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001018964.1	COG115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001018965.1	COG410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]
YP_001018966.1	COG4674 Uncharacterized ABC-type transporter, ATPase component [general function prediction only]
YP_001018967.1	COG4177 ABC-type branched-chain amino acid transport system, permease [Amino acid transport and metabolism]
YP_001018968.1	COG559 Branched-chain amino acid ABC-type transport system, permeases [Amino acid transport and metabolism]
YP_001018969.1	COG683 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]
YP_001018970.1	COG378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / transcription]
YP_001018971.1	COG830 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]
YP_001018972.1	COG2371 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]
YP_001018973.1	COG829 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]
YP_001018974.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_001018975.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active
YP_001018976.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_001018977.1	COG7 uroporphyrinogen-III methylase [Coenzyme metabolism]
YP_001018978.1	mutS
YP_001018981.1	ferredoxin-dependent assimilatory nitrite reductase
YP_001018983.1	COG2116 formate/nitrite family of transporters [inorganic ion transport and metabolism]
YP_001018986.1	COG547 anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]
YP_001018988.1	COG2814 Arabinose efflux permease [carbohydrate transport and metabolism]
YP_001018989.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_001018990.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [transcription]
YP_001018991.1	COG170 Dolichol kinase [lipid metabolism]
YP_001018992.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_001018993.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_001018994.1	COG38 chloride channel protein EriC [inorganic ion transport and metabolism]
YP_001018995.1	COG1032 Fe-S oxidoreductase [Energy production and conversion]
YP_001018997.1	COG788 Formyltetrahydrofolate hydrolase [nucleotide transport and metabolism]
YP_001018998.1	COG665 glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
YP_001018999.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001019000.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_001019002.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_001019004.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_001019007.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_001019011.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_001019012.1	COG438 glycosyltransferase [cell envelope biogenesis, outer membrane]
YP_001019013.1	COG4188 Predicted dienelactone hydrolase [general function prediction only]
YP_001019014.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_001019015.1	COG497 ATPase involved in DNA repair [DNA replication, recombination, and repair]
YP_001019016.1	COG661 Predicted unusual protein kinase [general function prediction only]
YP_001019018.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine